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Principal Research Associate . . Biomedical Scientist currently working as Principal Research Associate at Dragonfly Therapeutics . Been 25 years in the pharmaceutical industry , most recent as Principal Technician at LEO pharma and before that as Specialist at Alligator Bioscience in Lund . Main areas are protein characterization HPLC UHPLC , DLS , MALS , CD , ELISA , endotoxin analysis and formulation of proteins . Also some experience of expression and purification of antibodies and compatibility studies for clinical trials .. Technologies : SLS DLS
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antibodies;proteins;characterization;formulation;structure
|
Research Scientist 2 , strain development . . Scientist with over 10 years of experience in research and development . . I have been working on multiple R D projects in a multinational environment , delivering yeast strains with improved metabolic pathway and titers as well as mammalian cell strains with improved antibodies titers . . Strong experience in synthetic biology , metabolic engineering and biochemistry for the synthesis flavors , fragrances and active pharmaceutical ingredients . Skilled in mammalian cell culture for the production of antibodies . . Technologies :
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antibodies;expression
|
Principal Investigator Discovery Molecular Biology . . Highly accomplished structural biologist , protein engineer , and molecular biologist with 28 peer reviewed publications . Created multiple expression libraries for mammalian and bacterial expression of viral and human proteins . Completed three small molecule fragment screening by X ray crystallography campaigns against infectious disease targets . Demonstrated experienced in the vector construction , expression and purification of recombinant proteins , as well as structural biology , enzymology , analytics , directed evolution , assay design and development . Headed a fragment hit to lead development project through strong , concise , and consistent written and oral communication . Enthusiastic and inventive with proven outstanding leadership skills . Technologies : Xray
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proteins;small molecules;engineering;expression;screening;structure
|
Cell and Molecular Biologist . . . Technologies :
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Research Associate , Microbiology . Cultures filamentous fungi from vials of frozen vegetative mycelium on agar plates Streaks new cultures , organizes growing cultures , monitors growth , separates mixed cultures , harvests mycelium once cultures reach maturity , runs genomic DNA extractions . Experienced programmer , handles all lab data manipulation for the Strain Collection team Excel and Python , works closely with software developers on LIMS integration with our biology workflow LifeMine is a drug discovery startup made possible by the recent plummet in the cost of DNA sequencing . We sequence the genomes of a diverse set of fungi , then search their genomes for possible leads for novel medicines . More information about the company , the team , and recent publications are all publicly available at lifeminetx.com . . Research Associate , experienced in many types of molecular biology and microbiology assays . Bachelor 's of Science in Molecular Biology , and a Minor in Mathematics from Binghamton University . Intellectual interests : I love listening to long form podcasts , interviews , audio books , and lectures . Some favorite podcasters authors professors : Tim Ferris , Sam Harris , Rhonda Patrick , Peter Attia , Lex Fridman , Yuval Noah Harari , Bret Weinstein , Sean Carroll , Douglas Hofstadter . Favorite topics : evidenced based health and well being , philosophy of mind , neuroscience , mathematics , machine intelligence , evolutionary biology , ethics , morality , and cutting edge technologies like robotics , synthetic biology , brain computer interface . Hobbies : non dual insight meditation mindfulness , natural language acquisition working hard on Swedish .. Technologies :
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Lecturer in Bioinformatics . . I was graduated as a medical doctor in Russia in 1992 Pavlov State Medical University , St. Petersburg , Bachelor in Medicine as recognized by UK NARIC . For several years I combined clinical work in emergency medicine and in medical oncology . In 1998 I completed a PhD project that studied sources of oestrogen in breast cancer patients Petrov Institute of Oncology , St. Petersburg , Russia . After PhD , supported by the Royal Society , I went for a postdoctoral fellowship to Edinburgh University , where I studied mechanisms and markers of endocrine resistance in breast cancer . Working with data rich methods qPCR microarrays I became interested in data analysis and fully switched to bioinformatics . After completion of MSc in Bioinformatics Cranfield University , 2012 I worked in the Department of Medical Genetics in the University of Cambridge , where I provided bioinformatics support for a variety of studies in heritable predisposition to cancer . Throughout my research career I published many well cited articles about cancer and bioinformatics see publications at https : scholar.google.com citations hl en user hGLjJ kAAAAJ . In 2021 I returned to Cranfield University in a capacity of a Lecturer in Bioinformatics . Till recently , my career has been heavily biased toward research . However , I also always enjoyed teaching . I supervised MSc and MPhil projects in Cranfield and Cambridge Universities . I run a course about RNA sequencing data analysis in EMBL EBI Hinxton , UK . For several years I contributed to teaching in Edinburgh University as an invited Lecturer . I completed PgCert in Academic Practices ; and I am a Fellow of The Higher Education Academy UK . See http : larionov.co.uk for more detail .. Technologies :
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Director , Head of Diagnostic Bioinformatics . . I am computational biologist expert in combining experimental data with theoretical methods , analysing large data sets and figuring out relevant patterns in them . Key techniques and skills Computational modelling in bioinformatics e.g. sequence alignment , genomic pipelines , motif search , variant calling and in structural biology e.g. structure refinement , free energy calculations Statistical analysis of large data sets e.g. dimensionality reduction , pattern recognition , tailored approaches to data analysis e.g. time series analysis , rare event sampling Skilled programmer C C , Python , Unix Shell , experienced user of high performance computer resources Excellent teamwork skills collaborating with a wide range of chemists and biologist to tackle challenging research projects see list of peer reviewed publications Proficiency communicating scientific ideas in manuscripts and in oral communications , extensive experience in writing and evaluating scientific research proposals . Technologies :
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Senior Scientist . Improve efficiency , robustness and compliance of approx . 10 API Active Pharmaceutical Ingredient production routes . Perform trouble shooting on process deviations . Perform process surveillance . . I am a result oriented medicinal chemist PhD with 15 years international experience in pharmaceutical industry and with profound knowledge of the drug discovery process . I have extensive managerial experience , both as project manager and line manager . With my open , empathic and accessible management style I am able to create a positive atmosphere in which people feel free to operate , perform to high standards and are able to develop themselves . I am structured and have eye for detail . With my analytical way of thinking combined with my creativity I am able to generate new ideas based on complex data sets and convert these into working plans or streamlined procedures . I am a team player with a drive to improve processes . Specialties : medicinal chemistry , synthetic organic chemistry , drug discovery , drug design , PET tracer design , nuclear receptors , GPCRs , kinases , endocrinology , fertility , contraception , oncology , immunology , sexual dysfunction , pain , project management , people management , coaching , process improvement , in depth knowledge of Excel , logistics . Technologies :
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PhD in Neuroscience . I am a PhD researcher in the L land group , at the Department of Neuroscience , University of Copenhagen . I am investigating the structure and function of human Neurotransmitter Sodium Symporters NSSs in complex with CNS targeting drugs via cryo EM cryo electron microscopy and pharmacological radioligand binding competition assays . . pharmacist and PhD student : structural biophysics of neurotransporters in complex with CNS drugs , L land group , University of Copenhagen . Technologies : CryoEM
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membrane proteins;interaction;structure
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Advances Workflow Specialist . State of the art Electron microscopy and convencional histology techniques . I started my career in science at Instituto Gulbenkian da Ciencia under the supervision of Prof. Leonor Saude . Due to my ongoing interest in Biology , Anatomy , and Pathology , in 2007 I received my undergraduate degree as a Biomedical Scientist and in a few years , already working as a Histotechnologist at Instituto de Medicina Molecular , I enrolled on master program studying the Histomorphometric and genetic profile in patients with osteoporosis . It was as an Electron Microscopy specialist supervisor in Histology and Comparative Pathology Facility that I have developed strong autonomy and some leadership skills . My responsibilities were coordination of the Department of Electron Microscopy and direct supervision over technical staff . I enrolled in projects that required cryo ultramicrotomy of chemically fixed samples Tokuyasu technique , immuno Gold labelling and CLEM , also rtTEM and negative staining of biological and non biological samples . In a more clinical context , I was involved in the re establishment of the Primary Ciliary Dyskinesia service in Portugal . I recently started to work as a Thoracic Research Associate at the Royal Brompton Hospital , working with the Primary Ciliary Dyskinesia PCD team under the Supervision of Professor Claire Hogg . My role is to help develop as artificial intelligence deep machine learning tool to help in the diagnosis of PCD , to make it quicker , friendlier and hopefully even more reliable . I am also involved in many diverse projects in Portugal and in the UK , that involve high resolution Tomography , cryo EM and negative staining of biological material . I am also involved in COVID 19 related projects . Technologies : CryoEM
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Senior Principal Scientist . Medicinal Chemistry for the indication NASH . . Current topics of interest : NASH animalhealth oncology immuno oncology , DNA repair , oncogene signalling endocrinology . Activities focus on design of drug like SMOLs , PROTACs , covalent inhibitors , chemical probes design of DNA encoded libraries . Lars is one of the main inventors of BAY 1895344 Elimusertib , Bayer s ATR Inhibitor , which is currently investigated in phase I clinical trials see NCT03188965 . Join my science network on LinkedIn and follow me on Twitter : WortmannLars . Technologies :
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molecular glues;developing
|
Research Scientist . Group of Surface and Colloid Chemistry , Department of Application Systems Analysis , Division of Protein Chemistry Assays . . I am a Physicist with a PhD degree and 12 years of research and hands on experience within the fields of Experimental Biophysics and Surface and Colloid Chemistry . During these years , I have moved among different disciplines , countries , in academia and industry , and worked with dynamic and international teams . I have also gained experience in project management and Agile ways of working , and thrive with teamwork and communication among colleagues of different backgrounds and disciplines . Currently , I am a Research Scientist at Novozymes , working in the development and implementation of different biophysical , surface and colloid techniques to the mechanistic understanding of enzymes , their interactions with substrates and formulation components , and their application mainly in biological detergents and in food . Before this , I worked as postdoc and assistant professor at the Dep . Pharmacy , University of Copenhagen , when I focused on understanding the structural effects and interactions of antimicrobial peptides , nanoparticles and oxidation on lipid membranes , for which I employed neutron reflectometry , SAXS , QCM D , FTIR ATR , DLS and fluorescence . Previously , I was a postdoc at the University of Southern Denmark Odense , working on the application of micropipette manipulation to characterize different interfacial and colloidal systems , such as liposomes , surfactant and lipid coated interfaces , microparticles and emulsions , as vehicles for peptides and hydrophobic drugs . I have a BSc in Theoretical Physics , a MSc in Biomedical Physics , and a PhD with distinction cum laude from Complutense University Madrid , Spain , with stays at the University of British Columbia Canada and Universitat Jaume I Spain . My research during my PhD studies was around the lipid protein interactions , structural and mechanical effects of the two hydrophobic lung surfactant proteins on lipid membranes , crucial for the design and development of clinical surfactants for lung therapy .. Technologies : SLS DLS
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enzymes;characterization;formulation;interaction
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Research Associate II , Autoimmunity Transplantation Inflammation . Generating biochemical profiling data for compound screening Developing and optimizing in vitro enzymatic assays using LC MS as readout Exploring alternative methods antibody based detection , ELISA and FRET based assays , biotin pull down assay , protein degraders Expression of recombinant proteins in mammalian cells Cloning , mutagenesis and design of plasmids Cell culture and cell transfection In vitro translation of proteins Western blot and WES JESS technology , qPCR , HTRF , immunofluorescence , FACS . . Technologies : FRET
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molecular glues;small molecules;characterization;expression
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Principal Scientist , Computational Biology . . Experienced data scientist developing computational strategies to interpret Big Data from genomics , illuminating how neurons and immune cells work .. Technologies :
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Scientist . . Experienced Scientist working in the Biotech Industry . Strong research professional skilled in Protein Chemistry such as Protein Engineering and Design , Protein Interactions , Phage Display , Protein Purification , Protein stability Structure .. Technologies :
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proteins;engineering;interaction;stability
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Senior Bioinformatician . . Software developer Bioinformatician with over 15 years experience working in both the Bioinformatics and Genetics domains . I combine extensive experience in software development with an understanding of science of Genetics . Specialties : IT : Java , Perl , Unix scripting , Oracle PL SQL , database design Other : Genetics , sequence similarity search tools , statistics . Technologies :
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Bioinformatics Scientist II . . I 'm a bioinformatics scientist and software developer that is committed to providing NGS technology for clinical decision making . I have worked on integrating secondary and tertiary sequence analysis software to identify relevant treatments for somatic mutations , and developed bioinformatics components to a somatic pipeline . As a doctoral student , I have collaborated with immunologists and clinicians to develop novel bioinformatics methods to identify key epigenetic markers to quantify immune cell composition from patient blood . In addition to developing sequencing tools for clinical reporting and biomarker discovery , my interest lies in leveraging molecular data for clinical analysis and interpretation . . Technologies :
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Bioinformatician . . Analytical and proficient bioinformatician with over 8 years of experience in a research environment using a variety of programming languages and techniques . Highly trained to analyze a variety of biological and experimental data sets , with a specific emphasis on large data sets . Experienced in working collaboratively across projects and different institutes .. Technologies :
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Associate Professor . Research the structure and function of P2X receptors using cryo electron microscopy and X ray crystallography with Dr. Steven Mansoor . Solve structures of membrane proteins using cryo EM and crystallography . Design and test molecules with potential to bind proteins . Build , maintain , supervise , and run the laboratory cell culture facility and cell lines , including insect and mammalian lines . Grow and maintain chemical laboratory and equipment inventories . Serve as laboratory safety officer . Complete protein expression , purification , and characterization in bacterial and cell culture systems , including the use of FPLC , HPLC , SDS PAGE , and other techniques . Plan and construct of new expression vectors . Build and maintain Linux computer systems . Assist with writing and submission of publications and grants . Train , supervise , and mentor new lab members . Serve on the graduate admissions committee . Teach occasional classes . Research Associate , August 2020 October 2021 . I have a passion for working with proteins and drug molecules that matter to human health . My areas of expertise include protein biochemistry , tissue culture , structural biology , crystallography , and single particle cryoEM . Unlike most PhDs that are experts in only one system , I have an expansive understanding of general biochemistry having taught university level biochemistry with laboratory for fifteen years . There is no better way to learn something than to teach it . I love working with my students to create valuable and meaningful learning through experiences in the classroom and the laboratory . In addition to covering core biochemistry topics , I have also taught the biochemistry of cancer , wound healing , HIV , Ebola , chemical warfare not my idea , CRISPR , and now Covid19 , among many other things . I always maintained my involvement in and love for reseach both in my own lab and others . I have worked as a visiting scientist in labs at Yale , Northwestern , and Oregon Health and Science University twice over multiple summers and during my sabbatical , gaining a wealth of experience and learning new techniques in protein chemistry and structural biology . Outside of science , I served as the artistic director for Portland Actors Ensemble Shakespeare in the parks in Portland for six years and led the group to significant audience and financial growth . Publications can be found at NCBI PUBMED : Godsey MH Author . Technologies : Xray;CryoEM
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membrane proteins;proteins;small molecules;characterization;interaction;structure
|
Consultant Process Scientist . . Consultant Process Scientist at Regeneron , Limerick . . Working for the Manufacturing Support team in the Process Sciences department . . Experience in both upstream and downstream across multiple monoclonal antibody products . Previous experience working in Operations at MSD , Brinny , in the manufacturing of conjugate vaccines . . Technologies :
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Physicist . . I investigate ultrafast dynamics in atoms and molecules . In strong field physics , I calculate the dynamics of molecules acted upon by laser fields . In biological contexts , I calculate the evolution and decay of quantum information due to interactions with the surrounding environment . The role of quantum mechanics in biological systems touches on fundamental questions regarding quantum information processing in systems experiencing decoherence . In addition to developing new theoretical treatments for photosynthetic molecules and the avian magnetic compass the way migrating birds tell which way is North , I have developed a quantum algorithm which makes use of incoherent , irreversible processes to solve NP complete problems . Specialties : theoretical physics , ultrafast dynamics , time dependent Schroedinger equation , decoherence , quantum physics , strong field physics , quantum information , quantum algorithms , quantum biology . Technologies :
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Scientist . . I am Scientist at Denali in Structural Biology . I have the ability to drive projects to completion , as shown by numerous first author publications , including in Nature , Nature Structural and Molecular Biology and Nature Communications . I have technical expertise in X ray crystallography , cryo EM , biophysics , and the purification and characterization of difficult protein systems . I have commercial experience through my previous work as a corporate lawyer , and I am admitted to practice in Victoria , Australia .. Technologies : Xray;CryoEM
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proteins;characterization;structure
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. . Highly organized , motivated researcher , proficient in biochemistry and X ray crystallography of proteins and protein complexes ; currently working with CryoEM of membrane proteins in nanodisks and liposomes .. Technologies : Xray
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membrane proteins;proteins;interaction;structure
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Pfizer Summer Growth Experience Informatics for Molecular Pharmaceutics Intern . . Pursuing a Bachelor 's degree in Bioinformatics and Computational Biology and Computer Science at Worcester Polytechnic Institute , expecting to gradate in May 2023 . Seeking an internship position for the upcoming summer 2022 or full time employment opportunities post graduation , with a general interdisciplinary interest in software use and development , lab work and or other practical and professional experience . Other Involvements Include : Residential Advising VOX Musical Theatre Alpha Xi Delta Iota Xi Chapter Technichords A capella Alden Voices Choir . Technologies :
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. . Structure Biology , single particle Cryo EM , DNA repair . Technologies : CryoEM
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proteins;structure
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Director of Preclinical Pharmacy . . I have more than 16 years of experience in Translational research in the field of Radiopharmaceuticals for Molecular Imaging and Cancer Therapy in Academia and in Pharmaceutical industry . Authored 64 peer reviewed scientific publications of original research as a PhD student , Post Doc Research Associate and as Senior Research Fellow . As a member of international renowned research groups , I led a number of international collaborations of diverse projects in the field of Radiopharmaceuticals . My research focus is the preclinical characterization of molecularly targeted systems as diagnostics and or therapeutics for translational applications . These systems include small molecules , peptides and proteins . My research efforts have included the development of Radiopharmaceuticals for Peptide Receptor Radiotherapy PRRT , Alpha Targeted Therapy TAT and Theragnostics for cancer therapy and diagnosis , as well as the development of molecular imaging prognostic biomarkers for brain and immune function , infectious diseases , using advanced state of the art small animal imaging platforms . I have gained strong skills in Research project management , knowledge and experience in Radiochemistry , RadioBiology , Radiopharmacology , Analytical Chemistry , GLP GMP QC , Protein Chemistry , In Vitro , Animal studies , Dosimetry and Imaging .. Technologies :
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peptides;proteins;small molecules;characterization;developing
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Consulting Statistician . Part of a team designing , implementing and testing novel Bayesian hierarchical models to estimate and forecast population estimates . Implemented time series models regARIMA and State Space Models SSMs to produce international migration estimates . Created a tutorial on SSMs and a user guide to enable other teams to understand and run the models and build on the R code . Work with academic advisors to implement , test and document Age Period Cohort based models to project UK mortality rates in R. Created a user guide to explain the models and their implementation in detail . Improved the R code and added comments to explain what each line does and how it does it . Analysed large demographic datasets using Python and PySpark in Cloudera and Hue . Provide ad hoc statistical and programming support . Attend consultations with academic advisors and assist in the interpretation of ideas to team members . Developed new methodology for uncertainty measures for population estimates based on administrative data . Other statistical methods and concepts applied in this role include generalised linear models , generalised additive models , survival analysis , k means and hierarchical cluster analysis , simulation , and probability density functions . . I have more than 20 years of experience in mathematics and statistics with a wide range of applications , including finance , Actuarial Science , cell biology , gene expression , pharmaceuticals , biometry , complexity science , and demography . I graduated from the University of Southampton with a 1st class degree in Mathematics , and went on to gain an MSc in Biometry statistics applied to biological data , with distinction , from the University of Reading . I applied my knowledge as a statistician at the University of Reading , working on consultancy projects , and teaching at a range of levels . I completed my PhD in Applied Mathematics at the University of Southampton . In the first year of the integrated PhD I followed an MSc in Complex Systems Simulation , for which I obtained a distinction . I then developed considerable expertise in stochastic models in biology , resulting in significant research output from my PhD in world leading journals , including Physical Review Letters , Nature Cell Biology , and Biophysical Journal . I spent a year at the Duke NUS Medical School , in Singapore as a Research Fellow , analysing high dimensional gene expression data in cancer cells . I then returned to the UK to work as a consulting statistician contractor at the Office for National Statistics in the UK . I am open to statistical and data science roles in Europe and the USA . I enjoy programming in Python , R and Matlab , and am comfortable working in development environments , including Git , GitLab , Linux , and remote virtual machines .. Technologies :
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Principal Scientist . . Creative , adaptive , self motivated , quick learning , and innovative scientist who has been a dynamic team member within multiple small molecule drug discovery research organizations delivering clinical candidates .. Technologies :
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small molecules
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PhD Student and Graduate Teaching Assistant . Pursuing a PhD in Chemistry in the lab of Dr. Steve Reichow at Portland State University . Serving as a Lead Graduate Teaching Assistant for upper division biochemistry laboratory courses . . I am a PhD student at Portland State University studying vision and ageing with cryo electron microscopy . I have prior research experience in the application of X ray Crystallography to study blood coagulation proteins at Western Washington University .. Technologies : Xray;CryoEM
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proteins;structure
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Postdoctoral Researcher . Visual Proteomics , Department of Molecular Sociology Beck group . I am an experienced and versatile cryo electron microscopist , with broad experience in many cryoEM techniques , particularly in single particle analysis and cryoCLEM . I am passionate about using my expertise in and further developing various electron microscopy techniques to help scientists answering their research questions . I combine a technical background with good personal and excellent communication skills . I am easy to get along with , eager to learn , organisedand enjoy interacting with scientists in an international environment .. Technologies : CryoEM
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structure
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Postdoctoral Fellow . . I am a quick learner and passionate about tackling new problems . I have studied the molecular machinery for both photosynthesis and respiration during my PhD using an array of biochemical and biophysical techniques , such as enzymatic activity assay , ligand binding titration , electron paramagnetic resonance , time resolved optical spectroscopy . From these training , I truly believe the key to cure any disease or engineer any microbe is to understand the function of molecular complexes at the microscopical level . Currently , I am applying computational methods to study membrane protein complexes with the help of experimental data from cryo EM .. Technologies : CryoEM
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membrane proteins;interaction;structure
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Principal Bioinformatics Scientist . . Experienced scientist with a demonstrated history of working in the biotechnology industry . Skilled in Mathematical Modeling , Matlab , Python , Bioinformatics , and Computer Science . Strong information technology professional with a Doctor of Philosophy PhD focused in Computer Science from University of Tasmania . . Technologies :
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Senior Science Fellow . . 20 years of experience as a medicinal chemist and project leader Bayer AG Proven success at advancing multiple programs through all phases of drug discovery : hit validation , hit to lead , lead optimization and candidate selection Track record in many indications , cardiology , hematology , thrombosis research , bacteriology , virology , oncology , diabetes research , parasitology AH Expertise with many modalities aside from std . SMOLs : peptides , peptidic and SMOL prodrugs , peptide drug conjugates , antibody drug conjugates , molecular glues Acquaintance with HTS , structure , fragment and DEL based projects Interest in Mixed Modalities , Molecular Glue , Antibody Drug Conjugates ADCs , non viral Vectors , Lipid Nano Particles LNPs Management experience with in house chemistry teams , contract research organizations CROs and academic partners and nonprofit organizations : DnDI , IVCC , BMGF , IMI Sophistication in lab automation , software design and IoT based lab of the future . Technologies :
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molecular glues;small molecules;peptides;developing;screening
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Scientist . . An experienced , high performing Synthetic Organic Medicinal Chemist adept in the art of organic synthesis and medicinal chemistry with over 14 years of experience in small molecule drug discovery . Proven ability to work within a multi disciplinary team to drive research programs toward successful conclusions . Skilled in the design and execution of multi step syntheses of targeted molecules ranging from milligram to multi gram quantities Proficient with modern spectroscopic 1 D and 2 D NMR , LC MS , HPLC , GC MS and chromatographic flash chromatography , TLC , chiral and reverse phase HPLC methods Prepared presentations and routinely presented and discussed research with medicinal chemistry department during monthly group meetings Experienced in kinase , transporter , tryptophan hydroxylase and phosphodiesterase and additional enzyme targets for immunologic , ophthalmic , and metabolic indications Working knowledge of ADME and pharmacokinetics Interpretation of SAR as applied to lead optimization of advanced targets Knowledge of chemistry related software CambridgeSoft Chemdraw , CAS SciFinder , Reaxys , MDL ISIS Draw and ISIS Base , ACD find , ACD Spectrus Processor and Discovery Studio . Technologies : NMR
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small molecules;developing
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Director of Scientific Computing . Algorithms for cancer diagnosis ; genomics and variation analysis ; biological databases and high performance computing . . Experienced software systems architect and computational biologist specializing in high throughput data analysis systems for molecular diagnostics , genomics metagenomics , materials science , security , media , and finance . Human and non human genomic analysis , with a specialty in functional gene annotation and clinically relevant mutation classification . Extensive experience with AWS . Embedded systems experience in C and C . Technical leadership and experience working on cross functional core teams . DBMS and enterprise security expertise including HIPAA , with emphasis on networked , parallel , and distributed systems . Database internals and non relational data stores . Whole system hardware and software design and implementation , with particular care given to simple , reliable architecture and thorough documentation . iOS application development , along with corresponding backend processing . Machine learning approaches for the analysis of large amounts of structured and semi structured data . Systems for the design of novel biomaterials . Specialties : structural and synthetic biology , multithreaded multicore design , systems design , biomedical informatics , HPC , materials science , media video audio processing , and startup culture .. Technologies :
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Associate Scientist . . I graduated from San Jose State University in 2018 with B.S. in Biological Sciences concentration in Systems Physiology and a minor in Chemistry . Currently , I am pursuing a M.S. in Bioinformatics at San Jose State University . I am a highly motivated and driven individual with years of experience in healthcare and biotech pharmaceutical industry alongside an academic background comprising life and computer sciences . I am well versed in quality control , wet lab analysis , and team leadership . I am currently looking for opportunities to further my career in the biotech and pharmaceutical industries .. Technologies :
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Biochemist . . Master of Science in Engineering , Biotechnology Cand . Polyt . ; Biotechnology , Elite programme in protein biophysics , and PhD Medicine . Seven years of experience of planning , designing and conducting research as well as analysis , evaluation and documentation of results . Strong networking and communication skills both in Danish and English due to many years of collaboration with international partners and presentation of projects on international meetings and conferences . Broad knowledge in biomedicine , neuroscience , biochemistry , protein chemistry , molecular biology , analytical chemistry . Experienced in supervising and instructing technicians and students in the laboratory , planning and presenting chemistry lectures for medical students and chemistry high school . Technologies :
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proteins;characterization
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Computational Biology PhD candidate . PhD Candidate in Drs . James M. Briggs s and Mehmet Sen s Labs at University of Houston Utilize supercomputer clusters at the research computing data core RCDC operated by The Hewlett Packard Enterprise Data Science Institute HPE DSI at the University of Houston for performing research simulations . Routine use of command line interface tools and programming languages Terminal , Vim , Python , R , C for data analysis . Projects : Perform ed metadynamics simulation for proteins including leukointegrin CD11c CD18 and Universal stress protein UspA616 incorporating nuclear magnetic resonance NMR , small angle X ray scattering SAXS and cryogenic electron microscopy Cryo EM data . Performed molecular dynamic simulations and small molecule complexed simulations for liver X receptor LXR protein . Experienced Researcher with a demonstrated history of working in the biotechnology industry with a strong background in Assay development . Skilled in Cell Culture , qPCR , Cell Based Assays , ELISA , SDS PAGE and other Biotechnology techniques . Strong research professional with a Master 's Degree focused in Clinical Laboratory Science Medical Technology Technologist from University of Massachusetts Lowell . Currently pursuing a PhD in Biochemistry at University of Houston .. Technologies : Xray;CryoEM;NMR
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Team Leader , Senior Scientist . . I have 8 years of solid scientific experience in protein biochemistry and protein purification for crystallisation . During my work experience from academia and industry I gained some high expertise in membrane GPCR , Transporter and soluble proteins enzymes , antibodies , ... . I have set up and optimise some process for protein expression , reconstitution proteoliposome , nanodiscs , purification Chromatography and functional characterisation binding assay , ELISA , fluorescence spectroscopy , SAXS , FT IR , DLS , ... . Expert in : Protein Purification ; FPLC ; Heterologous expression of Membrane and Soluble protein in Yeast , bacteria , mammalian cell ; Radioligand Binding Assays ; Fluorescence Quenching , Labelling , ELISA ; Molecular biology ; Plasmid construction ; Mutagenesis ; Nanodiscs ; Proteoliposomes . Technologies : SLS DLS
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antibodies;membrane proteins;proteins;characterization;expression;interaction;structure
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Postdoctoral Researcher . Using cryo electron tomography to study cellular structures in unprecedented detail . . Collaborative scientist and communicator with 10 years of experience in cell and developmental biology . Currently using cryo electron tomography to study cellular structures within diverse organisms . Skills include research , teaching , mentoring , and producing engaging scientific content for wide ranging audiences .. Technologies : CryoEM
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structure
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Scientist . . I am a highly motivated and results oriented scientist . In Industry , I have worked with many projects to characterize interactions between protein drug candidates and their target molecules as well as genetic engineering and mammalian cell line development for antibody production . During my time in academia , I worked with protein engineering where I developed several new methods and concepts for engineering and characterization of proteases and affinity proteins . . Technologies :
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proteins;small molecules;expression;interaction
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Scientist I . . . Technologies :
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Marie Curie Early Stage Research Fellow . One of the 14 ESR research fellows in the H2020 MSCA ITN project AiPBAND An Integrated Platform for Developing Brain Cancer Diagnostic Techniques . Dr. Xiaoyu Zhang is a Marie Curie ESR Fellow at Imperial College London . His current research interests include machine learning , medical AI , and bioinformatics .. Technologies :
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Staff Research Scientist . Thomas C. Marlovits Laboratory cryo EM specialist . . Technologies : CryoEM
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structure
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GPCR Drug Discovery Scientist . . . Technologies :
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Assistant Professor , UCD School Of Medicine . . I am a medical graduate and obtained my Ph . D. in Immunology from Umea University , Sweden in 2007 . I am the Translational Research and Engagement Manager for Precision Oncology Ireland POI , based in UCD , Dublin Ireland . I run the Tissue Imaging Platform for POI . Our main focus is on cancer biomarker development using digital pathology . We use IHC , ISH , Multiplexing , and both quantitative and advanced AI based image analysis algorithms for tissue based biomarker development . We put particular attention on commercial antibody validation . . Irish Cancer society award winner Senior Researcher of the Year 2020 . UCD Value in Action VIA award winner 2020 . . Technologies :
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Principal Bioinformatics Scientist II . . Designed and developed computational tools for novel discoveries of driver genes used internally for drug target discovery and experimental design . Performed downstream genomic data analysis and integrated system biology level data resources gene essentiality , synthetic lethality , pathways to prioritize potential cancer drug targets . Processed and analyzed pharma related Big Data for Drug Repurposing . identified approved drugs with potential new disease areas Applied machine learning techniques e.g. , regression , k means , random forest , and PCA to predict drug side effects . Developed data pipelines to incorporate acquire , clean , link , process , and organize data from diverse databases . Acquired ten years of experience with software development for data manipulation and analysis . developed NMSim and RCNMA ; published in scientific journals and being used at Merck KGaA. Designed and developed web servers and data resources using data mining , algorithm development , statistical analysis , data modeling and predictions . www.bindingmoad.org provides the specialized biochemical data and visualization . www.nmsim.de provides protein modeling and simulations for user submitted jobs . Conducted and analyzed benchmark exercises in the Community Structure Activity Resource www.csardock.org improved 200 user participation by data mining relevant users and advertising . Attained solid background in programming C C Python Perl Fortran R Java Linux , data analysis tools R , JMP , MS Power Pivot and databases MySQL , Oracle . Published 11 peer reviewed articles in reputed scientific journals , written grant proposals , and presented results in many conferences .. Technologies :
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Senior Director Protein Sciences . . Structural Biologist Biophysicist with 12 years of experience in membrane proteins . Focus on structural dynamics and mechanisms of action of ion channels and transporters . Experienced in designing and expressing constructs , biochemical and spectroscopic analysis and structure determination . Productive in project leadership and in collaborative effort , highly organized and goal oriented .. Technologies : Xray;CryoEM
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membrane proteins;characterization;structure
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Group Leader , Senior Principal Scientist . Medicinal Chemistry , Head Specialized Chemistry Technologies . Roche Pharma Research and Early Development pRED , Medicinal Chemistry , Roche Innovation Center Basel . Rainer E. Martin , PhD , is a Senior Principal Scientist and Group Leader heading the chemistry technology group in Medicinal Chemistry at Roche Pharma Research and Early Development pRED , Roche Innovation Center Basel Switzerland . In his current position , he is committed to modern leadership according to the VACC principles . Scientifically , he focuses on modern synthesis technologies with a focus on parallel , flow and electrochemistry . . Rainer received his PhD in organic chemistry from ETH Zurich in 1998 and spent two years as a postdoc at the University of Cambridge UK , supported by a grant from the Swiss National Science Foundation SNF and a Junior Research Fellowship from Churchill College . He joined Roche in 2000 , initially working in formulation research , before moving to Discovery Chemistry in 2002 . Since then he has been working on various projects that covered a wide range of disease areas . . Specialties : Drug discovery , polymer chemistry , lead generation and lead optimization , chemistry technologies flow chemistry , photochemistry , electrochemistry , late stage functionalization , parallel synthesis and screening , antibody drug conjugates ADCs , outsourcing collaborations . . Academic Visitor at the Innovative Technology Centre ITC in the group of Prof. Steven V. Ley , Department of Chemistry , University of Cambridge , UK . Research in the field of flow chemistry . . Technologies : ITC
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antibodies;small molecules;screening
|
Senior Director , Bioinformatics and Data Science . . Creative and highly motivated manager and data scientist specializing in RNA biology and small molecule drug discovery , from target identification through biomarker validation . Strong group leader , communicator , and collaborator .. Technologies :
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ML Science Manager . . We are hiring ML scientists at all levels with background or interest in adversarial ML , online and offline RL , sequence modeling , large graph analytics , and cybersecurity analytics . If you are interested please share your resume or apply here : https : lnkd.in e38DVSS2 amazon hiring ml rl graph artificialintelligence cybersecurity . Technologies :
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Senior Scientist . . Pursuing a role as a scientist in synthetic biology , computational biology , or related fields . . Technologies :
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Principal Scientist . Leading assay development , validation and regulated bioanalysis platforms : Ligand binding assays , including ADA assay MSD . Cell based immunogenicity assays , including NAb assay and ELISpot assay . qPCR assays , including viral shedding assay . Developing bioanalytical strategies for gene therapy programs . 2 . Managing CROs Leading evaluation reassessment of CRO s capabilities in supporting regulated bioanalysis and lab audits . Managing assay development , qualification , validation , and bioanalysis for clinical studies conducted at CROs in the US , Canada , UK , and France . 3 . Representing bioanalysis in cross functional teams Contributing to internal cross functional meetings with Research , Pharmacology , Toxicology , CMC , clinical operation and clinical development . Contributing to external team meetings with central lab and clinical trial managing organization , including sample collection processing instructions in the lab manual , and DTA drafting , reviewing , and implementation . Facilitating sample tracking among clinical sites , central lab , and bioanalytical CRO labs for global clinical studies . 4 . People management and in house biomarker bioanalytical assay development validation Leading a scientific team to develop in house large molecule biomarker assay and viral shedding gene therapy assays . Equipment evaluation , purchase , set up , training and maintenance . Evaluating new technologies . Contract managing and negotiating . . A highly motivated team lead and scientist with excellent strength in quick learning , strategic analytical thinking , ideation , intellection , problem solving , and people management . Lead assay development , validation and regulated bioanalysis of immunogenicity ADA , NAb , and T cell response , biomarker , and viral shedding assays in gene therapy drug development . Oversight of external CRO partners Strategic planning of resources and ensuring high quality deliverables within timelines in support of key stakeholders Experienced in representing bioanalysis in cross functional teams . Excellent written and oral communication skills . In depth knowledge in Drug development , both gene therapy and small molecule FDA EMA Guidance , including Bioanalytical Method Validation , Immunogenicity , Viral shedding Prism , Abase and Biovia Electronic Notebook ELN . Technologies :
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carriers;proteins;expression
|
Research Scientist Manager . . We are hiring . Technologies :
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Director , Computational Biology . . . Technologies :
| null |
Senior Director , Bioinformatics . Building and leading a cross functional team supporting the development of a revolutionary molecular analysis platform . . Computational Biologist with 20 years of professional software engineering experience and expertise in Next Generation Sequencing , Machine Learning , and Clinical Bioinformatics . Currently Senior Director of Bioinformatics building and leading a team to support the development of revolutionary scientific instrumentation . Formerly Director of Engineering at DNAnexus , Principal Scientist at PGDx now LabCorp , and an American Diabetes Association Postdoctoral Fellow at the NHGRI in Dr. Francis Collins ' laboratory . Current publication list on Google Scholar . Specialties : Experimental design and analysis of genome scale data using cloud technologies . Software engineering in Rust , Scala , Python , and R. Bioinformatics tools and methods .. Technologies :
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Visiting Scientist . . . Technologies :
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Senior Scientist Lab Head , Roche Pharma Research and Early Development pRED . Responsible for characterization of therapeutic antibodies and next generation biologics using mass spectrometry and biochemical analytics . Additional focus on laboratory hardware IT automation workflows and high throughput approaches . Leading a lab with three research associates , two IT scientists and a postdoctoral research scientist . Working in or leading therapeutic research and early development , as well as technology project teams in a matrix environment . . Senior scientist with more than 10 years of experience in protein biochemistry and analytics , focusing on mass spectrometry , high throughput approaches and lab and IT automation . Working on therapeutic antibody portfolio and technology projects both as a lab head as well as in a dynamic matrix environment . . Technologies :
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antibodies;biologics;characterization;screening
|
Director of Clinical Informatics Data Science . Lead a team of clinical data managers and clinical data analysts for clinical studies and clinical trials . . Broad knowledge in biological data analysis NGS , single cell sequencing , microarray , genetics , and genomics and algorithm development . Solid track record in supporting assay and product development . Experienced manager of building and managing bioinformatics teams . Extensive experience in working with multiple functional groups .. Technologies :
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Senior Scientist I , protein engineering . . Highly motivated and skilled protein biochemist and structural biologist with over four years of post graduate experience in academia . Expertise in X ray crystallography and cryo electron microscopy , protein purification from a variety of expression systems E. coli and S. cerevisiae , and protein biochemistry to probe intermolecular interactions . Exceptional leadership abilities as evidenced by both individual and group management roles . Outstanding written and oral communication skills as demonstrated by numerous presentations . Efficiently works autonomously or as part of a cross functional team , as shown by multiple independent and collaborative projects resulting in high profile publications .. Technologies : Xray;CryoEM
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proteins;engineering;interaction;structure
|
Postdoctoral Researcher . Cell to cell communication via plasmodesmata , cryo electron microscopy on proteoliposomes , interactomics . Experienced Doctoral Researcher , graduate from University of Montpellier , with a demonstrated history of working in academic research . Microscopy and all kinds of shiny , bright proteins fan . From macro to super resolution . Fundamental plant cell biologist that fundamentally loves all animals as well .. Technologies : CryoEM
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proteins;structure
|
Principal Scientist . . . Technologies :
| null |
Newcastle University Academic Track NUAcT Fellow . . I am a Newcastle University Academic Track NUAcT Fellow . I am part of the Brain and Movement BAM Research Group at the Translational and Clinical Research Institute of Newcastle University and I have been contributing to build the digital health theme within the group . I also serve as the Innovation , Methodology and Application IMA Early Career Researchers representative within the IMA theme and in 2022 I have been elected Chair of the Early Career Researchers Working Group of the BioMedEng association Council . I am an Associate Editor for the IEEE Journal of Biomedical and Health Informatics IEEE JBHI . My expertise and translational research interests focus on digital health . In particular , I am interested in the use of wearable technology and in developing analytics for quantification of digital mobility outcomes in ageing and neurodegenerative diseases e.g. Parkinson 's disease , to enhance remote monitoring and clinical management . I have been involved in the V TIME project : Virtual reality Treadmill combined Intervention for enhancing Mobility and reducing falls in the Elderly . The project ended in 2015 ; findings of the study have been published in The Lancet https : www.thelancet.com journals lancet article PIIS0140 6736 16 31325 3 fulltext . I am currently involved in the Mobilise D project as a task leader . The project aims at connecting digital mobility assessment to clinical outcomes for regulatory and clinical endorsement . The project is funded by the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 820820 . This Joint Undertaking receives support from the European Union 's Horizon 2020 research and innovation programme and EFPIA . Website : http : www.mobilise d.eu . Technologies :
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Head of Scientific Partnerships , Data Sciences Platform . Build partnerships focusing on accelerating science through software engineering at the Data Sciences Platform . Educate partners about the solutions and capabilities of the Data Sciences Platform through demonstrations and presentations . Define solutions with corporate and government funding partners to serve scientific initiatives . Represent the scientific community when evaluating market needs and program direction . Identify funding leads and evaluate those leads in the context of our current project portfolio . Author letters of interest , proposals and funding applications . Coordinate with stakeholders and internal teams to define a statement of work as projects are funded and yearly thereafter to guide execution . As a Principal Investigator , Investigator , or lead on funded initiatives , maintain oversight during the life of funded projects . Review team work and demoes to assure milestones are met as defined in the statement of work . Risk manage milestones and delivery of work with stakeholders and internal teams . . I am passionate about bringing together data science and software engineering to accelerate science initiatives . Leveraging extensive experience with Next Generation Sequencing NGS assays , I have broad experiences in creating portals , cloud native data centers , scalable analysis pipelines , and data modeling to support a variety of scientific initiatives . Most recently , leading projects focusing on single cell genomics , previous experiences include de novo assembled and reference based population derived RNA Sequencing methodology specifically variant calling and fusion detection , analysis of metagenomic data sets WGS and 16S , statistical techniques for microbial biomarker detection in sparse high dimensional data and the application of array technology to ovarian tumor research .. Technologies :
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Research Fellow . Metagenomics : integrative analysis of multi omics data from a large cohort Gut tissue single cell transcriptomics data analysis Spatial transcriptomics data analysis and method development . An experienced computational biologist with strong passion for understanding biology with computational approaches . Proficient in mining , visualizing , interpreting and modeling high throughput sequencing data . Interested in a broad range of biological problems , especially understanding the dynamics of microbial communities . Recent CV : https : github.com lch14forever CV raw master cv.pdf . Technologies :
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Senior Researcher . . I am a highly enthusiastic and motivated senior research scientist . My strength lies in my multidisciplinary background . I have a strong theoretical knowledge base in Biological Sciences , Biochemistry , Pharmaceutical sciences and experience in Computational modeling and simulations of biomolecules . I work in an interdisciplinary environment , where I am able to combine both experimental knowledge and computational predictions to understand better the fundamental nature of the biological processes at the molecular level . . My research involves computational modeling of 3D structures of proteins , development of prediction protocol for identification of food derived taste peptides , and establishing computational methods to accurately predict the binding mechanism and selectivity of taste receptors G Protein Coupled Receptor to endogenous peptides and food derived taste peptides . Previously , I have been involved in studying the membrane protein simulations , predictions of antibody structure , antibody antigen docking and simulations , in silico and in vitro design of high affinity antibodies , . In my research , I have used different computational software suits such as Rosetta for structure predictions , protein protein docking , Molecular dynamics software such AMBER , NAMD , Gromacs , and Schrodinger software package , data analysis tools . I have gained experience in programming : advanced bash scripting , Python , R script , and Linux operating system . I defended my Ph . D. thesis titled : Molecular modeling and simulations of protein , membrane and ligand interactions on 13 12 2017 with Magna Cum Laude under the supervision of Prof. Rebecca Wade in the Molecular and Cellular Modelling MCM group at the Heidelberg Institute of Theoretical Studies HITS gGmbH and co supervision of Prof. Christian Klein , director IPMB Medizinische Chemie , Universit t Heidelberg . I did my Postdoc in the B Cell Immunology group at German Cancer Research Centre , under the supervision of Prof. Hedda Wardemann and currently working as a senior research scientist in the group of Molecular Modeling group headed by Dr. Antonella Di Pizio . My area of specialties include : . 1 Molecular modeling of 3d structures mainly for antibodies . 2 Protein protein interactions : antibody antigen and GPCR peptide . 3 Molecular docking of small molecules agonist , antagonist , . 3 In silico and in vitro antibody affinity maturation . 5 Multiscale simulations of biological membranes , protein membrane , protein protein interactions . 7 Data analysis in R , Programming with Python , Bash , Linux . Technologies : Xray
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Guest Editor . . My research is mainly to develop methods to unveil the hidden biological circuitries underlying the data , from understanding sequence based regulations to the genomes or proteome and their impacts to diseases , including : i Decoding genomic sequence to decipher connections between sequence , functions , and phenotypes , especially leveraging sequence data and deep learning models ; ii Developing new approaches for prioritizing actionable mutations characterized human diseases ; iii Investigating gene expression patterns in human traits diseases utilizing epi genomics data ; iv Data integration , database construction , webserver platform development ; v Multi omics data analysis and a variety of bioinformatics statistical modeling .. Technologies :
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Associate Professor . The major focus of my research is on membrane protein structure , function and dynamics . Using a combination of biophysical techniques , including X ray crystallography , absorbance spectroscopy , X ray scattering and X ray free electron laser biomolecular imaging , we study proteins and enzymes at work . I am particularly interested in two groups of membrane proteins ; energy converting enzymes such as cytochrome oxidase and reaction center , and drug discovery related proteins such as the antibiotic target MraY involved in bacterial cell wall synthesis and the cytochrome P450 protein family . I am involved in developing novel structural X ray methods and have an interest in how these can be applied to structure based drug design . . I am a structural biologist biochemist with experience from pharmaceutical industry . I am leading a research group at the Department of Chemistry and Molecular Biology at the University of Gothenburg . The focus of my research group is protein structural dynamics and structure based drug design with a special focus on membrane bound proteins . We use a combination of different biochemical and biophysical methods such as X ray crystallography , absorbance spectroscopy , X ray Scattering and serial crystallography using X ray Free Electron Laser XFEL and synchrotron radiation . We are particularly interested in energy converting systems of the cell including the respiratory enzyme cytochrome oxidase , and antibacterial protein targets . Link to publications : www.researchgate.net profile Gisela Braenden publications . Technologies : Xray
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membrane proteins;interaction;structure
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Epidemiologist . Public health research with Travis C. Porco and Thomas M. Lietman . . I use mathematical models , statistical analysis , and software simulations to investigate collective behavior of populations and communities . Ongoing research includes disease transmission dynamics , emergence of cooperation in repeated interaction between individuals using old school game theory in unorthodox ways , how a diverse ecosystem can coordinate sustainable use of resources using fairly common mathematical models of evolutionary ecological dynamics in an unusual way and how a network of people can sort through a set of competing options collectively by exchanging information locally using models of stochastic dynamics on networks . Specialties : deterministic and stochastic dynamical systems theory , theoretical population biology , individual and agent based modeling , science and technology studies For publications see https : scholar.google.com citations hl en user ZLkVeQsAAAAJ . Technologies :
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Executive Director , Head of Research and PreClinical Development IT . . . Technologies :
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Manager in Chemical Biology . . Passionate , full of energy and with a thirst of understanding how things work , Jonathan Fauerbach is a citizen of the world , where friends equal family , and family means the world to him . His curiosity inevitably leads him to study Chemistry , where he obtained a Ph.D. in Organic Chemistry and Protein Biophysics from the University of Buenos Aires in Argentina and the Max Planck Institute for Biophysical Chemistry in Getting , Germany . His studies in Germany allowed him to develop novel fluorescent organic reporters with unprecedented sensitivity to protein folding which he applied to the study of alpha synuclein protein misfolding and in vitro aggregation in relation to Parkison s disease . He had the chance to present his work in more than XX conferences and establish collaborations around Europe . In particular , his collaboration with Prof Dr. Wah Chiu led to depicting alpha synuclein intermediates critical in fibrillar genesis and propagation through 3D Cryo EM . Jonathan also developed an interest for nanomaterials and nanoparticles . Soon after his thesis defense on July 2013 , Jonathan joined the Frydman Lab at Stanford University as a Postdoctoral Fellow . Mentored by Prof Judith Frydman , he has focused on biochemical and cellular biology aspects of the Huntingtin protein misfolding , oligomers and protein protein interactions with chaperones and protein quality control systems in cellular models of Huntington s disease . He has also worked on developing biocompatible Photoluminescent Silicon Nanoparticles for targeted live cell imaging and small drugs and peptides delivery . In his free time , Jonathan has led a Multicultural Movie cycle at Stanford , as well as joined and became the President of the Argentine Student Organization with Annual cultural exchange events . He also forms part of an Argentinean Rock Band , called 1818 , and intensely enjoys life in the presence of his wife and son . Creativity and happiness surround his life .. Technologies : CryoEM
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idps;proteins;interaction
|
Cryo EM microscopist and Biochemist . . Currently looking to review papers in the fields of cryo EM , TEM , Structural Biology virology and allied life science fields . Publons profile https : publons.com dashboard records review My expertise mainly involves working with viruses using multiple flavors of Cryo Electron Microscopy . Additionally i have also use biochemistry , protein engineering , antigen antibody interactions , and bispecifics in my research . I am proficient using structural biology allied softwares for data analyses . I have recently joined he Pacific Northwest National Lab as a Cryo EM Biochemist .. Technologies : CryoEM
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antibodies;proteins;engineering;interaction;structure
|
RNA Fellow . . PhD Candidate with basic research experience in molecular biology , RNA sequencing , and small molecule drug discovery , and computational experience studying alternative splicing and differential gene expression in the context of SARS CoV 2 and Myotonic Dystrophy .. Technologies :
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small molecules
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Chercheur postdoctoral . Cryo electron microscopy study of membrane protein in the Axel Innis 's lab . . Technologies : CryoEM
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membrane proteins;structure
|
Senior Postdoctoral Fellow . Head of team BioPOLIM . My research focus is on application and further development of fluorescence polarization microscopy techniques and complementary marker free nano infrared spectroscopic NanIR imaging for investigation in Life Sciences . The research focus of my team BioPOLIM is on application and further development of fluorescence polarization microscopy techniques and complementary marker free nano infrared spectroscopic imaging for investigation in Life Sciences For current projects and my research experience see our team homepage : http : biopolim.de . Technologies : FP
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Research Scientist . Project management and scientific project lead , NMR based screenings and labelled protein QC . Structural biologist specialized in high resolution NMR . Expert in structural based drug design , characterization of protein DNA and RNA molecular complexes Biophysics facility manager , focused on NMR , ITC , MALS and DLS Teacher of computational chemistry and NMR spectroscopy Advanced skills in recombinant protein production Additional experience in virtual screening , docking and molecular dynamics Linux admin with focus on data consolidation and supercomputing Scientific supervisor and coordinator Data analyst with knowledge of Python , R and hands on SQL database systems Team player and team motivator Independent and goal oriented .. Technologies : ITC;SLS DLS;NMR
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nucleic acids;proteins;characterization;interaction;screening;structure
|
Genome Scientist . . Experienced computer biologist with extensive experience of annotation and analysis of eukaryotic genomes .. Technologies :
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Senior Vice President for Research . Responsibilities now include oversight for JAX 's Genomic Education programs in partnership with VP for Education . . Strategic , innovative and entrepreneurial leader with more than 30 years experience managing collaborative research team science , designing and implementing scientific research strategies and applying technology and information science to advance biomedical research and biopharmaceutical businesses . Advised leading university on coordinated , multi school initiative on individualized healthcare research and delivery . Led unique , collaborative translational research programs in oncology and neurology . Developed state of the art bioinformatics and cheminformatics platforms for top 10 pharmaceutical company . Promoted the development and application of emerging technologies , such as text mining and visualization of large , multidimensional data sets big data .. Technologies :
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Expert Research Associate Lead Generation . . Research associate with 6 years of experience working independently , as well as participating in collaborative group projects . Skilled in cell biology , molecular biology , and biochemistry methods with training in single particle cryo EM .. Technologies : CryoEM
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proteins;structure
|
Research Associate . Currently working as Research Associate at Cryo EM CORE facility at UT health McGovern Medical School . Responsibilities include high resolution Cryo EM data acquisition , Sample grid preparation and screening , Carbon evaporation , Scheduling users , Orders and general maintenance of core facility . . Experienced Senior Research Assistant with a demonstrated history of working in the hospital health care industry . Strong research professional skilled in protein biochemistry , molecular biology and microscopy . . Technologies : CryoEM
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proteins;structure
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Senior Principal Scientist . Small Molecule Drug Discovery Novel Drug Modalities : Protein Homeostasis Targeted Protein Degradation . I 'm a highly experienced synthetic organic chemist with expertise in natural product total synthesis , small molecule drug discovery , and protein homeostasis . I have a strong track record of innovation and impact as well as excellent written and verbal communication skills as demonstrated by a consistent patent , publication , and presentation record . Beyond science , my professional passions include teaching and mentorship as well as advocating for greater recruitment , inclusion , and retention of women and under represented minorities in the chemical sciences .. Technologies :
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molecular glues;proteins;small molecules;screening
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Senior Scientist . Liposome Liposomal Drug Delivery System Nanoparticle Asymmetric Symmetric Liposome Phospholipid Cholesterol Cyclodextrin Virus Structure Lipid Rafts Cell Membranes Fluorescence FRET Immunoassays ELISA High Throughput Screening Systems Chromatography New Technology Implementation Formulation Bioconjugation Small molecule Preparing and characterizing small molecule trapped liposomal delivery system to increase sensitivity specificity in new and existing immunoassays ; Four employee invention disclosures submitted Designing , formulating , and characterizing small molecule trapped liposomes nanoparticles with modified functional surface . Biophysical biochemical characterization and stability evaluation of peptides , proteins , polymers , antibodies , bioconjugation , magnetic particles , liposomes , nanoparticles , etc . Developing immunoassays to detect specific antibody that interacts with antigen on automated high throughput screening systems Generating signaling molecule trapped liposomes to increase sensitivity specificity in new and existing immunoassays Optimizing reagent formulation , bioconjugation , buffer system , preservatives , blocking proteins , detergent , and paramagnetic microparticles Responsible for training associate scientists Trained for Six Sigma Black Belt Certification . Expert in design , fabrication , formulation , and characterization of delivery systems for drugs small molecules biologic therapeutics e.g. , model membranes , liposomes , liposomal nanoparticles , nanoparticles , artificial cell membrane , microspheres , PEGylated non PEGylated nanocomplexes , etc . ; Four Patents submitted Well versed in analytical method development and biophysical characterization of protein peptide liposome nanoparticle and their interactions bindings using fluorescence spectroscopy , AUC , NMR , HPLC , Dynamic Light Scattering DLS , and chromatography Senior scientist in early late stage immunoassay development with solid experiment skills and analytical instrument knowledge in the fields of immunology , biophysics , structural biology , biochemistry , drug development , and biomaterials Inventor of of dietary supplements for preventing arthritis ; Patent issued Inventor of liposomes with small molecule system to enhance sensitivity specificity in immunoassays ; Four patent applications submitted . Technologies : SLS DLS;AUC;NMR;FRET
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antibodies;carriers;peptides;proteins;characterization;screening;stability
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Director , Knowledge Systems Group ; Principal Scientist , Dept . of Data Sciences . Lead team of 30 Computational Biologists and Software Engineers in building software tools and products for cancer genomics research and precision cancer medicine . Principal Investigator for two NCI Moonshot Big Data Initiatives : the Cancer Immunologic Data Commons CIDC , and the Human Tumor Atlas Network HTAN Data Coordinating Center DCC . Co Principal Investigator for the cBioPortal for Cancer Genomics , the most widely used analysis and visualization tool for cancer genomics data . Spearhead development of MatchMiner , an open source clinical trial matching software platform for precision cancer medicine . Winner of 2016 Harvard Business School Clinical Trials Competition and 2017 BioIT Best in Show . Lead R D development for multiple clinical molecular assays , including OncoPanel NGS Assay and ImmunoProfile Multiplex Imaging assay . Key leader of the AACR GENIE Data Sharing Project corresponding author on first GENIE paper , published in Cancer Discovery . Key leader of the Intel Collaborative Cancer Cloud CCC Project to facilitate secure joint computation across multiple cancer centers . . As an innovative and accomplished bioinformatics leader , I have expertise in oncology and precision cancer medicine . I am highly skilled in software engineering , data architecture , databases , high performance computing , and cloud computing . As an excellent communicator , I am adept at building , leading , and mentoring strong performing teams to achieve organizational vision and objectives . Throughout my career , I have proven success in managing large portfolios of software projects , developing open source software , and executing informatics strategies to improve patient care . Areas of Expertise include : Data Analytics , Computational Biology , Cancer Genomics , Software Engineering , Bioinformatics , Scientific Computing , Agile Project Management , Machine Learning , Cloud Computing . Technologies :
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analytical scientist . . PhD in Sciences with specialization in Virology and practical experience in Somatic and Stem Cell Therapy Development . Domains of proficiency . Biochemistry : . o Flow cytometry ; . o Antigen capture ELISA ; . o Antibody capture ELISA ; . o Competition ELISA . . o Enzymatic activity measurement ; . o Western blotting ; . o Protein purification . Cell culture : . o Isolation and culture of primary mammalian cells ; . o Culture of mammalian and insect cell lines ; . o Recombinant protein production in insect cells ; . o 3 D cultures combined or not with biomaterials ; . o Cell differentiation assays . Molecular biology : . o RNA and DNA extraction ; . o RNA reverse transcription ; . o Real time RT PCR and semi quantitative PCR . Immunology and Virology : . o Seroneutralization tests ; . o Amplification of viruses in mammalian cell cultures ; . o Virus titration by the tissue culture infectious dose 50 TCID50 method and by plaque visualization . . Histology : . o Immunocytochemistry ; . o Histochemistry ; . o Immuno peroxidase monolayer assays IPMA . . Technologies :
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antibodies;enzymes;interaction
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. . I am studying membrane protein structure using Cryo Electron Microscopy . I am good at obtaining high quality monodisperse particles of membrane proteins . I worked in biochemistry and structure biology in the field of nucleotide excision repair , from which I mastered conducting p32 radio labeled nuclease assay .. Technologies : CryoEM
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membrane proteins;structure
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Staff Scientist . . I am currently a Staff Scientist in Thermo Fisher Scientific , where I have been working for three years this includes a short pre acquisition period at Affymetrix . I have also spent four months as a bioinformatics analyst at Complete Genomics and three years as a post doctoral scholar at UC Davis . My recent work involves both custom data analysis and internal systems and software infrastructure . I am a team player and consensus builder , highly efficient at collaboration across departments . I have strong programming experience , mainly in R Python , but with some exposure to other languages Perl , PHP , PSQL , JS , C . My work is driven by a relentless curiosity about the internal workings of computational , biological , and organizational systems . I am a driven , adaptable learner , with extensive experience resolving challenging analysis problems .. Technologies :
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Principal Scientist Bioinformatics . . I 'm a computational biologist with breadth of experience in processing and analyzing next generation sequencing NGS data to understand the mechanism of genetic variation across a genome within a single organism and depth of experience in the biological analysis of a single gene across many organisms . In particular , I have : Developed , optimized , validated and applied tools and workflows for processing and analyzing biological data To develop a better understanding of biological variation , built a computational pipeline to process analyze RNA seq data to identify variants and mutation patterns Introduced , evaluated and improved a Bayesian , population genetic , identification method that can assign unknown sequences to one of several known species groups Created a workshop for high school student to raise awareness of bioinformatics How would I describe myself Curious and possess a strong desire to learn Enjoy communicating complex concepts in the simplest possible manner Passionate about writing code to conduct analyses and working on problems that are going to matter Want to know more about me https : twitter.com mjjlou https : melaniejjlou.wordpress.com Email me at melanie.jj.lou AT gmail.com . Technologies :
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Postdoctoral Researcher . Postdoctoral Researcher at the IECB , Bordeaux , France Team ' Structural Biology of Biofilms ' led by Petya Krasteva Funded by ERC grant ' Biomatrix ' . From gene to structure I am a biochemist focused on membrane proteins : proteins make the workforce of the cell , they assume all the biochemical tasks essential to Life . among them , membrane proteins MPs play a special part : they are the gatekeepers , filtering the fluxes of matter and information in and out the cells . They play key roles in a number of diseases . as such , the structures and functions of the MPs should be well understood of as they represent perfect drug targets readily accessible on the cell surface however this is not the case . MPs are difficult to study : MPs are embedded in biological membranes made of phospholipids ; they interface with the fatty acid chains by displaying a specific hydrophobic surface the hydrophobic belt . to study MPs , they first have to be solubilized out of their native membrane and into detergent micelles . detergents are often not compatible with biochemical and biophysical assays additionally , detergents may disrupt the structure and hence the function of the proteins they solubilize . New tools for studying the drug targets of the future The recent years have seen the development of new biochemical and analytical tools that allow for better and faster structural characterization of the MPs : Nanodiscs NDs : the structural integrity of MPs is better retained in a membrane nanodisc than in a detergent micelle micropreparative LC LC : MPs usually come in smaller quantities than the soluble ones . LC is a powerful tool to better isolate MPs . cryo EM : MPs seldom cristallize Cryo EM is the new workhorse of MP structural elucidation . nanobodies nAbs : small nAbs recognize structural epitopes and lock MPs in different conformations , boosting tandem structure function studies Through my career see below I have developed the skills and tools required to push the boundaries of MP research , a field that requires technical excellence , focus , stamina and open mindedness . . Technologies : CryoEM;CD
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antibodies;membrane proteins;characterization;structure
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Senior Manager Global Regulatory Affairs CMC . . As Senior drug product coordinator , I am coordinating biopharmaceutical drug product formulation development and manufacturing activities . To be part of the development of a promising molecule into a launched drug is an exciting journey I have experience working within early phase up to phase I as well as late phase where submission for market and the following questions from the authorities have been in focus . Working with project management within Pharma is of course about getting a new product on the market , but also making a difference in interesting knowledge transfer processes externally and internally . It 's a pleasure being part of not only interactions with CMO CRO 's and project transfer to another company , but also internal transfers from Discovery to CMC and from CMC to Product Supply . Previously I have been working with project management within health and welfare technology , where I could use my educational background within pharmacy . My PhD thesis concerns protein aggregation , focusing on oligomerization and fibrillization in protein conformational diseases .. Technologies :
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antibodies;proteins;formulation;stability
|
Product Manager . Part of the global product management team of a family owned company , with the global responsibility for two stage oil lubricated rotary vane pumps , scroll vacuum pumps , vacuum measurement technology , and helium leak detection . . A nanoscientist specializing in cryo electron microscopy who now works in global product management for a family owned company , where he has global responsibility for two stage oil lubricated rotary vane pumps , scroll vacuum pumps , vacuum measurement technology , and helium leak detection .. Technologies : CryoEM
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Postdoctoral Researcher . Protein biochemistry , Structural biology , cryo EM . . Technologies : CryoEM
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proteins;characterization;structure
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Principal Machine Learning Scientist . . Detecting cancer before it is too late .. Technologies :
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Computational Biology Co op . . I 'm a project lead and software developer at Sandbox , studying computer science and biology at Northeastern University . I 'm currently looking for fulltime opportunities from July December 2022 , with passions in biotechnology and frontend fullstack web development . My areas of expertise include object oriented programming , front end development , and teamwork . Languages frameworks : React , Typescript , Node , Next , Java , MySQL , R , Vue , Python , Racket .. Technologies :
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Bioinformatics Architect . . . Technologies :
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Professor of Neurosurgery , Neurology , and Biomedical Sciences . Board of Governors Chair in Neurosciences endowed chair Direct the human systems neuroscience group in the department of neurosurgery . http : www.rutishauserlab.org . Systems Neuroscience , Electrophysiology , Learning and Memory , computational and theoretical neurosciene , Data analysis , Algorithm development , computational modeling , machine learning , clinical neuroscience . Technologies :
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Omics Data and Analytics Lead Director R D IT . . I am passionate about the patient , and I am motivated by making a difference to someone s life . I m inspired by great leadership and driven to deliver elegant solutions to complex problems that have the potential to improve human health . I enjoy using my skills to identify new insights offered by analyzing and integrating large multi omic data systems . My current goal is to continue to grow as a senior leader , developing and coaching junior staff and challenging them to execute and deliver in a quality manner . Leadership : 8.5 years people leadership via direct line and project leadership roles . Currently a manager of managers leading a function of 20 FTE split across data operations and software development . Lean Six Sigma Black Belt and champion , experienced influencer of other Snr Leaders . Understand the importance of the Voice of the Customer and Business to deliver appropriate data solutions . Experienced in storytelling with data .. Technologies :
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Professor . Fibrillation and aggregation of proteins . General folding and stability of proteins . Biophysics of membrane proteins , including stability and mechanism of insertion , folding and association in lipid bilayers and detergent micelles . Structure and mechanisms of antimicrobial peptides . This is followed using optical spectroscopy in combination with rapid reaction apparatus , protein engineering and mechanistic interpretation of the data . . University professor in Protein Biophysics . Particular emphasis on understanding molecular basis for cytotoxicity of protein aggregates , based on thorough understanding of the forces driving protein association with each other and with membranes . Therapeutic strategies to prevent undesirable associations are of particular interest . As complementary strategy also focus on formation of functional amyloid in bacteria . Specialties : Protein folding kinetics and thermodynamic stability followed by spectroscopic approaches and analyzed using linear free energy relationships . Dynamics of interaction with ligands detergents .. Technologies :
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idps;membrane proteins;characterization;engineering;stability
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Senior Scientist II . Fragment based drug discovery . SAR by NMR . . A biophysical chemist that specializes in protein NMR spectroscopy , molecular dynamics , and molecular modeling . Fragment based drug discovery .. Technologies : NMR
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small molecules;screening;structure
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Scientist Cryo EM . Cryo EM Structural Biology . A motivated interdisciplinary Scientist in the Department of Structural Biology at Genentech with 20 years of experience . I explore the structural and functional properties of therapeutically relevant proteins and their interactions with diverse ligands through protein expression , biochemistry and CryoEM . I collaborate with scientists throughout Genentech s Research and Development organization to advance both small and large molecule programs and fundamental research with over 25 publications .. Technologies : CryoEM
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proteins;small molecules;interaction;structure
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Senior Bioinformatics Scientist . . . Technologies :
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