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INTRODUCTION |
Depression can impact quality of life, functioning, and treatment adherence. However, depression in persons with hemophilia A (PwHA) is not uniformly examined nationwide. We report on depression and treatment-related hemophilia symptoms and utilization in a sample from six geographically representative U.S. Hemophilia... |
METHODS |
Hematology Utilization Group Studies part Va (HUGS Va, 2005-2007) was an observational study that collected data on sociodemographics and 12-Item Short Form Health Survey (SF-12) via patient survey, and clinical characteristics via medical chart review for adults (≥18 years old) with hemophilia A. Depressive disorders... |
RESULTS |
The analysis included 147 adults with mean age 33.0±12.5 years old, 64% with severe hemophilia. Using the criteria of MCS≤45, 27.9% of sample had depressive disorder, and 10.2% had more severe depression at MCS≤36, higher than the 9.0% prevalence of current depression in the general U.S. population studied by CDC's Be... |
CONCLUSIONS This sample of PwHA reported higher rates of potentially depressive disorders than the general USA population. Lower educational levels, joint problems, and barriers to accessing care may be high-risk factors for depressive disorders. |
Wu: Baxalta US Inc., Bannockburn, IL (a Takeda Company), CSL Behring L.L.C., and Octapharma USA, Inc.: Research Funding. Curtis:USC Hemophilia Utilization Group Study (HUGS): Consultancy; Patient Reported Outcomes, Burdens and Experiences: Consultancy; Bayer: Consultancy; Novo Nordisk: Consultancy. Tran:Bayer: Consult... |
External memory interface for RISC controller on reconfigurable hardware logic |
Development in VLSI technology and its implementation leading to optimization of various systems related with prime parameters such as power, speed and area has been achieved. As the consumer electronics market is growing very rapidly, RISC processors with additional features required to be implemented are also demandi... |
never had a clear edge over those who were "planners" (along the lines of the British Laborites) concerning Europe's future. Kindleberger's long Chapter 11 is a careful review of the "level of industry problem" and of the evolving policies concerning the effect on Germany of her reparations payments. Scholars who have ... |
Our objectives were to 1) determine how growth state and cell density affect the expression of the smooth muscle (SM) and nonmuscle (NM) isoforms of the 20-kDa myosin regulatory light chains (MLC20) in cultured rat aortic smooth muscle cells (SMC) and 2) to determine whether angiotensin II stimulates differential phosp... |
Microelectronics is the dominant industrial technology of today. Its rate of innovation, spelled out by Moore's Law, is exceptional by any commercial metric, especially, as it has been on this trajectory for almost 40 years. It is not surprising, that other industrial sectors are taking advantage of the innovation engi... |
OBJECTIVE |
The research studied the status of hospital librarians and library services to better inform the Medical Library Association's advocacy activities. |
METHODS |
The Vital Pathways Survey Subcommittee of the Task Force on Vital Pathways for Hospital Librarians distributed a web-based survey to hospital librarians and academic health sciences library directors. The survey results were compared to data collected in a 1989 survey of hospital libraries by the American Hospital Asso... |
RESULTS |
The greatest change in library services between 1989 and 2005/06 was in the area of access to information, with 40% more of the respondents providing access to commercial online services, 100% more providing access to Internet resources, and 28% more providing training in database searching and use of information resou... |
CONCLUSIONS |
Survey data support reported trends of consolidation of hospitals and hospital libraries and additions of new services. These services have likely required librarians to acquire new skills. It is hoped that future surveys will be undertaken to continue to study these trends.Multi-representation approach to text regress... |
Different approaches for textual feature extraction have been proposed starting with simple word count features and continuing with deeper representations capturing distributional semantics. In recent publications word embedding methods have been successfully used as a representation basis for a large number of NLP tas... |
One of the prominent principles of designing services is the matter of how abstract services should be i.e. granularity. Since service-oriented analysis and design methods lack on providing a quantitative model for service granularity level evaluation, identification of optimally granular services is the key challenge ... |
Comments Hepatitis B virus (HBV), a DNA virus that replicates through reverse transcription, encodes only 7 primary gene products: the capsid-forming core protein and the precore precursor of hepatitis B e antigen (HBeAg), the reverse transcriptase (P protein), 3 envelope proteins (col-lectively known as hepatitis B su... |
In this letter we introduce a novel change detection approach called ChangeGAN for coarsely registered point clouds in complex street-level urban environment. Our generative adversarial network-like (GAN) architecture compounds Siamese-style feature extraction, U-net-like use of multiscale features, and Spatial Trans-f... |
A method has been constructed for the threshold semi-adaptive scaling transformation. The method provides calculation of recurrent plots, which adequately map the dynamics of real complex dynamic systems in natural and technical spheres. A new scientific result implies the development of theoretical basis for the metho... |
This paper puts forward an evaluation index system with 20 indexes and quantitive criteria for geographical ecological environment bearing capacity based on national geographic conditions census data; the evaluation model is determined by comprehensive evaluation method and weighted by analytic hierarchy process; compr... |
This multi-method study distinguishes between four high performing and four low performing fully distributed virtual design teams, through an analysis of their asynchronous communication. Results indicate that these teams were similar in terms of the number of messages exchanged, the amount of communication devoted to ... |
Software is a vital resource for modern life. For software to be successful, programming skills are of the utmost importance. These skills are used both by programmers and also by systems analysts and designers during the phases of software development. Therefore, both technical and non-technical stakeholders within th... |
The Computer Science Department at California State University, Northridge (CSUN) has developed and is currently utilizing a process for the direct assessment of program learning outcomes that follows an approach similar to that used in the development of software. The software engineering steps have been applied in an... |
In July 2011, the European Commission released a Recommendation on access to a basic payment account. The contents of this Recommendation (where Member States are required to establish universal service obligations) imply that the Commission considers that services facilitating basic access to the financial system meet... |
Abstract Research purpose. This paper has established the index of the cycle of money. The index shows the level of the appropriately structured economy. According to the theory of the cycle of money, it is examined if an amount of money is recycled in the economy a lot of times or this amount of money is lost from an ... |
The COVID-19 pandemic and the preventive measures that followed it have significantly impacted generation and consumption patterns in power systems across the globe, calling for new tools to efficiently evaluate generation and load profiles. In this work, we propose one possible tool, which we name the smoothness index... |
Fragile X syndrome is caused by the absence of protein FMRP, the function of which is still poorly understood. Previous studies have suggested that FMRP may be involved in various aspects of mRNA metabolism, including transport, stability and/or translatability. FMRP was shown to interact with a subset of brain mRNAs a... |
The Tower of London is best known as a prison where human inmates were subjected to harsh and cruel punishments so it might be surprising that this forbidding venue also served as a repository for wild animals. The Royal Collection of Wild and Ferocious Beasts kept at the Tower of London Menagerie spanned ca. 600 years... |
Addition of glass fibers into concrete significantly modifies its tensile strength. The fibers are placed at desired locations and orientations by the matrix surrounding it, thereby making the fibers as principal load carrying members and also protecting them from environmental damage. Glass fibers provide resistance t... |
We studied five strains of a new Nocardia taxon recently identified among Nocardia brasiliensis strains associated with invasive diseases (R. J. Wallace, Jr., B. A. Brown, Z. Blacklock, R. Ulrich, K. Jost, J. M. Brown, M. M. McNeil, G. Onyi, V. A. Steingrube, and J. Gibson, J. Clin. Microbiol. 33:1528-1533, 1995) to de... |
BACKGROUND/PURPOSE |
Patients and rats with congenital diaphragmatic hernia (CDH) have lung and heart hypoplasia. Prenatal steroids improve lung hypoplasia in CDH rats. The current study tests the hypothesis that prenatal dexamethasone could rescue heart hypoplasia in rats with CDH. |
METHODS |
Timed pregnant rats received intragastrically either 100 mg nitrofen or oil on day 9.5, and other animals had the same treatment with, in addition, either 0.25 mg/kg dexamethasone intraperitoneally or no treatment on days 19 and 20. Fetuses were recovered on day 21, and heart weight to body weight ratios, heart DNA, pr... |
RESULTS |
Wet heart weight to body weight, left-to-right ventricular diameter, and aortic-to-pulmonary root diameter ratios, which were lower in fetuses exposed only to nitrofen than in their oil controls, were similar in those exposed to nitrofen plus dexamethasone than in their corresponding oil plus dexamethasone controls. To... |
CONCLUSIONS |
Heart hypoplasia in rats with CDH is in part rescued by prenatal dexamethasone treatment as expressed by increased number of smaller myocytes with higher glycogen content. Prenatal steroids could modify heart involvement in human fetuses with CDH as well.Primary care providers perform more neurologic visits than neurol... |
RATIONALE, AIMS AND OBJECTIVES |
Little is known about which medical providers, other than neurologists, are involved in the care of neurologic conditions. We aimed to describe the current distribution of outpatient neurologic care by provider type. |
METHODS |
We conducted a restrospective, cross-sectional analysis using a 20% national sample claims database that contains information on medical care utilizations from adult Fee-for-Service Medicare beneficiaries in 2015. We identified patient visits for evaluation and management services for common neurologic conditions and b... |
RESULTS |
40% of neurologic visits were performed by primary care providers (PCPs) and 17.5% by neurologists. The most common neurologic conditions were back pain (49.3%), sleep disorders (8.0%), chronic pain/abnormality of gait (6.4%), peripheral neuropathy (5.9%), and stroke (5.5%). Neurologists cared for a large proportion of... |
CONCLUSIONS |
PCPs perform more neurologic visits than neurologists. With the anticipated increased demand for neurologic care, strategies to optimize neurologic care delivery could consider expanding access to neurologists as well as supporting PCP care for neurologic conditions.Prescription Drug Abuse Among Ecstasy Users in Miami |
Abstract This study examines the nature, extent and consequences of prescription drug abuse among 143 ecstasy users in Miami. Participants were recruited through nightclub and college campus outreach, and through respondent referrals. Instrumentation included the Risk Behavior Assessment, Substance Abuse Module and Cen... |
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