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The aim of this study was to evaluate quality of life (QOL) in a group of elderly patients (> 65 years) with aggressive non-Hodgkin's lymphoma (NHL) treated with chemotherapy regimens containing anthracyclines. |
DESIGN AND METHODS |
QOL was evaluated in a population of elderly patients with aggressive NHL enrolled in a phase III clinical trial run by the Intergruppo Italiano Linfomi (IIL) from 1996 to 1999 to compare two different anthracycline-containing regimens (mini-CEOP vs P-VEBEC). The EORTC-QLQ-C30 questionnaire, which has already been vali... |
RESULTS |
Ninety-one patients completed pre-therapy and post-therapy questionnaires and they are the subject of this report. Baseline QOL assessment showed a strong correlation of poor values of QOL with anemia and high risk according to the International Prognostic Index (IPI). At the end of treatment no functional scales showe... |
INTERPRETATION AND CONCLUSIONS |
The EORTC-QLQ-C30 is feasible even in a population of elderly patients, in whom it had never been tested before. The improvement of QOL at the end of the treatment demonstrated that the symptoms of the disease have a greater negative influence on the patient's life than do the side effects of the therapy.Organizational... |
The widely held contemporary perspective on entrepreneurship is dangerously premature. Currently existing theories are insufficient to understand the dynamic interplay among entrepreneurship, the state, and external environment forces, as well as the organization's capacity to facilitate entrepreneurship and resulting ... |
In order to analyze the making arc characteristics of AgSnO2 contact, experiments were carried out with a self-developed experimental equipment. It was found that contact resistance had no obvious change with the increase of the number of experiments.In the later stage of the experiment, the contact bounces occurred du... |
Kindling refers to a phenomenon where an initially subthreshoid electrical stimulation applied repeatedly (daily) to the different brain structures results in the progressive development of electroclinical seizures terminating in a generalized convulsion (4, 6). It has been suggested that the kindling effect may be emp... |
OBJECTIVE |
To assess the clinical and economic consequences of oral atypical antipsychotic treatment (aripiprazole, olanzapine, paliperidone ER, quetiapine, risperidone, and ziprasidone) in schizophrenia over one-year from a US healthcare system perspective. |
METHODS |
The decision model captured rates of discontinuation, symptom response, frequency and duration of relapse, adverse events (extrapyramidal symptoms and weight gain), resource utilization, and unit costs. Published randomized, double-blind, placebo-controlled clinical trial data were used to obtain response rates for com... |
RESULTS |
The model estimated that, over 1 year, clinical outcomes of patients administered oral atypical antipsychotics would not vary considerably. This is partly due to differences 'washing out' because of frequent switching and discontinuation of medication. Economic outcomes did vary among pharmacotherapies: paliperidone ER... |
CONCLUSION |
This modeling study showed that paliperidone ER had the most favorable clinical and economic outcomes compared to other oral atypical antipsychotics for patients with schizophrenia. The analysis supports the notion that frequent discontinuation of medication is a problem with all oral antipsychotic treatments for schiz... |
SUMMARY Enzyme-linked immunosorbent assay (ELISA) tests were used to measure IgG antibody levels in 2638 New Zealand children who had been immunized with the triple vaccine DTP. The percentage of children immune to diphtheria decreased with age. The percentage of children immune to tetanus varied from 67.1 to 55.0%. Th... |
Purpose of review This review focuses on the recent technological advances in quantitative sodium (23Na) MRI to provide a noninvasive measure of tissue viability for use in clinical studies of patients with kidney disease. 23Na MRI is the only noninvasive imaging technique that allows for the absolute spatial quantific... |
What is the relation between the intention to A and doing A intentionally? It is natural to suppose that the latter entails the former. That is, it is natural to accept what Michael Bratman has called the ‘Simple View’ of the relation between acting intentionally and having an intention. Bratman is one noteworthy write... |
In the preceding eight Studies, I we have presented the results of fieldwork in all the regions of Spain and Portugal where there are major concentrations of (mostly Neolithic) communal tombs. The great majority of the tombs are megalithic, constructed (mainly in the fourth or third millennia) out of a small number of ... |
Since at least the mid-1990s the question of disclosure about the health of executives of public companies has been the subject of scholarly commentary and the popular business press. Notwithstanding some proposals for SEC rulemaking in this area, nothing has been proposed by the SEC, and none seems to be likely. Thus,... |
This Article summarizes those basic principles, discusses how they may apply to issues of material facts regarding executive health, and concludes by proposing some best practices in the absence of specific guidance from the SEC.Therapeutic effects of Sophora moorcroftiana alkaloids in combination with albendazole in m... |
The objective of the present study was to determine if the combination of alkaloids from Sophora moorcroftiana seeds and albendazole might be effective in the treatment of experimental echinococcosisin female NIH mice (6 weeks old and weighing 18-20 g, N = 8 in each group) infected withprotoscolices of Echinococcus gra... |
In this paper, we derive a class of alternating group explicit finite difference method (AGE) for diffusion equations based on eight asymmetric schemes and the concept of domain decomposition. The AGE method is verified to be unconditionally stable, and has the property of parallelism. Results of numerical examples sho... |
Two conjugated polymers, with different side chains of alkoxy-substituted difluorobenzene and alkyl-substituted difluorobenzene based on quinoxaline (Qx) as the electron acceptor unit and benzodithiophene as the electron donor unit, named HFQx-T and HFAQx-T, were used as electron donor polymers to fabricate all-polymer... |
Diabetes is associated with an increased risk for a number of serious, sometimes life‐threatening complications. It is a loss of beta‐cell function and/or mass that eventually defines the disease. Glucose, the main regulator of insulin secretion and production, exerts negative effects on beta‐cell function when present... |
The control subsystem for the Atacama Large Millimeter Array (ALMA) must fulfill a number of roles. Principle amongst these is the ability to conduct observations and the ability to monitor and maintain the health of the hardware. These two roles impose different requirements on the control subsystem. The ALMA control ... |
Several key episodes of the development of Soviet acoustics in the crucial years for the country are described. They are related to the scientific activities of the founder of Soviet acoustics, N. N. Andreyev, whose 140th birthday is celebrated in 2020. Organizational aspects of large Soviet projects in the field of ai... |
An adult female pigtail macaque was evaluated for acute flaccid rear limb paralysis with reduced patellar and anal reflexes. Despite supportive care, antibiotics, and corticosteroids, the monkey showed no improvement and was euthanized 7 days after the onset of clinical signs. Necropsy revealed a soft and swollen spina... |
This paper examines the dynamic relationships that exist between output growth and unemployment and assesses the role of macroeconomic policies in shaping these relationships. Using Nigeria’s data for the period 1970-2010, we first estimated the linear Okun-type model using the transitory and permanent components of th... |
Three successive (representative) values of fluorescein‐instillation TBUT (tear break‐up time) were obtained from a group of young Hong Kong (HK)‐Chinese. The median TBUT1, TBUT2 and TBUT3 were 3.2, 3.8 and 4.5 sec, respectively. Wilcoxon signed‐rank tests showed that TBUT1 was significantly different from TBUT2 and TB... |
The design and the debugging of large distributed AI systems require abstraction tools to build tractable macroscopic descriptions. Data aggregation provides such tools by partitioning the system dimensions into aggregated pieces of information. Since this process leads to information losses, the partitions should be c... |
1002 ★ Instead, he kept a private intelligence service run by the journalist John Franklin Carter. Among the persons he employed were some with strange histories like ex-Nazi Ernst “Putzi” Hanfstaengl. One theme given special consideration is the OSS outpost in the Swiss capital of Bern, which Allen Dulles had taken ov... |
In vitro ultraviolet B (UVB) irradiation of human blood monocytes inhibits their accessory cell function for antigen- and mitogen-induced T cell responses. These studies were designed to characterize the nature of the UVB-induced defect in human monocyte accessory cell function. Irradiated monocytes were deficient in t... |
Amoxicillin (AMX) is one of the most commonly prescribed antibiotics around the world due to its broad‐spectrum activity against different bacterial strains as well as its use as a growth promoter in animal husbandry. Although residues of this antibacterial agent have been found in water bodies in diverse countries, th... |
Experiments in which collection efficiencies have been measured for small droplets falling through a sheared air flow are described. The results indicate that these collection efficiencies are much greater than for the same droplets falling in still air when the collecting droplets are less than about 25μm in radius, b... |
Visible-near infrared (NIR) spectra of kiwifruit berries were processed by discriminant analysis techniques to differentiate berries treated during on-vine development. Treatments applied were leaf removal or shading berries with aluminium foil through crop development, or dipping the berries in ethephon two weeks prio... |
Sequence analysis of 285 nucleotides located on the variable part of the N gene was undertaken on measles virus (MV) samples collected from acutely infected patients in Germany, the Czech Republic, Denmark, Poland, and Russia. Two distinct genotypes (C2 and D6) have circulated in Germany between 1993 and 1996. Isolates... |
Introduction Osteoarthritis is a leading cause of global disability and is set to worsen with the concurrent rise in rates of obesity and an ageing population [1]. Current clinical solutions are sub-optimal with regards to their invasiveness and outcomes. Orthopaedic biologics is an emerging field that offers alternati... |
1Key Laboratory of South China Sea Fishery Resources Exploitation and Utilization, Ministry of Agriculture and Rural Affairs; South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, 510300, Guangzhou, Guangdong Province, China 2College of Fisheries, Tianjin Agricultural University, 300392, Ti... |
Discounted cash flow (DCF) is the most accepted approach for company valuation. However, the DCF approach presents a number of serious weaknesses within the internet companies' context. One of these weaknesses is tackling the uncertainty that characterise future cash flows of these companies. This paper looks at the wa... |
Welcome to the 40th Annual International ACM SIGIR Conference on Research and Development in Information Retrieval (SIGIR 2017). SIGIR is the premier scientific conference in the broad area of information retrieval. We received a high-quality set of full-paper submissions to consider for inclusion in the conference pro... |
We reviewed 362 papers for the full paper track, and accepted 78, for an acceptance rate of 22%. In total, there were 1056 authors from 42 countries: 299 from China, 232 from the United States, and 525 from the rest of the world. The countries (with at least 10 submissions) with the highest acceptance rates were the Un... |
We made several modifications to the paper submission and review process for SIGIR 2017. We transitioned to EasyChair, one of three conference submission applications supported by ACM. We significantly updated the call for papers to broaden the range of topics considered in scope for the conference, and more accurately... |
We ran an in-person SPC meeting at Microsoft in Redmond, WA. To allow more SPC members to take part, we enabled remote participation via video conference. Approximately half of the SPC participated, either in person or remotely. SPC members were asked to submit their full-paper recommendations prior to the meeting. Dur... |
The short paper track received a record number of 398 submissions and accepted 121 (30%) of them. The track was chaired by Hui Fang, Mounia Lalmas and Yiqun Liu. |
The demo paper track received 36 submissions and accepted 17 (47%) of them. The track was chaired by Gareth Jones and Takehiro Yamamoto. |
The SIGIR Symposium on IR in Practice (SIRIP 2017) had seven invited talks and five accepted regular papers. The track was chaired by Sumio Fujita and Vanessa Murdock. |
The doctoral consortium track received 14 submissions of which 9 (64%) were accepted. The track was chaired by Makoto P. Kato and Kira Radinsky. |
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