text stringlengths 0 10.1k |
|---|
Dissolution rates and apparent solubilities for synthetic hydroxyapatite in acetate buffers containing phosphate and strontium ions in the range of 10-3 to 10-2 M were determined under various pH and buffer conditions. Critical examination of the role of strontium with a physical model suggests that a calcium-strontium... |
Alkaptonuria (AKU) is an autosomal recessive disorder caused by the deficiency of homogentisate 1,2 dioxygenase (HGO) activity. The disease is characterized by homogentisic aciduria, ochronosis and ochronotic arthritis. AKU shows a very low prevalence (1:250 000), in most ethnic groups. Altogether 43 HGO mutations have... |
The yield of commercial gene panels for MODY has been reported as low as 27% suggesting the role of un-identified gene variants in MODY. We aimed to study novel genetic factors of MODY. We identified 10 probands who had clinical characteristics suggestive of MODY (i.e., positive family history of diabetes, negative isl... |
The basal ganglia participate with cortex and thalamus in recurrent regulatory loops that promote particular movements and inhibit premature or inappropriate movements. The output nuclei of the basal ganglia, including the substantia nigra pars reticulata (SNr), provide inhibitory output to the thalamus, including the ... |
We found a gap mode plasmon induced photocatlaytic oxidation of p-alkyl thiophenol (p-AlTP) to p-mercaptobenzoic acid (p-MBA). In contrast to p-AlTP, o-methyl TP and m-methyl TP were not oxidized, indicating preferential reactivity of the para position in TP molecules. Nonetheless, the site selectivity is not always va... |
A new solid-sate donor-acceptor system based on periodic mesoporous organosilica (PMO) has been constructed. Viologen (Vio) was covalently attached to the framework of a biphenyl (Bp)-bridged PMO. The diffuse reflectance spectrum showed the formation of charge-transfer (CT) complexes of Bp in the framework with Vio in ... |
It has been demonstrated histochemically that endothelial cells of the cerebral capillaries show a high activity in gamma-glutamyl transpeptidase (gamma-GT), an enzyme which takes part in the transfer of large neutral amino acids across the blood-brain barrier. Reports of the disappearance of enzyme activity in endothe... |
Existing theories do not explain large parallel electric fields that are associated with keV electron precipitation in auroral arcs. The MHD electron response results in an electrical conductivity in the low altitude magnetosphere that is two orders of magnitude greater than is required. We suggest a new mechanism for ... |
Elevated levels of epidermal growth factor receptor (EGFR) are predictive of increased invasion and metastasis in many human cancers. In the present study, we have shown that two distinct pathways regulate cell migration in EGFR-overexpressing invasive cells such as MDA 468 breast cancer cells: mitogen-activated protei... |
Rare case of Morgagni hernia presenting with cyanotic spells in a neonate Mustafa Sher , Saikiran Gopalakaje, Robert Justo , Kelvin Choo and Nitin Kapur School of Medicine, Griffith University, Gold Coast, Respiratory Division, Queensland Children’s Hospital, Surgery Division, Mater Children’s Private Hospital, Brisban... |
Low‐grade bone marrow edema (BME) has been reported in the sacroiliac (SI) joints of 25% of healthy individuals and patients with nonspecific mechanical back pain, thus challenging the specificity and predictive value of magnetic resonance imaging (MRI) for the discrimination of early spondyloarthritis (SpA). It is unk... |
4109 Background: Advanced or recurrent stomach cancer remains an incurable disease and little progress has been obtained in prolonging survival. Multiple drugs and combinations of chemotherapy (CT) have been investigated with limited benefit on overall survival. The GASTRIC project initiated an individual-patient-data ... |
METHODS |
Randomized clinical trials (RCT) closed to patient accrual before 2004 were searched based on predefined criteria. The primary endpoint was overall survival (OS), the secondary progression-free-survival (PFS). The log-rank test, stratified by trial, was used to compare treatment arms; Peto heterogeneity tests were used... |
RESULTS |
Fifty RCTs (N = 7,746) were identified, IPD (N = 4,245) was available from 22 studies. In the comparison of experimental with the control arms, highly significant differences were observed. Addition of a compound also showed a significant improvement in OS and PFS. There was no specific regimen which showed statistical... |
CONCLUSIONS |
This IPD meta-analysis showed that OS and PFS have been modestly but significantly improved by the addition of experimental CT agents to preexisting control or standard regimens, but no specific regimen was identified as clearly superior. [Table: see text].[Visualization of enlarged parathyroids by digital subtraction ... |
Digital Subtraction Angiography (DSA) is a suitable method for visualising hypercrinal parathyroid glands on account of its high power of resolution. Hyperperfused areas stand out in contrast when using largely standardised imaging techniques with peripheral venous injection of contrast medium. Whereas 15 of 17 hyperpl... |
The new members of the Ag2-xNaxMn2Fe(VO4)3 (0 ≤ x ≤ 2) solid solution were synthesized by a solid-state reaction route, and their crystal structures were determined from single-crystal X-ray diffraction data. The physical properties were characterized by Mössbauer and electrochemical impedance spectroscopies, galvanost... |
Previous publications have demonstrated conflicting results regarding body mass index (BMI) and prostate cancer (CaP) outcomes after definitive radiotherapy (RT) before the dose escalation era. The goal of the current study was to determine whether increasing BMI was associated with outcomes in men with localized CaP w... |
One of the most telling features of the application of combinatorics on words in mathematical music theory is the extent to which aspects of the history of theory are captured by the word theory model. Well-formed modes, including the usual diatonic modes, are modeled by Christoffel words and their conjugates. A class ... |
Catholic Progressives in England After Vatican II. By Jay P Corrin. (Notre Dame, IN: University of Notre Dame Press. 2013. Pp. x, 523. $49.00 paperback. ISBN 978-0-268-02310-2.)We English Catholics are well-trained in the art of keeping our heads down. Perhaps it is the result of a long-history of state persecution of ... |
INTRODUCTION |
The quality of care is especially relevant to patients with inflammatory bowel disease (IBD) and may be used in the context of quality management and for evaluation of interventions in health services research. To the best of our knowledge no German disease-specific and validated tool exists to measure the quality of t... |
METHODS |
QUOTE-IBD is a validated questionnaire to assess the disease-specific quality of care from an IBD patient's perspective. It was translated into German and validated after being answered by 100 patients of our IBD outpatient clinic. To assess convergent validity a visual analogue scale and the Qualiskope-A questionnaire... |
RESULTS |
The German QUOTE-IBD questionaire was very well accepted by patients and showed reliability in measuring overall satisfaction. Good correlations between overall satisfaction and the visual analogue scale as well as patient satisfaction measured by the Qualiskope A could be demonstrated. The mean overall satisfaction am... |
DISCUSSION |
With the German QUOTE-IBD questionaire there is now a reliable and valid instrument available for measuring quality of care and satisfaction from the perspective of patients with chronic inflammatory bowel disease.CYP2B6 genotype, but not rifampicin-based anti-TB cotreatments, explains variability in long-term efaviren... |
AIM |
We investigated the effects of rifampicin-based anti-TB treatment on plasma efavirenz exposure and the implications of CYP2B6 genotype. |
PATIENTS & METHODS |
Antiretroviral therapy-naive Ugandan HIV patients without (n = 157) or with TB coinfection (n = 106) were enrolled and treated with efavirenz-based highly active antiretroviral therapy alone or with rifampicin-based anti-TB therapy, respectively. Efavirenz plasma concentration was determined on day 3 and weeks 1, 2, 8,... |
RESULTS |
Rifampicin-based anti-TB cotreatment reduced plasma efavirenz exposure during the first 2 weeks (p < 0.05), but no significant effect was observed afterwards. Although not significant, rifampicin-based anti-TB cotreatment inconsistently increased efavirenz exposure over time, which was reduced immediately after complet... |
CONCLUSION |
Plasma efavirenz exposure is mainly influenced by CYP2B6 genotype, but not by rifampicin cotreatment. Therefore, no efavirenz dosage adjustment during rifampicin cotreatment is required in Ugandans.Chemical modification of lactase for immobilization on carboxylic acid-functionalized microspheres |
Abstract Surface interactions between an enzyme and support influence the retention of activity after immobilization. Chemical modification of enzymes prior to immobilization may be used to alter these interactions and enhance activity retention. Lactase (A. oryzae) was covalently conjugated to P(S/V-COOH) microspheres... |
In the last years, the adherence adnexal disease has been increased due to pelvic infections. This may cause infertility problems depending, of the nature, extension and localization inside the pelvis. In this paper we inform the results obtained in 70 patients with adnexal adhesions to whom it was performed a salpingo... |
A method has been developed for real-time measurement of nitrogen atom density in atmospheric pressure post-discharge flows. In this method, nitric oxide is supplied to the downstream of a nitrogen discharge as a reactant. Our chemical simulation has revealed that the injected nitric oxide is consumed mainly by reducti... |
To evaluate the roles of counterregulatory hormones and insulin antibodies in the impairment of plasma glucose recovery from hypoglycemia in diabetes mellitus, and to assess the relationship between the glucagon response and duration of the disease, 21 insulin-dependent diabetic patients and 10 nondiabetic subjects wer... |
Two key challenges exist in high dynamic range (HDR) imaging from multiexposure low dynamic range (LDR) images for dynamic scenes: 1) aligning the input images with large-scale foreground motions and 2) recovering large saturated regions from a limited number of input LDR images. To tackle these challenges, several dee... |
In 81 patients with acute abdominal pain, laparoscopy was performed because of diagnostic doubt. Diagnosis by clinical methods proved to be correct in 42 of the patients and laparoscopy gave correct diagnosis in 70. Appendectomy revealed acute appendicitis in 19 patients and normal appendix in five. Failure to establis... |
AmpC ss-lactamases are active-site serine enzymes that are primarily cephalosporinases. In many gram negative organisms, including Enterobacter spp.,Citrobacter freundii, Serratia marcescens, Morganella morganii and Pseudomonas aeruginosa, the expression of chromosomal ampC genes is low but inducible in response to ss-... |
While religious politics have been a widely discussed topic in the social sciences in recent decades, few studies develop general explanations based on systematic and detailed comparative analysis. This article seeks to explain when and how successful religious parties rise. To that end, I comparatively analyze the pol... |
OBJECTIVE |
MicroRNAs (miRNAs) are part of a class of small ribonucleic acid (RNAs). They are important regulatory molecules, involved in several cell processes, such as developmental timing, stem cell division and apoptosis. Dysregulated miRNAs have been identified in several human malignancies, including bladder cancer tissue sa... |
METHODS |
Voided urine samples were collected from patients with urothelial carcinoma just prior to bladder tumour resection, as well as age-matched healthy control patients. Pathology demonstrated both low- and high-grade cancer. Total RNA was isolated and quantitative reverse transcriptase-polymerase chain reaction was perform... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.