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Senior Bioinformatician . Conduct end to end analyses of large scale data driven problems , consisting of independent research , data exploration , pipelining and visualisation , leading to actionable conclusions . Lead the design and implementation of in house packages in Python and R that are used in production and include unit tests and version control with git . Represent the bioinformatics team in cross company meetings for Microbiotica s culture collection program Communicate complex methods , analyses and results effectively in an interdisciplinary environment . . Technologies :
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Researcher . I work as a researcher at the Department of Immunology , crystallizing a target protein involved in human health . . I 'm an experienced structural biologist focusing on the molecular basis of human disease , with a broad repertoire of methods . Key skills : X ray crystallography Protein expression and purification Membrane proteins Lipidic cubic phase crystallisation LCP Drug development Microbiology Molecular biology Surface plasmon resonance Cell biology Microbiology Antibodies Immunology Science communication . Technologies : Xray;SPR
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antibodies;membrane proteins;expression;interaction;structure
|
Senior Bioinformatics Scientist . . Experienced computational biologist with a demonstrated history of working in the biotechnology industry . Skilled in prokaryotic eukaryotic genomics , statistical data analysis and molecular biology . Strong research professional with a Doctor of Philosophy Ph.D. focused in Genomic Sciences Genomics from University of Liverpool . . Technologies :
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Pre Doctoral Fellow . Detailed studies on organelle dynamics and effected metabolite pathways in gene knockout knockdown parasite will throw light on organelle associated cellular homeostasis pathways in the malaria parasite . Overall our studies will also help us to validate these candidates as new drug targets in the parasite . Expertise in culturing and subculturing adherent mammalian cell lines , transfection , cell counting , cryopreservation of cell lines . Efficient in cultivation of Plasmodium falciparum parasite cell culture and cell based immunological assay development , generation and maintenance of stable transgenic lines Molecular cloning and gene expression Experienced in protein biology purification , antibody generation , immunoblotting and Co immunoprecipitation Trained in SPR and Confocal microscopy Proficiency in training and managing laboratory technician and students Lab management and part of organizing committees of workshops and symposia Digitals skills : Microsoft office package , photoshop , ImageJ . I am an enthusiastic , hard working and dedicated individual with a strong interest in Cell Biology . Skilled research fellow with good experience of working in the biotechnology industry . Highly experienced in Mammalian Cell Culture , Parasite Cell Culture as well as Bacterial Cell Culture , Protein Expression and Purification , Immunoprecipitation , Fluorescence Microscopy , Surface Plasmon Resonance . Resilient and focused research professional with good work experience .. Technologies : SPR
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Postdoctoral Scholar Fellow . . Study on structures of pathogens and immune related molecules using single particles cryo EM .. Technologies : CryoEM
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proteins;structure
|
Senior computational biologist . Lead design and development of computational systems for bioinformatics analysis of sequence and protein structure for applications in bio defense . . It is my goal to apply my extensive background and training in biological research , computer science , and computational systems development and modeling to address the antibiotic resistance crisis . Specialties : pathogen biology , bioinformatics , biological modeling , protein structural informatics , technical writing and editing , team leadership https : www.researchgate.net profile Carol Zhou ev hdr xprf . Technologies :
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Principle Scientist . Multi project research on developing and characterizing novel protein and RNA based vaccines . 15 years of research experience in fundamental biomedical research : biochemistry , biophysics and molecular biology , rational improvement of specificity of gene editing technology , fundamental research in broad areas of cell biology and immunology , innate DNA repair machinery and retro virology , antigen antibody interactions , structural and stability investigation of antigens , R D of novel analytical assays . Research excellence substantiated by 23 high impact factor publications and recognized through numerous professional awards .. Technologies :
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antibodies;proteins;characterization;interaction;screening
|
Cryo EM Facility Manager . . Julio Ortiz began his career in electron microscopy , under the supervision of Dr. Ra l Padr n at the Venezuelan Institute for Scientific Research IVIC . He moved to Germany where he applied cryo electron microscopy to actomyosin complexes supervised by Dr. Rasmus Schroeder in the Department of Dr. Ken Holmes Max Plank Institute for Medical Research . Turning his attention to tomography and associated techniques , Julio Ortiz went to the Max Planck Institute of Biochemistry in Martinsried for his post doctoral studies in the Dept . of Dr. Wolfgang Baumeister . He contributed to the development of an approach that proved one can obtain meaningful macromolecular structures by classifying and averaging subtomograms essentially moving single particle analysis from 2D to 3D. He presented the first ribosomal atlas of an intact cell S. melliferum . Ortiz and coworkers revealed the native 3D organization of polysomes and solved the structure of hibernating ribosomes inside intact bacterial cells . His expertise covers a broad range of techniques in cryo electron microscopy , from single particle analysis to focused ion beam micromachinery for cellular tomography . After having served at the Netherlands Centre for Electron Nanoscopy NeCEN and the Institute of Genetics and of Molecular and Cellular Biology IGBMC , and the Forschungszentrum J lich as Cryo EM facility manager , he joined Thermo Fisher Scientific as Sr . Software Product Marketing Manager .. Technologies : CryoEM
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proteins;structure
|
Postdoctoral Researcher . My current research focuses on the development of novel late stage C H functionalization methods to streamline the synthesis of PROTACs PROteolysis TArgeting Chimeras , using automatized HTE techniques . This work is supervised by Magnus Johansson , Johan Johansson and Stig Friis , in collaboration with Prof. Lutz Ackermann at the University of G ttingen Germany . . ORCID ID : https : orcid.org 0000 0002 9232 1236 . In 2020 , I obtained a PhD in Organic Chemistry from Imperial College London , where I worked on the Pd catalysed C sp3 H arylation of saturated N heterocycles . I am currently a Postdoctoral Fellow at AstraZeneca Sweden focusing on late stage C H functionalization strategies for PROTACs synthesis . Outside of the lab , I am passionate about travelling and reading ; I enjoy running and , of course , cooking .. Technologies :
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molecular glues;developing;screening
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Research Scientist Small molecule screening for cancer drug development . . My research expertise has spanned diverse areas in biochemistry , biophysics , molecular evolution , and cancer immunotherapy . Pursuing scientific research has been enriching in several ways as in addition to science , it has trained me in project people management , public speaking , and scientific writing . Before starting my research career , I graduated with an engineering degree in food technology . During this course , I was trained in food chemistry , food microbiology , and food processing engineering . For my future career , I am seeking permanent positions as an R D scientist in the areas of protein biophysics biochemistry and science writer or editorial positions . Transferable skills : Project management People management Time management Conflict resolution Mentoring Grant Writing Science Communication Technical expertise : Protein Purification Molecular cloning Enzyme kinetics Circular dichroism spectrophotometry NMR spectroscopy MALDI mass spectrometry Isothermal Titration Calorimetry ITC Biolayer Interferometry BLI Microscale Thermophoresis MST Dynamic Light Scattering DLS SELEX Yeast surface display Instruments used : GE AKTA Basic FPLC and VARIAN RP HPLC systems Spectrophotometers from HITACHI , Applied photosystems and Biokine MALDI TOF TOF mass spectrometer from Bruker Daltonics and Agilent Technologies Bruker Avance NMR spectrometers Auto ITC and PEAQ ITC instruments from GE Octet RED , octet QK and octet Blitz instruments from ForteBio MST instrument from nanotemper , Gryphon robot for preparing crystal screens and ARI UV imager for crystal visualization Data analysis skills : Graph Pad prism and JMP In silico structural and sequence analyses ; spdbv , pymol and ccp4 , BLAST , clustal omega , T Coffee Acquisition and analysis of NMR spectra ; topspin and ccpnmr Solution of cryo EM maps using cryosparc Structure modeling and refinement using COOT and Phenix . Technologies : CryoEM;ITC;SLS DLS;BLI;MST;CD;NMR
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proteins;small molecules;characterization;interaction;screening;structure
|
Senior Research Software Engineer High Performance Computing . . I am a research software engineer for high performance computing for medicine , life and environmental science . Technologies :
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Dean , College of Physical and Mathematical Sciences . The College of Physical and Mathematical Sciences CPMS at Brigham Young University houses seven departments : Chemistry Biochemistry , Computer Science , Geological Sciences , Mathematics , Mathematics Education , Physics Astronomy , and Statistics . Together , we work toward achieving our two fold mission : To provide the environment , the mentors , the tools , and the experiences in fundamental science and mathematics that students all across campus need in order to contribute in their various fields and become lifelong learners . To investigate , understand , and appreciate the beauty and complexity of the universe while enhancing reverence for its Creator . Prospective candidates and students can visit my office at N 181 Eyring Science Center ESC Mon Fri 8 am 5 pm closed for University Devotionals Forums on Tuesdays 11 am 12 pm . You can reach the office by phone at 801 422 2674 or by email at cpms byu.edu . . I m a world class elite scientist , proven scientific leader , and professor of biochemistry who is now serving as the Dean of the College of Physical and Mathematical Sciences at Brigham Young University BYU in Provo , Utah . I earned my doctorate working on electron microscopy of RNA polymerase and other protein complexes with Dr. Roger Kornberg who later won the Nobel prize for structural studies of transcription at Stanford University . I continued my work in protein electron microscopy as a Damon Runyon Walter Winchell post doctoral fellow under the supervision of Dr. Kenneth Downing at the Lawrence Berkeley National Lab . There , my interests expanded to include electron tomography of whole cells . During my 18 year career as Professor of Biology and Biophysics at the California Institute of Technology Caltech , my research focused on three main areas : the ultrastructure of small cells , the structural biology of HIV , and the further development of cryo EM technology . Together with my colleagues , I have published nearly 200 papers in these areas , most in top journals , with over 14 K citations . My lab developed a searchable tomography database and populated it with 50 K cryotomograms of over 100 different viral and microbial samples . Among my most prominent discoveries has been the structure and function of the bacterial type VI secretion system , a poison tipped spring loaded molecular dagger , and the architecture of the type IV pilus responsible for cell motility . All this work is now summarized in a free electronic textbook , the Atlas of Bacterial and Archaeal Cell Structure . In addition to my scientific work , I m passionate about teaching students about biophysical methods and mentoring up and coming scientists . I m best known by students from my popular course , Getting Started in Cryo EM , which has over 1 M hits . To date , 14 scientists I trained have gone on to become professors , and I have two decades of experience leading a lab of 15 20 scientists . In 2020 , I came to BYU to lead the College of Physical and Mathematical Sciences because of my personal faith and commitment to fostering advancement for BYU s students and faculty . I welcome contacts from prospective candidates considering working for the college , students considering BYU and the College of Physical and Mathematical Sciences , and employers interested in our students for internships or future employees . You can reach out to me here on LinkedIn or via email at Grant Jensen byu.edu .. Technologies : CryoEM
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proteins;structure
|
Sr Computational Scientist . GATK methods development . . Technologies :
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RnD Scientist II in Machine Learning , Health Product . . . Technologies :
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Senior Scientist . . Combining strong background in Computational Structural Biology with a cand.scient nanotech and lab training . My interest is in combining experiment and computational simulations to solve challenges in biotech . I enjoy all aspects of science communication as well as taking the lead in challenging projects .. Technologies :
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Principal Scientist . . Committed researcher and teamplayer with a solid foundation as a mass spectrometrist and an interest in digital transformation . I have a problem focused and critical mindset and enjoy solving a challenging problem in a team . I am a skilled communicator of complex scientific results to different stakeholders , and a good multi tasker that can organize and supervise project teams to excel in a short timeframe . In recent years , I have developed my expertise within digitalization by applying data science to repetitive or laborious work tasks . During my career in pharmaceutical sciences , I have worked on and managed a wide variety of research projects both in industry and academia , amongst others : LC MS bioanalysis for early PK PD and ADME studies from plasma and tissue immunogenicity assessment of novel drug candidates by MHC associated peptide proteomics cardiac shot gun proteomics to discover new disease mechanisms affinity proteomics to identify drug targets in the brain structure activity relationship studies of protein peptide interactions using HDX MS . Technologies : SPR
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Postdoctoral Scholar . Investigating structure property relationships for solid lipid nanoparticles LNPs with applications in gene therapy in Sahay lab Characterizing lipid membrane properties using thermal analysis , small angle X ray scattering , electron microscopy , and fluorescent assays Heading cryo electron microscopy efforts , including generating funds via grants 30k , image acquisition , processing , and 3D reconstruction Extensive experience in scientific writing paper , grants , and reviews . Analytical Chemist with broad experience in Organic , Materials , Colloidal , Polymer , and Biological chemistry . Self motivated researcher with excellent problem solving and critical thinking skills equally experienced working with a team both as a member and a supervisor .. Technologies : Xray;CryoEM
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carriers;characterization;stability;structure
|
Sr . Laboratory Director . Applying cryo EM to antibody epitope mapping from vaccine trials , including HIV . Protein biochemist and structural biologist in the field of HIV vaccine design . Duties include design and expression of novel immunogens in mammalian cells , stringent purification protocols for animal immunization studies , and quality control assessment of antigens alone or in presence of adjuvants buffers using a combination of biolayer interferometry , differential scanning calorimetry , isothermal titration calorimetry , and electron microscopy . Assessment includes samples from GMP level production . Additional projects involve high resolution epitope mapping and structural determination of HIV Env trimers using cryoelectron microscopy , with a focus on trimer dynamics . https : www.ncbi.nlm.nih.gov myncbi 1LypwukJvMUQ7 bibliography public . Technologies : CryoEM;ITC;DSC;BLI
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antibodies;characterization;interaction;stability;structure
|
Associate Director , Bioinformatics . . I am a Bioinformatics PhD with experience analyzing a variety of next generation sequencing to answer different biological questions . Sequencing has the potential to greatly advance human health and this goal comes with many challenges that I am eager to solve . Although I have a deep love for biology , I am broadly interested in the development and application of computational and statistical methods that extract meaningful information from large scale data sets . All interesting problems are welcome .. Technologies :
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Research Scholar . Working on the elucidation of the high resolution structure of apolipoprotein B 100 by cryo EM . . . Technologies : CryoEM
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proteins;structure
|
Bioinformatics Scientist . Computational biology to study diverse mechanisms of gene regulation . Bioinformatic studies of cell state from single cell high throughput sequencing data . . Experienced at generating discoveries through working in collaborative teams that can include synthetic chemists , virologists , structural biologists and cell biologists . Expert at methods development , computational modeling , machine learning and molecular simulation . Research activities include analysis of high throughput sequencing data or simulations to study drug resistance in infectious disease , gene regulation in cell cycle , cellular differentiation and cancer .. Technologies :
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Computational Biology Senior Software Engineer . . . Technologies :
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Associate Director , Computational Biology . . . Technologies :
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Director of Informatics . Head R D Systems and Data Science . Serving as an Information Technology professional for 20 years across biotechnology and pharmaceutical industries while managing decisions , design , and support of software systems and data science within research , development , pre clinical , and clinical groups . Specialties : Biotechnology Biology Chemistry . Technologies :
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Researcher . Executing and developing cross linking mass spectrometry of protein complexes . Analytical scientist with extensive knowledge in protein mass spectrometry and structural biology , with core expertise in host pathogen interactions and antibody characterization . Key areas of expertise include a unique combination of protein biochemistry , cross linking mass spectrometry and single particle cryoEM . Ambitious , detail oriented and methodical researcher successful in developing and leading research projects and method development . Key roles in experimental research design , implementation , data analysis , data evaluation and supervision . Reliable and collaborative team player with excellent communication and problem solving skills . Academic research interest is to explore structural and molecular level mechanism of host pathogen interactions during an infection , and how pathogens use defined virulence determinants to target central components of the host s immune system . . Technologies :
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antibodies;proteins;interaction;structure
|
Assistant Professor . Structural biology of lysosomal membrane proteins protein complexes by single particle cryoEM cryo electron tomography . I have always been intrigued by the molecular mechanisms that drive cellular function , especially at the membranes . This led me to pursue my doctoral studies at the Max Planck Institute of Molecular Physiology in Dortmund , Germany . Following which I moved to European Molecular Biology Laboratory EMBL , where I worked towards delineating the aforementioned mechanisms in the native cellular context . I am currently heading an independent research group at the Life Sciences Institute , University of Michigan . . Technologies : CryoEM
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membrane proteins;structure
|
Bioinformatician . . . Technologies :
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Scientist , Machine Learning and Computational Biology . . I am presently a Computational Scientist at Tessera Therapeutics where I develop efficient algorithms and accurate machine learning models for Gene Writing and Gene Rewriting . These are a set of new biotechnologies that enables one to write therapeutic messages into the genome to alter genes and cure diseases . Prior to this , I was a graduate student with Prof. Howard Salis at Penn State University , where I trained as a Computational Synthetic Biologist . There , I developed and experimentally verified novel optimization algorithms and predictive models to engineer synthetic genetic parts , systems , and genomes with tailored design and synthesis constraints . During my PhD research , I published several papers in top tier science journals including a first author paper in Nature Biotechnology . In my free time , I enjoy Sci Fi and Horror .. Technologies :
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Principal Scientist . Structural Biology , Protein Crystallography , Drugability Assessments , Hit to Lead Optimization and Lead Optimization , Fragment Screening . . Technologies : Xray
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proteins;small molecules;screening;structure
|
Senior Computational Biologist I . . Seven year experience in cancer genome sequencing data analysis with python , R , and MATLAB . I developed a cancer driver gene identification method that outperformed eight top notch cancer gene identification tools in 3 out of 4 metrics , including a 51 improvement in overlap with the known cancer genes , and a 102 improvement in consistency over the most popular tool . Expertise : 1 . Programming : Proficient in Python ; some experience with MATLAB , R ; basic knowledge of Perl , SQL 2 . Statistics and Machine learning : Parametric and nonparametric statistics ; Probability distribution ; Hypothesis testing ; Regression Linear , Logistic ; Classification KNN , Decision Tree , Random Forest ; Clustering 3 . Domain knowledge : Cancer genetics ; Oncology ; Next Generation Sequencing NGS ; Biochemistry ; Proteomics 4 . Communication : Collaborated with experimental scientists and physicians ; Teaching experience . Technologies :
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Research Intern Wendler lab . Recipient of the DAAD RISE 2022 working to solve the 3D structure of S25DH using cryo EM and optimising carbon coating for self developed EM grids . . Technologies : CryoEM
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proteins;structure
|
Staff Research Scientist . Cryo EM Scientist for EMBL and ESRF . I am expert in single particle electron cryo microscopy cryo EM and structural biology with a deep interdisciplinary scientific background . Currently , I am part of a team running an cryo EM facilty at ESRF and EMBL Grenoble . In the field of structural biology I specialized in cryo EM with a broad experience in different samples , microscopes and image processing tools . I am interested to link the understanding of the molecular machinery of life , and the translation of structural knowledge for pharmaceutical research application and small molecule design . . Technologies : CryoEM
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proteins;small molecules;structure
|
Research Development Scientist . . 12 years experience in Research Development , including 3 years in postdoctoral academic research and 10 years in industrial R D. Worked as Product Owner PO in Life Science 's technologies , As a PO , Developed new Analytical tools Sensorgram Comparison in Biacore T200 platform 21 CFR part 11 SW for Biosimilars characterization by practicing the Scrum Agile methodologies . Experienced in multidisciplinary R D including Organic Chemistry , Polymer chemistry , Antibody conjugation chemistry , Life science s technologies , Biosensors and Nanomaterial s. Experienced in New Product Development process , from feasibility to design transfer to manu facturing . Led the projects by working with various cross functional teams QA , Eng , Mfg . Skilled in Kaizen , Problem solving process , project visual management and risk management . Hands on experience in various instrumentation data analysis : i Chromatography techniques for small organic molecules large bio molecules purification ; ii Antibody binding affinity studies SPR Biacore ITC , iii Structural characterizations NMR , Mass , IR Fluorescence ; iv Nanomaterial s characterizations TGA , AFM Raman . Published 15 articles , 1 book chapter 10 conference proceedings , resulted with citations 500 h index of 12 . Specialities in R D : Organic synthesis , Bio manufacturing technologies , Antibody conjugation , Bio molecular interaction studies , Protein analytical 's , Biosensors , Nanoparticles Graphene chemistry , Polymer Chemistry , Fluorescent probes . Functional Managerial skills : Technical lead , people manager lab manager . Product owner Scrum methodology . Provided trainings to customers , presented product demo in symposiums . NPI process , Six Sigma , Scrum methodology , Kaizen , Problem solving process and Risk management . Supervised master s graduate students in various multidisciplinary research projects .. Technologies : ITC;SPR;NMR
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antibodies;biologics;small molecules;interaction;structure
|
Advanced Screening Scientist . . Creative scientist with 10 years experience in protein biochemistry , structural biology , assay development , high throughput screening , molecular biology , biophysics , and cell biology . Paired with a passion for science I enjoy to tackle scientific problems . This has resulted in several publications that can be accessed through my ResearchGate profile : https : www.researchgate.net profile Tobias Rumpf . Technologies :
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nucleic acids;developing;screening;structure
|
Director and developer of the antibody discovery platform . Developed and direct the antibody discovery platform for the Division of Immunology and Allergy at the Lausanne University Hospital CHUV in Switzerland . Research is focused on discovery of novel neutralizing antibodies to infectious diseases with fully human antibodies isolated from virus specific B cells in post infected or vaccinated donors . The antibody discovery platform combines an in depth experience and knowledge of cellular immunology , development of sensitive high throughput biochemical assays , cell based neutralization assays and virology expertise to discover the rare antibodies with best in class properties . Cryo electron microscopy has been use to determine the structures of our antibody antigen complexes at a molecular level . Anti COVID antibodies P2G3 and P5C3 , reported in Nature Microbiology and Cell Reports , display highly potent neutralizing activity against all SARS COV 2 variants of concern including Omicron BA.1 , BA.1.1 , BA.2 and are more potent than virtually all authorized or clinically advanced anti SARS CoV 2 mAbs . These antibodies bind two distinct epitopes on the viral Spike protein making it much more difficult for the virus to escape both antibodies when used in combination . Apart from identifying antibodies with potent cell culture based neutralization activity , the antibody discovery platform has strong collaborations with different groups throughout Europe for testing anti viral efficacy in animal models . We demonstrated that P2G3 alone confers complete prophylactic protection when administered to monkey prior to infection with SARS CoV 2 Omicron virus . P2G3 used in combination with P5C3 also confers excellent therapeutic efficacy in clearing virus and inhibiting active viral replication of the Omicron variant with administration of the antibody cocktail after infection of the monkeys . . . Technologies : CryoEM
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antibodies;developing;screening;structure
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Bioinformatics Scientist . . Metagenomic analysis using next generation whole genome shotgun sequencing data and computational pipeline development in a Unix environment for bioinformatics applications . Development of a web application as a theoretical model for functional metagenomics analysis and metabolic reconstruction . Upstream process development experience for production of monoclonal antibodies using mammalian expression systems . Biotech operations expertise in microbial fermentation and cell culture , operating bioreactors ranging in size from 250 mL to 200 liters . Link to a list of my publications via Google Scholar list on this profile is incomplete : https : scholar.google.com citations user KygfdVgAAAAJ hl en oi ao Computing skills : Strong proficiency : Perl ; C ; SQL MySQL ; Excel VBA ; bash shell scripting Some proficiency : C ; Java ; R ; Python ; MATLAB Simulink ; Web Development using Perl CGI and HTML templates , Java based applications using Java servlets , JSP , JDBC , JavaScript Other software packages : MS Office Word , Excel , PowerPoint . Technologies :
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Research Fellow . . I am a research fellow at the University of Birmingham , leading a semantic healthcare research group within the Gkoutos lab . I have established my own theme of research surrounding the creation and application of novel algorithms to learn from multi modal and multi contextual biomedical and clinical data . I have an honorary contract at University Hospitals Birmingham and work closely with clinicians at the Queen Elizabeth Hospital to perform research that has direct implications for patient care , such as discovery of rare disease patients unknown to specialist clinics .. Technologies :
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Head of Scientific Computing . Currently , I am leading a team of 11 developers including a few students and STPs working in the areas of applied computing to Radiation Protection , Radiotherapy Physics , Nuclear Medicine Physics and Imaging in general . The team also develop software throughout the wider trust including a few medical devices . App development is prevalent throughout the teams portfolio as well as many projects looking at standardisation throughout healthcare and deep learning AI and decision support systems mainly with medical images . . . Technologies :
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Senior Research Fellow . . Experienced bioinformatician with a focus on high throughput sequencing analysis in medical genomics . Strong publication record as a collaborator with world class research groups in rare diseases , population , and cancer genomics .. Technologies :
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Associate Scientist . . Experienced Biophysicist specializing in Biopharmaceutical Purification Development . Skilled in Chromatography , Protein Biophysical Chemistry , Biochemistry , Bio analytical Characterization , Molecular Biology , Biotechnology , Cell Culture , and Computational Modeling . Strong professional background with a Doctor of Philosophy PhD focused in Biophysics from University of Wisconsin Madison .. Technologies :
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biologics;proteins;characterization
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Professor of Physical Chemistry and Director , Centre for Computational Science . . . Technologies :
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. . Initially trained as a computer scientist , I went on to computational biology and eventually experimental biology as well . Areas of focus have included developing computational and experimental methods for assaying regulatory genomics , host microbiome interactions , bacterial genomics , single cell genomics , spermatogenesis , and now NK cell biology and immunotherapy .. Technologies :
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Analytical Scientist . Analytical Scientist in the Protein Analytical Chemistry PAC team . . Technologies : SPR;NMR
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proteins;characterization
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Associate Product Manager Intern . AI Powered Search for Salesforce B2B Commerce . I am a UC Berkeley senior pursuing a dual degree in Electrical Engineering Computer Science and Business Administration as part of the Management , Entrepreneurship , and Technology M.E.T. program . I am currently looking for 2023 opportunities in product management , machine learning , and computational biology neuroscience . Please feel free to reach me at anacismaru berkeley.edu . Technologies :
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Senior Researcher in Computational Chemistry . Understand through computational approach what molecular properties convey cell permeability , oral bioavailability , and target binding to drugs beyond the rule of 5 space , particularly macrocycles and PROTACs . The computational approach includes Artificial Intelligence , Biomolecular simulations , Ligand and structure based modeling , molecular properties , etc . . Experienced Computational Chemist with a demonstrated history of working in the higher education industry . Skilled in Pharmaceutical Research , Marcocyclic conformational sampling , cell permeability , Cheminformatics , ADME , PROTAC modeling and biomolecular simulations . Strong research professional with a PhD focused in Computational Medicinal Chemistry from K benhavns Universitet .. Technologies :
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Postdoctoral Research Associate . . Following my PhD and postdoctoral positions elucidating the mechanism of the challenging membrane protein , mitochondrial complex I , I began my current position at Domainex as an assay biologist . Here I am utilising a wide wide variety of techniques to generate bespoke assays that drive developments in drug discovery and industrial science . I find assay development a highly stimulating pursuit , requiring me to solve new problems and draw from a wide knowledge and skill base every day . . Technologies : NMR
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membrane proteins;small molecules;developing
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Analytical Project Lead . Global Drug Development Technical Research Development , Oberhaching , Germany . Senior analytical scientist with cross cultural working experience . Experienced in managing global technical projects in late stage biopharmaceutical development , regulatory submissions and network teams . Broad technical expertise in chromatography , mass spectrometry and biotherapeutic protein and vaccine characterization . . Technologies :
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biologics;characterization
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Associate Statistical Scientist . . . Technologies :
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Vice President , Head of Computational Sciences . I lead the Computational Sciences team . Our work spans computational biology , bioinformatics , data science , and software engineering . Our responsibilities include : Developing and validating analysis pipelines for NGS assays to quantify gene editing and detect potential off target effects existing and novel off target assays , RNA seq , WGS , scWGS , etc . Supporting protein and RNA engineering efforts through phylogenetic analysis , structural modeling , protein design , and novel enzyme discovery Using computational approaches including AI ML to select optimal base editing strategies and prioritize therapeutic targets Building a robust cloud infrastructure for scientific computing Developing software to automate data management and data analysis , as well as building and maintaining databases that power Beam 's scientific efforts Supporting lab automation and LIMS development . . Technologies :
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Director Research Fellow . . 20 years of experience in Biopharma R D Versed in drug discovery in the fields of autoimmunity and Oncology , tackling such diverse target classes as GPCR , NHR , cytokines and their receptors Extensively experienced in leading biology teams and cross disciplinary teams to deliver drug candidates Delivered six clinical candidates , both small molecule and biologic based , and enabled over 10 IND filings Served on several clinical development teams and contributed to selecting indications , designing and implementing clinical trials Established facilitated several collaborations with academic institutions , both inside and outside the US , complementing BMS ' capacity in deepening biologic understanding of diseases and targets as well as in elucidating pharmacologic modes of action of clinical candidates Recognized for his scientific accomplishments at BMS as the recipient of a Biology Leadership Award , a Technology Innovation Award , four Innovation Grant awards , and five Triumph Awards Co authored over 40 peer reviewed publications and holds three patents Trained in both Medicine and Research : M.D. Weifang Medical Univ . , China , MS Shanghai Medical Univ . PhD in Microbiology Immunology Univ . of Missouri Columbia , and postdoc Art Weiss ' lab , HHMI , UCSF . Technologies :
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biologics;membrane proteins;proteins;screening
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Principal Scientist Head of Structural Chemistry . Headed the Structural Chemistry team 3 4 FTE s at two sites in support of a large portfolio of drug discovery projects comprising five therapeutic areas . Established various Biophysics methods for compound characterization and validation of target engagement e.g. by SPR , NMR , TSA . Supported all Lead Discovery efforts by implementing quantitative higher throughput assays to study small molecule behavior in solution e.g. aggregation , solubility , target engagement by NMR , DLS , HPLC . Guided the development of novel Biophysical assays focused on enhancing the understanding of the biochemistry of ubiquitin ligases and other related enzymes involved in cellular protein degradation . Assays of interest include both protein ligand and protein protein interaction techniques with focus on screening and validation novel ligands for E3 ligases , PROTACs and molecular glues by NMR , SPR , among other enabling technologies . Elucidated ternary complex formation and related structure function relations for multiple difficult to drug target proteins . Worked closely and collaboratively in multi disciplinary teams of structural and molecular biologists , medicinal chemists , and pharmacologists . Characterized small molecule ligands and degraders using Biophysics for in depth understanding of target engagement , selectivity , and mechanism of action within the induced proximity platform . Demonstrated that biophysical validation increases success of downstream technologies X ray crystallography , cryo EM , cellular assays . Implemented robust processes for high throughput analytical data generation including NMR and LC MS with automated structure verification that led to more efficient in house small molecule library design and enabled rapid QC of externally synthesized molecules . Collaborated closely with screening , compound management and separations groups in validating compound integrity , and gathered analytical data in unified databases in a fully automated fashion . . Experienced drug hunter with 20 years of successful industrial application of structure guided drug design , leading to multiple approved drugs , advanced leads development candidates . Expert in using Biophysics driven lead generation to assist the development of highly efficient drugs for novel targets including protein protein interaction and membrane proteins . Leader of Biophysics efforts within multidisciplinary teams to support early discovery of Targeted Protein Degradation drugs , including the characterization of E3 ubiquitin ligases , and the evaluation of new modalities , such as PROTACS and molecular glue degraders . Key contributor to discovery and development of drug candidates that ultimately received FDA marketing approval , including the first mutant KRAS targeted inhibitor LUMAKRAS sotorasib , multiple precision oncology drugs such as ICLUSIG ponatinib , ALUNBRIG brigatinib , EXKIVITY mobocertinib , drug eluting coronary artery stent EluNIR ridaforolimus and MRI contrast agent VASOVIST gadofosveset . Subject matter expert for molecular structure analysis of small molecules , API , drug substance and product , impurity analysis by NMR and LC MS including on natural products . Author of numerous regulatory documents CMC section supporting IND and NDA filings . Senior level scientific leader with Ph.D. in biophysical chemistry with postdoctoral studies at Columbia University in New York . Highly motivated , team oriented and goal driven group leader with strong publication record . Superior team building , experimental design , execution , analytical , and interpretive abilities . Significant project leadership experience . Managed scientists with special emphasis on teaching , scientific mentoring , and career development .. Technologies : Xray;CryoEM;SLS DLS;SPR;NMR
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molecular glues;small molecules;characterization;developing;screening;structure
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Review Editor in Membrane Physiology and Membrane Biophysics . Department Pharmakologie und Toxikologie , Medizinische Fakult t. Screening and Testing compounds targeting endo lysosomal ion channels with biochemical and cell based assays on primary neurons isolated from LSDs mouse model and on neurons derived from iPSC carrying LSDs mutations generated using CrisprCas9 technology . During my scientific career , I conducted research focused on the discovery of new druggable targets and the development of pharmacological strategies to treat rare genetic diseases by using cell biology approaches and high content imaging technology Opera and Harmony from PerkinElmer . I used automated protocols to transfect cells with siRNA oligonucleotides using the Hamilton Starlet liquid handling station together with various FDA molecule libraries . . Technologies :
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small molecules;interaction;screening
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PhD Candidate , McHugh Lab . Understanding the in vivo biological function of specific long non coding RNA protein complexes , and performing further studies on their structure , folding and binding . Techniques used include : Cell culture , Western and Northern Blot , qPCR , RNA Immunoprecipitation , Sucrose density ultracentrifugation , Fluorescence microscopy and micro patterining , Transmission and Cryo Electron Microscopy . I am a graduate student pursuing a PhD in Biochemistry and Molecular Biophysics at the University of California , San Diego . I am currently advised by Dr. Colleen McHugh and am working in the field of lcnRNA biology .. Technologies : CryoEM;AUC
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nucleic acids;proteins;interaction
|
Biophysicist PhD Candidate Research Scientist HHMI Gilliam Fellow . My work focuses on developing new biophysical techniques to study how force activated ion channels are activated by cell generated forces in live cells and its downstream functions . This imaging based approach provides important insights into the molecular and biophysical mechanisms by which these channels are endogenously activated . My findings have led to a first author publication which was also featured as one of the editor s picks in the 2019 Communication Biology Anniversary collection My research findings , academic accomplishments and a continued commitment towards being a leader in increasing diversity inclusion in the STEM fields led to being awarded the prestigious HHMI Gilliam Fellowship for Advanced Study Identified and cultivated relationships with several collaborating labs and experts within the mechanobiology and bioengineering fields . As a PhD scientist , I have developed extensive expertise in image analysis , computational microscopy and stem cell biophysics which I regularly draw upon throughout my research projects . My experience in biomedical research has led to strong project management and experimental design experience . This can be seen in the effective collaborations that I have developed across multiple institutions . I independently led teams and managed these projects across multiple stages which ultimately has led to several publications currently in submission and under review at high impact journals . I enjoy communicating my science across audiences and am passionate about outreach and working to increase the visibility of Native Americans in STEM . Feel free to connect . Technologies :
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Senior Cryo EM Expert . . I am a structural biologist and strive to understand fundamental molecular process of life . I employ various methods , especially cryo electron microscopy to elucidate structure of biological macromolecules to understand their working , interactions and regulation ; processes that enable life . Technologies : CryoEM
|
proteins;interaction;structure
|
Research Technician . . Experienced and knowledgeable in drug discovery , evaluation and development having worked with both small molecules and biologicals in oncology and more recently in vaccine development Extensive experience in the pharmaceutical industry and in academic research laboratories Presented oral and poster presentations at national and international oncology conferences . Co author of 24 papers including two as first author published in journals including Nature Communications , Cancer Research and Journal of Virology . ORCID iD https : orcid.org 0000 0002 3945 7708 . Technologies :
|
small molecules;developing
|
Principal Scientist . My role in the Synthetic and Medicinal Chemistry Core is to facilitate structure based drug design through techniques of X ray crystallography and CRYO electron microscopy . . . Technologies : Xray;CryoEM
|
proteins;small molecules;structure
|
Associate Bioinformatics Scientist . . I 've gained experience contributing to both academic and industry based software development projects . In prior roles I 've helped make sense of biologically relevant data ; ranging from electronic health records to single cell RNA seq reads . . Technologies :
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Chief Scientific Officer . . Jared is passionate about the development of novel instrumentation and methods for top down proteomics and native mass spectrometry . He graduated from The University of Texas at Austin in 2013 with a Ph.D. in Analytical chemistry under supervision from Prof. Jennifer Brodbelt . During his graduate studies , Jared s efforts were broadly aimed at the development of novel tandem mass spectrometry MS MS methods for proteomics applications . Most notable was his development of 193 nm ultraviolet photodissociation UVPD for top down proteomics . As a postdoctoral researcher at the Pacific Northwest National Laboratory PNNL , Jared became an expert in Fourier transform mass spectrometry FTMS while leading development of a 21 tesla Fourier transform ion cyclotron resonance mass spectrometer FTICR MS . In 2016 , he was promoted to a senior research scientist at PNNL and led efforts to develop and apply novel FTMS instrumentation and methods to top down proteomics and native mass spectrometry . Through industrial collaborators , Jared was introduced to and began collaborating with the team at e MSion , Inc. in 2017 . This fruitful collaboration led to advances in de novo antibody structure characterization and novel approaches to the characterization of native protein complexes . Jared joined e MSion as Chief Scientific Officer in February of 2020 .. Technologies :
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Senior Scientist Scientific data manager . . Diligent and competent professional with rich , cross functional expertise in Pharma IT and Bioinformatics Industry . Currently working with Evotec . Self motivated with result oriented approach , can rapidly identify problems , initiate change and implement effective program in challenging and diverse environment . Posses keen acumen in analyzing and understanding of Pharma and Biotech Industry requirements . Competencies range from Computational Drug discovery and analysis , Pipeline Pilot Platform and protocol development , Chemoinformatics Unix Linux Shell scripting , Computer Programming C C , High Performance Computing , Data base creation Oracle 10 g , interpretation , review and management . Knowledge of Biological tools and techniques . Designing research methods . Composing abstract , summarizing studies , writing research papers . Project lead and Mentoring in training programs . Can assure quality timely delivery in high pressure environment with strict deadlines .. Technologies :
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Senior Research Engineer . . Anthony Anukam is a researcher with special interests in analytical chemistry ; the biochemical and thermochemical conversion of biomass ; sustainable energy and chemicals production from forest based resources , residues , and by products as well as renewable wastes ; biomass pretreatment , fractionation , and characterization using various advanced analytical instruments ; thermal energy systems combustion kinetics and process simulation ; optimization and operation of lab scale bioconversion and biorefinery plants ; and emission measurements from thermal energy systems as well as life cycle and techno economic assessments of biorefinery technologies . As part of his research activities , he operates and interprets data from a variety of cutting edge analytical techniques such as chromatographic techniques GC , LC , HPLC , GPC ; spectroscopic techniques FTIR , Raman , NMR ; thermal techniques TGA , DSC , DTA ; electron microscopy SEM , TEM , Cryo EM ; etc . His research activities also incorporate data analysis with modeling and process simulations of different energy systems . As a certified higher education teacher , Anthony has taught a variety of courses at different higher education institutions in Africa and Europe with diverse cultural backgrounds . Some of the courses he has taught include general chemistry , analytical chemistry , environmental chemistry , physical chemistry , and combustion chemistry .. Technologies : CryoEM;DSC;NMR
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Director , Novartis Leading Scientist , Hit Generation Science . Leading a team of scientists in MedChem , Peptide Discovery , and DNA encoded chemistry for projects across multiple disease areas . Scientific leadership for scouting , implementing and driving new lead generation approaches . . Contribute to strategy vision for hit generation science in the areas of difficult targets , library science encoded library technologies . . MedChem lead for two external research collaborations on multiple targets from various disease areas . Key projects . Establishing and driving peptide discovery platform projects . Leadership of the Novartis Peptidream collaboration driving several research targets . Leading the Novartis Nuevolution collaboration internalizing DNA encoded library technologies . MIT collaboration on segmented flow technology for MedChem . More than 20 years of drug discovery experience in a pharmaceutical company . 10 years of leadership experience at director level building groups and nurturing talents . Strong background in small molecule medicinal chemistry , lead discovery and peptide chemistry . Solid international network in industry and academia and recognized in scientific community . Excellent analytical capabilities and very effective under time deadline pressure . Ability to operate effectively in local global teams and across multiple disease areas . Successful leadership of several external collaborations . Expertise : . Drug Discovery MedChem . DNA encoded libraries ribisomal display technology Peptidream technology . Discovery of leads for difficult targets , e. g. protein protein interaction . Novel approaches to inhibit kinases . Fragment Based Drug Discovery . Flow chemistry platform for MedChem . Peptide medicinal chemistry . Antibody Drug Conjugates ADC . Scout evaluate external technologies . Implemetation of new technologies . Technologies : NMR
|
peptides;proteins;small molecules;interaction;screening
|
Professor of Health Informatics . . The aim of my scientific research is to introduce verifiable process models into complex scientific applications . Provenance data , executable artifacts , and semi structured adaptive workflows are just some of the aspects that share the same theoretic apparatus , and can be connected into multi level process models . This effort spans multiple areas , from process algebras and formal verification , to provenance graphs , and benefits multiple application domains from clinical trials and Electronic Health Record population studies via bioinformatics to business process modelling and organisational workflows . Publications available at : https : sites.google.com site vasacurcin publications . Technologies :
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Senior Scientist Antibody Discovery . . . Technologies :
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Undergraduate Researcher . Leveraged my knowledge of Python to create a program to compare imputed datasets with whole genome sequences to analyze TOPMed imputation panel diversity and accuracy Curated genomic datasets using Plink to filter out single nucleotide polymorphisms to prepare clean datapoints for genome imputation Implemented use of USC s high performance computing cluster to efficiently compile metadata by running scripts , managing data , and sharing results with group members . I am a fourth year student in the undergraduate Quantitative Biology program at USC and have been accepted into the QBIO progressive masters program . I have a specific interest and background in genetics . Through my undergraduate studies and extracurricular activities I have developed and honed my research and programming skills as well as expanded my knowledge of biology . My studies in the Quantitative Biology program have allowed me to explore and understand the field of genetics through computational data analysis and the importance of each singular nucleotide in our DNA . My coursework in upper level QBIO and Computer science classes have been especially helpful in blending the programming skills C , R and Python with the life science classes at the backbone of my studies . I am currently working in Dr. Charleston Chiang s lab at the USC Center for Genetic Epidemiology with a team to analyze the accuracy of genome sequence imputation in populations not heavily represented in reference panels , working directly with the Linux command line to run analyses of sequence datasets . Through various projects and coursework , I have really found a passion for genetics that I am eager to bring into the workforce .. Technologies :
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Professor . . Principal Investigator with strong leadership skills , project management and a solid scientific background . High success rate Troubleshooter Loyal Extensive international network Currently handle 16 different active research projects . Managing a research group of 8 12 persons for 10 years Supervision , project management , data analysis . Ability to ask the right questions , both for initiating projects and for helping others bringing their projects further . Key objectives in LolandLab : Elucidation of structure function relationships in membrane proteins ; assessment of ligand binding sites , identification of protein conformational changes during activity , visualization of protien structure . Research Methods : Biophysics Fluorescence , FRET , tmFRET , x ray crystalization , Hydrogen Deuterium exchange MS , molecular pharmacology and biology , biochemistry , protein expression purification . Received two prestigious awards from the Danish Council for Independent Research : Young Elite Researcher Prize 2005 , Sapere Aude Research Leader award 2012 Published 67 peer reviewed research papers and 1 patent application , including publications in Nature Neuroscience , Nature Communications , Science Advances , PNAS , JACS , Nature Methods , Biol Psych , JCI and 10 papers in Journal of Biological Chemistry . H factor : 24 , 2300 citations . Participated in 30 international conferences ; all with a scientific presentation as invited or selected speaker or with poster presentation . Member of the International Transmembrane Transporter Society executive committee . Board member in Integrative Structural Biology at University of Copenhagen .. Technologies : Xray;FRET
|
membrane proteins;structure;characterization;interaction
|
Researcher . IBPC UPR 9080 CNRS Laboratoire de Biochimie Th orique Modeling Ligand Gated Ion Channels nicotinic , GABA and P2X receptors activation mechanism with homology modeling and normal mode analysis ; Study of the binding of ligands docking ; study of pathological mutations related to epilepsy and myasthenia . . Modeling of protein structure function relationships including allostery . Current focus on the gating mechanism of ligand gated ion channels nicotinic , GABA and P2X receptors . Analysis of the effect of mutations and effect of ligands including drugs . Specialties : Homology Modeling , Docking , Normal Mode Analysis , Molecular Dynamics .. Technologies : Xray;CryoEM
|
membrane proteins;interaction;structure
|
. . I have been involved with various projects that revolve around enzymes involved in antiviral defense systems . My 6 years experience with protein purification , X ray crystallography and UPLC MS have led me to discover novel small molecules and deduce structures of several proteins especially those involved in antiphage and antiviral immune responses . Understanding such defense systems could help design drugs that target viral and antiviral enzymes with better efficacy . My extensive biochemical , kinetic and structural studies on oxygen sensitive enzymes , nucleotidyltransferases , nucleases , NAD hydrolases and others led me to publish my works in a peer reviewed journals . These include our recent work on an antiphage defense systems has been published in Nature Communications . I have previously worked with antiviral Radical SAM enzymes which led me to publish my manuscript in another peer reviewed journal . I am currently working on two more manuscripts that revolves around analyzing higher order protein structures and undergoing training for Cryo TEM which would be useful tool for further structural studies . I am actively seeking opportunities in structural biology and biochemistry . Given my background in X ray crystallography , protein biochemistry and cryo EM along with my ability to troubleshoot critical problems and multitasking , I believe I would be a good fit for the same . I have also been actively involved with teaching undergraduate and graduate students throughout my graduate career .. Technologies : Xray;CryoEM
|
enzymes;small molecules;structure
|
Senior Bioinformatician . Leading the development of a bioinformatics capability within Fera and to provide bioinformatics analysis and support for projects using Next Generation Sequencing technology . Development of methods and approaches for analysing NGS data , in particular for DNA meta barcoding data , and contribution to scientific papers and project reports . I am working within the Detection and Surveillance Technologies Team , which undertakes research on the detection , identification and characterisation of both harmful and beneficial organisms in the agricultural and natural environment . Using state of the art molecular biology techniques , the team develops methods to detect pathogens and profile the diversity of organisms in a wide range of sample types , including plants , food , soil and water , and is at the forefront of adapting these techniques for use in the field . The team also undertakes research on the biology of bacteria , viruses and fungi that pose a risk to agriculture , embracing new and emerging genomic technologies as well as more traditional microbiological skills . . . Technologies :
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Scientific Data Manager . Management of marine scientific data at the UK Polar Data Centre , British Antarctic Survey . Scientific project coordination and data knowledge management , user support and training , research operations support , leveraging interdisciplinary research experience . Specialties : marine environment data , data standards and integration , bioinformatics , genomics , molecular biology . . Technologies :
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Associate Principal Bioinformatician . . I am a believer in the power of big data and am interested in using data science to tackle some of society 's most complicated problems . I am a bioinformatician by training and my primary research interests center on developing models and techniques to effectively leverage large scale genomic data to advance the frontiers of personalized medicine , particularly in oncology . . Technologies :
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Group Leader , Computational Biology . . I currently hold a full time position within the Methods Group in the Data Sciences Platform at the Broad Institute , as well as affiliate status in Michael Talkowski 's lab at Massachusetts General Hospital . I am technical lead of the Genome Analysis Toolkit Structural Variation GATK SV discovery pipeline and supervise an interdisciplinary team of computational biologists , software engineers , and academic trainees across the two institutions . I oversee structural variant call set generation for large scale whole genome sequencing WGS projects including the Genome Aggregation Database gnomAD and All of Us . My responsibilities also include developing scalable and robust tools , machine learning models , and cloud based pipelines for genomic analyses . I previously developed the GATK PathSeq pipeline for pathogen detection and discovery using deep WGS and RNA seq in collaboration with Matthew Meyerson 's lab at Dana Farber .. Technologies :
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Principal Scientist Computational Biology . . I am a creative scientist and engineer with a highly cross disciplinary education and research background , combining systems biology and bioinformatics with synthetic biology , molecular physiology and metabolic engineering . I currently work as a Computational Biologist in the Data Science group at Sonata Therapeutics formerly Inzen where I apply , develop , and biologically interpret NGS omics data analyses e.g. proteomics , RNA Seq to further Drug Discovery Development around Sonata 's platform and programs e.g. in immuno oncology . Previously I worked in the Computational Biology Group of Biogen in support of translational drug discovery in neurodegenerative diseases and biotherapeutic protein manufacturing development . I obtained my PhD in Chemical Biological Engineering from the University of Colorado Boulder where I combined Genetic Genomic tools targeted genome recombineering , Next Gen Sequencing with Systems Biology tools metabolic flux growth kinetics modeling to improve the application and design of directed evolution mutant library selections and obtain superior microbial strains for conversion of cellulosic sugars to bioproducts . Before that I worked in industrial biotechnology across R D departments genetics , bioprocess engineering , bioinformatics group , first as an MS intern and later as an Assistant Bioinformatics Scientist at DSM N.V. Delft , Netherlands . During my 15 years of research experience in biotechnology I have worked behind the computer dry lab as well as at the bench wet lab doing molecular biology on a variety of organisms : from human disease mechanisms and mammalian cell lines at Biogen , Sonata , to E.coli PhD in Colorado , Penicillium DSM and Yeast MS BS at TU Delft . Specific scientific interests in Computational Biology , Genomics , Systems Biology , Multivariate Statistics , Synthetic Biology , Metabolic Engineering , Bioinformatics , Molecular Biology , Drug Discovery and Development , Bioprocess Engineering . General interests in Data Science , Business Development in Biotechnology , Renewable Energy , and Intellectual Property .. Technologies :
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Project Scientist . Member of the Computational Crystallography Initiative http : cci.lbl.gov . Pursuing a career in structural and computational biology . Full publication list : http : cci.lbl.gov publications aaron brewster.html . Technologies :
| null |
Lecturer in Healthcare Sciences . . . Technologies :
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Ph.D. Student in Molecular Life Sciences . . Technical Skills Proficient in Molecular cloning in prokaryotes Lambda red recombineering , CRISPR cas9 genetic engineering Mammalian cell culturing Western Blot , SDS PAGE , agarose gel electrophoresis Fluorescence , confocal microscopy Protein purification IMAC , Size exclusion chromatography DNA , RNA , protein extraction and purification from bacteria , Zebrafish embryos , yeast In vitro transcription and translation PCR colony PCR , RT PCR Bioinformatics : Designing CRISPR targets gene knockout , NGS data analysis Handling Vertebrate Automated Screening Technology Handling zebrafish as a model system Husbandry , Fin amputation , Imaging , genotyping Handling plate reader fluorescence and absorbance Library preparation for next generation sequencing NGS and analyzing NGS data Stopped flow and quench flow Rapid kinetics techniques High Performance Liquid Chromatography HPLC Processing and analyzing small angle X ray scattering data and cryo Electron Microscopy data Circular dichroism CD spectroscopy Familiar with Gas chromatography GC , High performance liquid chromatography . ImageJ , Cell profiler Image analysis . . Operation of liquid handling robot Nimbus , Hamilton Publications : 1 Abdalaal H , Pundir S , Ge X , Sanyal S , N svall J. Collateral Toxicity Limits the Evolution of Bacterial Release Factor 2 toward Total Omnipotence . Mol Biol Evol . 2020 Oct 1;37 10 : 2918 2930 . doi : 10.1093 molbev msaa129 . PMID : 32437534 ; PMCID : PMC7530605 . : shared first author 2 Pundir S , Ge X , Sanyal S. GGQ methylation enhances both speed and accuracy of stop codon recognition by bacterial class I release factors . J Biol Chem . 2021 Jan Jun;296:100681 . doi : 10.1016 j.jbc.2021.100681 . Epub 2021 Apr 20 . PMID : 33887323 ; PMCID : PMC8131318 .. Technologies : Xray;CryoEM;CD
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Scientist . . . Technologies :
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Phyre2 Scientific Advisory Board Memeber . . Having to step back from leading a team of 17 people in a structural biology setting , supporting small molecule drug discovery , due to illness I now spend my time managing projects and writing proposals . I recently aided in the industrialisation of the XChem X ray fragment screening hosted at Diamond Light source for rapid identification of new starting points for drug discovery . This is now a routine process in action . http : www . diamond . ac . uk industry Case Studies Case Study Fragments . html . I am currently a member of the scientific advisory board for the Phyre2 software suite . A system for structure prediction and also mutation analysis . . Technologies : Xray;NMR
|
small molecules;interaction;structure
|
PHD Researcher . Biophysical characterization of biomolecules with solution and solid state NMR , X ray crystallography and Cryo EM . . Technologies : Xray;CryoEM;NMR
|
peptides;characterization;structure
|
Associate Professor . . I am an associate professor and group leader with strong interdisciplinary background in biology , chemistry , biophysics and nanoscience and expertise in investigation of membrane proteins as well as interface of nanomaterials with biological samples . Through my career , I have measured the strong impact and numerous benefits of collaborative projects and networks to bring my research activities at a predominant international position . This has been achieved by building of long term national and international collaborations with both academic and industrial partners My research Group exploits novel nanomaterials for the development of several types of biosensors : 1 in cell biosensors suitable for the fundamental investigation of membrane protein signalling and the establishment of novel generation of cellular assays for drug discovery ; 2 2D and 3D protein arrays suitable for bioanalytics , proteomics and diagnostics . These novel tools are exploited for the investigation of membrane proteins in vitro and in cells . http : nano.ku.dk english research Nanobio martinez group . Technologies :
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membrane proteins;characterization
|
Senior Scientist in CMC Cell Therapy . . Experienced Quality Expert in ATMP with a demonstrated history of working in the pharmaceuticals industry . Knowledge within GMP for Advanced Therapy Medical Products . Skilled in cell biology , in vitro assays , monoclonal antibodies , Identifying mechanism of action of mAb drug candidates , FACS , ELISA , high through put potency and efficacy screening assays and Cancer Research . Strong quality assurance professional and QP delegate with a PhD in Medical science from University of Copenhagen .. Technologies :
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antibodies;quality
|
Principal Scientist . . Extensive experience in computational modeling and simulations , with emphasis in biological systems . Significant experience in computer programming and algorithm development , with a focus on data analysis and visualization tools for computational biology applications . I am a highly motivated scientist with excellent bilingual verbal and written communication skills , the ability to work in a highly collaborative and intellectually challenging environment , and the ability to learn new skills rapidly . I have a strong interest in developing and applying new methods to assist biomedical research through computational data analysis . My goal is to contribute to the design of new treatments for major diseases . Technologies :
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Scientist , Computational Biology . . I am a computational scientist at Immunitas Therapeutics where I apply computational and statistical methods to single cell RNA seq and spatial transcriptomics data in order to discover new immunotherapies for challenging cancers . I received my Ph.D. in computer sciences from the University of Wisconsin Madison in 2019 and then went on to complete a Postdoctoral Fellowship at the Morgridge Institute for Research in Madison , Wisconsin . In my academic life , I researched and developed new computational and statistical methods for extracting the untapped knowledge contained in large , heterogeneous biomedical datasets in order to address outstanding questions in cell biology , human health , and disease .. Technologies :
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Research Engineer at Institut Pasteur . Developing cryo CLEM and in situ cellular Cryo tomography workflow . I am a specialist in cell biology and electron microscopy with a Ph.D. in Microbiology by Federal University of Rio de Janeiro with a post doc in cell biology and ultrastructure of protozoan parasites at the same university using conventional EM and cryo EM sample preparation high pressure freezing and freeze substitution associated with 3D techniques FIB SEM slice and view and tomography serial sectioning . In 2015 I joined the Brazilian Center for Research in Physics CBPF for 10months in a post doc in the intracellular traffic of nanoparticles of iron oxide and nanostructured hydroxyapatite in mammalian cells , using the FIB SEM slice and view and lamellae preparation techniques in a 3D approach . In 2016 I joined the Philippe Bastin group to study Trypanosoma brucei intraflagellar transport using conventional EM , cryo techniques HPF and FS , and 3D approach FIB SEM slice and view and Amira software associated with fluorescence live cell imaging and basic molecular biology and biochemistry techniques . Since 2019 I am a Research Engineer at Institut Pasteur , developing the Cryo CLEM workflow and Cryo Tomography using photopatterning and cryo lamellae preparation for different biological systems . . Technologies : CryoEM
|
structure
|
Senior Scientist . . I m a research scientist with a broad experience in protein biochemistry . During my academic and industry career I ve worked extensively with protein stability , purification , and nanostructure interactions . I always seek to expand my skillset and for the last few years I ve used programming to solve both small , repetitive data handling tasks as well as more advanced data fitting and analysis automation .. Technologies :
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proteins;interaction;stability
|
Senior Research Scientist PROTACs degrader drugs . Cell assay development and profiling of PROTAC protein degraders : Endogenous protein turnover studies proteomics , complex phenotypic readouts imaging , degradation assays . Project scoping in early drug development . . Fascinated by biology and the power of mass spectrometry . Expertise in cell biology , protein biology degradation PROTACs , chemo proteomics , interpretation of complex data as well as pharmaceutical drug development . Enjoying strategic design of cutting edge and collaborative research .. Technologies :
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molecular glues;developing
|
Scientist . Scientist . Next generation synchrotron X ray facilities such as NSLS II will yield data thousands of times more rapidly than existing X ray facilities . To exploit this capability , we must vastly improve the speed and precision of specimen preparation . To this end , I am exploring acoustic droplet ejection ADE technologies to exploit protein crystals for high throughput applications such as fragment based drug discovery and time resolved crystallography .. Technologies : Xray
|
screening;structure
|
Associate Professor of Health Informatics and Computer Science . . . Technologies :
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Sequencing service lab head , Genetics Genomics . . I am a creative interdisciplinary life scientist with extensive experience in molecular cell biology , small molecules discovery and in depth expertise in high throughput sequencing . I am often described as an enthusiastic and efficient person with great integrity who is highly focused on results and innovation to demonstrate technology feasibility and implementation .. Technologies : SPR
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Senior Director , Computational Sciences and Engineering . Lead development of analysis and software engineering for Inscripta 's DNA editing technologies . Includes architecting computational systems , design and development of analytical algorithms and pipelines , software design processes , and team management . . Currently , I lead development of computational systems and analyses for DNA editing technologies at Inscripta . Previously , I developed micro services systems and algorithms to analyze machine metadata from installed Dell EMC products . I have lead and performed bioinformatic analysis , statistical analysis and mathematical modeling of data for fetal diagnostics . I was a faculty member in computer science with research interests in bioinformatics , data mining , text mining and high performance computing . I have a broad computer science background , with experience in human computer interaction , computational algebra , collaborative computing in addition to my research interests . I was involved in SeWHiP , a consortium for building high performance computing infrastructure in Southeast Wisconsin to assist with the research goals of the academic community in the region . Specialties : data science , bioinformatics , data mining , text mining , machine learning , artificial intelligence , statistics , symbolic computation , high performance computing , algorithms Resume : http : craig.jasna struble.net static strublecaresume.pdf . Technologies :
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Associate Director , Bioinformatics Lead . . . Technologies :
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PHD Fellow . PhD Fellow in the group of Professor Thomas Frimurer Computational Chemistry Molecular Pharmacology Group Computational Chemistry Unit Have a look at our platform We are involved in multiple collaborative probe drug discovery projects and are interested in more We specialize in structure and ligand based drug design for GPCRs . https : cbmr.ku.dk researchfacilities ccu . PhD Fellow in Computational Chemistry Molecular Pharmacology at the Frimurer Group , located at the Center For Basic Metabolic Research University of Copenhagen Hi My name is David , I 'm a drug discovery scientist with bench level experience across a variety of chemistry sub fields medicinal chemistry , process chemistry , and chemical biology . My primary background revolves around synthetic organic chemistry , but I am always looking to integrate my skill set into new areas of science and support teams with what I know . I 've had the privilege of working with promising therapeutic discovery modalities such as nuerodegenerative phenotypic screening at Yumanity Therapeutics , novel lab to plant flow chemistry development at Snapdragon Chemistry , as well as exploring cutting edge target ID deconvolution tools in the Chemical Biology Proteomics department at AstraZeneca . Recently , I 've taken great interest in computational approaches to towards life sciences , based on my experience in the Computational Medicinal Chemistry department at AstraZeneca , where I utilized a reinforcement learning based de novo design platform towards the optimization of kinase inhibitors . Most recently , I have begun my PhD at the University of Copenhagen , as a member of the Copenhagen Bioscience Programme . I 'm always on the look out for interesting approaches to drug discovery , please feel free to reach out with your newest publications , reviews , blogs , or where ever else the latest news is being disseminated . Technologies :
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molecular glues;membrane proteins;developing;structure
|
Senior Research Fellow . . . Technologies :
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Senior Scientist Lab Head . X ray crystallography and cryo EM . Publications : https : www.ncbi.nlm.nih.gov pubmed term ulrich 2C alexander . Technologies : Xray;CryoEM
|
structure
|
Expert Scientist on Rotation at gRED . . 20 years of broad and solid hands on experience in Academia , Biotechnology and early late phase Product development and Project Management in the Biotechnology and Pharmaceutical Industry Novartis , ROCHE . Entrepreneurial mindset as demonstrated by co founding of the Anglo Japanese Biotechnology Company IC Vec Ltd. Documented track record in leading cutting edge projects , innovation patents publications 30 and drug development in early and late phase for NCE and NBEs , technology transfer to CRO CMO . Acknowledged expert skills in nucleic acid based medicines siRNA , ASO , mRNA including Lipid Nanoparticle LNP delivery approaches , and advanced analytics for the characterization of macromolecules and LNPs e. g. CLINAM panelist together with experts from Moderna , BioNTech etc . on the future of mRNA based therapeutics , TIDES speaker invitee . Industry recognized innovator NVS Leading Scientist Award and strategic thinker . Excellent soft skills , as demonstrated leadership in a matrix organization to shape next generation nucleic acid based medicines at ROCHE . Analytical thinker with an excellent eye for the essential tasks . Prefers to work in a people oriented , scientific , dynamic and innovative environment . . Technologies :
|
carriers;nucleic acids;characterization
|
Computational Biologist III . . Computational biologist at Calico Labs , developing tools for single cell analysis and regulatory genomics . Ph . D trained in Christina Leslie s at Weill Cornell , developing machine learning models to study complex biological systems . Highlights : Computational Biology : transcription factor binding site prediction , drug sensitivity prediction , single cell RNA ATAC analysis , next generation sequencing analysis . Machine Learning : CNN , generalized linear models , multitask learning , word embedding . My website : https : hy395.github.io . Technologies :
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Scientist Bioinformatics . . . Technologies :
| null |
Research Intern . . My research interests involve the study of biomolecules especially protein protein interactions , lipid membrane interfaces using various computational approaches . I am also interested in bioinformatics , data science , computational structural biology and drug discovery .. Technologies :
| null |
Research Internship . Characterization of translational inhibitors using biochemical techniques and carrying out disome assays for preparing samples in the quest to decipher the mechanism of action using cryo EM . I am interested in structural , biochemical and molecular biology . In my field , I have had the experience to work on disome assays using a bicistronic template in the quest to decipher the precise mechanism of action of drugs . Therefore , in my Masters , I characterized translational inhibitors biochemically , an exciting part of my career in our quest to combat bacterial resistance . I have had the opportunity to conduct collaborative research in Germany , at the University of Hamburg working on drug discovery project to elucidate the mechanism of action of potent inhibitors . Having amassed skills in sucrose gradient fractionation of ribosomes , the experience has broadened my scientific growth in science and utilizing different experimental techniques for cryo EM preparation .. Technologies : CryoEM
|
proteins;small molecules;screening;structure
|
Senior Scientist , Panel Development . . Highly skilled professional with diverse experience in the biotechnology industry . Over 10 years experience in small molecule drug discovery ADME : cell culture techniques , cell based radiolabeled assays , in vitro metabolism , and analysis using HPLC and LC MS MS . Background includes experience with assay development , quality management , ISO certification process and internal auditing , QC methods development , product development , acceptance testing , document control , and design control .. Technologies :
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