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doctoral fellow . . . Technologies :
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Scientist II . At Apeel Sciences , we work with nature to improve access to quality , reduce waste , and ensure an abundant future for the planet . It s an exciting moment for the company , and we 're always looking for people interested in building with us Check out our open opportunities : https : apeelsciences.com careers . Experienced Research Scientist with a demonstrated history of successful frontier research in the biotechnology industry . Skilled in Bioinformatics , DNA Sequencing , Statistical Data Analysis , Microbiology , Molecular Biology , Linux , and R. Strong research professional with a Master of Science M.Sc . focused in Plant and Microbial Biology from the University of Illinois .. Technologies :
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Senior Scientist , Process Research . . Synthetic organic chemist with experience in pharmaceutical industry in fields of small molecule drug discovery , medicinal chemistry , synthetic planning and methodology development , multi step synthesis . Proficient in writing scientific publications .. Technologies :
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small molecules
|
Senior Scientist . . I am a passionate and committed medicinal organic chemist and have a strong track record over 6 year research experience in drug discovery field . I love bioactive small molecule design and synthesis for ADME profiling optimization and in vitro vivo efficacy in order to develop a good drug candidate . I have a strong background in structure based drug design and target oriented synthesis . Multi steps synthesis over a broad range of reaction types , conditions and scales mg to 100 gram . Synthesis , purification , and characterization of chiral compounds . Knowledgeable in drug discovery process from hit to lead candidates Mastering chemical analysis and structural characterization by LC MS , HPLC , and NMR instruments . Extensive experience in use of drug discovery tools to resolve troubleshooting in projects . Excel in multidisciplinary environments , collaborating with computational chemist , biologists , and DMPK scientists . Specialty includes : Medicinal chemistry , synthetic chemistry , structure based drug discovery , chemical library synthesis , and heterocyclic chemistry . I am currently looking for new challenge in drug discovery . Personal contact : chemwglee gmail.com . Technologies : NMR
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small molecules;characterization;developing
|
Head of R D . Managing and leading R D department with biologists , software developers , physicists , and electronics mechanical engineers Responsible for development of image based systems for automated cell analysis Innovation strategy and establishment of external relations Development of assays and computer scripts for numerical cell analysis . Molecular geneticist and R D manager with 20 years experience from academia and industry . Expertise in genetics , molecular biology , cell biology , protein expression and cytometry Ample experience with development of protein therapeutics and industrial enzymes Long track record of developing in vitro assays and cell based assays Strong skills in integrated and automated solutions Knowledge of transferring research projects from the bench into the marketplace Extensive experience with project management , team leadership , innovation strategy and attraction of external research funding Author of 25 publications several of them in high impact journals and patent applications Specialities Classical and molecular genetics Genetic engineering Micro arraying Development of in vitro and in vivo screening and selection systems Screening and selection of enzymes and protein variants Directed evolution High Throughput Screening Strain improvement Recombinant protein expression production Nucleic acid and protein purification and characterization Enzyme kinetics Antibody development and characterization Immunochemistry and fluorescence Fluorescent in situ hybridization Image and flow cytometry Image and data analysis Instrument development Software script development Higher education teaching and didactic learning R D project management Innovation strategy Establishment and coordination of external relations Attraction of external research funding . Technologies :
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antibodies;proteins;engineering;expression;screening
|
Head of laboratory Chemical Biology . . Expert in targeted protein degradation PROTACs , MGs for drug discovery . . Technologies : NMR
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molecular glues;developing
|
Cryo EM lab manager . . . Technologies : CryoEM
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Research Associate . . . Technologies :
| null |
SciLifeLab Fellow MIMS group leader . Responsible for the operative management of a structural biology cryo EM and infection biology research team of 8 members . Supervising and educating team members in performing technical or analytical research tasks , operating complex research equipment , establishing risk management plans , and providing support from initial experimental design to final scientific publication . Responsible for funding acquisition , documentation ELN , scientific publishing and outreach . . Scientist with leadership 3y , research 12y , and IT industry 5y experience in international settings . Skilled in project and team management , scientific writing , molecular and structural biology , biochemistry , and biophysics . Enthusiastic about using high performance computing and cutting edge scientific equipment for structural biology purposes . Avid outdoor adventure and sports enthusiast .. Technologies : CryoEM
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proteins;structure
|
Scientific Director , Head of Technical Integrator . Leading a fantastic team of Drug Product Technical Integrators . Team composed of scientific and technical experts responsible for integrating all DPD aspects of the vaccine product development and manufacturing from preclinical , early stage , late stage and transfer to commercial . . Industry pharmacist with extensive experience in the development of stable therapeutic and prophylactic peptide protein antibody and large variety of vaccine formulations in both pre clinical , early as well as late stage clinical phases . Specialized in the physical and chemical characterization of biologics and viral vectors using both standard and novel methodologies and techniques . Pioneered the field of high throughput screening of formulations and developed novel spectroscopic and microscopic methods . Worked on over 30 challenging projects as key member of a CRO ; several formulations are currently in phase 3 clinical studies . Experienced in CMC , manufacturing , fill finish and process development and leading transformational team s of sr scientists in complex matrix environment . Other responsibilities include : project management , IND IMPD and MAA regulatory filings , business development , acquisition of new projects , consulting , troubleshooting , due diligence . Specialties : Characterization , formulation , process development , adjuvants , adenovirus , poliovirus , MVA vector , viral bacterial vaccines , delivery systems , gene therapy , DNA RNA delivery , liposomes , LNPs , fill finish , GMP , manufacturing sciences and technology , scale up , tech transfer , freeze drying , high throughput screening , spectroscopy , peptides , protein and mAbs and mono multivalent vaccines . . . Technologies : SLS DLS;CD;FP
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biologics;characterization;developing;formulation
|
Bioinformatician . Tool development and analysis enabling personalized cancer vaccines . Bioinformatician developing tools to enable personalized cancer vaccines . During my PhD , I developed computational methods to study the effects of diet and genetics on mouse behavior and gene expression . Training pre PhD includes MEng BS degrees in computer science along with 5 years of professional software development experience . I want to apply both my technical and leadership skills to drug development . . Technologies :
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Senior Researcher . Mechanistic physiologically based pharmacokinetic modeling and simulation for model informed drug discovery . . Experienced researcher with a demonstrated history of working in research and development of mechanistic modeling of dynamical systems . Skilled in developing mathematical models and simulation algorithms for computational biology and biotechnology . Research professional with a Doctor of Philosophy Ph.D. in Computer Science from Universit degli Studi di Trento . . Technologies :
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Prof. . Biology . Research Undergraduate Education Postgraduate Education Specialties : Plant respiration Quantification of RNA realtime PCR , protein and coenzymes Transgenic plants Analyses of organell and membrane protein function . Technologies :
| null |
Senior Bioinformatics Scientist . . Senior bioinformatics scientist with extensive experience in cancer genomics , both in industrial and academic settings . GitHub : https : github.com martimij My specific experience includes clinical cancer data analysis for the 100,000 Genomes Project , association analysis of rare variants involved in metastatic prostate cancer predisposition , and mutagenesis mechanisms driving haematopoietic cancers . I have extensive experience in whole genome and exome sequencing , variant calling pipeline development for small and structural variants , evaluation of clinically relevant variants , analysis of FFPE and various experimental tumour samples , complemented by my original background and PhD in experimental molecular biology . As a co founder and previous long term board member of the educational non profit organisation Society for Out of Frame Education , I have also gained valuable management and leadership experience .. Technologies :
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Senior Research Development Scientist . Senior Scientist Drug Discovery Cellular Assay Development , screening and Mode of Action studies for small molecules therapeutic oligonucleotides and PROTACs in High Throughput Screening to Lead Optimization . Expertise in HT Flow Cytometry , FACS , Imaging , qPCR as well as HTRF , reporter gene , radioligand and label free assays with primary , iPS and recombinant cells . Mentoring junior scientists . Engaged and technically oriented scientist within drug discovery with an excellent problem solving attitude . I m a strong team player who can also work independently and enjoy working in cross functional teams and in multiple research projects simultaneously .. Technologies :
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molecular glues;nucleic acids;small molecules;developing;screening
|
Software Engineer Bioinformatician . Integrate protein 3D structure data and Proteomics data into UniProt protein database uniprot.org . Develop and maintain pipelines to build UniProt backend API services using Solr , Voldemort and Java etc . Setup DevOps pipeline to deploy UniProt services to VMs or Cloud . . Experienced Software Engineer and Bioinformatician with a demonstrated history of building complex pipelines to process big data in Biology . Skilled in Linux , Java , Perl , Python , SQL , LSF , GitLab , Docker , Kubernetes , Cloud etc .. Technologies :
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Associate Director , Data Science . . Data Scientist in the Life Sciences . Technologies :
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PhD Researcher Receptor Signaling and Biochemistry Group Martine Smit . ONCORNET network , Marie Sklodowska Curie Funding . GPCR CXCR4 and ACKR3 receptors involvements in cancer . Project management , from formalization to publication . Day to day team management . Two technicians and students , dedicated to my project . Successful European wide collaborations with labs and companies . Speaker and poster presentation in front of large audiences 300 attendees , monthly presentation in lab meetings . Determining phosphorylation profiles of the receptors upon stimulation . Determining kinases involved in the phosphorylation of those receptors . Nanobodies generation against phospho peptides in collaboration with Argenx , Gent . Compound screening . Kinetic characterization of molecules . Cell culture human cancer cell lines . BRET , HTRF , luminescence , radioactive binding , ELISA , FACS , immunofluorescence , western blot , impedance xCELLigence assays . HTRF fluorescence microscopy . Achievements : I successfully led a project on a challenging receptor ACKR3 from start to finish , resulting in a publication with novel data in a renowned journal Cells . I trained students to become fully autonomous . I co created a monthly journal club and presented numerous times in front of large audiences at conferences . . I joined the pharmaceutical industry in Basel early on in my career and successfully grew within this competitive field by working at Actelion , the biggest European biotech now property of Johnson and Johnson . Currently a Marie Curie PhD researcher in Amsterdam , in the field of GPCR signaling pharmacology , I am responsible of my own project in which I manage two technicians , and work in collaboration with other PhD students across Europe . Originally from France , I graduated with a Master 's Degree in Biotechnologies . I gained thorough multicultural experience , working in France , Switzerland and The Netherlands . After gaining practical knowledge of drug development in the industry and project management skills as well as theoretical knowledge during my PhD , I am now looking to transfer my portfolio of skills to a position within the pharmaceutical industry . . Technologies :
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antibodies;membrane proteins;small molecules;interaction;screening
|
Scientist . leadXpro is a lead discovery company focusing on membrane protein drug targets . We are committed to the application of biophysical and structure based methods for the discovery and optimization of next generation lead compounds . leadXpro s technology platform enables structural determination of membrane proteins where classical crystallographic techniques fail , unlocking structure based drug discovery for challenging targets . We capitalize on the knowledge regarding membrane protein structural biology and facilities of the Paul Scherrer Institute PSI with premium access to the synchrotron Swiss Light Source SLS and the Free Electron Laser SwissFEL . Core expertise beyond X ray include single particle cryo electron microscopy cryo EM . https : leadxpro . ch . . Technologies : Xray;CryoEM
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membrane proteins;small molecules;interaction;structure
|
Senior Scientific Associate . . An open minded Scientist PhD drug discovery oriented , with strong hands on expertise in cell culture and HTS compatible cell based assays with excellent organization skills . Experienced in the biotech industry and used to work in multicultural and interdisciplinary teams . Topics of studies : Assay Development Drug Discovery In vitro and in vivo Pharmacology . Cell based assays : 384 well format , second messenger release signaling pathways , cytotoxic and proliferation assays , cell transfection , lentiviral transduction , SiRNA . Cell culture : primary cells , recombinant mammalian cells , tissue slices , microexplants . Immunology : ELISA , Meso Scale Discovery , cellular functional assays , cytokine quantification , . immunophenotyping by flow cytometry . Molecular biology : RNA extraction , qRT PCR and PCR . Histology : immunofluorescence and image analysis by confocal microscopy . Small molecules screening using phenotypic screen . Animal handling : IP , IV , gavage , IT , necropsy , blood and tissue sampling . Technologies :
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Laborleiter . NMR Spektroskopie zur Strukturaufkl rung . Lab Team Leader for NMR Spectroscopy at BASF . PostDoc with Lucio Frydman at Weizmann Institute of Science . PhD with Harald Schwalbe at Goethe University . Passionate about Biophysical Chemistry and Magnetic Resonance Spectroscopy .. Technologies : NMR
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proteins;structure
|
Machine Learning Scientist . . Molecular biologist turned data scientist . Passionate about applications of AI in medicine and health tech such as patient monitoring , disease prediction , EHR analysis , medical imaging , and telemedicine . Prior work experience in clinical trials for 3.5 years . Postgraduate research on cancer screening tools using deep learning and computer vision . Currently working as a data scientist for project Fizzyo at UCL , aimed at improving care for children with Cystic Fibrosis . . Technologies :
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Associate Scientist . . . Technologies :
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Specialist . Experienced researcher in the field of In vitro pharmacology , with a main specialization in flowcytometry and Antibody Drug Conjugates . In 2011 I started working for Byondis . I first started as a technician for 1 . 5 year at Bio analytics within CMC and since August 2013 made the switch to the Research department where I 'm currently still working as a Specialist within the In vitro pharmacology group . Over the years I 've acquired extensive knowledge in the field of flowcytometry , both as a researcher on the practical aspects and as an operator being responsible for inhouse training of co workers and equipment maintenance . Within Byondis , I developed a broad knowledge on Antibody Drug Conjugates in general and all the different in vitro experiments that contribute to the preclinical development . Furthermore I also take a lot of interest in Immuno oncology to which my flowcytometric skills come in handy for the development of various assays . . Technologies :
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antibodies;characterization;stability
|
Process Development Scientist . 1 . Development and analytical characterization of monoclonal antibody formulations 2 . Design and execution of stability , stress , compatibility , risk assessment studies supporting formulation selection and shelf life stability 3 . Author and review CMC sections of regulatory submissions 4 . Techniques : Nephlometer , viscometer , Density meter , Osmometer , HIAC , MFI , Solo UV , MCE SDS , DSC , SE UPLC , Ion exchange UPLC . Highly motivated researcher with demonstrated background in Pharmaceutical and analytical development and Chemical biology , . PhD of Chemical Biology from USC . Publication record of 16 peer reviewed journal articles , book chapter , and abstracts in national and international conferences . Hands on experiences in most of formulation , analytical , and biological experiences . Ability to work independently , data analysis , problem solving along with analytical and creative thinking skills . Motivated and flexible to learn new techniques .. Technologies : DSC
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antibodies;formulation;stability
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Computational Biologist . . . Technologies :
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Scientist . Mode of Action studies on therapeutic antibodies qPCR technology platform leader . Enthusiastic and passionate molecular and cell biologist with extensive experience in cell based in vitro assays and a PhD. degree in molecular mechanisms of disease .. Technologies :
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antibodies;characterization
|
Research Fellow . Discovered peptide substrates that are specific to Dipeptidyl Peptidase 9 DPP9 , a key protein responsible for mediating inflammatory cell death through pyroptosis . Developed assays to detect enzymatic cleavage of small peptide fragments by specific enzymes as well as whole cell lysates . Developed aminopeptidase inhibitors that contribute to pyroptosis of cells by the build up of small peptide fragments . Synthesized a library of small molecules that , along with the small molecule DPP9 inhibitor Talabostat , showed synergistic pyroptotic cell death . Synthesis of biotinylated and fluorophosphate chemical probes for studying the process of pyroptosis . Synthesis of PROTACS Proteolysis inducing Chimeras targeting the degradation of caspases . . Gained cell culture experience with different cell lines , harvesting cell lines for lysates , western blotting techniques . . Performed high throughput screening with 384 well pintool instrument . . Obtained analytical mass spectrometry experience using a high throughput Rapid fire mass spectrometer . Synthetic Organic Chemist with over 10 years of research experience in multi step natural product synthesis , medicinal chemistry , small molecule library development , method development , compound characterization , SAR optimization . Diversified skills in chemical biology including enzymatic assays , chemical probes , cell culture work as well as adept at keeping neat record of data and presenting them to team members . Demonstrated ability to resolve key scientific hurdles with critical thinking and expertise and execute assignments in a timely fashion . Team player with excellent collaborative skills between inter disciplinary teams as well as proven mentorship skills in undergraduate and graduate research .. Technologies :
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molecular glues;peptides;proteins;small molecules;screening
|
Principal Scientist . . Passionate about translating cutting edge biomedical discoveries into novel treatments or therapeutics . Highly interested in gene therapy and viral vectors . As a research scientist , have more than 10 years hand on experience in Human Immunodeficiency Virus HIV , Viral Immunology , Antibodies , Adenoviral AdV vectors and Adeno associated viral AAV vectors , leading to 20 peer reviewed publications , 680 citations and 2 issued patents . Working on improving AAV vectors yields by screening new helper genes and engineering helper plasmids . Identified a novel helper gene that can improve the yields of AAV2 and some other serotypes by 100 . Led a project to develop gene therapy of HIV infection by using helper dependent Adenovirus vector HDAd carrying broadly neutralizing anti HIV antibodies bnAb in mouse models . Constructed multiple bi specific bnAbs with great potency . Optimized HDAd vectors carrying Luciferase or bnAbs , leading to over four months active gene expression in mouse model with a single intramuscular injection . Enjoy the pleasure of talking , working with people and making new friends . Volunteered in many non profit organizations , such as North America Maple Culture Center , Chinese Association for Science and Technology in Connecticut CAST CT , Career Network for student Scientists and Postdocs at Yale CNSPY . Served as reviewer for many scientific journals including Viruses , AIDS Research and Human Retroviruses , Archives of Virology and Cells etc . Enjoy life . Like modern drama , Tango , swimming , reading and poetry . Skills : Molecular cloning , Viral vectors lentiviral , retroviral and adenoviral vector , Antibody engineering , Small RNAs , Collaboration building BMS ViiV Healthcare , Team management , Communication .. Technologies :
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antibodies;biologics;carriers;engineering;screening
|
Sr Director of Bioinformatics . . Experienced bioinformatics scientist with a demonstrated history of driving projects from inception to product and employing disparate data to provide actionable insights and technological direction . Skilled in research and development , biotechnology , data engineering , and software engineering .. Technologies :
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Associate Research Fellow . Cryo EM . Image processing . Data Analysis . . .. Technologies : CryoEM
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Head of Computational Immunology , Priovant Therapeutics . . . Technologies :
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Associate Director Computational Biology . . . Technologies :
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Associate Scientific Director . Quantitative clinical pharmacology , M S , and drug development in oncology assets QCP lead for multiple programs spanning Ph 1 4 , including small molecule , oncolytic virus , and conditional bispecific T cell engager modalities . Current role in Clinical Pharmacology ; experience in gene therapy and small molecule drug development Expertise in mathematical modeling of biological networks , PK PD and mechanistic approaches , systems biology , and stochastic systems . Technologies :
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Senior Scientist Biochemistry and Assay Development . Team leader of a biochem lab with 4 technical assistants and a doctorate student Research topics : Enzyme development , Enzyme kinetics , Protein engineering Directed Evolution rational design , HTS assay development , Protein Purification kta , bioanalytics , project managment . Experienced Senior Scientist Group Leader with a demonstrated history of working in the research industry . Skilled in Protein Biochemistry , Enzyme Assays , High Performance Liquid Chromatography HPLC , Enzyme Kinetics , and Protein Engineering . Strong research professional with a Doctor of Philosophy Ph.D. focused in Biochemistry from Freie Universit t Berlin .. Technologies :
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enzymes;characterization;engineering
|
Analytical Specialist . . CORE COMPETENCIES : LC MS Small molecules , structure elucidation and quantification . Orbitrap , qTOF , triple quad and single quad HPLC Peptides Skyline , Compound discoverer , Biopharma finder . Massfontier , chemstation , masshunter Assay development and screening . Protein purification and characterization . Protein engineering by directed evolution primarily enzymes for baking Development , optimization and validation of Drug Substance processes . Support and troubleshooting to existing Drug substance processes . Preparation and review of registration documentation . Development , optimization and validation of Source Material processes Immuno chemical analysis . Project management Personal characteristic . Innovative , analytic , systematic , result orientated , Flexible and a team player . Technologies :
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proteins;small molecules;characterization;structure
|
PhD Student . . M.Sc . in Biochemistry . Structural biologist with interests in disease related receptor interactions , structure based drug design and rational protein design . Researcher of Polyomaviruses and their host tropism . Protein expression in E. coli and cell culture . Chromatography and protein crystallography . Big fan of x ray diffraction , data analysis , and protein structure modeling . Currently setting foot into cryo EM .. Technologies : Xray;CryoEM
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proteins;small molecules;interaction;structure
|
Principal Biologist . . Molecular biologist with experience in cell signaling , cancer and structural biology research . As part of Amphista Therapeutics , I focus on exploring the targeted protein degradation approach for the benefit of people suffering from numerous diseases . . Technologies :
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molecular glues;interaction;structure
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Scientist Cryo EM . . . Technologies : CryoEM
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structure
|
Research Technician . protein expression and purification cloning structural studies of protein nucleic acid complexes with cryo EM training undergrad students welcoming new team members organizing the lab , keeping track of orders , stocks . . Technologies : CryoEM
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nucleic acids;proteins;expression;structure
|
Machine Learning Scientist , Perturbational Biology . . . Technologies :
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Lecturer . . I am a charismatic and engaging educator and also , a talented and highly motivated scientist with a solid understanding and knowledge of pharmacology . I have spent about two decades in pharmacy , pharmaceutical , pharmacology , medical science , Ph.D. , MPharmSc , BpharmSc , and industry experience drug discovery , compound profiling , small molecule , cell based fluorescence assay , high throughput screening , multi well plates and electrophysiology . I have more than 10 years ' research experience in early stage drug discovery , safety pharmacology , drug target identification , ion channel as drug targets in cardiovascular , diabetes , and cancer , in vitro , in vivo , and human tissue pharmacology . I have been employed as a cultural liaison with the Center for Learning and Teaching , Dalhousie University , Canada . In addition , I have very strong therapeutic expertise within cardiovascular and diabetes , both clinical and research . Also , I have developed excellent customer facing skills in pharmacy . Importantly , I had the privilege to work on a drug discovery project for almost three years with a world class environment , Max Planck Institute . I have a wide range of teaching experiences three certificates in teaching in higher education as a lecturer , tutor , instructor and lab supervisor , and most importantly , incredible student feedback . Experience and skills : Health Care Coach , Communications and Presentations at International Level , OTC Sales Manager , Drug Discovery Research , Solid Knowledge of Therapeutic Pharmacology , Pharmaceutical Sciences , Clinical Trials , Writing , Publications , Expert in Drug Target Membrane Protein , Ion Channels , Calcium Signalling , Compound Profiling , Project Manager and Leadership , and Electrophysiology . I offer exceptional organizational and communicational skills , disciplined work ethics , and a team oriented mentality applicable to multiple therapeutic areas . Publications List : https : scholar.google.co.uk citations user IM3GEtoAAAAJ hl en . Technologies :
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membrane proteins;small molecules;screening
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Director of Biostatistics . . . Technologies :
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Clinical Lab Operations Improvements Lead . . Currently hiring in multiple roles Bfx , fluorescence microscopy , Mol Bio assay dev , automation , consumable manufacturing for my team . Reach out to work with a great group on cell free DNA based diagnostic screening I have spent the last 15 years combining biology , physics and computer science in research , commercial , and diagnostic settings , as well as personal projects . I 'm most excited about using these skills in a biomedical setting where I can have a direct , positive impact on human health . I am particularly interested in genomics and helping to deliver on the promise of personalized medicine . Specialties : Bioinformatics , Genomics , Electron Microscopy , C , Algorithm development , Teaching , Molecular Biology . Technologies :
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Bioinformatics Team Leader . . . Technologies :
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Senior Scientist . Senior Scientist High Content Screening . Project leader for High Throughput Screenings . . Specialist for High Content Screening Automated Imaging HCS ; Development of Biochemical and Cell based Assays for Pharmacological Screenings HTS ; Strong expertise in Cell Culture , Molecular Biology , Cytometry FACS Analysis ; Multi year experience in Electrophysiological Characterization of Membrane Proteins , Protein Chemistry , Product Specialist for Scanning Electrochemical Microscopes SECM , Microelectrodes and Accessories ; Experience on the fields of Sales , Project Funding and Organization , Customer Support . Keywords : Creativity , Interdisciplinarity , distinct Ability to work in a Team , very good Communication Skills , Mobility , Sociableness . Technologies :
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membrane proteins;screening
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MS T Downstream Purification scientist . . I have gained a lot of experience and skills in a wide variety of fields throughout my Ph . D. These skills include ; . Expression and purification of proteins from host cells . DNA manipulation of proteins to create better functional protein molecules . Lectin probe validation . Mammalian cell culture . In vitro cell probing using a wide variety of lectin and antibody probes . Flow cytometry . Fluorescent Microscopy . Throughout my 4 years of research , I have gained a wide variety of experience and knowledge around the glycobiology and cancer fields . . I have presented my work a number of times and won the best 5 minute presentation at the annual DCU school of biotechnology research day in 2017 . . Technologies :
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biologics;engineering;expression
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Postdoctoral Researcher . Profound expertise in . Engineering of novel bispecific T cell engaging antibody constructs Hemibodies . Bacterial expression of antibody constructs in shaking flask and 10 L fermentor Sartorius BiostatC . Antibody expression using suspension CHO cells in shaking flask and mini bioreactor system Eppendorf DASbox . Chromatographic purification of antibody constructs kta system . Design and implementation of T cell killing assays . Antibody screening Nanobodies , scFvs and DARPins . Knob into Hole antibody format design . Transposon mediated gene transfer PiggyBac system . Supervision Mentoring of Bachelor , Master , MD and PhD students . Public relations work crowdfunding for cancer research . Patent writing . . Technologies :
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antibodies;engineering;expression;screening
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Senior Scientist . . I am investigating the application of targeted therapy using antibodies for targeting and drugs cells for treatment . I am in particular interested in antibody fragments from heavy chain only antibodies , indicated as VHHs or nanobodies . Technologies :
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antibodies;interaction
|
Computational Biologist . . . Technologies :
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Bioinformatics Analyst . . . Technologies :
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Sr . Director , Bioinformatics . . In the recent years I have been a bioinformatics scientist , software developer , and consultant . I have a strong background in both Computer Science and Biology and have had extensive experience working with professionals and academicians from both fields . I have done research , analysis , and developed software in both Windows and Unix environments using languages such as Perl , Python , R , Matlab and C . Specialties : bioinformatics , next generation data , software engineering , perl , matlab , microsoft c , research , software development and testing , statistics , data analysis and processing , project management . Technologies :
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Ph . D Student . . 5th year PhD candidate in chemistry at Case Western Reserve University . I will be defending my dissertation in the spring of 2023 . I am studying RNA protein interactions using comprehensive biophysical methods including NMR , ITC , cryo EM and DMS MaP seq . I am currently working on the human coronavirus OC43 . . Technologies : CryoEM;ITC;NMR
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nucleic acids;proteins;interaction;structure
|
Scientist I . Lab automation screening . R D scientist with 11 years experience in academia and industry . Proficient in molecular biology and mammalian cell biology , most recently specialized in methods for targeted protein degradation and mRNA delivery . Fully capable of conducting research work strategically and independently , driven by creativity and strong problem solving competences . Passionate about building innovative technologies to bring medicines to patients .. Technologies :
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molecular glues;interaction;screening
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Science Specialist . . As an undergraduate student at Stuttgart University , I fell in love with electron microscopy . Starting as a PhD student at EMBL Heidelberg in the team of Dr. Yannick Schwab I got fascinated with the combination of light and electron microscopy and its potential , especially looking at 3D rather than just 2D. Correlative light and electron microscopy CLEM experiments uniquely provide an accurate link between the imaging of individual living cells and their 3D ultrastructure . However , they generally suffer from a low throughput . The major hurdles include tracking the object throughout the different imaging modalities , the tedious procedures for sample preparation and the lack of automation in the data acquisition by electron microscopy . Therefore we developed a workflow to select a subpopulation of cells in light microscopy and a software to target tens of them in an automatic manner in the focused ion beam scanning electron microscope FIB SEM for volume acquisition . Fluorescence microscopy is utilized to screen for specific phenotypes and electron microscopy to look at the corresponding ultrastructure . By combining CLEM and automated serial imaging , we intend to dramatically improve the throughput of CLEM experiments . During my time at EMBL , I was lucky to be able to collaborate with different groups inside and outside Germany for different correlative light and electron microscopy projects looking for example at the nuclear envelope assembly at the end of mitosis Ellenberg lab , EMBL or how to combine on chip light microscopy with volume EM imaging of liver cells Ahluwalia lab , The arctic university of Norway . I quickly realised that I am extremely interested and passionate about various projects , using and developing new techniques to answer different biological questions . Therefore I wanted to continue working in a multi user environment . I consider myself lucky to now currently work as a post doc in the Electron Microscopy Core Unit at the Max Planck Institute of Experimental Medicine in G ttingen . Besides working on high resolution volume EM imaging of myelin mutants and the implications for axo glial interactions , I could also gain more experience in the very fascinating field of Cryo FIB SEM volume imaging and lamella preparation . Continuing in method development and different cryo electron microscopy methods I have joined the EM team of the new Imaging Center at Embl .. Technologies : CryoEM
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structure
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Computational Biologist Bioinformatician Postdoctoral Research Associate . I am located at the Cambridge Centre for Proteomics http : proteomics.bio.cam.ac.uk in Kathryn Lilley 's group at the University of Cambridge . My main research area involves the design and development of software and computational pipelines for the analysis and visualisation of high throughput mass spectrometry MS based proteomics data . My work ranges from the processing of low level raw proteomics data , through to protein aggregation , differential abundance analysis and the generation of sub cellular proteome maps for species ranging from single cell organisms to complex mammalian cell lines . Core elements of my research include the development of novel machine learning methods for 1 differential protein localisation following treatment , for example drugs and stimulus , 2 novelty detection methods for the identification of unannotated sub cellular complexes , and 3 for the integration of heterogenous data , for example transcriptomics data , imaging data etc . In terms of biological applications , these methods have been used to infer sub cellular spatiotemporal changes in the proteome for different species and cell lines I am an R and Bioconductor package developer and contributor for a number of computational proteomics packages . I am also principally involved in the implementation and maintenance of a suite of interactive visualisation tools using R Shiny for the dissemination of spatial maps for both in house use and for the cell biology and proteomics communities . . Computational Biologist located at the Cambridge Centre for Proteomics CCP , University of Cambridge . My main area of research focuses on computational analysis of high throughput quantitative spatial proteomics data and development of new machine learning tools and R packages .. Technologies :
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Head of Service , Clinical Computational Research Informatics . . Specialties : Python , Perl , SQL , PL SQL , JavaScript , Bash , OpenStack Cloud . Technologies :
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Staff Scientist , Bioinformatics . Gene expression and methylation R D . : : More than six years of experience in Python programming , R programming , Bash Scripting , and Next Flow pipeline . Capable of making reproducible codes and easy to use Python and R packages . Routinely use NumPy , Pandas , Scikit learn , Scipy , and many other packages for data code development and data analysis . Also , have working knowledge in Perl , HTML , CSS , and Javascript . : I have been analyzing NGS datasets from TCGA , ICGC and many other sources to define somatic mutational signatures using single nucleotide variants SNV , copy number variants SNV and structural variants SV . We use the mutational signatures to associate cancer risk factors with different types of cancer and assessment of targeted therapeutic approaches . I also have the experience to use different genome analysis frameworks such as GATK and Dragon Bio IT platforms as well genome analysis tools BWA , Samtools , FastQC and variant callers Mutect2 , Strelka2 , VarScan , MuSE . : Developed tools that are capable of doing parallel computing using multiprocessors and multithreading . Also , implement a message passing interface MPI in python to use CPUs from separate nodes in a parallel fashion . Routinely implement GPU enabled coding using PyTorch and TensorFlow frameworks . : Have excellent command and understanding of both supervised and unsupervised machine learning algorithms . Hands on experience with SVM support vector machine , Logistic regression , Random Forest , deep learning algorithm , Non Negative Matrix Factorization , PCA , Kmean , and Hierarchical Clustering . Also , have good knowledge of algorithms for DNA Sequencing . : Comprehensive experience in using Amazon Web Service AWS . Perform large matrix operation based data analysis in both CPU , GPU , and memory optimized instances . Quite familiar with storing , send , and receive data in S3 buckets . Also , routinely use other cluster supercomputers at UC San Diego . : Have comprehensive and in depth knowledge of machine learning , next generation sequencing NGS , molecular biology , immunology , cancer genomics , and cell signaling pathways . . Technologies :
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PHD Candidate in Protein science Structural biology . Structural and functional properties of copper transporters . In general , details always grab a lot of my attention and when it comes to science , I have a huge interest to figure how exactly proteins are and function . I am extremely fascinated by the methods allowing us study the function of proteins and I feel lucky for being able to do so since 2015 . In this context , I have become experienced with both worlds of soluble and membrane proteins produced in small or large scales in yeast and bacterial systems . I am skillful in up downstream processes of protein characterization ranging from production of mutants to purification and functional studies .. Technologies :
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membrane proteins;characterization;interaction;structure
|
Research Laboratory Manager Dept . of Cardiovascular Medicine . Designing and conducting murine inhalation toxicity testing using tobacco and e cigarette products . Evaluating the toxic effects of tobacco and e cigarette products in the cardiovascular system , specifically in transgenic mice . Areas of technical expertise : rodent mouse colony management , animal husbandry , molecular biology , histology , immunostaining , microscopy , and image data analysis . Lab administrative responsibilities : Lab inventory organization and maintenance , Lab safety coordinator , Lab protocols development and maintenance , Lab supplies ordering , Lab equipment maintenance troubleshooting , Coordinating with facilities vendors for general technical lab support . Proficient in GLP safety regulations Molecular and Cell biology experience : DNA RNA isolation from tissues and cells , PCR , RT PCR , qPCR , vector design , gene cloning , and expression , ELISA , MTT assay , RNAScope , nanoString Microbiology experience : Proficient in establishing bacterial cell cultures both aerobic and anaerobic ; Time kill assays with antibiotics ; Minimum Inhibitory Concentration MIC determinations Molecular Virology experience : Isolation and growing bacteriophages from clinical samples and the environment Histology experience : Processing samples FFPE , Cryosections Immunology experience : Immunostaining Immunofluorescence IF and Immunohistochemistry IHC Microscopy experience : Brightfield , Fluorescent , Scanning Electron Microscope SEM Small animal handling mice injections : Intraperitoneal , Tail vein , Oral gavage ; Mice colony management Laboratory management inventory maintenance ; instrumental troubleshooting ; Lab safety coordinator Preparation of media , buffers , and reagents Experience in bacteria infections related research and studies Skilled with computer application packages : Microsoft Office and Mac ; Statistical tools : GraphPad Prism ; Image analysis tools : Fiji ImageJ , Cell profiler , QuPAth , Aperio ImageScope ; R programming Excellent oral and written communication skills SOP , documentation Adept at planning and meeting deadlines . Technologies :
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Postdoctoral Researcher . Dong group project management . Scientific research activities : Cryo Electron Microscopy . Transmission Electron Microscopy . Mammalian cell lines cultivation . Advance microscopy technics FRET , FRAP , FLIM . Molecular biology methods . Basic and advanced biochemical methodologies . Advanced spectroscopy methods CD , LiSSP , DSF , nanoDSF . Flow cytometry . 3D modelling Chimera , PyMol . Statistical analysis . Mass spectroscopy . Prokaryotic and eukaryotic protein expression systems . Classic and chromatographic protein purification . Bachelor , Master and PhD students ' tutoring . . Postdoctoral scientist with expertise in virology , antiviral development , biochemistry , structural biology , and immunology . Strong project and team manager with a proven ability to meet tight schedules and flexibility to work under pressure with tight deadlines and late hours . Excellent communication and teaching skills with an emphasis on science dissemination and interdisciplinary collaborations .. Technologies : CryoEM;DSF;FRET
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proteins;characterization;structure
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Research Scientist II . 1 . Cancer Genomics Performed pan cancer epidemiological genomics analysis . This work answers a surprisingly unanswered question about epidemiological incidence of cancer associated mutations Nature Comm . 21 , KMCO 22 Collaborated with medical doctors assisting histological and locational annotations of samples from 139 whole exome sequencing studies including 20,000 patients . Processed epidemiological clinical data of cancer cases in the US and implemented automatic annotations combining histological and locational clinical data 7 million patients , 670 cancer types . Created a map based on conditional probabilities to reweight sequencing data by epidemiological distributions . Created error estimation and propagation methods to simulate errors induced by random variations in input data . Other genomic projects : Mitochondrial OXPHOS signaling in RNAseq patient data . 2 . Systems biological modeling Used mathematical models of RAF protein and RAF inhibitor interactions to predict resistance mechanism to next generation drugs . Used theoretical physics tools to completely solve active RAF as a function of parameters such as RAF dimerization constant , RAF drug interaction constant and concentrations of RAF and drug . Created code in Mathematica to validate hand derived expressions and perform analytic sensitivity analyses . Created numerical code in python to simulate more complex models integrating clinical , biophysical and biochemical experimental data . Other protein signaling in silico projects : NOTCH signaling , EGFR signaling , RAS signaling . Created and implemented non convex clustering algorithms to search for related computational mutants representing novel protein interaction strategies among co mutations of NF1 a tumor suppressor and RAS . 3 . Developed methods for and performed biophysical RAF drug interaction measurement using thermal differential scanning fluorimetry TSF DSF . . Computational Biologist with an extensive background in theoretical physics and a desire to use quantitative techniques to study and treat human disease . Experienced in integrating data from several sources such as biophysical assays , sequencing , molecular biology assays and clinical patient data . The evaluation of genomic changes and their impact on protein signaling in normal and diseased conditions so as to inform therapeutic strategies and side effects is of particular interest .. Technologies : DSF
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Senior Research Scientist Associate Director Lead Investigator Research Associate . Hired as research associate and promoted into role charged with establishing and leading interdisciplinary research center for Harvard Medical School s affiliated teaching hospital . Forge and sustain relationships across the enterprise to further R D objectives and align efforts with institutional goals . Establish and manage vendor relationships for innovative technologies via engagement programs and sponsored research agreements . Charged with recruiting , managing mentoring teams of up to 10 , prioritizing tasks , projects works collaboratively with internal research computing teams . Built research center s robust technical infrastructure from the ground up : evaluate , purchase , install and support 6 functional MRI systems on 6 Siemens or GE 3 T MRI scanner sites ; participate in multiple PET ligand evaluations , studies data analysis ; took accountability for full alignment with institution wide data architecture with streamlined operations ; lead modernization of computing systems enabling diverse research studies to collect and investigate large data sets ; architected first of its kind integrated eye tracking recording solution for functional MRI studies , collaborating with multiple key vendors of hardware software to steer development ; implement plans for health safety compliance , laboratory administration ; manage multiple projects in complex technical facilities for both clinic research studies . Promoted and adopted intuitive best practice approach solutions from NextGen GWAS multi omics data analytics in diagnostic prognostic predictive applications in Oncology and Immunology into the field of functional brain imaging and CWAS Connectome Wide Association Study data analytics in CNS diseases . Directed and nurtured an interdisciplinary STEM team , in coordination with directors of labs divisions , to adopt , improve , and innovate data science solutions that integrate multiple disciplines ahead of the rest of the field . . Thought leader and data science pioneer with significant track record for translating AI ML algorithms and advanced statistics capabilities for real world applications . Recognized as creative , resourceful , integrative expert in extracting and analyzing patterns from high dimensional datasets to shape and deliver predictive and optimized data solutions in translational precision medicine . Collaborative medical imaging director who partners across disciplines and gains executive level buy in for quantitative software tools in advanced in vivo neuroimaging , directs productive collaboration relationships with industry leading vendors , serves as expert in planning , designing , optimizing conducting MRI PET imaging experiments , quantitating interpreting imaging data . Award winning researcher and instructor dedicated to train and motivate the next generation of data scientists and imaging researchers . Convene diverse stakeholders to unlock previously untapped avenues and pave way for cutting edge solutions . SELECT ACHIEVEMENTS AREAS OF EXPERTISE : Spearheaded groundbreaking solution to drive major advancements in developing first of their kind , statistical , data driven diagnostic tools for guiding the treatment of CNS disorders . Established led interdisciplinary neuroimaging research center to enable development delivery of cost effective , successful diagnostics treatments in CNS medicine . Earned Mass General Brigham Excellence in Innovation Award 2X and Pillar Award in Research Innovation , with 60 journal publications . Led imaging data science efforts hands on executions as a core team member on 20 federal institutional projects , with deep understanding of imaging techniques across multiple modalities , demonstrated ability to collaborate with researchers of diverse background , consistently delivered analysis results with significantly higher performance than state of the art packages in the field . Created best practice approaches for optimized data acquisition , biomarker discovery automated informatics reporting and data visualization pipelines based on MRI methodology , resulting in 4 patents . Medical Imaging Statistical Analysis Large Scale Data Analytics Network Neuroscience Computational Biology Strategic Planning Execution Excellent Problem Solving , Collaboration , Communication Writing Skills Software Development Data Visualization Programming Skills C R SQL Python Cloud Computing Cross Functional Projects Program Management Industry Experience Academia Industry Engagement . Technologies :
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Biochemistry PhD Candidate Kollman Lab . I study the dynamic assembly of enzymes involved in purine biosynthesis through the use of cryo electron microscopy cryoEM and other biophysical techniques . . I will graduate with my PhD in Biochemistry in June 2022 focusing on using protein purification , cryo electron microscopy , and biochemical assays to define allosteric regulation mechanisms . I have performed in vitro characterizations of mutations that lead to human blindness and developed an animal model to study the molecular mechanism of disease . During my PhD I have lead a variety of projects , mentored 7 graduate students , and established lead a new collaboration that has been supported by multiple grants resulted in a publication . My scientific expertise includes : Curious and highly motivated collaborative scientist , supported by a strong publication record with multiple interdisciplinary collaborations Significant experience developing recombinant protein expression purification protocols Extensive use of cryo electron microscopy cryo EM and model building Experienced leader and has trained 7 graduate students 2 undergraduate researchers . Technologies : CryoEM
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enzymes;proteins;characterization;expression;structure
|
Teacher . . Ultrastructural sudies of rod photoreceptor nuclei from SCA7 mouse . The spinocerebellar ataxia SCA7 is a polyglutamine polyQ expansion disease in which the retina is affected and results in blindness . Ataxin 7 ATXN7 , the protein mutated in SCA7 , is a subunit of the hSAGA complex . The hSAGA coactivator is known to regulate transcription , notably through histone acetylation mediated by the GCN5 histone acetyltransferase . In SCA7 mouse models the overexpression of polyQ expanded ATXN7 in rod photoreceptors induces a progressive retinal phenotype resulting in rods dysfunction with electrophysiological , histological and transcriptional abnormalities leading to a dramatic alteration of the rod nuclear architecture . Specialties : Electron Microscopy of rod photoreceptor nuclei Preparation of retina samples for Electron Microscopy : Retina dissection High Pressure Freezing Freeze substitution Ultramicrotomy Electron Tomography of rod photoreceptor nuclei tilt series acquisition FEI soft reconstruction Expect 3D Immunogold labelling on ultra thin cryo section with the Tokuyasu method Cryo Electron Microscopy of Vitreous Section cemovis . Technologies : CryoEM
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Senior VP Research . . I am an experienced leader and drug discoverer who has worked in the pharmaceutical industry for over 20 years , following 10 years in academia . As Head of Oncology Drug Discovery for the Novartis Institute for Biomedical Research NIBR , Basel Site , I have overseen significant part of NIBR s global oncology drug discovery portfolio from target discovery to clinical development . While . working in the Oncology Drug Discovery , I have initiated and supported the development of drugs like Glivec , Tasigna , Afinitor , Midostaurin , as well as PI3 K inhibitors and many other signal transduction inhbitors that are in Phase I II III or preclinical development . . In the past 6 years , working in the Expertise Platform Kinases at Novartis Basel which I initiated and implemented , I focused on protein kinases as a target class for various therapeutic indications leading a group of scientists dedicated to integrated lead finding , profiling , project support and project management spanning oncology , immunology , inflammation , muscle , neuroscience , infection and neglected diseases . I have a long standing experience in drug discovery from early hit finding to H2L to lead optimization to introduction to clinical trials . I have worked successfully in various oncology programs in the pharmaceutical industry Ciba and Novartis for over 20 years and have a broad skill set in drug finding as well as managing people . . Technologies :
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proteins;small molecules;interaction;screening
|
Assoc . Scientist . . Over the four years of working in the industry , I have supported the development of a range of innovative drug modalities such as small molecules , PROTACs , engineered peptides proteins , antibodies , RNA based therapies as well as various drug delivery approaches across many therapy areas . In my recent position in the Immunotoxicology Team at AstraZeneca I have gained extensive experience in studying immune related questions to aid pre clinical and clinical development of drug candidates utilizing a diverse set of assay technologies . My main interest is in the field of immuno oncology . . Technologies :
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molecular glues;proteins;antibodies;nucleic acids;developing;engineering
|
Research Assistant II Biophysics . Maintain and troubleshoot Talos Artica , Titan Krios , and Glacios cryo electron microscopes . . I have planned for a career in scientific research , laboratory management , and microscopy photon and electron . But life takes you in whatever direction it chooses and I also have experience in C and SQL software development .. Technologies : CryoEM
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structure
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Bioinformatics Scientist . Led and implemented the entirety of the data analysis for two large scale random insertional mutant libraries in Chlamydomonas reinhardtii ; designed and implemented mutant screen sequence analysis pipelines ; advised other lab members on choosing statistical methods and experiment designs for their projects and performed statistical or other computational analyses for them ; co first author on two papers . . Bioinformatician with 10 years of data analysis and python programming experience in academic labs . Looking for new bioinformatics job opportunities , particularly in academia .. Technologies :
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Scientist . . CMC lead for Developability assessment lead selection and biophysical charcterization scientist with several years of experience in industry and academic research in the fields of Protein Chemistry , Biophysics and cancer biology . Broad research experience in both biophysical and analytical techniques . Experience in scientific team management and collaboration , strategic thinking and planning , as well as project based management skills . Key interest in technology innovation , including development of new technologies , cancer research , formulation development and stability studies . Always curious about what drives human development and learning . . Technologies :
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proteins;characterization
|
Senior Principal Scientist . . Back at Amazon working on optimization problems at scale on Amazon NA consumers .. Technologies :
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Associate Professor . Principal investigator of research group comprising 10 scientists at various career stages . Part of interdisciplinary consortia PROMEMO memory and BOUNDLESS membraneless organelles . Teaching class on Physical Biochemistry , Proteins and their Interactions and Biomolecular Structure and Function . My research focus on dynamic and disordered proteins broadly defined . I am an expert on intrinsically disordered proteins , that is proteins without a fixed tertiary structure . Can be reached at : magnus mbg.au.dk We study the molecular mechanisms of disordered proteins , as well as their involvement in health and disease . We are trying to develop synthetic disordered proteins for applications in biotechnology , currently focusing on making new membrane less organelles for use in biosynthetic cell factories . My technical expertise lies in quantitative biophysics and biochemistry . We use a broad range of experimental techniques to characterize the activity , stability , structure , and interactions of proteins . I am the scientific coordinator of the Biophysics Core facility at the Department of Molecular Biology and Genetics , and serve as the point of contact for external users who wish to use our equipment . I am open to both academic and industrial collaborations within my overall field of expertise . Jeg formidler molekyl rbiologi p dansk med fokus p hvordan livets molekyler fungerer . Jeg holder foredrag under titlen Hukommelsens molekyler med udgangspunkt I forskningen ved grundforskningscenteret PROMEMO . Foredraget kan books under Forskningens D gn eller ved at kontakte mig direkte .. Technologies :
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idps;proteins;characterization;engineering;interaction;stability;structure
|
Bioinformatics Scientist . . Bioinformatics and machine learning scientist using computational statistical methods for analyzing sequence data . Working with next generation sequencing data in the context of germline and somatic variant calling , genotyping , and forensics , and developing software in these contexts . Expert in probability models , with applications in variant calling , forensics , phylogenetics and evolutionary modeling . Very strong background in machine learning and pattern recognition , including probabilistic graphical models , Bayesian statistics , dimensionality reduction , classification and clustering algorithms , and reinforcement learning . Excellent mathematical , statistical and computing skills . Development of scalable methods for large scale next generation sequence analysis . Experience analyzing diverse combinations of data sources . Programming : C C C , Java , Python , Matlab Octave , R , Perl . Fluent in linux command line and shell scripting tools . Experience with MPI and High Performance Clusters . Established track record in collaboration and mentoring . Developed several popular selection analysis tools available on the public web server , Data Monkey www.datamonkey.org , receiving over 10,000 page views per day . Extensive and highly cited publication list in bioinformatics computational biology . Also trained in speech recognition , natural language processing , spoken dialogue systems and digital signal processing , with highly cited publications in this area . Winner of the TWAS AAS Microsoft award 2010 for Young Scientists , recognizing out standing research in computer science conducted by African scientists that has , or promises to have , an impact in the developing world . . Technologies :
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Senior Research Scientist . My job entails characterizing the biophysical properties of proteins and peptides in the earliest phases of research in the areas of diabetes and obesity . I work in multiple concurrent projects as a member of diverse teams where I contribute as an expert in biophysics , formulation pre formulation , physical stability , and characterization of protein and peptides . Current responsibilities include coordination and project management of department and area wide initiatives concerning automation and data science . . Biophysicist with 10 years experience with proteins , formulation , and biomolecules . Widely published . Emerging leader , passionate about facilitating and enabling excellence in teams working on complex and fascinating science challenges . Pushing the field forward with new measurements and analysis , towards new predictions and insights .. Technologies :
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peptides;proteins;characterization;formulation
|
Principal Bioinformatics Scientist . . Computational scientist with 15 years of experience in algorithm and assay development . I like to work on research and early stage product development . I have provided leadership on projects to improve assays and develop pipelines for products that save lives .. Technologies :
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Senior Scientist . Department Safety in the Food Chain Unit 84 , Feed and Feed Additives , led by PD Dr. Robert Pieper and Department Exposure Unit 33 , Epidemiology , Statistics and Mathematical Modelling led by PD Dr. Christine M ller Graf I am currently working with computer modeling for quantitative risk assessment of chemical contaminants in the food chain supply chain . My work spans all the way from programming numerical algorithms for computer simulation to translating scientific findings to make them useful to government officials assessing and managing chemical risks . I have many years of experience planning , leading and managing research projects involving several team members . . Trained by physicists . Anchored in chemistry . Enamored of biology . My career focus is on scientific research using computer simulations and mathematical modeling to understand complex systems at different time and space scales . I am most at home solving problems of medical , nutritional or environmental significance . Techniques : Pharmacokinetics , toxicokinetics and compartment models Scientific computing and numerical mathematics Information theory and statistical methods for data studies Molecular dynamics simulation and statistical mechanical modeling Examples of applications of my work until now : Toxicokinetics of chemical pollutants in feed and food Transfer modeling for undesirable substances in feed and foodstuffs Thermodynamics of protein folding and receptor ligand binding Conformational entropy estimation of beta amyloid aggregation in neurological diseases Calculation of dynamic modulation of pigment transition energies in photosynthesis Specialties : Development of modeling and simulation algorithms Thermodynamics and kinetics of complex systems Computer simulation of physical chemical biological systems . Technologies :
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Staff Bioinformatics Scientist . . . Technologies :
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Doctoral Researcher . PhD thesis : ' Programmable DNA Origami Shell Platform for Virus Neutralization ' Focus on : Molecular design of artificial DNA nanostructures mimicking virus capsids with applications for virus neutralisation , drug delivery , and vaccination Characterisation of DNA nanostructures and proteins using cryogenic electron microscopy cryo EM , single particle electron microscopy tomography , helium ion microscopy HIM , enzyme linked immunosorbent assay ELISA , fluorescence resonance energy transfer FRET assay , and interferometric scattering microscopy iSCAT Molecular modelling with all atom and coarse grained molecular dynamic MD simulations Customised scripts for the design and analysis of DNA nanostructures Python , Bash , Igor Interdisciplinary collaborations including virologists , biochemists , and theoretical physicists : Project manager in the EU Horizon2020 research consortium VIROFIGHT : coordination calls , organising general meetings , and preparing deliverables with set deadlines Conducting DNA nanotechnology workshops for PhD students and postdocs at Brandeis University , Waltham Boston MA , USA Presenting at international conferences oral and poster My PhD research was awarded the ' Nano Innovation Award 2021 ' CeNS . . Technologies : CryoEM;FRET
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carriers;proteins;structure
|
Neuroinformatics researcher software engineer . . . Technologies :
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Industrial Liaison Engineer . . I am an enthusiastic and collaborative biocrystallographer . I always had a strong interest in developing better scientific methods and experiments to meet other scientists needs . This led me to be the scientific contact for the ESRF industrial clients of the MX , BioSAXS and Cryo EM end stations .. Technologies : CryoEM
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Principal Bioinformatics Scientist . . I lead a Bioinformatics team working to significantly reduce greenhouse gas emissions . Using Systems Biology and the latest omics approaches , we engineer microalgae that use sunlight and carbon dioxide to produce biofuels and other molecules of high environmental impact . I split my time between hands on work at the computer and coaching mentoring team members pursuing a variety of tasks both in silico and at the lab bench . My primary interest is using computers to solve the most difficult challenges in biology . I have experience with the tools and methodologies for extracting the most knowledge from diverse data , including DNA sequence long short reads , whole genome , organelles , amplicons , RNA Seq Illumina PacBio , metagenomics shotgun amplicon , networks , and metabolic modeling . On the infrastructure side , I rely on technologies like Python , R Shiny , Docker , AWS , and SQL to rapidly push bespoke data analyses to scientists . Previously , I have worked on a wide variety of projects , including xenotransplantation , agricultural pest prevention , genome editing system discovery , synthetic biology software , and the application of high throughput proteomics toward human diseases CF and diabetes .. Technologies :
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Senior Application Specialist Consultant trainer , EMEA CIS : Chromatography : DSP , Bioprocess . . Senior Consultant , Trainer and Application Specialist for whole portfolio of Purification chromatography products , for EMEA Russia CIS Turkey for customers scientists of pharmaceutical laboratories . Downstream Processing development and Bioprocess . In charge of the scientific on site and remote technical support : Consulting , training , protocol optimization , troubleshooting : on packing purification protocol , column packing expert . Lab , pilot production scales of biotech and pharma companies . In External internal training seminars hands on technical demonstrations on resins products . Besides customers training , intensive internal training of colleagues : Continuous punctual training of the whole european and asian purification sales team , 1o1 trainings on global sales cell culture team , training and close mentoring of new hired technical application support colleagues product and application related training Technical training of the european technical hotline team purification Regular soft skills and troubleshooting Trainings given to application support colleagues from diverse divisions : behaviour and logical thinking training to enhance relationship and support given to customers . Full execution delivery and complete organisation of the training : planning , lectures content set up , complete logistic detailed schedule , material lab set up , level assessment , theory training practical exercises , brainstorming , management of expectations questions , application consulting . . Downstream Processing of cytosolic and membrane proteins : Biochemistry characterisation , membrane filtration , purification by Chromatography HPLC : IEX RPC HIC MC AC SEC , on ETTAN SMART and above all KTA with the UNICORN software . Upstream Processing at labscale : molecular Biology , cloning in yeast bacteria , culture overexpression , activity assays radioactivity . Structural Biology of membrane proteins : crystallization , electron microscopy cryo EM and negative staining , Freeze fracture Specialties : training teaching consulting in Downstream Processing purification of biomolecules for laboratory scientists theory practicals project management , seminars organisation and presentation , writing continuous management of projects in 3 languages in parallel translation into German , English , French . Multicultural international environment . Languages : mother tongue : French , fluent in English German , basic knowledges in Russian and spanish . Lived and worked studied in France and Germany .. Technologies : CryoEM
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Bioinformatician . Developing , managing and maintaining somatic cancer Next generation sequencing NGS pipelines for single nucleotide variant SNV , insertion , deletion , copy number variant CNV and structural variation SV calling while cooperating with Great Ormond Street Hospital as part of the North Thames GLH . The sequencing mainly performed on Illumina based sequencers such as iSeq , MiSeq , NextSeq and NovaSeq . The role also involves maintaining a SQL database as well as a Perl based web server for the submission of genomics analysis by wet lab staff . Furthermore , I am also involved in leading our quality ISO 15189 insepections for the bioinformatics team . . General I am an engineer specialised in bioinformatics that graduated from Uppsala University in Sweden . A native speaker in both Swedish and English and also fluent in Spanish after my time in Universidad de Deusto in Basque Country , Spain . During my time studying , I have involved myself in various extracurricular activities , such as being a part of different boards , research projects etc . I am a motivated individual that is always interested in stepping into a new challenge in order to become better at what I do . As I have a bachelor in biotechnology and a masters in bioinformatics , I have experience from both dry and wet lab environments . I am not afraid to enter unknown fields topics as long as I am given the opportunity to develop . In my time in Uppsala University , I was a project leader of a student driven research project as well as president and member of different boards . Such activities have made me improve working in a team and helped me understand the dynamics of how to be a good team leader . Work My work has mainly focused on clinical bioinformatics where I have developed pipelines for both analysing DNA and RNA from Next Generation Sequencing data to detect single nucleotide variants , indels insertions deletions , copy number variations and structural variations . Coding experience The main programming languages I use and where I have expert experience are Python , R , Bash and MySQL while I have intermediate experience with HTML , CSS and Latex . I am also a frequent user of Linux based terminals and have limited knowledge of Windows DOS . Workflow mangers container technology I predominantly use NextFlow but I have also used Snakemake . In the case of container technologies , I have experience with both Docker and Singularity . . Technologies :
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. . I am a patient and advocate for people with myalgic encephalomyelitis ME , aka CFS , SEID . I use my scientific background and personal experience with ME to educate the medical and researcher communities about the disease . I am also a yoga teacher . I draw upon a wide range of yoga styles and traditions to help all people achieve a sense of internal and external ease and stability . As a research scientist , my work has been focused on protein structure and function . I have used X ray crystallography , cryo electron microscopy , stopped flow spectroscopy , Biacore , and other techniques to answer questions about virus structure and enzyme mechanism .. Technologies : Xray;CryoEM
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proteins;formulation;structure
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Doctoral Candidate . PhD researcher position at the Daumke Lab of the Max Delbr ck Center for molecular medicine of the Helmholtz Society . My projects focuses on structural studies of mitochondrial membrane associated complexes . Protein X ray crystallography Protein cryo EM HPLC for protein purification using an automated Agilent HPLC pipeline and KTA pure FPLC Purifier . Originally from Greece , now a PhD student at the AG Daumke of the Max Delbr ck Center in Berlin . Previously a biochemistry postgraduate student at the University of Oxford and an undergraduate DAAD scholar based in the Freie Universit t Berlin . Within biochemistry intrigued by membrane and inflammatory signaling and the use of structural biology to study them . Passionate about project management and community building within biosciences and interdisciplinarily with other sectors with the goal of expanding and diversifying the discource in life sciences . Contact : nathanailevaggelia at gmail.com . Technologies : Xray;CryoEM
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proteins;interaction;structure
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Senior Research Software Developer . . . Technologies :
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Principal Scientist . . I 'm passionate about using my background in computer science and machine learning to help improve human health and fight disease . I love working in vibrant , inter disciplinary , and highly collaborative teams . I have extensive experience developing machine learning algorithms , analyzing NGS data , and leading cross functional collaborative projects in the fields of rare disease diagnosis , epigenomics , synthetic biology , and immunotherapies . I also love sharing my passion about computer science , genomics , and STEM education through activities such as mentoring and college outreach .. Technologies :
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Bioinformatician . . Applied mathematics graduate , looking to pursue a career in medical research and development using theoretical and computational methods . Recently finished studying a biomedical engineering degree at The University of Sheffield : Computational Medicine MSc . A pioneering area of healthcare engineering , MSc Computational Medicine is teaching a new generation to become digital specialists in computer modelling for disease diagnosis , treatment and prevention . Taught by in silico medicine researchers and experts from the Insigneo Institute . https : insigneo.org msc computational medicine 2019 . Technologies :
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Principal Scientist Head of Laboratory Project Leader . . I am a biomedical research scientist with extensive experience in project design , lead and management in academia , medical research centers and industry . I have 15 years of scientific expertise in cancer biology and oncogenic signaling with 10 years of experience in preclinical target identification , validation and drug discovery . In my current position , I am a Principal Scientist leading a lab in the Molecular Targeted Therapy Department , Discovery Oncology , Roche pRED . We work on Drug Discovery and Biology of tumor cell intrinsic as well as cancer immunotherapy targets . We develop small molecules , bifunctional degraders aka PROTACs and molecular glue degraders to advance and expand therapy options for cancer patients with high unmet medical need . I am also Project Leader of multifunctional Drug Discovery Programs and have expertise in the development of advanced cellular assays for HT screening . My experience and skills include : Expertise in oncogenic signaling and mechanisms of metastasis Targeted Therapy and Translational Cancer Research Lead of Drug Discovery Project , Target Identification , Target Validation , HT Assay Development High throughput genetic and phenotypic screening approaches and their analysis 2D and 3D assay development for medium and high throughput screens Track record of successful basic , preclinical and drug discovery project management Strong strategic thinking , long term planning and goal setting skills Experienced in lead and management of cross functional and global matrix teams Enthusiastic initiative scientist with a result oriented and well organized personality Concise communicator with strong written and verbal presentation skills Interactive team player with excellent interpersonal and people management skills . Technologies :
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molecular glues;small molecules;interaction;screening
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Visiting Scientist . Apply various biophysical characterization techniques in particular Cryo EM , FTIR , Raman , DLS , Fluorescence spectroscopy , NMR , and DSC to characterize protein , Nucleic acid , Viral particle for gene therapy , and to support understanding biotherapeutic products and bioprocess development . Perform method development and comparability study for different products including mRNA vaccine , LNP , and AAV . Collaborate with multiple groups to investigate and to interrogate RNA structure at single nucleotide resolution performing RNA chemical modification , Reverse Transcription and second strand synthesis . . PhD in chemical engineering with focus on nanomaterial synthesis and characterization for better understanding their shape , size , and structure dependent properties . 2 years postdoctoral experience at Washington university in St. Louis MO . Conducted 3 projects independently and 3 projects as a member of collaborative projects . 8 years of experience in chemical engineering specializing in semiconductor material and thin films for different energy conversion applications such as for solar cells and for CO2 photo reduction . Extensive experience working on collaborative projects 10 projects and ability to work individually 6 projects . Winner of 3 Awards and scholarships . 40 publications and conference presentations . 1000 citations . Technologies : CryoEM;SLS DLS;DSC;NMR
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biologics;carriers;nucleic acids;proteins;characterization;structure
|
Computational Chemist I . . Successfully lead drug design projects with medicinal chemists , biochemists , and pharmacologists . Experience with various computational and X ray crystallography tools for hit discovery , hit to lead , and lead optimizations . Computational molecular design and drug discovery Schr dinger suite , MOE , Cresset , CCDC suite etc Protein modeling , molecular dynamics , FEP , structural bioinformatics AMBER , DESMOND , MODELLER X ray crystallography refinement of protein ligand complexes Phenix suite , Coot , CCP4 Virtual screening , QSAR , pharmacophore modeling , virtual chemical library design Hybrid Quantum Mechanics Molecular Mechanics calculations Gaussian ONIOM Cheminformatics : Chemical data management , clustering , and analysis . Data analysis , deep learning , and predictive modeling R , Python , SQL , DeepChem In silico ADME Tox predictive modeling and analysis Publications : Mahasenan , K. V. et al . ACS Chem . Biol . 2020 , DOI:10.1021 acschembio.9b00754 Mahasenan , K. V. et al . ACS Med Chem Lett 2018 , DOI:10.1021 acsmedchemlett.8b00163 Bernardo Garcia , N. ; Mahasenan , K. V. , et al . ACS Chem Biol 2018,13 3 694 Acebr n , I. ; Mahasenan , K. V. et al J Am Chem Soc 2017,DOI:10.1021 jacs.7b01626 Mahasenan , K. V. et al . ACS Med Chem Lett . 2018,11;9 7 708 , DOI:10.1021 acsmedchemlett.7b00130 Mahasenan , K. V. et al . J Am Chem Soc 2017,139 5 2102 , DOI:10.1021 jacs.6b12565 Leemans E , Mahasenan K. V , et al Bioorg Med . Chem . Lett . 2016,26 3 : 1011 5 Alinari L , Mahasenan K. V. et al Blood 2015,125 16 2530 Mahasenan , K. V. and Li , C. J. Chem . Inf . Model . , 2012 , 52 5 , pp 1345 1355 Mahasenan , K. V. et al . ACS Med . Chem . Lett . , 2011 , 2 11 : 855 860 . Equal contribution . Commun Biol . 2022 , 28;5 1 395 Comput Struct Biotechnol J. 2021,17;19,5392 ACS Omega . 2021 , 20;6 30 19983 . Acc Chem Res . 2021 , 16;54 4 917 J Med Chem . 2020 , 28;63 10 5287 Nature Communications 2019 , 5;10 1 5567 Antimicrob Agents Chemother . 2019,25;63 5 e02637 PNAS 2018,24;115 17 : 4393 Sci Rep 2018,8 1 4110 Structure 2017,25 2 295 ACS Chem Neurosci . 2016,7 11 1482 Structure 2016 24 10 1729 ACS Chem Biol 2016,11 6 1525 ACS Chem Biol 2014,9 9 2058 J Biol Chem 2014,289 13 9275 J Med Chem 2013,56 20 8139 J Biol Chem 2013,288 17 12114 J Biol Chem 2013,288 11 7430 J Nat Prod 2013,76 3 311 ACS Chem Biol . 2012,7 4 761 J Med Chem 2011,54 24 8681 J Med Chem 2010,53 3 966 J Chem Inf Model 2009,49 6 1581 Chem Biol Drug Des 2008,71 5 501 Bioorg Med Chem 2007,15 18 6071 Bioorg Med Chem Lett 2006,16 23 6013 . Technologies : Xray
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Research Scientist . . I am currently investigating the relationship between the physical properties of active pharmaceutical ingredients such as insulin and process steps . The aim is to increase the stability of these active proteins , thereby reducing storage requirements and allowing broader distribution while also potentially reducing negative side effects . I have recently investigated the kinetics of formation and structural intermediates during viral capsid protein self assembly through the use of small angle scattering time resolved , X ray and neutron TR SAXS , SANS and cryo electron microscopy cryoEM as a postdoc researcher in the Andr Lab at Lund University 's Department of Biochemistry and Structural Biology . Another previous position was as an instrument postdoc with the Bio SANS instrument team of the High Flux Isotope Reactor HFIR at Oak Ridge National Lab ORNL , where my primary scientific focus was on membrane protein systems and contrast matching detergent micelle contributions , in addition to serving as an instrument scientist and local contact to support the General User Program . With classic training as a chemist , I support an analytical and measured approach to all problems . My interests lie in biology unique and complex systems that have direct applications to our own health and understanding . This motivation drives a necessity to for a physical understanding of the basis of measurement techniques and biomolecular probes , and a knowledge of computational approaches which have greatly accelerated recent developments in these areas .. Technologies : Xray;CryoEM
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membrane proteins;proteins;stability;structure
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Bioinformatics Scientist . . . Technologies :
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Junior Specialist Lab Manager Rosenblum Lab . . Hello My name Gabriella Tenorio and I 've graduated with my Bachelor of Science in Microbiology and minored in Computing Applications from San Francisco State University . During my time as an undergraduate , I have worked in a computational biology laboratory researching fitness costs and HIV 1 infected pregnant women using the programming language R .. Technologies :
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Director , Computational Biology . Lead a computational biology team with over a dozen PhD researchers , providing translational bioinformatics supports across oncology , GI , NS and rare disease therapeutic areas . Support Takeda s clinical programs : accountable for omics clinical biomarker data QC , process , and clinical database deposit ; collaborate with translational science , biostatistics , clin pharm and other teams on supporting clinical programs exploratory analysis and translational research efforts ; utilizing AI ML approaches for drug sensitivity predictions . Work closely with Takeda s drug discovery colleagues to provide computational supports on new target identification and validation . Connect and collaborate with teams across Takeda sites and functions . Method evaluation and pipeline building for data process , analysis , and integration , including WGS WES , RNAseq , Nanostring , and other types of data . Provide computational support on collaborating partnership projects , e.g. Open Target , Moffitt M2GEN , Genomic England , CBDD , and collaborate with academic field exports . Invited talks on scientific meetings : Bio IT World , 2020 , Virtual meeting . 2nd AI ML Clinical Development Pharmacovigilance Congress , 2019 , Boston , MA Bio IT World , 2019 , Boston , MA 4th Annual Next Generation Sequencing and Clinical Diagnostics Single Cell Analysis USA Congress , 2018 , Boston , MA keynote speech Bio IT World : W11 Data Science Driving Better Informed Decisions , 2018 , Boston , MA Invited talk EBI Workshops on Predictive Modeling of Biomarker , 2017 , Cambridge , MA co organizer , host , and oral presenter Biomarker Summit 2017 , San Diego , CA 5th International Conference on Biometrics Biostatistics , 2016 , Houston , TX keynote speech and section chair Biomarkers Diagnostics world congress 2016 , Philadelphia , PA AAPS National Biotechnology Conference , 2016 , Boston , MA Biomarkers Diagnostics world congress 2015 , Philadelphia , PA NGS Pharma meeting , 2013 , Frankfurt . Lead a computational biology team with over a dozen PhD researchers , providing translational bioinformatics supports across oncology , GI , NS and rare disease therapeutic areas . Support Takeda s clinical programs : accountable for omics clinical biomarker data QC , process , and clinical database deposit ; collaborate with translational science , biostatistics , clin pharm and other teams on supporting clinical programs exploratory analysis and translational research efforts ; utilizing artificial intelligence and machine learning AI ML approaches for drug sensitivity predictions , patient stratification and disease indication selections . Work closely with Takeda s drug discovery colleagues to provide computational supports on new target identification and validation . Perform data analysis and integrate internal and public domain data , supporting drug discovery efforts from project start , target validation , portfolio entry , development candidate selection , to IND . Connect and collaborate with teams across Takeda sites and functions , including drug discovery units , therapeutic area units , exploratory biostat , translational research , early target discovery , and other teams , to support forward and reverse translational research . Develop new computational methods for patient stratification and disease indication selection . Method evaluation and pipeline building for data process , analysis , and integration , including WGS WES , RNAseq , Nanostring , and other types of data . Provide computational support on collaborating partnership projects , e.g. Open Target , Moffitt M2GEN , Genomic England , CBDD , and collaborate with academic field exports . . Technologies :
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Associate Computational Biologist . Worked on antibody docking and structure prediction for antibodies using modeling softwares Performed ChIPseq data analysis to look at TF motif enrichment and single nucleotide resolution cut profile Detected alternate splicing events which helped suggest the PBM interaction requirement for PRMT5 dependent splicing events . Processed and analyzed data for Paralog CRISPR screens for multiple collaborations to find actionable biomarkers Helped analyze data from mass spectrometry experiments conducted to identify novel E3 substrates . Born and raised in India , I have received my Bachelor of Technology in Computer science and engineering at IIIT Delhi and graduated with a Master of Science in Bioinformatics degree at Georgia Institute of Technology . I am a driven , hard working individual who is seeking to gain knowledge and experience in the bioinformatics field .. Technologies :
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NERSC Strategic Partnerships Lead . Growing the impact of computational science . . I collaborate with science teams seeking powerful scientific computing and data capabilities . Partnerships in computational science can accelerate research agendas by leveraging the scale and speed of HPC . Helping science go faster with parallel computing algorithms and architectures is interesting to me .. Technologies :
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Bioinformatics Support Scientist . . Passionate leader of both software and cross functional teams . Consistent record of on time , on quality product development . Effective communicator at all levels : Senior Management , project and technical teams , customers , and collaborators Development Management for medical devices and systems for the life sciences Embedded systems , scientific applications , and algorithm development Demonstrated resilience to changes in scope , resource availability , and technical challenges KEY ACHIEVEMENTS Led development of 454 GS FLX v2.8 next gen sequencing NGS instrument to reliably deliver 1000 base pair reads and extend commercial life of product . Developed newbler DNA sequence assembly and mapping software . Managed early adopters in academia and industry Developed prototype software for several DNA sequencing applications working with internal and external customers to define requirements and validate solution . Led development of basecalling algorithms for commercial capillary electrophoresis DNA sequencer Contact Information : rwiner44 gmail.com . Technologies :
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Computational Biologist and Bioinformatics Scientist . Work for Computational Genomics group to contribute efforts to synthesize , define , and broadly deploy genomics data and methods in support of global drug discovery and development programs at Merck . Running , wrote and updating Tumor Mutational Burden TMB pipeline from thousands of patient 's whole exome sequencing WES data . Work on Next generation DNA sequencing technologies : Help to setup automated short read sequence application pipeline . Comparison of performance , sensitivity , selectivity , features and limitation of short read sequence analysis algorithms such as Bowtie2 , Star , HiSat2 , BWA , minimap2 , samtools . Work closely with scientists in the Oncology and Immuno Oncology therapeutic area to process and analyze biological data sets from NGS sources such as DNA seq WES WGS , Chip seq ATAC seq , RNA seq . Familiar with data visualization platforms such as UCSC genome browser , QIAGEN 's OmicSoft , JBrowse , cBioprotal , partek flow , IGV , etc . Support custom data processing for all platforms . Design and write source code pipelines for small interfering RNA siRNA , Small hairpin RNA shRNA , anti sense oligo ASO and single guide RNA sgRNA . Help write SNP INDEL CNV sequence analysis pipelines from software such as GATK and custom tools . Implemented in grid engine . Whole new genome analysis for : Pichia pastoris biologics production , published 2015 , Insect Genome annotation with tools like AUGUSTUS , interproscan , etc . To contribute to Data System , which is a centralized resource for genes , proteins , networks , and pathways that integrates data from public and proprietary sources . . . Technologies :
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Head of Applications . . Throughout my academic career I focused on the reconstitution and analysis of biologically relevant protein or protein nucleic acid complexes . During my PhD , I used biochemical and biophysical approaches to shed light on bacterial transcription regulation and DNA organization . At EMBL during my Postdoc , I used protein biochemistry , single molecule light microscopy and cryo Electron Microscopy to understand how cells regulated their cytoskeleton . At CRG , my laboratory wants to understand how neurons can define their local proteome , a mechanism essential for neuronal function and long term memory formation . Specifically , we aim to discover how mRNAs are distributed to axons and dendrites , which is the prerequisite for local protein production . We first focused on the development of novel , NGS coupled , high throughput interaction screens that can detect direct protein protein interactions within libraries or between protein libraries and RNA fragment pools . We have used this technology to reveal how neuronal mRNPs are coupled to the microtubules based transport machinery . In parallel , my lab remained strongly focused on protein biochemistry . Based on interactions indicated by high throughput screening , we aim to reveal the mechanochemistry that generates neuronal mRNA distribution patterns . To this end , my lab produces the required building blocks of these transport complexes by recombinantly expressing and purifying the required mammalian multi protein complexes and RNAs . Through bioanalytics and microscopy coupled live biochemistry approaches , we are currently studying how cells can transport the right specifies and amount of mRNA to the right cellular location .. Technologies : CryoEM
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nucleic acids;proteins;interaction;screening
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