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Many studies have found that ruthenium complexes have unique biochemical characteristics and thus inhibit tumor growth or metastasis. Our aim was to report a novel dual-targeting ruthenium candidate 2b with both antitumor and antimetastatic functions that could target tumor sites using both EPR effects and TF/TFR. It ... |
Augmented reality (AR) technologies start to be mature enough to be used in industrial work settings. However, human factors and ergonomics (HFE) and safety issues have not been considered thoroughly yet. The purpose of this study was to identify what kind of postures users adopt when using a tablet based AR system dur... |
Kernel based learning has already found wide applications to solve several data mining problems. In this paper, we proposed an improved linear kernel with automatic smoothing parameter (Sp) selection compared to the classical approach. Experiment results using some classification related benchmark datasets reveal that ... |
Scientists have called for urgent action after the abrupt withdrawal by drug companies from research into treatments for brain disorders. |
In the past year a number of drug companies, including GlaxoSmithKline and AstraZeneca, have pulled out of neuroscience research in Europe because they see it as economically unviable. Furthermore, levels of European Union research funding into mental disorders and diseases of the brain have been low in comparison with... |
A report from the European College of Neuropsychopharmacology, published this week, makes a number of recommendations. |
It calls for the regulatory process to be reviewed to encourage more and better trials in psychiatry and for incentives to be offered to drug companies, such as extending the life of patents on new drugs for brain disorders. …LACIS-measurements and parameterization of sea-salt particle hygroscopic growth and activation |
The Leipzig Aerosol Cloud Interaction Simulator (LACIS) was used to investigate the hygroscopic growth and activation of sea-salt particles which were generated from three different sea-water samples. The measurements showed that the sea-salt particles exhibit a slightly reduced hygroscopic growth compared to pure NaCl... |
Many tissues fold during development into complex shapes. Engineering this process in vitro would represent an important advance for tissue engineering. We use embryonic tissue explants, finite element modeling, and 3D cell patterning techniques to show that a mechanical compaction of the ECM during mesenchymal condens... |
A study was made of the effect of a 30-day administration of various doses of testosterone-propionate and methyltestosterone to intact female rats given a ration rich in protein on the activity of acid DNA-ase, RNA-ase and proteinases in the liver and the blood serum. The ration itself, rich in proteins, increased the ... |
We present a fuzzy (or quantitative) version of the van Benthem theorem, which characterizes propositional modal logic as the bisimulation-invariant fragment of first-order logic. Specifically, we consider a first-order fuzzy predicate logic along with its modal fragment, and show that the fuzzy first-order formulas th... |
Transanal endorectal pull-through (TAEPT) surgery is primarily performed for rectosigmoid aganglionosis, generally with excellent results. There is evidence that overstretching the anus and tension traction in the sigmoid during the procedure could impair the final continence of the patient. Many researchers suggest th... |
The inventory management system plays a vital role in a pharmaceutical industry. For every business, managing an inventory is important whether it is small or big, domestic or international business. In a pharmaceutical company, the raw materials have an expiry date associated with them so it becomes important to set a... |
Keywords: Inventory, Perishable items, Pharmaceutical inventory, RFID technology, Drug inventoryAll-optical packet-switched interconnection network based on modular photonic digital processing |
Future interconnection networks will be required to achieve ultra-high bandwidth and low latency communications to cope with the increasing performance requirements of backbone routers, large data storage systems and supercomputing systems. Aiming at achieving ultra-high bandwidth communications and approaching optical... |
This study assesses the interrelationships between terrace development and topographic factors, soil erosion, and soil dislocation by tillage in Minchet Catchment in the Ethiopian Highlands. Data were collected through a mix of modelling soil erosion using the Universal Soil Loss Equation adapted to Ethiopia, and measu... |
Abstract Objective : The purpose of this study was to evaluate prospectively Magnetic Resonance Imaging (MRI) for the preoperative localization of hyperfunctioning parathyroid glands. Design : Prospective study of 58 consecutive patients with biochemically confirmed primary hyperparathyroidism who underwent preoperativ... |
Clinical studies examining the combination of paclitaxel (PTX) and everolimus (EVER), an mTOR inhibitor, have failed to result in significant improvements in efficacy and toxicity in patients with breast cancer (BC), relative to treatment with PTX alone. These disappointing clinical trial results have been attributed t... |
Distributed Denial of Service (DDoS) attacks can be so powerful that they |
can easily deplete the computing resources or bandwidth of the potential targets, by flooding massive packets. Internet infrastructures and network applications, including social services and communication systems for emergency management, are under the threat of the DDoS problem. This thesis aims at providing efficien... |
Dealing with DDoS attacks is challenging, due to their multifaceted properties: dynamic attack rates, various kinds of targets, big scale of botnets, etc. Multifaceted nature of DDoS attacks justifies the need for multifaceted defense. Thus we address the DDoS problems from different aspects. In particular, in the thes... |
network. By building on earlier work and improving on distribution of control aspects, a proactive method, which we call CluB, is proposed in this thesis to mitigate DDoS attacks. The method |
balances the effectiveness-overhead trade-off by addressing the issue of |
granularity of control in the network. |
CluB can collaborate with different routing policies in the network, |
including contemporary datagram options. We estimate the effectiveness of the method and also study a set of |
factors for tuning the granularity of control. The thesis also studies the problem of monitoring high-speed traffic and detecting DDoS-related anomalies in a data streaming fashion to offer a detection at an early stage in the core network, thus activating appropriate DDoS mitigations only when necessary. We propose an... |
In-line venous saturation monitoring is a useful method of quality management during extracorporeal circulation (ECC). The Bentley SM-0200 OxySAT® meter was tested with and without the use of the recommended cuvette. The study consisted of an in vitro part, where extremely low saturations could be safely measured, and ... |
Dysregulated expression of bone morphogenetic protein receptor type II (BMPR2) is a pathogenetic hallmark of pulmonary hypertension. Downregulation of BMPR2 protein but not mRNA has been observed in multiple animal models mimicking the disease, indicating a posttranscriptional mechanism of regulation. Because microRNAs... |
A case is presented that the field of psychotherapy has some embarrassing problems that are collectively denied and that it is important for the field to admit they exist so that steps can be taken toward their resolution. A provisional list of 11 problems is proposed, together with suggested avenues toward solution. T... |
The Individuals with Disabilities Education Improvement Act of 2004 mandates that students with disabilities graduating or aging out of the P—12 school system be provided with a summary of academic achievement and functional performance (SOP). The SOP should provide the student with one document that summarizes availab... |
Fine-grained communication in supercomputing applications often limits performance through high communication overhead and poor utilization of network bandwidth. This paper presents Topological Routing and Aggregation Module (TRAM), a library that optimizes fine-grained communication performance by routing and dynamica... |
We have designed, fabricated and tested self-aligned angular vertical comb-drive (AVC) actuators by on-chip assembly technique using in-plane electrothermal actuators. The AVC actuators are fabricated on a silicon-on-insulator (SOI) wafer using three photomasks and three times of deep etching steps. The maximum optical... |
To develop a new method of screening chest radiography that would provide respiratory kinetics easily and automatically using flat-panel-detector capacitated fluoroscopy, we carried out a motion analysis of the diaphragm at several respiratory phases. We obtained five chest radiographs of healthy volunteer at five resp... |
Abstract Four C-13, C-14 side chain modified 9(R)-hydroxy-1-deoxy-taxane analogues 15, 16, 19 and 22 were semi-synthesized from 1-deoxybaccatin VI. The in vitro antitumor activity of these compounds was evaluated against A549 and A2780 cell lines. The preliminary SAR analysis showed that introduction of oxygen-containi... |
OBJECTIVE |
To assess the differential effects of antiepileptic drugs (AEDs) on hepatic enzyme and thyroid hormone levels and to assess the frequency and degree of these alterations. |
STUDY DESIGN |
Retrospective analysis of hepatic enzyme (serum aspartate aminotransferase and alanine aminotransferase) and thyroid hormone (thyroxine, T uptake; and free thyroxine index) levels obtained during a 10-year period in a large unselected outpatient population of patients with epilepsy. |
PATIENTS |
Unselected (for age, sex, race, type of epilepsy, or degree of control) epileptic subjects (n = 642 for determination of hepatic enzyme levels and n = 317 for determination of thyroid hormone levels) attending the largest outpatient epilepsy center in the Midwest. Infants (younger than 1 year) and those receiving more ... |
OUTCOME MEASURE |
Hepatic enzyme and thyroid hormone level alterations vis-à-vis the type of AED, serum AED levels, and monotherapy vs bitherapy. |
RESULTS |
Aspartate aminotransferase level alterations were mainly due to valproate or phenobarbital, and alanine aminotransferase alterations were due to phenytoin. Significant enzyme level elevations were infrequent (2% [14/642] of patients), mild, usually associated with bitherapy, transient, and confined to aspartate aminotr... |
CONCLUSIONS |
Antiepileptic drugs affect hepatic enzyme and thyroid hormone levels differentially, and bitherapy alters them more than monotherapy does. However, alterations are mostly mild and clinically insignificant and do not justify routine testing, except in those known to have a coexisting hepatic or thyroid abnormality, thos... |
Mathematical communication skills are the ability to convey mathematical ideas or ideas orally or in writing, and to understand and accept other people's ideas or ideas carefully, analytically, critically, and evaluative to sharpen the understanding. The purpose of this study is to analyze students ' mathematical commu... |
In this paper, ultrasound contrast agents based on a high molecular polymer-poly lactic acid (PLA) and loaded with hydroxycamptothecin (HCPT) were prepared by combining ultrasound method and a Shirasu porous glass (SPG) membrane emulsification technique. A special focus was on the optimization of production of HCPT-PLA... |
Laboratory‐confirmed influenza is a nationally notifiable disease in Australia. According to notification data, Queensland has experienced more severe influenza seasons than other states and territories. However, this method ignores available denominator data: the number of laboratory tests performed. We propose that n... |
A practical, enantioselective synthetic route to a key precursor to the tetracycline antibiotics is reported. The route proceeds in nine steps (21% yield) from the commercial substance methyl 3-hydroxy-5-isoxazolecarboxylate. Key steps in the route involve enantioselective addition of divinylzinc to 3-benzyloxy-5-isoxa... |
Small cells (SCs) mounted on top of Unmanned Aerial Vehicles (UAVs) can be used to boost the radio capacity in hotspot zones. However, UAV-SCs are subject to tight battery constraints, resulting in frequent recharges operated at the ground sites. To meet the UAV-SCs energy demanded to the ground sites, the operator lev... |
Enhanced Recovery after Surgery (ERAS) protocols have been demonstrated to improve hospital length of stay and outcomes in patients undergoing colorectal surgery. This article presents the specific components of an ERAS protocol implemented at the authors' institution. In particular, details of both surgical and anesth... |
Extensive research has characterized ginger's anti‐inflammatory, antioxidant, and antitumor activities. Shogaols, a series of major constituents in dried ginger with the most abundant being [6]‐, [8]‐, and [10]‐shogaols, show much higher anti‐cancer potencies than gingerols. Previously, we reported the mercapturic acid... |
Scholars from the configuration school have suggested that businesses do well only when they are well-configured. Specifically, they have argued that businesses must first, match organizational priorities and practices to their chosen strategy; second, strike an appropriate balance so that no priority reaches dangerous... |
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