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the arthritis induced by the cloned t cells showed aspects of a delayed type hypersensitivity reaction characterized by an intense infiltrate which resembles the inflammation in the human rheumatoid joint .
nichd_parent_of
{ "id": "C0003864", "name": "arthritis", "pos": [ 4, 13 ] }
{ "id": "C0003873", "name": "inflammation", "pos": [ 162, 174 ] }
these antibodies react in elisa , western blot and immunofluorescence in an identical way to serum and murine monoclonal anti-la antibodies and show no reaction with the ro antigen .
nichd_parent_of
{ "id": "C0003241", "name": "antibodies", "pos": [ 6, 16 ] }
{ "id": "C0443933", "name": "anti-la antibodies", "pos": [ 121, 139 ] }
the antisperm antibody titers ( si50 ) in sera determined by the quantitative sperm immobilization test ranged from 20 to 243 units while those in follicular fluids ranged from 21 to 160 units in the patients with the immunological factor .
nichd_parent_of
{ "id": "C0392762", "name": "quantitative", "pos": [ 65, 77 ] }
{ "id": "C1514721", "name": "ranged", "pos": [ 165, 171 ] }
changes in plasma oxytocin , prostaglandin e1 , and 13,14-dihydro-15-keto-prostaglandin f2 alpha during labor induced by prostaglandin e2 or f2 alpha and spontaneous labor .
nichd_parent_of
{ "id": "C0022864", "name": "labor", "pos": [ 104, 109 ] }
{ "id": "C0474461", "name": "spontaneous labor", "pos": [ 154, 171 ] }
to observe the changes in endogenous oxytocics during spontaneous and induced labor , the plasma concentrations of oxytocin , prostaglandin e1 ( pge1 ) and 13,14-dihydro-15-keto-prostaglandin f2 alpha ( pgfm ) were measured during labor in 9 cases of spontaneous labor ( group 1 ) , 10 of pge2-induced labor ( group 2 ) ...
nichd_parent_of
{ "id": "C0022864", "name": "labor", "pos": [ 78, 83 ] }
{ "id": "C0474461", "name": "spontaneous labor", "pos": [ 251, 268 ] }
we describe the coagulopathy of a 65-year-old woman with a thrombotic disorder associated with dysfibrinogenemia and lupus anticoagulant ( la ) .
nichd_parent_of
{ "id": "C0005779", "name": "coagulopathy", "pos": [ 16, 28 ] }
{ "id": "C1260903", "name": "dysfibrinogenemia", "pos": [ 95, 112 ] }
both groups were also educated about the evidence against ordering other tests routinely , such as x-ray examinations and blood tests .
nichd_parent_of
{ "id": "C0022885", "name": "tests", "pos": [ 73, 78 ] }
{ "id": "C0018941", "name": "blood", "pos": [ 122, 127 ] }
among patient risk factors -- including operation , body habitus , smoking habits , history of asthma , age , and airway characteristics -- an association with moderate hypoxemia was found only with nonlaparoscopic gynecologic operation , obesity , and age over 35 years , and an association with severe hypoxemia was fo...
nichd_parent_of
{ "id": "C0543467", "name": "operation", "pos": [ 40, 49 ] }
{ "id": "C0038902", "name": "gynecologic operation", "pos": [ 215, 236 ] }
the effects of fluorescein , methylene blue , and indocyanine green on hemodynamic variables and on pulse oximetry and co-oximetry measurements of arterial hemoglobin oxygen saturation ( sao2 ) and oxyhemoglobin percentage ( % hbo2 ) were evaluated in 16 anesthetized dogs in vitro by co-oximetry ( % hbo2 ) and in vivo ...
nichd_parent_of
{ "id": "C0523807", "name": "oximetry", "pos": [ 106, 114 ] }
{ "id": "C0034108", "name": "pulse oximetry", "pos": [ 323, 337 ] }
methylene blue caused dose-dependent decreases in measurements made with both forms of oximetry for up to 30 minutes , the decrease being greater and longer lasting with pulse oximetry ( p less than 0.05 ) .
nichd_parent_of
{ "id": "C0523807", "name": "oximetry", "pos": [ 87, 95 ] }
{ "id": "C0034108", "name": "pulse oximetry", "pos": [ 170, 184 ] }
we offer an explanation for such exceptional scintigraphic finding , which may potentially enable us to make a pre-operative diagnosis of renal oncocytoma in the future .
nichd_parent_of
{ "id": "C0037088", "name": "finding", "pos": [ 59, 66 ] }
{ "id": "C0011900", "name": "diagnosis", "pos": [ 125, 134 ] }
we conclude hematuria is a serious finding in burn patients and prompt diagnosis of its etiology and treatment are essential for maintaining renal function and patient survival .
nichd_parent_of
{ "id": "C0037088", "name": "finding", "pos": [ 35, 42 ] }
{ "id": "C0011900", "name": "diagnosis", "pos": [ 71, 80 ] }
sixty-one children and infants who had significant gastroesophageal reflux and associated complications underwent 73 surgical procedures to control the reflux .
nichd_parent_of
{ "id": "C0008059", "name": "children", "pos": [ 10, 18 ] }
{ "id": "C0021270", "name": "infants", "pos": [ 23, 30 ] }
in order to evaluate the procedure , several esophageal manograms were obtained from each patient , before , during , and after the operation .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 25, 34 ] }
{ "id": "C0543467", "name": "operation", "pos": [ 132, 141 ] }
the procedure involves the insertion of a harpoon-shaped metallic thread , after detection by mammography , to obtain guidance of surgical procedures .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 4, 13 ] }
{ "id": "C0543467", "name": "surgical procedures", "pos": [ 130, 149 ] }
all births at bmh hong kong during one year were analysed retrospectively according to ethnic group , birthweight , length and head circumference .
nichd_parent_of
{ "id": "C1444754", "name": "length", "pos": [ 116, 122 ] }
{ "id": "C0262499", "name": "head circumference", "pos": [ 127, 145 ] }
during 1985 , linear-array ultrasonography was used to study early pregnancy loss in commercial brood mares : 600/1115 ( 54 % ) of the cycles resulted in detected pregnancy at week 2 after ovulation and 80 ( 13 % ) of these pregnancies resulted in early pregnancy loss .
nichd_parent_of
{ "id": "C0032972", "name": "resulted", "pos": [ 142, 150 ] }
{ "id": "C3830362", "name": "early pregnancy loss", "pos": [ 248, 268 ] }
previous studies of the metameric pattern in mesodermal tissues of chick , mouse , turtle , and amphibian embryos have indicated that segmental characteristics exist along the entire length of the embryo .
nichd_parent_of
{ "id": "C1521970", "name": "characteristics", "pos": [ 144, 159 ] }
{ "id": "C1444754", "name": "length", "pos": [ 183, 189 ] }
the changes of morphological and functional variables of both muscles parallel each other as is apparent from the index of antagonist characteristics , which is constant for all variables studied with the exception of muscle volume and tendon length .
nichd_parent_of
{ "id": "C1521970", "name": "characteristics", "pos": [ 134, 149 ] }
{ "id": "C1444754", "name": "length", "pos": [ 243, 249 ] }
although the overall cancer incidence was not elevated , the risk of primary liver cancer was significantly elevated for this group ( standard incidence ratio = 238 ) .
nichd_parent_of
{ "id": "C0006826", "name": "cancer", "pos": [ 21, 27 ] }
{ "id": "C0024620", "name": "the", "pos": [ 57, 60 ] }
pulmonary tumor embolism is a common finding at autopsy but is generally perceived as a difficult diagnosis to make ante mortem .
nichd_parent_of
{ "id": "C0037088", "name": "finding", "pos": [ 37, 44 ] }
{ "id": "C0011900", "name": "diagnosis", "pos": [ 98, 107 ] }
since moloney virus is thought to induce mostly t-cell lymphomas , we have carried out studies to investigate this alteration of disease specificity and to determine whether v-abl played an obligatory role in the development of these tumors .
nichd_parent_of
{ "id": "C0012634", "name": "disease", "pos": [ 129, 136 ] }
{ "id": "C0027651", "name": "tumors", "pos": [ 234, 240 ] }
most sera from older persons who may have been exposed to a natural poliovirus infection before the introduction of the poliovirus vaccines as well as sera from children infected with type 3 poliovirus during the recent outbreak in finland were able to neutralize the trypsin-cleaved type 3 polioviruses .
nichd_parent_of
{ "id": "C0027361", "name": "persons", "pos": [ 21, 28 ] }
{ "id": "C0008059", "name": "children", "pos": [ 161, 169 ] }
in noninfectious diseases , examples include cataract in moose ( alces alces ) , atherosclerosis in hybrid hares ( lepus timidus x l. europaeus ) , and ethmoid tumors in moose .
nichd_parent_of
{ "id": "C0012634", "name": "diseases", "pos": [ 17, 25 ] }
{ "id": "C0027651", "name": "tumors", "pos": [ 160, 166 ] }
we conducted hemostatic studies with 1,043 adult patients with various diseases who were treated for their infection with cefotaxime ( ctx ) in 368 hospitals throughout japan .
nichd_parent_of
{ "id": "C0012634", "name": "diseases", "pos": [ 71, 79 ] }
{ "id": "C0009450", "name": "infection", "pos": [ 107, 116 ] }
underlying diseases in 1,012 patients were nonhematological disorders and those in 31 were hematological diseases .
nichd_parent_of
{ "id": "C0012634", "name": "disorders", "pos": [ 60, 69 ] }
{ "id": "C0018939", "name": "hematological diseases", "pos": [ 91, 113 ] }
[ bronchial asthma due to non-allergic mechanisms -- pathogenesis and clinical characteristics -- 1 ) asthma due to infections with special reference to virus infections ] .
nichd_parent_of
{ "id": "C3714514", "name": "infections", "pos": [ 116, 126 ] }
{ "id": "C0042769", "name": "virus", "pos": [ 153, 158 ] }
[ quantification and progression of the visual field defect in glaucoma without hypertension , glaucoma simplex and pigmentary glaucoma . a clinical study with the delta program of the 201 octopus perimeter ] .
nichd_parent_of
{ "id": "C0017601", "name": "glaucoma", "pos": [ 63, 71 ] }
{ "id": "C0017612", "name": "pigmentary glaucoma", "pos": [ 116, 135 ] }
laboratory findings like severe metabolic acidosis , hyperammonemia , hyperglycinemia , ketonuria and elevated urinary excretion of lactate and propionate suggested the presence of organoacidopathia .
nichd_parent_of
{ "id": "C0587081", "name": "laboratory findings", "pos": [ 0, 19 ] }
{ "id": "C0162275", "name": "ketonuria", "pos": [ 88, 97 ] }
the sst which can be performed under routine clinical conditions , is a useful procedure for evaluating the individual s-dose necessary to achieve normoglycemia .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 79, 88 ] }
{ "id": "C0220825", "name": "evaluating", "pos": [ 93, 103 ] }
the quantitative method employs quinidine as an internal standard and the calibration line is linear between 0.2 and 2.0 mg/l serum , the usual range encountered in patients treated with the drug .
nichd_parent_of
{ "id": "C0392762", "name": "quantitative", "pos": [ 4, 16 ] }
{ "id": "C1514721", "name": "range", "pos": [ 144, 149 ] }
however , presence of cardiac disease , such as heart failure and valvular stenosis has minimal influence on compliance estimates .
nichd_parent_of
{ "id": "C0018799", "name": "cardiac", "pos": [ 22, 29 ] }
{ "id": "C0018801", "name": "heart failure", "pos": [ 48, 61 ] }
previous studies with models of deep-vein thrombosis ( dvt ) have demonstrated that leukocyte ( pmn ) -mediated vein injury may be an initiating event in dvt ( 14 , 17 ) .
nichd_parent_of
{ "id": "C0042487", "name": "of", "pos": [ 29, 31 ] }
{ "id": "C0149871", "name": "dvt", "pos": [ 154, 157 ] }
the mayo clinic medical records and records linkage system were used to identify stroke-free residents of rochester , minnesota , who were examined within 30 days after the first transient cerebral ischemic attack ( tia ) during the period 1955 through 1979 .
nichd_parent_of
{ "id": "C0038454", "name": "stroke", "pos": [ 81, 87 ] }
{ "id": "C0007787", "name": "transient cerebral ischemic attack", "pos": [ 179, 213 ] }
death , stroke , and either stroke or tia were separate endpoints in kaplan-meier analyses of data from the day of initial examination through the 30th day thereafter .
nichd_parent_of
{ "id": "C0038454", "name": "stroke", "pos": [ 8, 14 ] }
{ "id": "C0007787", "name": "tia", "pos": [ 118, 121 ] }
the probabilities of survival , survival free from stroke , and survival free from tia for the heparin-treated group were not significantly different from those probabilities for the comparison group .
nichd_parent_of
{ "id": "C0038454", "name": "stroke", "pos": [ 51, 57 ] }
{ "id": "C0007787", "name": "tia", "pos": [ 83, 86 ] }
the authors recommend abscess tonsillectomy at one time and on both tonsils as treatment of choice in peritonsillar abscess without restriction .
nichd_parent_of
{ "id": "C0000833", "name": "abscess", "pos": [ 22, 29 ] }
{ "id": "C0031157", "name": "peritonsillar abscess", "pos": [ 102, 123 ] }
this new procedure is simple , convenient , rapid , and safe and provides reproducible information on both oap and flow parameters , which are important indices in the evaluation of severe carotid artery disease .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 9, 18 ] }
{ "id": "C0220825", "name": "evaluation", "pos": [ 168, 178 ] }
neonatal gestational age , birth weight , length and head circumference were not affected by cocaine use compared to methadone use .
nichd_parent_of
{ "id": "C1444754", "name": "length", "pos": [ 42, 48 ] }
{ "id": "C0262499", "name": "head", "pos": [ 53, 57 ] }
significant differences were found between the cocaine and drug-free groups in infant birth weight , length , head circumference and apgar scores , with the cocaine group having lower values for each variable .
nichd_parent_of
{ "id": "C1444754", "name": "length", "pos": [ 101, 107 ] }
{ "id": "C0262499", "name": "head circumference", "pos": [ 110, 128 ] }
during six years of follow-up , 65 of the women died of fatal coronary heart disease and 242 had a nonfatal myocardial infarction .
nichd_parent_of
{ "id": "C0018799", "name": "of", "pos": [ 17, 19 ] }
{ "id": "C0027051", "name": "myocardial infarction", "pos": [ 108, 129 ] }
the number of cigarettes smoked per day was positively associated with the risk of fatal coronary heart disease ( relative risk = 5.5 for greater than or equal to 25 cigarettes per day ) , nonfatal myocardial infarction ( relative risk = 5.8 ) , and angina pectoris ( relative risk = 2.6 ) .
nichd_parent_of
{ "id": "C0018799", "name": "the", "pos": [ 0, 3 ] }
{ "id": "C0027051", "name": "myocardial infarction", "pos": [ 198, 219 ] }
in a retrospective cohort study of survivors of cancer and of controls , we estimated the risk of infertility after treatment for cancer during childhood or adolescence .
nichd_parent_of
{ "id": "C0231335", "name": "childhood", "pos": [ 144, 153 ] }
{ "id": "C0001578", "name": "adolescence", "pos": [ 157, 168 ] }
to test the hypothesis that prolonged cardiac repolarization may characterize some babies who die of sudden infant death syndrome ( sids ) , we studied the dependence of the qt interval on the preceding rr interval in 10 babies with sids and 29 healthy control babies .
nichd_parent_of
{ "id": "C0011065", "name": "die", "pos": [ 94, 97 ] }
{ "id": "C0038644", "name": "sids", "pos": [ 233, 237 ] }
although some symptoms of post-traumatic stress disorder , such as hyperalertness and sleep disturbances , occurred commonly in the general population , the full syndrome as defined by the diagnostic and statistical manual of mental disorders , third edition , was common only among veterans wounded in vietnam .
nichd_parent_of
{ "id": "C0012634", "name": "disorder", "pos": [ 48, 56 ] }
{ "id": "C0039082", "name": "syndrome", "pos": [ 162, 170 ] }
features compared between the two groups included sodium , glucose , temperature , diabetes insipidus , major complications , neurological deficits and death .
nichd_parent_of
{ "id": "C1521970", "name": "features", "pos": [ 0, 8 ] }
{ "id": "C0039476", "name": "temperature", "pos": [ 69, 80 ] }
patients with headaches that are a mixture of tension headache and migraine , and migraineurs who have interval headaches which are not clearly differentiated from migraine should be excluded .
nichd_parent_of
{ "id": "C0018681", "name": "headaches", "pos": [ 14, 23 ] }
{ "id": "C0149931", "name": "migraine", "pos": [ 164, 172 ] }
early ( es1 ) and late ( es2 ) exteroceptive suppression periods elicited by electrical stimulation of the labial commissure during teeth-clenching were recorded over the temporalis muscle in 45 headache patients ( 25 tension headaches and 20 migraines ) and 22 controls .
nichd_parent_of
{ "id": "C0018681", "name": "headache", "pos": [ 195, 203 ] }
{ "id": "C0033893", "name": "tension", "pos": [ 218, 225 ] }
early ( es1 ) and late ( es2 ) exteroceptive suppression periods elicited by electrical stimulation of the labial commissure during teeth-clenching were recorded over the temporalis muscle in 45 headache patients ( 25 tension headaches and 20 migraines ) and 22 controls .
nichd_parent_of
{ "id": "C0018681", "name": "headache", "pos": [ 195, 203 ] }
{ "id": "C0149931", "name": "migraines", "pos": [ 243, 252 ] }
seizures that were consistently and coherently related to focal eeg seizure activity had a high correlation with focal brain lesions and a favorable short-term outcome .
nichd_parent_of
{ "id": "C0036572", "name": "seizures", "pos": [ 0, 8 ] }
{ "id": "C0751495", "name": "focal", "pos": [ 113, 118 ] }
currently , the rates of eye disease such as cataract , macular degeneration , diabetic retinopathy , and glaucoma are highest in the older group .
nichd_parent_of
{ "id": "C0015397", "name": "the", "pos": [ 12, 15 ] }
{ "id": "C0086543", "name": "cataract", "pos": [ 45, 53 ] }
currently , the rates of eye disease such as cataract , macular degeneration , diabetic retinopathy , and glaucoma are highest in the older group .
nichd_parent_of
{ "id": "C0015397", "name": "the", "pos": [ 12, 15 ] }
{ "id": "C0017601", "name": "glaucoma", "pos": [ 106, 114 ] }
a randomized controlled trial was conducted to evaluate two interventions for prolonging the duration of breast-feeding in a multiethnic sample of 343 low-income urban women .
nichd_parent_of
{ "id": "C0004927", "name": "conducted", "pos": [ 34, 43 ] }
{ "id": "C0006147", "name": "breast-feeding", "pos": [ 105, 119 ] }
after analysing the various lesions and discussing the probable pathogenesis we grouped according to the following scheme : i ) tumor-unrelated ( casual coincidence ) ( 43.2 % ) , ii ) therapy-dependent ( 3.7 % ) , iii ) agony-related ( 10.7 % ) , iv ) homoiogenic disorders ( e.g . larynx carcinoma and wernicke 's dise...
nichd_parent_of
{ "id": "C0012634", "name": "disorders", "pos": [ 265, 274 ] }
{ "id": "C0027651", "name": "tumor", "pos": [ 381, 386 ] }
on retrospective analysis , the cancers with elevated c-myc transcripts were found to have a gleason score of 5 and above ( poorly differentiated tumors ) , while the cancers with little or no c-myc transcripts were all of gleason score 4 and lower .
nichd_parent_of
{ "id": "C0027651", "name": "tumors", "pos": [ 146, 152 ] }
{ "id": "C0006826", "name": "cancers", "pos": [ 167, 174 ] }
primary care physicians felt that they should treat most patients with less severe ( comedonal and papulopustular ) acne and were neutral about referral of patients with nodulocystic acne .
nichd_parent_of
{ "id": "C0087111", "name": "treat", "pos": [ 46, 51 ] }
{ "id": "C0034927", "name": "referral", "pos": [ 144, 152 ] }
growth hormone status and growth characteristics of japanese quail divergently selected for four-week body weights .
nichd_parent_of
{ "id": "C1521970", "name": "characteristics", "pos": [ 33, 48 ] }
{ "id": "C0005910", "name": "body weights", "pos": [ 102, 114 ] }
since the majority of cases ( 85 per cent ) was associated with grossly normal phenotype and the abnormalities noted in 15 per cent of cases were inconsistent and rather non-specific , no casual relationship between trisomy 20 mosaicism and a specific malformation syndrome can be established .
nichd_parent_of
{ "id": "C0000768", "name": "abnormalities", "pos": [ 97, 110 ] }
{ "id": "C1302790", "name": "malformation syndrome", "pos": [ 252, 273 ] }
hereditary complement deficiency in survivors of meningococcal disease : high prevalence of c7/c8 deficiency in sephardic ( moroccan ) jews .
nichd_parent_of
{ "id": "C0019247", "name": "hereditary", "pos": [ 0, 10 ] }
{ "id": "C0272242", "name": "complement deficiency", "pos": [ 11, 32 ] }
with increasing familiarity with the clinical features of this hereditary disease , it is possible now to identify on clinical grounds patients with meningococcal disease with a high likelihood of terminal complement deficiency .
nichd_parent_of
{ "id": "C0019247", "name": "hereditary disease", "pos": [ 63, 81 ] }
{ "id": "C0272242", "name": "of", "pos": [ 194, 196 ] }
this procedure allows the radiologist to evaluate the small bowel for disease processes including crohn 's disease , meckel 's diverticulum , and malabsorption diseases -- all disease processes sometimes missed through single contrast sbft .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 5, 14 ] }
{ "id": "C0220825", "name": "evaluate", "pos": [ 41, 49 ] }
even though the procedure is costly and time consuming , it provides a more accurate evaluation of the small bowel .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 16, 25 ] }
{ "id": "C0220825", "name": "evaluation", "pos": [ 85, 95 ] }
preoperatively the following diagnostic procedures were used : chest film examination in 82 , plain film of the abdomen in 64 , contrast radiographs of the gastrointestinal tract in 21 , ultrasonography in 37 , computed tomography in 8 and angiography in 9 patients .
nichd_parent_of
{ "id": "C0430022", "name": "diagnostic procedures", "pos": [ 29, 50 ] }
{ "id": "C0041618", "name": "ultrasonography", "pos": [ 187, 202 ] }
blood flow in several types of tumors ( two hepatomas , two hemangiomas , two renal cell carcinomas , one hydatidiform mole , and five invasive moles ) was assessed with real-time two-dimensional color doppler echography ( ultrasound ) .
nichd_parent_of
{ "id": "C0020217", "name": "hydatidiform mole", "pos": [ 106, 123 ] }
{ "id": "C0008493", "name": "invasive moles", "pos": [ 135, 149 ] }
increased amounts of 12-hydroxy-5,8,10,14-eicosatetraenoic acid ( 12-hete ) are found in the lesional skin of patients with the skin disease psoriasis when compared to clinically normal skin .
nichd_parent_of
{ "id": "C0037274", "name": "skin disease", "pos": [ 128, 140 ] }
{ "id": "C0033860", "name": "psoriasis", "pos": [ 141, 150 ] }
moreover , psychological data were collected through rorschach ink blot test among 42 headache sufferers ( 31 m and 11 th ) .
nichd_parent_of
{ "id": "C0018681", "name": "headache", "pos": [ 86, 94 ] }
{ "id": "C0033893", "name": "th", "pos": [ 119, 121 ] }
the clinical findings and etiologic agents of childhood pneumonia vary , dependent upon the age of the child , with major differences seen in neonates , young infants 1 to 3 months of age , older infants or young children 3 months to 5 years of age , and older children or adolescents .
nichd_parent_of
{ "id": "C0008059", "name": "child", "pos": [ 46, 51 ] }
{ "id": "C0021270", "name": "infants", "pos": [ 196, 203 ] }
the protection against disease imparted by pertussis vaccines may be greater than that against infection .
nichd_parent_of
{ "id": "C0012634", "name": "disease", "pos": [ 23, 30 ] }
{ "id": "C0009450", "name": "infection", "pos": [ 95, 104 ] }
after the organisms penetrate the nonspecific mechanical and cleansing forces , ligands ( or adhesins ) on the surface of the bacteria interact in a lock-and-key ( or induced-fit ) fashion with complementary receptors on mucosal surfaces of the host .
nichd_parent_of
{ "id": "C0029235", "name": "organisms", "pos": [ 10, 19 ] }
{ "id": "C0004611", "name": "bacteria", "pos": [ 126, 134 ] }
activated leukocytes and their products play an important role in the pathogenesis of important disorders of the hemostatic system , with disseminated intravascular coagulation as the most prominent example .
nichd_parent_of
{ "id": "C0005779", "name": "of", "pos": [ 83, 85 ] }
{ "id": "C0012739", "name": "disseminated", "pos": [ 138, 150 ] }
thus , inhalation exposure to t-2 toxin can result in clinical signs and morphologic changes resembling those reported previously in pigs given t-2 toxin intravascularly ( iv ) at a dose of 1.2 mg/kg ( approximate ld50 ) or greater , as well as death .
nichd_parent_of
{ "id": "C3540840", "name": "clinical signs", "pos": [ 54, 68 ] }
{ "id": "C0011065", "name": "death", "pos": [ 245, 250 ] }
the consequences of immune dysfunction may be expressed in reduced resistance to infectious and neoplastic diseases , or enhanced hypersensitivity and autoimmunity .
nichd_parent_of
{ "id": "C0021053", "name": "immune", "pos": [ 20, 26 ] }
{ "id": "C0020517", "name": "hypersensitivity", "pos": [ 130, 146 ] }
malignant carcinoid of the small intestine with metastases to the liver , valvular disease of the right side of the heart ( pulmonary stenosis and tricuspid regurgitation without septal defects ) , peripheral vasomotor symptoms , bronchoconstriction , and an unusual type of cyanosis ;
nichd_parent_of
{ "id": "C0018824", "name": "valvular disease of the", "pos": [ 74, 97 ] }
{ "id": "C0040961", "name": "tricuspid regurgitation", "pos": [ 147, 170 ] }
[ a new principle of tumor transmission : transplantation through aspiration of tumor cells and their significance for the problem of intracanalicular metastasization of the cancer ] .
nichd_parent_of
{ "id": "C0027651", "name": "tumor", "pos": [ 21, 26 ] }
{ "id": "C0006826", "name": "cancer", "pos": [ 174, 180 ] }
the use of tadpoles of xenopus laevis as test animals for the assay of melanophore hormone .
nichd_parent_of
{ "id": "C0022885", "name": "test", "pos": [ 41, 45 ] }
{ "id": "C0441683", "name": "assay", "pos": [ 62, 67 ] }
[ resistence of carboxyhemoglobin to alkali and acids in cooley 's disease and related syndromes in newborn and in various morbid conditions ] .
nichd_parent_of
{ "id": "C0012634", "name": "disease", "pos": [ 67, 74 ] }
{ "id": "C0039082", "name": "syndromes", "pos": [ 87, 96 ] }
the hemodynamic analysis of cranial artery pulse wave contours in vascular headache of the migraine type .
nichd_parent_of
{ "id": "C0018681", "name": "headache", "pos": [ 75, 83 ] }
{ "id": "C0149931", "name": "migraine", "pos": [ 91, 99 ] }
[ antitreponema and antilipoid antibodies in serum in mother and in child in congenital syphilis ; studies in the umbilical cord , in newborn , and in infant ] .
nichd_parent_of
{ "id": "C0008059", "name": "child", "pos": [ 68, 73 ] }
{ "id": "C0021289", "name": "newborn", "pos": [ 134, 141 ] }
[ antitreponema and antilipoid antibodies in serum in mother and in child in congenital syphilis ; studies in the umbilical cord , in newborn , and in infant ] .
nichd_parent_of
{ "id": "C0008059", "name": "child", "pos": [ 68, 73 ] }
{ "id": "C0021270", "name": "infant", "pos": [ 151, 157 ] }
in view of the course and the clinical findings in two young patients in whom this diagnosis was established , it is suggested that intramural diverticulosis develops as a result of a devolopmental disorder in the autonomic nervous system .
nichd_parent_of
{ "id": "C0037088", "name": "clinical findings", "pos": [ 30, 47 ] }
{ "id": "C0011900", "name": "diagnosis", "pos": [ 83, 92 ] }
in most cases a differentiation between primary humoral and thrombocytogenic bleeding disorders and a secondary bleeding diathesis due to consumption coagulopathy is possible by means of anamnestic , clinical and laboratory parameters .
nichd_parent_of
{ "id": "C0005779", "name": "bleeding", "pos": [ 77, 85 ] }
{ "id": "C0012739", "name": "consumption coagulopathy", "pos": [ 138, 162 ] }
in a survey of pregnancies , in which a chromosomal abnormality was diagnosed by amniocentesis but in which the mother did not undergo an abortion , the spontaneous fetal death rate after amniocentesis for 21 fetuses with down 's syndrome was 24 per cent ( or 21 per cent , considering 19 singletons only ) .
nichd_parent_of
{ "id": "C0008625", "name": "chromosomal abnormality", "pos": [ 40, 63 ] }
{ "id": "C0013080", "name": "down 's", "pos": [ 222, 229 ] }
[ characteristics of systemic growth regulation of the limbs under the effect of various factors influencing their growth and length ] .
nichd_parent_of
{ "id": "C1521970", "name": "characteristics", "pos": [ 2, 17 ] }
{ "id": "C1444754", "name": "length", "pos": [ 126, 132 ] }
clinical signs ( fever , fatigue , conjunctivitis , chondritis and hoarseness of the voice ) rapidly regressed and remain so 8 months later , despite a decrease in the dose .
nichd_parent_of
{ "id": "C3540840", "name": "clinical signs", "pos": [ 0, 14 ] }
{ "id": "C0015967", "name": "fever", "pos": [ 17, 22 ] }
clinical signs ( fever , fatigue , conjunctivitis , chondritis and hoarseness of the voice ) rapidly regressed and remain so 8 months later , despite a decrease in the dose .
nichd_parent_of
{ "id": "C3540840", "name": "clinical signs", "pos": [ 0, 14 ] }
{ "id": "C0015672", "name": "fatigue", "pos": [ 25, 32 ] }
clinical signs ( fever , fatigue , conjunctivitis , chondritis and hoarseness of the voice ) rapidly regressed and remain so 8 months later , despite a decrease in the dose .
nichd_parent_of
{ "id": "C3540840", "name": "clinical signs", "pos": [ 0, 14 ] }
{ "id": "C0019825", "name": "hoarseness of", "pos": [ 67, 80 ] }
[ determination of the relationship between laryngologic diseases ( especially infectious ) , atopic and non-atopic asthma and chronic obstructive bronchitis ] .
nichd_parent_of
{ "id": "C0012634", "name": "diseases", "pos": [ 57, 65 ] }
{ "id": "C0009450", "name": "infectious", "pos": [ 79, 89 ] }
[ disturbed glucose tolerance and diabetes mellitus in the relatives of patients with the juvenile form of diabetes mellitus ] .
nichd_parent_of
{ "id": "C0011849", "name": "diabetes mellitus", "pos": [ 34, 51 ] }
{ "id": "C0011854", "name": "juvenile", "pos": [ 90, 98 ] }
although the role of colitis colon-bound antibody in the pathogenesis of ulcerative colitis is unclear , local antibody-antigen complexes may initiate colonic epithelial cytolysis by various immunologically mediated mechanisms .
nichd_parent_of
{ "id": "C0009319", "name": "colitis", "pos": [ 21, 28 ] }
{ "id": "C0009324", "name": "ulcerative colitis", "pos": [ 73, 91 ] }
[ statistical methods for the analysis and comprehensive evaluation of the physical development of a children 's collective ] .
nichd_parent_of
{ "id": "C0220825", "name": "evaluation", "pos": [ 57, 67 ] }
{ "id": "C0031809", "name": "physical", "pos": [ 75, 83 ] }
review of hospital and clinic records , although regrettably incomplete , revealed no case of tuberculous meningitis or miliary tuberculosis in a vaccinated child in our area since the campaign for vaccination of newborn babies began .
nichd_parent_of
{ "id": "C0008059", "name": "child", "pos": [ 157, 162 ] }
{ "id": "C0021289", "name": "newborn", "pos": [ 213, 220 ] }
certain forms of cancer , including burkitt 's lymphoma , carcinoma of the cervix , primary liver cancer , acute leukaemia and breast cancer show many characteristics of epidemic disease , and the possibility of producing preventive vaccine against these conditions merits serious consideration .
nichd_parent_of
{ "id": "C0006826", "name": "cancer", "pos": [ 17, 23 ] }
{ "id": "C0302592", "name": "carcinoma of the cervix", "pos": [ 58, 81 ] }
certain forms of cancer , including burkitt 's lymphoma , carcinoma of the cervix , primary liver cancer , acute leukaemia and breast cancer show many characteristics of epidemic disease , and the possibility of producing preventive vaccine against these conditions merits serious consideration .
nichd_parent_of
{ "id": "C0006826", "name": "cancer", "pos": [ 17, 23 ] }
{ "id": "C0024620", "name": "primary liver cancer", "pos": [ 84, 104 ] }
free conidial reproduction found in lymph nodes may suggest the possibility of this disease being infectious , requiring an active and vigorous treatment schedule and control measures in this infection .
nichd_parent_of
{ "id": "C0012634", "name": "disease", "pos": [ 84, 91 ] }
{ "id": "C0009450", "name": "infectious", "pos": [ 98, 108 ] }
the initial diagnosis was based upon this knowledge and clinical signs ( low exercise tolerance and coughing ) .
nichd_parent_of
{ "id": "C3540840", "name": "clinical signs", "pos": [ 56, 70 ] }
{ "id": "C0010200", "name": "coughing", "pos": [ 100, 108 ] }
principles of dental health education is childhood and adolescence are outlined with special regard to priorities related to the age-specific state of dentition development .
nichd_parent_of
{ "id": "C0231335", "name": "childhood", "pos": [ 41, 50 ] }
{ "id": "C0001578", "name": "adolescence", "pos": [ 55, 66 ] }
12 weeks after initial vaccination no clinical signs were seen in three of four cats following intranasal challenge with 10 ( 5 ) ccid50 of virulent field fvr virus , and a mild transient unilateral ocular and nasal discharge was seen in the remaining cat for one day only .
nichd_parent_of
{ "id": "C3540840", "name": "clinical signs", "pos": [ 38, 52 ] }
{ "id": "C1260880", "name": "nasal discharge", "pos": [ 210, 225 ] }
adenylate cyclase activity as well as intracellular content of samp were decreased 2.5-4-fold , as compared with normal state , in plasmatic membranes ( pm ) of hepatoma 22 and of ehrlich ascites carcinoma -- the tumors characterized by high level- of malignancy .
nichd_parent_of
{ "id": "C0027651", "name": "tumors", "pos": [ 213, 219 ] }
{ "id": "C0006826", "name": "malignancy", "pos": [ 252, 262 ] }
at the same time , the ratio was distinctly elevated in tumors with the middle level of malignancy ( hepatomas 60 and 61 ) .
nichd_parent_of
{ "id": "C0027651", "name": "tumors", "pos": [ 56, 62 ] }
{ "id": "C0006826", "name": "malignancy", "pos": [ 88, 98 ] }
these morphological characteristics may be related to the different motion pattern of the basilar membrane along the length of the cochlear duct .
nichd_parent_of
{ "id": "C1521970", "name": "characteristics", "pos": [ 20, 35 ] }
{ "id": "C1444754", "name": "length", "pos": [ 117, 123 ] }