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SEARCH STRATEGY |
We searched the Cochrane Neuromuscular Disease Group register (searched June 2002), MEDLINE (searched January 1966 to May 2002), EMBASE (searched January 1980 to May 2002)and CINAHL(searched January 1982 to May 2002). |
SELECTION CRITERIA |
We included randomized or quasi-randomized studies of participants with carpal tunnel syndrome treated with local corticosteroid injection. The primary outcome measure was clinical improvement. |
DATA COLLECTION AND ANALYSIS |
Three reviewers independently selected the trials to be included rated for their overall quality. Relative risks and 95% confidence intervals were calculated for each trial and summary relative risks and 95% confidence intervals were also calculated. |
MAIN RESULTS |
We identified nine randomized controlled trials. Four were excluded. One trial demonstrated clinical improvement of carpal tunnel syndrome at one month following local corticosteroid compared to placebo injection (Relative risk 3.83 (95% confidence intervals 1.82 to 8.05)). One trial compared local corticosteroid injec... |
REVIEWER'S CONCLUSIONS |
Local corticosteroid injection for carpal tunnel syndrome provides greater clinical improvement in symptoms one month after injection compared to placebo. Symptom relief beyond one month compared to placebo has not been demonstrated. Local corticosteroid injection provides significantly greater clinical improvement com... |
We revisit the minimum-variance theory proposed by Harris and Wolpert (1998 Nature 394 780–4), discuss the implications of the theory on modelling the firing patterns of single neurons and analytically find the optimal control signals, trajectories and velocities. Under the rate coding assumption, input control signals... |
With the further development of computer network technology, cloud computing technology has gradually become popular, affecting all aspects of people's lives. Some advantages of cloud computing can well make up for the shortcomings and deficiencies of existing teaching methods in the current college English teaching, o... |
Although estrogen receptor beta (ERβ) has been implicated in prostate cancer (PCa) progression, its potential role in health disparity of PCa remains elusive. The objective of this study was to examine serum estrogens and prostate tumor ERβ expression and examine their correlation with clinical and pathological paramet... |
BACKGROUND |
5α-Reductase (5AR), an NADPH dependent enzyme, is expressed in most of the prostate epithelial cells. By converting testosterone (T) into more potent androgen dihydrotestosterone (DHT), it plays an important role in men physiology and represents an efficient therapeutic target for androgen-dependent diseases. Over the ... |
METHODS |
In the present study, 2D and 3D QSAR pharmacophore models have been generated for 5ARI based on known IC50 values with extensive validations. The four featured 2D pharmacophore based PLS model correlated the topological interactions (SsOHE-index); semi empirical (Quadrupole2) and physicochemical descriptors (Mol. Wt, B... |
RESULTS |
Several important hydrophobic and hydrogen bond interactions with 5AR lead to the identification of active binding sites of 4AT0 protein in the docked complex, which include the gatekeeper residues ALA 63A (Chain A: ALA63), THR 60 A (Chain A: THR60), and ARG 456 A (Chain A: ARG456), at the hinge region. |
CONCLUSION |
Overall, this study suggests that the proposed compounds have the potential as effective inhibitors for 5AR.Effectiveness of community-based treatment for problem gambling: a quasi-experimental evaluation of cognitive-behavioral vs. twelve-step therapy. |
With the increasing availability of gambling throughout North America, there is interest in developing more effective treatments. This study compares the effectiveness of two brief outpatient treatments for problem gambling: eight sessions of Cognitive-Behavioral Therapy (n = 65) and eight sessions of a twelve-step tre... |
One of the significant developments of recent years in American life is the birth, or re-birth, of interest in ethnicity. Although the melting pot model of ethnic relations never really implied the disappearance of all traces of ethnic identity, the interests of ethnicity were expected to remain subordinated to those o... |
Rheumatoid arthritis (RA) is a chronic inflammatory disease with symmetrical polyarthritis as the major feature. Persistent inflammation leads to largely irreversible joint damage which can be seen radiographically. Radiographs depict the progression of joint damage and alterations, which are one of the major parameter... |
This paper presents a site-specific empirical channel model for large-scale propagation in a 2.4GHz outdoor wireless network. The received signal strength measurements are taken in the Higher Colleges of Technology, Ruwais campus. Ruwais is a self-contained housing complex in remote desert about 240Km from the Abu Dhab... |
This paper establishes a law-of-the-iterated-logarithm LIL version of the fundamental queueing formula L = λW: Under regularity conditions, the continuous-time arrival counting process and queue-length process jointly obey an LIL when the discrete-time sequence of interarrival times and waiting times jointly obey an LI... |
Purpose: To assess the geographical distribution of ophthalmologists in Japan before and after the start of a new postgraduate training program, which was suggested to exacerbate the uneven distribution of physicians. Methods: The number of physician per million population was calculated for ophthalmologists by using a... |
User mobility together with an easy access to distributed resources is one of the greatest challenge to be faced in the future years. At the same time, agent technology is seen as a very promising approach to deal with distributed computing and user mobility. In this paper an agent-based strategy for support of mobile ... |
Abstract In this paper the problem of optimization design of a microwave wearable antenna is investigated. Reference is made to a specific antenna design that is a wideband Vee antenna the geometry of which is characterized by 6 parameters. These parameters were automatically adjusted with an evolution strategy based a... |
. A promising direction for the development of precision seeding drills is their electrification with the development of a control system for the rotation of the disc of the seeding apparatus, as well as the improvement of the seeding control system with the subsequent development of an algorithm for automatic control ... |
> You wouldn't wear just any pair of glasses—your prescription is tailored to your vision. |
This statement was made by President Obama in 2016 during the presentation and launch of the Precision Medicine Initiative. Whether we like it or not (and some politicians today seem rather indifferent), we are headed toward a new paradigm of precision medicine. This is a new era of medicine in which the right treatmen... |
In the context of heart failure (HF)5 there is a long road ahead to fully realize the goals of precision medicine. HF is a complex syndrome with heterogeneous pathophysiology. Most medical treatments currently used in HF have been tested in large randomized clinical trials (RCTs) for the “average” patient. That is, a p... |
The Prospective comparison of angiotensin receptor-neprilysin inhibitor (ARNI) with angiotensin-converting-enzyme inhibitor (ACEI) to Determine Impact on Global Mortality and morbidity in Heart Failure (PARADIGM-HF) trial, published in 2014, may …Computational Study of the Reaction of Dimethyl Ether with Nitric Oxide. ... |
To probe into the autoignition effect of nitric oxide (NO) on the combustion of dimethyl ether (DME), a detailed mechanism study and kinetic modeling for the reaction of DME with NO, which was considered to be very sensitive to the ignition delay time of DME, have been conducted using computational chemical methods. Th... |
Access to neuropathology is now becoming more and more difficult for clinical neurologists in Japan mainly because the numbers of autopsies and neuropathology laboratories to evaluate the brain are in catastrophic decline. This decline does not mean neuropathology is not necessary any more for neurology. Rather, neurop... |
Abstract Karyological study was conducted on 9 populations of Melilotus officinalis (L.) Pall. collected from different floristic regions in Bulgaria. The karyotypes of the investigated populations are similar in their chromosomal morphology consisting of metacentric and submetacentric chromosomes. Three cytotypes are ... |
Shape Distribution (SD) describes the global feature of 3D CAD model which can be used to distinguish one model from others. But sometimes, different models may have the similar SD features. In this case SD is not suitable for 3D CAD model retrieval. Although two models have the same SD features, their oriented boundin... |
We present a novel method for robotic mower's lawn obstacle avoidance as well as motion control, which is based on the Gabor texture classification and drivable region search methods. In our approach, a camera is applied to obtain real-time image streams of lawn scenes, Gabor filters are then applied for extracting rob... |
Populus is an important model organism in forest biology, but levels of nucleotide polymorphisms and linkage disequilibrium have never been investigated in natural populations. Here I present a study on levels of nucleotide polymorphism, haplotype structure, and population subdivision in five nuclear genes in the Europ... |
Tobacco-related disease kills 178 000 women each year in the United States,1 yet a search for the public discourse on this fact reveals a profound silence. As a nation, we have failed to mount and support an organized public response to the ongoing public health tragedy of tobacco use. The public health community must ... |
Although many of us are activists and many are working to counteract tobacco’s harm, the public remains largely silent, its lack of outrage evident in the daily news, in the public debate on smoking bans, and in the lack of pressure on our government to protect workers, families, and children. There is so little public... |
How can we as public health practitioners change this silence into a public demand for comprehensive tobacco control that includes prevention, cessation, and regulation? How can we join together to give voice to the women and men who die each year in America of tobacco-related diseases? How can we prevent the needless ... |
A handheld Raman detector with operational convenience, high portability, and rapid acquisition rate has been applied in clinics for diagnostic purposes. However, the inherent weakness of Raman scattering and strong scattering of the turbid tissue restricts its utilization to superficial locations. To extend the applic... |
Recent studies suggest that angiotensin II (Ang II) plays a role in the adipogenesis of murine preadipocytes. Here, we examined the role of Ang II for the differentiation of primary cultured human preadipocytes. Preadipocytes were isolated from human adipose tissue and stimulated to differentiate. Quantitation of gene ... |
The author reviewed K. Yu. Rakhno’s monograph «Bat’s Cry: Pottery Craft in the Folklore Heritage of the Ukrainians». The complex nature of the research and the interdisciplinary approach in covering the announced topic are emphasized. It is noted that the author of the monograph builds a holistic concept of the develop... |
Günther Anders was a philosopher concerned with the political and social implications of power, both as expressed in the media and its tendency to elide the citizenry and thus the very possibility of democracy and the political implications of our participation in our own subjugation in the image of modern social media... |
*National Institute of Economic and Social Research. E-mail: j.portes@niesr.ac.uk. Over the next few years, the issue of the UK’s membership of the European Union is likely to be at the centre of our political debate. The main parties recognise that a referendum on membership may be desirable and possibly even necessar... |
This paper is the result of an international initiative and is a first attempt to develop guidelines for the care and welfare of cephalopods (i.e. nautilus, cuttlefish, squid and octopus) following the inclusion of this Class of ∼700 known living invertebrate species in Directive 2010/63/EU. It aims to provide informat... |
Liquid cooling systems are effective for keeping the battery modules in the safe temperature range. This study focuses on decreasing the power consumption of the pump without compromising the cooling performance. Artificial neural network (ANN) models are created to predict the effects of the height and width of the co... |
Scanning electron micrographs of sheep erythrocytes showed that attachment of the alpha hemolysin produced by Escherichia coli resulted in the formation of spherocytes, with 10 to 20 small projections spaced relatively evenly over the surface of the erythrocyte membrane. This shape change was induced within 5 min after... |
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