instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Here we show that Yaf2 also binds to the Myc protein in vivo and in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [yaf2; myc]
<Options>: A: myc proto-oncogene, bhlh transcription factor (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
B: yaf2-b (xenopus laevis) (yy1 associated factor 2 s homeolog (xenopus laevis)) (aka yy1 associated factor 2 s homeolog)
C: yaf5 (saccharomyces cerevisiae s288c) (aka u... | [J; A] |
<Instruct>: Given the context 'In contrast to the activating effect on MycN function, Yaf2 inhibits Myc mediated transactivation and transformation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mycn; yaf2; myc]
<Options>: A: yaf1 (homo sapiens) (aka histone deacetylase 2)
B: mycn proto-oncogene, bhlh transcription factor (xenopus tropicalis) (aka mycn proto-oncogene, bhlh transcription factor)
C: yaf2 (homo sapiens) (aka yy1 associated factor 2)
D: myc-like oncogene, s-myc protein (mus musculus) ... | [F; C; M] |
<Instruct>: Given the context 'In contrast to the activating effect on MycN function, Yaf2 inhibits Myc mediated transactivation and transformation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mycn; yaf2; myc]
<Options>: A: n-myc (homo sapiens) (aka mycn proto-oncogene, bhlh transcription factor)
B: yaf5 (saccharomyces cerevisiae s288c) (aka ubiquitin-protein transferase activating protein pex22)
C: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-... | [A; D; F] |
<Instruct>: Given the context 'In contrast to the activating effect on MycN function, Yaf2 inhibits Myc mediated transactivation and transformation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mycn; yaf2; myc]
<Options>: A: c-myc-binding protein homolog (glycine max) (aka c-myc-binding protein homolog)
B: myc-like oncogene, s-myc protein (mus musculus) (aka myc-like oncogene, s-myc protein)
C: mycl proto-oncogene, bhlh transcription factor (homo sapiens) (aka mycl proto-oncogene, bhlh transcript... | [G; K; D] |
<Instruct>: Given the context 'This differential influence on two members of the Myc family gives insight into a new mechanism to modulate the biological activities of Myc transcription factors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [myc]
<Options>: A: mycl (homo sapiens) (aka mycl proto-oncogene, bhlh transcription factor)
B: myc proto-oncogene, bhlh transcription factor (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
C: myc-like oncogene, s-myc protein (mus musculus) (aka myc-like oncogene, s-myc protein)
D: v-myc ... | [B] |
<Instruct>: Given the context 'This differential influence on two members of the Myc family gives insight into a new mechanism to modulate the biological activities of Myc transcription factors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [myc]
<Options>: A: myc-like oncogene, s-myc protein (mus musculus) (aka myc-like oncogene, s-myc protein)
B: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
C: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc ... | [E] |
<Instruct>: Given the context 'Bacteria expressing the kinase domain of the keratinocyte growth factor receptor (bek/fibroblast growth factor receptor 2) were infected with a fibroblast cDNA library in a phagemid prokaryotic expression vector and screened with a monoclonal anti-phosphotyrosine antibody.', select the co... | <Mentions>: [keratinocyte growth factor receptor; bek; fibroblast growth factor receptor 2]
<Options>: A: blk proto-oncogene, src family tyrosine kinase (bos taurus) (aka blk proto-oncogene, src family tyrosine kinase)
B: fibroblast growth factor receptor 3 (homo sapiens) (aka fibroblast growth factor receptor 3)
C: el... | [G; G; G] |
<Instruct>: Given the context 'Bacteria expressing the kinase domain of the keratinocyte growth factor receptor (bek/fibroblast growth factor receptor 2) were infected with a fibroblast cDNA library in a phagemid prokaryotic expression vector and screened with a monoclonal anti-phosphotyrosine antibody.', select the co... | <Mentions>: [keratinocyte growth factor receptor; bek; fibroblast growth factor receptor 2]
<Options>: A: blk (bos taurus) (aka blk proto-oncogene, src family tyrosine kinase)
B: fibroblast growth factor receptor 3 (homo sapiens) (aka fibroblast growth factor receptor 3)
C: kgfr (homo sapiens) (aka fibroblast growth fa... | [C; C; C] |
<Instruct>: Given the context 'Bacteria expressing the kinase domain of the keratinocyte growth factor receptor (bek/fibroblast growth factor receptor 2) were infected with a fibroblast cDNA library in a phagemid prokaryotic expression vector and screened with a monoclonal anti-phosphotyrosine antibody.', select the co... | <Mentions>: [keratinocyte growth factor receptor; bek; fibroblast growth factor receptor 2]
<Options>: A: bek (gallus gallus) (aka fibroblast growth factor receptor 2)
B: fgfr-1 (homo sapiens) (aka fibroblast growth factor receptor 1)
C: fibroblast growth factor receptor 3 (homo sapiens) (aka fibroblast growth factor r... | [J; J; J] |
<Instruct>: Given the context 'Both serine and tyrosine phosphatase activities were completely abolished by mutagenesis of a single cysteine residue conserved in VH1 and the VH1-related (VHR) human protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [vh1-related (vhr) human protein]
<Options>: A: vh5 (homo sapiens) (aka immunoglobulin heavy variable 5-78 (pseudogene))
B: vhp (homo sapiens) (aka dual specificity phosphatase 28)
C: vhr (homo sapiens) (aka dual specificity phosphatase 3)
D: vh3 (homo sapiens) (aka immunoglobulin heavy variable 3-75 (pseud... | [C] |
<Instruct>: Given the context 'Both serine and tyrosine phosphatase activities were completely abolished by mutagenesis of a single cysteine residue conserved in VH1 and the VH1-related (VHR) human protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [vh1-related (vhr) human protein]
<Options>: A: vhx (homo sapiens) (aka dual specificity phosphatase 22)
B: vh5 (homo sapiens) (aka immunoglobulin heavy variable 5-78 (pseudogene))
C: vh3 (homo sapiens) (aka immunoglobulin heavy variable 3-75 (pseudogene))
D: vhp (homo sapiens) (aka dual specificity phospha... | [E] |
<Instruct>: Given the context 'These properties suggest that VHR is capable of regulating intracellular events mediated by both tyrosine and serine phosphorylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [vhr]
<Options>: A: vho (homo sapiens) (aka growth differentiation factor 11)
B: vhr2 (saccharomyces cerevisiae s288c) (aka vhr2p)
C: vh5 (homo sapiens) (aka immunoglobulin heavy variable 5-78 (pseudogene))
D: vhr (homo sapiens) (aka dual specificity phosphatase 3)
E: ig heavy chain v region 102-like (rattu... | [D] |
<Instruct>: Given the context 'Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [ah receptor nuclear translocator; arnt; ah receptor]
<Options>: A: aryl hydrocarbon receptor nuclear translocator (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator)
B: arno (homo sapiens) (aka cytohesin 2)
C: ahr (homo sapiens) (aka aryl hydrocarbon receptor)
D: aryl hydrocarbon receptor r... | [A; A; C] |
<Instruct>: Given the context 'Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [ah receptor nuclear translocator; arnt; ah receptor]
<Options>: A: arnt (mus musculus) (aka aryl hydrocarbon receptor nuclear translocator)
B: aryl hydrocarbon receptor nuclear translocator (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator)
C: ahr (homo sapiens) (aka aryl hydrocarbon recep... | [N; N; C] |
<Instruct>: Given the context 'Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [ah receptor nuclear translocator; arnt; ah receptor]
<Options>: A: ahrr (homo sapiens) (cytochrome p450 family 1 subfamily a member 1 (homo sapiens)) (aka cytochrome p450 family 1 subfamily a member 1)
B: arnt (mus musculus) (aka aryl hydrocarbon receptor nuclear translocator)
C: arno3 (homo sapiens) (aka ... | [I; I; E] |
<Instruct>: Given the context 'Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [ah receptor nuclear translocator; arnt; ah receptor]
<Options>: A: arnt2 (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator 2)
B: arnt (drosophila melanogaster) (aka tango)
C: aryl hydrocarbon receptor (bos taurus) (aka aryl hydrocarbon receptor)
D: aryl hydrocarbon receptor nuclear translo... | [M; M; E] |
<Instruct>: Given the context 'The Ah (dioxin) receptor binds a number of widely disseminated environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polycyclic aromatic hydrocarbons, and mediates their carcinogenic effects.', select the correct biomedical concept for each mention using the p... | <Mentions>: [ah (dioxin) receptor]
<Options>: A: aryl hydrocarbon receptor nuclear translocator (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator)
B: aryl hydrocarbon receptor nuclear translocator homolog (caenorhabditis elegans) (aka aryl hydrocarbon receptor nuclear translocator homolog)
C: aryl hydr... | [D] |
<Instruct>: Given the context 'The ligand-bound receptor activates Cyp 1a1 gene transcription through interaction with specific DNA sequences, termed xenobiotic responsive elements (XREs).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one fo... | <Mentions>: [cyp 1a1]
<Options>: A: cytochrome p450 family 1 subfamily a member 1 (homo sapiens) (aka cytochrome p450 family 1 subfamily a member 1)
B: cyp1alpha (homo sapiens) (aka cytochrome p450 family 27 subfamily b member 1)
C: 1a1 (homo sapiens) (aka solute carrier family 45 member 2)
D: cytochrome p450 family 1 ... | [A] |
<Instruct>: Given the context 'The Ah receptor nuclear translocator protein (Arnt) is required for Ah receptor function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ah receptor nuclear translocator; arnt; ah receptor]
<Options>: A: ahrr (homo sapiens) (cytochrome p450 family 1 subfamily a member 1 (homo sapiens)) (aka cytochrome p450 family 1 subfamily a member 1)
B: aryl hydrocarbon receptor (rattus norvegicus) (aka aryl hydrocarbon receptor)
C: aryl hydrocarbon rece... | [H; H; K] |
<Instruct>: Given the context 'The Ah receptor nuclear translocator protein (Arnt) is required for Ah receptor function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ah receptor nuclear translocator; arnt; ah receptor]
<Options>: A: aryl hydrocarbon receptor nuclear translocator 2 (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator 2)
B: arnt (drosophila melanogaster) (aka tango)
C: ahrr (homo sapiens) (cytochrome p450 family 1 subfamily a member 1 (homo... | [I; I; L] |
<Instruct>: Given the context 'The Ah receptor nuclear translocator protein (Arnt) is required for Ah receptor function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ah receptor nuclear translocator; arnt; ah receptor]
<Options>: A: basic helix-loop-helix arnt like 1 (homo sapiens) (aka basic helix-loop-helix arnt like 1)
B: aryl hydrocarbon receptor nuclear translocator (xenopus tropicalis) (aka aryl hydrocarbon receptor nuclear translocator)
C: arnt1 (homo sapiens) (... | [C; C; J] |
<Instruct>: Given the context 'Arnt is now shown to be a structural component of the XRE binding form of the Ah receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [arnt; ah receptor]
<Options>: A: arno (homo sapiens) (aka cytohesin 2)
B: arnt (homo sapiens) (aryl hydrocarbon receptor nuclear translocator (homo sapiens)) (aka aryl hydrocarbon receptor nuclear translocator)
C: ahrr (homo sapiens) (cytochrome p450 family 1 subfamily a member 1 (homo sapiens)) (aka cytoc... | [B; H] |
<Instruct>: Given the context 'Arnt is now shown to be a structural component of the XRE binding form of the Ah receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [arnt; ah receptor]
<Options>: A: arnt1 (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator)
B: aryl hydrocarbon receptor nuclear translocator (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator)
C: arnt (drosophila melanogaster) (aka tango)
D: ahr (homo sapiens) (aka aryl hydr... | [A; D] |
<Instruct>: Given the context 'Furthermore, Arnt and the ligand-binding subunit of the receptor were extracted as a complex from the nuclei of cells treated with ligand.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [arnt]
<Options>: A: arnt (mus musculus) (aka aryl hydrocarbon receptor nuclear translocator)
B: arno (homo sapiens) (aka cytohesin 2)
C: arno3 (homo sapiens) (aka cytohesin 3)
D: arnt (drosophila melanogaster) (aka tango)
E: arnt1 (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator)
F: None ... | [E] |
<Instruct>: Given the context 'Arnt contains a basic helix-loop-helix motif, which may be responsible for interacting with both the XRE and the ligand-binding subunit.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [arnt]
<Options>: A: arnt (mus musculus) (aka aryl hydrocarbon receptor nuclear translocator)
B: arno (homo sapiens) (aka cytohesin 2)
C: arnt (drosophila melanogaster) (aka tango)
D: arno3 (homo sapiens) (aka cytohesin 3)
E: arnt (homo sapiens) (aryl hydrocarbon receptor nuclear translocator (homo sapiens)... | [E] |
<Instruct>: Given the context 'Characterization of SAF-A, a novel nuclear DNA binding protein from HeLa cells with high affinity for nuclear matrix/scaffold attachment DNA elements.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each... | <Mentions>: [saf-a]
<Options>: A: saf-a (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u)
B: saf-1 (homo sapiens) (aka myc associated zinc finger protein)
C: saf-b (homo sapiens) (aka scaffold attachment factor b)
D: saf-a (drosophila melanogaster) (aka uncharacterized protein)
E: saf1 (saccharomyces cerev... | [A] |
<Instruct>: Given the context 'We identified four proteins in nuclear extracts from HeLa cells which specifically bind to a scaffold attachment region (SAR) element from the human genome.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [scaffold attachment region; sar]
<Options>: A: small regulatory polypeptide of amino acid response (homo sapiens) (aka small regulatory polypeptide of amino acid response)
B: saraf (homo sapiens) (aka store-operated calcium entry associated regulatory factor)
C: serine/threonine kinase receptor associated ... | [J; J] |
<Instruct>: Given the context 'We identified four proteins in nuclear extracts from HeLa cells which specifically bind to a scaffold attachment region (SAR) element from the human genome.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [scaffold attachment region; sar]
<Options>: A: sra (drosophila melanogaster) (sarah (drosophila melanogaster)) (aka sarah)
B: clk4 associating serine/arginine rich protein (sus scrofa) (aka clk4 associating serine/arginine rich protein)
C: sara1 (homo sapiens) (aka secretion associated ras related gtpase 1... | [K; K] |
<Instruct>: Given the context 'Of these four proteins, SAF-A (scaffold attachment factor A), shows the highest affinity for several homologous and heterologous SAR elements from vertebrate cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options,... | <Mentions>: [saf-a; scaffold attachment factor a; sar]
<Options>: A: sar1a (homo sapiens) (aka secretion associated ras related gtpase 1a)
B: saf-a (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u)
C: saf-1 (homo sapiens) (aka myc associated zinc finger protein)
D: saf1 (saccharomyces cerevisiae s288c) (ak... | [B; B; N] |
<Instruct>: Given the context 'Of these four proteins, SAF-A (scaffold attachment factor A), shows the highest affinity for several homologous and heterologous SAR elements from vertebrate cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options,... | <Mentions>: [saf-a; scaffold attachment factor a; sar]
<Options>: A: sar1 (arabidopsis thaliana) (suppressor of auxin resistance1 (arabidopsis thaliana)) (aka suppressor of auxin resistance1)
B: saf-a (xenopus tropicalis) (aka heterogeneous nuclear ribonucleoprotein u (scaffold attachment factor a))
C: saf1 (saccharomy... | [I; I; O] |
<Instruct>: Given the context 'Of these four proteins, SAF-A (scaffold attachment factor A), shows the highest affinity for several homologous and heterologous SAR elements from vertebrate cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options,... | <Mentions>: [saf-a; scaffold attachment factor a; sar]
<Options>: A: saf-a (drosophila melanogaster) (aka uncharacterized protein)
B: uv stimulated scaffold protein a (sus scrofa) (aka uv stimulated scaffold protein a)
C: uv stimulated scaffold protein a (xenopus tropicalis) (aka uv stimulated scaffold protein a)
D: sa... | [M; M; O] |
<Instruct>: Given the context 'SAF-A is an abundant nuclear protein and a constituent of the nuclear matrix and scaffold.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [saf-a]
<Options>: A: saf-a2 (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u like 2)
B: saf-a (drosophila melanogaster) (aka uncharacterized protein)
C: saf-1 (homo sapiens) (aka myc associated zinc finger protein)
D: safa (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u)
E: saf-a... | [D] |
<Instruct>: Given the context 'SAF-A binds at multiple sites to the human SAR element; competition studies with synthetic polynucleotides indicate that these sites most probably reside in the multitude of A/T-stretches which are distributed throughout this element.', select the correct biomedical concept for each menti... | <Mentions>: [saf-a; sar]
<Options>: A: sar1 (arabidopsis thaliana) (suppressor of auxin resistance1 (arabidopsis thaliana)) (aka suppressor of auxin resistance1)
B: small regulatory polypeptide of amino acid response (sus scrofa) (aka small regulatory polypeptide of amino acid response)
C: saf-a (drosophila melanogaste... | [E; K] |
<Instruct>: Given the context 'SAF-A binds at multiple sites to the human SAR element; competition studies with synthetic polynucleotides indicate that these sites most probably reside in the multitude of A/T-stretches which are distributed throughout this element.', select the correct biomedical concept for each menti... | <Mentions>: [saf-a; sar]
<Options>: A: saf-a (xenopus tropicalis) (aka heterogeneous nuclear ribonucleoprotein u (scaffold attachment factor a))
B: sra (drosophila melanogaster) (sarah (drosophila melanogaster)) (aka sarah)
C: saf-b (homo sapiens) (aka scaffold attachment factor b)
D: saf (homo sapiens) (aka fas antise... | [I; K] |
<Instruct>: Given the context 'Expression cloning of a cDNA encoding UDP-GlcNAc:Gal beta 1-3-GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase by gene transfer into CHO cells expressing polyoma large tumor antigen.
', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [udp-glcnac:gal beta 1-3-galnac-r (glcnac to galnac) beta 1-6glcnac transferase]
<Options>: A: galnt6 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 6)
B: c2gnt-l (homo sapiens) (aka glucosaminyl (n-acetyl) transferase 1)
C: galnact (homo sapiens) (aka beta-1,4-n-acetyl-galactosaminyltran... | [B] |
<Instruct>: Given the context 'A cDNA encoding UDP-GlcNAc:Gal beta 1-3GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase (EC 2.4.1.102), which forms critical branches in O-glycans, has been isolated by an expression cloning approach using Chinese hamster ovary (CHO) cells.', select the correct biomedical concept fo... | <Mentions>: [udp-glcnac:gal beta 1-3galnac-r (glcnac to galnac) beta 1-6glcnac transferase]
<Options>: A: galnt1 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 1)
B: galnact6 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 6)
C: c2glcnact (homo sapiens) (aka glucosaminyl (n-acetyl) ... | [C] |
<Instruct>: Given the context 'Because the antibody used was found to detect most efficiently the oligosaccharide products attached to leukosialin, the CHO cells were also stably transfected with leukosialin cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [leukosialin]
<Options>: A: sialophorin (homo sapiens) (aka sialophorin)
B: leukosialin-like (rattus norvegicus) (aka leukosialin-like)
C: sialophorin (bos taurus) (aka sialophorin)
D: sialin (homo sapiens) (aka solute carrier family 17 member 5)
E: granulysin (homo sapiens) (aka granulysin)
F: None of the ... | [A] |
<Instruct>: Given the context 'The expression of the presumed catalytic domain as a fusion protein with the IgG binding domain of protein A enabled us to demonstrate unequivocally that the cDNA encodes the core 2 beta-1,6-N-acetylglucosaminyltransferase, the enzyme responsible for the formation of Gal beta 1-3(GlcNAc b... | <Mentions>: [core 2 beta-1,6-n-acetylglucosaminyltransferase]
<Options>: A: b3gnt1, beta-1,3-n-acetylgucosaminyltransferase 1, homolog;glyco_trans_2-like domain-containing protein (caenorhabditis elegans) (aka b3gnt1, beta-1,3-n-acetylgucosaminyltransferase 1, homolog;glyco_trans_2-like domain-containing protein)
B: c2... | [C] |
<Instruct>: Given the context 'The expression of the presumed catalytic domain as a fusion protein with the IgG binding domain of protein A enabled us to demonstrate unequivocally that the cDNA encodes the core 2 beta-1,6-N-acetylglucosaminyltransferase, the enzyme responsible for the formation of Gal beta 1-3(GlcNAc b... | <Mentions>: [core 2 beta-1,6-n-acetylglucosaminyltransferase]
<Options>: A: b3gnt1, beta-1,3-n-acetylgucosaminyltransferase 1, homolog (caenorhabditis elegans) (cele_c54c8.2 (caenorhabditis elegans)) (aka b3gnt1, beta-1,3-n-acetylgucosaminyltransferase 1, homolog)
B: c2gnt2 (homo sapiens) (aka glucosaminyl (n-acetyl) t... | [E] |
<Instruct>: Given the context 'Cloning of a novel tumor necrosis factor-alpha-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro.
TNF is a proinflammatory cytokine that has pleiotropic effects on cells and tissues, mediated in large part by alterat... | <Mentions>: [tumor necrosis factor-alpha; tnf]
<Options>: A: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
B: tumor necrosis factor (xenopus tropicalis) (aka tumor necrosis factor)
C: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
D: tumor necrosis factor (oryctolagus cuniculus) (aka tumor nec... | [E; E] |
<Instruct>: Given the context 'Cloning of a novel tumor necrosis factor-alpha-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro.
TNF is a proinflammatory cytokine that has pleiotropic effects on cells and tissues, mediated in large part by alterat... | <Mentions>: [tumor necrosis factor-alpha; tnf]
<Options>: A: tumor necrosis factor (homo sapiens) (aka tumor necrosis factor)
B: lymphotoxin alpha (homo sapiens) (aka lymphotoxin alpha)
C: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
D: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
... | [A; A] |
<Instruct>: Given the context 'We have used the technique of differential hybridization to identify several primary response genes induced by TNF in human umbilical vein endothelial (HUVE) cells, a cell type that is profoundly activated by cytokine treatment.', select the correct biomedical concept for each mention usi... | <Mentions>: [tnf]
<Options>: A: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
B: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
C: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
D: tnfb (homo sapiens) (aka lymphotoxin alpha)
E: tnfa (homo sapiens) (aka tumor ne... | [E] |
<Instruct>: Given the context 'One of these cDNA, designated B94, detects a rapidly and transiently induced 4-kb transcript in TNF-treated HUVE cells, and this transcript is superinduced in the concomitant presence of cycloheximide.', select the correct biomedical concept for each mention using the provided options. An... | <Mentions>: [b94; tnf]
<Options>: A: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
B: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
C: gpr94 (homo sapiens) (aka purinergic receptor p2y13)
D: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
E: natural killer cell... | [J; F] |
<Instruct>: Given the context 'One of these cDNA, designated B94, detects a rapidly and transiently induced 4-kb transcript in TNF-treated HUVE cells, and this transcript is superinduced in the concomitant presence of cycloheximide.', select the correct biomedical concept for each mention using the provided options. An... | <Mentions>: [b94; tnf]
<Options>: A: tnf (homo sapiens) (aka tumor necrosis factor)
B: ly94 (homo sapiens) (aka natural cytotoxicity triggering receptor 1)
C: b94 (homo sapiens) (aka tnf alpha induced protein 2)
D: rp94 (homo sapiens) (aka spermatogenesis associated 7)
E: natural killer cells antigen cd94 (bos taurus) ... | [C; A] |
<Instruct>: Given the context 'Other proinflammatory stimuli including IL-1 beta and LPS are also able to induce B94 mRNA expression.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-1 beta; b94]
<Options>: A: ly94 (homo sapiens) (aka natural cytotoxicity triggering receptor 1)
B: b94 (homo sapiens) (aka tnf alpha induced protein 2)
C: gpr94 (homo sapiens) (aka purinergic receptor p2y13)
D: b94 (mus musculus) (aka tumor necrosis factor, alpha-induced protein 2)
E: interleukin 1 beta... | [E; B] |
<Instruct>: Given the context 'Other proinflammatory stimuli including IL-1 beta and LPS are also able to induce B94 mRNA expression.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-1 beta; b94]
<Options>: A: interleukin 36 beta (homo sapiens) (aka interleukin 36 beta)
B: b94 (mus musculus) (aka tumor necrosis factor, alpha-induced protein 2)
C: natural killer cells antigen cd94 (bos taurus) (aka natural killer cells antigen cd94)
D: gpr94 (homo sapiens) (aka purinergic receptor p2... | [H; E] |
<Instruct>: Given the context 'Nuclear run-on experiments demonstrate that TNF induction of B94 transcript occurs primarily at the level of transcriptional activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [tnf; b94]
<Options>: A: b94 (homo sapiens) (aka tnf alpha induced protein 2)
B: natural killer cells antigen cd94 (bos taurus) (aka natural killer cells antigen cd94)
C: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
D: ly94 (homo sapiens) (aka natural cytotoxicity triggering recept... | [G; A] |
<Instruct>: Given the context 'Nuclear run-on experiments demonstrate that TNF induction of B94 transcript occurs primarily at the level of transcriptional activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [tnf; b94]
<Options>: A: tnf (homo sapiens) (aka tumor necrosis factor)
B: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
C: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
D: p94 (homo sapiens) (aka calpain 3)
E: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily m... | [A; F] |
<Instruct>: Given the context 'Further, B94 is shown to be a single copy gene that is evolutionarily conserved.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [b94]
<Options>: A: b94 (homo sapiens) (aka tnf alpha induced protein 2)
B: b94 (mus musculus) (aka tumor necrosis factor, alpha-induced protein 2)
C: p94 (homo sapiens) (aka calpain 3)
D: ly94 (homo sapiens) (aka natural cytotoxicity triggering receptor 1)
E: hg94 (homo sapiens) (aka olfactory receptor fam... | [A] |
<Instruct>: Given the context 'Developmental regulation occurs most prominently in mouse embryonic liver and kidney, and a second smaller form of B94 transcript is detected in the placenta and testes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [b94]
<Options>: A: hg94 (homo sapiens) (aka olfactory receptor family 7 subfamily e member 2 pseudogene)
B: p94 (homo sapiens) (aka calpain 3)
C: natural killer cells antigen cd94 (bos taurus) (aka natural killer cells antigen cd94)
D: b94 (homo sapiens) (aka tnf alpha induced protein 2)
E: ly94 (homo sapi... | [D] |
<Instruct>: Given the context 'B94 and other TNF-responsive transcripts are also induced during capillary tube formation suggesting overlap between genes induced by TNF and those induced during angiogenesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [b94; tnf]
<Options>: A: ly94 (homo sapiens) (aka natural cytotoxicity triggering receptor 1)
B: b94 (homo sapiens) (aka tnf alpha induced protein 2)
C: tnfc (homo sapiens) (aka lymphotoxin beta)
D: b94 (mus musculus) (aka tumor necrosis factor, alpha-induced protein 2)
E: tnf superfamily member 10 (homo sa... | [B; I] |
<Instruct>: Given the context 'B94 and other TNF-responsive transcripts are also induced during capillary tube formation suggesting overlap between genes induced by TNF and those induced during angiogenesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [b94; tnf]
<Options>: A: cp94 (homo sapiens) (aka beaded filament structural protein 1)
B: tnf (homo sapiens) (aka tumor necrosis factor)
C: tnfc (homo sapiens) (aka lymphotoxin beta)
D: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
E: gpr94 (homo sapiens) (aka purinergic receptor p... | [G; B] |
<Instruct>: Given the context 'Sequence analysis of the B94 cDNA reveals an open reading frame encoding a 73-kDa polypeptide that has no homology to any known protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [b94]
<Options>: A: gpr94 (homo sapiens) (aka purinergic receptor p2y13)
B: cp94 (homo sapiens) (aka beaded filament structural protein 1)
C: p94 (homo sapiens) (aka calpain 3)
D: b94 (mus musculus) (aka tumor necrosis factor, alpha-induced protein 2)
E: b94 (homo sapiens) (aka tnf alpha induced protein 2)
... | [E] |
<Instruct>: Given the context 'Polyclonal antisera directed against the carboxyl-terminal portion of the B94 protein immunoprecipitates a protein of the predicted molecular mass both from COS cells transfected with a B94 expression vector and from TNF-treated HUVE cells.', select the correct biomedical concept for each... | <Mentions>: [b94; tnf]
<Options>: A: natural killer cells antigen cd94 (bos taurus) (aka natural killer cells antigen cd94)
B: ly94 (homo sapiens) (aka natural cytotoxicity triggering receptor 1)
C: tumor necrosis factor (homo sapiens) (aka tumor necrosis factor)
D: tnf superfamily member 10 (homo sapiens) (aka tnf sup... | [E; C] |
<Instruct>: Given the context 'Polyclonal antisera directed against the carboxyl-terminal portion of the B94 protein immunoprecipitates a protein of the predicted molecular mass both from COS cells transfected with a B94 expression vector and from TNF-treated HUVE cells.', select the correct biomedical concept for each... | <Mentions>: [b94; tnf]
<Options>: A: tnfa (homo sapiens) (aka tumor necrosis factor)
B: cp94 (homo sapiens) (aka beaded filament structural protein 1)
C: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
D: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
E: cd294 (homo sapiens) (aka prosta... | [J; A] |
<Instruct>: Given the context 'A approximately 35-kDa polypeptide with a unique NH2-terminal sequence has been isolated from bovine lung and found to be present on the surface of endothelial cells where it mediates the binding of AGEs (receptor for advanced glycosylation end product or RAGE).', select the correct biome... | <Mentions>: [rage]
<Options>: A: rage-1 (homo sapiens) (aka mok protein kinase)
B: rage (homo sapiens) (advanced glycosylation end-product specific receptor (homo sapiens)) (aka advanced glycosylation end-product specific receptor)
C: ragef (homo sapiens) (aka rap guanine nucleotide exchange factor 2)
D: en-rage (bos t... | [B] |
<Instruct>: Given the context 'Using an oligonucleotide probe based on the amino-terminal sequence of RAGE, an apparently full-length cDNA of 1.5 kilobases was isolated from a bovine lung cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [rage]
<Options>: A: rage (homo sapiens) (advanced glycosylation end-product specific receptor (homo sapiens)) (aka advanced glycosylation end-product specific receptor)
B: rage (xenopus laevis) (aka mok protein kinase l homeolog)
C: rage (rattus norvegicus) (advanced glycosylation end product-specific rece... | [A] |
<Instruct>: Given the context 'Using an oligonucleotide probe based on the amino-terminal sequence of RAGE, an apparently full-length cDNA of 1.5 kilobases was isolated from a bovine lung cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [rage]
<Options>: A: rage (xenopus laevis) (aka mok protein kinase l homeolog)
B: rage (gallus gallus) (aka mok protein kinase)
C: ragef (homo sapiens) (aka rap guanine nucleotide exchange factor 2)
D: rage (rattus norvegicus) (advanced glycosylation end product-specific receptor (rattus norvegicus)) (aka a... | [E] |
<Instruct>: Given the context 'A partial clone encoding the human counterpart of RAGE, isolated from a human lung library, was found to be approximately 90% homologous to the bovine molecule.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one... | <Mentions>: [rage]
<Options>: A: rage (homo sapiens) (advanced glycosylation end-product specific receptor (homo sapiens)) (aka advanced glycosylation end-product specific receptor)
B: rage (gallus gallus) (aka mok protein kinase)
C: en-rage (bos taurus) (aka s100 calcium binding protein a12)
D: rage (bos taurus) (adva... | [A] |
<Instruct>: Given the context 'Based on computer analysis of the amino acid sequence of RAGE and comparison with databases, RAGE is a new member of the immunoglobulin superfamily of cell surface molecules and shares significant homology with MUC 18, NCAM, and the cytoplasmic domain of CD20.', select the correct biomedi... | <Mentions>: [rage; muc 18; ncam]
<Options>: A: ragef (homo sapiens) (aka rap guanine nucleotide exchange factor 2)
B: k18 (homo sapiens) (aka keratin 18)
C: rage (rattus norvegicus) (advanced glycosylation end product-specific receptor (rattus norvegicus)) (aka advanced glycosylation end product-specific receptor)
D: n... | [L; J; O] |
<Instruct>: Given the context 'Based on computer analysis of the amino acid sequence of RAGE and comparison with databases, RAGE is a new member of the immunoglobulin superfamily of cell surface molecules and shares significant homology with MUC 18, NCAM, and the cytoplasmic domain of CD20.', select the correct biomedi... | <Mentions>: [rage; muc 18; ncam]
<Options>: A: ncam (homo sapiens) (aka neural cell adhesion molecule 1)
B: rage1 (homo sapiens) (aka mok protein kinase)
C: ck-18 (homo sapiens) (aka keratin 18)
D: muc16 (homo sapiens) (aka mucin 16, cell surface associated)
E: major urinary protein 18 (mus musculus) (aka major urinary... | [I; F; A] |
<Instruct>: Given the context 'Based on computer analysis of the amino acid sequence of RAGE and comparison with databases, RAGE is a new member of the immunoglobulin superfamily of cell surface molecules and shares significant homology with MUC 18, NCAM, and the cytoplasmic domain of CD20.', select the correct biomedi... | <Mentions>: [rage; muc 18; ncam]
<Options>: A: cea cell adhesion molecule 18 (homo sapiens) (aka cea cell adhesion molecule 18)
B: rage (bos taurus) (advanced glycosylation end-product specific receptor (bos taurus)) (aka advanced glycosylation end-product specific receptor)
C: rage-1 (xenopus tropicalis) (aka mok prot... | [D; N; L] |
<Instruct>: Given the context 'Based on computer analysis of the amino acid sequence of RAGE and comparison with databases, RAGE is a new member of the immunoglobulin superfamily of cell surface molecules and shares significant homology with MUC 18, NCAM, and the cytoplasmic domain of CD20.', select the correct biomedi... | <Mentions>: [rage; muc 18; ncam]
<Options>: A: rage (gallus gallus) (aka mok protein kinase)
B: ncam-1 (mus musculus) (aka neural cell adhesion molecule 1)
C: muc18 (homo sapiens) (aka melanoma cell adhesion molecule)
D: rage (homo sapiens) (advanced glycosylation end-product specific receptor (homo sapiens)) (aka adva... | [D; C; O] |
<Instruct>: Given the context 'Based on computer analysis of the amino acid sequence of RAGE and comparison with databases, RAGE is a new member of the immunoglobulin superfamily of cell surface molecules and shares significant homology with MUC 18, NCAM, and the cytoplasmic domain of CD20.', select the correct biomedi... | <Mentions>: [cd20]
<Options>: A: cd20l (homo sapiens) (aka membrane spanning 4-domains a3)
B: cd20 (mus musculus) (aka membrane-spanning 4-domains, subfamily a, member 1)
C: cd20l1 (homo sapiens) (aka membrane spanning 4-domains a4a)
D: cd20l5 (homo sapiens) (aka membrane spanning 4-domains a8)
E: cd20 (homo sapiens) (... | [E] |
<Instruct>: Given the context 'Expression of the RAGE cDNA in 293 cells allowed them to bind 125I-AGE-albumin in a saturable and dose-dependent manner (Kd approximately 100 nM), blocked by antibody to RAGE.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [rage]
<Options>: A: ragef (homo sapiens) (aka rap guanine nucleotide exchange factor 2)
B: rage (xenopus laevis) (aka mok protein kinase l homeolog)
C: rage (bos taurus) (advanced glycosylation end-product specific receptor (bos taurus)) (aka advanced glycosylation end-product specific receptor)
D: rage (h... | [D] |
<Instruct>: Given the context 'Western blots of 293 cells transfected with RAGE cDNA probed with anti-RAGE IgG demonstrated expression of immunoreactive protein compared to its absence in mock-transfected cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [rage]
<Options>: A: rage (bos taurus) (advanced glycosylation end-product specific receptor (bos taurus)) (aka advanced glycosylation end-product specific receptor)
B: rage (homo sapiens) (advanced glycosylation end-product specific receptor (homo sapiens)) (aka advanced glycosylation end-product specific ... | [B] |
<Instruct>: Given the context 'These results suggest that RAGE functions as a cell surface receptor for AGEs, which could potentially mediate cellular effects of this class of glycosylated proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [rage]
<Options>: A: rage (bos taurus) (advanced glycosylation end-product specific receptor (bos taurus)) (aka advanced glycosylation end-product specific receptor)
B: rage (homo sapiens) (advanced glycosylation end-product specific receptor (homo sapiens)) (aka advanced glycosylation end-product specific ... | [B] |
<Instruct>: Given the context 'Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd59; ly-6]
<Options>: A: cd59 molecule (cd59 blood group) (homo sapiens) (aka cd59 molecule (cd59 blood group))
B: cd58 (homo sapiens) (aka cd58 molecule)
C: lymphocyte antigen 6 family member s (homo sapiens) (aka lymphocyte antigen 6 family member s)
D: ly-6k (homo sapiens) (aka lymphocyte antigen 6 fam... | [A; K] |
<Instruct>: Given the context 'Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd59; ly-6]
<Options>: A: cd58 (homo sapiens) (aka cd58 molecule)
B: ly-6d (homo sapiens) (aka lymphocyte antigen 6 family member d)
C: cd52 molecule (homo sapiens) (aka cd52 molecule)
D: lir-6 (homo sapiens) (aka leukocyte immunoglobulin like receptor a1)
E: ly5 (homo sapiens) (aka protein tyrosine phosph... | [F; K] |
<Instruct>: Given the context 'The gene for CD59 [membrane inhibitor of reactive lysis (MIRL), protectin], a phosphatidylinositol-linked surface glycoprotein that regulates the formation of the polymeric C9 complex of complement and that is deficient on the abnormal hematopoietic cells of patients with paroxysmal noctu... | <Mentions>: [cd59; membrane inhibitor of reactive lysis; mirl; protectin]
<Options>: A: cd52 molecule (homo sapiens) (aka cd52 molecule)
B: ribonuclease/angiogenin inhibitor 1 (mus musculus) (aka ribonuclease/angiogenin inhibitor 1)
C: migration and invasion inhibitory protein (bos taurus) (aka migration and invasion i... | [O; O; O; O] |
<Instruct>: Given the context 'The gene for CD59 [membrane inhibitor of reactive lysis (MIRL), protectin], a phosphatidylinositol-linked surface glycoprotein that regulates the formation of the polymeric C9 complex of complement and that is deficient on the abnormal hematopoietic cells of patients with paroxysmal noctu... | <Mentions>: [cd59; membrane inhibitor of reactive lysis; mirl; protectin]
<Options>: A: ribonuclease/angiogenin inhibitor 1 (mus musculus) (aka ribonuclease/angiogenin inhibitor 1)
B: mira (drosophila melanogaster) (aka miranda)
C: miro1 (homo sapiens) (aka ras homolog family member t1)
D: cd51 (homo sapiens) (aka inte... | [L; L; L; L] |
<Instruct>: Given the context 'The gene for CD59 [membrane inhibitor of reactive lysis (MIRL), protectin], a phosphatidylinositol-linked surface glycoprotein that regulates the formation of the polymeric C9 complex of complement and that is deficient on the abnormal hematopoietic cells of patients with paroxysmal noctu... | <Mentions>: [cd59; membrane inhibitor of reactive lysis; mirl; protectin]
<Options>: A: minute-like (drosophila melanogaster) (aka minute-like)
B: recoverin (homo sapiens) (aka recoverin)
C: fallotein (homo sapiens) (aka platelet derived growth factor c)
D: bmp and activin membrane bound inhibitor (homo sapiens) (aka b... | [K; K; K; K] |
<Instruct>: Given the context 'The gene for CD59 [membrane inhibitor of reactive lysis (MIRL), protectin], a phosphatidylinositol-linked surface glycoprotein that regulates the formation of the polymeric C9 complex of complement and that is deficient on the abnormal hematopoietic cells of patients with paroxysmal noctu... | <Mentions>: [cd59; membrane inhibitor of reactive lysis; mirl; protectin]
<Options>: A: recoverin (homo sapiens) (aka recoverin)
B: cd58 (homo sapiens) (aka cd58 molecule)
C: placentin (homo sapiens) (aka insulin like 4)
D: fallotein (homo sapiens) (aka platelet derived growth factor c)
E: serpinh1 (homo sapiens) (aka ... | [Q; Q; Q; Q] |
<Instruct>: Given the context 'The gene for CD59 [membrane inhibitor of reactive lysis (MIRL), protectin], a phosphatidylinositol-linked surface glycoprotein that regulates the formation of the polymeric C9 complex of complement and that is deficient on the abnormal hematopoietic cells of patients with paroxysmal noctu... | <Mentions>: [cd59; membrane inhibitor of reactive lysis; mirl; protectin]
<Options>: A: recoverin (homo sapiens) (aka recoverin)
B: cd51 (homo sapiens) (aka integrin subunit alpha v)
C: copper chaperone for superoxide dismutase (homo sapiens) (aka copper chaperone for superoxide dismutase)
D: minute-like (drosophila me... | [O; O; O; O] |
<Instruct>: Given the context 'The structure of the CD59 gene is very similar to that encoding Ly-6, a murine glycoprotein with which CD59 has some structural similarity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, se... | <Mentions>: [cd59; ly-6]
<Options>: A: lymphocyte antigen 6 family member h (homo sapiens) (aka lymphocyte antigen 6 family member h)
B: cd6 molecule (homo sapiens) (aka cd6 molecule)
C: cd52 (homo sapiens) (aka cd52 molecule)
D: cd59 molecule (cd59 blood group) (homo sapiens) (aka cd59 molecule (cd59 blood group))
E: ... | [D; K] |
<Instruct>: Given the context 'The structure of the CD59 gene is very similar to that encoding Ly-6, a murine glycoprotein with which CD59 has some structural similarity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, se... | <Mentions>: [cd59; ly-6]
<Options>: A: lir-6 (homo sapiens) (aka leukocyte immunoglobulin like receptor a1)
B: ly-6d (homo sapiens) (aka lymphocyte antigen 6 family member d)
C: cd52 molecule (homo sapiens) (aka cd52 molecule)
D: cd55 (homo sapiens) (aka cd55 molecule (cromer blood group))
E: slam family member 7 (homo... | [G; K] |
<Instruct>: Given the context 'The striking similarity in gene structure is further evidence that the two proteins belong to a superfamily of proteins that may also include the urokinase plasminogen-activator receptor and a squid glycoprotein of unknown function.', select the correct biomedical concept for each mention... | <Mentions>: [urokinase plasminogen-activator receptor]
<Options>: A: plasminogen activator, urokinase receptor (sus scrofa) (aka plasminogen activator, urokinase receptor)
B: plasminogen activator, urokinase receptor (bos taurus) (aka plasminogen activator, urokinase receptor)
C: plasminogen activator, urokinase (homo ... | [E] |
<Instruct>: Given the context 'Cloning and chromosome mapping of the human interleukin-1 receptor antagonist gene.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [interleukin-1 receptor antagonist]
<Options>: A: interleukin 36 receptor antagonist (homo sapiens) (aka interleukin 36 receptor antagonist)
B: il1rp1 (homo sapiens) (aka interleukin 37)
C: interleukin 1 receptor antagonist (mus musculus) (aka interleukin 1 receptor antagonist)
D: il1ra (homo sapiens) (inte... | [D] |
<Instruct>: Given the context 'Cloning and chromosome mapping of the human interleukin-1 receptor antagonist gene.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [interleukin-1 receptor antagonist]
<Options>: A: il11ra (homo sapiens) (aka interleukin 11 receptor subunit alpha)
B: il1rp1 (homo sapiens) (aka interleukin 37)
C: interleukin 1 receptor antagonist (mus musculus) (aka interleukin 1 receptor antagonist)
D: interleukin 36 receptor antagonist (homo sapiens) (... | [E] |
<Instruct>: Given the context 'By screening a human genomic library with an interleukin-1 receptor antagonist (IL-1ra) cDNA probe, we have isolated a 15 kb clone which contains the entire coding region of the gene as expressed in monocytes, and includes 6 kb of 5'-upstream sequence.', select the correct biomedical conc... | <Mentions>: [interleukin-1 receptor antagonist; il-1ra]
<Options>: A: il-1r-alpha (homo sapiens) (aka interleukin 1 receptor type 1)
B: il-1ra (homo sapiens) (interleukin 6 receptor (homo sapiens)) (aka interleukin 6 receptor)
C: il1rap (homo sapiens) (aka interleukin 1 receptor accessory protein)
D: il1ra (homo sapien... | [D; D] |
<Instruct>: Given the context 'By screening a human genomic library with an interleukin-1 receptor antagonist (IL-1ra) cDNA probe, we have isolated a 15 kb clone which contains the entire coding region of the gene as expressed in monocytes, and includes 6 kb of 5'-upstream sequence.', select the correct biomedical conc... | <Mentions>: [interleukin-1 receptor antagonist; il-1ra]
<Options>: A: il1rp1 (homo sapiens) (aka interleukin 37)
B: il-1rrp (homo sapiens) (aka interleukin 18 receptor 1)
C: interleukin 1 receptor antagonist (rattus norvegicus) (aka interleukin 1 receptor antagonist)
D: il11ra (homo sapiens) (aka interleukin 11 recepto... | [E; E] |
<Instruct>: Given the context 'The gene contains four exons which code for the secreted form of the IL-1ra, however, our clone does not contain the alternative first exon used to generate an intracellular form of the protein as the protein as found in epithelial cells.', select the correct biomedical concept for each m... | <Mentions>: [il-1ra]
<Options>: A: il1ra (homo sapiens) (interleukin 1 receptor antagonist (homo sapiens)) (aka interleukin 1 receptor antagonist)
B: il-1racp (homo sapiens) (aka interleukin 1 receptor accessory protein)
C: il-1ra (homo sapiens) (interleukin 6 receptor (homo sapiens)) (aka interleukin 6 receptor)
D: il... | [A] |
<Instruct>: Given the context 'By in-situ fluorescence hybridization we have shown that the IL-1ra gene is found on the long arm of chromosome 2 and maps to 2q13-14.1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [il-1ra]
<Options>: A: il-1rrp (homo sapiens) (aka interleukin 18 receptor 1)
B: il-1r-alpha (homo sapiens) (aka interleukin 1 receptor type 1)
C: il11ra (homo sapiens) (aka interleukin 11 receptor subunit alpha)
D: il-1ra (homo sapiens) (interleukin 1 receptor antagonist (homo sapiens)) (aka interleukin 1 ... | [D] |
<Instruct>: Given the context 'Previous studies have revealed that IL-1 alpha, and IL-1 beta and both type I and type II forms of the IL-1 receptor all map close to this region of chromosome 2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [il-1 alpha; il-1 beta]
<Options>: A: il-1h1 (homo sapiens) (aka interleukin 36 gamma)
B: interferon beta 1 (homo sapiens) (aka interferon beta 1)
C: interleukin 36 beta (homo sapiens) (aka interleukin 36 beta)
D: il-1 (homo sapiens) (aka interleukin 1 beta)
E: il1f1 (homo sapiens) (aka interleukin 1 alpha)... | [E; H] |
<Instruct>: Given the context 'Previous studies have revealed that IL-1 alpha, and IL-1 beta and both type I and type II forms of the IL-1 receptor all map close to this region of chromosome 2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [il-1 alpha; il-1 beta]
<Options>: A: il-1h1 (homo sapiens) (aka interleukin 36 gamma)
B: il1f1 (homo sapiens) (aka interleukin 1 alpha)
C: il-1 (homo sapiens) (aka interleukin 1 beta)
D: interleukin 36 beta (homo sapiens) (aka interleukin 36 beta)
E: ifn1@ (homo sapiens) (aka interferon, type 1, cluster)
F... | [B; C] |
<Instruct>: Given the context 'Previous studies have revealed that IL-1 alpha, and IL-1 beta and both type I and type II forms of the IL-1 receptor all map close to this region of chromosome 2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [il-1 alpha; il-1 beta]
<Options>: A: ifn1@ (homo sapiens) (aka interferon, type 1, cluster)
B: il1f1 (homo sapiens) (aka interleukin 1 alpha)
C: ifn-beta (homo sapiens) (aka interferon beta 1)
D: interleukin 36 beta (homo sapiens) (aka interleukin 36 beta)
E: interferon alpha 1 (homo sapiens) (aka interfer... | [B; G] |
<Instruct>: Given the context 'Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein.
Early-onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH) is an autosomal recessive neurodegenerative disorder characterized by early-onset ataxia, ocular motor apra... | <Mentions>: [aprataxin; eaoh; early-onset ataxia with ocular motor apraxia and hypoalbuminemia]
<Options>: A: aprataxin (drosophila melanogaster) (aka aprataxin)
B: etaa16 (homo sapiens) (aka etaa1 activator of atr kinase)
C: oohe (homo sapiens) (aka unc-45 myosin chaperone a)
D: aprataxin (xenopus tropicalis) (aka apr... | [L; L; L] |
<Instruct>: Given the context 'Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein.
Early-onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH) is an autosomal recessive neurodegenerative disorder characterized by early-onset ataxia, ocular motor apra... | <Mentions>: [aprataxin; eaoh; early-onset ataxia with ocular motor apraxia and hypoalbuminemia]
<Options>: A: aprataxin (homo sapiens) (aka aprataxin)
B: episodic ataxia, type 3 (homo sapiens) (aka episodic ataxia, type 3)
C: epilepsy, occipitotemporal lobe, and migraine with aura (homo sapiens) (aka epilepsy, occipito... | [A; A; A] |
<Instruct>: Given the context 'Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein.
Early-onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH) is an autosomal recessive neurodegenerative disorder characterized by early-onset ataxia, ocular motor apra... | <Mentions>: [aprataxin; eaoh; early-onset ataxia with ocular motor apraxia and hypoalbuminemia]
<Options>: A: eay (drosophila melanogaster) (eyes absent (drosophila melanogaster)) (aka eyes absent)
B: eaa1 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 4)
C: episodic ataxia, type 3 (homo sapiens... | [M; M; M] |
<Instruct>: Given the context 'Recently, the causative gene for EAOH, APTX, has been identified.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eaoh; aptx]
<Options>: A: etaa1 activator of atr kinase (homo sapiens) (aka etaa1 activator of atr kinase)
B: eay (drosophila melanogaster) (early (drosophila melanogaster)) (aka early)
C: aptx (xenopus tropicalis) (aka aprataxin)
D: aptx (mus musculus) (aka aprataxin)
E: eoaha (homo sapiens) (aka aprataxi... | [E; E] |
<Instruct>: Given the context 'Recently, the causative gene for EAOH, APTX, has been identified.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eaoh; aptx]
<Options>: A: eay (drosophila melanogaster) (early (drosophila melanogaster)) (aka early)
B: aptr (homo sapiens) (aka alu-mediated cdkn1a/p21 transcriptional regulator)
C: aptx.l (xenopus laevis) (aka aprataxin l homeolog)
D: aptx (drosophila melanogaster) (aka aprataxin)
E: oohe (homo sapiens)... | [G; G] |
<Instruct>: Given the context 'Of the two splicing variants of APTX mRNA, the short and the long forms, long-form APTX mRNA was found to be the major isoform.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [aptx]
<Options>: A: aptx (arabidopsis thaliana) (aka aprataxin-like protein)
B: aptx (homo sapiens) (aka aprataxin)
C: aptl (homo sapiens) (aka fas ligand)
D: apt1 (xenopus laevis) (fas cell surface death receptor s homeolog (xenopus laevis)) (aka fas cell surface death receptor s homeolog)
E: aptx (mus mu... | [B] |
<Instruct>: Given the context 'Aprataxin is mainly located in the nucleus, and, furthermore, the first nuclear localization signal located near the amino terminus of the long-form aprataxin is essential for its nuclear localization.', select the correct biomedical concept for each mention using the provided options. An... | <Mentions>: [aprataxin]
<Options>: A: aprataxin (homo sapiens) (aka aprataxin)
B: aprataxin-like (xenopus laevis) (aka aprataxin-like)
C: aprataxin (xenopus tropicalis) (aka aprataxin)
D: aprataxin (sus scrofa) (aka aprataxin)
E: aprataxin (mus musculus) (aka aprataxin)
F: None of the above. | [A] |
<Instruct>: Given the context 'We found, based on the yeast two-hybrid and coimmunoprecipitation experiments, that the long-form but not the short-form aprataxin interacts with XRCC1 (x-ray repair cross-complementing group 1).', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [aprataxin; xrcc1; x-ray repair cross-complementing group 1]
<Options>: A: xrcc1 (homo sapiens) (aka x-ray repair cross complementing 1)
B: xrcc11 (homo sapiens) (aka brca2 dna repair associated)
C: x-ray repair cross complementing 6 (homo sapiens) (aka x-ray repair cross complementing 6)
D: aprataxin-like ... | [K; A; A] |
<Instruct>: Given the context 'We found, based on the yeast two-hybrid and coimmunoprecipitation experiments, that the long-form but not the short-form aprataxin interacts with XRCC1 (x-ray repair cross-complementing group 1).', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [aprataxin; xrcc1; x-ray repair cross-complementing group 1]
<Options>: A: xrcc9 (homo sapiens) (aka fa complementation group g)
B: aprataxin (homo sapiens) (aka aprataxin)
C: xrcc11 (homo sapiens) (aka brca2 dna repair associated)
D: aprataxin and pnkp like factor (xenopus tropicalis) (aka aprataxin and pn... | [B; H; H] |
<Instruct>: Given the context 'We found, based on the yeast two-hybrid and coimmunoprecipitation experiments, that the long-form but not the short-form aprataxin interacts with XRCC1 (x-ray repair cross-complementing group 1).', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [aprataxin; xrcc1; x-ray repair cross-complementing group 1]
<Options>: A: x-ray repair cross complementing 4 (homo sapiens) (aka x-ray repair cross complementing 4)
B: x-ray repair cross complementing 6 (homo sapiens) (aka x-ray repair cross complementing 6)
C: aprataxin l homeolog (xenopus laevis) (aka ap... | [F; D; D] |
<Instruct>: Given the context 'Interestingly the amino terminus of the long-form aprataxin is homologous with polynucleotidekinase-3'-phosphatase, which has been demonstrated to be involved in base excision repair, a subtype of single-strand DNA break repair, through interaction with XRCC1, DNA polymerase beta, and DNA... | <Mentions>: [aprataxin; polynucleotidekinase-3'-phosphatase; xrcc1; dna polymerase beta]
<Options>: A: dna polymerase iota (homo sapiens) (aka dna polymerase iota)
B: polynucleotide kinase 3'-phosphatase (homo sapiens) (aka polynucleotide kinase 3'-phosphatase)
C: aprataxin-like (xenopus laevis) (aka aprataxin-like)
D:... | [L; B; T; O] |
<Instruct>: Given the context 'Interestingly the amino terminus of the long-form aprataxin is homologous with polynucleotidekinase-3'-phosphatase, which has been demonstrated to be involved in base excision repair, a subtype of single-strand DNA break repair, through interaction with XRCC1, DNA polymerase beta, and DNA... | <Mentions>: [aprataxin; polynucleotidekinase-3'-phosphatase; xrcc1; dna polymerase beta]
<Options>: A: x-ray repair cross complementing 1 (homo sapiens) (aka x-ray repair cross complementing 1)
B: dna polymerase gamma, catalytic subunit (homo sapiens) (aka dna polymerase gamma, catalytic subunit)
C: aprataxin (xenopus ... | [J; P; A; E] |
<Instruct>: Given the context 'Interestingly the amino terminus of the long-form aprataxin is homologous with polynucleotidekinase-3'-phosphatase, which has been demonstrated to be involved in base excision repair, a subtype of single-strand DNA break repair, through interaction with XRCC1, DNA polymerase beta, and DNA... | <Mentions>: [aprataxin; polynucleotidekinase-3'-phosphatase; xrcc1; dna polymerase beta]
<Options>: A: aprataxin (homo sapiens) (aka aprataxin)
B: xrcc1 (oryctolagus cuniculus) (aka x-ray repair cross complementing 1)
C: polynucleotide kinase 3'-phosphatase (xenopus tropicalis) (aka polynucleotide kinase 3'-phosphatase... | [A; H; N; T] |
<Instruct>: Given the context 'Interestingly the amino terminus of the long-form aprataxin is homologous with polynucleotidekinase-3'-phosphatase, which has been demonstrated to be involved in base excision repair, a subtype of single-strand DNA break repair, through interaction with XRCC1, DNA polymerase beta, and DNA... | <Mentions>: [aprataxin; polynucleotidekinase-3'-phosphatase; xrcc1; dna polymerase beta]
<Options>: A: polynucleotide kinase 3'-phosphatase (danio rerio) (aka polynucleotide kinase 3'-phosphatase)
B: dna polymerase gamma, catalytic subunit (homo sapiens) (aka dna polymerase gamma, catalytic subunit)
C: polynucleotide k... | [J; C; M; T] |
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