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In recent years there has been international interest in media portrayal of suicide and mental illness and the impact that reporting may have on community understanding, attitudes and behaviour. Many countries have developed guidelines and resources for media reporting to encourage responsible and sensitive coverage. H... |
In order to know a scientific discipline or to establish a scientific major, it is necessary to study and identify the epistemological geometry of that discipline or major. This includes categories such as definition, purpose, subject, duties and responsibilities, methods and issues. It seems necessary to establish the... |
This paper focuses on two nonclassical effects in the behavior of thin-walled composite heams: elastic hendingshear coupling and restrained torsional warping. These nonclassical effects are clarified and analyzed in some simple examples involving cantilevered beams. First, elastic bending-transverse shear coupling is s... |
This study investigated the effects of body posture on state anxiety and psychological stress. Twenty normal adults performed a demanding mental arithmetic task in both standing and supine conditions, with subjective measures of anxiety and stress obtained before, immediately, and 10 min after the task. Participants we... |
A smart mother makes often a better diagnosis than a poor doctor.
August Bier German, professor of surgery 1861–1949. |
Statistical diagnosis is a mystery to many health practitioners.1 Information is often presented as test accuracy (sensitivity and specificity). However, at the bedside we need to know how a test result predicts the diagnosis or outcome of interest. Attempts to demystify approaches to diagnosis include the construction... |
The likelihood ratio (LR) summarises information about the diagnostic test by combining information about the sensitivity and specificity . It tells you how much a positive or negative result changes …Loop-Level Profiling and Analysis of DoD Applications Using TAU |
Performance of computationally intensive applications often depends critically on the floating point and memory performance of nested loop structures, this paper describes extensions to the Tuning Analysis and Utilities (TAU) parallel performance system that implement automated of parallel C/C++ and Fortran programs to... |
We read with interest the recent study by Yang et al , who reported the construction of three-dimensional bioprinted hepatorganoids (3DP-HOs) using HepaRG cells and bioinks.1 We congratulate the authors for this pioneering study that demonstrates the fabrication and in vivo application of functional 3DP-HOs in mice mod... |
First, the study showed that after 7 days of differentiation in vitro, HepaRG cells in 3DP-HOs expressed hepatic marker genes and exhibited albumin secretion (figure 2). However, it is to be noted that most of …Malaysian Corporate Spin-Offs: Wealth Redistribution Relations with Debt and Liquidity |
The reviewed corporate spin-offs studies mostly in US, delved into wealth impact in the stock market. Different researchers espouse wealth creation on the various market models. This study also examines the wealth impacts of spin-off events, but in Malaysia, an emerging market place which is rare and further analyses t... |
In recent years, AI research has become more and more computationally demanding. In natural language processing (NLP), this tendency is reflected in the emergence of large language models (LLMs) like GPT-3. These powerful neural network-based models can be used for a range of NLP tasks and their language generation cap... |
STUDY OBJECTIVES |
To interact with the robotic Phoenix Mars Lander (PML) spacecraft, mission personnel were required to work on a Mars day (24.65 h) for 78 days. This alien schedule presents a challenge to Earth-bound circadian physiology and a potential risk to workplace performance and safety. We evaluated the acceptability, feasibili... |
DESIGN |
Operational field study. |
SETTING |
PML Science Operations Center. |
PARTICIPANTS |
Scientific and technical personnel supporting PML mission. |
INTERVENTIONS |
Sleep and fatigue education was offered to all support personnel. A subset (n = 19) were offered a short-wavelength (blue) light panel to aid alertness and mitigate/reduce circadian desynchrony. They were assessed using a daily sleep/work diary, continuous wrist actigraphy, and regular performance tests. Subjects also ... |
MEASUREMENTS AND RESULTS |
Most participants (87%) exhibited a circadian period consistent with adaptation to a Mars day. When synchronized, main sleep duration was 5.98 ± 0.94 h, but fell to 4.91 ± 1.22 h when misaligned (P < 0.001). Self-reported levels of fatigue and sleepiness also significantly increased when work was scheduled at an inappr... |
CONCLUSIONS |
The ability of the participants to adapt successfully to the Mars day suggests that future missions should utilize a similar circadian rhythm and fatigue management program to reduce the risk of sleepiness-related errors that jeopardize personnel safety and health during critical missions.Structural Analysis of COVID-1... |
Here, we analyze the structural |
features of a ligand binding domain (LBD) in COVID-19 main protease (MP) |
followed by the interactions between the inhibitor N3 and MP-LBD residues |
through the molecular dynamics simulations. The time based changes in physical |
parameters that includes root mean square deviation (RMSD), root mean square |
fluctuation (RMSF), radius of gyration (RG), dihedral distributions, residue |
velocity, radial distribution function (RDF) and H-bonding signify the degrees |
of folding states in MP-N3 complex formed by the superimposed b-barrels and flexible a-helices. Sharp and flat RDF peaks observed for the atom pairs dictate the |
flexibility of MP-LBD residues during their interactions with N3. In spite of |
larger solvent accessibility of N3, it interacts strongly with the LBD residues |
resulting in H-bonding. Among the LBD residues, GLU166 is found to have the |
lowest residue velocity that offers the sharp RDF peaks for three H-bonding |
atom pairs nearly at 2 Å radial distance, whereas GLY143 has the highest value |
of residue velocity giving rise to a flat RDF peak for the MP-N3 atom pair. |
Furthermore, electrostatic and van der Waals interaction energies between N3 |
and MP-LBD residues are noted to have the negative values. All these parameters |
explain the binding nature of N3 like inhibitors to the substrate binding sites |
of COVID-19 main protease. These analysis are expected to be a possible route |
applicable in drug designing mechanism to restrict the viral replication and |
transcription of COVID-19.Type VII collagen is expressed but anchoring fibrils are defective in dystrophic epidermolysis bullosa inversa |
A patient with dystrophic epidermolysis bullosa inversa was studied using electron microscopy and indirect immunofluorescence using antibodies to matrix macromolecules of the dermo‐epidermal junction zone. There was splitting below the lamina densa with an apparently normal basement membrane, but a lack of intact ancho... |
Minimally invasive techniques have been accepted as safe and reliable in the work-up of patients with lymphoproliferative disorders. As the oncologic indications of laparoscopy expand, many authors have raised concerns regarding the occurrence of port site metastases after minimally invasive procedures for a multiform ... |
These findings identify amplified ERK1/2 signaling in KRAS-mutated colorectal cancer cells as a driver of tumor–stroma interactions that favor formation of metastases in the liver. Carcinoma development in colorectal cancer is driven by genetic alterations in numerous signaling pathways. Alterations in the RAS-ERK1/2 p... |
The lack of preparedness and the adoption of a reactive approach underlie many mistakes in handling the COVID-19 pandemic. We need a vision with a proactive approach to planetary health prevention, that is suited for addressing the neglected systemic determinants of health which generate disease, inequality and environ... |
Neurotransmission is the basis of brain functions, and controllable neurotransmission tuning constitutes an attractive approach for interventions in a wide range of neurologic disorders and for synapse-based therapeutic treatments. Graphene-family nanomaterials (GFNs) offer promising advantages for biomedical applicati... |
This paper proposes equity home bias as a proxy for financial integration in the ongoing empirical debate on the impact of financial integration on economic growth. In integrated markets, investors are expected to take full advantage of the potential for international diversification. The extent of equity home bias (i.... |
We developed hydrolytic microneedles as a transdermal drug delivery system to overcome the shortcomings of existing microneedle-systems: long-term stay of broken needles in the skin and high cost for safe disposal of used needles. The present microneedles spontaneously dissolve by hydrolysis in human skin as well as in... |
Spectrofluoremetric technique was employed to study the binding behavior of hydralazine with bovine serum albumin (BSA) at different temperatures. Binding study of bovine serum albumin with hydralazine has been studied by ultraviolet–visible spectroscopy, fluorescence spectroscopy and confirmed by three‐dimensional, sy... |
Considering the endogenous structure of the aggregate supply curve, Okun's law, and the monetary output effect, this paper calculates the Chinese quarterly output gap between 1995Q4 and 2017Q2 using an SVAR model based on the inflation rate, real output, the unemployment rate and M2. Then, we reveal the influence of th... |
AIM |
To investigate the association of clinical variables and polymorphisms (tag SNPs) in the interleukin 4 (IL4) gene, with the prognosis of avulsed and replanted teeth. |
METHODOLOGY |
Ninety-four patients who suffered avulsion and had their teeth replanted and endodontically treated were included. Periapical radiographs were obtained soon after tooth replantation and after 1 year. For genotypic IL4 gene analysis, the DNA from oral mucosa cells was collected, and polymorphisms were investigated by re... |
RESULTS |
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