text stringlengths 0 10.1k |
|---|
Two studies find that the small molecule ONC201 induces cancer cell death through cellular stress–related pathways. The small molecule ONC201 was identified in a screen for compounds that would induce expression of the gene encoding tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) in tumors and thus caus... |
The author offers observations on the nature of pathological dissociation, emphasizing the compartmentalization of unsymbolized affective experience. The irrelevance of personal agency and intentionality in the pathogenesis of dissociative psychopathology along with the deficiency in symbolization that is a sequela of ... |
Present information suggests that endogenous prostaglandins, hormonal factors, and neuropeptides participate in the regulation of duodenal bicarbonate secretion in response to luminal hydrochloric acid. The purpose of this study was to examine the effects of cholinergic antagonists and agonists on basal and acid-stimul... |
The susceptibilities of 40 recent Belgian field isolates of Mycoplasma bovis to 10 antimicrobial agents were assessed. Tiamulin was the most active antimicrobial agent against M bovis, with an initial inhibitory concentration (IIC50) of 0-06 μg/ml, but it is not licensed for the treatment of cattle. All three fluoroqui... |
PREMISE OF THE STUDY |
Mountain plants are among the species most vulnerable to global warming, because of their isolation, narrow geographic distribution, and limited geographic range shifts. Stochastic and selective processes can act on the genome, modulating genetic structure and diversity. Fragmentation and historical processes also have... |
METHODS |
Genetic structure, diversity, and loci under selection were analyzed using AFLP markers in 17 populations distributed over the whole geographic range of Armeria caespitosa, an endemic plant that inhabits isolated mountains (Sierra de Guadarrama, Spain). Differences in altitude, geographic location, and climate conditio... |
KEY RESULTS |
Bayesian clustering approaches identified nine genetic groups, although some discrepancies in assignment were found between alternative analyses. Spatially explicit analyses showed a weak relationship between genetic parameters and spatial or environmental distances. However, a large proportion of outlier loci were det... |
CONCLUSIONS |
A. caespitosa populations exhibit spatial patterns of genetic structure that cannot be explained by the isolation-by-distance model. Shifts along the altitude gradient in response to Pleistocene climatic oscillations and environmentally mediated selective forces might explain the resulting structure and genetic diversi... |
Microcrystals with defined sizes, morphologies, and locations provide a core opportunity for applications in microelectronic devices and microoptical components. Herein, a simple method was developed to obtain microcrystals with controlled sizes and locations by capillary-assisted localized crystallization, which utili... |
Face cognition is considered a specific human ability, clearly differentiable from general cognitive functioning. Its specificity is primarily supported by cognitive-experimental and neuroimaging research, but recently also from an individual differences perspective. However, no comprehensive behavioral data are availa... |
Conflicts are an integral part of communications, both interpersonal and professional, it can be both constructive and destructive. It depends on many factors, primarily on the participants’ proneness to conflict and empathy. The presented scientific problem is important because empathy is important for resolving of pr... |
This study presents a radiative transfer process and machine learning combined method to estimate the crown foliage fuel load (FFL), an important factor influencing the characteristics of crown fires. To this end, the GeoSail, SAIL and PROSPECT radiative transfer models (RTMs) were firstly coupled together to simulate ... |
BACKGROUND |
We studied whether quantification of serum HBsAg and HBV DNA levels could predict spontaneous HBsAg clearance in patients with negative hepatitis B e antigen (HBeAg). |
METHODS |
Serum HBsAg and HBV DNA levels were measured at baseline among a longitudinal cohort of 103 HBeAg-negative patients recruited since 1997. |
RESULTS |
Twelve (12%) patients developed HBsAg seroclearance after 88 ± 26 months (range, 21-139) of follow-up. At baseline, the serum HBsAg level among patients who cleared HBsAg (1.30 ± 1.27 log IU/mL) was significantly lower than those who did not clear HBsAg (2.96 ± 0.84 log IU/mL; P < .001). The area under receiver operati... |
CONCLUSIONS |
Single-point serum HBsAg level can predict the chance of HBsAg seroclearance in chronic hepatitis B patients with negative HBeAg.Quantity-Based Price Discrimination Using Frequency Reward Programs |
This paper explores the quantity-based price discrimination and switching costs effects of reward programs by analyzing individual level choice data of participants of a frequent golfer program. Golf provides a setting to evaluate reward programs that are not designed to exploit a principal agent problem, as is likely ... |
Due to the recent explosive progress of WWW (World-Wide Web), we can easily access a large number of images from WWW. However, methods to utilize WWW as a large image database have not been established yet. In this paper, we propose an automatic image-gathering system from WWW employing both keywords and image features... |
In a previous paper, we modeled the oscillations of a thermally supported (Bonnor-Ebert) sphere as nonradial, linear perturbations following a standard analysis developed for stellar pulsations. The predicted column density variations and molecular spectral line profiles are similar to those observed in the Bok globule... |
This research aims to investigate the students’ interest in learning English towards the use of Quipper School. In this study, 45-eighth-grade students from three classes at Lab SMP School Unismuh Makassar responded to 20-items of the questionnaire about the use of Quipper School in learning English. The data were then... |
Most churches intercede every Sunday in their public worship for the needs of the world and for their fellow members. However, it seems that some topics are consistently left out from the prayers, such as prayers for mental health. This article addresses the question whether some topics are taboo, by investigating what... |
Over the last decade, molecular biology has progressively developed, leading to new technology with subsequent clinical application for various cerebral diseases including Parkinson's disease (PD), one of the most investigated neurodegenerative disorders. The therapy for PD is mainly composed of medication, including d... |
A rapid reversed passive latex agglutination method that uses high-density latex particles for the detection of staphylococcal enterotoxins (SE) A to E was developed. It took 3 h for incubation, much less than the 16 h needed with a customary latex agglutination test for SE detection such as a commercial test kit (SET-... |
More than 10% of the people in the world still suffer from inadequate access to clean water. Traditional water disinfection methods (e.g., chlorination and ultraviolet radiation) include concerns about the formation of carcinogenic disinfection byproducts (DBPs), pathogen reactivation, and/or excessive energy consumpti... |
One of the open issues in Model Driven Architecture (MDA) is how to automatically transform the Platform Independent Model (PIM) over the Platform Specific Model (PSM) into source code currently this is only possible for a few domains using UML profiles, but the major goal is to minimize the required interaction by the... |
Big displays and ultrawalls are increasingly present in nowadays environments (e.g. in city spaces, buildings, transportation means, teaching rooms, operation rooms, convention centres, etc.), at the same time that they are widely used as tools for collaborative work, monitoring and control in many other contexts. How ... |
Through exponential sample-size scaling of conductance, we demonstrate strong electron localization in three sets of nanostructured antidot graphene samples with localization lengths of 1.1, 2, and 3.4 μm. The large-scale mesoscopic transport is manifest as a parallel conduction channel to 2D variable range hopping, wi... |
This article describes a civic engagement and service learning living-learning community on a dedicated floor in a university residence hall. Students volunteered to live with one another while concurrently enrolled in social work service-learning courses. Student assessment of the combined affect service learning and ... |
This paper analyses the transformation of identities and institutions of economic experts as politico-economic professionals brought about by the Brexit process between 2016 and 2020. In order to understand the transformation from order to chaos in times of COVID-19, a mixed methods approach is applied. In a first step... |
An ab anitio SCF–LCAO–MO study of nonadditive three‐ and four‐body interaction energies in Mg3 (equilateral and linear) and Mg4 (tetrahedral) clusters is presented. The relative importance of these few‐body terms to the interaction energy is at most 39% for three‐ and 8% for four‐body terms. This lies in marked contras... |
UNLABELLED |
The purpose of this study consisted of the evaluation of some sexually transmitted diseases in patients with cervical pathology, namely squamous intraepithelial lesions. |
METHODS |
a prospective study was performed. Patients with an abnormal cervical smear were submitted to colposcopy, directed biopsy and an immunologic assay for Chlamydia, Herpes Simplex Virus (HSV) types 1 and 2, Cytomegalovirus, Treponema pallidum, Hepatitis B and Human Immunodeficiency Virus I and II. The same parameters were... |
RESULTS |
118 patients were separated into four groups. Statistically significant differences were observed in the personal history of fungi infections, as well as Chlamydia and HSV 2 IgM. |
CONCLUSION |
immunologic assays may prove useful in identifying sexually-transmitted diseases, especially Chlamydia and HSV 2 infections, in Human Papillomavirus infected women.The precise breakpoints of a Filipino-type alpha-thalassemia-1 deletion found in two Japanese. |
The breakpoints of alpha-thalassemia-1 were thoroughly characterized in two Japanese families. The crossover occurred between Alu repeats at about 1.28 kb 5' to the zeta2 gene and about 1.2 kb 3' to the theta1 gene, resulting in the deletion of a 30.656 kb-long segment. These breakpoints are consistent with those surmi... |
ABSTRACT University social work programs can play a critical role in helping communities to expand local capacity in efforts to end homelessness. The Supplemental Security Income/Social Security Disability Insurance (SSI/SSDI) Outreach, Access and Recovery (SOAR) program is an evidence-based model that social work prog... |
Mobile technology is revolutionizing the way companies do business, by improving business processes, increasing productivity and enhancing customer experience. Hence the need to manage/monitor the mobile phones has never been higher. Simple Networking Management Protocol (SNMP), is an internet standard protocol for man... |
In theory, scientific discovery follows the path of putting forward a hypothesis, testing it and either accepting it as a theory or discarding it based on the outcome of testing. As it often happens, real life is more complicated than this straightforward scheme; research undergoes unexpected twists and turns, and the ... |
This paper focuses on the mitigation of porpoising instability of high-speed planing vessels using controllable transom flap and dynamic feedback. A control oriented model that captures both steady-state and dynamic characteristics is presented and used to facilitate the model-based control design. A nonlinear controll... |
At present, in the thermal power stations, it always cost a lost to operate the boiler combustion system and the flue gas denitrification system. Under the premise in standard emission, it can improve the power units’ economic performance by optimizing the comprehensive operating cost of the boiler combustion system an... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.