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There is room for improvement in the management of DFI at this institution. A specific area that has been identified is the overuse of empiric anti-pseudomonal agents in patients without risk factors for P. aeruginosa. The results of this study will be evaluated alongside consensus guidelines and used to create instit... |
All Authors: No reported disclosures |
Is the 52-week high momentum strategy profitable outside the US? |
This paper uses Australian stock data to provide the first out-of-sample test of the 52-week high momentum strategy. The robustness of price and industry momentum strategies is also considered. We find the 52-week high momentum strategy is highly profitable on Australian stocks that have been approved for short-selling... |
In the flip-chip mounting of MMIC chips, an adequate separation between the flip chip and the mounting substrate must be maintained to prevent undesirable loading effects. In this paper, as an approach to solve this restriction, an electrically shielded MMIC is presented. This can be realized employing multilayer MMIC ... |
Notch signals drive pathogenic T cell alloreactivity in mouse models of allogeneic bone marrow transplantation (allo-BMT) leading to lethal graft-versus-host disease (GVHD). In a mouse model of MHC-mismatched allo-BMT with high intensity whole body conditioning (11 Gy), residual recipient or donor hematopoietic cells ... |
To characterize stromal sources of Notch ligands early after allo-BMT, we combined a Ccl19-Cre transgene with a ROSA26-YFP Cre-activated allele in Dll4-mCherry BAC reporter mice. We observed combined Ccl19-Cre activity and Dll4-mCherry reporter expression in CD157hi fibroblastic reticular cells, MAdCAM1+ marginal reti... |
To assess the functional impact of conditioning on the cellular sources of Notch ligands, we studied a parent-to-F1 allo-BMT model in which recipients are tolerant to donor-derived T cells, and the conditioning intensity can be titrated (C57BL/6 [H-2b] or BALB/c [H-2d] into BALB/c x C57BL/6 F1 [H-2d/b]). Cell-specific... |
Because previous studies indicated that non-hematopoietic cells can serve as antigen-presenting cells in CD4+ T cell mediated GVHD, we tested if fibroblastic stromal cells could present MHC class II alloantigens in addition to Notch ligands. We used Ccl19-Cre+ crossed to mice with a floxed I-A allele to delete the cel... |
Blazar: Kadmon Corporation, LLC: Consultancy, Research Funding. Siebel:Genentech: Employment. |
[Use of sugammadex in a patient with amyotrophic lateral sclerosis]. |
Amyotrophic lateral sclerosis (ALS) is a degenerative disease involving motor neurons. The anesthetic problem is increased susceptibility to non-depolarizing muscle relaxants and the feasibility of spinal and epidural anesthesia. An 86-year-old man with ALS underwent colostomy to the ileus. We chose general anesthesia ... |
BACKGROUND |
The performance of QuantiBRITE phycoerythrin (PE) beads to standardize quantitation in terms of antibodies bound per cell (ABC) was evaluated by measuring precision, variation across multiple instruments, and variation across time. |
METHODS |
For CD4 quantitation, whole blood was stained with a two-color CD4 reagent using a no-wash/no-lyse format. For CD69 quantitation, whole blood was activated with either phorbol myristate acetate (PMA) or CD3 beads and then stained with a three-color CD69 reagent using a lyse-no-wash format. |
RESULTS |
Across 20 normal donors, the mean CD4 ABC was 51,000. Within-assay precision on quantitation of CD4 ABC on T cells had a coefficient of variance (CV) of <1.0%. Across multiple flow cytometers, quantitation of CD4 ABC had a CV of <5.0%. Within-donor CV on CD4 ABC on 20 donors across 2 months ranged from 1.3% to 3.2%. Wi... |
CONCLUSIONS |
Our results indicate that the QuantiBRITE PE beads provide a useful tool for standardized analysis across labs. When used in conjunction with 1:1 conjugates of PE-to-monoclonal antibody, the QuantiBRITE PE beads provide a simple yet robust means of quantitating expression levels in terms of ABC.Ocular Retention and Bio... |
The present study was designed to formulate the sustained ocular delivery of bromfenac loaded mucoadhesive chitosan nanoparticles (NPs). The NPS were prepared by different ratios of chitosan and sodium alginate by ionic gelation method. The prepared nanoparticles were characterized by its particle size, zeta potential,... |
Previous studies have shown that, in general, young, postnatal animals are more sensitive than adults to the toxic effects of anticholinesterase (antiChE) pesticides. Paradoxically, often fetal brain cholinesterase (ChE) is less inhibited than maternal brain after gestational exposure to an antiChE, presumably due to p... |
A comparative analysis of 220 reconstructions of the aortofemoral segment with the application of vascular prostheses of firms "Sever" and "Vascutek" was made. It was established that in patients with obvious anemia and hemodilution (hematocrit less than 25%, hemoglobin less that 80 g/l) an important condition for less... |
Prior case–control studies reported that levels of the soluble form of the endothelial protein C receptor (sEPCR) were strongly controlled by the PROCR 6963A/G polymorphism and higher levels were a risk factor for venous thromboembolism (VTE). We sought to prospectively examine the association of sEPCR and the 6963A/G ... |
Age-related impairments during spatial navigation have been widely reported in egocentric and allocentric paradigms. However, the effect of age on more specific navigational components such as the ability to drive or update directional information has not received enough attention. In this study we investigated the eff... |
The minimization and outright elimination of losses continues to dominate the agenda of manufacturers especially in capital intensive industries. Successful companies are required to report and demonstrate Continuous Improvement (CI) and communicate best practices across the entire company globally on a regular basis. ... |
ABSTRACT This qualitative study explores how employees engage in sensemaking during Organization Development (OD) initiatives in chaebols, that is, large family-owned firms in South Korea. In adopting a case study approach, semi-structured interviews were conducted with 37 respondents drawn from different levels of a c... |
Through extensive application of DNA strand displacement technology in the field of molecular computing, we know that the DNA strand of the toehold domain and the branch migration domain are covalently connected to form logical gates in traditional DNA strand displacement circuits. In this paper, we will adopt a compos... |
In this paper, we propose the concept of delegatable proofs of knowledge (DPoK). A delegatable proof of knowledge enables a prover to delegate its proving work to another party instead of doing that itself. If the prover delegates the work to any party, the delegated party can prove the prover’s statement to the verifi... |
Light-emitting diodes are ahead of traditional light sources in terms of luminous efficacy (luminous flux per unit of electrical power consumption), which arouses an increased interest in the developers of LED lamps in the standard size of incandescent lamps. When designing LED lamps for direct replacement of incandesc... |
Abstract. Fluorescence molecular tomography (FMT) is a promising tool in the study of cancer, drug discovery, and disease diagnosis, enabling noninvasive and quantitative imaging of the biodistribution of fluorophores in deep tissues via image reconstruction techniques. Conventional reconstruction methods based on the ... |
Compared with conventional tumor photothermal therapy (PTT), mild‐temperature PTT brings less damage to normal tissues, but also tumor thermoresistance, introduced by the overexpressed heat shock protein (HSP). A high dose of HSP inhibitor during mild‐temperature PTT might lead to toxic side effects. Glucose oxidase (G... |
OBJECTIVE |
To describe and evaluate a technique for radical resection of the lateral body wall for treatment of fibrosarcoma with reconstruction using polypropylene mesh and a caudal superficial epigastric axial pattern flap in cats. |
STUDY DESIGN |
Prospective, clinical study. |
ANIMALS OR SAMPLE POPULATION |
Six client-owned cats with fibrosarcoma. |
METHODS |
Six cats with histologically confirmed fibrosarcoma of the lateral body wall were staged using radiography and/or computer tomography scanning. Preoperative radiotherapy was used in 3 cats. All cats had the lateral abdominal wall resected and reconstructed with polypropylene mesh. A caudal superficial epigastric flap w... |
RESULTS |
Minor dehiscence of the skin flaps occurred in 2 cats, and 1 other cat was successfully resuscitated from respiratory and cardiac arrest after surgery. All tissue specimens were tumor-free at the surgical margins. Follow-up times ranged from 12 to 21 months, with a mean time of 17.2 months. None of the cats had evidenc... |
CONCLUSIONS AND CLINICAL RELEVANCE |
Radical lateral body-wall resection and reconstruction is an effective technique for achieving local tumor control with acceptable patient morbidity. Further studies are needed to assess whether the technique will result in improved tumor-free intervals and survival times.Centenary of William Osler's 1885 Gulstonian Le... |
One hundred years ago, in March 1885, the young William Osler (1849-1919), recently appointed Professor of Clinical Medicine at the University of Pennsylvania, delivered his three Gulstonian Lectures on 'Malignant Endocarditis' to the Royal College of Physicians. They were soon published in the British Medical Journal ... |
Infrared laser ablation sample transfer (LAST) was used to collect samples from solid surfaces for mass spectrometry under native spray conditions. Native mass spectrometry was utilized to probe the charge states and collision-induced unfolding (CIU) characteristics of bovine serum albumin (BSA), bovine hemoglobin (BHb... |
In these enzyme-linked immunosorbent assays for determination of autoantibodies (IgG, IgM) against collagen type I (ACA I), III (ACA III), and IV (ACA IV), we use commercially available antigen preparations. Inhibition curves showed limited cross-reactivity between these different collagen preparations, the major inter... |
reflects on their own intellectual companions in their various scholarly endeavours. The consequent link between memoir and memory gives the book its distinctive quality, a kind of ego-histoire that productively crosses the line between personal and professional engagement. Siobhan Kattago’s lucid introduction starts o... |
Jorgensen’s inequality gives a necessary condition for the discreteness of a non-elementary group of isometries of hyperbolic 3-space. The main idea of the proof may be generalised widely but the statement is quite specialised. Here we give a scheme for restating Jorgensen’s inequality for Mobius transformations of a m... |
Methods of compressing HDTV (high-definition television) image sequences are investigated. Best results are achieved by a new combination of median adaptive intraframe prediction and arithmetic coding of the resultant prediction error. Fully reversible compression with low computational complexity is possible. The meth... |
Abstract The Etive Formation of the Middle Jurassic Brent Group in part of the Northern North Sea comprises dominantly clean, fine- to medium-grained sands, deposited as part of a barrier-bar complex. The overlying Ness Formation was deposited on supra- or intertidal fiats, and comprises silty channel sands with silts,... |
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