instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [fos; jun; il-2]
<Options>: A: c-fos (xenopus laevis) (fbj murine osteosarcoma viral oncogene homolog s homeolog (xenopus laevis)) (aka fbj murine osteosarcoma viral oncogene homolog s homeolog)
B: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcrip... | [J; O; K] |
<Instruct>: Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [fos; jun; il-2]
<Options>: A: fos (homo sapiens) (aka fos proto-oncogene, ap-1 transcription factor subunit)
B: interleukin enhancer binding factor 2 (homo sapiens) (aka interleukin enhancer binding factor 2)
C: fos (mus musculus) (aka fbj osteosarcoma oncogene)
D: juno (homo sapiens) (aka izumo1 receptor,... | [A; H; F] |
<Instruct>: Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [fos; jun; il-2]
<Options>: A: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcription factor subunit)
B: ilf2 (homo sapiens) (aka interleukin enhancer binding factor 2)
C: il2 (homo sapiens) (aka interleukin 2)
D: colony stimulating factor 2 (homo ... | [F; I; C] |
<Instruct>: Given the context 'EC augment c-fos promoter activity in T cells; however, deletion analysis reveals no transcription factor binding sites in the promoter uniquely responsive to EC costimulation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [c-fos]
<Options>: A: c-fos (mus musculus) (aka fbj osteosarcoma oncogene)
B: fosl1 (homo sapiens) (aka fos like 1, ap-1 transcription factor subunit)
C: fos proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka fos proto-oncogene, ap-1 transcription factor subunit)
D: fosb proto-oncogene, a... | [C] |
<Instruct>: Given the context 'CD2 mAbs completely block EC effects on all of these pathways, as well as costimulation of IL-2 secretion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd2; il-2]
<Options>: A: cd2 (gallus gallus) (aka cd2 molecule)
B: interleukin 3 (homo sapiens) (aka interleukin 3)
C: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
D: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
E: ilf2 (homo sapiens) (aka interleukin enhancer binding fac... | [G; H] |
<Instruct>: Given the context 'CD2 mAbs completely block EC effects on all of these pathways, as well as costimulation of IL-2 secretion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd2; il-2]
<Options>: A: il22 (homo sapiens) (aka interleukin 22)
B: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
C: cd22 molecule (homo sapiens) (aka cd22 molecule)
D: cd228 (homo sapiens) (aka melanotransferrin)
E: il2 (homo sapiens) (aka interleukin 2)
F: cd2 molecule (homo sapiens) (aka cd2 mo... | [F; E] |
<Instruct>: Given the context 'We conclude that EC costimulation through CD2 does not trigger a single distinct costimulatory pathway in T cells, but rather, it amplifies several pathways downstream of the TCR.', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [cd2]
<Options>: A: cd2 molecule (bos taurus) (aka cd2 molecule)
B: cd22 molecule (homo sapiens) (aka cd22 molecule)
C: cd21 (homo sapiens) (aka complement c3d receptor 2)
D: cd2 molecule (homo sapiens) (aka cd2 molecule)
E: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
F: None of t... | [D] |
<Instruct>: Given the context 'Soluble CD2 mAbs block EC-induced raft aggregation, whereas cross-linking CD2 promotes aggregation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd2]
<Options>: A: cd2 (homo sapiens) (aka cd2 molecule)
B: cd2 (gallus gallus) (aka cd2 molecule)
C: cd21 (homo sapiens) (aka complement c3d receptor 2)
D: cd22 molecule (homo sapiens) (aka cd22 molecule)
E: cd228 (homo sapiens) (aka melanotransferrin)
F: None of the above. | [A] |
<Instruct>: Given the context 'These data are consistent with the critical role of CD2 in organizing the T cell-APC contact zone.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd2]
<Options>: A: cd2 molecule (bos taurus) (aka cd2 molecule)
B: cd228 (homo sapiens) (aka melanotransferrin)
C: cd21 (homo sapiens) (aka complement c3d receptor 2)
D: cd2 molecule (homo sapiens) (aka cd2 molecule)
E: cd22 (homo sapiens) (aka cd22 molecule)
F: None of the above. | [D] |
<Instruct>: Given the context 'AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [mammalian target of rapamycin; mtor]
<Options>: A: mechanistic target of rapamycin kinase (sus scrofa) (aka mechanistic target of rapamycin kinase)
B: mtor (mus musculus) (aka mechanistic target of rapamycin kinase)
C: mtor (drosophila melanogaster) (megator (drosophila melanogaster)) (aka megator)
D: mech... | [H; H] |
<Instruct>: Given the context 'AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [mammalian target of rapamycin; mtor]
<Options>: A: mtor (drosophila melanogaster) (megator (drosophila melanogaster)) (aka megator)
B: target of rapamycin homolog (caenorhabditis elegans) (aka target of rapamycin homolog)
C: mechanistic target of rapamycin kinase (homo sapiens) (aka mechanistic target of r... | [I; I] |
<Instruct>: Given the context 'The activity of alpha1 AMPK remained unchanged in gastrocnemius muscle from AICAR-treated animals compared with controls, whereas alpha2 AMPK activity was significantly increased (51%).', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [alpha1 ampk; alpha2 ampk]
<Options>: A: ampka1 (homo sapiens) (aka protein kinase amp-activated catalytic subunit alpha 1)
B: ampk (homo sapiens) (protein kinase amp-activated catalytic subunit alpha 1 (homo sapiens)) (aka protein kinase amp-activated catalytic subunit alpha 1)
C: ampkalpha1 (mus musculus)... | [J; J] |
<Instruct>: Given the context 'The activity of alpha1 AMPK remained unchanged in gastrocnemius muscle from AICAR-treated animals compared with controls, whereas alpha2 AMPK activity was significantly increased (51%).', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [alpha1 ampk; alpha2 ampk]
<Options>: A: ampka1 (homo sapiens) (aka protein kinase amp-activated catalytic subunit alpha 1)
B: alpha kinase 1 (homo sapiens) (aka alpha kinase 1)
C: ampkalpha1 (mus musculus) (aka protein kinase, amp-activated, alpha 1 catalytic subunit)
D: protein kinase camp-activated catal... | [I; I] |
<Instruct>: Given the context 'This depression was associated with decreased activation of protein kinases in the mammalian target of rapamycin (mTOR) signal transduction pathway as evidenced by reduced phosphorylation of protein kinase B on Ser(473), mTOR on Ser(2448), ribosomal protein S6 kinase on Thr(389), and euka... | <Mentions>: [mammalian target of rapamycin; mtor; ribosomal protein s6 kinase]
<Options>: A: rps6ka6 (homo sapiens) (aka ribosomal protein s6 kinase a6)
B: mechanistic target of rapamycin kinase (sus scrofa) (aka mechanistic target of rapamycin kinase)
C: rps6ka1 (homo sapiens) (aka ribosomal protein s6 kinase a1)
D: m... | [N; N; N] |
<Instruct>: Given the context 'This depression was associated with decreased activation of protein kinases in the mammalian target of rapamycin (mTOR) signal transduction pathway as evidenced by reduced phosphorylation of protein kinase B on Ser(473), mTOR on Ser(2448), ribosomal protein S6 kinase on Thr(389), and euka... | <Mentions>: [mammalian target of rapamycin; mtor; ribosomal protein s6 kinase]
<Options>: A: s6kb (homo sapiens) (aka ribosomal protein s6 kinase b2)
B: ribosomal protein s6 kinase polypeptide 6 (mus musculus) (aka ribosomal protein s6 kinase polypeptide 6)
C: mechanistic target of rapamycin kinase (sus scrofa) (aka me... | [M; M; M] |
<Instruct>: Given the context 'This depression was associated with decreased activation of protein kinases in the mammalian target of rapamycin (mTOR) signal transduction pathway as evidenced by reduced phosphorylation of protein kinase B on Ser(473), mTOR on Ser(2448), ribosomal protein S6 kinase on Thr(389), and euka... | <Mentions>: [mammalian target of rapamycin; mtor; ribosomal protein s6 kinase]
<Options>: A: s6k (homo sapiens) (aka ribosomal protein s6 kinase b1)
B: mtor (drosophila melanogaster) (megator (drosophila melanogaster)) (aka megator)
C: target of rapamycin homolog (caenorhabditis elegans) (aka target of rapamycin homolo... | [O; O; O] |
<Instruct>: Given the context 'A reduction in eIF4E associated with eIF4G to 10% of the control value was also noted.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eif4e; eif4g]
<Options>: A: eif4g (drosophila melanogaster) (eukaryotic translation initiation factor 4g1 (drosophila melanogaster)) (aka eukaryotic translation initiation factor 4g1)
B: eif4e (xenopus laevis) (eukaryotic translation initiation factor 4e l homeolog (xenopus laevis)) (aka eukaryotic transla... | [K; K] |
<Instruct>: Given the context 'A reduction in eIF4E associated with eIF4G to 10% of the control value was also noted.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eif4e; eif4g]
<Options>: A: eif4f (homo sapiens) (eukaryotic translation initiation factor 4e (homo sapiens)) (aka eukaryotic translation initiation factor 4e)
B: eif4e (xenopus laevis) (eukaryotic translation initiation factor 4e l homeolog (xenopus laevis)) (aka eukaryotic translation initiation factor 4... | [K; K] |
<Instruct>: Given the context 'In contrast, eIF2B activity remained unchanged in response to AICAR treatment and therefore would not appear to contribute to the depression in protein synthesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [eif2b]
<Options>: A: eif-2bbeta (homo sapiens) (aka eukaryotic translation initiation factor 2b subunit beta)
B: eif2b (drosophila melanogaster) (eukaryotic translation initiation factor 2b subunit beta (drosophila melanogaster)) (aka eukaryotic translation initiation factor 2b subunit beta)
C: eif2b (homo... | [E] |
<Instruct>: Given the context 'Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [protocadherin lkc]
<Options>: A: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
B: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
C: protocadherin 1 (homo sapiens) (aka protocadherin 1)
D: pcdh7 (homo sapiens) (aka protocadherin 7)
E: protocadherin 12 (homo sapiens) (aka protocadhe... | [F] |
<Instruct>: Given the context 'The gene was predominantly expressed in liver, kidney and colon tissues, and was thus designated Protocadherin LKC.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [protocadherin lkc]
<Options>: A: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
B: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
C: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
D: pcdhac (homo sapiens) (aka protocadherin alpha constant)
E: protocadherin 10 (homo sapiens) (aka p... | [F] |
<Instruct>: Given the context 'The expression of Protocadherin LKC is markedly reduced in cancers arising from these tissues at both transcriptional and protein levels.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [protocadherin lkc]
<Options>: A: pcdh7 (homo sapiens) (aka protocadherin 7)
B: pcdhac (homo sapiens) (aka protocadherin alpha constant)
C: protocadherin 1 (homo sapiens) (aka protocadherin 1)
D: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
E: pcdhgc (homo sapiens) (aka protocadherin gamma constan... | [F] |
<Instruct>: Given the context 'To investigate the effects of Protocadherin LKC expression in colon cancer, we introduced the gene into colon cancer cell line HCT116, which does not express this gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [protocadherin lkc]
<Options>: A: protocadherin 1 (homo sapiens) (aka protocadherin 1)
B: protocadherin 10 (homo sapiens) (aka protocadherin 10)
C: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
D: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
E: pcdhg (homo sapiens) (aka protocadh... | [F] |
<Instruct>: Given the context 'Significantly, Protocadherin LKC expression induced contact inhibition of cell proliferation although it did not affect growth rate.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [protocadherin lkc]
<Options>: A: pcdhac (homo sapiens) (aka protocadherin alpha constant)
B: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
C: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
D: protocadherin 7 (homo sapiens) (aka protocadherin 7)
E: pcdh-pc (homo sapiens) (aka pro... | [F] |
<Instruct>: Given the context 'When grown to post-confluence in monolayer cells cultures, Protocadherin LKC-expressing HCT116 no longer formed multiple cell layers and showed the typical paving stone morphology of normal epithelial cells.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [protocadherin lkc]
<Options>: A: protocadherin 1 (homo sapiens) (aka protocadherin 1)
B: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
C: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
D: pcdhac (homo sapiens) (aka protocadherin alpha constant)
E: pcdh7 (homo sapiens) (aka protoca... | [F] |
<Instruct>: Given the context 'Furthermore, expression of Protocadherin LKC suppressed tumor formation of HCT116 cells in a nude mouse model.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [protocadherin lkc]
<Options>: A: pcdh7 (homo sapiens) (aka protocadherin 7)
B: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
C: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
D: protocadherin 12 (homo sapiens) (aka protocadherin 12)
E: pcdhac (homo sapiens) (aka protocadherin alph... | [F] |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept ... | <Mentions>: [hmast205; microtubule-associated serine/threonine kinase-205 kda; protocadherin lkc]
<Options>: A: mstp105 (homo sapiens) (aka early endosome antigen 1)
B: ygr205w (saccharomyces cerevisiae s288c) (aka putative atp-dependent kinase)
C: mast205 (mus musculus) (aka microtubule associated serine/threonine kin... | [M; M; O] |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept ... | <Mentions>: [hmast205; microtubule-associated serine/threonine kinase-205 kda; protocadherin lkc]
<Options>: A: mast 205 (drosophila melanogaster) (aka drop out)
B: microtubule associated serine/threonine kinase 1 (homo sapiens) (aka microtubule associated serine/threonine kinase 1)
C: pcdhgc3 (homo sapiens) (aka proto... | [F; F; O] |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept ... | <Mentions>: [hmast205; microtubule-associated serine/threonine kinase-205 kda; protocadherin lkc]
<Options>: A: mstp105 (homo sapiens) (aka early endosome antigen 1)
B: microtubule associated serine/threonine kinase 1 (homo sapiens) (aka microtubule associated serine/threonine kinase 1)
C: protocadherin 12 (homo sapien... | [I; I; O] |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept ... | <Mentions>: [protocadherin lkc]
<Options>: A: protocadherin 12 (homo sapiens) (aka protocadherin 12)
B: protocadherin 7 (homo sapiens) (aka protocadherin 7)
C: protocadherin 10 (homo sapiens) (aka protocadherin 10)
D: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
E: pcdhg (homo sapiens) (aka protocadh... | [F] |
<Instruct>: Given the context 'Our results suggest that Protocadherin LKC, which directly binds PDZ protein, is a molecular switch for contact inhibition of epithelial cells in the liver, kidney and colon tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [protocadherin lkc; pdz protein]
<Options>: A: protocadherin 7 (homo sapiens) (aka protocadherin 7)
B: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
C: pdz domain-containing protein 9-like (xenopus tropicalis) (aka pdz domain-containing protein 9-like)
D: pdz domain containing 7 (homo sapiens) (a... | [K; K] |
<Instruct>: Given the context 'Our results suggest that Protocadherin LKC, which directly binds PDZ protein, is a molecular switch for contact inhibition of epithelial cells in the liver, kidney and colon tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [protocadherin lkc; pdz protein]
<Options>: A: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
B: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
C: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
D: pdz domain containing 1 (homo sapiens) (aka pdz domain containing 1)
E: pdzd4 (homo s... | [K; K] |
<Instruct>: Given the context 'Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [daxx; histone deacetylase ii; chromatin-associated protein dek]
<Options>: A: dek (xenopus tropicalis) (aka dek proto-oncogene)
B: dek proto-oncogene (homo sapiens) (aka dek proto-oncogene)
C: histone deacetylase 9 (homo sapiens) (aka histone deacetylase 9)
D: dek (danio rerio) (aka dek proto-oncogene)
E: ... | [N; K; B] |
<Instruct>: Given the context 'Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [daxx; histone deacetylase ii; chromatin-associated protein dek]
<Options>: A: daxx (xenopus tropicalis) (aka death-associated protein 6)
B: rpd3 (homo sapiens) (histone deacetylase 2 (homo sapiens)) (aka histone deacetylase 2)
C: daxx-like protein (drosophila melanogaster) (aka daxx-like protein)
D: dek (x... | [O; B; I] |
<Instruct>: Given the context 'Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [daxx; histone deacetylase ii; chromatin-associated protein dek]
<Options>: A: daxx (xenopus tropicalis) (aka death-associated protein 6)
B: histone deacetylase 3 (homo sapiens) (aka histone deacetylase 3)
C: histone deacetylase 2 (xenopus tropicalis) (aka histone deacetylase 2)
D: daxx (xenopus laevis) (ak... | [H; N; E] |
<Instruct>: Given the context 'Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [daxx; histone deacetylase ii; chromatin-associated protein dek]
<Options>: A: dek proto-oncogene (homo sapiens) (aka dek proto-oncogene)
B: daxx (homo sapiens) (aka death domain associated protein)
C: daxx (xenopus tropicalis) (aka death-associated protein 6)
D: histone deacetylase 10 (homo sapiens) (aka h... | [B; M; A] |
<Instruct>: Given the context 'Human Daxx is a protein that functions, in part, as a transcriptional co-repressor through its interaction with a growing number of nuclear, DNA-associated proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options... | <Mentions>: [daxx]
<Options>: A: daxx (drosophila melanogaster) (aka daxx-like protein)
B: daxx (homo sapiens) (aka death domain associated protein)
C: daxx (xenopus tropicalis) (aka death-associated protein 6)
D: daxx (xenopus laevis) (aka death-associated protein 6 l homeolog)
E: daxx (mus musculus) (aka fas death do... | [B] |
<Instruct>: Given the context 'To determine the mechanism by which hDaxx represses transcription, we used conventional chromatography to isolate endogenous hDaxx.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [hdaxx]
<Options>: A: daxx (homo sapiens) (aka death domain associated protein)
B: ndaxoa (homo sapiens) (aka succinate dehydrogenase complex flavoprotein subunit a)
C: axed on x (drosophila melanogaster) (aka axed on x)
D: daxx (danio rerio) (aka death-domain associated protein)
E: hyrax (drosophila melano... | [A] |
<Instruct>: Given the context 'We determined that hDaxx has an apparent molecular weight of 360 kDa, which is consistent with the fact that multiple domains of hDaxx are required for transcriptional repression and suggests that hDaxx associates with multiple proteins.', select the correct biomedical concept for each me... | <Mentions>: [hdaxx]
<Options>: A: daxx (homo sapiens) (aka death domain associated protein)
B: ndaxoa (homo sapiens) (aka succinate dehydrogenase complex flavoprotein subunit a)
C: daxx (drosophila melanogaster) (aka daxx-like protein)
D: daxx (xenopus tropicalis) (aka death-associated protein 6)
E: adx (homo sapiens) ... | [A] |
<Instruct>: Given the context 'Using co-fractionation and co-immunoprecipitation we demonstrate that hDaxx associates with proteins that are critical for transcriptional repression, such as histone deacetylase II, constituents of chromatin such as core histones H2A, H2B, H3 and H4, and Dek, a chromatin-associated prote... | <Mentions>: [hdaxx; histone deacetylase ii]
<Options>: A: histone deacetylase 10 (homo sapiens) (aka histone deacetylase 10)
B: daxx (homo sapiens) (aka death domain associated protein)
C: histone deacetylase 1 (homo sapiens) (aka histone deacetylase 1)
D: daxx (xenopus laevis) (aka death-associated protein 6 l homeolo... | [B; F] |
<Instruct>: Given the context 'Using co-fractionation and co-immunoprecipitation we demonstrate that hDaxx associates with proteins that are critical for transcriptional repression, such as histone deacetylase II, constituents of chromatin such as core histones H2A, H2B, H3 and H4, and Dek, a chromatin-associated prote... | <Mentions>: [hdaxx; histone deacetylase ii]
<Options>: A: daxx (drosophila melanogaster) (aka daxx-like protein)
B: histone deacetylase 10 (homo sapiens) (aka histone deacetylase 10)
C: axed on x (drosophila melanogaster) (aka axed on x)
D: hdac2 (homo sapiens) (aka histone deacetylase 2)
E: daxx (homo sapiens) (aka de... | [E; D] |
<Instruct>: Given the context 'We also demonstrate a requirement for the SPT domain and the first paired amphipathic helix of hDaxx for its association with histone deacetylase II and acetylated histone H4, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [hdaxx; histone deacetylase ii]
<Options>: A: histone deacetylase 10 (homo sapiens) (aka histone deacetylase 10)
B: daxx (drosophila melanogaster) (aka daxx-like protein)
C: histone deacetylase 2 (xenopus tropicalis) (aka histone deacetylase 2)
D: histone deacetylase 1 (homo sapiens) (aka histone deacetylas... | [J; F] |
<Instruct>: Given the context 'We also demonstrate a requirement for the SPT domain and the first paired amphipathic helix of hDaxx for its association with histone deacetylase II and acetylated histone H4, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [hdaxx; histone deacetylase ii]
<Options>: A: ndaxoa (homo sapiens) (aka succinate dehydrogenase complex flavoprotein subunit a)
B: daxx (xenopus laevis) (aka death-associated protein 6 l homeolog)
C: histone deacetylase 1 (homo sapiens) (aka histone deacetylase 1)
D: histone deacetylase 2 (mus musculus) (a... | [F; H] |
<Instruct>: Given the context 'Finally, we provide evidence suggesting that the association of hDaxx with chromatin-related proteins is dependent on the post-translational phosphorylation status of hDaxx.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [hdaxx]
<Options>: A: axed on x (drosophila melanogaster) (aka axed on x)
B: daxx (xenopus tropicalis) (aka death-associated protein 6)
C: adx (homo sapiens) (aka ferredoxin 1)
D: hyrax (drosophila melanogaster) (aka hyrax)
E: daxx (homo sapiens) (aka death domain associated protein)
F: None of the above. | [E] |
<Instruct>: Given the context 'A working model for the repressive action of hDaxx through its association with chromatin related proteins is presented.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [hdaxx]
<Options>: A: axed on x (drosophila melanogaster) (aka axed on x)
B: adx (homo sapiens) (aka ferredoxin 1)
C: daxx (drosophila melanogaster) (aka daxx-like protein)
D: daxx (homo sapiens) (aka death domain associated protein)
E: ndaxoa (homo sapiens) (aka succinate dehydrogenase complex flavoprotein... | [D] |
<Instruct>: Given the context 'Regulation of human separase by securin binding and autocleavage.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase; securin]
<Options>: A: separase (candida albicans sc5314) (aka separase)
B: securin (caenorhabditis elegans) (aka securin)
C: securin (saccharomyces cerevisiae s288c) (aka securin)
D: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid s... | [G; D] |
<Instruct>: Given the context 'Regulation of human separase by securin binding and autocleavage.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase; securin]
<Options>: A: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
B: securin (saccharomyces cerevisiae s288c) (aka securin)
C: separase (drosophila melanogaster) (aka separase)
D: extra spindle pole bodies like 1, separase (xenopus tropicalis)... | [G; F] |
<Instruct>: Given the context 'BACKGROUND: Sister chromatid separation is initiated by separase, a protease that cleaves cohesin and thereby dissolves sister chromatid cohesion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [separase]
<Options>: A: separase (candida albicans sc5314) (aka separase)
B: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
C: separase (drosophila melanogaster) (aka separase)
D: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens... | [D] |
<Instruct>: Given the context 'Separase is activated by the degradation of its inhibitor securin and by the removal of inhibitory phosphates.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase; securin]
<Options>: A: separase (drosophila melanogaster) (aka separase)
B: separin homolog sep-1 (caenorhabditis elegans) (aka separin homolog sep-1)
C: securin (caenorhabditis elegans) (aka securin)
D: securin (oryctolagus cuniculus) (aka securin)
E: pttg1 regulator of sister chromatid separati... | [H; E] |
<Instruct>: Given the context 'Separase is activated by the degradation of its inhibitor securin and by the removal of inhibitory phosphates.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase; securin]
<Options>: A: separase (saccharomyces cerevisiae s288c) (aka separase)
B: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
C: pttg1 regulator of sister chromatid separation, securin (danio rerio) (aka ptt... | [J; B] |
<Instruct>: Given the context 'In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated.', select the correct biomedical concept for each mention using the provided o... | <Mentions>: [separase]
<Options>: A: separase (saccharomyces cerevisiae s288c) (aka separase)
B: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
C: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, sepa... | [C] |
<Instruct>: Given the context 'In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated.', select the correct biomedical concept for each mention using the provided o... | <Mentions>: [separase]
<Options>: A: separase (saccharomyces cerevisiae s288c) (aka separase)
B: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
C: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, sepa... | [C] |
<Instruct>: Given the context 'In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated.', select the correct biomedical concept for each mention using the provided o... | <Mentions>: [separase]
<Options>: A: separase (saccharomyces cerevisiae s288c) (aka separase)
B: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
C: separase (drosophila melanogaster) (aka separase)
D: extra spindle pole bodies 1, separase (mus musculus) (aka extr... | [E] |
<Instruct>: Given the context 'Inhibition of separase expression in human cells by RNA interference causes the formation of polyploid cells with large lobed nuclei.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [separase]
<Options>: A: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
B: separase (saccharomyces cerevisiae s288c) (aka separase)
C: separin homolog sep-1 (caenorhabditis elegans) (aka separin homolog sep-1)
D: separase (drosophila melanogaster) ... | [A] |
<Instruct>: Given the context 'Inhibitor binding experiments in vitro reveal that securin prevents the access of substrate analogs to the active site of separase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [securin; separase]
<Options>: A: securin-like protein (caenorhabditis elegans) (aka securin-like protein)
B: securin (oryctolagus cuniculus) (aka securin)
C: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
D: securin (saccharomyces cerevisiae s288c) (aka sec... | [E; F] |
<Instruct>: Given the context 'Inhibitor binding experiments in vitro reveal that securin prevents the access of substrate analogs to the active site of separase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [securin; separase]
<Options>: A: separin homolog sep-1 (caenorhabditis elegans) (aka separin homolog sep-1)
B: securin-like protein (caenorhabditis elegans) (aka securin-like protein)
C: securin (oryctolagus cuniculus) (aka securin)
D: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra sp... | [F; D] |
<Instruct>: Given the context 'Upon securin degradation, the active site of full-length separase becomes accessible, allowing rapid autocatalytic cleavage of separase at one of three sites.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [securin; separase]
<Options>: A: separase (drosophila melanogaster) (aka separase)
B: securin (caenorhabditis elegans) (aka securin)
C: pttg1 regulator of sister chromatid separation, securin (danio rerio) (aka pttg1 regulator of sister chromatid separation, securin)
D: pttg1 regulator of sister chromatid ... | [D; G] |
<Instruct>: Given the context 'Upon securin degradation, the active site of full-length separase becomes accessible, allowing rapid autocatalytic cleavage of separase at one of three sites.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [securin; separase]
<Options>: A: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
B: separase (candida albicans sc5314) (aka separase)
C: pttg1 regulator of sister chromatid separation, securin (danio rerio) (aka pttg1 regulator of sister chromatid ... | [J; A] |
<Instruct>: Given the context 'The resulting N- and C-terminal fragments remain associated and can be reinhibited by securin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [securin]
<Options>: A: securin (caenorhabditis elegans) (aka securin)
B: pttg1 regulator of sister chromatid separation, securin (bos taurus) (aka pttg1 regulator of sister chromatid separation, securin)
C: securin-like protein (caenorhabditis elegans) (aka securin-like protein)
D: pttg1 regulator of siste... | [D] |
<Instruct>: Given the context 'The resulting N- and C-terminal fragments remain associated and can be reinhibited by securin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [securin]
<Options>: A: pttg1 regulator of sister chromatid separation, securin (danio rerio) (aka pttg1 regulator of sister chromatid separation, securin)
B: pttg1 regulator of sister chromatid separation, securin (bos taurus) (aka pttg1 regulator of sister chromatid separation, securin)
C: securin (caenor... | [E] |
<Instruct>: Given the context 'A noncleavable separase mutant retains its ability to cleave cohesin in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase]
<Options>: A: homolog of separase (arabidopsis thaliana) (aka separase)
B: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
C: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
D... | [D] |
<Instruct>: Given the context 'Our results suggest that separase is required for sister chromatid separation during mitosis in human cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase]
<Options>: A: separase (drosophila melanogaster) (aka separase)
B: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
C: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
D: separa... | [E] |
<Instruct>: Given the context 'Our data further indicate that securin inhibits separase by blocking the access of substrates to the active site of separase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [securin; separase]
<Options>: A: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
B: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
C: securin (saccharomyces cerevis... | [B; D] |
<Instruct>: Given the context 'Our data further indicate that securin inhibits separase by blocking the access of substrates to the active site of separase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [securin; separase]
<Options>: A: provisional ortholog of pttg1 regulator of sister chromatid separation, securin (xenopus tropicalis) (aka provisional ortholog of pttg1 regulator of sister chromatid separation, securin)
B: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodi... | [G; D] |
<Instruct>: Given the context 'Securin proteolysis allows autocatalytic processing of separase into a cleaved form, but separase cleavage is not essential for separase activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each me... | <Mentions>: [securin; separase]
<Options>: A: securin (xenopus laevis) (aka securin)
B: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
C: separase (drosophila melanogaster) (aka separase)
D: separase (candida albicans sc5314) (aka separase)
E: securin (caenorh... | [F; B] |
<Instruct>: Given the context 'Securin proteolysis allows autocatalytic processing of separase into a cleaved form, but separase cleavage is not essential for separase activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each me... | <Mentions>: [securin; separase]
<Options>: A: sec62 homolog, preprotein translocation factor s homeolog (xenopus laevis) (aka sec62 homolog, preprotein translocation factor s homeolog)
B: separase (saccharomyces cerevisiae s288c) (aka separase)
C: pttg1 regulator of sister chromatid separation, securin (bos taurus) (ak... | [G; I] |
<Instruct>: Given the context 'Securin proteolysis allows autocatalytic processing of separase into a cleaved form, but separase cleavage is not essential for separase activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each me... | <Mentions>: [securin; separase]
<Options>: A: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
B: homolog of separase (arabidopsis thaliana) (aka separase)
C: sec62 homolog, preprotein translocation factor s homeolog (xenopus laevis) (aka sec62 homolog, preprotein... | [J; F] |
<Instruct>: Given the context 'Contribution of CD3 gamma to TCR regulation and signaling in human mature T lymphocytes.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd3 gamma]
<Options>: A: cd3 gamma subunit of t-cell receptor complex (bos taurus) (aka cd3 gamma subunit of t-cell receptor complex)
B: cd3 gamma subunit of t-cell receptor complex (rattus norvegicus) (aka cd3 gamma subunit of t-cell receptor complex)
C: cd3 gamma subunit of t-cell receptor complex (homo ... | [C] |
<Instruct>: Given the context 'We report here on the participation of CD3 gamma in the activation and effector function of human mature T lymphocytes at the antigen recognition checkpoint.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one fo... | <Mentions>: [cd3 gamma]
<Options>: A: interleukin 2 receptor subunit gamma (homo sapiens) (aka interleukin 2 receptor subunit gamma)
B: cd3 gamma subunit of t-cell receptor complex (rattus norvegicus) (aka cd3 gamma subunit of t-cell receptor complex)
C: cd3g (homo sapiens) (tcr gamma alternate reading frame protein (h... | [D] |
<Instruct>: Given the context 'Following TCR-CD3 engagement of human CD3 gamma-deficient T cell lines, and despite their lower TCR-CD3 surface levels compared to normal controls, mature T cell responses such as protein tyrosine phosphorylation and the regulation of expression of several cell surface molecules, includin... | <Mentions>: [cd3 gamma]
<Options>: A: cd3 gamma subunit of t-cell receptor complex (sus scrofa) (aka cd3 gamma subunit of t-cell receptor complex)
B: cd3 gamma subunit of t-cell receptor complex (rattus norvegicus) (aka cd3 gamma subunit of t-cell receptor complex)
C: cd3g (homo sapiens) (tcr gamma alternate reading fr... | [E] |
<Instruct>: Given the context 'In contrast, other physiological responses like the specific adhesion and concomitant cell polarization on ICAM-1-coated dishes were selectively defective, and activation-induced cell death was increased.', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [icam-1]
<Options>: A: intercellular adhesion molecule 5 (homo sapiens) (aka intercellular adhesion molecule 5)
B: intercellular adhesion molecule 1 (homo sapiens) (aka intercellular adhesion molecule 1)
C: icam4 (homo sapiens) (aka intercellular adhesion molecule 4 (landsteiner-wiener blood group))
D: icam... | [B] |
<Instruct>: Given the context 'Our data indicate that CD3 gamma contributes essential specialized signaling functions to certain mature T cell responses.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [cd3 gamma]
<Options>: A: cd3-gammaamma (homo sapiens) (aka cd3 gamma subunit of t-cell receptor complex)
B: cd3epsilon (homo sapiens) (aka cd3 epsilon subunit of t-cell receptor complex)
C: cd3 gamma subunit of t-cell receptor complex (bos taurus) (aka cd3 gamma subunit of t-cell receptor complex)
D: cd3g ... | [A] |
<Instruct>: Given the context 'ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adam10; l1 adhesion molecule]
<Options>: A: l1cam (homo sapiens) (aka l1 cell adhesion molecule)
B: adam15 (homo sapiens) (aka adam metallopeptidase domain 15)
C: cell adhesion molecule l1 like (homo sapiens) (aka cell adhesion molecule l1 like)
D: metalloproteinase adam10-like (xenopus tropicalis) (aka me... | [H; A] |
<Instruct>: Given the context 'ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adam10; l1 adhesion molecule]
<Options>: A: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
B: adam-ts10 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 10)
C: cell adhesion molecule l1 like (homo sapiens) (aka cell adhesion molecule l1 like)
D: ada... | [F; J] |
<Instruct>: Given the context 'L1, an important molecule for cell migration of neural and tumor cells, is released by membrane-proximal cleavage, and soluble L1 promotes cell migration.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for e... | <Mentions>: [l1]
<Options>: A: cyclin l1 (homo sapiens) (aka cyclin l1)
B: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
C: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
D: l1.1 (mus musculus) (aka skull morphology 1)
E: adhesion g protein-coupled receptor l1 ... | [C] |
<Instruct>: Given the context 'L1, an important molecule for cell migration of neural and tumor cells, is released by membrane-proximal cleavage, and soluble L1 promotes cell migration.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for e... | <Mentions>: [l1]
<Options>: A: l1.1 (mus musculus) (aka skull morphology 1)
B: cyclin l1 (homo sapiens) (aka cyclin l1)
C: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
D: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
E: None of the a... | [E] |
<Instruct>: Given the context 'Release of L1 is enhanced by shedding inducers such as phorbol ester and pervanadate, but it is also enhanced by depletion of cellular cholesterol with methyl-beta-cyclodextrin (MCD).', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [l1]
<Options>: A: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
B: cyclin l1 (homo sapiens) (aka cyclin l1)
C: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
D: lethal (1) l1 (drosophila melanogaster) (aka lethal (1) l1)
E: l1.1... | [A] |
<Instruct>: Given the context 'We show here that ADAM10 is involved in L1 cleavage, which occurs at the cell surface and in the Golgi apparatus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adam10; l1]
<Options>: A: metalloproteinase adam10-like (xenopus tropicalis) (aka metalloproteinase adam10-like)
B: adam metallopeptidase with thrombospondin type 1 motif 10 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 10)
C: disintegrin and metalloproteinase domain-containing... | [H; E] |
<Instruct>: Given the context 'We show here that ADAM10 is involved in L1 cleavage, which occurs at the cell surface and in the Golgi apparatus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adam10; l1]
<Options>: A: adam-ts10 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 10)
B: adam9 (homo sapiens) (aka adam metallopeptidase domain 9)
C: adam15 (homo sapiens) (aka adam metallopeptidase domain 15)
D: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhes... | [E; H] |
<Instruct>: Given the context 'MCD and pervanadate treatment induced the release of microvesicles containing full-length L1 and the active form of ADAM10.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [l1; adam10]
<Options>: A: metalloproteinase adam10-like (xenopus tropicalis) (aka metalloproteinase adam10-like)
B: adam metallopeptidase with thrombospondin type 1 motif 10 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 10)
C: lethal (1) l1 (drosophila melanogaster) (aka lethal... | [H; I] |
<Instruct>: Given the context 'MCD and pervanadate treatment induced the release of microvesicles containing full-length L1 and the active form of ADAM10.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [l1; adam10]
<Options>: A: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
B: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
C: ad10 (homo sapiens) (adam metallopeptidase domain 10 (homo sapiens)) (aka adam metallopeptidase domain 10)
D: adhes... | [B; C] |
<Instruct>: Given the context 'L1 cleavage occurred in isolated vesicles.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [l1]
<Options>: A: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
B: cyclin l1 (homo sapiens) (aka cyclin l1)
C: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion molecule l1-like)
D: l1 cell adhesion molecule (xenopus tropicalis) (aka... | [E] |
<Instruct>: Given the context 'L1 cleavage occurred in isolated vesicles.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [l1]
<Options>: A: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion molecule l1-like)
B: cyclin l1 (homo sapiens) (aka cyclin l1)
C: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
D: l1 cell adhesion molecule (xenopus tropicalis) (aka... | [E] |
<Instruct>: Given the context 'L1-containing microvesicles could trigger haptotactic cell migration.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [l1]
<Options>: A: l(1)l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster)) (aka lethal (1) l1)
B: cyclin l1 (homo sapiens) (aka cyclin l1)
C: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
D: l1 cell adhesion molecule (homo sapiens) (aka... | [D] |
<Instruct>: Given the context 'Only the neural L1 form carrying the RSLE signal for clathrin-dependent endocytosis was recruited and cleaved in vesicles.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [l1]
<Options>: A: l1.1 (mus musculus) (aka skull morphology 1)
B: lethal (1) l1 (drosophila melanogaster) (aka lethal (1) l1)
C: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
D: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
E: ... | [C] |
<Instruct>: Given the context 'Phorbol ester treatment activated L1 cleavage predominantly at the cell surface.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [l1]
<Options>: A: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
B: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
C: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion molecule l1-like)
D: adhesion g protein-coupled receptor l1 ... | [A] |
<Instruct>: Given the context 'Our results provide evidence for two pathways of L1 cleavage, based on ADAM10 localization, that can be activated differentially: 1) direct cleavage at the cell surface, and 2) release and cleavage in secretory vesicles most likely derived from the Golgi apparatus.', select the correct bi... | <Mentions>: [l1; adam10]
<Options>: A: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homolog)
B: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
C: adam30 (homo sapiens) (aka ad... | [B; I] |
<Instruct>: Given the context 'Our results provide evidence for two pathways of L1 cleavage, based on ADAM10 localization, that can be activated differentially: 1) direct cleavage at the cell surface, and 2) release and cleavage in secretory vesicles most likely derived from the Golgi apparatus.', select the correct bi... | <Mentions>: [l1; adam10]
<Options>: A: metalloproteinase adam10-like (xenopus tropicalis) (aka metalloproteinase adam10-like)
B: adam30 (homo sapiens) (aka adam metallopeptidase domain 30)
C: cyclin l1 (homo sapiens) (aka cyclin l1)
D: adam9 (homo sapiens) (aka adam metallopeptidase domain 9)
E: l1 (drosophila melanoga... | [G; J] |
<Instruct>: Given the context 'The findings establish a novel role for ADAM10 as a vesicle-based protease.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adam10]
<Options>: A: adam9 (homo sapiens) (aka adam metallopeptidase domain 9)
B: adam15 (homo sapiens) (aka adam metallopeptidase domain 15)
C: ad10 (homo sapiens) (adam metallopeptidase domain 10 (homo sapiens)) (aka adam metallopeptidase domain 10)
D: metalloproteinase adam10-like (xenopus tropicalis) ... | [C] |
<Instruct>: Given the context 'Yaf2 inhibits Myc biological function.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [yaf2; myc]
<Options>: A: v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene homolog)
B: yaf5 (saccharomyces cerevisiae s288c) (aka ubiquitin-protein transferase activating protein pex22)
C: myc proto-oncogene, bhlh transcription factor (homo... | [D; C] |
<Instruct>: Given the context 'Yaf2 inhibits Myc biological function.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [yaf2; myc]
<Options>: A: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
B: yaf1 (saccharomyces cerevisiae s288c) (aka oleate-activated transcription factor oaf1)
C: v-myc avian myeloc... | [J; D] |
<Instruct>: Given the context 'Yaf2 inhibits Myc biological function.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [yaf2; myc]
<Options>: A: yaf2 (sus scrofa) (aka yy1 associated factor 2)
B: myc-like oncogene, s-myc protein (mus musculus) (aka myc-like oncogene, s-myc protein)
C: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related onc... | [F; D] |
<Instruct>: Given the context 'The proto-oncogenes of the myelocytomatosis viral oncogene homolog (MYC) family, including MYC, MYCN and MYCL, encode nuclear proteins that act as transcription factors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [myc; mycn; mycl]
<Options>: A: mycl (homo sapiens) (aka mycl proto-oncogene, bhlh transcription factor)
B: myc proto-oncogene, bhlh transcription factor (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
C: mycl (mus musculus) (aka v-myc avian myelocytomatosis viral oncogene lung carcinoma ... | [M; I; A] |
<Instruct>: Given the context 'The proto-oncogenes of the myelocytomatosis viral oncogene homolog (MYC) family, including MYC, MYCN and MYCL, encode nuclear proteins that act as transcription factors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [myc; mycn; mycl]
<Options>: A: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
B: mycl2 (homo sapiens) (aka mycl pseudogene 1)
C: myc (mus musculus) (myelocytomatosis oncogene (mus mus... | [I; E; L] |
<Instruct>: Given the context 'The proto-oncogenes of the myelocytomatosis viral oncogene homolog (MYC) family, including MYC, MYCN and MYCL, encode nuclear proteins that act as transcription factors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [myc; mycn; mycl]
<Options>: A: mycn proto-oncogene, bhlh transcription factor (danio rerio) (aka mycn proto-oncogene, bhlh transcription factor)
B: mycn proto-oncogene, bhlh transcription factor (xenopus tropicalis) (aka mycn proto-oncogene, bhlh transcription factor)
C: mycs-like (mus musculus) (aka cdna ... | [E; J; K] |
<Instruct>: Given the context 'The Myc protein is the best studied member of this family and is involved in cell cycle regulation, differentiation and cell death.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [myc]
<Options>: A: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
B: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
C: myc (homo sapiens... | [C] |
<Instruct>: Given the context 'We have previously demonstrated that the zinc-finger protein Yaf2 interacts with the central region of MycN and enhances MycN dependent transcriptional activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [yaf2; mycn]
<Options>: A: yaf2 (homo sapiens) (aka yy1 associated factor 2)
B: yaf1 (saccharomyces cerevisiae s288c) (aka oleate-activated transcription factor oaf1)
C: mycn (homo sapiens) (aka mycn proto-oncogene, bhlh transcription factor)
D: yaf2 (sus scrofa) (aka yy1 associated factor 2)
E: yaf2 (bos t... | [A; C] |
<Instruct>: Given the context 'We have previously demonstrated that the zinc-finger protein Yaf2 interacts with the central region of MycN and enhances MycN dependent transcriptional activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [yaf2; mycn]
<Options>: A: yaf2 (homo sapiens) (aka yy1 associated factor 2)
B: yaf2 (sus scrofa) (aka yy1 associated factor 2)
C: mycn proto-oncogene, bhlh transcription factor (danio rerio) (aka mycn proto-oncogene, bhlh transcription factor)
D: v-myc avian myelocytomatosis viral oncogene neuroblastoma de... | [A; G] |
<Instruct>: Given the context 'Here we show that Yaf2 also binds to the Myc protein in vivo and in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [yaf2; myc]
<Options>: A: myc proto-oncogene, bhlh transcription factor (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
B: yaf5 (saccharomyces cerevisiae s288c) (aka ubiquitin-protein transferase activating protein pex22)
C: v-myc avian myelocytomatosis viral oncogene homolog (gallus gall... | [D; A] |
<Instruct>: Given the context 'Here we show that Yaf2 also binds to the Myc protein in vivo and in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [yaf2; myc]
<Options>: A: c-myc-binding protein homolog (glycine max) (aka c-myc-binding protein homolog)
B: yaf2-b (xenopus laevis) (yy1 associated factor 2 s homeolog (xenopus laevis)) (aka yy1 associated factor 2 s homeolog)
C: myc-like oncogene, s-myc protein (mus musculus) (aka myc-like oncogene, s-myc... | [G; J] |
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