instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Herein we report the cDNA cloning of a human brain 25 kDa lysophospholipid-specific lysophospholipase (hLysoPLA).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lysophospholipid-specific lysophospholipase; hlysopla]
<Options>: A: patatin like domain 6, lysophospholipase (homo sapiens) (aka patatin like domain 6, lysophospholipase)
B: lysophospholipase 2 l homeolog (xenopus laevis) (aka lysophospholipase 2 l homeolog)
C: lysophospholipase 2 (homo sapiens) (aka lysophospholipase 2)
D: plosl (homo sapiens) (aka transmembrane immune signaling adaptor tyrobp)
E: ospl (homo sapiens) (aka claudin 10)
F: potocki-lupski syndrome (homo sapiens) (aka potocki-lupski syndrome)
G: lysophospholipase like 1 (homo sapiens) (aka lysophospholipase like 1)
H: lysophospholipase 1 (homo sapiens) (aka lysophospholipase 1)
I: lpsa (homo sapiens) (aka oncogene liposarcoma (dna segment, single copy, expressed, probes)
J: None of the above. | [H; H] |
<Instruct>: Given the context 'Herein we report the cDNA cloning of a human brain 25 kDa lysophospholipid-specific lysophospholipase (hLysoPLA).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lysophospholipid-specific lysophospholipase; hlysopla]
<Options>: A: lysophospholipase-like 1 (xenopus tropicalis) (aka lysophospholipase-like 1)
B: ospl (homo sapiens) (aka claudin 10)
C: hpo (homo sapiens) (aka growth factor, augmenter of liver regeneration)
D: lysophospholipase 2 l homeolog (xenopus laevis) (aka lysophospholipase 2 l homeolog)
E: lysophospholipase 1 (homo sapiens) (aka lysophospholipase 1)
F: patatin like domain 6, lysophospholipase (homo sapiens) (aka patatin like domain 6, lysophospholipase)
G: plosl (homo sapiens) (aka transmembrane immune signaling adaptor tyrobp)
H: lysophospholipase 2 (xenopus tropicalis) (aka lysophospholipase 2)
I: splash (homo sapiens) (aka phospholipase a2 group iid)
J: None of the above. | [E; E] |
<Instruct>: Given the context 'The hLysoPLA hydrolyzes lysophosphatidylcholine in both monomeric and micellar forms, and exhibits apparent cooperativity and surface dilution kinetics, but not interfacial activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hlysopla]
<Options>: A: lysophospholipase 1 (homo sapiens) (aka lysophospholipase 1)
B: spo (homo sapiens) (lactoperoxidase (homo sapiens)) (aka lactoperoxidase)
C: hpo (homo sapiens) (aka growth factor, augmenter of liver regeneration)
D: spgyla (homo sapiens) (aka deleted in azoospermia like)
E: ospl (homo sapiens) (aka claudin 10)
F: None of the above. | [A] |
<Instruct>: Given the context 'Detailed kinetic analysis indicates that the hLysoPLA binds first to the micellar surface and then to the substrate presented on the surface.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hlysopla]
<Options>: A: spgyla (homo sapiens) (aka deleted in azoospermia like)
B: hpo (homo sapiens) (aka growth factor, augmenter of liver regeneration)
C: splash (homo sapiens) (aka phospholipase a2 group iid)
D: spo (homo sapiens) (lactoperoxidase (homo sapiens)) (aka lactoperoxidase)
E: lysophospholipase 1 (homo sapiens) (aka lysophospholipase 1)
F: None of the above. | [E] |
<Instruct>: Given the context 'The kinetic parameters associated with this surface dilution kinetic model are reported, and it is concluded that hLysoPLA has a single substrate binding site and a surface recognition site.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hlysopla]
<Options>: A: plosl (homo sapiens) (aka transmembrane immune signaling adaptor tyrobp)
B: lysophospholipase 1 (homo sapiens) (aka lysophospholipase 1)
C: hpo (homo sapiens) (aka growth factor, augmenter of liver regeneration)
D: potocki-lupski syndrome (homo sapiens) (aka potocki-lupski syndrome)
E: ospl (homo sapiens) (aka claudin 10)
F: None of the above. | [B] |
<Instruct>: Given the context 'In contrast to many non-specific lipolytic enzymes that exhibit lysophospholipase activity, hLysoPLA hydrolyzes only lysophospholipids and has no other significant enzymatic activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hlysopla]
<Options>: A: spgyla (homo sapiens) (aka deleted in azoospermia like)
B: lysopld (homo sapiens) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2)
C: lysophospholipase 1 (homo sapiens) (aka lysophospholipase 1)
D: lpsa (homo sapiens) (aka oncogene liposarcoma (dna segment, single copy, expressed, probes)
E: ospl (homo sapiens) (aka claudin 10)
F: None of the above. | [C] |
<Instruct>: Given the context 'Of special interest, hLysoPLA does not act on plasmenylcholine.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hlysopla]
<Options>: A: potocki-lupski syndrome (homo sapiens) (aka potocki-lupski syndrome)
B: spgyla (homo sapiens) (aka deleted in azoospermia like)
C: lysophospholipase 1 (homo sapiens) (aka lysophospholipase 1)
D: splash (homo sapiens) (aka phospholipase a2 group iid)
E: spo (homo sapiens) (lactoperoxidase (homo sapiens)) (aka lactoperoxidase)
F: None of the above. | [C] |
<Instruct>: Given the context 'Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syt; brm]
<Options>: A: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
B: syt1 (homo sapiens) (aka synaptotagmin 1)
C: synaptotagmin-1 (xenopus tropicalis) (aka synaptotagmin-1)
D: brp (mus musculus) (aka growth differentiation factor 5)
E: syt7 (homo sapiens) (aka synaptotagmin 7)
F: brm (homo sapiens) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
G: br (mus musculus) (aka brachyrrhine)
H: mbr (homo sapiens) (aka translocator protein)
I: syt1 (xenopus tropicalis) (aka synaptotagmin 1)
J: brms1 like transcriptional repressor (bos taurus) (aka brms1 like transcriptional repressor)
K: None of the above. | [K; F] |
<Instruct>: Given the context 'Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syt; brm]
<Options>: A: brms1 like transcriptional repressor (bos taurus) (aka brms1 like transcriptional repressor)
B: brm1 (mus musculus) (aka brachyury modifier 1)
C: syt1 (xenopus tropicalis) (aka synaptotagmin 1)
D: synaptoporin (xenopus tropicalis) (aka synaptoporin)
E: brm (drosophila melanogaster) (aka brahma)
F: syt1 (homo sapiens) (aka synaptotagmin 1)
G: syt7 (homo sapiens) (aka synaptotagmin 7)
H: syt (xenopus laevis) (synaptotagmin 1 s homeolog (xenopus laevis)) (aka synaptotagmin 1 s homeolog)
I: brm (homo sapiens) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
J: br (mus musculus) (aka brachyrrhine)
K: None of the above. | [K; I] |
<Instruct>: Given the context 'The t(X;18)(p11.2;q11.2) chromosomal translocation commonly found in synovial sarcomas fuses the SYT gene on chromosome 18 to either of two similar genes, SSX1 or SSX2, on the X chromosome.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syt; ssx1; ssx2]
<Options>: A: ssx1 (homo sapiens) (aka ssx family member 1)
B: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
C: ssx2 (homo sapiens) (aka ssx family member 2)
D: structure-specific endonuclease subunit slx1 homolog (caenorhabditis elegans) (aka structure-specific endonuclease subunit slx1 homolog)
E: srpx1 (xenopus laevis) (sushi repeat containing protein x-linked s homeolog (xenopus laevis)) (aka sushi repeat containing protein x-linked s homeolog)
F: protein ssuh2 homolog (xenopus laevis) (aka protein ssuh2 homolog)
G: ssxp2 (homo sapiens) (aka ssx family member 6, pseudogene)
H: slx1 homolog a, structure-specific endonuclease subunit (xenopus tropicalis) (aka slx1 homolog a, structure-specific endonuclease subunit)
I: ssx5 (homo sapiens) (aka ssx family member 5)
J: syt-vii (homo sapiens) (aka synaptotagmin 7)
K: syt1 (homo sapiens) (aka synaptotagmin 1)
L: sox-2 (xenopus laevis) (sry-box 2 s homeolog (xenopus laevis)) (aka sry-box 2 s homeolog)
M: ssx2 (saccharomyces cerevisiae s288c) (aka rox3p)
N: synaptotagmin-1 (xenopus tropicalis) (aka synaptotagmin-1)
O: syt (xenopus laevis) (synaptotagmin 1 s homeolog (xenopus laevis)) (aka synaptotagmin 1 s homeolog)
P: None of the above. | [P; A; C] |
<Instruct>: Given the context 'The t(X;18)(p11.2;q11.2) chromosomal translocation commonly found in synovial sarcomas fuses the SYT gene on chromosome 18 to either of two similar genes, SSX1 or SSX2, on the X chromosome.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syt; ssx1; ssx2]
<Options>: A: ssx3 (homo sapiens) (aka ssx family member 3)
B: ssx family member 1 (homo sapiens) (aka ssx family member 1)
C: ssx (homo sapiens) (ssx family member 2b (homo sapiens)) (aka ssx family member 2b)
D: ssx2 (saccharomyces cerevisiae s288c) (aka rox3p)
E: ssxp2 (homo sapiens) (aka ssx family member 6, pseudogene)
F: ssxp1 (homo sapiens) (aka ssx family member 11, pseudogene)
G: srpx1 (xenopus laevis) (sushi repeat containing protein x-linked s homeolog (xenopus laevis)) (aka sushi repeat containing protein x-linked s homeolog)
H: ssx2 (homo sapiens) (aka ssx family member 2)
I: synaptotagmin 1 (xenopus tropicalis) (aka synaptotagmin 1)
J: protein ssuh2 homolog (xenopus laevis) (aka protein ssuh2 homolog)
K: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
L: syt (xenopus laevis) (synaptotagmin 1 s homeolog (xenopus laevis)) (aka synaptotagmin 1 s homeolog)
M: structure-specific endonuclease subunit slx1 homolog (caenorhabditis elegans) (aka structure-specific endonuclease subunit slx1 homolog)
N: synaptotagmin-1 (xenopus tropicalis) (aka synaptotagmin-1)
O: syt1 (homo sapiens) (aka synaptotagmin 1)
P: None of the above. | [P; B; H] |
<Instruct>: Given the context 'The t(X;18)(p11.2;q11.2) chromosomal translocation commonly found in synovial sarcomas fuses the SYT gene on chromosome 18 to either of two similar genes, SSX1 or SSX2, on the X chromosome.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syt; ssx1; ssx2]
<Options>: A: ssxp1 (homo sapiens) (aka ssx family member 11, pseudogene)
B: ssx family member 2 (homo sapiens) (aka ssx family member 2)
C: ssg1 (xenopus laevis) (coiled-coil domain containing 80 s homeolog (xenopus laevis)) (aka coiled-coil domain containing 80 s homeolog)
D: ssx (homo sapiens) (ssx family member 2b (homo sapiens)) (aka ssx family member 2b)
E: ssxp2 (homo sapiens) (aka ssx family member 6, pseudogene)
F: protein ssuh2 homolog (xenopus laevis) (aka protein ssuh2 homolog)
G: syt1 (homo sapiens) (aka synaptotagmin 1)
H: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
I: syt (xenopus tropicalis) (aka synaptotagmin 1)
J: sox-2 (xenopus laevis) (sry-box 2 s homeolog (xenopus laevis)) (aka sry-box 2 s homeolog)
K: synaptoporin (xenopus tropicalis) (aka synaptoporin)
L: synaptotagmin-1 (xenopus tropicalis) (aka synaptotagmin-1)
M: ssx1 (saccharomyces cerevisiae s288c) (aka srb7p)
N: structure-specific endonuclease subunit slx1 homolog (caenorhabditis elegans) (aka structure-specific endonuclease subunit slx1 homolog)
O: ssx family member 1 (homo sapiens) (aka ssx family member 1)
P: None of the above. | [P; O; B] |
<Instruct>: Given the context 'The SYT protein appears to act as a transcriptional co-activator and the SSX proteins as co-repressors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syt]
<Options>: A: syt1 (homo sapiens) (aka synaptotagmin 1)
B: synaptoporin (xenopus tropicalis) (aka synaptoporin)
C: synaptotagmin-1 (xenopus tropicalis) (aka synaptotagmin-1)
D: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
E: syt (xenopus laevis) (synaptotagmin 1 s homeolog (xenopus laevis)) (aka synaptotagmin 1 s homeolog)
F: None of the above. | [F] |
<Instruct>: Given the context 'The SYT protein has a novel conserved 54 amino acid domain at the N-terminus of the protein (the SNH domain) which is found in proteins from a wide variety of species, and a C-terminal domain, rich in glutamine, proline, glycine and tyrosine (the QPGY domain), which contains the transcriptional activator sequences.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syt]
<Options>: A: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
B: syt7 (homo sapiens) (aka synaptotagmin 7)
C: syt1 (homo sapiens) (aka synaptotagmin 1)
D: syt (xenopus tropicalis) (aka synaptotagmin 1)
E: synaptotagmin-1 (xenopus tropicalis) (aka synaptotagmin-1)
F: None of the above. | [F] |
<Instruct>: Given the context 'The C-terminal SSX domain present in SYT-SSX translocation protein contributes a transcriptional repressor domain to the protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syt]
<Options>: A: syt (xenopus laevis) (synaptotagmin 1 s homeolog (xenopus laevis)) (aka synaptotagmin 1 s homeolog)
B: syt1 (homo sapiens) (aka synaptotagmin 1)
C: syt7 (homo sapiens) (aka synaptotagmin 7)
D: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
E: syt (xenopus tropicalis) (aka synaptotagmin 1)
F: None of the above. | [F] |
<Instruct>: Given the context 'We demonstrate that the human homologue of the SNF2/Brahama protein BRM co-localizes with SYT and SYT-SSX in nuclear speckles, and also interacts with SYT and SYT-SSX proteins in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [snf2; brahama; brm; syt]
<Options>: A: snf1 (saccharomyces cerevisiae s288c) (aka amp-activated serine/threonine-protein kinase catalytic subunit snf1)
B: synaptoporin (xenopus tropicalis) (aka synaptoporin)
C: nedeba (homo sapiens) (aka atpase h+ transporting v0 subunit a1)
D: syt (xenopus laevis) (synaptotagmin 1 s homeolog (xenopus laevis)) (aka synaptotagmin 1 s homeolog)
E: snf2l2 (homo sapiens) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
F: bra (drosophila melanogaster) (breakage during anaphase (drosophila melanogaster)) (aka breakage during anaphase)
G: brt (mus musculus) (aka tyro3 protein tyrosine kinase 3)
H: brm (mus musculus) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
I: brm (drosophila melanogaster) (aka brahma)
J: brms1 like transcriptional repressor (bos taurus) (aka brms1 like transcriptional repressor)
K: snf2h (homo sapiens) (aka snf2 related chromatin remodeling atpase 5)
L: snf2l (homo sapiens) (aka snf2 related chromatin remodeling atpase 1)
M: synaptotagmin-1 (xenopus tropicalis) (aka synaptotagmin-1)
N: bravo (arabidopsis thaliana) (aka myb domain protein 56)
O: swi2 (saccharomyces cerevisiae s288c) (aka swi/snf catalytic subunit snf2)
P: syt1 (homo sapiens) (aka synaptotagmin 1)
Q: tmem179ba (danio rerio) (aka transmembrane protein 179ba)
R: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
S: nedesba (homo sapiens) (aka trafficking protein particle complex subunit 4)
T: None of the above. | [E; E; E; T] |
<Instruct>: Given the context 'We demonstrate that the human homologue of the SNF2/Brahama protein BRM co-localizes with SYT and SYT-SSX in nuclear speckles, and also interacts with SYT and SYT-SSX proteins in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [snf2; brahama; brm; syt]
<Options>: A: brp (mus musculus) (aka growth differentiation factor 5)
B: syt (xenopus tropicalis) (aka synaptotagmin 1)
C: snf2h (homo sapiens) (aka snf2 related chromatin remodeling atpase 5)
D: bora, aurora kinase a activator (rattus norvegicus) (aka bora, aurora kinase a activator)
E: snf2-beta (homo sapiens) (aka swi/snf related baf chromatin remodeling complex subunit atpase 4)
F: snf7-2 (homo sapiens) (aka charged multivesicular body protein 4b)
G: nedesba (homo sapiens) (aka trafficking protein particle complex subunit 4)
H: mbr (homo sapiens) (aka translocator protein)
I: syt7 (homo sapiens) (aka synaptotagmin 7)
J: smarcf2 (homo sapiens) (aka at-rich interaction domain 1b)
K: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
L: bravo (arabidopsis thaliana) (aka myb domain protein 56)
M: syt1 (homo sapiens) (aka synaptotagmin 1)
N: tmem179ba (danio rerio) (aka transmembrane protein 179ba)
O: brd (drosophila melanogaster) (brahma (drosophila melanogaster)) (aka brahma)
P: synaptotagmin-1 (xenopus tropicalis) (aka synaptotagmin-1)
Q: brt (mus musculus) (aka tyro3 protein tyrosine kinase 3)
R: brm (drosophila melanogaster) (aka brahma)
S: snf2l2 (homo sapiens) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
T: None of the above. | [S; S; S; T] |
<Instruct>: Given the context 'We demonstrate that the human homologue of the SNF2/Brahama protein BRM co-localizes with SYT and SYT-SSX in nuclear speckles, and also interacts with SYT and SYT-SSX proteins in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [snf2; brahama; brm; syt]
<Options>: A: syt1 (homo sapiens) (aka synaptotagmin 1)
B: brt (mus musculus) (aka tyro3 protein tyrosine kinase 3)
C: synaptotagmin-1 (xenopus tropicalis) (aka synaptotagmin-1)
D: snf2-beta (homo sapiens) (aka swi/snf related baf chromatin remodeling complex subunit atpase 4)
E: snf2 (saccharomyces cerevisiae s288c) (aka swi/snf catalytic subunit snf2)
F: brms1 like transcriptional repressor (bos taurus) (aka brms1 like transcriptional repressor)
G: brd (drosophila melanogaster) (brahma (drosophila melanogaster)) (aka brahma)
H: tmem179ba (danio rerio) (aka transmembrane protein 179ba)
I: bora, aurora kinase a activator (rattus norvegicus) (aka bora, aurora kinase a activator)
J: syt (xenopus tropicalis) (aka synaptotagmin 1)
K: synaptoporin (xenopus tropicalis) (aka synaptoporin)
L: brahma (arabidopsis thaliana) (aka transcription regulatory protein snf2)
M: smarcf2 (homo sapiens) (aka at-rich interaction domain 1b)
N: brm (mus musculus) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
O: brx1, biogenesis of ribosomes (mus musculus) (aka brx1, biogenesis of ribosomes)
P: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
Q: snf2h (homo sapiens) (aka snf2 related chromatin remodeling atpase 5)
R: nedeba (homo sapiens) (aka atpase h+ transporting v0 subunit a1)
S: snf2l2 (homo sapiens) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
T: None of the above. | [S; S; S; T] |
<Instruct>: Given the context 'We demonstrate that the human homologue of the SNF2/Brahama protein BRM co-localizes with SYT and SYT-SSX in nuclear speckles, and also interacts with SYT and SYT-SSX proteins in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [snf2; brahama; brm; syt]
<Options>: A: nedesba (homo sapiens) (aka trafficking protein particle complex subunit 4)
B: swi/snf catalytic subunit snf2 (saccharomyces cerevisiae s288c) (aka swi/snf catalytic subunit snf2)
C: bravo (arabidopsis thaliana) (aka myb domain protein 56)
D: brm (mus musculus) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
E: bra (drosophila melanogaster) (breakage during anaphase (drosophila melanogaster)) (aka breakage during anaphase)
F: snf1 (saccharomyces cerevisiae s288c) (aka amp-activated serine/threonine-protein kinase catalytic subunit snf1)
G: synaptoporin (xenopus tropicalis) (aka synaptoporin)
H: syt (xenopus laevis) (synaptotagmin 1 s homeolog (xenopus laevis)) (aka synaptotagmin 1 s homeolog)
I: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
J: br (mus musculus) (aka brachyrrhine)
K: snf2l2 (homo sapiens) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
L: smarcf2 (homo sapiens) (aka at-rich interaction domain 1b)
M: syt1 (xenopus tropicalis) (aka synaptotagmin 1)
N: brp (mus musculus) (aka growth differentiation factor 5)
O: brd (drosophila melanogaster) (brahma (drosophila melanogaster)) (aka brahma)
P: transmembrane protein 179ba (danio rerio) (aka transmembrane protein 179ba)
Q: mbr (homo sapiens) (aka translocator protein)
R: synaptotagmin-1 (xenopus tropicalis) (aka synaptotagmin-1)
S: snf7-2 (homo sapiens) (aka charged multivesicular body protein 4b)
T: None of the above. | [K; K; K; T] |
<Instruct>: Given the context 'We demonstrate that the human homologue of the SNF2/Brahama protein BRM co-localizes with SYT and SYT-SSX in nuclear speckles, and also interacts with SYT and SYT-SSX proteins in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syt]
<Options>: A: syt1 (xenopus tropicalis) (aka synaptotagmin 1)
B: synaptotagmin-1 (xenopus tropicalis) (aka synaptotagmin-1)
C: syt7 (homo sapiens) (aka synaptotagmin 7)
D: syt1 (homo sapiens) (aka synaptotagmin 1)
E: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
F: None of the above. | [F] |
<Instruct>: Given the context 'This interaction may provide an explanation of how the SYT protein activates gene transcription.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syt]
<Options>: A: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
B: syt7 (homo sapiens) (aka synaptotagmin 7)
C: synaptoporin (xenopus tropicalis) (aka synaptoporin)
D: synaptotagmin-1 (xenopus tropicalis) (aka synaptotagmin-1)
E: syt (xenopus laevis) (synaptotagmin 1 s homeolog (xenopus laevis)) (aka synaptotagmin 1 s homeolog)
F: None of the above. | [F] |
<Instruct>: Given the context 'Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [delta-isoforms of the multifunctional ca2+/calmodulin-dependent protein kinase]
<Options>: A: protein kinase c delta (xenopus tropicalis) (aka protein kinase c delta)
B: protein kinase c delta (homo sapiens) (aka protein kinase c delta)
C: calcium/calmodulin dependent protein kinase ii delta (gallus gallus) (aka calcium/calmodulin dependent protein kinase ii delta)
D: camk2d (homo sapiens) (aka calcium/calmodulin dependent protein kinase ii delta)
E: casein kinase 1 delta (homo sapiens) (aka casein kinase 1 delta)
F: None of the above. | [D] |
<Instruct>: Given the context 'In this study, we investigated the spectrum of CaMKII isoforms delta2, delta3, delta4, delta8, and delta9 in human striated muscle tissue.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [camkii isoforms delta2, delta3, delta4, delta8, and delta9]
<Options>: A: cki-delta (homo sapiens) (aka casein kinase 1 delta)
B: camkii (xenopus tropicalis) (calcium/calmodulin dependent protein kinase (cam kinase) ii delta (xenopus tropicalis)) (aka calcium/calmodulin dependent protein kinase (cam kinase) ii delta)
C: camkiid (drosophila melanogaster) (aka calcium/calmodulin-dependent protein kinase ii)
D: camkiinalpha (homo sapiens) (aka calcium/calmodulin dependent protein kinase ii alpha)
E: camk2d (homo sapiens) (aka calcium/calmodulin dependent protein kinase ii delta)
F: None of the above. | [E] |
<Instruct>: Given the context 'relative to the expression of glyceraldehyde-3-phosphate dehydrogenase in diseased hearts (101. 6+/-11.0% versus 64.9+/-9.9% in the nonfailing group; P < 0.05, n=6).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [glyceraldehyde-3-phosphate dehydrogenase]
<Options>: A: glyceraldehyde-3-phosphate dehydrogenase, spermatogenic (homo sapiens) (aka glyceraldehyde-3-phosphate dehydrogenase, spermatogenic)
B: gapdh (homo sapiens) (glyceraldehyde-3-phosphate dehydrogenase (homo sapiens)) (aka glyceraldehyde-3-phosphate dehydrogenase)
C: glyceraldehyde-3-phosphate dehydrogenase (gallus gallus) (aka glyceraldehyde-3-phosphate dehydrogenase)
D: phosphoglycerate dehydrogenase (homo sapiens) (aka phosphoglycerate dehydrogenase)
E: glyceraldehyde-3-phosphate dehydrogenase pseudogene (homo sapiens) (aka glyceraldehyde-3-phosphate dehydrogenase pseudogene)
F: None of the above. | [B] |
<Instruct>: Given the context 'At the protein level, by using a subclass-specific antibody, we observed a similar increase of a delta-CaMKII-specific signal (7.2+/-1.0 versus 3.8+/-0.7 optical density units in the nonfailing group; P < 0.05, n=4 through 6).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [delta-camkii]
<Options>: A: [d]-camkii (mus musculus) (aka calcium/calmodulin-dependent protein kinase ii, delta)
B: calcium/calmodulin dependent protein kinase ii delta (gallus gallus) (aka calcium/calmodulin dependent protein kinase ii delta)
C: camk2 (xenopus tropicalis) (calcium/calmodulin dependent protein kinase (cam kinase) ii delta (xenopus tropicalis)) (aka calcium/calmodulin dependent protein kinase (cam kinase) ii delta)
D: camkii (drosophila melanogaster) (aka calcium/calmodulin-dependent protein kinase ii)
E: calcium/calmodulin dependent protein kinase ii delta (homo sapiens) (aka calcium/calmodulin dependent protein kinase ii delta)
F: None of the above. | [E] |
<Instruct>: Given the context 'Our data characterize for the first time the delta-CaMKII isoform expression pattern in human hearts and demonstrate changes in this expression pattern in heart failure.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [delta-camkii]
<Options>: A: camk2d (homo sapiens) (aka calcium/calmodulin dependent protein kinase ii delta)
B: [d]-camkii (mus musculus) (aka calcium/calmodulin-dependent protein kinase ii, delta)
C: calcium/calmodulin dependent protein kinase ii delta (gallus gallus) (aka calcium/calmodulin dependent protein kinase ii delta)
D: camk2 (xenopus tropicalis) (calcium/calmodulin dependent protein kinase (cam kinase) ii delta (xenopus tropicalis)) (aka calcium/calmodulin dependent protein kinase (cam kinase) ii delta)
E: camkii (drosophila melanogaster) (aka calcium/calmodulin-dependent protein kinase ii)
F: None of the above. | [A] |
<Instruct>: Given the context 'Cloning and sequencing of the complete cDNA encoding the human insulin receptor related receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [insulin receptor related receptor]
<Options>: A: insulin receptor related receptor (homo sapiens) (aka insulin receptor related receptor)
B: insulin receptor related receptor (xenopus tropicalis) (aka insulin receptor related receptor)
C: igf2r (homo sapiens) (aka insulin like growth factor 2 receptor)
D: insulin receptor-related receptor (mus musculus) (aka insulin receptor-related receptor)
E: insulin receptor-related receptor (rattus norvegicus) (aka insulin receptor-related receptor)
F: None of the above. | [A] |
<Instruct>: Given the context 'The insulin receptor related receptor (IRR) is a heterotetrameric transmembrane receptor with intrinsic tyrosine kinase activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [insulin receptor related receptor; irr]
<Options>: A: il1r (homo sapiens) (aka interleukin 1 receptor type 1)
B: insulin receptor (homo sapiens) (aka insulin receptor)
C: insulin receptor-related receptor (rattus norvegicus) (aka insulin receptor-related receptor)
D: ifnr (homo sapiens) (aka interferon production regulator)
E: insulin receptor related receptor (sus scrofa) (aka insulin receptor related receptor)
F: ifngr1 (homo sapiens) (aka interferon gamma receptor 1)
G: il1r3 (homo sapiens) (aka interleukin 1 receptor accessory protein)
H: igf2r (homo sapiens) (aka insulin like growth factor 2 receptor)
I: insulin receptor related receptor (homo sapiens) (aka insulin receptor related receptor)
J: None of the above. | [I; I] |
<Instruct>: Given the context 'The insulin receptor related receptor (IRR) is a heterotetrameric transmembrane receptor with intrinsic tyrosine kinase activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [insulin receptor related receptor; irr]
<Options>: A: insulin receptor related receptor (homo sapiens) (aka insulin receptor related receptor)
B: il1r3 (homo sapiens) (aka interleukin 1 receptor accessory protein)
C: il1r (homo sapiens) (aka interleukin 1 receptor type 1)
D: igf2r (homo sapiens) (aka insulin like growth factor 2 receptor)
E: igfr (homo sapiens) (aka insulin like growth factor 1 receptor)
F: insr (homo sapiens) (aka insulin receptor)
G: ifnr (homo sapiens) (aka interferon production regulator)
H: insulin receptor-related receptor (mus musculus) (aka insulin receptor-related receptor)
I: ifngr1 (homo sapiens) (aka interferon gamma receptor 1)
J: None of the above. | [A; A] |
<Instruct>: Given the context 'The IRR shares large homology with the insulin and the insulin-like growth factor-1 (IGF-I) receptor with regard to amino acid sequence and protein structure.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [irr]
<Options>: A: insr (homo sapiens) (aka insulin receptor)
B: il1r3 (homo sapiens) (aka interleukin 1 receptor accessory protein)
C: ifngr (homo sapiens) (aka interferon gamma receptor 1)
D: insulin receptor related receptor (homo sapiens) (aka insulin receptor related receptor)
E: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
F: None of the above. | [D] |
<Instruct>: Given the context 'So far, only a partial human sequence containing the complete 3' end has been reported, although the full-length human IRR cDNA had been used for transfection studies and functional analysis of the receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [irr]
<Options>: A: insulin receptor related receptor (homo sapiens) (aka insulin receptor related receptor)
B: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
C: ifngr1 (homo sapiens) (aka interferon gamma receptor 1)
D: il1r3 (homo sapiens) (aka interleukin 1 receptor accessory protein)
E: insr (homo sapiens) (aka insulin receptor)
F: None of the above. | [A] |
<Instruct>: Given the context 'We have isolated a full-length human IRR cDNA and report on the 5' translated and untranslated region of the human IRR gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [irr]
<Options>: A: ifnr (homo sapiens) (aka interferon production regulator)
B: il1r3 (homo sapiens) (aka interleukin 1 receptor accessory protein)
C: insulin receptor related receptor (homo sapiens) (aka insulin receptor related receptor)
D: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
E: il1r (homo sapiens) (aka interleukin 1 receptor type 1)
F: None of the above. | [C] |
<Instruct>: Given the context 'The full length IRR sequence contains 4150 bases and shares a high degree of homology with the guinea pig IRR cDNA sequence and rat IRR sequences that had been reported earlier on by others.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [irr]
<Options>: A: ifngr1 (homo sapiens) (aka interferon gamma receptor 1)
B: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
C: ifnr (homo sapiens) (aka interferon production regulator)
D: irr (homo sapiens) (aka insulin receptor related receptor)
E: il1r3 (homo sapiens) (aka interleukin 1 receptor accessory protein)
F: None of the above. | [D] |
<Instruct>: Given the context 'Sequencing of the IRR cDNA revealed that the human IRR cDNA contains 341 bases corresponding to the IRR 5' end in addition to the bases that had been reported on before.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [irr]
<Options>: A: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
B: ifnr (homo sapiens) (aka interferon production regulator)
C: insr (homo sapiens) (aka insulin receptor)
D: ifngr (homo sapiens) (aka interferon gamma receptor 1)
E: insrr (homo sapiens) (aka insulin receptor related receptor)
F: None of the above. | [E] |
<Instruct>: Given the context 'The full length cDNA for the human IRR can now be used for functional expression studies and to elucidate the nature of the ligand for this receptor type.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [irr]
<Options>: A: il1r3 (homo sapiens) (aka interleukin 1 receptor accessory protein)
B: irr (homo sapiens) (aka insulin receptor related receptor)
C: ifnr (homo sapiens) (aka interferon production regulator)
D: il1r (homo sapiens) (aka interleukin 1 receptor type 1)
E: insr (homo sapiens) (aka insulin receptor)
F: None of the above. | [B] |
<Instruct>: Given the context 'The deduced amino acids sequence shows an overall homology of 48% with the human renal NPT1 protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [npt1]
<Options>: A: nrt1 (homo sapiens) (aka immunoglobulin superfamily member 9)
B: npat (homo sapiens) (aka nuclear protein, coactivator of histone transcription)
C: npt1 (homo sapiens) (aka solute carrier family 17 member 1)
D: slc-1 (homo sapiens) (aka melanin concentrating hormone receptor 1)
E: solute carrier family 1 member 2 (homo sapiens) (aka solute carrier family 1 member 2)
F: None of the above. | [C] |
<Instruct>: Given the context 'The deduced amino acids sequence shows an overall homology of 48% with the human renal NPT1 protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [npt1]
<Options>: A: npat (homo sapiens) (aka nuclear protein, coactivator of histone transcription)
B: slc-1 (homo sapiens) (aka melanin concentrating hormone receptor 1)
C: nrt1 (homo sapiens) (aka immunoglobulin superfamily member 9)
D: solute carrier family 1 member 2 (homo sapiens) (aka solute carrier family 1 member 2)
E: None of the above. | [E] |
<Instruct>: Given the context 'Thus, this gene may code for intestinal type NPT or closely related proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [intestinal type npt]
<Options>: A: nptn (homo sapiens) (aka neuroplastin)
B: npt4 (homo sapiens) (aka solute carrier family 17 member 3)
C: nptn-it1 (homo sapiens) (aka nptn intronic transcript 1)
D: npt2 (rattus norvegicus) (aka solute carrier family 34 member 1)
E: npt1 (homo sapiens) (aka solute carrier family 17 member 1)
F: None of the above. | [F] |
<Instruct>: Given the context 'Cutting edge: immature dendritic cells generated from monocytes in the presence of TGF-beta 1 express functional C-C chemokine receptor 6.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tgf-beta 1; c-c chemokine receptor 6]
<Options>: A: transforming growth factor beta 1 (bos taurus) (aka transforming growth factor beta 1)
B: il1-beta (homo sapiens) (aka interleukin 1 beta)
C: cc-ckr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
D: transforming growth factor beta receptor 1 (homo sapiens) (aka transforming growth factor beta receptor 1)
E: interferon beta 1 (homo sapiens) (aka interferon beta 1)
F: tgfb (homo sapiens) (aka transforming growth factor beta 1)
G: cxcr6 (homo sapiens) (aka c-x-c motif chemokine receptor 6)
H: c-c motif chemokine receptor 7 (homo sapiens) (aka c-c motif chemokine receptor 7)
I: c-c motif chemokine receptor 8 (homo sapiens) (aka c-c motif chemokine receptor 8)
J: None of the above. | [F; C] |
<Instruct>: Given the context 'Cutting edge: immature dendritic cells generated from monocytes in the presence of TGF-beta 1 express functional C-C chemokine receptor 6.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tgf-beta 1; c-c chemokine receptor 6]
<Options>: A: c-x-c motif chemokine receptor 6 (homo sapiens) (aka c-x-c motif chemokine receptor 6)
B: c-c motif chemokine receptor 7 (homo sapiens) (aka c-c motif chemokine receptor 7)
C: interferon beta 1 (homo sapiens) (aka interferon beta 1)
D: transforming growth factor beta 1 (xenopus tropicalis) (aka transforming growth factor beta 1)
E: cmkbr6 (homo sapiens) (aka c-c motif chemokine receptor 6)
F: transforming growth factor beta receptor 1 (homo sapiens) (aka transforming growth factor beta receptor 1)
G: transforming growth factor beta 1 (homo sapiens) (aka transforming growth factor beta 1)
H: c-c motif chemokine receptor 8 (homo sapiens) (aka c-c motif chemokine receptor 8)
I: il1-beta (homo sapiens) (aka interleukin 1 beta)
J: None of the above. | [G; E] |
<Instruct>: Given the context 'Although CD34+ progenitor-derived immature dendritic cells (DCs) express CCR6, several recent studies reported that monocyte-derived immature DCs do not do so.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ccr6]
<Options>: A: cxcr6 (homo sapiens) (aka c-x-c motif chemokine receptor 6)
B: ccr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
C: c-c ckr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
D: None of the above. | [C] |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gm-csf; il-4; tgf-beta 1; liver and activation-regulated chemokine]
<Options>: A: c-x-c motif chemokine ligand 3 (homo sapiens) (aka c-x-c motif chemokine ligand 3)
B: tgfb1 (homo sapiens) (aka transforming growth factor beta 1)
C: transforming growth factor beta receptor 1 (homo sapiens) (aka transforming growth factor beta receptor 1)
D: il-4 (homo sapiens) (aka interleukin 4)
E: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
F: ld78 (homo sapiens) (c-c motif chemokine ligand 3 (homo sapiens)) (aka c-c motif chemokine ligand 3)
G: c-c motif chemokine ligand 26 (homo sapiens) (aka c-c motif chemokine ligand 26)
H: c-x-c motif chemokine ligand 13 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
I: colony stimulating factor 3 (homo sapiens) (aka colony stimulating factor 3)
J: interferon beta 1 (homo sapiens) (aka interferon beta 1)
K: multi-csf (homo sapiens) (aka interleukin 3)
L: il-4 (bos taurus) (aka interleukin 4)
M: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
N: ccl16 (homo sapiens) (aka c-c motif chemokine ligand 16)
O: gm-csf (mus musculus) (aka colony stimulating factor 2 (granulocyte-macrophage))
P: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
Q: gmcsf (homo sapiens) (aka colony stimulating factor 2)
R: transforming growth factor beta 1 (bos taurus) (aka transforming growth factor beta 1)
S: il1-beta (homo sapiens) (aka interleukin 1 beta)
T: csf1 (homo sapiens) (aka colony stimulating factor 1)
U: None of the above. | [Q; D; B; U] |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gm-csf; il-4; tgf-beta 1; liver and activation-regulated chemokine]
<Options>: A: tgfb1 (homo sapiens) (aka transforming growth factor beta 1)
B: multi-csf (homo sapiens) (aka interleukin 3)
C: colony stimulating factor 3 (homo sapiens) (aka colony stimulating factor 3)
D: interferon beta 1 (homo sapiens) (aka interferon beta 1)
E: c-c motif chemokine ligand 26 (homo sapiens) (aka c-c motif chemokine ligand 26)
F: transforming growth factor beta receptor 1 (homo sapiens) (aka transforming growth factor beta receptor 1)
G: gm-csf (mus musculus) (aka colony stimulating factor 2 (granulocyte-macrophage))
H: c-x-c motif chemokine ligand 3 (homo sapiens) (aka c-x-c motif chemokine ligand 3)
I: csf1 (homo sapiens) (aka colony stimulating factor 1)
J: il1-beta (homo sapiens) (aka interleukin 1 beta)
K: ld78 (homo sapiens) (c-c motif chemokine ligand 3 (homo sapiens)) (aka c-c motif chemokine ligand 3)
L: ccl16 (homo sapiens) (aka c-c motif chemokine ligand 16)
M: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
N: c-x-c motif chemokine ligand 13 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
O: il-4 (bos taurus) (aka interleukin 4)
P: transforming growth factor beta 1 (bos taurus) (aka transforming growth factor beta 1)
Q: il-4 (homo sapiens) (aka interleukin 4)
R: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
S: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
T: None of the above. | [T; Q; A; T] |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gm-csf; il-4; tgf-beta 1; liver and activation-regulated chemokine]
<Options>: A: transforming growth factor beta 1 (homo sapiens) (aka transforming growth factor beta 1)
B: il4 (homo sapiens) (aka interleukin 4)
C: interleukin 5 (homo sapiens) (aka interleukin 5)
D: interleukin 4 (bos taurus) (aka interleukin 4)
E: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
F: il1-beta (homo sapiens) (aka interleukin 1 beta)
G: 6ckine (homo sapiens) (aka c-c motif chemokine ligand 21)
H: interferon beta 1 (homo sapiens) (aka interferon beta 1)
I: ccl16 (homo sapiens) (aka c-c motif chemokine ligand 16)
J: csf2 (homo sapiens) (aka colony stimulating factor 2)
K: gm-csf (mus musculus) (aka colony stimulating factor 2 (granulocyte-macrophage))
L: ld78 (homo sapiens) (c-c motif chemokine ligand 3 (homo sapiens)) (aka c-c motif chemokine ligand 3)
M: transforming growth factor beta 1 (bos taurus) (aka transforming growth factor beta 1)
N: transforming growth factor beta receptor 1 (homo sapiens) (aka transforming growth factor beta receptor 1)
O: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
P: c-x-c motif chemokine ligand 13 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
Q: colony stimulating factor 3 (homo sapiens) (aka colony stimulating factor 3)
R: multi-csf (homo sapiens) (aka interleukin 3)
S: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
T: csf1 (homo sapiens) (aka colony stimulating factor 1)
U: None of the above. | [J; B; A; U] |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gm-csf; il-4; tgf-beta 1; liver and activation-regulated chemokine]
<Options>: A: il1-beta (homo sapiens) (aka interleukin 1 beta)
B: multi-csf (homo sapiens) (aka interleukin 3)
C: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2)
D: interferon beta 1 (homo sapiens) (aka interferon beta 1)
E: c-c motif chemokine ligand 13 (homo sapiens) (aka c-c motif chemokine ligand 13)
F: transforming growth factor beta 1 (bos taurus) (aka transforming growth factor beta 1)
G: il4 (bos taurus) (aka interleukin 4)
H: csf1 (homo sapiens) (aka colony stimulating factor 1)
I: c-c motif chemokine ligand 26 (homo sapiens) (aka c-c motif chemokine ligand 26)
J: c-x-c motif chemokine ligand 3 (homo sapiens) (aka c-x-c motif chemokine ligand 3)
K: interleukin 4 (homo sapiens) (aka interleukin 4)
L: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
M: interleukin 5 (homo sapiens) (aka interleukin 5)
N: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
O: transforming growth factor beta 1 (xenopus tropicalis) (aka transforming growth factor beta 1)
P: gm-csf (mus musculus) (aka colony stimulating factor 2 (granulocyte-macrophage))
Q: ccl16 (homo sapiens) (aka c-c motif chemokine ligand 16)
R: c-x-c motif chemokine ligand 13 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
S: tgf-beta1 (homo sapiens) (aka transforming growth factor beta 1)
T: colony stimulating factor 3 (homo sapiens) (aka colony stimulating factor 3)
U: None of the above. | [C; K; S; U] |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gm-csf; il-4; tgf-beta 1; liver and activation-regulated chemokine]
<Options>: A: transforming growth factor beta 1 (xenopus tropicalis) (aka transforming growth factor beta 1)
B: tgfb1 (homo sapiens) (aka transforming growth factor beta 1)
C: transforming growth factor beta receptor 1 (homo sapiens) (aka transforming growth factor beta receptor 1)
D: c-x-c motif chemokine ligand 13 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
E: interferon beta 1 (homo sapiens) (aka interferon beta 1)
F: csf2 (homo sapiens) (aka colony stimulating factor 2)
G: transforming growth factor beta 1 (bos taurus) (aka transforming growth factor beta 1)
H: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
I: 6ckine (homo sapiens) (aka c-c motif chemokine ligand 21)
J: c-x-c motif chemokine ligand 3 (homo sapiens) (aka c-x-c motif chemokine ligand 3)
K: interleukin 5 (homo sapiens) (aka interleukin 5)
L: interleukin 4 (bos taurus) (aka interleukin 4)
M: ld78 (homo sapiens) (c-c motif chemokine ligand 3 (homo sapiens)) (aka c-c motif chemokine ligand 3)
N: colony stimulating factor 1 (homo sapiens) (aka colony stimulating factor 1)
O: interleukin 4 (homo sapiens) (aka interleukin 4)
P: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
Q: c-c motif chemokine ligand 13 (homo sapiens) (aka c-c motif chemokine ligand 13)
R: colony stimulating factor 3 (homo sapiens) (aka colony stimulating factor 3)
S: multi-csf (homo sapiens) (aka interleukin 3)
T: gm-csf (mus musculus) (aka colony stimulating factor 2 (granulocyte-macrophage))
U: None of the above. | [F; O; B; U] |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [larc; macrophage inflammatory protein-3 alpha]
<Options>: A: lar (homo sapiens) (aka protein tyrosine phosphatase receptor type f)
B: larc (mus musculus) (aka c-c motif chemokine ligand 20)
C: larc (homo sapiens) (aka c-c motif chemokine ligand 20)
D: lncarsr (homo sapiens) (aka lncrna regulator of akt signaling associated with hcc and rcc)
E: c-x-c motif chemokine ligand 3 (homo sapiens) (aka c-x-c motif chemokine ligand 3)
F: lnccrla (homo sapiens) (aka myo1d divergent transcript)
G: mip-3 (homo sapiens) (aka c-c motif chemokine ligand 23)
H: c-c motif chemokine ligand 3 (homo sapiens) (aka c-c motif chemokine ligand 3)
I: mcp-3 (homo sapiens) (aka c-c motif chemokine ligand 7)
J: None of the above. | [C; C] |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [larc; macrophage inflammatory protein-3 alpha]
<Options>: A: mip-3 (homo sapiens) (aka c-c motif chemokine ligand 23)
B: c-x-c motif chemokine ligand 3 (homo sapiens) (aka c-x-c motif chemokine ligand 3)
C: lncarsr (homo sapiens) (aka lncrna regulator of akt signaling associated with hcc and rcc)
D: lnc-rhl (homo sapiens) (aka lncrna regulator of hepatic lineages 1)
E: lar (homo sapiens) (aka protein tyrosine phosphatase receptor type f)
F: larc (homo sapiens) (aka c-c motif chemokine ligand 20)
G: lncsrlr (homo sapiens) (aka lncrna sorafenib resistance in renal cell carcinoma associated)
H: ccl3 (homo sapiens) (aka c-c motif chemokine ligand 3)
I: mcp-3 (homo sapiens) (aka c-c motif chemokine ligand 7)
J: None of the above. | [F; F] |
<Instruct>: Given the context 'These immature DCs expressed one class of high-affinity binding sites for LARC, and expressed both CCR6 mRNA and protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [larc; ccr6]
<Options>: A: lard (homo sapiens) (aka tnf receptor superfamily member 25)
B: larc (mus musculus) (aka c-c motif chemokine ligand 20)
C: c-x-c motif chemokine receptor 6 (homo sapiens) (aka c-x-c motif chemokine receptor 6)
D: lar1 (homo sapiens) (aka la ribonucleoprotein 1, translational regulator)
E: cc-ckr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
F: c-c motif chemokine receptor 6 (homo sapiens) (aka c-c motif chemokine receptor 6)
G: lnccrla (homo sapiens) (aka myo1d divergent transcript)
H: larc (homo sapiens) (aka c-c motif chemokine ligand 20)
I: None of the above. | [H; F] |
<Instruct>: Given the context 'These immature DCs expressed one class of high-affinity binding sites for LARC, and expressed both CCR6 mRNA and protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [larc; ccr6]
<Options>: A: c-c ckr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
B: c-x-c motif chemokine receptor 6 (homo sapiens) (aka c-x-c motif chemokine receptor 6)
C: ccr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
D: lard (homo sapiens) (aka tnf receptor superfamily member 25)
E: larc (homo sapiens) (aka c-c motif chemokine ligand 20)
F: lar (homo sapiens) (aka protein tyrosine phosphatase receptor type f)
G: larc (mus musculus) (aka c-c motif chemokine ligand 20)
H: lnc-rhl (homo sapiens) (aka lncrna regulator of hepatic lineages 1)
I: None of the above. | [E; A] |
<Instruct>: Given the context 'These immature DCs expressed one class of high-affinity binding sites for LARC, and expressed both CCR6 mRNA and protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [larc; ccr6]
<Options>: A: lard (homo sapiens) (aka tnf receptor superfamily member 25)
B: lnc-rhl (homo sapiens) (aka lncrna regulator of hepatic lineages 1)
C: c-c ckr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
D: ccr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
E: larc (mus musculus) (aka c-c motif chemokine ligand 20)
F: c-x-c motif chemokine receptor 6 (homo sapiens) (aka c-x-c motif chemokine receptor 6)
G: lar (homo sapiens) (aka protein tyrosine phosphatase receptor type f)
H: None of the above. | [H; C] |
<Instruct>: Given the context 'Therefore, LARC-CCR6 interaction presumably also contributes to the regulation of trafficking of monocyte-derived DCs, and utilization of TGF-beta can potentially provide a ready source of CCR6+ monocyte-derived DCs for therapeutic purposes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [larc; ccr6]
<Options>: A: c-x-c motif chemokine receptor 6 (homo sapiens) (aka c-x-c motif chemokine receptor 6)
B: ccr6 (homo sapiens) (aka c-c motif chemokine receptor 6)
C: lard (homo sapiens) (aka tnf receptor superfamily member 25)
D: ccr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
E: lncarsr (homo sapiens) (aka lncrna regulator of akt signaling associated with hcc and rcc)
F: lar1 (homo sapiens) (aka la ribonucleoprotein 1, translational regulator)
G: larc (homo sapiens) (aka c-c motif chemokine ligand 20)
H: lnccrla (homo sapiens) (aka myo1d divergent transcript)
I: None of the above. | [G; B] |
<Instruct>: Given the context 'Therefore, LARC-CCR6 interaction presumably also contributes to the regulation of trafficking of monocyte-derived DCs, and utilization of TGF-beta can potentially provide a ready source of CCR6+ monocyte-derived DCs for therapeutic purposes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [larc; ccr6]
<Options>: A: lncarsr (homo sapiens) (aka lncrna regulator of akt signaling associated with hcc and rcc)
B: lard (homo sapiens) (aka tnf receptor superfamily member 25)
C: larc (homo sapiens) (aka c-c motif chemokine ligand 20)
D: lnccrla (homo sapiens) (aka myo1d divergent transcript)
E: c-x-c motif chemokine receptor 6 (homo sapiens) (aka c-x-c motif chemokine receptor 6)
F: c-c motif chemokine receptor 6 (homo sapiens) (aka c-c motif chemokine receptor 6)
G: lnc-rhl (homo sapiens) (aka lncrna regulator of hepatic lineages 1)
H: ccr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
I: None of the above. | [C; F] |
<Instruct>: Given the context 'Identification and characterization of PKNbeta, a novel isoform of protein kinase PKN: expression and arachidonic acid dependency are different from those of PKNalpha.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pknbeta; pknalpha]
<Options>: A: pkn-alpha (homo sapiens) (aka protein kinase n1)
B: pkn (drosophila melanogaster) (protein kinase n (drosophila melanogaster)) (aka protein kinase n)
C: pkbbeta (homo sapiens) (aka akt serine/threonine kinase 2)
D: prkr (homo sapiens) (aka eukaryotic translation initiation factor 2 alpha kinase 2)
E: pkgb (homo sapiens) (aka junction plakoglobin)
F: cdc42 binding protein kinase beta (bos taurus) (aka cdc42 binding protein kinase beta)
G: pkn-alpha (xenopus laevis) (aka protein kinase n1 l homeolog)
H: protein kinase c, beta (rattus norvegicus) (aka protein kinase c, beta)
I: prkn (homo sapiens) (aka parkin rbr e3 ubiquitin protein ligase)
J: pkn (homo sapiens) (aka protein kinase n1)
K: None of the above. | [K; J] |
<Instruct>: Given the context 'Identification and characterization of PKNbeta, a novel isoform of protein kinase PKN: expression and arachidonic acid dependency are different from those of PKNalpha.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pknbeta; pknalpha]
<Options>: A: pkgb (homo sapiens) (aka junction plakoglobin)
B: prkr (homo sapiens) (aka eukaryotic translation initiation factor 2 alpha kinase 2)
C: cdc42 binding protein kinase beta (bos taurus) (aka cdc42 binding protein kinase beta)
D: pku-alpha (homo sapiens) (aka tousled like kinase 2)
E: pkn-alpha (homo sapiens) (aka protein kinase n1)
F: protein kinase c, beta (rattus norvegicus) (aka protein kinase c, beta)
G: pkbb (homo sapiens) (aka akt serine/threonine kinase 2)
H: pkn (drosophila melanogaster) (protein kinase n (drosophila melanogaster)) (aka protein kinase n)
I: pkn-alpha (xenopus tropicalis) (aka protein kinase n1)
J: None of the above. | [J; E] |
<Instruct>: Given the context 'The cDNA clone encoding a novel isoform of protein kinase PKN, termed PKNbeta, was isolated from a HeLa cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pknbeta]
<Options>: A: cdc42 binding protein kinase beta (bos taurus) (aka cdc42 binding protein kinase beta)
B: protein kinase c beta (bos taurus) (aka protein kinase c beta)
C: protein kinase c, beta (rattus norvegicus) (aka protein kinase c, beta)
D: pkgb (homo sapiens) (aka junction plakoglobin)
E: pkc-beta (homo sapiens) (aka protein kinase c beta)
F: None of the above. | [F] |
<Instruct>: Given the context 'PKNbeta had high sequence homology with PKNalpha, originally isolated PKN, especially in the repeats of charged amino acid-rich region with leucine-zipper like sequences (CZ region/HR1), in the carboxyl-terminal catalytic domain, and in approximately 130 amino acid stretch (D region/HR2), located between CZ region/HR1 and the catalytic domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pknbeta; pknalpha]
<Options>: A: pkgb (homo sapiens) (aka junction plakoglobin)
B: pkn-alpha (homo sapiens) (aka protein kinase n1)
C: pkn2 (homo sapiens) (aka protein kinase n2)
D: prkcb (homo sapiens) (aka protein kinase c beta)
E: pku-alpha (homo sapiens) (aka tousled like kinase 2)
F: protein kinase c, beta (rattus norvegicus) (aka protein kinase c, beta)
G: pkbb (homo sapiens) (aka akt serine/threonine kinase 2)
H: prkn (homo sapiens) (aka parkin rbr e3 ubiquitin protein ligase)
I: pkn (homo sapiens) (aka protein kinase n1)
J: prkr (homo sapiens) (aka eukaryotic translation initiation factor 2 alpha kinase 2)
K: None of the above. | [K; I] |
<Instruct>: Given the context 'PKNbeta had high sequence homology with PKNalpha, originally isolated PKN, especially in the repeats of charged amino acid-rich region with leucine-zipper like sequences (CZ region/HR1), in the carboxyl-terminal catalytic domain, and in approximately 130 amino acid stretch (D region/HR2), located between CZ region/HR1 and the catalytic domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pknbeta; pknalpha]
<Options>: A: pkbb (homo sapiens) (aka akt serine/threonine kinase 2)
B: pku-alpha (homo sapiens) (aka tousled like kinase 2)
C: protein kinase c beta (bos taurus) (aka protein kinase c beta)
D: pkn2 (homo sapiens) (aka protein kinase n2)
E: prkn (homo sapiens) (aka parkin rbr e3 ubiquitin protein ligase)
F: pkn (homo sapiens) (aka protein kinase n1)
G: cdc42 binding protein kinase beta (bos taurus) (aka cdc42 binding protein kinase beta)
H: pkn-alpha (homo sapiens) (aka protein kinase n1)
I: protein kinase c beta (homo sapiens) (aka protein kinase c beta)
J: pkn-alpha (xenopus laevis) (aka protein kinase n1 l homeolog)
K: None of the above. | [K; F] |
<Instruct>: Given the context 'However, the amino acid sequence of PKNbeta differed from that of PKNalpha in the region immediately amino-terminal to the catalytic domain, which contained two distinct proline-rich sequences consistent with the class II consensus sequence, PXXPXR, for binding to SH3 domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pknbeta; pknalpha]
<Options>: A: protein kinase c beta (bos taurus) (aka protein kinase c beta)
B: prkn (homo sapiens) (aka parkin rbr e3 ubiquitin protein ligase)
C: pkgb (homo sapiens) (aka junction plakoglobin)
D: protein kinase c, beta (rattus norvegicus) (aka protein kinase c, beta)
E: pkn1 (homo sapiens) (aka protein kinase n1)
F: pkbb (homo sapiens) (aka akt serine/threonine kinase 2)
G: pkn (drosophila melanogaster) (protein kinase n (drosophila melanogaster)) (aka protein kinase n)
H: pkn-alpha (xenopus tropicalis) (aka protein kinase n1)
I: pkn-alpha (xenopus laevis) (aka protein kinase n1 l homeolog)
J: cdc42 binding protein kinase beta (bos taurus) (aka cdc42 binding protein kinase beta)
K: None of the above. | [K; E] |
<Instruct>: Given the context 'However, the amino acid sequence of PKNbeta differed from that of PKNalpha in the region immediately amino-terminal to the catalytic domain, which contained two distinct proline-rich sequences consistent with the class II consensus sequence, PXXPXR, for binding to SH3 domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pknbeta; pknalpha]
<Options>: A: protein kinase c beta (bos taurus) (aka protein kinase c beta)
B: pkn (drosophila melanogaster) (protein kinase n (drosophila melanogaster)) (aka protein kinase n)
C: pkc-beta (homo sapiens) (aka protein kinase c beta)
D: pkgb (homo sapiens) (aka junction plakoglobin)
E: protein kinase c, beta (rattus norvegicus) (aka protein kinase c, beta)
F: prkr (homo sapiens) (aka eukaryotic translation initiation factor 2 alpha kinase 2)
G: pkn-alpha (homo sapiens) (aka protein kinase n1)
H: pkbb (homo sapiens) (aka akt serine/threonine kinase 2)
I: pkn-alpha (xenopus tropicalis) (aka protein kinase n1)
J: pku-alpha (homo sapiens) (aka tousled like kinase 2)
K: None of the above. | [K; G] |
<Instruct>: Given the context 'Distribution of PKNbeta differed from that of PKNalpha in the following two respects: (1) Northern blotting indicated that PKNbeta mRNA could not be detected in human adult tissues, but was expressed abundantly in human cancer cell lines; (2) immunochemical analysis indicated that PKNbeta localized in nucleus and perinuclear Golgi apparatus, and was almost absent in cytoplasmic region in NIH3T3 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pknbeta; pknalpha]
<Options>: A: protein kinase c, beta (rattus norvegicus) (aka protein kinase c, beta)
B: pkn-alpha (xenopus tropicalis) (aka protein kinase n1)
C: protein kinase c beta (bos taurus) (aka protein kinase c beta)
D: pku-alpha (homo sapiens) (aka tousled like kinase 2)
E: cdc42 binding protein kinase beta (bos taurus) (aka cdc42 binding protein kinase beta)
F: pkn-alpha (homo sapiens) (aka protein kinase n1)
G: pkn2 (homo sapiens) (aka protein kinase n2)
H: pkgb (homo sapiens) (aka junction plakoglobin)
I: pkn-alpha (xenopus laevis) (aka protein kinase n1 l homeolog)
J: None of the above. | [J; F] |
<Instruct>: Given the context 'Distribution of PKNbeta differed from that of PKNalpha in the following two respects: (1) Northern blotting indicated that PKNbeta mRNA could not be detected in human adult tissues, but was expressed abundantly in human cancer cell lines; (2) immunochemical analysis indicated that PKNbeta localized in nucleus and perinuclear Golgi apparatus, and was almost absent in cytoplasmic region in NIH3T3 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pknbeta; pknalpha]
<Options>: A: pkn-alpha (xenopus laevis) (aka protein kinase n1 l homeolog)
B: prkn (homo sapiens) (aka parkin rbr e3 ubiquitin protein ligase)
C: pkn1 (homo sapiens) (aka protein kinase n1)
D: pkbb (homo sapiens) (aka akt serine/threonine kinase 2)
E: protein kinase c, beta (rattus norvegicus) (aka protein kinase c, beta)
F: pku-alpha (homo sapiens) (aka tousled like kinase 2)
G: cdc42 binding protein kinase beta (bos taurus) (aka cdc42 binding protein kinase beta)
H: protein kinase c beta (bos taurus) (aka protein kinase c beta)
I: protein kinase c beta (homo sapiens) (aka protein kinase c beta)
J: pkn-alpha (xenopus tropicalis) (aka protein kinase n1)
K: None of the above. | [K; C] |
<Instruct>: Given the context 'Recombinant PKNbeta expressed in COS7 cells displayed autophosphorylation and peptide kinase activity, but was found to be significantly less responsive to arachidonic acid than PKNalpha.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pknbeta; pknalpha]
<Options>: A: pkn-alpha (xenopus tropicalis) (aka protein kinase n1)
B: protein kinase c beta (bos taurus) (aka protein kinase c beta)
C: pkgb (homo sapiens) (aka junction plakoglobin)
D: pkbb (homo sapiens) (aka akt serine/threonine kinase 2)
E: pkn (homo sapiens) (aka protein kinase n1)
F: pkn-alpha (xenopus laevis) (aka protein kinase n1 l homeolog)
G: prkcb (homo sapiens) (aka protein kinase c beta)
H: pkn (drosophila melanogaster) (protein kinase n (drosophila melanogaster)) (aka protein kinase n)
I: protein kinase c, beta (rattus norvegicus) (aka protein kinase c, beta)
J: pkn2 (homo sapiens) (aka protein kinase n2)
K: None of the above. | [K; E] |
<Instruct>: Given the context 'Recombinant PKNbeta expressed in COS7 cells displayed autophosphorylation and peptide kinase activity, but was found to be significantly less responsive to arachidonic acid than PKNalpha.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pknbeta; pknalpha]
<Options>: A: pkbb (homo sapiens) (aka akt serine/threonine kinase 2)
B: pkn-alpha (xenopus tropicalis) (aka protein kinase n1)
C: pkn2 (homo sapiens) (aka protein kinase n2)
D: pkn (drosophila melanogaster) (protein kinase n (drosophila melanogaster)) (aka protein kinase n)
E: protein kinase c, beta (rattus norvegicus) (aka protein kinase c, beta)
F: cdc42 binding protein kinase beta (bos taurus) (aka cdc42 binding protein kinase beta)
G: pkn-alpha (homo sapiens) (aka protein kinase n1)
H: prkn (homo sapiens) (aka parkin rbr e3 ubiquitin protein ligase)
I: protein kinase c beta (bos taurus) (aka protein kinase c beta)
J: pkc-beta (homo sapiens) (aka protein kinase c beta)
K: None of the above. | [K; G] |
<Instruct>: Given the context 'Coats' disease of the retina (unilateral retinal telangiectasis) caused by somatic mutation in the NDP gene: a role for norrin in retinal angiogenesis.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ndp; norrin]
<Options>: A: ndc1 transmembrane nucleoporin (homo sapiens) (aka ndc1 transmembrane nucleoporin)
B: ndp (rattus norvegicus) (aka norrin cystine knot growth factor ndp)
C: neuritin 1-like (rattus norvegicus) (aka neuritin 1-like)
D: ndpp (homo sapiens) (aka caspase recruitment domain family member 8)
E: norbin (rattus norvegicus) (aka neurochondrin)
F: ndp (xenopus tropicalis) (aka norrin cystine knot growth factor ndp)
G: norrin cystine knot growth factor ndp (homo sapiens) (aka norrin cystine knot growth factor ndp)
H: norrin cystine knot growth factor ndp (rattus norvegicus) (aka norrin cystine knot growth factor ndp)
I: ninein-like (rattus norvegicus) (aka ninein-like)
J: None of the above. | [G; G] |
<Instruct>: Given the context 'Coats' disease of the retina (unilateral retinal telangiectasis) caused by somatic mutation in the NDP gene: a role for norrin in retinal angiogenesis.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ndp; norrin]
<Options>: A: nor-2 (rattus norvegicus) (aka nuclear receptor subfamily 4, group a, member 3)
B: naked cuticle homolog 1 (xenopus tropicalis) (aka naked cuticle homolog 1)
C: ndp (homo sapiens) (aka norrin cystine knot growth factor ndp)
D: ndp (rattus norvegicus) (aka norrin cystine knot growth factor ndp)
E: norbin (rattus norvegicus) (aka neurochondrin)
F: ndnf (homo sapiens) (aka neuron derived neurotrophic factor)
G: ndpp (homo sapiens) (aka caspase recruitment domain family member 8)
H: ninein-like (rattus norvegicus) (aka ninein-like)
I: norrin cystine knot growth factor ndp (rattus norvegicus) (aka norrin cystine knot growth factor ndp)
J: None of the above. | [C; C] |
<Instruct>: Given the context 'Both carried a missense mutation within the NDP gene on chromosome Xp11.2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ndp]
<Options>: A: ndp (homo sapiens) (aka norrin cystine knot growth factor ndp)
B: ndc1 transmembrane nucleoporin (homo sapiens) (aka ndc1 transmembrane nucleoporin)
C: ndp (xenopus tropicalis) (aka norrin cystine knot growth factor ndp)
D: ndnf (homo sapiens) (aka neuron derived neurotrophic factor)
E: ndp (rattus norvegicus) (aka norrin cystine knot growth factor ndp)
F: None of the above. | [A] |
<Instruct>: Given the context 'Both carried a missense mutation within the NDP gene on chromosome Xp11.2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ndp]
<Options>: A: ndc1 transmembrane nucleoporin (homo sapiens) (aka ndc1 transmembrane nucleoporin)
B: ndnf (homo sapiens) (aka neuron derived neurotrophic factor)
C: ndp (rattus norvegicus) (aka norrin cystine knot growth factor ndp)
D: ndp (xenopus tropicalis) (aka norrin cystine knot growth factor ndp)
E: None of the above. | [E] |
<Instruct>: Given the context 'Subsequently analysis of the retinas of nine enucleated eyes from males with Coats' disease demonstrated in one a somatic mutation in the NDP gene which was not present within non-retinal tissue.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ndp]
<Options>: A: ndpkd (homo sapiens) (aka nme/nm23 nucleoside diphosphate kinase 4)
B: norrin cystine knot growth factor ndp (homo sapiens) (aka norrin cystine knot growth factor ndp)
C: ndp (rattus norvegicus) (aka norrin cystine knot growth factor ndp)
D: ndp (xenopus tropicalis) (aka norrin cystine knot growth factor ndp)
E: ndn (homo sapiens) (aka necdin, mage family member)
F: None of the above. | [B] |
<Instruct>: Given the context 'We suggest that Coats' telangiectasis is secondary to somatic mutation in the NDP gene which results in a deficiency of norrin (the protein product of the NDP gene) within the developing retina.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ndp; norrin]
<Options>: A: ndc1 transmembrane nucleoporin (homo sapiens) (aka ndc1 transmembrane nucleoporin)
B: nrn (rattus norvegicus) (aka neuritin 1)
C: ndp (xenopus tropicalis) (aka norrin cystine knot growth factor ndp)
D: connectin (rattus norvegicus) (aka titin)
E: ninein-like (rattus norvegicus) (aka ninein-like)
F: naked cuticle homolog 1 (xenopus tropicalis) (aka naked cuticle homolog 1)
G: ndp (rattus norvegicus) (aka norrin cystine knot growth factor ndp)
H: ndp (homo sapiens) (aka norrin cystine knot growth factor ndp)
I: nor-2 (rattus norvegicus) (aka nuclear receptor subfamily 4, group a, member 3)
J: None of the above. | [H; H] |
<Instruct>: Given the context 'We suggest that Coats' telangiectasis is secondary to somatic mutation in the NDP gene which results in a deficiency of norrin (the protein product of the NDP gene) within the developing retina.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ndp; norrin]
<Options>: A: norrin cystine knot growth factor ndp (homo sapiens) (aka norrin cystine knot growth factor ndp)
B: connectin (rattus norvegicus) (aka titin)
C: nynrin (rattus norvegicus) (aka nyn domain and retroviral integrase containing)
D: nrn (rattus norvegicus) (aka neuritin 1)
E: ninein-like (rattus norvegicus) (aka ninein-like)
F: ndnf (homo sapiens) (aka neuron derived neurotrophic factor)
G: ndp (rattus norvegicus) (aka norrin cystine knot growth factor ndp)
H: ndn (homo sapiens) (aka necdin, mage family member)
I: ndpp (homo sapiens) (aka caspase recruitment domain family member 8)
J: None of the above. | [A; A] |
<Instruct>: Given the context 'A common polymorphic allele of the human luteinizing hormone beta-subunit gene: additional mutations and differential function of the promoter sequence.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [luteinizing hormone beta-subunit]
<Options>: A: luteinizing hormone subunit beta (bos taurus) (aka luteinizing hormone subunit beta)
B: luteinizing hormone subunit beta (homo sapiens) (aka luteinizing hormone subunit beta)
C: thyroid stimulating hormone subunit beta (homo sapiens) (aka thyroid stimulating hormone subunit beta)
D: lutropin subunit beta (bos taurus) (aka lutropin subunit beta)
E: follicle stimulating hormone subunit beta (homo sapiens) (aka follicle stimulating hormone subunit beta)
F: None of the above. | [B] |
<Instruct>: Given the context 'A common genetic variant (V) of the human luteinizing hormone (LH) beta-subunit gene was recently discovered.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [luteinizing hormone (lh) beta-subunit]
<Options>: A: follicle stimulating hormone subunit beta (homo sapiens) (aka follicle stimulating hormone subunit beta)
B: thyroid stimulating hormone subunit beta (homo sapiens) (aka thyroid stimulating hormone subunit beta)
C: luteinizing hormone subunit beta (homo sapiens) (aka luteinizing hormone subunit beta)
D: lhb (homo sapiens) (chorionic gonadotropin subunit beta 3 (homo sapiens)) (aka chorionic gonadotropin subunit beta 3)
E: luteinizing hormone subunit beta (bos taurus) (aka luteinizing hormone subunit beta)
F: None of the above. | [C] |
<Instruct>: Given the context 'The V-LH molecules have higher bioactivity in vitro, but shorter half-life in circulation, which apparently is related to the alterations of LH function observed in individuals homo- and heterozygous for the V-LHbeta allele.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lhbeta]
<Options>: A: lutropin subunit beta-like (xenopus tropicalis) (aka lutropin subunit beta-like)
B: luteinizing hormone subunit beta (xenopus tropicalis) (aka luteinizing hormone subunit beta)
C: lsh-beta (homo sapiens) (aka luteinizing hormone subunit beta)
D: lutropin subunit beta (bos taurus) (aka lutropin subunit beta)
E: luteinizing hormone subunit beta (bos taurus) (aka luteinizing hormone subunit beta)
F: None of the above. | [C] |
<Instruct>: Given the context 'We have now studied whether additional mutations in the V-LHbeta promoter sequence could contribute to the altered physiology of the LH variant molecules.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lhbeta]
<Options>: A: luteinizing hormone subunit beta (bos taurus) (aka luteinizing hormone subunit beta)
B: luteinizing hormone subunit beta (oryctolagus cuniculus) (aka luteinizing hormone subunit beta)
C: luteinizing hormone subunit beta (xenopus tropicalis) (aka luteinizing hormone subunit beta)
D: lutropin subunit beta-like (xenopus laevis) (aka lutropin subunit beta-like)
E: lsh-beta (homo sapiens) (aka luteinizing hormone subunit beta)
F: None of the above. | [E] |
<Instruct>: Given the context 'The 661 bp 5'-flanking region of the V-LHbeta gene, retrieved from human genomic DNA by PCR, contained eight single-nucleotide changes, as compared with the wild-type (wt) LHbeta promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lhbeta]
<Options>: A: lutropin subunit beta (bos taurus) (aka lutropin subunit beta)
B: lhb (homo sapiens) (luteinizing hormone subunit beta (homo sapiens)) (aka luteinizing hormone subunit beta)
C: lutropin subunit beta-like (xenopus tropicalis) (aka lutropin subunit beta-like)
D: luteinizing hormone subunit beta (sus scrofa) (aka luteinizing hormone subunit beta)
E: lutropin subunit beta-like (xenopus laevis) (aka lutropin subunit beta-like)
F: None of the above. | [B] |
<Instruct>: Given the context 'The 661 bp 5'-flanking region of the V-LHbeta gene, retrieved from human genomic DNA by PCR, contained eight single-nucleotide changes, as compared with the wild-type (wt) LHbeta promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lhbeta]
<Options>: A: lutropin subunit beta-like (xenopus tropicalis) (aka lutropin subunit beta-like)
B: luteinizing hormone subunit beta (sus scrofa) (aka luteinizing hormone subunit beta)
C: lutropin subunit beta (bos taurus) (aka lutropin subunit beta)
D: lutropin subunit beta-like (xenopus laevis) (aka lutropin subunit beta-like)
E: None of the above. | [E] |
<Instruct>: Given the context 'Reporter constructs with various lengths of the wt- and V-LH promoter sequences, driving the firefly luciferase reporter gene, were transfected into an immortalized mouse pituitary cell line, LbetaT(2), known to express the endogenous LHbeta gene, and into a non-endocrine human embryonic kidney cell line, HEK 293.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lhbeta]
<Options>: A: lutropin subunit beta-like (xenopus laevis) (aka lutropin subunit beta-like)
B: lutropin subunit beta-like (xenopus tropicalis) (aka lutropin subunit beta-like)
C: luteinizing hormone subunit beta (xenopus tropicalis) (aka luteinizing hormone subunit beta)
D: luteinizing hormone subunit beta (homo sapiens) (aka luteinizing hormone subunit beta)
E: luteinizing hormone subunit beta (bos taurus) (aka luteinizing hormone subunit beta)
F: None of the above. | [D] |
<Instruct>: Given the context 'Basal expression levels of the V-LHbeta promoter constructs were on average 36% higher in LbetaT(2)cells ( P < 0.001; n = 29), and 40% higher in HEK 293 cells ( P < 0.001; n = 16), as compared with the respective wt sequences.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lhbeta]
<Options>: A: luteinizing hormone subunit beta (oryctolagus cuniculus) (aka luteinizing hormone subunit beta)
B: luteinizing hormone subunit beta (homo sapiens) (aka luteinizing hormone subunit beta)
C: lutropin subunit beta-like (xenopus tropicalis) (aka lutropin subunit beta-like)
D: lutropin subunit beta (bos taurus) (aka lutropin subunit beta)
E: lutropin subunit beta-like (xenopus laevis) (aka lutropin subunit beta-like)
F: None of the above. | [B] |
<Instruct>: Given the context 'Numerous qualitative and quantitative differences were found between the two cell lines in responses of the two promoter sequences to stimulation with 12- O -tetradecanoylphorbol-13-acetate, forskolin, 8-bromo-cAMP, progesterone and gonado- tropin-releasing hormone.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gonado- tropin-releasing hormone]
<Options>: A: gonadotropin releasing hormone 1 (homo sapiens) (aka gonadotropin releasing hormone 1)
B: growth hormone releasing hormone (homo sapiens) (aka growth hormone releasing hormone)
C: hypocretin (orexin) neuropeptide precursor (xenopus tropicalis) (aka hypocretin (orexin) neuropeptide precursor)
D: growth hormone releasing hormone (xenopus tropicalis) (aka growth hormone releasing hormone)
E: gnrh (xenopus tropicalis) (aka gonadotropin releasing hormone 1)
F: None of the above. | [A] |
<Instruct>: Given the context 'In conclusion, the V-LHbeta promoter has higher basal activity, and differs in response to hormonal stimulation, as compared with the wt-LHbeta promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lhbeta]
<Options>: A: lutropin subunit beta-like (xenopus laevis) (aka lutropin subunit beta-like)
B: lutropin subunit beta (bos taurus) (aka lutropin subunit beta)
C: luteinizing hormone subunit beta (oryctolagus cuniculus) (aka luteinizing hormone subunit beta)
D: lhb (homo sapiens) (luteinizing hormone subunit beta (homo sapiens)) (aka luteinizing hormone subunit beta)
E: lutropin subunit beta-like (xenopus tropicalis) (aka lutropin subunit beta-like)
F: None of the above. | [D] |
<Instruct>: Given the context 'The altered promoter function of the V-LHbeta gene provides evidence for differences in regulation of the wt- and V-LHbeta genes, which may contribute to the differences observed in pituitary-gonadal function between carriers of the two LHbeta alleles.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lhbeta]
<Options>: A: lutropin subunit beta-like (xenopus tropicalis) (aka lutropin subunit beta-like)
B: lutropin subunit beta (bos taurus) (aka lutropin subunit beta)
C: lutropin subunit beta-like (xenopus laevis) (aka lutropin subunit beta-like)
D: luteinizing hormone subunit beta (xenopus tropicalis) (aka luteinizing hormone subunit beta)
E: luteinizing hormone subunit beta (homo sapiens) (aka luteinizing hormone subunit beta)
F: None of the above. | [E] |
<Instruct>: Given the context 'The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hydroxypyruvate reductase; grhpr]
<Options>: A: hydroxypyruvate reductase 3 (arabidopsis thaliana) (aka d-isomer specific 2-hydroxyacid dehydrogenase family protein)
B: glyoxylate reductase (escherichia coli str. k-12 substr. mg1655) (aka glyoxylate reductase)
C: glyoxylate and hydroxypyruvate reductase (rattus norvegicus) (aka glyoxylate and hydroxypyruvate reductase)
D: grpr (homo sapiens) (aka gastrin releasing peptide receptor)
E: hydroxypyruvate reductase (arabidopsis thaliana) (aka hydroxypyruvate reductase)
F: growth hormone releasing hormone receptor (homo sapiens) (aka growth hormone releasing hormone receptor)
G: glyoxylate and hydroxypyruvate reductase (homo sapiens) (aka glyoxylate and hydroxypyruvate reductase)
H: grr1 (glycine max) (aka putative ein3-binding f-box protein)
I: gonadotropin releasing hormone receptor (homo sapiens) (aka gonadotropin releasing hormone receptor)
J: None of the above. | [G; G] |
<Instruct>: Given the context 'The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hydroxypyruvate reductase; grhpr]
<Options>: A: gr (homo sapiens) (aka nuclear receptor subfamily 3 group c member 1)
B: glyoxylate/hydroxypyruvate reductase a (escherichia coli str. k-12 substr. mg1655) (aka glyoxylate/hydroxypyruvate reductase a)
C: glyoxylate and hydroxypyruvate reductase (homo sapiens) (aka glyoxylate and hydroxypyruvate reductase)
D: glyoxylate reductase (escherichia coli str. k-12 substr. mg1655) (aka glyoxylate reductase)
E: grr1 (glycine max) (aka putative ein3-binding f-box protein)
F: prolactin releasing hormone receptor (homo sapiens) (aka prolactin releasing hormone receptor)
G: glyoxylate and hydroxypyruvate reductase (rattus norvegicus) (aka glyoxylate and hydroxypyruvate reductase)
H: hdhpr (homo sapiens) (aka quinoid dihydropteridine reductase)
I: grhr (homo sapiens) (aka gonadotropin releasing hormone receptor)
J: None of the above. | [C; C] |
<Instruct>: Given the context 'We identified a glyoxylate reductase/hydroxypyruvate reductase (GRHPR) cDNA clone from a human liver expressed sequence tag (EST) library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [glyoxylate reductase; hydroxypyruvate reductase; grhpr]
<Options>: A: grr1 (glycine max) (aka putative ein3-binding f-box protein)
B: glyoxylate reductase 1 homolog (xenopus tropicalis) (aka glyoxylate reductase 1 homolog)
C: glyoxylate and hydroxypyruvate reductase (rattus norvegicus) (aka glyoxylate and hydroxypyruvate reductase)
D: reductase (glycine max) (aka chalcone reductase chr1)
E: glyoxylate/succinic semialdehyde reductase 1 (glycine max) (aka glyoxylate/succinic semialdehyde reductase 1)
F: hydroxypyruvate reductase (arabidopsis thaliana) (aka hydroxypyruvate reductase)
G: glyoxylate reductase 1 homolog (homo sapiens) (aka glyoxylate reductase 1 homolog)
H: glyoxylate and hydroxypyruvate reductase (bos taurus) (aka glyoxylate and hydroxypyruvate reductase)
I: growth hormone releasing hormone receptor (homo sapiens) (aka growth hormone releasing hormone receptor)
J: gr (homo sapiens) (aka nuclear receptor subfamily 3 group c member 1)
K: glyoxylate and hydroxypyruvate reductase (homo sapiens) (aka glyoxylate and hydroxypyruvate reductase)
L: glyoxylate reductase 1 homolog (rattus norvegicus) (aka glyoxylate reductase 1 homolog)
M: prolactin releasing hormone receptor (homo sapiens) (aka prolactin releasing hormone receptor)
N: None of the above. | [K; K; K] |
<Instruct>: Given the context 'We identified a glyoxylate reductase/hydroxypyruvate reductase (GRHPR) cDNA clone from a human liver expressed sequence tag (EST) library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [glyoxylate reductase; hydroxypyruvate reductase; grhpr]
<Options>: A: glyoxylate reductase 1 homolog (xenopus tropicalis) (aka glyoxylate reductase 1 homolog)
B: glyoxylate reductase 1 homolog (rattus norvegicus) (aka glyoxylate reductase 1 homolog)
C: hydroxypyruvate reductase 3 (arabidopsis thaliana) (aka d-isomer specific 2-hydroxyacid dehydrogenase family protein)
D: glyoxylate reductase 1 (arabidopsis thaliana) (aka glyoxylate reductase 1)
E: glyoxylate and hydroxypyruvate reductase (homo sapiens) (aka glyoxylate and hydroxypyruvate reductase)
F: prolactin releasing hormone receptor (homo sapiens) (aka prolactin releasing hormone receptor)
G: grr1 (glycine max) (aka putative ein3-binding f-box protein)
H: gr (homo sapiens) (aka nuclear receptor subfamily 3 group c member 1)
I: glyoxylate reductase (escherichia coli str. k-12 substr. mg1655) (aka glyoxylate reductase)
J: grhpr (xenopus tropicalis) (glyoxylate reductase/hydroxypyruvate reductase, gene 1 (xenopus tropicalis)) (aka glyoxylate reductase/hydroxypyruvate reductase, gene 1)
K: gonadotropin releasing hormone receptor (homo sapiens) (aka gonadotropin releasing hormone receptor)
L: glyoxylate/hydroxypyruvate reductase a (escherichia coli str. k-12 substr. mg1655) (aka glyoxylate/hydroxypyruvate reductase a)
M: hdhpr (homo sapiens) (aka quinoid dihydropteridine reductase)
N: None of the above. | [E; E; E] |
<Instruct>: Given the context 'We identified a glyoxylate reductase/hydroxypyruvate reductase (GRHPR) cDNA clone from a human liver expressed sequence tag (EST) library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [glyoxylate reductase; hydroxypyruvate reductase; grhpr]
<Options>: A: glyoxylate and hydroxypyruvate reductase (rattus norvegicus) (aka glyoxylate and hydroxypyruvate reductase)
B: glyoxylate reductase 1 homolog (bos taurus) (aka glyoxylate reductase 1 homolog)
C: gr (homo sapiens) (aka nuclear receptor subfamily 3 group c member 1)
D: glyoxylate reductase (escherichia coli str. k-12 substr. mg1655) (aka glyoxylate reductase)
E: grpr (homo sapiens) (aka gastrin releasing peptide receptor)
F: prolactin releasing hormone receptor (homo sapiens) (aka prolactin releasing hormone receptor)
G: glyoxylate reductase 1 homolog (rattus norvegicus) (aka glyoxylate reductase 1 homolog)
H: glyoxylate reductase 1 homolog (xenopus tropicalis) (aka glyoxylate reductase 1 homolog)
I: glyoxylate and hydroxypyruvate reductase (homo sapiens) (aka glyoxylate and hydroxypyruvate reductase)
J: hydroxypyruvate reductase (arabidopsis thaliana) (aka hydroxypyruvate reductase)
K: ghrhr (homo sapiens) (aka growth hormone releasing hormone receptor)
L: hdhpr (homo sapiens) (aka quinoid dihydropteridine reductase)
M: None of the above. | [I; I; I] |
<Instruct>: Given the context 'Transient transfection of the cDNA clone into COS cells verified that it encoded an enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [glyoxylate reductase]
<Options>: A: glyoxylate reductase 1 homolog (sus scrofa) (aka glyoxylate reductase 1 homolog)
B: glyoxylate reductase (escherichia coli str. k-12 substr. mg1655) (aka glyoxylate reductase)
C: glyoxylate and hydroxypyruvate reductase (homo sapiens) (aka glyoxylate and hydroxypyruvate reductase)
D: glyoxylate reductase 1 homolog (bos taurus) (aka glyoxylate reductase 1 homolog)
E: glyoxylate/succinic semialdehyde reductase 1 (glycine max) (aka glyoxylate/succinic semialdehyde reductase 1)
F: None of the above. | [C] |
<Instruct>: Given the context 'The genomic structure of the human GRHPR gene was determined and contains nine exons and eight introns and spans approximately 9 kb pericentromeric on chromosome 9.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [grhpr]
<Options>: A: grr1 (glycine max) (aka putative ein3-binding f-box protein)
B: prolactin releasing hormone receptor (homo sapiens) (aka prolactin releasing hormone receptor)
C: grhpr (homo sapiens) (aka glyoxylate and hydroxypyruvate reductase)
D: gr (homo sapiens) (aka nuclear receptor subfamily 3 group c member 1)
E: grpr (homo sapiens) (aka gastrin releasing peptide receptor)
F: None of the above. | [C] |
<Instruct>: Given the context 'The genomic structure of the human GRHPR gene was determined and contains nine exons and eight introns and spans approximately 9 kb pericentromeric on chromosome 9.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [grhpr]
<Options>: A: gr (homo sapiens) (aka nuclear receptor subfamily 3 group c member 1)
B: grr1 (glycine max) (aka putative ein3-binding f-box protein)
C: prolactin releasing hormone receptor (homo sapiens) (aka prolactin releasing hormone receptor)
D: grpr (homo sapiens) (aka gastrin releasing peptide receptor)
E: None of the above. | [E] |
<Instruct>: Given the context 'Four PH2 patients representing two pairs of siblings from two unrelated families were analyzed for mutations in GRHPR by single strand conformation polymorphism analysis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [grhpr]
<Options>: A: gr (homo sapiens) (aka nuclear receptor subfamily 3 group c member 1)
B: grhpr (homo sapiens) (aka glyoxylate and hydroxypyruvate reductase)
C: grpr (homo sapiens) (aka gastrin releasing peptide receptor)
D: gonadotropin releasing hormone receptor (homo sapiens) (aka gonadotropin releasing hormone receptor)
E: ghrfr (homo sapiens) (aka growth hormone releasing hormone receptor)
F: None of the above. | [B] |
<Instruct>: Given the context 'The cDNA that we have identified represents the first characterization of an animal GRHPR sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [grhpr]
<Options>: A: ghrfr (homo sapiens) (aka growth hormone releasing hormone receptor)
B: grhpr (homo sapiens) (aka glyoxylate and hydroxypyruvate reductase)
C: grpr (homo sapiens) (aka gastrin releasing peptide receptor)
D: gr (homo sapiens) (aka nuclear receptor subfamily 3 group c member 1)
E: grhr (homo sapiens) (aka gonadotropin releasing hormone receptor)
F: None of the above. | [B] |
<Instruct>: Given the context 'Ectodysplasin is a collagenous trimeric type II membrane protein with a tumor necrosis factor-like domain and co-localizes with cytoskeletal structures at lateral and apical surfaces of cells.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ectodysplasin]
<Options>: A: ectodysplasin a receptor (xenopus tropicalis) (aka ectodysplasin a receptor)
B: ectodysplasin a (danio rerio) (aka ectodysplasin a)
C: ectodysplasin a (xenopus tropicalis) (aka ectodysplasin a)
D: hed (homo sapiens) (ectodysplasin a (homo sapiens)) (aka ectodysplasin a)
E: ectodysplasin a (bos taurus) (aka ectodysplasin a)
F: None of the above. | [D] |
<Instruct>: Given the context 'Anhidrotic ectodermal dysplasia (EDA) is a human genetic disorder of impaired ectodermal appendage development.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ectodermal dysplasia; eda]
<Options>: A: otodental dysplasia chromosome deletion syndrome (homo sapiens) (aka otodental dysplasia chromosome deletion syndrome)
B: ectodysplasin a receptor (homo sapiens) (aka ectodysplasin a receptor)
C: edd (arabidopsis thaliana) (aka glycine-trna ligase)
D: asphixiating thoracic dystrophy (chondroectodermal dysplasia-like syndrome) (homo sapiens) (aka asphixiating thoracic dystrophy (chondroectodermal dysplasia-like syndrome))
E: ectodermal dysplasia 6, hair/nail type (homo sapiens) (aka ectodermal dysplasia 6, hair/nail type)
F: eda1 (xenopus laevis) (ectodysplasin a s homeolog (xenopus laevis)) (aka ectodysplasin a s homeolog)
G: endove syndrome, limb-only type (homo sapiens) (aka endove syndrome, limb-only type)
H: eda1 (arabidopsis thaliana) (aka f-box associated ubiquitination effector family protein)
I: embryonic ectoderm development (homo sapiens) (aka embryonic ectoderm development)
J: eda (homo sapiens) (aka ectodysplasin a)
K: None of the above. | [J; J] |
<Instruct>: Given the context 'Anhidrotic ectodermal dysplasia (EDA) is a human genetic disorder of impaired ectodermal appendage development.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ectodermal dysplasia; eda]
<Options>: A: asphixiating thoracic dystrophy (chondroectodermal dysplasia-like syndrome) (homo sapiens) (aka asphixiating thoracic dystrophy (chondroectodermal dysplasia-like syndrome))
B: otodental dysplasia chromosome deletion syndrome (homo sapiens) (aka otodental dysplasia chromosome deletion syndrome)
C: endove syndrome, limb-only type (homo sapiens) (aka endove syndrome, limb-only type)
D: eda1 (homo sapiens) (aka ectodysplasin a)
E: edd (arabidopsis thaliana) (aka glycine-trna ligase)
F: ectrodactyly, ectodermal dysplasia and cleft lip/palate syndrome 1 (homo sapiens) (aka ectrodactyly, ectodermal dysplasia and cleft lip/palate syndrome 1)
G: eda3 (homo sapiens) (ectodysplasin a receptor (homo sapiens)) (aka ectodysplasin a receptor)
H: ectodermal dysplasia 5, hair/nail type (homo sapiens) (aka ectodermal dysplasia 5, hair/nail type)
I: eda1 (xenopus laevis) (ectodysplasin a s homeolog (xenopus laevis)) (aka ectodysplasin a s homeolog)
J: eda1 (arabidopsis thaliana) (aka f-box associated ubiquitination effector family protein)
K: None of the above. | [D; D] |
<Instruct>: Given the context 'The EDA gene encodes isoforms of a novel transmembrane protein, ectodysplasin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eda; ectodysplasin]
<Options>: A: eda1 (xenopus laevis) (ectodysplasin a s homeolog (xenopus laevis)) (aka ectodysplasin a s homeolog)
B: ectodysplasin a receptor (homo sapiens) (aka ectodysplasin a receptor)
C: edd (arabidopsis thaliana) (aka glycine-trna ligase)
D: ectodysplasin a (danio rerio) (aka ectodysplasin a)
E: ectodysplasin a (xenopus tropicalis) (aka ectodysplasin a)
F: eda1 (homo sapiens) (aka ectodysplasin a)
G: ectodysplasin a receptor (xenopus tropicalis) (aka ectodysplasin a receptor)
H: eda1 (arabidopsis thaliana) (aka f-box associated ubiquitination effector family protein)
I: None of the above. | [F; F] |
<Instruct>: Given the context 'The EDA gene encodes isoforms of a novel transmembrane protein, ectodysplasin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eda; ectodysplasin]
<Options>: A: ectodysplasin a (homo sapiens) (aka ectodysplasin a)
B: eda1 (arabidopsis thaliana) (aka f-box associated ubiquitination effector family protein)
C: ed3 (homo sapiens) (ectodysplasin a receptor (homo sapiens)) (aka ectodysplasin a receptor)
D: ectodysplasin a (sus scrofa) (aka ectodysplasin a)
E: ectodysplasin a receptor (homo sapiens) (aka ectodysplasin a receptor)
F: edd (arabidopsis thaliana) (aka glycine-trna ligase)
G: ectodysplasin a receptor (xenopus tropicalis) (aka ectodysplasin a receptor)
H: ectodysplasin a (xenopus tropicalis) (aka ectodysplasin a)
I: eda1 (xenopus laevis) (ectodysplasin a s homeolog (xenopus laevis)) (aka ectodysplasin a s homeolog)
J: None of the above. | [A; A] |
<Instruct>: Given the context 'In order to understand better the function of the ectodysplasin protein molecule and its domains, we have studied the processing and localization of wild-type and mutated isoforms in transfected human fetal kidney 293 and monkey kidney COS-1 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ectodysplasin]
<Options>: A: ectodysplasin a (bos taurus) (aka ectodysplasin a)
B: ed3 (homo sapiens) (ectodysplasin a receptor (homo sapiens)) (aka ectodysplasin a receptor)
C: ectodysplasin a (danio rerio) (aka ectodysplasin a)
D: hed (homo sapiens) (ectodysplasin a (homo sapiens)) (aka ectodysplasin a)
E: ectodysplasin a receptor (xenopus tropicalis) (aka ectodysplasin a receptor)
F: None of the above. | [D] |
<Instruct>: Given the context 'Similar to other members of collagenous membrane proteins and members of TNF-related ligands, ectodysplasin is a type II membrane protein and it forms trimers.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ectodysplasin]
<Options>: A: ectd1 (homo sapiens) (ectodysplasin a (homo sapiens)) (aka ectodysplasin a)
B: ectodysplasin a (sus scrofa) (aka ectodysplasin a)
C: ectodysplasin a receptor (xenopus tropicalis) (aka ectodysplasin a receptor)
D: ectodysplasin a (xenopus tropicalis) (aka ectodysplasin a)
E: ectodysplasin a (bos taurus) (aka ectodysplasin a)
F: None of the above. | [A] |
<Instruct>: Given the context 'The membrane localization of ectodysplasin is asymmetrical: it is found on the apical and lateral surfaces of the cells where it co-localizes with cytoskeletal structures.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ectodysplasin]
<Options>: A: ectodysplasin a (sus scrofa) (aka ectodysplasin a)
B: ectodysplasin a (xenopus tropicalis) (aka ectodysplasin a)
C: ectodysplasin a (danio rerio) (aka ectodysplasin a)
D: ectodysplasin a receptor (xenopus tropicalis) (aka ectodysplasin a receptor)
E: ectd1 (homo sapiens) (ectodysplasin a (homo sapiens)) (aka ectodysplasin a)
F: None of the above. | [E] |
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