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Autophagy is an evolutionarily-conserved catabolic process which furthers cell survival, especially in times of nutritional stress. Whilst being by itself a pro-survival mechanism, it has many areas of overlap with apoptosis. Autophagic cell death is recognised as a subset of programmed cell death, with features more t... |
This study attempts to explain a process of inserting global transnational elements into an undergraduate sociology course. After a review of global themes covered in introductory sociology textbooks, the author administered two projects (Global Multiculturalism and Sociology of Wal-Mart) in an undergraduate sociology ... |
In this paper, we investigate the effects of goodwill accounting under IAS 36 on dividend policy in Italian Listed Companies. The technical areas of discretion in impairment test accounting enable pursuing three typical forms of earnings management: earnings smoothing, earnings increasing and earnings decreasing. Possi... |
An Events Data Recorder (EDR) is a unit that record movement parameter of a vehicle mainly used for accident analyzes purposes. Many of EDR has designed for automobile, however they have to be physically connected to sensors integrated with the car's engine and system. That is why it is not easy deploy and very high co... |
The authors propose some syntactic and semantic extensions to a graphical specification called the signal transition graph (STG). They allow controlled-choice places to have fanout transitions of input signals and arbitrary Boolean expressions can be used as edge labels. They also allow one STG marking to represent mor... |
Undergraduate medical education has undergone a revolution in the last decade. This has been stimulated by the realisation that the current system is unsustainable and may produce doctors who are ill-fitted to practice medicine at the end of the 20th and beginning of 21st centuries. Some of the new ideas have had their... |
Identifying important assets and evaluating the risk they pose to cyber-physical power systems, when compromised, is critical to maintaining the system security and resilience. The cyber-physical betweenness centrality (CPBC) index presents a suitable means for enhancing system resilience through vulnerability analysis... |
The shortage of blood components is a problem on a global scale. Allied to this issue, there is no substance that can, in its totality, substitute the blood tissue. Because of its perishable characteristic and, considering that it comes from voluntary donation in most of the countries, bringing a big load of uncertaint... |
This study describes and interprets midwives' and public health nurses' perceptions of their experiences of caring for young women during pregnancy and early motherhood. A number of studies suggest that teenage pregnancy is associated with many adverse psychological, physical, social, and financial outcomes. Multistage... |
The too close for comfort that we provide for you will be ultimate to give preference. This reading book is your chosen book to accompany you when in your free time, in your lonely. This kind of book can help you to heal the lonely and get or add the inspirations to be more inoperative. Yeah, book as the widow of the w... |
Working out Egypt blends class-conscious social history with cutting edge reconceptualizations of biopolitical sovereignty and gender performativity – and it does so while avoiding the persistent Eurocentrism of many of the scholars influenced by Foucault and Agamben and shattering the frames of cultural relativism tha... |
OBJECTIVE |
To investigate gene expression of the major proteolytic systems and growth regulators in skeletal muscle of horses with myopathy associated with pituitary pars intermedia dysfunction (PPID). |
ANIMALS |
14 horses with PPID-associated myopathy and 7 healthy control horses. |
PROCEDURES |
Horses with PPID and controls were age matched (15 to 28 years old). Muscle biopsy specimens were collected from both groups and processed for RNA and cDNA extraction. Validation of the most stable housekeeping genes for skeletal muscle was performed and used to compare gene expression of the following proteolytic syst... |
RESULTS |
No significant difference between groups was detected in expression of the major proteolytic systems except for m-calpain, which was greater in horses with PPID. No differences in gene expression of myostatin and interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha were detected between groups. |
CONCLUSIONS AND CLINICAL RELEVANCE |
Greater expression of m-calpain may suggest that calpains play an important role in development of muscle atrophy in horses with PPID. However, because posttranslational events may alter protein activation, inactivation, and functions not studied here, other mechanisms of muscle atrophy cannot be excluded.Single‐bolus ... |
Abstract Currently, most centers use antithymocyte globulin (ATG) for induction or treatment of acute rejection. In the literature, postponement of introduction of cyclosporin or delay in acute rejection following ATG induction are well documented [1‐4]. In contrast, data are very scant on the reduction of incidence of... |
The urbanization process all over the world has caused serious ecological and environmental problems which have recently become a focus for study. Ecological footprint analysis, which is widely used to assess the sustainability of regional development, can quantitatively measure the human occupation of natural capital.... |
Decreased levels of docosahexaenoic acid (DHA), an endogenous neuroprotective compound, in the brain are associated with the development of Alzheimer’s disease (AD). We previously showed that DHA is a substrate of fatty acid transport protein 1 (FATP1/SLC27A1), and FATP1 is localized at the abluminal membrane of brain ... |
The ETn (for "early transposon") family of long repeated sequences in abundantly transcribed in early mouse embryos from retroviral-like long terminal repeats. Nucleotide sequencing of two elements does not reveal any long open reading frame nor significant homology to retroviral proteins. The genetic polymorphism, mon... |
Energy security is currently one of the key components of national security of any country. The object of this research is the basic documents of strategic planning of the European Union in sphere of ensuring energy security (Roadmap of the European Union “Final 10-year ETIP SNET R&I roadmap covering 2017-26”) in the ... |
Expression of islet amyloid polypeptide in fetal and adult porcine and human pancreatic islet cells. |
The synthesis and intracellular localization of the putative hormone islet amyloid polypeptide (IAPP) and its relation to insulin and glucagon during ontogenesis was investigated in fetal and adult porcine and human pancreatic islets. By means of ultrastructural immunogold immunocytochemistry, it was revealed that IAPP... |
Despite the dearth of research on Estonian attitudes towards Jews we know that there was no large-scale violent anti-Semitism in Estonia in the interwar period. On the contrary, in 1925 the Estonian government passed a Law of Cultural Autonomy of the Minorities, which was extraordinary, perhaps even unique, from an int... |
A 52-year-old woman with cutaneous T-cell lymphoma (CTCL) presented to the dermatology clinic for treatment. She had a more than 10-year history of episodic dry, itchy patches over her trunk and extremities. Previous biopsy specimens obtained from the patches revealed histopathologic changes typical of CTCL. Treatment ... |
This study builds on the results of the University of Pennsylvania sponsored phase I study of a single peripheral infusion of chimeric antigen receptor (CAR) T cells targeting epidermal growth factor receptor variant III (EGFRvIII) in recurrent glioblastoma (GBM) (NCT02209376). A dose of 5x108 CART-EGFRvIII cells was ... |
This single-center study (NCT03726515) has a single-arm, open-label, phase 1 design and will enroll 7 patients with newly diagnosed, O6-methylguanine-methyltransferase (MGMT)-unmethylated, EGFRvIII+ GBM. Following maximal safe tumor resection, patients receive a short course of adjuvant radiation with a total dose of ... |
Future Proofing Your Department |
Many forces are impacting the academic landscape such as increasing competition, the inability of American families to pay for college, and the growth of for-profit universities. Accountability to external stakeholders also remains at the forefront of this discourse. Through the lens of upper administration, this paper... |
The whole body retention, distribution, and metabolism of carboxyl-14C-labeled 2,3,5-triiodobenzoic acid (TIBA*) were studied in five laying hens. A single oral dose of TIBA* showed a 22-hr, biological half-life. No organ concentration of TIBA* was noted. TIBA* and seven labeled metabolites were found in excreta collec... |
In this article, we introduce a potential game-based approach to implement collaborative user scheduling and power allocation in the uplink multibeam satellite-based Internet of things (S-IoT) networks. First of all, a framework of the multibeam uplink S-IoT system is proposed, where full frequency reuse and co-channel... |
Objective To determine the prevalence and pattern of various medical conditions in pregnancy and also determine their impact on fetal and maternal outcome. Study Design A cross-sectional analytic study was conducted using labor ward data obtained over a period of 5 years (2013–2017). All women delivered at Lagos Univer... |
We use a state-of-the-art ocean general circulation and biogeochemistry model to examine the impact of changes in ocean circulation and biogeochemistry in governing the change in ocean carbon-13 and atmospheric CO 2 at the last glacial maximum (LGM). We examine 5 different realisations of the ocean’s overturning circul... |
Approaches to knowledge management have included the classification of knowledge along different dimensions. Such classifications are useful in acknowledging the varied nature of what we understand as ‘knowledge’. In this paper, we seek to explore additional dimensions along which knowledge can be described, inspired b... |
This paper deals with a class of uncertain linear dynamic systems. The class of systems under consideration is described by a continuous-time uncertain model with multiple time-varying delays in both states and controls. The uncertainties are unknown but satisfy the rank-one conditions. It is shown that the constructio... |
Results are presented on a comparison of nutritional values of and human psychological responses to algae and of higher plants considered for growth as food on long-term missions in space, together with the technological complexities of growing these plants. The comparison shows the advantages of higher plants, with re... |
The enzymatic hydrolysis parameters of triacylglycerols (TAGs) in algae oil to get sn-2 glycerel monostearte including substrate amount, lipase amount and reaction time was studied, and the products of fatty acid methyl esters (FAMEs) were detected by gas chromatography (GC). The result indicated that the optimum condi... |
OBJECTIVE |
Variceal bleeding in cirrhosis is mainly due to platelet activation defect and secondary to coagulation defects. Secretion is an important process which release procoagulants for hemostasis. In the present investigation we have evaluated the secretory function of platelets in liver cirrhosis and also the simultaneous c... |
METHODS |
Liver cirrhotic patients with (n=27) or without (n=23) bleeding complication were included in the study. Control subjects (n=50) were also utilized for the study to compare the analytical data. Platelets were activated by collagen in vitro and the secretory response was assessed by the levels of nucleotides, serotonin,... |
RESULTS |
The secretory response of platelets to collagen was significantly low in both bleeders and non-bleeders when compared to that of normal subjects. During secretion, low level of actin polymerization and cytosolic Ca2+ level were observed in the platelets of bleeders than in non-bleeders and normal subjects. The low secr... |
CONCLUSION |
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