text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
serum neuroleptic levels were measured by radioreceptor assay in patients treated with the antidepressant amoxapine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
91,
105
]
} | {
"id": "C0002644",
"name": "amoxapine",
"pos": [
106,
115
]
} |
the increase in brain antidepressant binding sites is discussed in relationship to other indices of brain serotonergic function in aging and to the relationship of [ 3h ] imipramine binding and depression . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
22,
36
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
171,
181
]
} |
all major antidepressants ( desipramine , amitryptyline or maprotiline ) , several newer compounds with reported antidepressant activity ( viloxazine , zimelidine , fluoxetine , citalopram , progabide , fengabine , sodium valproate , mianserin , trazodone or nomifensine ) as well as pargyline and repeated electroshocks... | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
10,
24
]
} | {
"id": "C0037567",
"name": "sodium",
"pos": [
215,
221
]
} |
its in vitro antibacterial activity was less than those of cefoxitin against peptostreptococcus and veillonella , but was significantly high against bacteroides fragilis , one of the most clinically important anaerobe . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
59,
68
]
} |
chronic ( 14-day ) treatment with reserpine resulted in a significant increase in beta-adrenergic receptor binding in the cerebral cortex and the hippocampus , which was partially prevented by chronic treatment with either the antidepressant imipramine , the gaba-a agonist thip or , the gaba-b agonist baclofen . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
227,
241
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
242,
252
]
} |
the two neuroleptics were similar in acute anti-apomorphine potency ( id50 = 0.12 and 0.18 mg/kg for haloperidol and droperidol , respectively ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
8,
20
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
101,
112
]
} |
the utility of the antiarrhythmic drug procainamide ( pa ) is limited by the required dosage schedule ( every three to four hours ) . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
19,
38
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
39,
51
]
} |
to study the possible mechanisms of the formation of secondary therapeutic resistance , the author carried out a chronic experiment on animals which were administered different doses of a neuroleptic ( haloperidol ) for 20 days . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
188,
199
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
202,
213
]
} |
the antiarrhythmic efficacy and safety of oral tocainide hydrochloride and quinidine sulfate were compared in a double-blind , 3-center , parallel trial involving 133 patients with benign and potentially lethal ventricular arrhythmias . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0034415",
"name": "quinidine sulfate",
"pos": [
75,
92
]
} |
the role that the new antiarrhythmic agents , such as verapamil and amiodarone , might play in the therapeutic strategy of tachycardia-induced fetal heart failure remains to be determined . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
22,
43
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
68,
78
]
} |
the purpose of this study was to examine the mechanisms involved in the uptake of the urinary antibacterial drug trimethoprim by incubated slices of rat renal cortex . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial drug",
"pos": [
94,
112
]
} | {
"id": "C0041041",
"name": "trimethoprim",
"pos": [
113,
125
]
} |
[ determination of the concentration of a new antiarrhythmic , flecainide , in plasma using high pressure liquid chromatography ( hplc ) : sample preparation with extraction columns ] . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
46,
60
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
63,
73
]
} |
eighteen patients with huntington 's chorea were examined before and after neuroleptic treatment ( haloperidol , pimozide , tiapride ) to study the effect of such treatment on hyperkinesia and motor performance . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
75,
86
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
99,
110
]
} |
eighteen patients with huntington 's chorea were examined before and after neuroleptic treatment ( haloperidol , pimozide , tiapride ) to study the effect of such treatment on hyperkinesia and motor performance . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
75,
86
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
113,
121
]
} |
1- [ 2,5-dichloro-6- [ 1- ( 1h-imidazol-1-yl ) -ethenyl ] phenoxy ] -3- [ ( 1-methylethyl ) amino ] -2-propanol hydrochloride ( 48 ) ( 711389-s ) was selected as a candidate for clinical evaluation in man , since its antiarrhythmic effects were superior to those of quinidine , disopyramide , or propranolol . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
217,
231
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
266,
275
]
} |
1- [ 2,5-dichloro-6- [ 1- ( 1h-imidazol-1-yl ) -ethenyl ] phenoxy ] -3- [ ( 1-methylethyl ) amino ] -2-propanol hydrochloride ( 48 ) ( 711389-s ) was selected as a candidate for clinical evaluation in man , since its antiarrhythmic effects were superior to those of quinidine , disopyramide , or propranolol . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
217,
231
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
278,
290
]
} |
[ antibiotic therapy : use and clinical evaluation of a new antibacterial drug , ceftazidime ( rg 159 ) administered parenterally in children ] . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
60,
73
]
} | {
"id": "C0007559",
"name": "ceftazidime",
"pos": [
81,
92
]
} |
in contrast , the agonist-induced asymmetric and circling behaviours of electrolesioned rats were some 9-44 times more sensitive than those of 6-ohda lesioned rats to antagonism by the neuroleptic agents haloperidol , alpha-flupenthixol and oxiperomide , although tiapride antagonism was very similar in both the electro... | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic agents",
"pos": [
185,
203
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
204,
215
]
} |
the effects of a new antiarrhythmic compound , sun 1165 ( which resembles lidocaine in chemical structure ) on sodium currents ( ina ) of enzymatically isolated , single rat ventricle cells were studied under current or voltage clamp conditions . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
21,
35
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
74,
83
]
} |
the presently reported findings : that spaced electroconvulsive treatment increases the density of alpha-1 adrenoceptor in the spinal cord as well as in the cerebral cortex of the rat , that treatment with various classes of antidepressant drugs , including antidepressant neuroleptics , affects in a similar manner alph... | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
225,
239
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
461,
471
]
} |
neuroleptics such as the thioxanthene , cis ( z ) -flupentixol , the phenothiazine , fluphenazine , the butyrophenone , haloperidol and the benzamide clebopride are equipotent behaviourally as well as clinically . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
0,
12
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
120,
131
]
} |
prolonged , 21-days treatment with some antidepressant ( imipramine , nomifensin and mianserin ) markedly reduced the response of the type i inhibitor activity to isoprenaline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
40,
54
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
57,
67
]
} |
sigma opiates and certain antipsychotic drugs mutually inhibit ( + ) - [ 3h ] skf 10,047 and [ 3h ] haloperidol binding in guinea pig brain membranes . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic drugs",
"pos": [
26,
45
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
100,
111
]
} |
some antipsychotic drugs inhibited ( + ) - [ 3h ] skf 10,047 binding with high to moderate affinities in the following order of potency : haloperidol greater than perphenazine greater than fluphenazine greater than acetophenazine greater than trifluoperazine greater than molindone greater than or equal to pimozide grea... | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic drugs",
"pos": [
5,
24
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
138,
149
]
} |
some antipsychotic drugs inhibited ( + ) - [ 3h ] skf 10,047 binding with high to moderate affinities in the following order of potency : haloperidol greater than perphenazine greater than fluphenazine greater than acetophenazine greater than trifluoperazine greater than molindone greater than or equal to pimozide grea... | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic drugs",
"pos": [
5,
24
]
} | {
"id": "C0026388",
"name": "molindone",
"pos": [
272,
281
]
} |
some antipsychotic drugs inhibited ( + ) - [ 3h ] skf 10,047 binding with high to moderate affinities in the following order of potency : haloperidol greater than perphenazine greater than fluphenazine greater than acetophenazine greater than trifluoperazine greater than molindone greater than or equal to pimozide grea... | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic drugs",
"pos": [
5,
24
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
307,
315
]
} |
the data appear to be consistent with the hypothesis that the antidepressant action of desipramine is mediated by alpha 2-autoreceptor desensitization . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
62,
76
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
87,
98
]
} |
to determine the optimal schemes of rational antibacterial therapy of pyelonephritis gravidarum with ampicillin and cephuroxim , assays of the patient urine and studies on the pharmacokinetics of the drugs were performed . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
45,
58
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
101,
111
]
} |
new micromethod to study the effect of antimicrobial agents on toxoplasma gondii : comparison of sulfadoxine and sulfadiazine individually and in combination with pyrimethamine and study of clindamycin , metronidazole , and cyclosporin a . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
39,
59
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
204,
217
]
} |
masked controlled rabbit studies were done to determine the toxic effects on corneal wound healing of the antiviral ointments 0.5 % idoxuridine , 3 % ara a , and 3 % acyclovir , and the antiviral drops 0.1 % idoxuridine , 3 % ara amp , and 1 % trifluridine . | therapeutic_class_of | {
"id": "C0003451",
"name": "antiviral",
"pos": [
106,
115
]
} | {
"id": "C0040987",
"name": "trifluridine",
"pos": [
244,
256
]
} |
these antimicrobials were the bactericidal aminoglycoside antibiotics , streptomycin , gentamicin and kanamycin , the bacteriostatic protein synthesis inhibitors , chloramphenicol and chlortetracycline and the antifungals , 5-fluorocytosine , nystatin and amphotericin b . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungals",
"pos": [
210,
221
]
} | {
"id": "C0016278",
"name": "5-fluorocytosine",
"pos": [
224,
240
]
} |
these antimicrobials were the bactericidal aminoglycoside antibiotics , streptomycin , gentamicin and kanamycin , the bacteriostatic protein synthesis inhibitors , chloramphenicol and chlortetracycline and the antifungals , 5-fluorocytosine , nystatin and amphotericin b . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungals",
"pos": [
210,
221
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
256,
270
]
} |
this compares with a value of 1.35 x 10 ( -2 ) micrograms ml-1 for the standard antimalarial , chloroquine . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarial",
"pos": [
80,
92
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
95,
106
]
} |
these data lead to the conclusion that cibenzoline has the characteristics of class i and some class iv anti-arrhythmic action , but cibenzoline is not another quinidine because it would not appear to influence outward potassium current . | therapeutic_class_of | {
"id": "C0003195",
"name": "anti-arrhythmic",
"pos": [
104,
119
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
160,
169
]
} |
zetidoline ( ztd ) , a compound chemically unrelated to any available antipsychotic , with selective dopamine receptor-blocking properties , was compared with haloperidol ( hlp ) in a double-blind study on 56 in-patients who had either first episodes or acute relapses of schizophrenia . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic",
"pos": [
70,
83
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
159,
170
]
} |
there was significant improvement in all treatment groups except those treated with antiseptic lavage using pvp-i and noxythiolin . | therapeutic_class_of | {
"id": "C0003205",
"name": "antiseptic",
"pos": [
84,
94
]
} | {
"id": "C0032857",
"name": "pvp-i",
"pos": [
108,
113
]
} |
a prospective controlled trial on the use of 1 month 's antimicrobial therapy in patients with relapse of crohn 's disease revealed that metronidazole was associated with a 57 % response rate , compared with a response of only 17 % in patients receiving no metronidazole . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
56,
69
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
257,
270
]
} |
twenty-one patients whose severe ventricular arrhythmias were not controlled by other currently used antiarrhythmic agents or who were intolerant of those drugs were treated with a new antiarrhythmic agent , propafenone . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
101,
121
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
208,
219
]
} |
the efficacy of a new antiarrhythmic agent , lorcainide , was compared with that of quinidine gluconate in a fixed-dose , randomized , crossover trial . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
22,
42
]
} | {
"id": "C0072869",
"name": "quinidine gluconate",
"pos": [
84,
103
]
} |
the antiarrhythmic efficacy of mexiletine in acute myocardial infarction ( ami ) was studied in 99 patients randomized to mexiletine or placebo treatment . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
122,
132
]
} |
the antibacterial potency of 250 mg/kg of amikacin is comparable to that of 100 mg/kg of hydroxygentamicin . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
42,
50
]
} |
it was concluded that fluoxetine provides effective antidepressant activity with fewer and less troublesome side effects than imipramine . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
52,
66
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
126,
136
]
} |
an increased prescription of dmard was found at a national level ( sweden ) , starting with chloroquine , followed by penicillamine and finally by gold . | therapeutic_class_of | {
"id": "C0003191",
"name": "dmard",
"pos": [
29,
34
]
} | {
"id": "C0030817",
"name": "penicillamine",
"pos": [
118,
131
]
} |
since this metabolite is equipotent to nt in inhibiting neuronal noradrenaline uptake , it is suggested that it might be of clinical value as an antidepressant by virtue of having less anticholinergic side-effects than nt itself . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
145,
159
]
} | {
"id": "C0028420",
"name": "nt",
"pos": [
219,
221
]
} |
the discriminative stimulus effects of cocaine ( 3.0 mg/kg ) were attenuated in a dose-related manner by the neuroleptic haloperidol ( dose range tested : 0.1-1.0 mg/kg ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
109,
120
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
121,
132
]
} |
a multicenter clinical trial of 274 patients compared the efficacy and safety of a new vaginal antifungal compound , butoconazole nitrate cream 2 % ( butoconazole ) , to clotrimazole vaginal tablets 200 mg/day ( clotrimazole ) . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal",
"pos": [
95,
105
]
} | {
"id": "C0107509",
"name": "butoconazole nitrate",
"pos": [
117,
137
]
} |
these results suggest that vft in anaesthetized cats is markedly increased by beta-adrenoceptor blockade and only marginally increased by the direct class iii antiarrhythmic action of d-sotalol . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
159,
173
]
} | {
"id": "C0037707",
"name": "sotalol",
"pos": [
186,
193
]
} |
effects of three class i antiarrhythmic drugs ( quinidine , lidocaine , and prajmaline ) on transmembrane resting ( rmp ) and action potentials ( ap ) of isolated rabbit atrial and ventricular myocardium were studied at different stimulation rates . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
25,
39
]
} | {
"id": "C0034414",
"name": "quinidine",
"pos": [
48,
57
]
} |
effects of three class i antiarrhythmic drugs ( quinidine , lidocaine , and prajmaline ) on transmembrane resting ( rmp ) and action potentials ( ap ) of isolated rabbit atrial and ventricular myocardium were studied at different stimulation rates . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
25,
39
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
60,
69
]
} |
the mean ( +/- sd ) antiarrhythmic unbound serum concentration range of s ( + ) -disopyramide was 0.55 +/- 0.31-0.90 +/- 0.81 mg/l . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
20,
34
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
81,
93
]
} |
the data suggest that the antiarrhythmic activity associated with racemic disopyramide resides in the s ( + ) enantiomer . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
26,
40
]
} | {
"id": "C0012702",
"name": "disopyramide",
"pos": [
74,
86
]
} |
continuous-wave doppler measurements of ascending aortic blood flow velocity were obtained in 16 patients while not receiving antiarrhythmic drugs on 2 consecutive days to assess day-to-day variability , as well as while receiving maximally tolerated oral doses of mexiletine ( 11 patients ) and propafenone ( 9 patients... | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
126,
146
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
296,
307
]
} |
in conclusion , although the three type i antiarrhythmic agents tested may all adversely affect left ventricular function in patients with heart failure , encainide and tocainide are more likely than procainamide to cause hemodynamic and clinical deterioration . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic agents",
"pos": [
42,
63
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
200,
212
]
} |
a case of acute urinary retention , presumably secondary to the use of the antiarrhythmic drug flecainide , is presented . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
75,
94
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
95,
105
]
} |
to shorten the latency-to-response time for antidepressant treatment , three patients diagnosed with major depression were treated simultaneously with lithium and nortriptyline . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
44,
58
]
} | {
"id": "C0028420",
"name": "nortriptyline",
"pos": [
163,
176
]
} |
class iii antiarrhythmic action linked with positive inotropy : acute electrophysiological and inotropic effects of amiodarone in vitro . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
10,
24
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
116,
126
]
} |
the antidepressants , imipramine-like ( imipramine , chlorimipramine , desipramine , metapramine and amitriptyline ) and non-imipraminic ( minaprine , maprotiline , viloxazine , mianserin , fluvoxamine and indalpine ) , and the 3 noted above , had potentially convulsive effects . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
4,
19
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
58,
68
]
} |
the antidepressants , imipramine-like ( imipramine , chlorimipramine , desipramine , metapramine and amitriptyline ) and non-imipraminic ( minaprine , maprotiline , viloxazine , mianserin , fluvoxamine and indalpine ) , and the 3 noted above , had potentially convulsive effects . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
4,
19
]
} | {
"id": "C0009010",
"name": "chlorimipramine",
"pos": [
53,
68
]
} |
the antidepressants , imipramine-like ( imipramine , chlorimipramine , desipramine , metapramine and amitriptyline ) and non-imipraminic ( minaprine , maprotiline , viloxazine , mianserin , fluvoxamine and indalpine ) , and the 3 noted above , had potentially convulsive effects . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
4,
19
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
71,
82
]
} |
the antidepressants , imipramine-like ( imipramine , chlorimipramine , desipramine , metapramine and amitriptyline ) and non-imipraminic ( minaprine , maprotiline , viloxazine , mianserin , fluvoxamine and indalpine ) , and the 3 noted above , had potentially convulsive effects . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
4,
19
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
101,
114
]
} |
in the latter two models , da depletion in the prefrontal cortex did not modify the antidepressant effects of desipramine ( 32 mg/kg and 24 mg/kg/day , respectively ) . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
84,
98
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
110,
121
]
} |
the antifungal agent amphotericin b ( amb ) holds interesting immunomodulating properties and its n-thiopropionyl derivative ( ambsh ) is a potent polyclonal b-cell activator . | therapeutic_class_of | {
"id": "C0003308",
"name": "antifungal agent",
"pos": [
4,
20
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
21,
35
]
} |
further , this antimicrobial efficacy was greatly increased in a silicone gel sheet that contained 0.02 % of oflx and an additional 10 % of silicone oil . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
15,
28
]
} | {
"id": "C0028902",
"name": "oflx",
"pos": [
109,
113
]
} |
other antidepressant agents -- notably amitriptyline -- are known to ameliorate postherpetic neuralgia , but those agents are often toxic . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant agents",
"pos": [
6,
27
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
39,
52
]
} |
however , in addition to its role as an antidepressant , attention is being focused on the use of clomipramine in 2 other areas of psychiatry : obsessive compulsive disorder and panic disorder . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
40,
54
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
98,
110
]
} |
the actions of the antiepileptic drugs phenytoin , carbamazepine and phenobarbitone , and the local anaesthetic drugs lignocaine and procaine on sodium-dependent and calcium-dependent compound action potentials ( na- and ca-spikes ) have been compared in rat preganglionic cervical sympathetic nerves , using extracellul... | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
19,
38
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
39,
48
]
} |
the possibility that neuroleptic-induced dopamine d2 receptor supersensitivity involves an alteration in brain iron content was investigated in nutritionally iron-deficient and control rats chronically treated with haloperidol ( 5 mg/kg daily for 14 or 21 days ) . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
21,
32
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
215,
226
]
} |
the neuroleptic drug haloperidol , a d2 receptor antagonist , was found to produce a rapid and transient induction of c-fos mrna expression as compared with the expression in animals treated with saline . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
4,
15
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
21,
32
]
} |
in conclusion , the classical antipsychotic drug , haloperidol , clearly decreases dopamine turnover in nigrostriatal and mesolimbic dopaminergic systems . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic drug",
"pos": [
30,
48
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
51,
62
]
} |
the effects of post-trial administration of amineptine , a dopaminergic antidepressant drug , were compared with those of memory-facilitating ( strychnine , piracetam ) or impairing drugs ( phenobarbital , imipramine ) on an experimental model of memory . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant drug",
"pos": [
72,
91
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
206,
216
]
} |
increases in rat striatal preproenkephalin mrna levels following chronic treatment with the depot neuroleptic , haloperidol decanoate . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
98,
109
]
} | {
"id": "C0062103",
"name": "haloperidol decanoate",
"pos": [
112,
133
]
} |
therefore , as a result of the increasing utilization of depot neuroleptics therapeutically , we examined the effects of haloperidol decanoate on striatal preproenkephalin mrna levels . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
63,
75
]
} | {
"id": "C0062103",
"name": "haloperidol decanoate",
"pos": [
121,
142
]
} |
the acute administration of cyclic antidepressant drugs ( 2.5 mg/kg , i.v . ) resulted in different mydriatic effects ( amitriptyline greater than protriptyline approximately imipramine greater than clomipramine greater than nortriptyline greater than desipramine approximately maprotiline ) which were attenuated ( 17-5... | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
35,
49
]
} | {
"id": "C0002600",
"name": "amitriptyline",
"pos": [
120,
133
]
} |
the acute administration of cyclic antidepressant drugs ( 2.5 mg/kg , i.v . ) resulted in different mydriatic effects ( amitriptyline greater than protriptyline approximately imipramine greater than clomipramine greater than nortriptyline greater than desipramine approximately maprotiline ) which were attenuated ( 17-5... | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
35,
49
]
} | {
"id": "C0033743",
"name": "protriptyline",
"pos": [
147,
160
]
} |
the acute administration of cyclic antidepressant drugs ( 2.5 mg/kg , i.v . ) resulted in different mydriatic effects ( amitriptyline greater than protriptyline approximately imipramine greater than clomipramine greater than nortriptyline greater than desipramine approximately maprotiline ) which were attenuated ( 17-5... | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
35,
49
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
175,
185
]
} |
the acute administration of cyclic antidepressant drugs ( 2.5 mg/kg , i.v . ) resulted in different mydriatic effects ( amitriptyline greater than protriptyline approximately imipramine greater than clomipramine greater than nortriptyline greater than desipramine approximately maprotiline ) which were attenuated ( 17-5... | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
35,
49
]
} | {
"id": "C0009010",
"name": "clomipramine",
"pos": [
199,
211
]
} |
the acute administration of cyclic antidepressant drugs ( 2.5 mg/kg , i.v . ) resulted in different mydriatic effects ( amitriptyline greater than protriptyline approximately imipramine greater than clomipramine greater than nortriptyline greater than desipramine approximately maprotiline ) which were attenuated ( 17-5... | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
35,
49
]
} | {
"id": "C0028420",
"name": "nortriptyline",
"pos": [
225,
238
]
} |
the acute administration of cyclic antidepressant drugs ( 2.5 mg/kg , i.v . ) resulted in different mydriatic effects ( amitriptyline greater than protriptyline approximately imipramine greater than clomipramine greater than nortriptyline greater than desipramine approximately maprotiline ) which were attenuated ( 17-5... | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
35,
49
]
} | {
"id": "C0011685",
"name": "desipramine",
"pos": [
252,
263
]
} |
resistance of p. falciparum to other anti-malaria drugs , e.g. , chloroquine and pyrimethamine , did not affect susceptibility of its asexual and sexual stages to qinghaosu . | therapeutic_class_of | {
"id": "C0003374",
"name": "anti-malaria",
"pos": [
37,
49
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
65,
76
]
} |
porcine taenia solium cysticercosis , recognized as a model of the human disease , was used to analyze the effect of the anthelminthic drug praziquantel on hosts and parasites . | therapeutic_class_of | {
"id": "C0003158",
"name": "anthelminthic",
"pos": [
121,
134
]
} | {
"id": "C0032911",
"name": "praziquantel",
"pos": [
140,
152
]
} |
the potency of the classical neuroleptic haloperidol ( 0.03-0.25 mg/kg ip ) to antagonize apomorphine-induced hypermotility was reduced in 6-ohda-pretreated rats . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
29,
40
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
41,
52
]
} |
perphenazine was discontinued after the fourth episode of priapism and antipsychotic treatment with thiothixene was subsequently initiated . | therapeutic_class_of | {
"id": "C0040615",
"name": "antipsychotic",
"pos": [
71,
84
]
} | {
"id": "C0039955",
"name": "thiothixene",
"pos": [
100,
111
]
} |
differences in epms rates between the two most frequently used neuroleptics , haloperidol , a high-potency butyrophenone , and perazine , a medium-potency phenothiazine , were distinct . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptics",
"pos": [
63,
75
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
78,
89
]
} |
the antiarrhythmic agent lidocaine ( 20 microm ) inhibits current flow through the channel in a voltage-dependent fashion . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
4,
18
]
} | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
25,
34
]
} |
the antimicrobial agent used was erythromycin in one case , amoxicillin in one case , and a third generation cephalosporin in two cases . | therapeutic_class_of | {
"id": "C1136254",
"name": "antimicrobial agent",
"pos": [
4,
23
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
33,
45
]
} |
effect of the antiepileptic drug sodium valproate on glutamine and glutamate metabolism in isolated human kidney tubules . | therapeutic_class_of | {
"id": "C0003299",
"name": "antiepileptic",
"pos": [
14,
27
]
} | {
"id": "C0037567",
"name": "sodium valproate",
"pos": [
33,
49
]
} |
three such compounds , an antihistamine ( tripelennamine ) , a neuroleptic ( haloperidol ) , and an anxiolytic ( oxazepam ) were examined for their behavioral and neuroendocrine effects . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
63,
74
]
} | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
77,
88
]
} |
[ therapeutic experiences in the treatment of hyperkineses with the neuroleptic pimozide ( antalon , orap ) in the frame of huntington chorea ] . | therapeutic_class_of | {
"id": "C0040615",
"name": "neuroleptic",
"pos": [
68,
79
]
} | {
"id": "C0031935",
"name": "pimozide",
"pos": [
80,
88
]
} |
because cimetidine can inhibit the cytochrome p450 mixed-function oxidase system , we believe it could decrease the production of the hepatotoxic acetaminophen metabolite ( s ) providing an effective antidote to be used in conjunction with acetylcysteine . | therapeutic_class_of | {
"id": "C0003295",
"name": "antidote",
"pos": [
200,
208
]
} | {
"id": "C0001047",
"name": "acetylcysteine",
"pos": [
240,
254
]
} |
[ comparative study of the effect of the antimalarials dabequin and chloroquine on retinal ultrastructure in the rat ] . | therapeutic_class_of | {
"id": "C0003374",
"name": "antimalarials",
"pos": [
41,
54
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
68,
79
]
} |
[ antiarrhythmic efficacy of mexiletine , propafenone and flecainide in ventricular premature beats . a comparative study in patients after myocardial infarction ( author 's transl ) ] . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
2,
16
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
29,
39
]
} |
[ antiarrhythmic efficacy of mexiletine , propafenone and flecainide in ventricular premature beats . a comparative study in patients after myocardial infarction ( author 's transl ) ] . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
2,
16
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
42,
53
]
} |
[ antiarrhythmic efficacy of mexiletine , propafenone and flecainide in ventricular premature beats . a comparative study in patients after myocardial infarction ( author 's transl ) ] . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
2,
16
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
58,
68
]
} |
in 12 patients with coronary artery disease , 11 of them with previous myocardial infarction , the antiarrhythmic effects of orally administered flecainide ( f. ) , mexiletine ( m. ) and propafenone ( p. ) were examined . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
99,
113
]
} | {
"id": "C0016229",
"name": "flecainide",
"pos": [
145,
155
]
} |
in 12 patients with coronary artery disease , 11 of them with previous myocardial infarction , the antiarrhythmic effects of orally administered flecainide ( f. ) , mexiletine ( m. ) and propafenone ( p. ) were examined . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
99,
113
]
} | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
165,
175
]
} |
in 12 patients with coronary artery disease , 11 of them with previous myocardial infarction , the antiarrhythmic effects of orally administered flecainide ( f. ) , mexiletine ( m. ) and propafenone ( p. ) were examined . | therapeutic_class_of | {
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
99,
113
]
} | {
"id": "C0033429",
"name": "propafenone",
"pos": [
187,
198
]
} |
cardiovascular and antidepressant effects of imipramine in the treatment of secondary depression in patients with ischemic heart disease . | therapeutic_class_of | {
"id": "C0003289",
"name": "antidepressant",
"pos": [
19,
33
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
45,
55
]
} |
11 antibacterial drugs , i. e. tobramycin , sisomicin , gentamicin , amicacin , neomycin , carbenicillin , polymyxin m , erythromycin , tetracycline , rifampicin and dioxidine proved to be most active against acinetobacter calcoaceticus . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
3,
16
]
} | {
"id": "C0040341",
"name": "tobramycin",
"pos": [
31,
41
]
} |
11 antibacterial drugs , i. e. tobramycin , sisomicin , gentamicin , amicacin , neomycin , carbenicillin , polymyxin m , erythromycin , tetracycline , rifampicin and dioxidine proved to be most active against acinetobacter calcoaceticus . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
3,
16
]
} | {
"id": "C0027603",
"name": "neomycin",
"pos": [
80,
88
]
} |
11 antibacterial drugs , i. e. tobramycin , sisomicin , gentamicin , amicacin , neomycin , carbenicillin , polymyxin m , erythromycin , tetracycline , rifampicin and dioxidine proved to be most active against acinetobacter calcoaceticus . | therapeutic_class_of | {
"id": "C0279516",
"name": "antibacterial",
"pos": [
3,
16
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
91,
104
]
} |
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