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METHODS |
The compounds in SQSRP were obtained from public databases and related literature, and oral bioavailability (≥30%) and drug-likeness (≥0.18) were screened using absorption, distribution, metabolism, and excretion (ADME) criteria. Compounds-related and CSM-related target genes were identified using public databases, and... |
RESULTS |
A total of 447 compounds in SQSRP were identified, and ADME screening identified 96 compounds as potentially active ingredients. A total of 249 compound-related genes and 280 CSMrelated genes were identified using public databases, and 53 overlapping genes were identified. The results of compound targets and protein-pr... |
CONCLUSIONS |
The active ingredients and mechanisms of SQSRP against CSM were investigated using network pharmacology. The findings proved that the pill could treat CSM through multi-component, multitarget, and multi-pathway synergy and provide a theoretical basis for the subsequent extraction of active ingredients from SQSRP.Recent... |
The high fuel efficiency of natural gas makes it an attractive alternative to coal and oil during the transition towards renewable energy resources. Natural gas engines are needed to ensure a stable power grid that can accommodate fluctuations in renewable energy production. Unfortunately, these engines emit as much as... |
The traditional tools used to treat the slopes stability problem are based on simple static approaches like calculation in limit equilibrium by the slices method. These approaches, though practicable, are not rigorous as they don’t take into account the seismic action on the structures. Recent progresses made in data c... |
Abstract Background: Bacterial infections are common complications in kidney transplant recipients (KTRs). Little is known about incidence rates of bacteremia and fungemia (BAF) in KTRs. Methods: In this population-based cohort study, we used medical and administrative registries to identify episodes of BAF among KTRs ... |
Abstract Objectives: This study investigated the association between myositis-specific autoantibodies (MSAs) and clinical subsets of juvenile dermatomyositis (JDM) in Japanese patients. Methods: Twenty-one patients at a single center who developed initial or relapsed JDM from 2011 to 2016 were analyzed. Serum concentra... |
The concept of so called Thought Bubbles deals with the problem of finding appropriate new connections within Social Networks, especially Twitter. As a byproduct of exploring new users, Tweets are classified and rated and are used to generate a kind of news feed, which will extend the personal Twitter feed. Each user h... |
ABSTRACT The staphylococcal pentaglycine side chain of the peptidoglycan is reduced to one glycine in femAB null mutants. This is associated with increased susceptibility to methicillin and to a whole range of unrelated antibiotics as well. Genetic evidence suggests thatfemAB null mutants are only viable because of a c... |
Driver functions for the Earth's magnetosphere‐ionosphere system are derived from physical principles. Two processes act simultaneously: a reconnection‐coupled MHD generator 𝒢 and a viscous interaction. 𝒢 accounts for the dayside reconnection rate, the length of the reconnection X line, and current saturation limits ... |
In globalization process of communication and media market transformations context, we focus our research on some peculiar features of journalism in three islands : Reunion Island, Mauritius Island, and Malagasy. We study journalists’ professional practices and their transformations when daily newspapers are electronic... |
This paper aims to explore South African Life Orientation teachers' perception and practice of teaching HIV/AIDS and sexuality in a cultural perspective. We aim to investigate how teachers respond to perceived cultural differences between the local community and the content of their teaching. Data were collected throug... |
BACKGROUND |
It was shown earlier that a number of CD207 positive Langerhans cells was lower in basal cell carcinomas than in the normal epidermis. Moreover, benign skin lesions presented a higher number of Langerhans cells when they were compared to malignant tumors. |
AIM |
To count Langerhans cells, assessing expression levels of CD1A and CD207 markers in actinic keratosis, basal and squamous cell carcinomas, compared with the normal skin. Comparison of Langerhans cells might give a valuable prognostic marker for skin cancer. |
METHODS |
Immunohistochemistry and methods of statistics were used. |
RESULTS |
Expression of CD1A and CD207 markers was assessed in tumor samples of actinic keratosis, cutaneous basal and squamous cell carcinomas, in comparison with the normal skin. In each cohort there were 40 patients (and 11 healthy individuals). We have shown that the number of Langerhans cells is considerably lower in cutane... |
CONCLUSIONS |
CD1A expression correlated with CD207 expression only in the control group. There was no correlation in actinic keratosis, basal and squamous cell carcinoma. This may suggest an alteration of Langerhans cells phenotype in skin neoplastic diseases, making the number of Langerhans cells a valuable prognostic factor for s... |
Objective The objective of this paper is to identify predictors for the response to treatment of acute lupus hemophagocytic syndrome (ALHS). Methods We reviewed seven cases with ALHS admitted to our hospital and published ALHS cases identified in the 2001–2014 Medline database, and then conducted univariate and multiva... |
increasing the sorption capacity of medications based on interleukin-12 and interleukin-23 in patients with psoriatic arthritisTo reduce the concentration of anti-inflammatory cytokines (IL-12, IL-23) we ran the blood from psoriatic arthritis patients through granules which had been obtained preliminarily by emulsion p... |
This paper evaluates the effectiveness of information-theoretic anomaly detection algorithms applied to networks included in modern vehicles. In particular, we focus on providing an experimental evaluation of anomaly detectors based on entropy. Attacks to in-vehicle networks were simulated by injecting different classe... |
The Internet of Things (IoT) represents a diverse technology and usage with unprecedented business opportunities and risks. The Internet of Things is changing the dynamics of security industry & reshaping it. It allows data to be transferred seamlessly among physical devices to the Internet. The growth of number of int... |
The supply chain agility concept has been identified as one of the most important issues in the supply chain management literature. However, despite the popularity of the concept, many concept attributes are largely unexplored. The mediating role of the operational capabilities, in particular the supply chain responsiv... |
: Cloud computing is quickly becoming a dominant model for end-users to access centrally managed computational resources. Through our work in extending OpenStack, we have demonstrated the feasibility of providing technical computing users with access to heterogeneous computing resources using a cloud computing model.th... |
Objective: To investigate the outcomes of knee dislocations treated with primary repair and an early rehabilitation protocol. Design: Retrospective. Settings: Level 1 Trauma Center. Patients: Consecutive patients with knee dislocation referred to a single surgeon for care between 1994 and 2002 were included, for a tota... |
Home-prepared diets for dogs On behalf of Just Food For Dogs LLC, I would like to express concerns with the recent study by Stockman et al regarding their evaluation of the nutritional adequacy of a large number of recipes for homeprepared maintenance diets for dogs. Many dog owners, for a wide variety of reasons, have... |
Marginal difference, huge impact: The topological analyses of the electron-density distributions obtained from experiment (see figure) and quantum-chemical calculations in the two title compounds can consistently explain marginal changes in bonding and rationalize different catalytic abilities. The electronic structure... |
The Arabidopsis pseudo-response regulator, APRR1, has a unique structural design containing a pseudo-receiver domain and a C-terminal CONSTANS motif. This protein was originally characterized as a presumed component of the His-to-Asp phosphorelay systems in Arabidopsis thaliana. Recently, it was reported that APRR1 is ... |
Abstract Thigpen, LK, Green, JM, and O'Neal, EK. Hydration profile and sweat loss perception of male and female division II basketball players during practice. J Strength Cond Res 28(12): 3425–3431, 2014—Hydration affects multiple aspects of basketball performance, but few investigations have examined the hydration pro... |
Introduction/Background In Japan, the number of BRCA testing is increasing annually. But, till recently, genetic counselling for epithelial ovarian cancer (EOC) has not been generalized. We investigated the awareness survey and the rate of HRD mutation included gBRCA1/2 mutation with EOC, regardless of their family his... |
Studies on reduction of chemical oxygen demand (COD) in effluent from sugar industry have been carried out by employing different absorbents optimizing various parameters, such as initial concentration of adsorbate, pH, adsorbent dosage and contact time. Experimental studies were carried out in batches using metakaolin... |
New solutions of the Boussinesq equations describe the onset of convection as well as the development of collimated bipolar jets near a point source of both heat and gravity. Stability, bifurcation, and asymptotic analyses of these solutions reveal details of jet formation. Convection (with l cells) evolves from the re... |
Background and Purpose The odontogenic keratocyst (OKC) is an unusual cyst with a high recurrence rate. The most common site for OKCs is by far the mandible. The best treatment of OKC remains controversial. Recurrence rates ranging anywhere from less than 10% to more than 60% have been reported. The aim of our study wa... |
Since the mid-1990s, media organizations all over the world have experienced a series of significant changes related to technological developments, from the organizational level down to the single journalist. Ownership in the media sector has developed toward increased concentration, mergers, and cross-media ownership.... |
We have developed a conceptual framework that can be used as customer perception based organization performance measurement framework for healthcare service. The conceptual framework consists of customer satisfaction, perceived sacrifice, and perceived service quality. This paper aims to validate the conceptual framewo... |
Diffusion‐weighted (DW‐) MRS investigates non‐invasively microstructural properties of tissue by probing metabolite diffusion in vivo. Despite the growing interest in DW‐MRS for clinical applications, little has been published on the reproducibility of this technique. In this study, we explored the optimization of a si... |
The author substantiates the role and importance of music in encouraging child’s speech and language development. The purpose of this article is to determine the effect of music presence in learning process, analyse the changes in speech development of elementary school students through musical interaction and justify ... |
Keywords: language development; music art; music computer technologies; speech development; speech skills; logarithmics; psychogymnastics; dance-rhythmic exercises; elementary school students; speech production system.Review of physical therapy alternatives for reducing muscle contracture. |
Passive stretching is a technique frequently used to treat muscle contractures; however, because it can activate the stretch reflex and has little carry-over, it may not be as effective as other modes. Four approaches to treating muscle contracture are described: 1) activation or strengthening of the weak oppnent, 2) l... |
An innovative vibration-compensation method, with phase-modulating interference fringe subdivision technology, is described. It simulates fringe movement by the phase difference of signals and can detect the fringe movement with an accuracy of 1/400 fringe spacing using this subdivision technology. A closed-loop vibrat... |
Aims |
Early maladaptive schemas described by Young theoretically underlie the development of psychopathology, including substance use. The key assumption is that the schemas do not act in isolation but create configurations that are, at least to a certain extent, distinctive for specific disorders. Thus, the aim of the curre... |
Short Summary |
Early maladaptive schemas are cognitive and behavioral patterns related to a wide spectrum of psychopathology, including alcohol addiction. However, the assumption that the configuration of schemas varies across disorders still needs verification. In the sample of alcohol-addicted people, only heterogeneity was noted, ... |
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