text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the results suggest that this lower ifn-gamma production in ms may be secondary to the disease , and the primary defect may be a severe reduction of the essential lymphocyte populations required for an effective lymphokine cascade to produce the normal immune response against infection . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
163,
173
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
212,
222
]
} |
human t lymphocytes stimulated by mitogens ( pha , cona or pwm ) , anti-tcr/cd3 monoclonal antibodies or allogeneic leucocytes express this 26 kda antigen after 2-4 hours . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocytes",
"pos": [
6,
19
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
72,
75
]
} |
following acute k repletion in vivo leading to complete normalization of muscle k content , the incorporation of [ 3h ] leucine into muscle protein showed no increase within 2 h , but reached 76 and 104 % of the control level within 24 and 72 h respectively . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
73,
79
]
} | {
"id": "C0026832",
"name": "muscle protein",
"pos": [
133,
147
]
} |
the inhibitory effect of erythrocyte suspensions and haemoglobin solutions on the response of the bovine retractor penis muscle ( brp ) and the rat anococcygeus to field stimulation of their non-adrenergic non-cholinergic ( nanc ) nerves has been compared . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
25,
36
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
53,
64
]
} |
although it has been suggested that this stimulatory effect may be mediated via an action on hypothalamic crf-41 release , direct measurements have not previously been made . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
93,
105
]
} | {
"id": "C0010132",
"name": "crf-41",
"pos": [
106,
112
]
} |
t cells expressing either the alpha beta or gamma delta antigen receptor ( tcr ) are distinct cell lineages . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
0,
7
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
75,
78
]
} |
2 ) the alpha 2-adrenergic blockade causes suppression of the release of hypothalamic grf and enhanced release of endogenous somatostatin , thereby suppressing gh secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
73,
85
]
} | {
"id": "C0023610",
"name": "grf",
"pos": [
86,
89
]
} |
2 ) the alpha 2-adrenergic blockade causes suppression of the release of hypothalamic grf and enhanced release of endogenous somatostatin , thereby suppressing gh secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
73,
85
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
125,
137
]
} |
while these gender-associated differences may represent effects of the gonadal hormones directly on the somatotrope , they could reflect modulation of the secretion of hypothalamic srif and/or ghrh by the prevailing gonadal hormone environment . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
168,
180
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
181,
185
]
} |
the leukocyte integrins lfa-1 , cr3 and p150,95 are a family of heterodimeric receptors that mediate divalent cation-dependent cellular adhesion reactions . | tissue_is_expression_site_of_gene_product | {
"id": "C0023516",
"name": "leukocyte",
"pos": [
4,
13
]
} | {
"id": "C0079785",
"name": "cr3",
"pos": [
32,
35
]
} |
the cd3-epsilon enhancer did not display sequence similarity with the t cell-specific enhancer of cd3-delta , a related gene co-regulated with cd3-epsilon during intrathymic differentiation . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
70,
76
]
} | {
"id": "C0759310",
"name": "cd3-epsilon",
"pos": [
143,
154
]
} |
we conclude that the monoclonal antibody tg 158 detects an epitope which is present in thyroid tissue-derived tg but not in circulating thyroglobulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
87,
94
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
136,
149
]
} |
these results indicated that t cell hybridomas recognized the conformational change of class i molecule resulting from the exchange of the alpha 3 domain via their t cell receptors . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
29,
35
]
} | {
"id": "C0034790",
"name": "t cell receptors",
"pos": [
164,
180
]
} |
acrylamide gel electrophoretic analysis of adenohypophyseal sth and lth in androgenized male and female rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "adenohypophyseal",
"pos": [
43,
59
]
} | {
"id": "C0033371",
"name": "lth",
"pos": [
68,
71
]
} |
[ erythrocyte carbonic anhydrases of men and some animals . 5. hemoglobin and carbonic anhydrase of primates , chimpanzees ( pan troglodytes ) and cynomolgus ( macaca irus ) ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
2,
13
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
63,
73
]
} |
concentrations of glucose 6-phosphate and 6-phosphogluconate were studied in islets of langerhans isolated from rat pancreas and incubated in the presence of various agents that induce insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islets of langerhans",
"pos": [
77,
97
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
185,
192
]
} |
[ contribution to the cytological study of the anterior lobe of the pituitary of the adult non-lactating castrated rat after parturition and treated with luteotrophic hormone ( lth ) ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "of",
"pos": [
40,
42
]
} | {
"id": "C0033371",
"name": "luteotrophic hormone",
"pos": [
154,
174
]
} |
mechanism of myocardial protection during blood-potassium cardioplegia : a comparison of crystalloid red cell and methemoglobin solutions . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
101,
109
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
114,
127
]
} |
differential diagnosis between hypothalamic and pituitary hgh deficiency with the aid of synthetic gh-rh 1-44 . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
31,
43
]
} | {
"id": "C0037668",
"name": "gh-rh 1-44",
"pos": [
99,
109
]
} |
increased hypothalamic gnrh secretion appears to influence positively the number of pituitary gnrh receptors ( gnrh-r ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
10,
22
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
111,
115
]
} |
gnrh also increases serum lh and gnrh-r in hypothalamus-lesioned rats , and these animals injected with exogenous gnrh are , therefore , a good model in which to study the site of steroid feedback at the pituitary level . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
43,
55
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
114,
118
]
} |
for the anterior pituitary gland , the prolactin , tsh , gh , lh and fsh contents in male nar were significantly lower than those of normal rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "anterior pituitary gland",
"pos": [
8,
32
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
39,
48
]
} |
the comparison of thallium scans with plasma thyroglobulin levels showed certain differences ( high plasma thyroglobulin without any proof of remaining thyroid tissue in one patient and normal/low plasma thyroglobulin in the presence of a tumour in two patients ) but both measurements could give additional information ... | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
152,
159
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
204,
217
]
} |
secondly , the use of the color of hemoglobin itself to identify mixed colonies prevents the detection of those colonies where the erythrocytic component is small or contains relatively little hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocytic",
"pos": [
131,
143
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
193,
203
]
} |
extracts of both rat hypothalamus and pancreas were analyzed for their corticotropin releasing factor ( crf ) -like immunoreactivity by radioimmunoassay ( ria ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
21,
33
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
104,
107
]
} |
in the case of the hypothalamus , besides the rat crf , further identified by high-pressure liquid chromatography ( hplc ) , two peptide components , a 20-kda and a 10-kda species were detected . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
19,
31
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
50,
53
]
} |
isolation of t-lymphocyte lines with specificity for islet cell antigens from spontaneously diabetic ( insulin-dependent ) rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cell",
"pos": [
53,
63
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
103,
110
]
} |
thus , raised basal growth hormone levels in diabetes and the fall that follows intensive insulin treatment may reflect changes in hypothalamic regulation of , rather than in pituitary responsiveness to , grf . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
131,
143
]
} | {
"id": "C0037668",
"name": "grf",
"pos": [
205,
208
]
} |
we used a cloned human cdna probe homologous to the placenta chorionic gonadotropin beta subunit ( cgb ) and to the pituitary luteinizing hormone beta subunit ( lhb ) and southern blotting techniques to analyse dna from a series of rodent x human somatic cell hybrids for the presence of specific gonadotropin beta subun... | tissue_is_expression_site_of_gene_product | {
"id": "C0032043",
"name": "placenta",
"pos": [
52,
60
]
} | {
"id": "C0106132",
"name": "chorionic",
"pos": [
61,
70
]
} |
kinetics of thymidine entry into tonsillar lymphocytes and its alteration in the presence of a lymphokine . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
43,
54
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
95,
105
]
} |
these agents may interfere with critical lymphocyte - macrophage interactions ( lymphokine/monokine synthesis and/or secretion ) that are required for intact suppressor responses . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
41,
51
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
80,
90
]
} |
the method was based upon an assumption that intravenously injected anti-cea is not accessible to normal epithelial cells , since the tight junction will act as a barrier for the diffusion of antibodies from the interstitium to the apical cell surface , but the anti-cea will form immunecomplexes with the cea on the bas... | tissue_is_expression_site_of_gene_product | {
"id": "C0014597",
"name": "epithelial cells",
"pos": [
105,
121
]
} | {
"id": "C0007082",
"name": "cea",
"pos": [
306,
309
]
} |
modulation by recombinant dna leukocyte ( alpha ) and fibroblast ( beta ) interferons of the expression and shedding of hla- and tumor-associated antigens by human melanoma cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
54,
64
]
} | {
"id": "C0015980",
"name": "beta",
"pos": [
67,
71
]
} |
the ability of this method to detect specific binding of soluble ia with antigen activated t cells makes it a useful tool for studying interaction of membrane free major histocompatibility complex ( mhc ) products with native t cell receptor . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
91,
98
]
} | {
"id": "C0034790",
"name": "t cell receptor",
"pos": [
226,
241
]
} |
incubation of rat fibroblasts ( rfa-1 ) with theophylline after newcastle disease virus ( ndv ) induction , increased rat fibroblast interferon ( rfifn ) yields 3 to 10-fold . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
18,
29
]
} | {
"id": "C0015980",
"name": "fibroblast interferon",
"pos": [
122,
143
]
} |
they also suggest that although a possible augmentation of the hypothalamic lhrh release at the preovulatory phase can not be denied , a series of endocrine events during the human menstrual cycle may be regulated by the feedback action of the ovarian signals on the pituitary under a fixed input of the hypothalamic lhr... | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
63,
75
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
317,
321
]
} |
pituitary glands of grassfrog ( rana pipiens ) , bullfrog ( rana catesbeiana ) , clawed toad ( xenopus laevis ) and two species of terrapin ( chrysemys picta and pseudemys scripta ) were incubated in medium containing hypothalamic extract ( he ) , thyrotrophin releasing hormone ( trh ) , somatostatin , dopamine , or co... | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
218,
230
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
289,
301
]
} |
our results demonstrate that basal and k+-induced somatostatin release from rat hypothalamic fragments are modulated by local glucose concentrations , and this effect is specific as it is not paralleled by lhrh changes . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
80,
92
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
206,
210
]
} |
human hypothalamic grf shows major homologies ( 93 % , 89 % , and 86 % , respectively ) when its primary structure is compared to that of the hypothalamic grf from the porcine , bovine , caprine , and ovine species . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
6,
18
]
} | {
"id": "C0037668",
"name": "grf",
"pos": [
155,
158
]
} |
prostatic primary lesions contained pap and psa in 13 ( 81 % ) and 12 ( 75 % ) cases , respectively . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostatic",
"pos": [
0,
9
]
} | {
"id": "C0138741",
"name": "psa",
"pos": [
44,
47
]
} |
oral supplementation of five patients with 50 mg pyridoxine twice daily for 2 months resulted in increased plasma and erythrocyte plp levels and a slight , but not significant , increase in erythrocyte cell number , hb , concentration , and hematocrit . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
118,
129
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
216,
218
]
} |
the ratio of the age-related enzyme , erythrocyte glutamic oxaloacetic transferase ( egot ) , to hemoglobin ( hb ) increased progressively through the fractions , suggesting a correlation between erythrocyte volume and age . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
38,
49
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
97,
107
]
} |
a similar relationship of egot to hb was observed to that in the human subpopulations . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "egot",
"pos": [
26,
30
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
34,
36
]
} |
isolated acini from normal mice , which have accompanying islets of langerhans , were studied under conditions where endogenous insulin was minimized . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islets of langerhans",
"pos": [
58,
78
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
128,
135
]
} |
in view of cell distribution differences in mammalian islets of ventral and dorsal primordia , we have determined the percentage volumes of insulin- , glucagon- , and somatostatin-containing cells in primary and secondary catfish islets to ascertain if these islets correlated with those derived from ventral and dorsal ... | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "cell",
"pos": [
11,
15
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
140,
147
]
} |
eight choriocarcinomas and two immature placentas were stained with a polyclonal rabbit anti-beta-human chorionic gonadotropin ( beta-hcg ) , a monoclonal mouse hybridoma anti-beta-hcg ( moab1 ) , and a monoclonal mouse hybridoma antibody that recognizes only a free beta-hcg chain ( moab2 ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0032043",
"name": "placentas",
"pos": [
40,
49
]
} | {
"id": "C0106132",
"name": "beta-hcg",
"pos": [
267,
275
]
} |
a two fold stimulation in the incorporation of [ 3h-methyl ] groups from [ 3h-methyl ] methionine into phospholipids was seen in intact pancreatic islets within six minutes of exposure to a glucose concentration that stimulates insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
136,
153
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
228,
235
]
} |
distribution dynamics of oxygen tension throughout the erythrocyte volume was calculated by means of a mathematical model describing the dynamics of oxygen transport in the erythrocyte , its shape , diffusion resistance of hemoglobin solution . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
55,
66
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
223,
233
]
} |
differences in serum concentrations , in vitro synthesis by liver slices , and cell-free translational activity of total tissue rna for alpha-fetoprotein and albumin were determined at days 40 , 60 , and 80 of gestation and in newborn pigs . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
60,
65
]
} | {
"id": "C0002210",
"name": "alpha-fetoprotein",
"pos": [
136,
153
]
} |
investigation of the effects of injecting monoamines ( noradrenaline , dopamine and serotonin ) into the third ventricle of the brain on the lh-rh content in the synaptosomal fraction of the mediobasal hypothalamus in intact and castrated male rats has demonstrated that all the three monoamines are involved in the regu... | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
202,
214
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
389,
394
]
} |
to examine the role of t-cell subsets in the development of thyroid lesions , female cba/j mice were immunized with 60 micrograms mouse thyroglobulin ( mtg ) in 0.1 ml complete freund 's adjuvant in both hind footpads . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
60,
67
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
136,
149
]
} |
in vitro , poorly iodinated thyroglobulin ( tg ) is hydrolysed at the same rate whether it is enclosed in thyroid or in liver lysosomes , while fully iodinated tg is degraded faster inside liver lysosomes . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
106,
113
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
160,
162
]
} |
after in vivo tsh administration , thyroid lysosomes hydrolyse fully iodinated tg as fast as do liver lysosomes . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
35,
42
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
79,
81
]
} |
studies performed in the homogenized thyroid tissues indicated that these goitrous glands had pronounced decrease of immunoreactive thyroglobulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
37,
44
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
132,
145
]
} |
these findings suggest that antigen-specific and mitogen-induced t cell triggering are due to interaction with the same receptors of the t lymphocyte . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
65,
71
]
} | {
"id": "C0034790",
"name": "receptors",
"pos": [
120,
129
]
} |
the modification of isolated pancreatic rat islets by pretreatment with alpha-glucosidase abolished the stimulatory action of phentolamine but not changed glucose induced insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic",
"pos": [
29,
39
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
171,
178
]
} |
neuraminidase-treated rbc which contained normal amounts of hemoglobin and rbc ghosts which were hemoglobin-free were used . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
22,
25
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
97,
107
]
} |
whether cultured rat schwann cells synthesize the basement membrane-specific components , laminin and collagen type iv , and whether these components influence the adhesion , morphology , and growth of these cells have been investigated . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
50,
67
]
} | {
"id": "C0009333",
"name": "collagen type iv",
"pos": [
102,
118
]
} |
more importantly , the hemoglobin effect on spectrin self-association is demonstrable at physiological hemoglobin concentration , ph , and osmolarity , suggesting that in intact red cells the spectrin dimer-dimer association , as well as the membrane skeletal structure , is strengthened by intracellular hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
178,
187
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
305,
315
]
} |
however , the possibility exists that extravascular fibronectin accumulation may be only secondary to interstitial fibrin clot formation , and that blood vessel-associated fibronectin may be only a function of adsorption onto basement membrane ( type iv ) collagen . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement",
"pos": [
226,
234
]
} | {
"id": "C0009333",
"name": "type iv",
"pos": [
246,
253
]
} |
the metabolic situation found in pancreatic islets exposed to both l-glutamine and 2-ketoisocaproate was investigated in order to assess its relevance to the synergistic effects of these nutrients upon insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
33,
50
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
202,
209
]
} |
from these results the author is of the opinion , that in the ewe , principally aha , but not mbh , retains the ability to produce lhrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "mbh",
"pos": [
94,
97
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
131,
135
]
} |
the antibody inhibits the antiviral activity of human fibroblast interferon in an antiviral assay using human fs4 fibroblast , reacts immunologically with interferon-beta separated by sodium dodecylsulfate/polyacrylamide gel electrophoresis and subsequent transfer to nitrocellulose and absorbs interferon-beta immunolog... | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
54,
64
]
} | {
"id": "C0015980",
"name": "interferon-beta",
"pos": [
295,
310
]
} |
because the viscosity of the erythrocyte interior and the kinetics of gelation are dependent on the concentration of hemoglobin , we postulated that cetiedil might inhibit sickling by modifying erythrocyte sodium or potassium movements in a manner that would increase cell water content and thus dilute the cell hemoglob... | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
29,
40
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
312,
322
]
} |
at intervals , thyroid weight , dna , iodine and thyroglobulin content , thyroglobulin iodination , and intracellular droplet formation were measured . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
15,
22
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
73,
86
]
} |
it inhibits srbc rosette formation of peripheral t cells and appears to be an erythrocyte receptor of peripheral t cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
49,
56
]
} | {
"id": "C0034790",
"name": "receptor",
"pos": [
90,
98
]
} |
the distribution of red blood cell g6pd phenotype was studied by means of the methemoglobin elution test in newborn ( 46 ) and adult ( 50 ) gdmediterranean heterozygous females and newborn ( 20 ) and adult ( 30 ) hemizygous males . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
20,
34
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
78,
91
]
} |
treatment of human fibroblast cells with human fibroblast ( beta ) interferon for up to 8 hr resulted in the accumulation of at least four mrnas . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
19,
29
]
} | {
"id": "C0015980",
"name": "beta ) interferon",
"pos": [
60,
77
]
} |
a new hypothalamic substance , and not luteinizing hormone-releasing hormone , is detected immunocytochemically by antibody to luteinizing hormone-releasing hormone . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
6,
18
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing",
"pos": [
127,
156
]
} |
adjacent paraffin sections of rat hypothalami fixed in bouin 's fluid were treated either with buffer or with luteinizing hormone-releasing hormone ( lhrh ) before immunocytochemical staining with anti-lhrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
34,
45
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing hormone",
"pos": [
110,
147
]
} |
this idea was confirmed by the isolation by high-pressure liquid chromatography of a peak , distinct from lhrh , upon treatment of hypothalami with lhrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
131,
142
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
148,
152
]
} |
the release of heparin binding peptides from platelet thrombospondin by proteolytic action of thrombin , plasmin and trypsin . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
45,
53
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
54,
68
]
} |
our results therefore suggest that , in cultured thyroid cells from human non-toxic goitre , tsh induces a resting state of the cells , characterized by reduced growth , reduced protein synthesis and reduced thyroglobulin hydrolysis . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
49,
56
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
208,
221
]
} |
the lysosomal activity or the various experimental groups was determined by measuring the activity of beta-glycerophosphatase and cathepsin d both in thyroid homogenates and in semipurified thyroid lysosomal preparations , and the degradation of labelled thyroglobulin by the various lysosomal fractions . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
150,
157
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
255,
268
]
} |
the results suggest that thyroid lysosomal activity may participate in the autoregulation of thyroid secretion by inducing synthesis of new enzymes and modulating thyroglobulin degradation . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
25,
32
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
163,
176
]
} |
fixation of erythrocytic anions ( chlorine and 2,3 diphosphoglycerate ) modulate certain intrinsic properties , allowing the hb molecule to provide for efficacious transport of oxygen between the environment and the metabolically active tissues . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocytic",
"pos": [
12,
24
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
125,
127
]
} |
the investigations were directed to determining whether dehydration was accompanied by : a ) a shortened red blood cell survival , b ) altered sensitivity of the erythropoietin ( ep ) -producing mechanism , c ) a shortened red blood cell transit time , d ) changes in the ep serum half-life , e ) changes in hemoglobin p... | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
105,
119
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
308,
318
]
} |
the bm components consisted of acid-extracted type iv collagen , pepsin fragments of collagen type iv , laminin , and fibronectin . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "bm",
"pos": [
4,
6
]
} | {
"id": "C0009333",
"name": "collagen type iv",
"pos": [
85,
101
]
} |
the effects of gh on the release of somatostatin from the hypothalamus were assessed by measuring the concentrations of immunoreactive somatostatin ( irs ) in hypophysial portal blood of urethane-anesthetized male rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
58,
70
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
135,
147
]
} |
the latter is under the synergistic influence of the pituitary gonadotropins , follicle stimulating hormone ( fsh ) , and luteinizing hormone ( lh ) , the secretion of which is , in turn , stimulated by the hypothalamic decapeptide , lh-releasing hormone ( lh-rh ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
207,
219
]
} | {
"id": "C0023610",
"name": "lh-releasing hormone",
"pos": [
234,
254
]
} |
in pre-pubertal period ( 5-7 weeks of age ) , camp responses of hypothalamus and pituitary to gonadotropin or lhrh were significant , whereas responses of adrenal and ovary were slight and not significant . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
64,
76
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
110,
114
]
} |
it was found that both supernatant and particulate fractions from male rat hypothalami rapidly inactivated somatostatin and that the enzymes involved have an optimum ph of 7.3 . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
75,
86
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
107,
119
]
} |
isolated pancreatic islets were used to determine whether substances of hypothalamic origin could directly influence the release of insulin and glucagon . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
9,
26
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
132,
139
]
} |
these results suggest that stimulation of the release and synthesis of gh mediated by the hypothalamic grf fraction is under influence of the pool size of incubation media . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
90,
102
]
} | {
"id": "C0023610",
"name": "grf",
"pos": [
103,
106
]
} |
although the addition of 1 microng/ml of idm alone resulted in no effect on the basal release of these hormones , idm diminished the release of acth induced by crude rat hypothalamic extracts ( he ) or lysine-8-vasopressin ( lvp ) , and lh induced by he or luteinizing hormone-releasing hormone ( lh-rh ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "he",
"pos": [
10,
12
]
} | {
"id": "C0023610",
"name": "luteinizing",
"pos": [
257,
268
]
} |
since the latter could not be due to contaminating non-t cells , this activity was ascribed to fc receptor-bearing t lymphocytes . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
55,
62
]
} | {
"id": "C0034790",
"name": "receptor",
"pos": [
98,
106
]
} |
when the canine thyroid gland was stained by immunofluorescence and immunoperoxidase methods using undiluted thyroglobulin antiserum , a considerably stronger immunoreactivity was revealed in the parafollicular cells than in the colloid droplets and follicular cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid gland",
"pos": [
16,
29
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
109,
122
]
} |
the erythrocyte glycolytic intermediate 2,3-diphosphoglycerate ( dpg ) and adenosine triphosphate ( atp ) play an important role in oxygen transport and delivery by binding to hemoglobin ( hb ) and reducing its affinity for oxygen . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
4,
15
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
176,
186
]
} |
nasal epithelial cells responded equally to both leukocyte and fibroblast if , with development of resistance to virus replication that was time and dose dependent . | tissue_is_expression_site_of_gene_product | {
"id": "C0014597",
"name": "epithelial cells",
"pos": [
6,
22
]
} | {
"id": "C0015980",
"name": "fibroblast if",
"pos": [
63,
76
]
} |
to evaluate whether or not an increased ratio of t ( 3 ) to t ( 4 ) in thyroidal secretion could be contributing to this relative t ( 3 ) hyperproduction , t ( 3 ) , t ( 4 ) , and iodine were measured in thyroglobulin ( tg ) from controls and patients with graves ' disease who had been treated either with propranolol o... | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroidal",
"pos": [
71,
80
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
204,
217
]
} |
pancreatic islet tissue from lean and obese zucker rats was investigated with histologic and immunocytochemical techniques , and the changes in cytologic composition were correlated with levels of serum glucose , lipids , and insulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islet",
"pos": [
0,
16
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
226,
233
]
} |
red cell sod activity showed a progressive fall from 263.1 +/- 30.5 units/mg non-hemoglobin protein ( nhp ) in infants of less than 29 weeks of gestation to 168.9 +/- 21.3 units/mg nhp in infants of more than 36 weeks of gestation ( p less than 0.05 ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
0,
8
]
} | {
"id": "C0019046",
"name": "nhp",
"pos": [
181,
184
]
} |
at the hypothalamus , pge2 may inhibit gh-inhibiting factor ( gif ) release or induce release of gh releasing factor ( ghrf ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
7,
19
]
} | {
"id": "C0037659",
"name": "gh-inhibiting factor",
"pos": [
39,
59
]
} |
at the hypothalamus , pge2 may inhibit gh-inhibiting factor ( gif ) release or induce release of gh releasing factor ( ghrf ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
7,
19
]
} | {
"id": "C0037668",
"name": "gh releasing factor",
"pos": [
97,
116
]
} |
storage of blood in acid-citrate-dextrose ( acd ) solution gradually depletes red cell 2,3-diphosphoglycerate ( dpg ) and increases the affinity of hemoglobin for oxygen . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red",
"pos": [
78,
81
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
148,
158
]
} |
in the judgment of the function of the anterior lobe of the pituitary gland with the help of the dynamics of the hgh-secretion the changes in the pretest-period should be included in order to avoid false diagnoses . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "the",
"pos": [
3,
6
]
} | {
"id": "C3714500",
"name": "hgh",
"pos": [
113,
116
]
} |
temporal changes in the hypothalamic and serum luteinizing hormone-releasing hormone ( lh-rh ) levels and the circulating ovarian steroids during the rat oestrous cycle . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
24,
36
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing",
"pos": [
47,
76
]
} |
inhibition of a-amylase activity in presence of glycogen phosphorylase , as previously observed in muscle extracts , was absent in the system of purified enzymes , but was restored by addition of proteins of the muscle extract , particularly proteins of the mitochondrial fraction which form a complex with glycogen . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
99,
105
]
} | {
"id": "C0026832",
"name": "proteins",
"pos": [
242,
250
]
} |
red cell and haemoglobin values in 44 women with a typical picutre of anorexia nervosa showed that 20.5 % presented a picture of true anaemia . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
0,
8
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
13,
24
]
} |
the results obtained indicate that t cells do not carry or produce an excess of a1 compared to l-chain , as would have been expected if the t cell antigen receptor carried the same variable region as the ig heavy chain while being otherwise composed of nonimmunoglobulin-like structures . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
35,
42
]
} | {
"id": "C0034790",
"name": "t cell antigen receptor",
"pos": [
140,
163
]
} |
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