instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'HCC-1 has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hcc-1; mip-1 alpha]
<Options>: A: hccr1 (homo sapiens) (aka letm1 domain containing 1)
B: hcc5 (homo sapiens) (aka minichromosome maintenance complex component 3)
C: mip-1-alpha (homo sapiens) (aka c-c motif chemokine ligand 3)
D: hcc2 (homo sapiens) (aka thioredoxin domain containing 5)
E: hccs1 (homo sapiens) (aka vps53 subunit of garp complex)
F: mip-1d (homo sapiens) (aka c-c motif chemokine ligand 15)
G: hcc-1/hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
H: c-c motif chemokine ligand 1 (homo sapiens) (aka c-c motif chemokine ligand 1)
I: mip1b (homo sapiens) (aka c-c motif chemokine ligand 4)
J: c-x3-c motif chemokine ligand 1 (homo sapiens) (aka c-x3-c motif chemokine ligand 1)
K: None of the above. | [G; C] |
<Instruct>: Given the context 'HCC-1 has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hcc-1; mip-1 alpha]
<Options>: A: mip-3a (homo sapiens) (aka c-c motif chemokine ligand 20)
B: hcca1 (homo sapiens) (aka yy1 associated protein 1)
C: hcc5 (homo sapiens) (aka minichromosome maintenance complex component 3)
D: mip1b (homo sapiens) (aka c-c motif chemokine ligand 4)
E: hccs1 (homo sapiens) (aka vps53 subunit of garp complex)
F: hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
G: mip-1d (homo sapiens) (aka c-c motif chemokine ligand 15)
H: c-c motif chemokine ligand 1 (homo sapiens) (aka c-c motif chemokine ligand 1)
I: mip1a (homo sapiens) (aka c-c motif chemokine ligand 3)
J: hccr1 (homo sapiens) (aka letm1 domain containing 1)
K: None of the above. | [F; I] |
<Instruct>: Given the context 'HCC-1 has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hcc-1; mip-1 alpha]
<Options>: A: mip-3a (homo sapiens) (aka c-c motif chemokine ligand 20)
B: hcca1 (homo sapiens) (aka yy1 associated protein 1)
C: hcc5 (homo sapiens) (aka minichromosome maintenance complex component 3)
D: mip-1d (homo sapiens) (aka c-c motif chemokine ligand 15)
E: mip1b (homo sapiens) (aka c-c motif chemokine ligand 4)
F: hccs1 (homo sapiens) (aka vps53 subunit of garp complex)
G: hccr1 (homo sapiens) (aka letm1 domain containing 1)
H: c-c motif chemokine ligand 1 (homo sapiens) (aka c-c motif chemokine ligand 1)
I: hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
J: None of the above. | [I; J] |
<Instruct>: Given the context 'In addition, HCC-1 enhanced the proliferation of CD34+ myeloid progenitor cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hcc-1]
<Options>: A: hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
B: hccs1 (homo sapiens) (aka vps53 subunit of garp complex)
C: hccs-1 (homo sapiens) (aka suppressor of tumorigenicity 20)
D: hcc3 (homo sapiens) (aka fun14 domain containing 2)
E: hcc5 (homo sapiens) (aka minichromosome maintenance complex component 3)
F: None of the above. | [A] |
<Instruct>: Given the context 'It was as effective as MIP-1 alpha, but about 100-fold less potent.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mip-1 alpha]
<Options>: A: mip1b (homo sapiens) (aka c-c motif chemokine ligand 4)
B: mip1a (homo sapiens) (aka c-c motif chemokine ligand 3)
C: mip-4a (homo sapiens) (aka c-c motif chemokine ligand 26)
D: mip1ap (homo sapiens) (aka c-c motif chemokine ligand 3 like 1)
E: c-c motif chemokine ligand 1 (homo sapiens) (aka c-c motif chemokine ligand 1)
F: None of the above. | [B] |
<Instruct>: Given the context 'LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [laf-4; af-4; mll]
<Options>: A: transcription factor laf1-like (glycine max) (aka transcription factor laf1-like)
B: mll (mus musculus) (aka lysine (k)-specific methyltransferase 2a)
C: af1 (homo sapiens) (aka ephrin a5)
D: mll-af6 (homo sapiens) (aka afadin, adherens junction formation factor)
E: laf4l (rattus norvegicus) (aka alf transcription elongation factor 4)
F: af9 (homo sapiens) (aka mllt3 super elongation complex subunit)
G: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
H: af4 (homo sapiens) (aka alf transcription elongation factor 1)
I: af4/fmr2 family, member 4 (mus musculus) (aka af4/fmr2 family, member 4)
J: mllt2-like (homo sapiens) (aka alf transcription elongation factor 3)
K: mll1 (homo sapiens) (aka lysine methyltransferase 2a)
L: laf4 (rattus norvegicus) (aka alf transcription elongation factor 3)
M: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
N: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1)
O: None of the above. | [M; H; K] |
<Instruct>: Given the context 'LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [laf-4; af-4; mll]
<Options>: A: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11)
B: laf4 (rattus norvegicus) (aka alf transcription elongation factor 3)
C: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
D: laf4l (mus musculus) (aka af4/fmr2 family, member 4)
E: transcription factor laf1-like (glycine max) (aka transcription factor laf1-like)
F: af6 (homo sapiens) (aka afadin, adherens junction formation factor)
G: af9 (homo sapiens) (aka mllt3 super elongation complex subunit)
H: mll-af6 (homo sapiens) (aka afadin, adherens junction formation factor)
I: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1)
J: mll (homo sapiens) (aka lysine methyltransferase 2a)
K: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
L: mll (mus musculus) (aka lysine (k)-specific methyltransferase 2a)
M: laf4 (mus musculus) (aka af4/fmr2 family, member 3)
N: af4 (homo sapiens) (aka alf transcription elongation factor 1)
O: af10 (homo sapiens) (aka mllt10 histone lysine methyltransferase dot1l cofactor)
P: None of the above. | [C; N; J] |
<Instruct>: Given the context 'LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [laf-4; af-4; mll]
<Options>: A: laf4 (rattus norvegicus) (aka alf transcription elongation factor 3)
B: mllt2-like (homo sapiens) (aka alf transcription elongation factor 3)
C: mll (homo sapiens) (aka lysine methyltransferase 2a)
D: laf4l (mus musculus) (aka af4/fmr2 family, member 4)
E: transcription factor laf1-like (glycine max) (aka transcription factor laf1-like)
F: aff4 (homo sapiens) (aka alf transcription elongation factor 4)
G: af4/fmr2 family, member 4 (mus musculus) (aka af4/fmr2 family, member 4)
H: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11)
I: af4 (homo sapiens) (aka alf transcription elongation factor 1)
J: mll-af6 (homo sapiens) (aka afadin, adherens junction formation factor)
K: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
L: af10 (homo sapiens) (aka mllt10 histone lysine methyltransferase dot1l cofactor)
M: laf4 (mus musculus) (aka af4/fmr2 family, member 3)
N: af4/fmr2 family member 4 (xenopus tropicalis) (aka af4/fmr2 family member 4)
O: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1)
P: None of the above. | [K; I; C] |
<Instruct>: Given the context 'A novel human gene, LAF-4, was isolated from a subtracted cDNA library that showed strong sequence similarity to AF-4, a gene that is translocated in t(4;11)(q21;q23) acute lymphoblastic leukemias (ALLs).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [laf-4; af-4]
<Options>: A: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
B: af4 (homo sapiens) (aka alf transcription elongation factor 1)
C: af10 (homo sapiens) (aka mllt10 histone lysine methyltransferase dot1l cofactor)
D: transcription factor laf1-like (glycine max) (aka transcription factor laf1-like)
E: af4/fmr2 family, member 4 (mus musculus) (aka af4/fmr2 family, member 4)
F: laf4 (rattus norvegicus) (aka alf transcription elongation factor 3)
G: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
H: af4 (mus musculus) (af4/fmr2 family, member 1 (mus musculus)) (aka af4/fmr2 family, member 1)
I: None of the above. | [A; B] |
<Instruct>: Given the context 'A novel human gene, LAF-4, was isolated from a subtracted cDNA library that showed strong sequence similarity to AF-4, a gene that is translocated in t(4;11)(q21;q23) acute lymphoblastic leukemias (ALLs).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [laf-4; af-4]
<Options>: A: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
B: af4/fmr2 family, member 4 (mus musculus) (aka af4/fmr2 family, member 4)
C: af1 (homo sapiens) (aka ephrin a5)
D: laf4l (mus musculus) (aka af4/fmr2 family, member 4)
E: af6 (homo sapiens) (aka afadin, adherens junction formation factor)
F: af9 (homo sapiens) (aka mllt3 super elongation complex subunit)
G: laf4 (mus musculus) (aka af4/fmr2 family, member 3)
H: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
I: af4 (homo sapiens) (aka alf transcription elongation factor 1)
J: None of the above. | [A; I] |
<Instruct>: Given the context 'In t(4;11) ALL, the AF-4 gene at 4q21 is translocated into the MLL locus at 11q23, resulting in the expression of an MLL/AF-4 fusion protein that is the presumptive oncoprotein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [af-4; mll]
<Options>: A: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
B: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1)
C: af9 (homo sapiens) (aka mllt3 super elongation complex subunit)
D: af4/fmr2 family member 4 (xenopus tropicalis) (aka af4/fmr2 family member 4)
E: mll1 (homo sapiens) (aka lysine methyltransferase 2a)
F: mll (mus musculus) (aka lysine (k)-specific methyltransferase 2a)
G: af4 (homo sapiens) (aka alf transcription elongation factor 1)
H: af6 (homo sapiens) (aka afadin, adherens junction formation factor)
I: mll-af6 (homo sapiens) (aka afadin, adherens junction formation factor)
J: None of the above. | [G; E] |
<Instruct>: Given the context 'In t(4;11) ALL, the AF-4 gene at 4q21 is translocated into the MLL locus at 11q23, resulting in the expression of an MLL/AF-4 fusion protein that is the presumptive oncoprotein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [af-4; mll]
<Options>: A: af4 (mus musculus) (af4/fmr2 family, member 1 (mus musculus)) (aka af4/fmr2 family, member 1)
B: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1)
C: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11)
D: af1 (homo sapiens) (aka ephrin a5)
E: af4/fmr2 family, member 4 (mus musculus) (aka af4/fmr2 family, member 4)
F: mllt7 (homo sapiens) (aka forkhead box o4)
G: af4 (homo sapiens) (aka alf transcription elongation factor 1)
H: mll (mus musculus) (aka lysine (k)-specific methyltransferase 2a)
I: mll1 (homo sapiens) (aka lysine methyltransferase 2a)
J: af6 (homo sapiens) (aka afadin, adherens junction formation factor)
K: None of the above. | [G; I] |
<Instruct>: Given the context 'AF-4 and LAF-4 are homologous throughout their coding regions, yet neither protein is related to previously cloned genes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [af-4; laf-4]
<Options>: A: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
B: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
C: transcription factor laf1-like (glycine max) (aka transcription factor laf1-like)
D: af9 (homo sapiens) (aka mllt3 super elongation complex subunit)
E: af4 (homo sapiens) (aka alf transcription elongation factor 1)
F: laf4 (rattus norvegicus) (aka alf transcription elongation factor 3)
G: laf-4 (mus musculus) (aka af4/fmr2 family, member 3)
H: af1 (homo sapiens) (aka ephrin a5)
I: af4 (mus musculus) (af4/fmr2 family, member 1 (mus musculus)) (aka af4/fmr2 family, member 1)
J: None of the above. | [E; A] |
<Instruct>: Given the context 'AF-4 and LAF-4 are homologous throughout their coding regions, yet neither protein is related to previously cloned genes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [af-4; laf-4]
<Options>: A: aff4 (homo sapiens) (aka alf transcription elongation factor 4)
B: af4/fmr2 family member 4 (xenopus tropicalis) (aka af4/fmr2 family member 4)
C: transcription factor laf1-like (glycine max) (aka transcription factor laf1-like)
D: laf4 (rattus norvegicus) (aka alf transcription elongation factor 3)
E: af4 (homo sapiens) (aka alf transcription elongation factor 1)
F: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
G: af10 (homo sapiens) (aka mllt10 histone lysine methyltransferase dot1l cofactor)
H: af4 (mus musculus) (af4/fmr2 family, member 1 (mus musculus)) (aka af4/fmr2 family, member 1)
I: af4/fmr2 family, member 4 (mus musculus) (aka af4/fmr2 family, member 4)
J: None of the above. | [E; F] |
<Instruct>: Given the context 'Human LAF-4 readily hybridized with genes in mouse and chicken, thus showing that this gene family has been highly conserved during vertebrate evolution.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [laf-4]
<Options>: A: af4 (homo sapiens) (aka alf transcription elongation factor 1)
B: laf-4 (mus musculus) (aka af4/fmr2 family, member 3)
C: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
D: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
E: laf4 (rattus norvegicus) (aka alf transcription elongation factor 3)
F: None of the above. | [C] |
<Instruct>: Given the context 'In mouse tissues, LAF-4 mRNA was found to be present at highest levels in lymphoid tissues, present at lower levels in brain and lung, and absent from other tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [laf-4]
<Options>: A: laf-4 (mus musculus) (aka af4/fmr2 family, member 3)
B: laf4l (rattus norvegicus) (aka alf transcription elongation factor 4)
C: aff4 (homo sapiens) (aka alf transcription elongation factor 4)
D: transcription factor laf1-like (glycine max) (aka transcription factor laf1-like)
E: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
F: None of the above. | [E] |
<Instruct>: Given the context 'In human and mouse lymphoid cell lines, LAF-4 expression was highest in pre-B cells, intermediate in mature B cells, and absent in plasma cells, thus pointing to a potential regulatory role for LAF-4 in lymphoid development.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [laf-4]
<Options>: A: laf4 (rattus norvegicus) (aka alf transcription elongation factor 3)
B: transcription factor laf1-like (glycine max) (aka transcription factor laf1-like)
C: af4 (homo sapiens) (aka alf transcription elongation factor 1)
D: laf4l (mus musculus) (aka af4/fmr2 family, member 4)
E: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
F: None of the above. | [E] |
<Instruct>: Given the context 'Antibodies to LAF-4 showed it to be a nuclear protein that showed an uneven, granular immunofluorescence pattern.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [laf-4]
<Options>: A: transcription factor laf1-like (glycine max) (aka transcription factor laf1-like)
B: af4 (homo sapiens) (aka alf transcription elongation factor 1)
C: laf4 (rattus norvegicus) (aka alf transcription elongation factor 3)
D: laf4l (mus musculus) (aka af4/fmr2 family, member 4)
E: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
F: None of the above. | [E] |
<Instruct>: Given the context 'In vitro-translated LAF-4 was able to bind strongly to double-stranded DNA cellulose.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [laf-4]
<Options>: A: transcription factor laf1-like (glycine max) (aka transcription factor laf1-like)
B: laf-4 (mus musculus) (aka af4/fmr2 family, member 3)
C: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
D: af4 (homo sapiens) (aka alf transcription elongation factor 1)
E: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
F: None of the above. | [E] |
<Instruct>: Given the context 'Furthermore, both LAF-4 and AF-4 had domains that activated transcription strongly when fused to the GAL4 DNA-binding domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [laf-4; af-4]
<Options>: A: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
B: af1 (homo sapiens) (aka ephrin a5)
C: af4 (homo sapiens) (aka alf transcription elongation factor 1)
D: laf4l (rattus norvegicus) (aka alf transcription elongation factor 4)
E: transcription factor laf1-like (glycine max) (aka transcription factor laf1-like)
F: af10 (homo sapiens) (aka mllt10 histone lysine methyltransferase dot1l cofactor)
G: af4/fmr2 family, member 4 (mus musculus) (aka af4/fmr2 family, member 4)
H: aff4 (homo sapiens) (aka alf transcription elongation factor 4)
I: None of the above. | [A; C] |
<Instruct>: Given the context 'Furthermore, both LAF-4 and AF-4 had domains that activated transcription strongly when fused to the GAL4 DNA-binding domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [laf-4; af-4]
<Options>: A: af4 (homo sapiens) (aka alf transcription elongation factor 1)
B: aff4 (homo sapiens) (aka alf transcription elongation factor 4)
C: laf4l (rattus norvegicus) (aka alf transcription elongation factor 4)
D: af1 (homo sapiens) (aka ephrin a5)
E: af4/fmr2 family, member 4 (mus musculus) (aka af4/fmr2 family, member 4)
F: transcription factor laf1-like (glycine max) (aka transcription factor laf1-like)
G: af10 (homo sapiens) (aka mllt10 histone lysine methyltransferase dot1l cofactor)
H: None of the above. | [H; A] |
<Instruct>: Given the context 'Furthermore, both LAF-4 and AF-4 had domains that activated transcription strongly when fused to the GAL4 DNA-binding domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [laf-4; af-4]
<Options>: A: aff4 (homo sapiens) (aka alf transcription elongation factor 4)
B: transcription factor laf1-like (glycine max) (aka transcription factor laf1-like)
C: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
D: af9 (homo sapiens) (aka mllt3 super elongation complex subunit)
E: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
F: af1 (homo sapiens) (aka ephrin a5)
G: af6 (homo sapiens) (aka afadin, adherens junction formation factor)
H: af4 (homo sapiens) (aka alf transcription elongation factor 1)
I: None of the above. | [E; H] |
<Instruct>: Given the context 'Interestingly, the AF-4 transactivation domain is retained in the MLL/AF-4 fusion protein; thus, it may contribute to the transforming potential of the oncoprotein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mll; af-4]
<Options>: A: mll (mus musculus) (aka lysine (k)-specific methyltransferase 2a)
B: mll-af6 (homo sapiens) (aka afadin, adherens junction formation factor)
C: mllt2-like (homo sapiens) (aka alf transcription elongation factor 3)
D: af4/fmr2 family, member 4 (mus musculus) (aka af4/fmr2 family, member 4)
E: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
F: af1 (homo sapiens) (aka ephrin a5)
G: af4 (homo sapiens) (aka alf transcription elongation factor 1)
H: mllt1 super elongation complex subunit (homo sapiens) (aka mllt1 super elongation complex subunit)
I: mll (homo sapiens) (aka lysine methyltransferase 2a)
J: af10 (homo sapiens) (aka mllt10 histone lysine methyltransferase dot1l cofactor)
K: None of the above. | [I; G] |
<Instruct>: Given the context 'Interestingly, the AF-4 transactivation domain is retained in the MLL/AF-4 fusion protein; thus, it may contribute to the transforming potential of the oncoprotein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mll; af-4]
<Options>: A: af4 (mus musculus) (af4/fmr2 family, member 1 (mus musculus)) (aka af4/fmr2 family, member 1)
B: af4 (homo sapiens) (aka alf transcription elongation factor 1)
C: mllt1 super elongation complex subunit (homo sapiens) (aka mllt1 super elongation complex subunit)
D: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1)
E: mllt2-like (homo sapiens) (aka alf transcription elongation factor 3)
F: mll-af6 (homo sapiens) (aka afadin, adherens junction formation factor)
G: af9 (homo sapiens) (aka mllt3 super elongation complex subunit)
H: mll1 (homo sapiens) (aka lysine methyltransferase 2a)
I: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
J: af4/fmr2 family, member 4 (mus musculus) (aka af4/fmr2 family, member 4)
K: None of the above. | [H; B] |
<Instruct>: Given the context 'Therefore, the cloning of LAF-4 has defined a new family of potential regulatory proteins that may function in lymphoid development and oncogenesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [laf-4]
<Options>: A: laf-4 (mus musculus) (aka af4/fmr2 family, member 3)
B: laf4 (rattus norvegicus) (aka alf transcription elongation factor 3)
C: transcription factor laf1-like (glycine max) (aka transcription factor laf1-like)
D: laf4l (mus musculus) (aka af4/fmr2 family, member 4)
E: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
F: None of the above. | [E] |
<Instruct>: Given the context 'L-UBC encodes a protein that demonstrates homology to the yeast ubiquitin conjugating enzyme, UBC-4, and human UbcH5.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ubc-4; ubch5]
<Options>: A: ube2cp4 (homo sapiens) (aka ubiquitin conjugating enzyme e2 c pseudogene 4)
B: ubch (homo sapiens) (aka ubiquitin conjugating enzyme e2 h)
C: ubch5a (homo sapiens) (aka ubiquitin conjugating enzyme e2 d1)
D: ubch5b (homo sapiens) (aka ubiquitin conjugating enzyme e2 d2)
E: ube2l5 (homo sapiens) (aka ubiquitin conjugating enzyme e2 l5)
F: ubc4 (glycine max) (aka ubiquitin carrier protein 4)
G: e2 ubiquitin-conjugating protein ubc4 (saccharomyces cerevisiae s288c) (aka e2 ubiquitin-conjugating protein ubc4)
H: ubch5c (homo sapiens) (aka ubiquitin conjugating enzyme e2 d3)
I: ube2f (homo sapiens) (aka ubiquitin conjugating enzyme e2 f (putative))
J: ubch4 (homo sapiens) (aka ubiquitin conjugating enzyme e2 d2)
K: None of the above. | [G; C] |
<Instruct>: Given the context 'L-UBC encodes a protein that demonstrates homology to the yeast ubiquitin conjugating enzyme, UBC-4, and human UbcH5.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ubc-4; ubch5]
<Options>: A: ubc8 (homo sapiens) (aka ubiquitin conjugating enzyme e2 h)
B: ubch7 (homo sapiens) (aka ubiquitin conjugating enzyme e2 l3)
C: ubch5 (homo sapiens) (aka ubiquitin conjugating enzyme e2 d1)
D: ubc4 (glycine max) (aka ubiquitin carrier protein 4)
E: ube2l5 (homo sapiens) (aka ubiquitin conjugating enzyme e2 l5)
F: ube2cp4 (homo sapiens) (aka ubiquitin conjugating enzyme e2 c pseudogene 4)
G: e2 ubiquitin-conjugating protein ubc4 (saccharomyces cerevisiae s288c) (aka e2 ubiquitin-conjugating protein ubc4)
H: ubch (homo sapiens) (aka ubiquitin conjugating enzyme e2 h)
I: ubc4 (drosophila melanogaster) (ubiquitin conjugating enzyme 4 (drosophila melanogaster)) (aka ubiquitin conjugating enzyme 4)
J: ubch5b (homo sapiens) (aka ubiquitin conjugating enzyme e2 d2)
K: None of the above. | [G; C] |
<Instruct>: Given the context 'The protein also exhibits very strong homology to a rabbit protein, E2-F1, which mediates p53 degradation driven by papilloma virus E6 protein in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e2-f1; p53; e6]
<Options>: A: rad53 (homo sapiens) (aka checkpoint kinase 2)
B: protein e6*;transforming protein e6 (human papillomavirus 16) (aka protein e6*;transforming protein e6)
C: ct53 (homo sapiens) (aka zinc finger protein 165)
D: gtf2e2 (gallus gallus) (aka general transcription factor iie subunit 2)
E: e2-f1 (xenopus tropicalis) (aka ubiquitin conjugating enzyme e2 l3)
F: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
G: p53cp (homo sapiens) (aka tumor protein p63)
H: ube2f (homo sapiens) (aka ubiquitin conjugating enzyme e2 f (putative))
I: e2-epf (homo sapiens) (aka ubiquitin conjugating enzyme e2 s)
J: e1^e4 (human papillomavirus 16) (aka cell cycle modulating protein e1^e4)
K: e5 (human papillomavirus 16) (aka transforming protein e5)
L: trp53 (homo sapiens) (aka tumor protein p53)
M: gtf2e1 (gallus gallus) (aka general transcription factor iie subunit 1)
N: e1 (human papillomavirus 16) (aka replication protein e1)
O: transforming protein e7 (human papillomavirus 16) (aka transforming protein e7)
P: None of the above. | [P; L; B] |
<Instruct>: Given the context 'The protein also exhibits very strong homology to a rabbit protein, E2-F1, which mediates p53 degradation driven by papilloma virus E6 protein in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e2-f1; p53; e6]
<Options>: A: tp53 (homo sapiens) (aka tumor protein p53)
B: transforming protein e7 (human papillomavirus 16) (aka transforming protein e7)
C: ube2f (homo sapiens) (aka ubiquitin conjugating enzyme e2 f (putative))
D: gtf2f2 (gallus gallus) (aka general transcription factor iif subunit 2)
E: ubiquitin conjugating enzyme e2 f (putative) (gallus gallus) (aka ubiquitin conjugating enzyme e2 f (putative))
F: tp73 (homo sapiens) (aka tumor protein p73)
G: e6-ap (homo sapiens) (aka ubiquitin protein ligase e3a)
H: e1^e4 (human papillomavirus 16) (aka cell cycle modulating protein e1^e4)
I: e2-epf (homo sapiens) (aka ubiquitin conjugating enzyme e2 s)
J: ct53 (homo sapiens) (aka zinc finger protein 165)
K: e6 (human papillomavirus 16) (aka protein e6*;transforming protein e6)
L: e1 (human papillomavirus 16) (aka replication protein e1)
M: gtf2e1 (gallus gallus) (aka general transcription factor iie subunit 1)
N: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
O: rad53 (homo sapiens) (aka checkpoint kinase 2)
P: None of the above. | [P; A; K] |
<Instruct>: Given the context 'The protein also exhibits very strong homology to a rabbit protein, E2-F1, which mediates p53 degradation driven by papilloma virus E6 protein in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e2-f1; p53; e6]
<Options>: A: e1 (human papillomavirus 16) (aka replication protein e1)
B: ube2f (homo sapiens) (aka ubiquitin conjugating enzyme e2 f (putative))
C: tumor protein p73 (homo sapiens) (aka tumor protein p73)
D: e2-f1 (homo sapiens) (aka ubiquitin conjugating enzyme e2 l3)
E: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
F: protein e6*;transforming protein e6 (human papillomavirus 16) (aka protein e6*;transforming protein e6)
G: gtf2f2 (gallus gallus) (aka general transcription factor iif subunit 2)
H: ct53 (homo sapiens) (aka zinc finger protein 165)
I: e6-ap (homo sapiens) (aka ubiquitin protein ligase e3a)
J: trp53 (homo sapiens) (aka tumor protein p53)
K: ubiquitin conjugating enzyme e2 f (putative) (gallus gallus) (aka ubiquitin conjugating enzyme e2 f (putative))
L: e7 (human papillomavirus 16) (aka transforming protein e7)
M: p53cp (homo sapiens) (aka tumor protein p63)
N: e1^e4 (human papillomavirus 16) (aka cell cycle modulating protein e1^e4)
O: e2-epf (homo sapiens) (aka ubiquitin conjugating enzyme e2 s)
P: None of the above. | [P; J; F] |
<Instruct>: Given the context 'The protein also exhibits very strong homology to a rabbit protein, E2-F1, which mediates p53 degradation driven by papilloma virus E6 protein in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e2-f1; p53; e6]
<Options>: A: e1 (human papillomavirus 16) (aka replication protein e1)
B: e1^e4 (human papillomavirus 16) (aka cell cycle modulating protein e1^e4)
C: trp53 (homo sapiens) (aka tumor protein p53)
D: e2-f1 (homo sapiens) (aka ubiquitin conjugating enzyme e2 l3)
E: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
F: tumor protein p73 (homo sapiens) (aka tumor protein p73)
G: ubiquitin conjugating enzyme e2 f (putative) (gallus gallus) (aka ubiquitin conjugating enzyme e2 f (putative))
H: gtf2f2 (gallus gallus) (aka general transcription factor iif subunit 2)
I: ube2f (homo sapiens) (aka ubiquitin conjugating enzyme e2 f (putative))
J: p53cp (homo sapiens) (aka tumor protein p63)
K: e2-epf (homo sapiens) (aka ubiquitin conjugating enzyme e2 s)
L: e6-ap (homo sapiens) (aka ubiquitin protein ligase e3a)
M: ct53 (homo sapiens) (aka zinc finger protein 165)
N: e7 (human papillomavirus 16) (aka transforming protein e7)
O: None of the above. | [O; C; O] |
<Instruct>: Given the context 'Cloning, chromosomal localization, and tissue expression of autotaxin from human teratocarcinoma cells.
Autotaxin, a potent human tumor cell motility-stimulating exophosphodiesterase, was isolated and cloned from the human teratocarcinoma cell line NTera2D1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [autotaxin]
<Options>: A: transcriptional regulator atrx homolog (xenopus tropicalis) (aka transcriptional regulator atrx homolog)
B: metaxin-1 homolog (caenorhabditis elegans) (aka metaxin-1 homolog)
C: autotaxin (homo sapiens) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2)
D: autotaxin (xenopus laevis) (ectonucleotide pyrophosphatase/phosphodiesterase 2 s homeolog (xenopus laevis)) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2 s homeolog)
E: autotaxin (xenopus laevis) (ectonucleotide pyrophosphatase/phosphodiesterase 2 l homeolog (xenopus laevis)) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2 l homeolog)
F: None of the above. | [C] |
<Instruct>: Given the context 'The deduced amino acid sequence for the teratocarcinoma autotaxin has 94% identity to the melanoma-derived protein, 90% identity to rat brain phosphodiesterase I/nucleotide pyrophosphatase (PD-I alpha), and 44% identity to the plasma cell membrane marker PC-I. Utilizing polymerase chain reaction screening of the CEPH YAC library, we localized the autotaxin gene to human chromosome 8q23-24.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [autotaxin; pd-i alpha]
<Options>: A: pd-ialpha (homo sapiens) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2)
B: transcriptional regulator atrx homolog (xenopus tropicalis) (aka transcriptional regulator atrx homolog)
C: metaxin-1 homolog (caenorhabditis elegans) (aka metaxin-1 homolog)
D: transcriptional regulator atrx homolog (caenorhabditis elegans) (aka transcriptional regulator atrx homolog)
E: pd-ibeta (homo sapiens) (aka ectonucleotide pyrophosphatase/phosphodiesterase 3)
F: atx1 (arabidopsis thaliana) (homologue of trithorax (arabidopsis thaliana)) (aka homologue of trithorax)
G: pdcd1l1 (homo sapiens) (aka cd274 molecule)
H: atx-x (homo sapiens) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2)
I: pd-1h (homo sapiens) (aka v-set immunoregulatory receptor)
J: pd1 (homo sapiens) (programmed cell death 1 (homo sapiens)) (aka programmed cell death 1)
K: None of the above. | [H; K] |
<Instruct>: Given the context 'The deduced amino acid sequence for the teratocarcinoma autotaxin has 94% identity to the melanoma-derived protein, 90% identity to rat brain phosphodiesterase I/nucleotide pyrophosphatase (PD-I alpha), and 44% identity to the plasma cell membrane marker PC-I. Utilizing polymerase chain reaction screening of the CEPH YAC library, we localized the autotaxin gene to human chromosome 8q23-24.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [autotaxin; pd-i alpha]
<Options>: A: autotaxin (xenopus laevis) (ectonucleotide pyrophosphatase/phosphodiesterase 2 l homeolog (xenopus laevis)) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2 l homeolog)
B: autotaxina (xenopus tropicalis) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2)
C: pd-1h (homo sapiens) (aka v-set immunoregulatory receptor)
D: pd-ialpha (homo sapiens) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2)
E: pd-1 (homo sapiens) (programmed cell death 1 (homo sapiens)) (aka programmed cell death 1)
F: atx1 (arabidopsis thaliana) (homologue of trithorax (arabidopsis thaliana)) (aka homologue of trithorax)
G: atx-x (homo sapiens) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2)
H: pd-ibeta (homo sapiens) (aka ectonucleotide pyrophosphatase/phosphodiesterase 3)
I: autotaxin (xenopus laevis) (ectonucleotide pyrophosphatase/phosphodiesterase 2 s homeolog (xenopus laevis)) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2 s homeolog)
J: pd-l1 (homo sapiens) (aka cd274 molecule)
K: None of the above. | [G; K] |
<Instruct>: Given the context 'Northern blot analysis of relative mRNA from multiple human tissues revealed that autotaxin mRNA steady state expression is most abundant in brain, placenta, ovary, and small intestine.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [autotaxin]
<Options>: A: transcriptional regulator atrx homolog (xenopus tropicalis) (aka transcriptional regulator atrx homolog)
B: atx1 (arabidopsis thaliana) (homologue of trithorax (arabidopsis thaliana)) (aka homologue of trithorax)
C: transcriptional regulator atrx homolog (caenorhabditis elegans) (aka transcriptional regulator atrx homolog)
D: autotaxin (homo sapiens) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2)
E: atx1 (arabidopsis thaliana) (homolog of anti-oxidant 1 (arabidopsis thaliana)) (aka homolog of anti-oxidant 1)
F: None of the above. | [D] |
<Instruct>: Given the context 'Molecular cloning and characterization of a putative novel human osteoclast-specific 116-kDa vacuolar proton pump subunit.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [osteoclast-specific 116-kda]
<Options>: A: oc-116 (mus musculus) (aka t cell, immune regulator 1, atpase, h+ transporting, lysosomal v0 protein a3)
B: oc116 (homo sapiens) (aka t cell immune regulator 1, atpase h+ transporting v0 subunit a3)
C: transmembrane protein 116 (oryctolagus cuniculus) (aka transmembrane protein 116)
D: transmembrane protein 116 (homo sapiens) (aka transmembrane protein 116)
E: srh-116 (caenorhabditis elegans) (aka serpentine receptor, class h)
F: None of the above. | [B] |
<Instruct>: Given the context 'A cDNA encoding a possible novel human 116-kDa polypeptide subunit of the osteoclastic proton pump (OC-116KDa) has been identified by differential screening of a human osteoclastoma cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [116-kda polypeptide subunit of the osteoclastic proton pump; oc-116kda]
<Options>: A: transmembrane protein 116 (xenopus tropicalis) (aka transmembrane protein 116)
B: vomeronasal type-2 receptor 116-like (oryctolagus cuniculus) (loc108176155 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116-like)
C: oc-116 (mus musculus) (aka t cell, immune regulator 1, atpase, h+ transporting, lysosomal v0 protein a3)
D: vomeronasal type-2 receptor 116 (oryctolagus cuniculus) (loc100339134 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116)
E: v-type proton atpase 116 kda subunit a 1 (caenorhabditis elegans) (aka v-type proton atpase 116 kda subunit a 1)
F: transmembrane protein 116 (homo sapiens) (aka transmembrane protein 116)
G: vomeronasal type-2 receptor 116-like (oryctolagus cuniculus) (loc108176111 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116-like)
H: oc-116kda (homo sapiens) (aka t cell immune regulator 1, atpase h+ transporting v0 subunit a3)
I: None of the above. | [H; H] |
<Instruct>: Given the context 'A cDNA encoding a possible novel human 116-kDa polypeptide subunit of the osteoclastic proton pump (OC-116KDa) has been identified by differential screening of a human osteoclastoma cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [116-kda polypeptide subunit of the osteoclastic proton pump; oc-116kda]
<Options>: A: transmembrane protein 116 (oryctolagus cuniculus) (aka transmembrane protein 116)
B: transmembrane protein 116 (xenopus tropicalis) (aka transmembrane protein 116)
C: v-atpase 116 kda (mus musculus) (aka atpase, h+ transporting, lysosomal v0 subunit a2)
D: vomeronasal type-2 receptor 116 (oryctolagus cuniculus) (loc100339134 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116)
E: vomeronasal type-2 receptor 116-like (oryctolagus cuniculus) (loc108176111 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116-like)
F: v-type proton atpase 116 kda subunit a 1 (caenorhabditis elegans) (aka v-type proton atpase 116 kda subunit a 1)
G: vomeronasal type-2 receptor 116 (oryctolagus cuniculus) (loc108176177 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116)
H: oc-116 (mus musculus) (aka t cell, immune regulator 1, atpase, h+ transporting, lysosomal v0 protein a3)
I: oc-116kda (homo sapiens) (aka t cell immune regulator 1, atpase h+ transporting v0 subunit a3)
J: None of the above. | [I; I] |
<Instruct>: Given the context 'The predicted sequence of OC-116kDa consists of 822 amino acids and is 46.9% and 47.2% identical at the amino acid level to the 116-KDa polypeptide of the vacuolar proton pump of rat and bovine brain respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [oc-116kda]
<Options>: A: vomeronasal type-2 receptor 116 (oryctolagus cuniculus) (loc100355985 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116)
B: vomeronasal type-2 receptor 116 (oryctolagus cuniculus) (loc108176177 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116)
C: vomeronasal type-2 receptor 116-like (oryctolagus cuniculus) (loc108176155 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116-like)
D: vomeronasal type-2 receptor 116-like (oryctolagus cuniculus) (loc108176111 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116-like)
E: oc-116kda (homo sapiens) (aka t cell immune regulator 1, atpase h+ transporting v0 subunit a3)
F: None of the above. | [E] |
<Instruct>: Given the context 'OC-116KDa mRNA was found at high levels in osteoclastomas by Northern analysis but was not detected in tumor stromal cells or in other tissues including kidney, liver, skeletal muscle and brain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [oc-116kda]
<Options>: A: oc-116 (mus musculus) (aka t cell, immune regulator 1, atpase, h+ transporting, lysosomal v0 protein a3)
B: transmembrane protein 116 (oryctolagus cuniculus) (aka transmembrane protein 116)
C: oc-116kda (homo sapiens) (aka t cell immune regulator 1, atpase h+ transporting v0 subunit a3)
D: vomeronasal type-2 receptor 116-like (oryctolagus cuniculus) (loc108176111 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116-like)
E: vomeronasal type-2 receptor 116-like (oryctolagus cuniculus) (loc108176155 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116-like)
F: None of the above. | [C] |
<Instruct>: Given the context 'OC-116KDa mRNA was localized to multinucleated giant cells within the osteoclastoma tumor by in situ hybridization.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [oc-116kda]
<Options>: A: vomeronasal type-2 receptor 116-like (oryctolagus cuniculus) (loc108176155 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116-like)
B: vomeronasal type-2 receptor 116-like (oryctolagus cuniculus) (loc108176111 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116-like)
C: vomeronasal type-2 receptor 116 (oryctolagus cuniculus) (loc100343768 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116)
D: vomeronasal type-2 receptor 116 (oryctolagus cuniculus) (loc100339134 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116)
E: oc-116kda (homo sapiens) (aka t cell immune regulator 1, atpase h+ transporting v0 subunit a3)
F: None of the above. | [E] |
<Instruct>: Given the context 'The ubiquitously expressed pICln protein forms homomeric complexes in vitro.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [picln]
<Options>: A: cttn-like (xenopus tropicalis) (aka hematopoietic cell-specific lyn substrate 1)
B: methylosome subunit picln-like (bos taurus) (aka methylosome subunit picln-like)
C: pinin-like (xenopus tropicalis) (aka pinin-like)
D: cntln (homo sapiens) (aka centlein)
E: cdkn2a interacting protein n-terminal like (bos taurus) (aka cdkn2a interacting protein n-terminal like)
F: None of the above. | [F] |
<Instruct>: Given the context 'The latter current has been associated with the ICln protein (pICln) which may be the chloride channel itself or, alternatively, a channel regulator.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [icln; picln]
<Options>: A: icln (xenopus laevis) (chloride channel, nucleotide-sensitive, 1a l homeolog (xenopus laevis)) (aka chloride channel, nucleotide-sensitive, 1a l homeolog)
B: icln (homo sapiens) (chloride nucleotide-sensitive channel 1a (homo sapiens)) (aka chloride nucleotide-sensitive channel 1a)
C: cdkn2a interacting protein n-terminal like (xenopus tropicalis) (aka cdkn2a interacting protein n-terminal like)
D: icln (mus musculus) (ibronectin type iii domain containing 10 like (mus musculus)) (aka ibronectin type iii domain containing 10 like)
E: icln (drosophila melanogaster) (aka icln)
F: picln (drosophila melanogaster) (aka icln)
G: picln (rattus norvegicus) (aka chloride nucleotide-sensitive channel 1a)
H: nucleotide-sensitive chloride conductance regulator (icln) family protein (arabidopsis thaliana) (aka nucleotide-sensitive chloride conductance regulator (icln) family protein)
I: methylosome subunit picln (caenorhabditis elegans) (aka methylosome subunit picln)
J: cttn-like (xenopus tropicalis) (aka hematopoietic cell-specific lyn substrate 1)
K: None of the above. | [B; B] |
<Instruct>: Given the context 'The latter current has been associated with the ICln protein (pICln) which may be the chloride channel itself or, alternatively, a channel regulator.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [icln; picln]
<Options>: A: cystinosin homolog (caenorhabditis elegans) (aka cystinosin homolog)
B: cdkn2a interacting protein n-terminal like (bos taurus) (aka cdkn2a interacting protein n-terminal like)
C: nucleotide-sensitive chloride conductance regulator (icln) family protein (arabidopsis thaliana) (aka nucleotide-sensitive chloride conductance regulator (icln) family protein)
D: cdkn2a interacting protein n-terminal like (xenopus tropicalis) (aka cdkn2a interacting protein n-terminal like)
E: icln (homo sapiens) (chloride nucleotide-sensitive channel 1a (homo sapiens)) (aka chloride nucleotide-sensitive channel 1a)
F: icln-1 (caenorhabditis elegans) (aka methylosome subunit picln)
G: icln (drosophila melanogaster) (aka icln)
H: methylosome subunit picln (caenorhabditis elegans) (aka methylosome subunit picln)
I: pinin-like (xenopus tropicalis) (aka pinin-like)
J: cntln (homo sapiens) (aka centlein)
K: None of the above. | [E; E] |
<Instruct>: Given the context 'We were therefore interested in whether pICln is involved in the endothelial volume-sensitive chloride current.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [picln]
<Options>: A: pinin-like (xenopus tropicalis) (aka pinin-like)
B: cntln (homo sapiens) (aka centlein)
C: cdkn2a interacting protein n-terminal like (xenopus tropicalis) (aka cdkn2a interacting protein n-terminal like)
D: cdkn2a interacting protein n-terminal like (bos taurus) (aka cdkn2a interacting protein n-terminal like)
E: methylosome subunit picln-like (bos taurus) (aka methylosome subunit picln-like)
F: None of the above. | [F] |
<Instruct>: Given the context 'As a first step, we have cloned human pICln and studied its expression at the protein level.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [picln]
<Options>: A: pinin-like (xenopus tropicalis) (aka pinin-like)
B: cntln (homo sapiens) (aka centlein)
C: cdkn2a interacting protein n-terminal like (xenopus tropicalis) (aka cdkn2a interacting protein n-terminal like)
D: picln (drosophila melanogaster) (aka icln)
E: methylosome subunit picln-like (bos taurus) (aka methylosome subunit picln-like)
F: None of the above. | [F] |
<Instruct>: Given the context 'Using a polyclonal antiserum raised against human pICln we found a widespread expression of pICln, both in endothelial cells and in other cell lines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [picln]
<Options>: A: cdkn2a interacting protein n-terminal like (xenopus tropicalis) (aka cdkn2a interacting protein n-terminal like)
B: pinin-like (xenopus tropicalis) (aka pinin-like)
C: cdkn2a interacting protein n-terminal like (bos taurus) (aka cdkn2a interacting protein n-terminal like)
D: cntln (homo sapiens) (aka centlein)
E: methylosome subunit picln-like (bos taurus) (aka methylosome subunit picln-like)
F: None of the above. | [F] |
<Instruct>: Given the context 'A characteristic feature of pICln is its anomalous migration during denaturing polyacrylamide gel electrophoresis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [picln]
<Options>: A: picln (rattus norvegicus) (aka chloride nucleotide-sensitive channel 1a)
B: methylosome subunit picln-like (xenopus laevis) (aka methylosome subunit picln-like)
C: cdkn2a interacting protein n-terminal like (xenopus tropicalis) (aka cdkn2a interacting protein n-terminal like)
D: pinin-like (xenopus tropicalis) (aka pinin-like)
E: methylosome subunit picln (caenorhabditis elegans) (aka methylosome subunit picln)
F: None of the above. | [F] |
<Instruct>: Given the context 'We also demonstrate that bacterially expressed pICln forms homomeric complexes in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [picln]
<Options>: A: cntln (homo sapiens) (aka centlein)
B: cdkn2a interacting protein n-terminal like (xenopus tropicalis) (aka cdkn2a interacting protein n-terminal like)
C: pinin-like (xenopus tropicalis) (aka pinin-like)
D: cdkn2a interacting protein n-terminal like (bos taurus) (aka cdkn2a interacting protein n-terminal like)
E: picln (rattus norvegicus) (aka chloride nucleotide-sensitive channel 1a)
F: None of the above. | [F] |
<Instruct>: Given the context 'Cloning, sequencing and expression of a novel cDNA encoding human vacuolar ATPase (14-kDa subunit).
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vacuolar atpase (14-kda subunit)]
<Options>: A: atp6v0a4 (homo sapiens) (aka atpase h+ transporting v0 subunit a4)
B: atp6s14 (homo sapiens) (aka atpase h+ transporting v1 subunit f)
C: atp14 (saccharomyces cerevisiae s288c) (aka f1f0 atp synthase subunit h)
D: atp6alpha (homo sapiens) (aka activating transcription factor 6)
E: atp6s14-a (xenopus tropicalis) (aka atpase, h+ transporting, lysosomal 14kda, v1 subunit f)
F: None of the above. | [B] |
<Instruct>: Given the context 'A cDNA encoding the 14-kDa subunit of vacuolar ATPase was cloned from human fetal brain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [14-kda subunit of vacuolar atpase]
<Options>: A: atp14 (saccharomyces cerevisiae s288c) (aka f1f0 atp synthase subunit h)
B: atp6a (homo sapiens) (aka atpase h+/k+ transporting subunit alpha)
C: atp14 (candida albicans sc5314) (aka f1f0 atp synthase subunit h)
D: atp1a4 (homo sapiens) (aka atpase na+/k+ transporting subunit alpha 4)
E: atp6s14 (homo sapiens) (aka atpase h+ transporting v1 subunit f)
F: None of the above. | [E] |
<Instruct>: Given the context 'Molecular cloning and functional analysis of a human cDNA encoding an Escherichia coli AlkB homolog, a protein involved in DNA alkylation damage repair.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alkb]
<Options>: A: alk-1 (homo sapiens) (aka activin a receptor like type 1)
B: alkb homolog 2, alpha-ketoglutarate dependent dioxygenase (homo sapiens) (aka alkb homolog 2, alpha-ketoglutarate dependent dioxygenase)
C: alkb homolog 1, histone h2a dioxygenase (mus musculus) (aka alkb homolog 1, histone h2a dioxygenase)
D: alk2 (homo sapiens) (aka activin a receptor type 1)
E: alkb homolog 7 (homo sapiens) (aka alkb homolog 7)
F: None of the above. | [F] |
<Instruct>: Given the context 'The Escherichia coli AlkB protein is involved in protecting cells against mutation and cell death induced specifically by SN2-type alkylating agents such as methyl methanesulfonate (MMS).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alkb]
<Options>: A: alk2 (homo sapiens) (aka activin a receptor type 1)
B: alkb homolog 7 (homo sapiens) (aka alkb homolog 7)
C: alk-1 (homo sapiens) (aka activin a receptor like type 1)
D: alkb homolog 1, histone h2a dioxygenase (homo sapiens) (aka alkb homolog 1, histone h2a dioxygenase)
E: alkb homolog 2, alpha-ketoglutarate dependent dioxygenase (homo sapiens) (aka alkb homolog 2, alpha-ketoglutarate dependent dioxygenase)
F: None of the above. | [F] |
<Instruct>: Given the context 'A human cDNA encoding a polypeptide homologous to E.coli AlkB was discovered by searching a database of expressed sequence tags (ESTs) derived from high throughput cDNA sequencing.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alkb]
<Options>: A: alkb homolog 7 (homo sapiens) (aka alkb homolog 7)
B: alkb homolog 2, alpha-ketoglutarate dependent dioxygenase (homo sapiens) (aka alkb homolog 2, alpha-ketoglutarate dependent dioxygenase)
C: alk2 (homo sapiens) (aka activin a receptor type 1)
D: alkb homolog 1, histone h2a dioxygenase (xenopus tropicalis) (aka alkb homolog 1, histone h2a dioxygenase)
E: alkb homolog 1, histone h2a dioxygenase (mus musculus) (aka alkb homolog 1, histone h2a dioxygenase)
F: None of the above. | [F] |
<Instruct>: Given the context 'The full-length human AlkB homolog (hABH) cDNA clone contains a 924 bp open reading frame encoding a 34 kDa protein which is 52% similar and 23% identical to E.coli AlkB.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alkb; habh]
<Options>: A: alkb homolog 1, histone h2a dioxygenase (xenopus tropicalis) (aka alkb homolog 1, histone h2a dioxygenase)
B: alk-1 (homo sapiens) (aka activin a receptor like type 1)
C: alk2 (homo sapiens) (aka activin a receptor type 1)
D: alkb homolog 7 (homo sapiens) (aka alkb homolog 7)
E: habp (homo sapiens) (aka hyaluronan binding protein 2)
F: hab1 (arabidopsis thaliana) (aka hypersensitive to aba1)
G: alkb (homo sapiens) (aka alkb homolog 1, histone h2a dioxygenase)
H: bcahh (homo sapiens) (aka lysine methyltransferase 2d)
I: habon (homo sapiens) (aka bcl2 interacting protein 3)
J: None of the above. | [G; G] |
<Instruct>: Given the context 'The full-length human AlkB homolog (hABH) cDNA clone contains a 924 bp open reading frame encoding a 34 kDa protein which is 52% similar and 23% identical to E.coli AlkB.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alkb; habh]
<Options>: A: alkb homolog 7 (homo sapiens) (aka alkb homolog 7)
B: alkb homolog 1, histone h2a dioxygenase (homo sapiens) (aka alkb homolog 1, histone h2a dioxygenase)
C: alk receptor tyrosine kinase (homo sapiens) (aka alk receptor tyrosine kinase)
D: alkb homolog 1, histone h2a dioxygenase (xenopus tropicalis) (aka alkb homolog 1, histone h2a dioxygenase)
E: habon (homo sapiens) (aka bcl2 interacting protein 3)
F: hab1 (arabidopsis thaliana) (aka hypersensitive to aba1)
G: habp (homo sapiens) (aka hyaluronan binding protein 2)
H: habp1 (homo sapiens) (aka complement c1q binding protein)
I: alk2 (homo sapiens) (aka activin a receptor type 1)
J: None of the above. | [B; B] |
<Instruct>: Given the context 'The hABH gene, which maps to chromosome 14q24, was ubiquitously expressed in 16 human tissues examined.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [habh]
<Options>: A: abh1 (homo sapiens) (aka alkb homolog 1, histone h2a dioxygenase)
B: habon (homo sapiens) (aka bcl2 interacting protein 3)
C: habp (homo sapiens) (aka hyaluronan binding protein 2)
D: habp1 (homo sapiens) (aka complement c1q binding protein)
E: hab1 (arabidopsis thaliana) (aka hypersensitive to aba1)
F: None of the above. | [A] |
<Instruct>: Given the context 'When hABH was expressed in E.coli alkB mutant cells partial rescue of the cells from MMS-induced cell death occurred.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [habh; alkb]
<Options>: A: hab1 (arabidopsis thaliana) (aka hypersensitive to aba1)
B: alkb homolog 1, histone h2a dioxygenase (homo sapiens) (aka alkb homolog 1, histone h2a dioxygenase)
C: alkb homolog 1, histone h2a dioxygenase (xenopus tropicalis) (aka alkb homolog 1, histone h2a dioxygenase)
D: habp (homo sapiens) (aka hyaluronan binding protein 2)
E: alkb homolog 7 (homo sapiens) (aka alkb homolog 7)
F: habh (homo sapiens) (aka alkb homolog 1, histone h2a dioxygenase)
G: bah (homo sapiens) (aka aspartate beta-hydroxylase)
H: alk2 (homo sapiens) (aka activin a receptor type 1)
I: alk (homo sapiens) (aka alk receptor tyrosine kinase)
J: bcahh (homo sapiens) (aka lysine methyltransferase 2d)
K: None of the above. | [F; K] |
<Instruct>: Given the context 'When hABH was expressed in E.coli alkB mutant cells partial rescue of the cells from MMS-induced cell death occurred.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [habh; alkb]
<Options>: A: abhs (homo sapiens) (aka m-phase specific plk1 interacting protein)
B: hab1 (arabidopsis thaliana) (aka hypersensitive to aba1)
C: alk2 (homo sapiens) (aka activin a receptor type 1)
D: alkb homolog 2, alpha-ketoglutarate dependent dioxygenase (homo sapiens) (aka alkb homolog 2, alpha-ketoglutarate dependent dioxygenase)
E: abh (homo sapiens) (aka alkb homolog 1, histone h2a dioxygenase)
F: alkb homolog 1, histone h2a dioxygenase (homo sapiens) (aka alkb homolog 1, histone h2a dioxygenase)
G: alk (homo sapiens) (aka alk receptor tyrosine kinase)
H: bcahh (homo sapiens) (aka lysine methyltransferase 2d)
I: alkb homolog 7 (homo sapiens) (aka alkb homolog 7)
J: habp1 (homo sapiens) (aka complement c1q binding protein)
K: None of the above. | [E; K] |
<Instruct>: Given the context 'Under the conditions used expression of hABH in skin fibroblasts was not regulated by treatment with MMS.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [habh]
<Options>: A: habp1 (homo sapiens) (aka complement c1q binding protein)
B: habh (homo sapiens) (aka alkb homolog 1, histone h2a dioxygenase)
C: hab1 (arabidopsis thaliana) (aka hypersensitive to aba1)
D: habon (homo sapiens) (aka bcl2 interacting protein 3)
E: bah (homo sapiens) (aka aspartate beta-hydroxylase)
F: None of the above. | [B] |
<Instruct>: Given the context 'Our findings show that the AlkB protein is structurally and functionally conserved from bacteria to human, but its regulation may have diverged during evolution.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alkb]
<Options>: A: alk-1 (homo sapiens) (aka activin a receptor like type 1)
B: alkb homolog 1, histone h2a dioxygenase (mus musculus) (aka alkb homolog 1, histone h2a dioxygenase)
C: alk2 (homo sapiens) (aka activin a receptor type 1)
D: alkb homolog 1, histone h2a dioxygenase (xenopus tropicalis) (aka alkb homolog 1, histone h2a dioxygenase)
E: alkb homolog 2, alpha-ketoglutarate dependent dioxygenase (homo sapiens) (aka alkb homolog 2, alpha-ketoglutarate dependent dioxygenase)
F: None of the above. | [F] |
<Instruct>: Given the context 'Cloning and characterization of human urocortin.
Urocortin, a new member of the CRF peptide family which also includes urotensin I and sauvagine, was recently cloned from the rat midbrain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [urocortin]
<Options>: A: urocortin (oryctolagus cuniculus) (aka urocortin)
B: urocortin (xenopus tropicalis) (aka urocortin)
C: urocortin (sus scrofa) (aka urocortin)
D: urocortin (mus musculus) (aka urocortin)
E: ucn (homo sapiens) (aka urocortin)
F: None of the above. | [E] |
<Instruct>: Given the context 'The synthetic replicate of urocortin was found to bind with high affinity to type 1 and type 2 CRF receptors and, based upon its anatomic localization within the brain, was proposed to be a natural ligand for the type 2 CRF receptors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [urocortin; type 2 crf receptors]
<Options>: A: urocortin (oryctolagus cuniculus) (aka urocortin)
B: crf-r2 (xenopus tropicalis) (aka corticotropin releasing hormone receptor 2)
C: crfr1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
D: ucn (homo sapiens) (aka urocortin)
E: urocortin (xenopus tropicalis) (aka urocortin)
F: urocortin 3 (homo sapiens) (aka urocortin 3)
G: crhr2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
H: corticotropin releasing hormone receptor 2 (rattus norvegicus) (aka corticotropin releasing hormone receptor 2)
I: crf2x (homo sapiens) (aka interleukin 22 receptor subunit alpha 2)
J: urocortin (mus musculus) (aka urocortin)
K: None of the above. | [D; G] |
<Instruct>: Given the context 'The synthetic replicate of urocortin was found to bind with high affinity to type 1 and type 2 CRF receptors and, based upon its anatomic localization within the brain, was proposed to be a natural ligand for the type 2 CRF receptors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [urocortin; type 2 crf receptors]
<Options>: A: crf-r2 (xenopus tropicalis) (aka corticotropin releasing hormone receptor 2)
B: corticotropin releasing hormone receptor 2 (rattus norvegicus) (aka corticotropin releasing hormone receptor 2)
C: urocortin (rattus norvegicus) (aka urocortin)
D: urocortin (xenopus tropicalis) (aka urocortin)
E: urocortin 2 (homo sapiens) (aka urocortin 2)
F: crf2x (homo sapiens) (aka interleukin 22 receptor subunit alpha 2)
G: crfr1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
H: urocortin (bos taurus) (aka urocortin)
I: crhr2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
J: urocortin (homo sapiens) (aka urocortin)
K: None of the above. | [J; I] |
<Instruct>: Given the context 'Using a genomic library, we have cloned the human counterpart of rat urocortin and localized it to human chromosome 2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [urocortin]
<Options>: A: urocortin (mus musculus) (aka urocortin)
B: ucn (homo sapiens) (aka urocortin)
C: urocortin 2 (homo sapiens) (aka urocortin 2)
D: urocortin (oryctolagus cuniculus) (aka urocortin)
E: urocortin (sus scrofa) (aka urocortin)
F: None of the above. | [B] |
<Instruct>: Given the context 'Human and rat urocortin share 95% identity within the mature peptide region.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [urocortin]
<Options>: A: urocortin (oryctolagus cuniculus) (aka urocortin)
B: ucn (homo sapiens) (aka urocortin)
C: urocortin (rattus norvegicus) (aka urocortin)
D: urocortin (mus musculus) (aka urocortin)
E: urocortin 3 (homo sapiens) (aka urocortin 3)
F: None of the above. | [B] |
<Instruct>: Given the context 'Synthetic human urocortin binds with high affinity to CRF receptor types 1, 2 alpha, and 2 beta, stimulates cAMP accumulation from cells stably transfected with these receptors, and acts in vitro to release ACTH from dispersed rat anterior pituitary cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [urocortin; acth]
<Options>: A: urocortin (xenopus tropicalis) (aka urocortin)
B: urocortin 2 (homo sapiens) (aka urocortin 2)
C: urocortin (homo sapiens) (aka urocortin)
D: urocortin (sus scrofa) (aka urocortin)
E: urocortin (rattus norvegicus) (aka urocortin)
F: pomc (homo sapiens) (aka proopiomelanocortin)
G: acth1 (rattus norvegicus) (aka proopiomelanocortin)
H: acthr (homo sapiens) (aka melanocortin 2 receptor)
I: crh (homo sapiens) (aka corticotropin releasing hormone)
J: acth (mus musculus) (aka pro-opiomelanocortin-alpha)
K: None of the above. | [C; F] |
<Instruct>: Given the context 'Synthetic human urocortin binds with high affinity to CRF receptor types 1, 2 alpha, and 2 beta, stimulates cAMP accumulation from cells stably transfected with these receptors, and acts in vitro to release ACTH from dispersed rat anterior pituitary cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [urocortin; acth]
<Options>: A: urocortin (rattus norvegicus) (aka urocortin)
B: proopiomelanocortin (homo sapiens) (aka proopiomelanocortin)
C: acthr (homo sapiens) (aka melanocortin 2 receptor)
D: urocortin (mus musculus) (aka urocortin)
E: corticotropin releasing hormone (homo sapiens) (aka corticotropin releasing hormone)
F: acth1 (rattus norvegicus) (aka proopiomelanocortin)
G: urocortin (oryctolagus cuniculus) (aka urocortin)
H: urocortin (homo sapiens) (aka urocortin)
I: acth (mus musculus) (aka pro-opiomelanocortin-alpha)
J: urocortin (xenopus tropicalis) (aka urocortin)
K: None of the above. | [H; B] |
<Instruct>: Given the context 'In addition, the CRF-binding protein binds human urocortin with high affinity and can prevent urocortin-stimulated ACTH secretion in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [crf-binding protein; urocortin; acth]
<Options>: A: urocortin (mus musculus) (aka urocortin)
B: acth1 (rattus norvegicus) (aka proopiomelanocortin)
C: pro-melanin concentrating hormone (homo sapiens) (aka pro-melanin concentrating hormone)
D: acth (homo sapiens) (aka proopiomelanocortin)
E: urocortin (rattus norvegicus) (aka urocortin)
F: crhbp (rattus norvegicus) (aka corticotropin releasing hormone binding protein)
G: crf-rb (homo sapiens) (aka corticotropin releasing hormone receptor 2)
H: urocortin (bos taurus) (aka urocortin)
I: corticotropin releasing hormone binding protein (bos taurus) (aka corticotropin releasing hormone binding protein)
J: acth (mus musculus) (aka pro-opiomelanocortin-alpha)
K: crf-bp (homo sapiens) (aka corticotropin releasing hormone binding protein)
L: ucn (homo sapiens) (aka urocortin)
M: corticotropin releasing hormone (homo sapiens) (aka corticotropin releasing hormone)
N: urocortin (sus scrofa) (aka urocortin)
O: None of the above. | [K; L; D] |
<Instruct>: Given the context 'In addition, the CRF-binding protein binds human urocortin with high affinity and can prevent urocortin-stimulated ACTH secretion in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [crf-binding protein; urocortin; acth]
<Options>: A: urocortin (xenopus tropicalis) (aka urocortin)
B: crhbp (rattus norvegicus) (aka corticotropin releasing hormone binding protein)
C: urocortin (sus scrofa) (aka urocortin)
D: acth1 (rattus norvegicus) (aka proopiomelanocortin)
E: corticotropin releasing hormone (homo sapiens) (aka corticotropin releasing hormone)
F: acth (homo sapiens) (aka proopiomelanocortin)
G: acth (mus musculus) (aka pro-opiomelanocortin-alpha)
H: crf-rb (homo sapiens) (aka corticotropin releasing hormone receptor 2)
I: pro-melanin concentrating hormone (homo sapiens) (aka pro-melanin concentrating hormone)
J: urocortin 3 (homo sapiens) (aka urocortin 3)
K: urocortin 2 (homo sapiens) (aka urocortin 2)
L: crfbp (homo sapiens) (aka corticotropin releasing hormone binding protein)
M: ucn (homo sapiens) (aka urocortin)
N: corticotropin releasing hormone binding protein (bos taurus) (aka corticotropin releasing hormone binding protein)
O: None of the above. | [L; M; F] |
<Instruct>: Given the context 'In addition, the CRF-binding protein binds human urocortin with high affinity and can prevent urocortin-stimulated ACTH secretion in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [crf-binding protein; urocortin; acth]
<Options>: A: urocortin (mus musculus) (aka urocortin)
B: corticotropin releasing hormone binding protein (bos taurus) (aka corticotropin releasing hormone binding protein)
C: urocortin (xenopus tropicalis) (aka urocortin)
D: acthr (homo sapiens) (aka melanocortin 2 receptor)
E: acth (mus musculus) (aka pro-opiomelanocortin-alpha)
F: acth (homo sapiens) (aka proopiomelanocortin)
G: crhbp (homo sapiens) (aka corticotropin releasing hormone binding protein)
H: pro-melanin concentrating hormone (homo sapiens) (aka pro-melanin concentrating hormone)
I: crhbp (rattus norvegicus) (aka corticotropin releasing hormone binding protein)
J: urocortin 3 (homo sapiens) (aka urocortin 3)
K: urocortin (homo sapiens) (aka urocortin)
L: urocortin 2 (homo sapiens) (aka urocortin 2)
M: crf-rb (homo sapiens) (aka corticotropin releasing hormone receptor 2)
N: acth1 (rattus norvegicus) (aka proopiomelanocortin)
O: None of the above. | [G; K; F] |
<Instruct>: Given the context 'In addition, the CRF-binding protein binds human urocortin with high affinity and can prevent urocortin-stimulated ACTH secretion in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [crf-binding protein; urocortin; acth]
<Options>: A: urocortin 2 (homo sapiens) (aka urocortin 2)
B: urocortin 3 (homo sapiens) (aka urocortin 3)
C: urocortin (homo sapiens) (aka urocortin)
D: crf-rb (homo sapiens) (aka corticotropin releasing hormone receptor 2)
E: pro-melanin concentrating hormone (homo sapiens) (aka pro-melanin concentrating hormone)
F: urocortin (mus musculus) (aka urocortin)
G: crhbp (rattus norvegicus) (aka corticotropin releasing hormone binding protein)
H: urocortin (xenopus tropicalis) (aka urocortin)
I: acth (mus musculus) (aka pro-opiomelanocortin-alpha)
J: crhbp (homo sapiens) (aka corticotropin releasing hormone binding protein)
K: corticotropin releasing hormone binding protein (bos taurus) (aka corticotropin releasing hormone binding protein)
L: acthr (homo sapiens) (aka melanocortin 2 receptor)
M: acth1 (rattus norvegicus) (aka proopiomelanocortin)
N: None of the above. | [J; C; N] |
<Instruct>: Given the context 'The inhibitory effect of the CRF-binding protein on human urocortin can be blocked by biologically inactive CRF fragments, such as CRF(9-33).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [crf-binding protein; urocortin; crf]
<Options>: A: hm-crf (homo sapiens) (aka corticotropin releasing hormone receptor 2)
B: corticotropin releasing hormone (rattus norvegicus) (aka corticotropin releasing hormone)
C: urocortin (xenopus tropicalis) (aka urocortin)
D: urocortin (rattus norvegicus) (aka urocortin)
E: crhbp (rattus norvegicus) (aka corticotropin releasing hormone binding protein)
F: crf (homo sapiens) (aka complement c1q like 1)
G: urocortin 3 (homo sapiens) (aka urocortin 3)
H: urocortin (homo sapiens) (aka urocortin)
I: crfbp (homo sapiens) (aka corticotropin releasing hormone binding protein)
J: corticotropin releasing hormone binding protein (bos taurus) (aka corticotropin releasing hormone binding protein)
K: crf-rb (homo sapiens) (aka corticotropin releasing hormone receptor 2)
L: crf-r-1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
M: urocortin 2 (homo sapiens) (aka urocortin 2)
N: corticotropin releasing hormone (homo sapiens) (aka corticotropin releasing hormone)
O: None of the above. | [I; H; N] |
<Instruct>: Given the context 'The inhibitory effect of the CRF-binding protein on human urocortin can be blocked by biologically inactive CRF fragments, such as CRF(9-33).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [crf-binding protein; urocortin; crf]
<Options>: A: hm-crf (homo sapiens) (aka corticotropin releasing hormone receptor 2)
B: crf-rb (homo sapiens) (aka corticotropin releasing hormone receptor 2)
C: urocortin (sus scrofa) (aka urocortin)
D: crhbp (homo sapiens) (aka corticotropin releasing hormone binding protein)
E: urocortin (bos taurus) (aka urocortin)
F: ucn (homo sapiens) (aka urocortin)
G: corticotropin releasing hormone (rattus norvegicus) (aka corticotropin releasing hormone)
H: corticotropin releasing hormone (homo sapiens) (aka corticotropin releasing hormone)
I: crf-r-1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
J: crf (homo sapiens) (aka complement c1q like 1)
K: urocortin 2 (homo sapiens) (aka urocortin 2)
L: crhbp (bos taurus) (aka corticotropin releasing hormone binding protein)
M: corticotropin releasing hormone binding protein (rattus norvegicus) (aka corticotropin releasing hormone binding protein)
N: urocortin 3 (homo sapiens) (aka urocortin 3)
O: None of the above. | [D; F; H] |
<Instruct>: Given the context 'The inhibitory effect of the CRF-binding protein on human urocortin can be blocked by biologically inactive CRF fragments, such as CRF(9-33).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [crf-binding protein; urocortin; crf]
<Options>: A: crhbp (bos taurus) (aka corticotropin releasing hormone binding protein)
B: ucn (homo sapiens) (aka urocortin)
C: hm-crf (homo sapiens) (aka corticotropin releasing hormone receptor 2)
D: corticotropin releasing hormone (rattus norvegicus) (aka corticotropin releasing hormone)
E: crfbp (homo sapiens) (aka corticotropin releasing hormone binding protein)
F: urocortin (bos taurus) (aka urocortin)
G: crf-rb (homo sapiens) (aka corticotropin releasing hormone receptor 2)
H: urocortin (xenopus tropicalis) (aka urocortin)
I: corticotropin releasing hormone (homo sapiens) (aka corticotropin releasing hormone)
J: crf (homo sapiens) (aka complement c1q like 1)
K: crhbp (rattus norvegicus) (aka corticotropin releasing hormone binding protein)
L: urocortin (mus musculus) (aka urocortin)
M: urocortin (rattus norvegicus) (aka urocortin)
N: crfr-1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
O: None of the above. | [E; B; I] |
<Instruct>: Given the context 'Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [brain-specific na(+)-dependent inorganic phosphate cotransporter]
<Options>: A: solute carrier family 16 member 2 (homo sapiens) (aka solute carrier family 16 member 2)
B: npt2 (homo sapiens) (aka solute carrier family 34 member 1)
C: inorganic phosphate transporter 1-2 (glycine max) (aka inorganic phosphate transporter 1-2)
D: na[+]-dependent inorganic phosphate cotransporter (drosophila melanogaster) (aka na[+]-dependent inorganic phosphate cotransporter)
E: vglut1 (homo sapiens) (aka solute carrier family 17 member 7)
F: None of the above. | [E] |
<Instruct>: Given the context 'Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [brain-specific na(+)-dependent inorganic phosphate cotransporter]
<Options>: A: npt2 (homo sapiens) (aka solute carrier family 34 member 1)
B: solute carrier family 16 member 2 (homo sapiens) (aka solute carrier family 16 member 2)
C: na[+]-dependent inorganic phosphate cotransporter (drosophila melanogaster) (aka na[+]-dependent inorganic phosphate cotransporter)
D: inorganic phosphate transporter 1-2 (glycine max) (aka inorganic phosphate transporter 1-2)
E: None of the above. | [E] |
<Instruct>: Given the context 'We describe the molecular cloning of a cDNA encoding a human brain Na(+)-dependent inorganic phosphate (P(i)) cotransporter (hBNPI).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [brain na(+)-dependent inorganic phosphate (p(i)) cotransporter; hbnpi]
<Options>: A: nprbi (homo sapiens) (aka natriuretic peptide receptor 2)
B: na[+]-dependent inorganic phosphate cotransporter (drosophila melanogaster) (aka na[+]-dependent inorganic phosphate cotransporter)
C: npipb1p (homo sapiens) (aka nuclear pore complex interacting protein family member b1, pseudogene)
D: npb (homo sapiens) (aka neuropeptide b)
E: vglut1 (homo sapiens) (aka solute carrier family 17 member 7)
F: inorganic phosphate transporter 1-1 (glycine max) (aka inorganic phosphate transporter 1-1)
G: inorganic phosphate transporter 1-2 (glycine max) (aka inorganic phosphate transporter 1-2)
H: pnpi (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 2)
I: npt1 (homo sapiens) (aka solute carrier family 17 member 1)
J: None of the above. | [E; E] |
<Instruct>: Given the context 'We describe the molecular cloning of a cDNA encoding a human brain Na(+)-dependent inorganic phosphate (P(i)) cotransporter (hBNPI).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [brain na(+)-dependent inorganic phosphate (p(i)) cotransporter; hbnpi]
<Options>: A: hbi (homo sapiens) (aka fkbp prolyl isomerase 4)
B: nbat-1 (homo sapiens) (aka neuroblastoma associated transcript 1)
C: vglut1 (homo sapiens) (aka solute carrier family 17 member 7)
D: npipb1p (homo sapiens) (aka nuclear pore complex interacting protein family member b1, pseudogene)
E: inorganic phosphate transporter 1-1 (glycine max) (aka inorganic phosphate transporter 1-1)
F: nppb (homo sapiens) (aka natriuretic peptide b)
G: vglut3 (homo sapiens) (aka solute carrier family 17 member 8)
H: vglut2 (homo sapiens) (aka solute carrier family 17 member 6)
I: nprbi (homo sapiens) (aka natriuretic peptide receptor 2)
J: None of the above. | [C; C] |
<Instruct>: Given the context 'The nucleotide and deduced amino acid sequences of hBNPI reveal a protein of 560 amino acids with six to eight putative transmembrane segments.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hbnpi]
<Options>: A: nppb (homo sapiens) (aka natriuretic peptide b)
B: hbi (homo sapiens) (aka fkbp prolyl isomerase 4)
C: nprbi (homo sapiens) (aka natriuretic peptide receptor 2)
D: npb (homo sapiens) (aka neuropeptide b)
E: bnpi (homo sapiens) (aka solute carrier family 17 member 7)
F: None of the above. | [E] |
<Instruct>: Given the context 'hBNPI shares a high degree of homology with other Na(+)-dependent inorganic P(i) cotransporters, including those found in rat brain and human and rabbit kidney.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hbnpi]
<Options>: A: pni (homo sapiens) (aka serpin family e member 2)
B: npipb1p (homo sapiens) (aka nuclear pore complex interacting protein family member b1, pseudogene)
C: hbi (homo sapiens) (aka fkbp prolyl isomerase 4)
D: bnpi (homo sapiens) (aka solute carrier family 17 member 7)
E: npb (homo sapiens) (aka neuropeptide b)
F: None of the above. | [D] |
<Instruct>: Given the context 'Expression of hBNPI in COS-1 cells results in Na(+)-dependent P(i) uptake.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hbnpi]
<Options>: A: nppb (homo sapiens) (aka natriuretic peptide b)
B: bnpi (homo sapiens) (aka solute carrier family 17 member 7)
C: hbi (homo sapiens) (aka fkbp prolyl isomerase 4)
D: npb (homo sapiens) (aka neuropeptide b)
E: npi (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 2)
F: None of the above. | [B] |
<Instruct>: Given the context 'Northern blot analysis demonstrates that hBNPI mRNA is expressed predominantly in brain and most abundantly in neuron-enriched regions such as the amygdala and hippocampus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hbnpi]
<Options>: A: pnpi (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 2)
B: npb (homo sapiens) (aka neuropeptide b)
C: nprbi (homo sapiens) (aka natriuretic peptide receptor 2)
D: bnpi (homo sapiens) (aka solute carrier family 17 member 7)
E: nppb (homo sapiens) (aka natriuretic peptide b)
F: None of the above. | [D] |
<Instruct>: Given the context 'In situ hybridization histochemistry reveals relatively high levels of hBNPI mRNA in pyramidal neurons of the cerebral cortex and hippocampus and in granule neurons of dentate gyrus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hbnpi]
<Options>: A: pnpi (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 2)
B: npipb1p (homo sapiens) (aka nuclear pore complex interacting protein family member b1, pseudogene)
C: bnpi (homo sapiens) (aka solute carrier family 17 member 7)
D: nprbi (homo sapiens) (aka natriuretic peptide receptor 2)
E: impnb (homo sapiens) (aka karyopherin subunit beta 1)
F: None of the above. | [C] |
<Instruct>: Given the context 'The level of hBNPI mRNA is quite low in fetal compared with adult human brain, suggesting developmental regulation of hBNPI gene expression.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hbnpi]
<Options>: A: bnpi (homo sapiens) (aka solute carrier family 17 member 7)
B: npipb1p (homo sapiens) (aka nuclear pore complex interacting protein family member b1, pseudogene)
C: pni (homo sapiens) (aka serpin family e member 2)
D: npb (homo sapiens) (aka neuropeptide b)
E: hbi (homo sapiens) (aka fkbp prolyl isomerase 4)
F: None of the above. | [A] |
<Instruct>: Given the context 'The level of hBNPI mRNA is quite low in fetal compared with adult human brain, suggesting developmental regulation of hBNPI gene expression.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hbnpi]
<Options>: A: hbi (homo sapiens) (aka fkbp prolyl isomerase 4)
B: pni (homo sapiens) (aka serpin family e member 2)
C: npb (homo sapiens) (aka neuropeptide b)
D: npipb1p (homo sapiens) (aka nuclear pore complex interacting protein family member b1, pseudogene)
E: None of the above. | [E] |
<Instruct>: Given the context 'Southern analyses of nine eukaryotic genomic DNAs probed under stringent conditions with hBNPI cDNA revealed that the hBNPI gene is highly conserved during vertebrate evolution and that each gene is most likely present as a single copy.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hbnpi]
<Options>: A: nprbi (homo sapiens) (aka natriuretic peptide receptor 2)
B: npipb1p (homo sapiens) (aka nuclear pore complex interacting protein family member b1, pseudogene)
C: hbi (homo sapiens) (aka fkbp prolyl isomerase 4)
D: npb (homo sapiens) (aka neuropeptide b)
E: bnpi (homo sapiens) (aka solute carrier family 17 member 7)
F: None of the above. | [E] |
<Instruct>: Given the context 'Using fluorescent in situ hybridization, we localized hBNPI to the long arm of chromosome 19 (19q13) in close proximity to the late-onset familial Alzheimer's disease locus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hbnpi]
<Options>: A: pni (homo sapiens) (aka serpin family e member 2)
B: nppb (homo sapiens) (aka natriuretic peptide b)
C: impnb (homo sapiens) (aka karyopherin subunit beta 1)
D: npi (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 2)
E: bnpi (homo sapiens) (aka solute carrier family 17 member 7)
F: None of the above. | [E] |
<Instruct>: Given the context 'In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase.
Rab8 is a small GTP-binding protein that plays a role in vesicular transport from the trans-Golgi network to the basolateral plasma membrane in polarized epithelial cells (MDCK), and to the dendritic surface in hippocampal neurons.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rab8]
<Options>: A: rab8a, member ras oncogene family l homeolog (xenopus laevis) (aka rab8a, member ras oncogene family l homeolog)
B: rab8a, member ras oncogene family (mus musculus) (aka rab8a, member ras oncogene family)
C: rab28, member ras oncogene family (homo sapiens) (aka rab28, member ras oncogene family)
D: rab8a, member ras oncogene family (homo sapiens) (aka rab8a, member ras oncogene family)
E: rab8b, member ras oncogene family (homo sapiens) (aka rab8b, member ras oncogene family)
F: None of the above. | [D] |
<Instruct>: Given the context 'As is the case for most other rab proteins, the precise molecular interactions by which rab8 carries out its function remain to be elucidated.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rab8]
<Options>: A: rab8a, member ras oncogene family l homeolog (xenopus laevis) (aka rab8a, member ras oncogene family l homeolog)
B: rab8a, member ras oncogene family (mus musculus) (aka rab8a, member ras oncogene family)
C: rab8 (drosophila melanogaster) (aka rab8)
D: rabin8 (homo sapiens) (aka rab3a interacting protein)
E: rab8a (homo sapiens) (aka rab8a, member ras oncogene family)
F: None of the above. | [E] |
<Instruct>: Given the context 'Here we report the identification and the complete cDNA-derived amino acid sequence of a murine rab8-interacting protein (rab8ip) that specifically interacts with rab8 in a GTP-dependent manner.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rab8-interacting protein; rab8ip; rab8]
<Options>: A: rab3a interacting protein (homo sapiens) (aka rab3a interacting protein)
B: rab3a interacting protein (xenopus tropicalis) (aka rab3a interacting protein)
C: rab8a, member ras oncogene family (mus musculus) (aka rab8a, member ras oncogene family)
D: rab8a, member ras oncogene family l homeolog (xenopus laevis) (aka rab8a, member ras oncogene family l homeolog)
E: rab8ip (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 2)
F: rab8 (drosophila melanogaster) (aka rab8)
G: rab8ip (mus musculus) (aka mitogen-activated protein kinase kinase kinase kinase 2)
H: rab8a, member ras oncogene family (homo sapiens) (aka rab8a, member ras oncogene family)
I: rab6ip1 (homo sapiens) (aka denn domain containing 5a)
J: prkm8ip (homo sapiens) (aka mitogen-activated protein kinase 8 interacting protein 1)
K: rab5ip (homo sapiens) (aka sad1 and unc84 domain containing 2)
L: rab28, member ras oncogene family (homo sapiens) (aka rab28, member ras oncogene family)
M: mcm8ip (homo sapiens) (aka homologous recombination factor with ob-fold)
N: None of the above. | [G; G; H] |
<Instruct>: Given the context 'Here we report the identification and the complete cDNA-derived amino acid sequence of a murine rab8-interacting protein (rab8ip) that specifically interacts with rab8 in a GTP-dependent manner.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rab8-interacting protein; rab8ip; rab8]
<Options>: A: prkm8ip (homo sapiens) (aka mitogen-activated protein kinase 8 interacting protein 1)
B: rab6ip1 (homo sapiens) (aka denn domain containing 5a)
C: rab8ipl1 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 3)
D: mel (homo sapiens) (rab8a, member ras oncogene family (homo sapiens)) (aka rab8a, member ras oncogene family)
E: rab8ip (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 2)
F: rab8a, member ras oncogene family (mus musculus) (aka rab8a, member ras oncogene family)
G: rab8b, member ras oncogene family (homo sapiens) (aka rab8b, member ras oncogene family)
H: rab5ip (homo sapiens) (aka sad1 and unc84 domain containing 2)
I: rab8ip (mus musculus) (aka mitogen-activated protein kinase kinase kinase kinase 2)
J: rabin8 (homo sapiens) (aka rab3a interacting protein)
K: rab8a, member ras oncogene family l homeolog (xenopus laevis) (aka rab8a, member ras oncogene family l homeolog)
L: None of the above. | [I; I; D] |
<Instruct>: Given the context 'Here we report the identification and the complete cDNA-derived amino acid sequence of a murine rab8-interacting protein (rab8ip) that specifically interacts with rab8 in a GTP-dependent manner.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rab8-interacting protein; rab8ip; rab8]
<Options>: A: rab8a, member ras oncogene family l homeolog (xenopus laevis) (aka rab8a, member ras oncogene family l homeolog)
B: rabin8 (homo sapiens) (aka rab3a interacting protein)
C: rab6ip1 (homo sapiens) (aka denn domain containing 5a)
D: prkm8ip (homo sapiens) (aka mitogen-activated protein kinase 8 interacting protein 1)
E: rab8a, member ras oncogene family (mus musculus) (aka rab8a, member ras oncogene family)
F: rab8b, member ras oncogene family (homo sapiens) (aka rab8b, member ras oncogene family)
G: rab5ip (homo sapiens) (aka sad1 and unc84 domain containing 2)
H: rab8ip (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 2)
I: rab8ip (mus musculus) (aka mitogen-activated protein kinase kinase kinase kinase 2)
J: rab8ipl1 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 3)
K: None of the above. | [I; I; K] |
<Instruct>: Given the context 'Here we report the identification and the complete cDNA-derived amino acid sequence of a murine rab8-interacting protein (rab8ip) that specifically interacts with rab8 in a GTP-dependent manner.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rab8-interacting protein; rab8ip; rab8]
<Options>: A: rab6ip1 (homo sapiens) (aka denn domain containing 5a)
B: rab8a (homo sapiens) (aka rab8a, member ras oncogene family)
C: rab8a, member ras oncogene family (homo sapiens) (aka rab8a, member ras oncogene family)
D: rab28, member ras oncogene family (homo sapiens) (aka rab28, member ras oncogene family)
E: rab8ipl1 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 3)
F: rab8 (drosophila melanogaster) (aka rab8)
G: rab8a, member ras oncogene family l homeolog (xenopus laevis) (aka rab8a, member ras oncogene family l homeolog)
H: rab8b, member ras oncogene family (homo sapiens) (aka rab8b, member ras oncogene family)
I: prkm8ip (homo sapiens) (aka mitogen-activated protein kinase 8 interacting protein 1)
J: rab8ip (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 2)
K: rabin8 (homo sapiens) (aka rab3a interacting protein)
L: rab8ip (mus musculus) (aka mitogen-activated protein kinase kinase kinase kinase 2)
M: None of the above. | [L; L; C] |
<Instruct>: Given the context 'Rab8ip displays 93% identity with the GC kinase, a serine/threonine protein kinase recently identified in human lymphoid tissue that is activated in the stress response.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rab8ip; gc kinase]
<Options>: A: gck (homo sapiens) (mitogen-activated protein kinase kinase kinase kinase 2 (homo sapiens)) (aka mitogen-activated protein kinase kinase kinase kinase 2)
B: rab8ip (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 2)
C: rab8ip (mus musculus) (aka mitogen-activated protein kinase kinase kinase kinase 2)
D: rab6ip1 (homo sapiens) (aka denn domain containing 5a)
E: gck-a (xenopus laevis) (aka glucokinase (hexokinase 4) l homeolog)
F: prkm8ip (homo sapiens) (aka mitogen-activated protein kinase 8 interacting protein 1)
G: gck-1 (caenorhabditis elegans) (aka germinal center kinase 1;non-specific serine/threonine protein kinase)
H: gck (homo sapiens) (glucokinase (homo sapiens)) (aka glucokinase)
I: gck (xenopus tropicalis) (aka glucokinase (hexokinase 4))
J: mcm8ip (homo sapiens) (aka homologous recombination factor with ob-fold)
K: None of the above. | [C; A] |
<Instruct>: Given the context 'Rab8ip displays 93% identity with the GC kinase, a serine/threonine protein kinase recently identified in human lymphoid tissue that is activated in the stress response.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rab8ip; gc kinase]
<Options>: A: gck-1 (caenorhabditis elegans) (aka germinal center kinase 1;non-specific serine/threonine protein kinase)
B: rab5ip (homo sapiens) (aka sad1 and unc84 domain containing 2)
C: rabin8 (homo sapiens) (aka rab3a interacting protein)
D: rab6ip1 (homo sapiens) (aka denn domain containing 5a)
E: prkm8ip (homo sapiens) (aka mitogen-activated protein kinase 8 interacting protein 1)
F: gck (xenopus tropicalis) (aka glucokinase (hexokinase 4))
G: rab8ip (mus musculus) (aka mitogen-activated protein kinase kinase kinase kinase 2)
H: gck-a (xenopus laevis) (aka glucokinase (hexokinase 4) l homeolog)
I: gnk (homo sapiens) (aka n-acetylglucosamine kinase)
J: gck (homo sapiens) (mitogen-activated protein kinase kinase kinase kinase 2 (homo sapiens)) (aka mitogen-activated protein kinase kinase kinase kinase 2)
K: None of the above. | [G; J] |
<Instruct>: Given the context 'Like the GC kinase, rab8ip has protein kinase activity manifested by autophosphorylation and phosphorylation of the classical serine/threonine protein kinase substrates, myelin basic protein and casein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gc kinase; rab8ip; myelin basic protein]
<Options>: A: rab8ip (mus musculus) (aka mitogen-activated protein kinase kinase kinase kinase 2)
B: rab8ipl1 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 3)
C: rab6ip1 (homo sapiens) (aka denn domain containing 5a)
D: myelin basic protein (bos taurus) (aka myelin basic protein)
E: gck (homo sapiens) (mitogen-activated protein kinase kinase kinase kinase 2 (homo sapiens)) (aka mitogen-activated protein kinase kinase kinase kinase 2)
F: gck (homo sapiens) (glucokinase (homo sapiens)) (aka glucokinase)
G: myelin associated oligodendrocyte basic protein (homo sapiens) (aka myelin associated oligodendrocyte basic protein)
H: gck (xenopus tropicalis) (aka glucokinase (hexokinase 4))
I: mcm8ip (homo sapiens) (aka homologous recombination factor with ob-fold)
J: myelin-associated oligodendrocytic basic protein (mus musculus) (aka myelin-associated oligodendrocytic basic protein)
K: mbp (mus musculus) (myelin basic protein (mus musculus)) (aka myelin basic protein)
L: prkm8ip (homo sapiens) (aka mitogen-activated protein kinase 8 interacting protein 1)
M: mbp (homo sapiens) (myelin basic protein (homo sapiens)) (aka myelin basic protein)
N: gck-2 (caenorhabditis elegans) (aka mitogen-activated protein kinase kinase kinase kinase)
O: gnk (homo sapiens) (aka n-acetylglucosamine kinase)
P: None of the above. | [E; A; M] |
<Instruct>: Given the context 'Like the GC kinase, rab8ip has protein kinase activity manifested by autophosphorylation and phosphorylation of the classical serine/threonine protein kinase substrates, myelin basic protein and casein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gc kinase; rab8ip; myelin basic protein]
<Options>: A: gnk (homo sapiens) (aka n-acetylglucosamine kinase)
B: myelin-associated oligodendrocytic basic protein (mus musculus) (aka myelin-associated oligodendrocytic basic protein)
C: gck (homo sapiens) (mitogen-activated protein kinase kinase kinase kinase 2 (homo sapiens)) (aka mitogen-activated protein kinase kinase kinase kinase 2)
D: myelin basic protein (bos taurus) (aka myelin basic protein)
E: rab8ipl1 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 3)
F: rab6ip1 (homo sapiens) (aka denn domain containing 5a)
G: mbp (mus musculus) (myelin basic protein (mus musculus)) (aka myelin basic protein)
H: gck (homo sapiens) (glucokinase (homo sapiens)) (aka glucokinase)
I: prkm8ip (homo sapiens) (aka mitogen-activated protein kinase 8 interacting protein 1)
J: mbp (homo sapiens) (myelin basic protein (homo sapiens)) (aka myelin basic protein)
K: myelin associated oligodendrocyte basic protein (homo sapiens) (aka myelin associated oligodendrocyte basic protein)
L: gck (xenopus tropicalis) (aka glucokinase (hexokinase 4))
M: gck-2 (caenorhabditis elegans) (aka mitogen-activated protein kinase kinase kinase kinase)
N: mcm8ip (homo sapiens) (aka homologous recombination factor with ob-fold)
O: None of the above. | [C; O; J] |
<Instruct>: Given the context 'Like the GC kinase, rab8ip has protein kinase activity manifested by autophosphorylation and phosphorylation of the classical serine/threonine protein kinase substrates, myelin basic protein and casein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gc kinase; rab8ip; myelin basic protein]
<Options>: A: mbp (homo sapiens) (myelin basic protein (homo sapiens)) (aka myelin basic protein)
B: rab5ip (homo sapiens) (aka sad1 and unc84 domain containing 2)
C: rab8ip (mus musculus) (aka mitogen-activated protein kinase kinase kinase kinase 2)
D: myelin basic protein (xenopus tropicalis) (aka myelin basic protein)
E: myelin basic protein (mus musculus) (aka myelin basic protein)
F: rab6ip1 (homo sapiens) (aka denn domain containing 5a)
G: prkm8ip (homo sapiens) (aka mitogen-activated protein kinase 8 interacting protein 1)
H: gck (xenopus laevis) (aka glucokinase (hexokinase 4) l homeolog)
I: rab8ip (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 2)
J: gnk (homo sapiens) (aka n-acetylglucosamine kinase)
K: gck (homo sapiens) (mitogen-activated protein kinase kinase kinase kinase 2 (homo sapiens)) (aka mitogen-activated protein kinase kinase kinase kinase 2)
L: myelin-associated oligodendrocytic basic protein (mus musculus) (aka myelin-associated oligodendrocytic basic protein)
M: gck (homo sapiens) (glucokinase (homo sapiens)) (aka glucokinase)
N: gck-1 (caenorhabditis elegans) (aka germinal center kinase 1;non-specific serine/threonine protein kinase)
O: myelin basic protein (bos taurus) (aka myelin basic protein)
P: None of the above. | [K; C; A] |
<Instruct>: Given the context 'Like the GC kinase, rab8ip has protein kinase activity manifested by autophosphorylation and phosphorylation of the classical serine/threonine protein kinase substrates, myelin basic protein and casein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gc kinase; rab8ip; myelin basic protein]
<Options>: A: gck (xenopus laevis) (aka glucokinase (hexokinase 4) l homeolog)
B: prkm8ip (homo sapiens) (aka mitogen-activated protein kinase 8 interacting protein 1)
C: rab6ip1 (homo sapiens) (aka denn domain containing 5a)
D: gck (homo sapiens) (mitogen-activated protein kinase kinase kinase kinase 2 (homo sapiens)) (aka mitogen-activated protein kinase kinase kinase kinase 2)
E: myelin basic protein (xenopus tropicalis) (aka myelin basic protein)
F: rab8ip (mus musculus) (aka mitogen-activated protein kinase kinase kinase kinase 2)
G: gck-2 (caenorhabditis elegans) (aka mitogen-activated protein kinase kinase kinase kinase)
H: myelin associated oligodendrocyte basic protein (homo sapiens) (aka myelin associated oligodendrocyte basic protein)
I: gck-1 (caenorhabditis elegans) (aka germinal center kinase 1;non-specific serine/threonine protein kinase)
J: rab8ipl1 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 3)
K: myelin basic protein (rattus norvegicus) (aka myelin basic protein)
L: rab3a interacting protein (homo sapiens) (aka rab3a interacting protein)
M: mbp (mus musculus) (myelin basic protein (mus musculus)) (aka myelin basic protein)
N: myelin basic protein (homo sapiens) (aka myelin basic protein)
O: gck (homo sapiens) (glucokinase (homo sapiens)) (aka glucokinase)
P: None of the above. | [D; F; N] |
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