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Activator protein-1 (AP-1) is a transcription factor that consists of either a Jun-Jun homodimer or a Jun-Fos heterodimer. Transactivation of AP-1 is required for tumor promoter-induced transformation in mouse epidermal JB6 cells and for progression in mouse and human keratinocytes. Until now, the question of whether A... |
Abstract : With all of the attention focused these days on defense procurement scandals and congressional involvement in military management, it may be useful to recall that events of this nature are nothing new for the United States. Indeed, the story of the first congressional investigation -- then and now perhaps th... |
In this paper, we describe the technique for optimization of demanding DSP applications on a dual core DSP-s. In addition to common techniques of optimization, we use the Advanced Multi-core Optimization Technique, resolving load balancing problem. The methodology of the proposed technique is based on the application p... |
Abstract Background: From an evolutionary standpoint, olfaction is one of the oldest senses, and one that affects all aspects of life. This review discusses the influence of olfaction and pheromones on life. Methods: A literature search was conducted using MEDLINE (1966–2012), Embase (1988–2012), The Cochrane Library (... |
The objective was to develop a three-dimensional coupled fluid-structure computational model of the aortic valve and root. The long-term goal is to develop a framework for quantitative noninvasive evaluation, and design of new therapeutic treatment options for aortic valve and root disease. A 3-D geometric model was de... |
For future low carbon mobility society, new-type small electric vehicles (EVs) are developed actively in recent period. To reduce the energy consumption in various actual driving conditions, considering overall running resistance from tire characteristics, mechanical losses and electrical losses is necessary. Also, to ... |
Our colleague and friend Uwe Schöning, who has helped to shape the area of Complexity Theory in many decisive ways is turning 60 this year. As a little birthday present we survey in this column some of the newer results related with the concept of lowness, an idea that Uwe translated from the area of Recursion Theory i... |
Biomedical databases grow by more than a thousand new publications every day. The large volume of biomedical literature that is being published at an unprecedented rate hinders the discovery of relevant knowledge from keywords of interest to gather new insights and form hypotheses. A text-mining tool, PubTator, helps t... |
Abstract With the increasing interest in polymeric nanoparticles for biomedical applications, there is a need for continuous flow methodologies that allow for the precise control of nanoparticle synthesis. Poly(lactide-co-glycolic) acid (PLGA) nanoparticles with diameters of 220–250 nm were synthesized using a lab-on-a... |
The structural and electronic properties of Cu3O3- and Cu3O4- were investigated using mass-selected anion photoelectron spectroscopy in combination with density functional theoretical calculations. The vertical detachment energies of Cu3O3- and Cu3O4- were measured to be 3.48 ± 0.08 and 3.54 ± 0.08 eV, respectively. Th... |
This paper proposes a voltage equalizer using flyback converter with active clamp. This novel voltage equalizer is able to reduce the power losses. An active clamp circuit is used as an auxiliary circuit to achieve zero voltage switching (ZVS). Simulation results with PSIM and experimental results are shown. The propos... |
Before I attempt to express a point of view about "What the Executive Expects of the Corporate Law Department," I think I should make clear the limitations from which I speak. In the first place, as was apparent from our chairman's remarks, I speak as a corporate executive who has worked both sides of the street, and w... |
BACKGROUND: Preimplantation genetic diagnosis or screening (PGD, PGS) involves embryo biopsy on Day 3. Opting for one- or two-cell biopsy is a balance between the lowest risk for misdiagnosis on the one hand and the highest chance for a pregnancy on the other hand. METHODS: A prospective controlled trial was designed a... |
Two cases of hypereosinophilic syndrome that illustrate different variants are reported. Recognition of the specific variant is important because the treatments differ. Patients with hypereosinophilic syndrome should be monitored for evidence of a myeloproliferative process because treatment with tyrosine kinase inhibi... |
AIMS AND OBJECTIVES |
To determine the level of post-traumatic stress symptoms and to identify demographics, disease history and clinical symptoms that were associated with post-traumatic stress symptoms among patients with gynaecological, breast or colorectal cancer in Taiwan. |
BACKGROUND |
Literature indicated that 7·3-35·2% of patients with cancer had experienced level of post-traumatic stress symptoms. However, the post-traumatic stress symptoms among patients with cancer in Taiwan was not documented. |
DESIGN |
A cross-sectional study. |
METHODS |
A total of 347 participants recruited from two general hospitals in southern Taiwan. They completed the Chinese version of Davidson Trauma Scale and a profile describing their demographics and clinical symptoms. Disease history was collected from medical records. |
RESULTS |
Approximately 21·6% of participants reported higher score on Chinese version of Davidson Trauma Scale (Mean ± SD = 22·85 ± 24·12). The top four scores on Chinese version of Davidson Trauma Scale were painful memories, insomnia, shortened lifespan and flashbacks. The risk factors of post-traumatic stress symptoms were s... |
CONCLUSION |
To prevent post-traumatic stress symptoms, patients with cancer should be routinely screened by psychiatrists for post-traumatic stress symptoms, for ongoing symptom control and suicidal intention. Patients with cancer who are at risk of suicidal behaviour should be enrolled in suicide prevention programmes. |
RELEVANCE TO CLINICAL PRACTICE |
Nurses need to assess post-traumatic stress symptoms of patients with cancer, particularly those who with high education, suffered from complications of chemotherapy, metastasis and cancer-specific symptoms and suicidal intention.Ethical and Practical Guidelines for Reporting Genetic Research Results to Study Participa... |
In January 2009, the National Heart, Lung, and Blood Institute convened a 28-member multidisciplinary Working Group to update the recommendations of a 2004 National Heart, Lung, and Blood Institute Working Group focused on Guidelines to the Return of Genetic Research Results. Changes in the genetic and societal landsca... |
Abstract This paper offers a simple strategic framework to help governments identify various policy mechanisms to minimize public sector corruption. The paper offers a formal model that blends the economics of crime with identity economics and money laundering. It presents a partial equilibrium framework that focuses o... |
As a country with many islands, Indonesia is also surrounded by an ocean that is two-thirds wider than the territory of its own country. So Indonesia must be able to manage and organize the sea regularly to be used for the welfare of the people. Marine spatial planning is not only done to organize what is above the sea... |
Objectives/Hypothesis In a previous publication, we introduced an endoscopic technique for the treatment of nasal obstruction caused by inferior turbinate hypertrophy. The technique, a modification of the procedure popularized by Mabry, involves resecting the inferior and lateral aspects of the inferior turbinate with ... |
The exposition and discovery of intelligence especially for connected devices and autonomous systems have become an important area of the research towards an all-intelligent world. In this article, it a semantic description of functions is proposed and used to provide intelligence services mainly for networked devices.... |
Using immunocytochemical and biochemical methods, we analyzed the localization of HSP 70-related proteins constitutively expressed during oogenesis and embryogenesis in the amphibian Xenopus laevis. Our results provided evidence for a regional localization in oocytes. In embryos, the regional distribution observed in o... |
Scoliosis screening has been practiced for nearly 50 years and has provided valuable knowledge about the prevalence and natural history of scoliosis. Early diagnosis allows for nonoperative treatment, like wearing an orthosis that has been shown to be effective by numerous outcome studies. Challenges in scoliosis scree... |
Apoptosis is critical to the progression of human immunodeficiency virus-1 (HIV-1) infection. It appears reasonable that antiretroviral therapies may not achieve a full control of the infection in the absence of an impact on apoptosis. We assigned 20 asymptomatic HIV-infected subjects with advanced immunodeficiency to ... |
The impact of test conditions on the detectability of open defects is investigated. We performed an inductive fault analysis on representative standard gates. The simulation results show that open-like defects result in a wide range of different voltage-delay dependencies, ranging from a strongly increasing to a strong... |
Is the work of software predominantly clerical, intellectual, or creative? A number of opinions on the issue presently co-exist in the field, and they cannot all be valid: software is trivial to build; software construction is automatable; software construction is the most complex activity ever undertaken by humanity; ... |
The stability of foods strongly depends on the state of water (i.e. water activity) and temperature. Agaricus bisporus mushroom plays an important role as a nutritional and functional food; however little information is available on the effect of processing on its stability. This study measures the thermal characterist... |
The E760 collaboration performed an experiment in the Antiproton Accumulator at Fermilab to study the two photon decay of the q,( I’&) charmonium state formed in pp annihilations. This resulted in a new measurement of the mass, IL& = 2988.3fz::MeV/c2 and of of the product B(Q + pp) x I’(Q + 77) = (S.l+~:~) eV. We perfo... |
Although much has been written about better aligning Information Systems (IS) with the business, too often organizations perceive software development as though it exists in its own little cocoon. Selection of a formal software development methodology (FSDM) is usually left to the IS area which focuses on the detail co... |
This is a very exciting time for medicine. We are witnessing the creation of a new approach to the prevention and treatment of cardiovascular disease. It is an omnigenic approach-powered by systems biology-to assembling patient-specific information about how genes and lifestyle interact. When combined with other new te... |
Noncoherent receivers are used for frequency-selective fading channels where the estimation of channel is difficult. The channel estimation can be more cumbersome for asynchronous code division multiple access (A-CDMA) systems due to multiaccess interference. A noncoherent reduced rank receiver which has less complexit... |
In order to reduce the cost of the production cycle, the economic design of EWMA charts with variable sampling interval (VSI) under non-normality is discussed in this paper. First, using the Burr distribution to approximate various non-normal distributions, the optimal values of the test parameters for the VSI EWMA cha... |
The role of silicon as a corrosion inhibitant was investigated by determining the concentration profiles of silicon and the other associated elements in the Commercial Advanced Gas Cooled Reactor (CAGR) material. The microbeam scanning method was employed. Three different alloys namely Fe-9Cr, Fe-9Cr -0.3%Si and Fe-9Cr... |
Since the last H-mode workshop in 1991, there has been significant progress in a number of areas. In addition to H-modes in tokamaks, H-mode has been achieved in a current-free stellarator, a heliotron/torsatron with some net toroidal current and in a linear, tandem mirror. Because H-mode has been seen in a variety of ... |
Ephedrine, a sympathomimetic drug, may stimulate the central nervous system via its amphetamine‐like effect under light general anaesthesia. We compared the effect of ephedrine on auditory‐evoked potentials with that of etilefrine, a sympathomimetic drug that lacks an amphetamine‐like effect, in patients undergoing abd... |
Smartphone apps market is a billion dollar industry and is growing rapidly. Thus, app developers are constantly on the lookout for efficient and reliable data analytics and prioritization tools that analyze crucial feedback present in app reviews and at the same instance prioritize the reviews for remedial actions. Suc... |
Individuals with cognitive impairment often represent a significant percentage of the residents in a nursing home nurse's care. With years of experience caring for their placed family members, caregivers of these residents are often experts in knowing the resident's needs, habits, behaviors, and moods. Caregivers often... |
Successful weed control is essential for economical corn production in Florida. Weeds reduce corn yields by competing for moisture, nutrients, and light during the growing season and interfere with harvest. Producing a good corn crop is only half the battle and will not be profitable unless the corn can be harvested. L... |
Despite the fact that the United Nations Guiding Principles on Business and Human Rights (UNGPs) have specific provisions that are applicable to States to ensure that businesses that are owned or controlled by the State, or that enter into transactions with the State, respect human rights; most scholarship, so far, see... |
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