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RESULTS |
The addition of telmisartan resulted in a significant reduction of albuminuria from median 157 to 67 mg/24h. No change in creatinine clearance was observed (93 vs 97 ml/min). |
CONCLUSION |
The addition of telmisartan to a maximum dose of ACEI is safe and results in further albuminuria decrease in patients with type 2 diabetes and incipient nephropathy.Structural basis of activity and allosteric control of diguanylate cyclase. |
Recent discoveries suggest that a novel second messenger, bis-(3'-->5')-cyclic di-GMP (c-diGMP), is extensively used by bacteria to control multicellular behavior. Condensation of two GTP to the dinucleotide is catalyzed by the widely distributed diguanylate cyclase (DGC or GGDEF) domain that occurs in various combinat... |
The detection of a difference between two n-dimensional vectors based on a noisy measurement of each vector is important for surveillance, quality control, motion detection, and other applications. Because of cost or complexity, an arbitrary reduction from n to p dimensions may be required before measurements are perfo... |
It is common practice to study jump landing mechanics by having subjects step off a box set at a certain height instead of landing from a jump. This practice assumes that the landing mechanics are similar between stepping off a box and a countermovement jump as long as the heights can be matched. The mechanics of the t... |
ARSTRACT. Wildfires alter the quantity and quality of allochthonous detritus in streams by burning riparian vegetation and through flushing during postfire floods. As such, fire disturbance may negatively affect detritivorous insects that consume coarse organic matter. We assessed how 2 crown fires impacted stonefly de... |
The utility model relates to an aluminum alloy fence door and a fence. An A pillar is an extrusion aluminum alloy hollow section. A spearhead is extruded on a head part of a B pillar of the extrusion aluminum alloy and integrated with the B pillar. One ends of an upper transverse rod, a middle transverse rod, a lower t... |
Availability of irrigation water of appropriate quality is becoming critical in many regions. Excess salt in irrigation water represents a risk for crop yield, crop quality, and soil properties. During the short vegetation period, field peas require high amounts of water, and irrigation is often indispensable for succe... |
OBJECTIVES |
The purpose of this study was to compare the discontinuation rates of tofacitinib and biologics (tumour necrosis factor inhibitors (TNFi), abatacept, rituximab, and tocilizumab) in rheumatoid arthritis (RA) patients considering inadequate responses (IRs) to previous treatment(s). |
METHODS |
Randomised controlled trials of tofacitinib and biologics - reporting at least one total discontinuation, discontinuation due to lack of efficacy (LOE), and discontinuation due to adverse events (AEs) - were identified through systematic review. The analyses were conducted for patients with IRs to conventional syntheti... |
RESULTS |
The analyses of 34 studies showed no significant differences in discontinuation rates between tofacitinib and biologics in the cDMARDs-IR group. In the biologics-IR group, however, TNFi (RR 0.17, 95% CrI 0.01-3.61, P[RR<1] 92.0%) and rituximab (RR 0.20, 95% CrI 0.01-2.91, P[RR<1] 92.3%) showed significantly lower total... |
CONCLUSIONS |
The comparability of discontinuation rate between tofacitinib and biologics was different based on previous treatments and discontinuation reasons: LOE, AEs, and total (due to other reasons). Therefore, those factors need to be considered to decide the optimal treatment strategy.Description of a Turbulent Cascade by a ... |
Fully developed turbulence is still regarded to be one of the main unsolved problems of classical physics. Great efforts have been made towards an understanding of small scale turbulent velocity fluctuations, which are assumed to be stationary, homogeneous, and isotropic in a statistical sense [1]. For large Reynolds n... |
An ultra-low power neural spike sorting technique for implantable, multi-channel neural implant is proposed. It involves spiking neural network (SNN) with binary weights as an energy and area efficient classifier, along with a suitable frontend for spike encoding of the recorded neuro-potential. The proposed scheme emp... |
Alarm fatigue has been linked to patient morbidity and mortality in hospitals due to delayed or absent responses to monitor alarms. We sought to describe alarm rates at 5 freestanding children’s hospitals during a single day and the types of alarms and proportions of patients monitored by using a point-prevalence, cros... |
This article presents the results of treatment of patients with ulcerative gastroduodenal bleeding who were treated in the 2nd clinic (surgery for the improvement of doctors) Military Medical Academy at the I.I. Dzhanelidze Research Institute of Emergency Medicine. A retrospective analysis was conducted of the frequenc... |
In this report we used Northern blot hybridization analysis to characterize the fate of several species of viral RNA transcribed from internal and terminal regions of vaccinia DNA in interferon-treated, infected mouse L cells grown in suspension. All species of viral RNAs were expressed but were reduced in amount. Larg... |
Necrotizing fasciitis is a rapidly progressive, potentially fatal infection of the superficial fascia and subcutaneous tissue. It is rare in children. We report three such cases in which differentiating from common soft tissue infection was challenging. High index of suspicion is important as management initiated at an... |
We have previously reported that connexin (Cx) 32 gene, a member of gap junctions, was specifically downregulated in human renal cell carcinoma (RCC) and it acts as a tumor suppressor against RCC. Because there is no standard therapy for advanced RCC, we investigated the anti‐metastatic effect of Cx32 to seek a possibi... |
Europe is currently transitioning to digital terrestrial television and is aimed to replace all analog infrastructures by 2012. Besides replacing all broadcasting networks in Europe, the transition requires updating household televisions and antennas. As with any major change, public administrations must keep citizens ... |
Background and importance In Portugal, all new drugs, after EMA approval, undergo a national health technology assessment process to decide their reimbursement status, by the SNS (Portuguese National Health System). Aim and objectives The objective of this study was characterisation of the drug approval processes for c... |
Nucleolin is an abundant nucleolar protein involved in several steps of ribosome biogenesis. The protein is highly conserved through evolution and possesses four RNA-binding domains (RBD), which are likely to determine its RNA binding specificity. Previous studies have shown that nucleolin interacts with two different ... |
The complex of mathematical models on which the further organization of the dual learning process is based is proposed in the paper. It is the basis for creation an intellectual superstructure of an integrated environment for the developer of student-centered learning systems, which allows you to solve the tasks of dyn... |
The gene encoding Bacillus subtilis UMP kinase (pyrH/smbA) is transcribed in vivo into a functional enzyme, which represents approximately 0.1% of total soluble proteins. The specific activity of the purified enzyme under optimal conditions is 25 units.mg-1 of protein. In the absence of GTP, the activity of B. subtilis... |
A fictitious patient, Mr. Challenge, is admitted to the emergency room and displays symptoms consistent with damage to the central nervous system. In this problem-based learning case, students are challenged to determine the location of a lesion that is consistent with Mr. Challenge's symptoms. Students discover detail... |
Generally, the measurements of modern industries are collected from different sources, which indicates that the traditional multivariate statistical process monitoring methods cannot be directly used in the multirate systems if one aims to utilize the complete multirate measurements. Hence, a set of multirate factor an... |
A general dilaton gravity theory in 1+1 spacetime dimensions, with a cosmological constant $\ensuremath{\lambda}$ and a new dimensionless parameter $\ensuremath{\omega}$, contains as special cases the constant curvature theory of Teitelboim and Jackiw, the theory equivalent to vacuum planar general relativity, the firs... |
Chemotherapeutics often failed to elicit optimal antitumor responses against lung cancer due to their limited exposure and accumulation in tumors. To achieve an effective therapeutic outcome of paclitaxel (PTX) against metastatic lung cancer with attenuated systemic and local toxicities, pulmonary delivery of redox-res... |
Genetic engineering strategies were applied to synthesize silk-like materials, [(GVPGV)(2)GG(GAGAGS)(3)AS](n). The primary structure of these materials represents the repetitive crystalline region of Bombyx mori silk fibroins incorporated with an elastic motif selected from animal elastin. The oligonucleotides were des... |
BiFeO3 and Eu/Co doped BiFeO3 thin films have been grown on Nb:SrTiO3 substrates with pulsed laser deposition using the same growth conditions. It was shown that the characteristic of resistive switching would be enhanced by Co doping. By changing the polarity of the external voltage, the BiFe0.95Co0.05O3 is witched be... |
Abstract This paper describes the definitions and differences of the computational methods of virial stress and engineering stress in nano-scale problems. According to simulation results of tensile testing of a single-crystalline nano-scale copper bar, the average stresses in a cross-section of the copper bar, calculat... |
The performance of ski jumping has a strong correlation to the in-run speed at take-off, which is underpinned by multi-disciplinary principles. Conventional research on the aerodynamics of ski jumping is supported by wind tunnels while the fluid physics leading to the performance is underexplored. Using computational f... |
Cardiac and Thermal Strain of Elderly Adults Exposed to Extreme Heat and Humidity With and Without Electric Fan Use Heat-related morbidity and mortality are important health challenges posed by global climate change.1 Electric fans provide a low-cost and accessible cooling intervention, although their effectiveness rem... |
The Making Connections, Making Choices program is a multidisciplinary, neuroscience-focused project aimed at middle-school students and teachers primarily throughout Washington State and also across the country. The three components--the Summer Institute (for teacher training), the Brain Power Van (to visit schools and... |
Models of basic types of epileptic seizures are elaborated not only in adult but also in immature rodents. It is important because at least half of human epilepsies starts during infancy and childhood. This paper presents a review of chemically and electrically induced models of generalized convulsive and nonconvulsive... |
Previous findings that older drivers engage in strategic self-regulatory behaviors to minimize perceived safety risks are primarily based on survey reports rather than actual behavior. This study analyzed in-car video recording of naturalistic driving of 18 patients with Alzheimer disease (AD) and 20 age-matched contro... |
A method of monitoring was developed to directly measure the intramyocardial pressure and to objectively assess the viability and contractility of a heart allograft before it is harvested, during its period of preservation and following its implantation. Intramyocardial pressure was measured in the subendocardial and s... |
TP53 and NFKB1 genes represent considerable interest as candidate genes of human aging and longevity. The allele and genotype frequency distributions of TP53 R72P (rs1042522) polymorphism and NFKB1 2592 + 58T > A (rs4648110) polymorphism were characterized in groups of men and women of 21-109 years in the given researc... |
The Swedish school education in geography has developed slowly and still focuses on names of, for example, countries and capitals, rather than geographical concepts and processes. To implement the secondary and upper secondary school curricula, teachers need both broad and deep geographical knowledge. For example, teac... |
Twenty-one patients with disseminated colon carcinoma and clinically significant liver metastases were treated with 5-FUDR via hepatic artery infusion (HAI). All patients had previously received systemic chemotherapy consisting of either 5-fluorouracil aone or in combination with other agents. At the time of the initia... |
As the title suggests, this book is about human gestures and their various meanings. On the basis of a pilot study, the authors chose 20 symbolic gestures for in-depth investigation. The local meaning of each of these gestures was determined by means of interviews in 40 localities ranging from the Canary Islands in the... |
Summary A study of stool Escherichia coli in 60 children with gastroenteritis and 18 control children was carried out in Auckland, New Zealand in 1977. Toxigenic strains, heat labile and heat stable, predominated in the stools of only three children, all of whom had concomitant rotavirus. Classical enteropathogenic E. ... |
The amber acid neutralized by 10 % solution of NaOH in a concentration of 250 mmoL/L was administered subcutaneously simultaneously with intraperitonal injection of gentamycin in a doze of 10 mg/kg(bw) once a day during 7 days to the ten nonlinear white male rats, weight 100-120 g exposed to the water-induced diuresis.... |
The present study was undertaken to assess the effects of the rigidity of nails on the healing of fractures as evaluated by mechanical strength and rate of bone mineralisation. Ten rats supplied biomechanical data at the start of the experiment and another 100 rats were randomly assigned to 5 groups. In 20 rats no inte... |
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