instruction stringlengths 207 1.11k | input stringlengths 157 2.59k | response stringlengths 3 12 |
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<Instruct>: Given the context 'ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8alpha(+) dendritic cells.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for eac... | <Mentions>: [icsbp; type i interferon; cd8alpha]
<Options>: A: icsbp1 (rattus norvegicus) (aka interferon regulatory factor 8)
B: cd8a (rattus norvegicus) (aka cd8 subunit alpha)
C: interferon, alpha 1 (rattus norvegicus) (aka interferon, alpha 1)
D: cd8 subunit alpha (mus musculus) (aka cd8 subunit alpha)
E: ifnb1 (ho... | [G; O; D] |
<Instruct>: Given the context 'ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8alpha(+) dendritic cells.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for eac... | <Mentions>: [icsbp; type i interferon; cd8alpha]
<Options>: A: icsbp1 (rattus norvegicus) (aka interferon regulatory factor 8)
B: h-icsbp (homo sapiens) (aka interferon regulatory factor 8)
C: cd8a (rattus norvegicus) (aka cd8 subunit alpha)
D: icsbp (mus musculus) (aka interferon regulatory factor 8)
E: interferon, ty... | [D; K; O] |
<Instruct>: Given the context 'ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8alpha(+) dendritic cells.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for eac... | <Mentions>: [icsbp; type i interferon; cd8alpha]
<Options>: A: icsbp1 (mus musculus) (aka interferon regulatory factor 8)
B: interferon alpha 1 (mus musculus) (aka interferon alpha 1)
C: ifnb1 (homo sapiens) (aka interferon beta 1)
D: ilbp (mus musculus) (aka fatty acid binding protein 6)
E: cd8a (rattus norvegicus) (a... | [A; N; H] |
<Instruct>: Given the context 'Interferon (IFN) consensus sequence-binding protein (ICSBP) is a transcription factor playing a critical role in the regulation of lineage commitment, especially in myeloid cell differentiation.', select the correct biomedical concept for each mention using the provided options. In the an... | <Mentions>: [interferon (ifn) consensus sequence-binding protein; icsbp; transcription factor]
<Options>: A: icsbp (rattus norvegicus) (aka interferon regulatory factor 8)
B: tcf1 (homo sapiens) (aka hnf1 homeobox a)
C: sine oculis binding protein (mus musculus) (aka sine oculis binding protein)
D: ilbp (mus musculus) ... | [L; L; O] |
<Instruct>: Given the context 'Interferon (IFN) consensus sequence-binding protein (ICSBP) is a transcription factor playing a critical role in the regulation of lineage commitment, especially in myeloid cell differentiation.', select the correct biomedical concept for each mention using the provided options. In the an... | <Mentions>: [interferon (ifn) consensus sequence-binding protein; icsbp; transcription factor]
<Options>: A: trans-acting transcription factor 1 (mus musculus) (aka trans-acting transcription factor 1)
B: ns1bp (homo sapiens) (aka influenza virus ns1a binding protein)
C: icsbp1 (homo sapiens) (aka interferon regulatory... | [L; L; M] |
<Instruct>: Given the context 'Interferon (IFN) consensus sequence-binding protein (ICSBP) is a transcription factor playing a critical role in the regulation of lineage commitment, especially in myeloid cell differentiation.', select the correct biomedical concept for each mention using the provided options. In the an... | <Mentions>: [interferon (ifn) consensus sequence-binding protein; icsbp; transcription factor]
<Options>: A: icsbp (rattus norvegicus) (aka interferon regulatory factor 8)
B: ilbp (homo sapiens) (aka fatty acid binding protein 6)
C: icsbp1 (rattus norvegicus) (aka interferon regulatory factor 8)
D: icsbp1 (mus musculus... | [N; D; P] |
<Instruct>: Given the context 'In this study, we have characterized the phenotype and activation pattern of subsets of dendritic cells (DCs) in ICSBP(-/-) mice.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated b... | <Mentions>: [icsbp]
<Options>: A: ilbp (homo sapiens) (aka fatty acid binding protein 6)
B: icsbp1 (homo sapiens) (aka interferon regulatory factor 8)
C: icsbp1 (mus musculus) (aka interferon regulatory factor 8)
D: icsbp1 (rattus norvegicus) (aka interferon regulatory factor 8)
E: ilbp (mus musculus) (aka fatty acid b... | [C] |
<Instruct>: Given the context 'Remarkably, the recently identified mouse IFN-producing cells (mIPCs) were absent in all lymphoid organs from ICSBP(-/-) mice, as revealed by lack of CD11c(low)B220(+)Ly6C(+)CD11b(-) cells.', select the correct biomedical concept for each mention using the provided options. In the answer,... | <Mentions>: [ifn; icsbp; cd11c; b220]
<Options>: A: ilbp (mus musculus) (aka fatty acid binding protein 6)
B: cd20 (mus musculus) (aka membrane-spanning 4-domains, subfamily a, member 1)
C: cd79a (mus musculus) (aka cd79a antigen (immunoglobulin-associated alpha))
D: cd64 (mus musculus) (aka fc receptor, igg, high affi... | [T; R; H; K] |
<Instruct>: Given the context 'Remarkably, the recently identified mouse IFN-producing cells (mIPCs) were absent in all lymphoid organs from ICSBP(-/-) mice, as revealed by lack of CD11c(low)B220(+)Ly6C(+)CD11b(-) cells.', select the correct biomedical concept for each mention using the provided options. In the answer,... | <Mentions>: [ifn; icsbp; cd11c; b220]
<Options>: A: cd79a (homo sapiens) (aka cd79a molecule)
B: ifna (homo sapiens) (interferon, type 1, cluster (homo sapiens)) (aka interferon, type 1, cluster)
C: ifn-alpha (homo sapiens) (aka interferon alpha 1)
D: cd20 (mus musculus) (aka membrane-spanning 4-domains, subfamily a, m... | [M; G; R; F] |
<Instruct>: Given the context 'Remarkably, the recently identified mouse IFN-producing cells (mIPCs) were absent in all lymphoid organs from ICSBP(-/-) mice, as revealed by lack of CD11c(low)B220(+)Ly6C(+)CD11b(-) cells.', select the correct biomedical concept for each mention using the provided options. In the answer,... | <Mentions>: [ifn; icsbp; cd11c; b220]
<Options>: A: icsbp1 (rattus norvegicus) (aka interferon regulatory factor 8)
B: cd45r (homo sapiens) (aka protein tyrosine phosphatase receptor type c)
C: icsbp (mus musculus) (aka interferon regulatory factor 8)
D: cd1 (homo sapiens) (cd1a molecule (homo sapiens)) (aka cd1a molec... | [P; C; I; O] |
<Instruct>: Given the context 'Remarkably, the recently identified mouse IFN-producing cells (mIPCs) were absent in all lymphoid organs from ICSBP(-/-) mice, as revealed by lack of CD11c(low)B220(+)Ly6C(+)CD11b(-) cells.', select the correct biomedical concept for each mention using the provided options. In the answer,... | <Mentions>: [ifn; icsbp; cd11c; b220]
<Options>: A: illbp (mus musculus) (aka fatty acid binding protein 6)
B: cd79a (homo sapiens) (aka cd79a molecule)
C: cd45r (mus musculus) (aka protein tyrosine phosphatase receptor type c)
D: ifnaa (mus musculus) (aka interferon alpha 15)
E: cd11c (mus musculus) (aka integrin alph... | [P; O; E; C] |
<Instruct>: Given the context 'Remarkably, the recently identified mouse IFN-producing cells (mIPCs) were absent in all lymphoid organs from ICSBP(-/-) mice, as revealed by lack of CD11c(low)B220(+)Ly6C(+)CD11b(-) cells.', select the correct biomedical concept for each mention using the provided options. In the answer,... | <Mentions>: [ly6c; cd11b]
<Options>: A: cd11b (danio rerio) (aka integrin, alpha m (complement component 3 receptor 3 subunit), tandem duplicate 1)
B: mac-1 (homo sapiens) (integrin subunit beta 2 (homo sapiens)) (aka integrin subunit beta 2)
C: ly-c (mus musculus) (aka cd8 subunit beta 1)
D: cd11b (homo sapiens) (aka ... | [H; I] |
<Instruct>: Given the context 'Remarkably, the recently identified mouse IFN-producing cells (mIPCs) were absent in all lymphoid organs from ICSBP(-/-) mice, as revealed by lack of CD11c(low)B220(+)Ly6C(+)CD11b(-) cells.', select the correct biomedical concept for each mention using the provided options. In the answer,... | <Mentions>: [ly6c; cd11b]
<Options>: A: ly6-c antigen (rattus norvegicus) (aka ly6-c antigen)
B: cd11b (rattus norvegicus) (aka integrin subunit alpha m)
C: ly6 (mus musculus) (aka lymphocyte antigen 6 complex)
D: cd61 (homo sapiens) (aka integrin subunit beta 3)
E: ly-c (mus musculus) (aka cd8 subunit beta 1)
F: cd11b... | [H; J] |
<Instruct>: Given the context 'In parallel, CD11c(+) cells isolated from ICSBP(-/-) spleens were unable to produce type I IFNs in response to viral stimulation.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated b... | <Mentions>: [cd11c; icsbp; type i ifns]
<Options>: A: ifnb1 (homo sapiens) (aka interferon beta 1)
B: cd11c (homo sapiens) (aka integrin subunit alpha x)
C: interferon, type 1, cluster (homo sapiens) (aka interferon, type 1, cluster)
D: cd103 (mus musculus) (aka integrin alpha e, epithelial-associated)
E: cd103 (homo s... | [N; K; G] |
<Instruct>: Given the context 'In parallel, CD11c(+) cells isolated from ICSBP(-/-) spleens were unable to produce type I IFNs in response to viral stimulation.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated b... | <Mentions>: [cd11c; icsbp; type i ifns]
<Options>: A: cd11b (homo sapiens) (aka integrin subunit alpha m)
B: cd11c (mus musculus) (aka integrin alpha x)
C: cd1 (homo sapiens) (cd1a molecule (homo sapiens)) (aka cd1a molecule)
D: ifn1@ (homo sapiens) (aka interferon, type 1, cluster)
E: ifng (homo sapiens) (aka interfer... | [B; J; M] |
<Instruct>: Given the context 'In parallel, CD11c(+) cells isolated from ICSBP(-/-) spleens were unable to produce type I IFNs in response to viral stimulation.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated b... | <Mentions>: [cd11c; icsbp; type i ifns]
<Options>: A: cd11c (homo sapiens) (aka integrin subunit alpha x)
B: cd14 (mus musculus) (aka cd14 antigen)
C: ifn (homo sapiens) (aka interferon alpha 1)
D: stat1 (mus musculus) (aka signal transducer and activator of transcription 1)
E: ilbp (mus musculus) (aka fatty acid bindi... | [G; M; H] |
<Instruct>: Given the context 'ICSBP(-/-) mice also displayed a marked reduction of the DC subset expressing the CD8alpha marker (CD8alpha(+) DCs) in spleen, lymph nodes, and thymus.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for eac... | <Mentions>: [icsbp; cd8alpha]
<Options>: A: icsbp (mus musculus) (aka interferon regulatory factor 8)
B: ilbp (homo sapiens) (aka fatty acid binding protein 6)
C: cd8 (homo sapiens) (aka cd8 subunit alpha)
D: cd8a (mus musculus) (aka cd8 subunit alpha)
E: cd8b1 (mus musculus) (aka cd8 subunit beta 1)
F: ilbp (mus muscu... | [A; D] |
<Instruct>: Given the context 'ICSBP(-/-) mice also displayed a marked reduction of the DC subset expressing the CD8alpha marker (CD8alpha(+) DCs) in spleen, lymph nodes, and thymus.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for eac... | <Mentions>: [icsbp; cd8alpha]
<Options>: A: icsbp1 (rattus norvegicus) (aka interferon regulatory factor 8)
B: cd8 subunit beta (homo sapiens) (aka cd8 subunit beta)
C: cd8b1 (mus musculus) (aka cd8 subunit beta 1)
D: ilbp (homo sapiens) (aka fatty acid binding protein 6)
E: ilbp (mus musculus) (aka fatty acid binding ... | [F; J] |
<Instruct>: Given the context 'ICSBP(-/-) mice also displayed a marked reduction of the DC subset expressing the CD8alpha marker (CD8alpha(+) DCs) in spleen, lymph nodes, and thymus.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for eac... | <Mentions>: [icsbp; cd8alpha]
<Options>: A: cd8 subunit alpha (mus musculus) (aka cd8 subunit alpha)
B: cd8b1 (mus musculus) (aka cd8 subunit beta 1)
C: ilbp (mus musculus) (aka fatty acid binding protein 6)
D: icsbp (rattus norvegicus) (aka interferon regulatory factor 8)
E: icsbp (homo sapiens) (aka interferon regula... | [J; A] |
<Instruct>: Given the context 'Moreover, ICSBP(-/-) CD8alpha(+) DCs exhibited a markedly impaired phenotype when compared with WT DCs.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [icsbp; cd8alpha]
<Options>: A: illbp (mus musculus) (aka fatty acid binding protein 6)
B: cd8 subunit alpha (mus musculus) (aka cd8 subunit alpha)
C: icsbp1 (homo sapiens) (aka interferon regulatory factor 8)
D: cd8 subunit beta (homo sapiens) (aka cd8 subunit beta)
E: cd8a (homo sapiens) (aka cd8 subunit ... | [J; B] |
<Instruct>: Given the context 'Moreover, ICSBP(-/-) CD8alpha(+) DCs exhibited a markedly impaired phenotype when compared with WT DCs.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [icsbp; cd8alpha]
<Options>: A: icsbp1 (homo sapiens) (aka interferon regulatory factor 8)
B: cd8alpha (homo sapiens) (aka cd8 subunit alpha)
C: cd8 subunit beta (homo sapiens) (aka cd8 subunit beta)
D: icsbp1 (rattus norvegicus) (aka interferon regulatory factor 8)
E: ilbp (homo sapiens) (aka fatty acid bi... | [I; J] |
<Instruct>: Given the context 'They expressed very low levels of costimulatory molecules (intercellular adhesion molecule [ICAM]-1, CD40, CD80, CD86) and of the T cell area-homing chemokine receptor CCR7, whereas they showed higher levels of CCR2 and CCR6, as revealed by reverse transcription PCR.', select the correct ... | <Mentions>: [intercellular adhesion molecule [icam]-1; cd40; cd80; cd86]
<Options>: A: p50 (homo sapiens) (cd40 molecule (homo sapiens)) (aka cd40 molecule)
B: cd40l (homo sapiens) (aka cd40 ligand)
C: cd80 molecule (homo sapiens) (aka cd80 molecule)
D: cd86 molecule (rattus norvegicus) (aka cd86 molecule)
E: cd86 (mus... | [R; O; P; E] |
<Instruct>: Given the context 'They expressed very low levels of costimulatory molecules (intercellular adhesion molecule [ICAM]-1, CD40, CD80, CD86) and of the T cell area-homing chemokine receptor CCR7, whereas they showed higher levels of CCR2 and CCR6, as revealed by reverse transcription PCR.', select the correct ... | <Mentions>: [intercellular adhesion molecule [icam]-1; cd40; cd80; cd86]
<Options>: A: cd86 (mus musculus) (aka cd86 antigen)
B: cd80 molecule (rattus norvegicus) (aka cd80 molecule)
C: cd40l (mus musculus) (aka cd40 ligand)
D: cd80 molecule (homo sapiens) (aka cd80 molecule)
E: p50 (homo sapiens) (cd40 molecule (homo ... | [R; O; I; A] |
<Instruct>: Given the context 'They expressed very low levels of costimulatory molecules (intercellular adhesion molecule [ICAM]-1, CD40, CD80, CD86) and of the T cell area-homing chemokine receptor CCR7, whereas they showed higher levels of CCR2 and CCR6, as revealed by reverse transcription PCR.', select the correct ... | <Mentions>: [intercellular adhesion molecule [icam]-1; cd40; cd80; cd86]
<Options>: A: intercellular adhesion molecule 1 (rattus norvegicus) (aka intercellular adhesion molecule 1)
B: cd40l (homo sapiens) (aka cd40 ligand)
C: p50 (homo sapiens) (cd40 molecule (homo sapiens)) (aka cd40 molecule)
D: cd86 molecule (homo s... | [E; R; H; K] |
<Instruct>: Given the context 'They expressed very low levels of costimulatory molecules (intercellular adhesion molecule [ICAM]-1, CD40, CD80, CD86) and of the T cell area-homing chemokine receptor CCR7, whereas they showed higher levels of CCR2 and CCR6, as revealed by reverse transcription PCR.', select the correct ... | <Mentions>: [intercellular adhesion molecule [icam]-1; cd40; cd80; cd86]
<Options>: A: cd80 (rattus norvegicus) (aka cd80 molecule)
B: cd80 molecule (homo sapiens) (aka cd80 molecule)
C: cd40 (mus musculus) (aka cd40 antigen)
D: cd86 (homo sapiens) (aka cd86 molecule)
E: cd86 molecule (rattus norvegicus) (aka cd86 mole... | [M; C; K; N] |
<Instruct>: Given the context 'They expressed very low levels of costimulatory molecules (intercellular adhesion molecule [ICAM]-1, CD40, CD80, CD86) and of the T cell area-homing chemokine receptor CCR7, whereas they showed higher levels of CCR2 and CCR6, as revealed by reverse transcription PCR.', select the correct ... | <Mentions>: [intercellular adhesion molecule [icam]-1; cd40; cd80; cd86]
<Options>: A: icam (rattus norvegicus) (aka intercellular adhesion molecule 1)
B: cd40 (homo sapiens) (aka cd40 molecule)
C: cd86 antigen (mus musculus) (aka cd86 antigen)
D: cd40l (mus musculus) (aka cd40 ligand)
E: intercellular adhesion molecul... | [Q; H; M; C] |
<Instruct>: Given the context 'They expressed very low levels of costimulatory molecules (intercellular adhesion molecule [ICAM]-1, CD40, CD80, CD86) and of the T cell area-homing chemokine receptor CCR7, whereas they showed higher levels of CCR2 and CCR6, as revealed by reverse transcription PCR.', select the correct ... | <Mentions>: [ccr7; ccr2; ccr6]
<Options>: A: ccr2 (danio rerio) (aka chemokine (c-c motif) receptor 2)
B: c-x-c motif chemokine receptor 6 (mus musculus) (aka c-x-c motif chemokine receptor 6)
C: ccr6 (rattus norvegicus) (aka c-c motif chemokine receptor 6)
D: c-c motif chemokine receptor 7 (homo sapiens) (aka c-c moti... | [G; J; F] |
<Instruct>: Given the context 'They expressed very low levels of costimulatory molecules (intercellular adhesion molecule [ICAM]-1, CD40, CD80, CD86) and of the T cell area-homing chemokine receptor CCR7, whereas they showed higher levels of CCR2 and CCR6, as revealed by reverse transcription PCR.', select the correct ... | <Mentions>: [ccr7; ccr2; ccr6]
<Options>: A: c-x-c motif chemokine receptor 6 (mus musculus) (aka c-x-c motif chemokine receptor 6)
B: ccr2 (rattus norvegicus) (aka c-c motif chemokine receptor 2)
C: ccr6 (rattus norvegicus) (aka c-c motif chemokine receptor 6)
D: ccr2 (mus musculus) (aka c-c motif chemokine receptor 2... | [E; I; F] |
<Instruct>: Given the context 'They expressed very low levels of costimulatory molecules (intercellular adhesion molecule [ICAM]-1, CD40, CD80, CD86) and of the T cell area-homing chemokine receptor CCR7, whereas they showed higher levels of CCR2 and CCR6, as revealed by reverse transcription PCR.', select the correct ... | <Mentions>: [ccr7; ccr2; ccr6]
<Options>: A: ccr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: c-c motif chemokine receptor 2 (homo sapiens) (aka c-c motif chemokine receptor 2)
C: c-x-c motif chemokine receptor 6 (mus musculus) (aka c-x-c motif chemokine receptor 6)
D: ccr7 (danio rerio) (aka chemokine (c-c ... | [J; I; K] |
<Instruct>: Given the context 'In addition, these cells were unable to undergo full phenotypic activation upon in vitro culture in presence of maturation stimuli such as lipopolysaccharide or poly (I:C), which paralleled with lack of Toll-like receptor (TLR)3 mRNA expression.', select the correct biomedical concept for... | <Mentions>: [toll-like receptor (tlr)3]
<Options>: A: toll-like receptor 3 (dermatophagoides pteronyssinus) (aka toll-like receptor 3)
B: tlr3 (homo sapiens) (aka toll like receptor 3)
C: toll3 (drosophila melanogaster) (aka mstprox)
D: toll-like receptor 3 (mus musculus) (aka toll-like receptor 3)
E: tlr3 (rattus norv... | [D] |
<Instruct>: Given the context 'Finally, cytokine expression pattern was also altered in ICSBP(-/-)', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [icsbp]
<Options>: A: illbp (mus musculus) (aka fatty acid binding protein 6)
B: icsbp1 (rattus norvegicus) (aka interferon regulatory factor 8)
C: h-icsbp (homo sapiens) (aka interferon regulatory factor 8)
D: ilbp (homo sapiens) (aka fatty acid binding protein 6)
E: icsbp (mus musculus) (aka interferon re... | [E] |
<Instruct>: Given the context 'DCs, as they did not express interleukin (IL)-12p40 or IL-15, but they displayed detectable IL-4 mRNA levels.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [interleukin (il)-12p40; il-15; il-4]
<Options>: A: il15 (homo sapiens) (aka interleukin 15)
B: interleukin 12b (homo sapiens) (aka interleukin 12b)
C: interleukin 12a (mus musculus) (aka interleukin 12a)
D: il5 (homo sapiens) (aka interleukin 5)
E: il-12a (homo sapiens) (aka interleukin 12a)
F: il15 (mus m... | [K; F; H] |
<Instruct>: Given the context 'DCs, as they did not express interleukin (IL)-12p40 or IL-15, but they displayed detectable IL-4 mRNA levels.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [interleukin (il)-12p40; il-15; il-4]
<Options>: A: interleukin 12a (mus musculus) (aka interleukin 12a)
B: il4 (ovis aries) (aka interleukin 4)
C: interleukin 4 (rattus norvegicus) (aka interleukin 4)
D: interleukin 15 (rattus norvegicus) (aka interleukin 15)
E: il4 (homo sapiens) (aka interleukin 4)
F: il... | [J; L; M] |
<Instruct>: Given the context 'DCs, as they did not express interleukin (IL)-12p40 or IL-15, but they displayed detectable IL-4 mRNA levels.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [interleukin (il)-12p40; il-15; il-4]
<Options>: A: il5 (homo sapiens) (aka interleukin 5)
B: interleukin 4 (rattus norvegicus) (aka interleukin 4)
C: il-15 (mus musculus) (aka interleukin 15)
D: interleukin 12a (mus musculus) (aka interleukin 12a)
E: interleukin 4 (homo sapiens) (aka interleukin 4)
F: il-1... | [F; C; I] |
<Instruct>: Given the context 'On the whole, these results indicate that ICSBP is a crucial factor in the regulation of two possibly linked processes: (a) the development and activity of mIPCs, whose lack in ICSBP(-/-) mice may explain their high susceptibility to virus infections; (b) the generation and activation of ... | <Mentions>: [icsbp; cd8alpha]
<Options>: A: h-icsbp (homo sapiens) (aka interferon regulatory factor 8)
B: cd8 subunit alpha (mus musculus) (aka cd8 subunit alpha)
C: icsbp1 (rattus norvegicus) (aka interferon regulatory factor 8)
D: cd8 (homo sapiens) (aka cd8 subunit alpha)
E: ilbp (homo sapiens) (aka fatty acid bind... | [J; B] |
<Instruct>: Given the context 'On the whole, these results indicate that ICSBP is a crucial factor in the regulation of two possibly linked processes: (a) the development and activity of mIPCs, whose lack in ICSBP(-/-) mice may explain their high susceptibility to virus infections; (b) the generation and activation of ... | <Mentions>: [icsbp; cd8alpha]
<Options>: A: illbp (mus musculus) (aka fatty acid binding protein 6)
B: ilbp (homo sapiens) (aka fatty acid binding protein 6)
C: cd8a (mus musculus) (aka cd8 subunit alpha)
D: icsbp (mus musculus) (aka interferon regulatory factor 8)
E: cd8 subunit beta (homo sapiens) (aka cd8 subunit be... | [D; C] |
<Instruct>: Given the context 'Sarco(endo)plasmic reticulum Ca2+-ATPase-2 gene: structure and transcriptional regulation of the human gene.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [sarco(endo)plasmic reticulum ca2+-atpase-2]
<Options>: A: atpase sarcoplasmic/endoplasmic reticulum ca2+ transporting 2 (homo sapiens) (aka atpase sarcoplasmic/endoplasmic reticulum ca2+ transporting 2)
B: atpase plasma membrane ca2+ transporting 2 (homo sapiens) (aka atpase plasma membrane ca2+ transporti... | [A] |
<Instruct>: Given the context 'The sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs) belong to a family of active calcium transport enzymes encoded by the SERCA1, 2, and 3 genes.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each m... | <Mentions>: [serca1, 2, and 3]
<Options>: A: serca2 (mus musculus) (aka atpase, ca++ transporting, cardiac muscle, slow twitch 2)
B: atpase sarcoplasmic/endoplasmic reticulum ca2+ transporting 1 (homo sapiens) (aka atpase sarcoplasmic/endoplasmic reticulum ca2+ transporting 1)
C: serca3 (homo sapiens) (aka atpase sarco... | [B] |
<Instruct>: Given the context 'In this study, we describe the complete structure of the human SERCA2 gene and its 5 -regulatory region.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [serca2]
<Options>: A: atpase sarcoplasmic/endoplasmic reticulum ca2+ transporting 2 (homo sapiens) (aka atpase sarcoplasmic/endoplasmic reticulum ca2+ transporting 2)
B: atp2a (homo sapiens) (aka atpase sarcoplasmic/endoplasmic reticulum ca2+ transporting 1)
C: serca2a (mus musculus) (aka atpase, ca++ tran... | [A] |
<Instruct>: Given the context 'The hSERCA2 gene is located in chromosome 12 position q24.1 in Contig NT_009770.8, spans 70 kb, and is organized in 21 exons intervened by 20 introns.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each... | <Mentions>: [hserca2]
<Options>: A: ces2a (rattus norvegicus) (aka carboxylesterase 2a)
B: smarca2 (rattus norvegicus) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
C: smarca2 (mus musculus) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
D: ces2a (mus musculus) (aka ca... | [F] |
<Instruct>: Given the context 'The last two exons of the pre-mRNA produce by alternatively splicing the cardiac/slow-twitch muscle-specific SERCA2a isoform and the ubiquitous SERCA2b isoform.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, on... | <Mentions>: [serca2a; serca2b]
<Options>: A: serca2 (rattus norvegicus) (aka atpase sarcoplasmic/endoplasmic reticulum ca2+ transporting 2)
B: serca3b (mus musculus) (aka atpase, ca++ transporting, ubiquitous)
C: serca2a (mus musculus) (aka atpase, ca++ transporting, cardiac muscle, slow twitch 2)
D: atp2a (homo sapien... | [G; F] |
<Instruct>: Given the context 'The last two exons of the pre-mRNA produce by alternatively splicing the cardiac/slow-twitch muscle-specific SERCA2a isoform and the ubiquitous SERCA2b isoform.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, on... | <Mentions>: [serca2a; serca2b]
<Options>: A: atp2a (homo sapiens) (aka atpase sarcoplasmic/endoplasmic reticulum ca2+ transporting 1)
B: atp2b (homo sapiens) (aka atpase sarcoplasmic/endoplasmic reticulum ca2+ transporting 2)
C: serca2 (rattus norvegicus) (aka atpase sarcoplasmic/endoplasmic reticulum ca2+ transporting... | [D; B] |
<Instruct>: Given the context 'The sequence of the proximal 225-bp regulatory region of the SERCA2 genes is 80% G+C-rich and is conserved among human, rabbit, rat, and mouse species.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for eac... | <Mentions>: [serca2]
<Options>: A: atp2a (homo sapiens) (aka atpase sarcoplasmic/endoplasmic reticulum ca2+ transporting 1)
B: serca2 (mus musculus) (aka atpase, ca++ transporting, cardiac muscle, slow twitch 2)
C: atpase sarcoplasmic/endoplasmic reticulum ca2+ transporting 2 (homo sapiens) (aka atpase sarcoplasmic/end... | [C] |
<Instruct>: Given the context 'It contains a TATA-like-box, an E-box/USF sequence, a CAAT-box, four Sp1 binding sites, and a thyroid hormone responsive element (TRE).', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separ... | <Mentions>: [sp1]
<Options>: A: h-sp1 (homo sapiens) (aka synaptophysin like 1)
B: sp1 (rattus norvegicus) (aka sp1 transcription factor)
C: sp1 (cricetulus griseus) (aka sp1 transcription factor)
D: sp1 (homo sapiens) (sp1 transcription factor (homo sapiens)) (aka sp1 transcription factor)
E: sp1 (xenopus laevis) (aka... | [D] |
<Instruct>: Given the context 'Among the DNA cis-elements present in these two regulatory regions there are potential binding sites for: GATA-4, -5, -6, Nkx-2.5/Csx, OTF-1, USF, MEF-2, SRF, PPAR/RXR, AP-2, and TREs.', select the correct biomedical concept for each mention using the provided options. In the answer, list... | <Mentions>: [gata-4, -5, -6; nkx-2.5; csx; otf-1]
<Options>: A: otf1 (homo sapiens) (aka pou class 2 homeobox 1)
B: csx (xenopus laevis) (nk2 homeobox 5 l homeolog (xenopus laevis)) (aka nk2 homeobox 5 l homeolog)
C: csx3 (homo sapiens) (aka nk2 homeobox 3)
D: scx (homo sapiens) (aka scleraxis bhlh transcription factor... | [T; Q; J; A] |
<Instruct>: Given the context 'Among the DNA cis-elements present in these two regulatory regions there are potential binding sites for: GATA-4, -5, -6, Nkx-2.5/Csx, OTF-1, USF, MEF-2, SRF, PPAR/RXR, AP-2, and TREs.', select the correct biomedical concept for each mention using the provided options. In the answer, list... | <Mentions>: [gata-4, -5, -6; nkx-2.5; csx; otf-1]
<Options>: A: oligodendrocyte transcription factor 1 (mus musculus) (aka oligodendrocyte transcription factor 1)
B: csx (mus musculus) (aka nk2 homeobox 5)
C: gata binding protein 6 (mus musculus) (aka gata binding protein 6)
D: scx (homo sapiens) (aka scleraxis bhlh tr... | [O; H; B; T] |
<Instruct>: Given the context 'Among the DNA cis-elements present in these two regulatory regions there are potential binding sites for: GATA-4, -5, -6, Nkx-2.5/Csx, OTF-1, USF, MEF-2, SRF, PPAR/RXR, AP-2, and TREs.', select the correct biomedical concept for each mention using the provided options. In the answer, list... | <Mentions>: [gata-4, -5, -6; nkx-2.5; csx; otf-1]
<Options>: A: csx (homo sapiens) (aka nk2 homeobox 5)
B: gata5 (mus musculus) (aka gata binding protein 5)
C: csx3 (homo sapiens) (aka nk2 homeobox 3)
D: nkx-2.5 (mus musculus) (aka nk2 homeobox 5)
E: nkx-2.6 (mus musculus) (aka nk2 homeobox 6)
F: gata6 (homo sapiens) (... | [K; D; G; R] |
<Instruct>: Given the context 'Among the DNA cis-elements present in these two regulatory regions there are potential binding sites for: GATA-4, -5, -6, Nkx-2.5/Csx, OTF-1, USF, MEF-2, SRF, PPAR/RXR, AP-2, and TREs.', select the correct biomedical concept for each mention using the provided options. In the answer, list... | <Mentions>: [gata-4, -5, -6; nkx-2.5; csx; otf-1]
<Options>: A: pou domain, class 1, transcription factor 1 (mus musculus) (aka pou domain, class 1, transcription factor 1)
B: csx (xenopus laevis) (nk2 homeobox 5 l homeolog (xenopus laevis)) (aka nk2 homeobox 5 l homeolog)
C: otf1 (homo sapiens) (aka pou class 2 homeob... | [J; N; I; C] |
<Instruct>: Given the context 'Among the DNA cis-elements present in these two regulatory regions there are potential binding sites for: GATA-4, -5, -6, Nkx-2.5/Csx, OTF-1, USF, MEF-2, SRF, PPAR/RXR, AP-2, and TREs.', select the correct biomedical concept for each mention using the provided options. In the answer, list... | <Mentions>: [gata-4, -5, -6; nkx-2.5; csx; otf-1]
<Options>: A: csx (xenopus laevis) (nk2 homeobox 5 l homeolog (xenopus laevis)) (aka nk2 homeobox 5 l homeolog)
B: otf1 (homo sapiens) (aka pou class 2 homeobox 1)
C: gata6 (rattus norvegicus) (aka gata binding protein 6)
D: nkx-5.1 (mus musculus) (aka h6 homeobox 3)
E:... | [C; I; N; B] |
<Instruct>: Given the context 'Among the DNA cis-elements present in these two regulatory regions there are potential binding sites for: GATA-4, -5, -6, Nkx-2.5/Csx, OTF-1, USF, MEF-2, SRF, PPAR/RXR, AP-2, and TREs.', select the correct biomedical concept for each mention using the provided options. In the answer, list... | <Mentions>: [srf; ap-2]
<Options>: A: transcription factor ap-2 (drosophila melanogaster) (aka transcription factor ap-2)
B: srf (xenopus laevis) (aka serum response factor l homeolog)
C: transcription factor ap-2 alpha (rattus norvegicus) (aka transcription factor ap-2 alpha)
D: srf (danio rerio) (aka serum response f... | [I; J] |
<Instruct>: Given the context 'Among the DNA cis-elements present in these two regulatory regions there are potential binding sites for: GATA-4, -5, -6, Nkx-2.5/Csx, OTF-1, USF, MEF-2, SRF, PPAR/RXR, AP-2, and TREs.', select the correct biomedical concept for each mention using the provided options. In the answer, list... | <Mentions>: [srf; ap-2]
<Options>: A: transcription factor ap-2 alpha (rattus norvegicus) (aka transcription factor ap-2 alpha)
B: serum response factor (homo sapiens) (aka serum response factor)
C: transcription factor ap-2 alpha (homo sapiens) (aka transcription factor ap-2 alpha)
D: ap-2(beta) (mus musculus) (aka tr... | [B; C] |
<Instruct>: Given the context 'Upstream from position -1.5 kb, there is no significant homology among the SERCA2 genes cloned.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [serca2]
<Options>: A: sercaii (rattus norvegicus) (aka atpase sarcoplasmic/endoplasmic reticulum ca2+ transporting 2)
B: serca2 (danio rerio) (aka atpase sarcoplasmic/endoplasmic reticulum ca2+ transporting 2b)
C: serca2b (mus musculus) (aka atpase, ca++ transporting, cardiac muscle, slow twitch 2)
D: atpa... | [D] |
<Instruct>: Given the context 'In this study, we report the cloning of 2.4 kb of 5-regulatory region and demonstrate that the proximal promoter region is sufficient for expression in cardiac myocytes, and the region from -225 to -1232 bp contains regulatory DNA elements which down-regulate the expression of the SERCA2 ... | <Mentions>: [serca2]
<Options>: A: serca2 (rattus norvegicus) (aka atpase sarcoplasmic/endoplasmic reticulum ca2+ transporting 2)
B: serca2 (danio rerio) (aka atpase sarcoplasmic/endoplasmic reticulum ca2+ transporting 2b)
C: serca2b (mus musculus) (aka atpase, ca++ transporting, cardiac muscle, slow twitch 2)
D: serca... | [D] |
<Instruct>: Given the context 'Atherosclerosis is an inflammatory disease in which a perpetuated activation of NFkappaB via the RAGE (receptor for advanced glycation end products)-MAPK signalling pathway may play an important pathogenetic role.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [nfkappab; rage; receptor for advanced glycation end products]
<Options>: A: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
B: rage (homo sapiens) (advanced glycosylation end-product specific receptor (homo sapiens)) (aka advanced glycosylation end-product specifi... | [L; B; F] |
<Instruct>: Given the context 'Atherosclerosis is an inflammatory disease in which a perpetuated activation of NFkappaB via the RAGE (receptor for advanced glycation end products)-MAPK signalling pathway may play an important pathogenetic role.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [nfkappab; rage; receptor for advanced glycation end products]
<Options>: A: rage (mus musculus) (mok protein kinase (mus musculus)) (aka mok protein kinase)
B: rage (homo sapiens) (advanced glycosylation end-product specific receptor (homo sapiens)) (aka advanced glycosylation end-product specific receptor... | [L; B; K] |
<Instruct>: Given the context 'Atherosclerosis is an inflammatory disease in which a perpetuated activation of NFkappaB via the RAGE (receptor for advanced glycation end products)-MAPK signalling pathway may play an important pathogenetic role.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [nfkappab; rage; receptor for advanced glycation end products]
<Options>: A: nf-kappab (homo sapiens) (aka nuclear factor kappa b subunit 1)
B: rage1 (mus musculus) (aka mok protein kinase)
C: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
D: rage (rattus norvegic... | [A; H; J] |
<Instruct>: Given the context 'As recently S100 proteins have been identified as ligands of RAGE, we sought to determine the effects of the proinflammatory heterodimer of S100A8/S100A9 on the RAGE-NFkappaB mediated induction of proinflammatory gene expression.', select the correct biomedical concept for each mention us... | <Mentions>: [rage; s100a8; s100a9]
<Options>: A: s100a9 (homo sapiens) (aka s100 calcium binding protein a9)
B: s100 calcium binding protein a8 (homo sapiens) (aka s100 calcium binding protein a8)
C: gfr (homo sapiens) (aka rap guanine nucleotide exchange factor 5)
D: s100a9 (mus musculus) (aka s100 calcium binding pro... | [I; B; A] |
<Instruct>: Given the context 'As recently S100 proteins have been identified as ligands of RAGE, we sought to determine the effects of the proinflammatory heterodimer of S100A8/S100A9 on the RAGE-NFkappaB mediated induction of proinflammatory gene expression.', select the correct biomedical concept for each mention us... | <Mentions>: [rage; s100a8; s100a9]
<Options>: A: s100a9 (mus musculus) (aka s100 calcium binding protein a9 (calgranulin b))
B: gfr (homo sapiens) (aka rap guanine nucleotide exchange factor 5)
C: rage1 (mus musculus) (aka mok protein kinase)
D: rage (homo sapiens) (advanced glycosylation end-product specific receptor ... | [D; K; E] |
<Instruct>: Given the context 'As recently S100 proteins have been identified as ligands of RAGE, we sought to determine the effects of the proinflammatory heterodimer of S100A8/S100A9 on the RAGE-NFkappaB mediated induction of proinflammatory gene expression.', select the correct biomedical concept for each mention us... | <Mentions>: [rage; s100a8; s100a9]
<Options>: A: s100 calcium binding protein a8 (rattus norvegicus) (aka s100 calcium binding protein a8)
B: s100 calcium binding protein a8 (calgranulin a) (mus musculus) (aka s100 calcium binding protein a8 (calgranulin a))
C: rage (rattus norvegicus) (mok protein kinase (rattus norve... | [F; D; E] |
<Instruct>: Given the context 'As recently S100 proteins have been identified as ligands of RAGE, we sought to determine the effects of the proinflammatory heterodimer of S100A8/S100A9 on the RAGE-NFkappaB mediated induction of proinflammatory gene expression.', select the correct biomedical concept for each mention us... | <Mentions>: [rage; s100a8; s100a9]
<Options>: A: rage (homo sapiens) (mok protein kinase (homo sapiens)) (aka mok protein kinase)
B: s100a9 (rattus norvegicus) (aka s100 calcium binding protein a9)
C: s100a8 (mus musculus) (aka s100 calcium binding protein a8 (calgranulin a))
D: gfr (homo sapiens) (aka rap guanine nucl... | [I; J; F] |
<Instruct>: Given the context 'As recently S100 proteins have been identified as ligands of RAGE, we sought to determine the effects of the proinflammatory heterodimer of S100A8/S100A9 on the RAGE-NFkappaB mediated induction of proinflammatory gene expression.', select the correct biomedical concept for each mention us... | <Mentions>: [nfkappab]
<Options>: A: nf-kappab (mus musculus) (aka nuclear factor of kappa light polypeptide gene enhancer in b cells 1, p105)
B: nfkb (rattus norvegicus) (aka rela proto-oncogene, nf-kb subunit)
C: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
D: nfkappab (h... | [D] |
<Instruct>: Given the context 'Human umbilical vein endothelial cells (HUVEC) were preincubated for 72 h with AGE-albumin or unmodified albumin for control, whereas AGE-albumin induction resulted in an upregulation of RAGE.', select the correct biomedical concept for each mention using the provided options. In the answ... | <Mentions>: [rage]
<Options>: A: rage (rattus norvegicus) (advanced glycosylation end product-specific receptor (rattus norvegicus)) (aka advanced glycosylation end product-specific receptor)
B: gfr (homo sapiens) (aka rap guanine nucleotide exchange factor 5)
C: rage (homo sapiens) (advanced glycosylation end-product ... | [C] |
<Instruct>: Given the context 'Following this preactivation, cells were stimulated for 48 h with heterodimeric human recombinant S100A8/S100A9.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [s100a8; s100a9]
<Options>: A: s100a8 (rattus norvegicus) (aka s100 calcium binding protein a8)
B: s100 calcium binding protein a9 (rattus norvegicus) (aka s100 calcium binding protein a9)
C: s100-a8 (homo sapiens) (aka s100 calcium binding protein a8)
D: p8 (mus musculus) (s100 calcium binding protein a8 (... | [C; E] |
<Instruct>: Given the context 'Following this preactivation, cells were stimulated for 48 h with heterodimeric human recombinant S100A8/S100A9.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [s100a8; s100a9]
<Options>: A: s100 calcium binding protein a9 (rattus norvegicus) (aka s100 calcium binding protein a9)
B: p14 (mus musculus) (s100 calcium binding protein a9 (calgranulin b) (mus musculus)) (aka s100 calcium binding protein a9 (calgranulin b))
C: s100-a8 (homo sapiens) (aka s100 calcium bi... | [C; F] |
<Instruct>: Given the context 'Following this preactivation, cells were stimulated for 48 h with heterodimeric human recombinant S100A8/S100A9.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [s100a8; s100a9]
<Options>: A: s100a9 (rattus norvegicus) (aka s100 calcium binding protein a9)
B: p8 (mus musculus) (s100 calcium binding protein a8 (calgranulin a) (mus musculus)) (aka s100 calcium binding protein a8 (calgranulin a))
C: p14 (homo sapiens) (s100 calcium binding protein a9 (homo sapiens)) (... | [F; C] |
<Instruct>: Given the context 'Heterodimeric S100A8/S100A9 enhanced secretion of IL-6, ICAM-1, VCAM-1 and MCP1 in AGE-albumin pretreated HUVEC in a dose dependent manner.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, s... | <Mentions>: [s100a8; s100a9; il-6; icam-1]
<Options>: A: cd51 (mus musculus) (aka integrin alpha v)
B: s100a8 (homo sapiens) (aka s100 calcium binding protein a8)
C: s100 calcium binding protein a8 (calgranulin a) (mus musculus) (aka s100 calcium binding protein a8 (calgranulin a))
D: s100 calcium binding protein a9 (h... | [B; D; H; P] |
<Instruct>: Given the context 'Heterodimeric S100A8/S100A9 enhanced secretion of IL-6, ICAM-1, VCAM-1 and MCP1 in AGE-albumin pretreated HUVEC in a dose dependent manner.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, s... | <Mentions>: [s100a8; s100a9; il-6; icam-1]
<Options>: A: nf-il6 (mus musculus) (aka ccaat/enhancer binding protein beta)
B: vcam-1 (mus musculus) (aka vascular cell adhesion molecule 1)
C: icam1 (homo sapiens) (aka intercellular adhesion molecule 1)
D: icam1 (rattus norvegicus) (aka intercellular adhesion molecule 1)
E... | [N; O; K; C] |
<Instruct>: Given the context 'Heterodimeric S100A8/S100A9 enhanced secretion of IL-6, ICAM-1, VCAM-1 and MCP1 in AGE-albumin pretreated HUVEC in a dose dependent manner.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, s... | <Mentions>: [s100a8; s100a9; il-6; icam-1]
<Options>: A: icam1 (mus musculus) (aka intercellular adhesion molecule 1)
B: s100a9 (mus musculus) (aka s100 calcium binding protein a9 (calgranulin b))
C: s100 calcium binding protein a9 (rattus norvegicus) (aka s100 calcium binding protein a9)
D: p8 (mus musculus) (s100 cal... | [G; H; J; P] |
<Instruct>: Given the context 'Heterodimeric S100A8/S100A9 enhanced secretion of IL-6, ICAM-1, VCAM-1 and MCP1 in AGE-albumin pretreated HUVEC in a dose dependent manner.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, s... | <Mentions>: [s100a8; s100a9; il-6; icam-1]
<Options>: A: cd51 (mus musculus) (aka integrin alpha v)
B: s100 calcium binding protein a9 (calgranulin b) (mus musculus) (aka s100 calcium binding protein a9 (calgranulin b))
C: icam1 (rattus norvegicus) (aka intercellular adhesion molecule 1)
D: il6 (homo sapiens) (aka inte... | [O; H; D; I] |
<Instruct>: Given the context 'Heterodimeric S100A8/S100A9 enhanced secretion of IL-6, ICAM-1, VCAM-1 and MCP1 in AGE-albumin pretreated HUVEC in a dose dependent manner.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, s... | <Mentions>: [s100a8; s100a9; il-6; icam-1]
<Options>: A: vcam1 (homo sapiens) (aka vascular cell adhesion molecule 1)
B: s100 calcium binding protein a8 (rattus norvegicus) (aka s100 calcium binding protein a8)
C: s100a9 (mus musculus) (aka s100 calcium binding protein a9 (calgranulin b))
D: intercellular adhesion mole... | [J; F; M; D] |
<Instruct>: Given the context 'Heterodimeric S100A8/S100A9 enhanced secretion of IL-6, ICAM-1, VCAM-1 and MCP1 in AGE-albumin pretreated HUVEC in a dose dependent manner.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, s... | <Mentions>: [vcam-1; mcp1]
<Options>: A: mcp1 (ovis aries) (aka mast cell proteinase-1)
B: icam-1 (mus musculus) (aka intercellular adhesion molecule 1)
C: vcam-1 (mus musculus) (aka vascular cell adhesion molecule 1)
D: platelet/endothelial cell adhesion molecule 1 (mus musculus) (aka platelet/endothelial cell adhesio... | [F; H] |
<Instruct>: Given the context 'Heterodimeric S100A8/S100A9 enhanced secretion of IL-6, ICAM-1, VCAM-1 and MCP1 in AGE-albumin pretreated HUVEC in a dose dependent manner.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, s... | <Mentions>: [vcam-1; mcp1]
<Options>: A: platelet/endothelial cell adhesion molecule 1 (mus musculus) (aka platelet/endothelial cell adhesion molecule 1)
B: vcam-1 (ovis aries) (aka vascular cell adhesion protein 1)
C: ccl1 (homo sapiens) (aka c-c motif chemokine ligand 1)
D: mcp-1 (mus musculus) (c-c motif chemokine l... | [J; F] |
<Instruct>: Given the context 'Heterodimeric S100A8/S100A9 enhanced secretion of IL-6, ICAM-1, VCAM-1 and MCP1 in AGE-albumin pretreated HUVEC in a dose dependent manner.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, s... | <Mentions>: [vcam-1; mcp1]
<Options>: A: vcam-1 (mus musculus) (aka vascular cell adhesion molecule 1)
B: mcp-1 (mus musculus) (c-c motif chemokine ligand 2 (mus musculus)) (aka c-c motif chemokine ligand 2)
C: mcp-1 (homo sapiens) (aka c-c motif chemokine ligand 2)
D: vcam1 (rattus norvegicus) (aka vascular cell adhes... | [I; C] |
<Instruct>: Given the context 'These effects could not be detected after stimulation with the homodimeric proteins S100A8, S100A9, S100A1 and S100B.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [s100a8; s100a9; s100a1; s100b]
<Options>: A: s100 protein, beta polypeptide, neural (mus musculus) (aka s100 protein, beta polypeptide, neural)
B: cal (mus musculus) (s100 calcium binding protein a11 (mus musculus)) (aka s100 calcium binding protein a11)
C: s100a1 (rattus norvegicus) (s100 calcium binding ... | [G; I; L; M] |
<Instruct>: Given the context 'These effects could not be detected after stimulation with the homodimeric proteins S100A8, S100A9, S100A1 and S100B.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [s100a8; s100a9; s100a1; s100b]
<Options>: A: cal (mus musculus) (s100 calcium binding protein a11 (mus musculus)) (aka s100 calcium binding protein a11)
B: s100 protein, beta polypeptide, neural (mus musculus) (aka s100 protein, beta polypeptide, neural)
C: s100 calcium binding protein a1 (mus musculus) (a... | [K; M; D; N] |
<Instruct>: Given the context 'These effects could not be detected after stimulation with the homodimeric proteins S100A8, S100A9, S100A1 and S100B.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [s100a8; s100a9; s100a1; s100b]
<Options>: A: s100beta (homo sapiens) (aka s100 calcium binding protein b)
B: cal (mus musculus) (s100 calcium binding protein a11 (mus musculus)) (aka s100 calcium binding protein a11)
C: s100 calcium binding protein a8 (rattus norvegicus) (aka s100 calcium binding protein a... | [E; O; K; A] |
<Instruct>: Given the context 'These effects could not be detected after stimulation with the homodimeric proteins S100A8, S100A9, S100A1 and S100B.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [s100a8; s100a9; s100a1; s100b]
<Options>: A: s100a (mus musculus) (aka s100 calcium binding protein a1)
B: s100a8 (rattus norvegicus) (aka s100 calcium binding protein a8)
C: s100a1 (rattus norvegicus) (s100 calcium binding protein a1 (rattus norvegicus)) (aka s100 calcium binding protein a1)
D: s100-b (ho... | [N; G; L; D] |
<Instruct>: Given the context 'These effects could not be detected after stimulation with the homodimeric proteins S100A8, S100A9, S100A1 and S100B.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [s100a8; s100a9; s100a1; s100b]
<Options>: A: p8 (mus musculus) (s100 calcium binding protein a8 (calgranulin a) (mus musculus)) (aka s100 calcium binding protein a8 (calgranulin a))
B: s100 calcium binding protein b (homo sapiens) (aka s100 calcium binding protein b)
C: s100a1 (rattus norvegicus) (s100 cal... | [H; K; L; B] |
<Instruct>: Given the context 'The effects of heterodimeric S100A8/S100A9 were reduced by inhibition of the MAP-kinase pathways ERK1/2 and p38 by PD 98059 and SB 203580, respectively.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for ea... | <Mentions>: [s100a8; s100a9; p38]
<Options>: A: mrp8 (homo sapiens) (s100 calcium binding protein a8 (homo sapiens)) (aka s100 calcium binding protein a8)
B: p38mapk (mus musculus) (aka mitogen-activated protein kinase 14)
C: p38 (homo sapiens) (mitogen-activated protein kinase 1 (homo sapiens)) (aka mitogen-activated ... | [A; D; J] |
<Instruct>: Given the context 'The effects of heterodimeric S100A8/S100A9 were reduced by inhibition of the MAP-kinase pathways ERK1/2 and p38 by PD 98059 and SB 203580, respectively.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for ea... | <Mentions>: [s100a8; s100a9; p38]
<Options>: A: p38a (mus musculus) (aka mitogen-activated protein kinase 14)
B: p38 (rattus norvegicus) (aka mitogen activated protein kinase 14)
C: p14 (mus musculus) (s100 calcium binding protein a9 (calgranulin b) (mus musculus)) (aka s100 calcium binding protein a9 (calgranulin b))
... | [F; I; H] |
<Instruct>: Given the context 'The effects of heterodimeric S100A8/S100A9 were reduced by inhibition of the MAP-kinase pathways ERK1/2 and p38 by PD 98059 and SB 203580, respectively.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for ea... | <Mentions>: [s100a8; s100a9; p38]
<Options>: A: s100 calcium binding protein a8 (calgranulin a) (mus musculus) (aka s100 calcium binding protein a8 (calgranulin a))
B: s100a8 (homo sapiens) (aka s100 calcium binding protein a8)
C: s100 calcium binding protein a9 (calgranulin b) (mus musculus) (aka s100 calcium binding ... | [B; E; F] |
<Instruct>: Given the context 'The heterodimeric S100A8/S100A9 might therefore play a hitherto unknown role in triggering atherosclerosis in diabetes and renal failure, pathophysiological entities associated with a high AGE burden.', select the correct biomedical concept for each mention using the provided options. In ... | <Mentions>: [s100a8; s100a9]
<Options>: A: s100a9 (homo sapiens) (aka s100 calcium binding protein a9)
B: p8 (homo sapiens) (s100 calcium binding protein a8 (homo sapiens)) (aka s100 calcium binding protein a8)
C: s100 calcium binding protein a8 (rattus norvegicus) (aka s100 calcium binding protein a8)
D: s100a8 (mus m... | [B; A] |
<Instruct>: Given the context 'The heterodimeric S100A8/S100A9 might therefore play a hitherto unknown role in triggering atherosclerosis in diabetes and renal failure, pathophysiological entities associated with a high AGE burden.', select the correct biomedical concept for each mention using the provided options. In ... | <Mentions>: [s100a8; s100a9]
<Options>: A: s100a9 (mus musculus) (aka s100 calcium binding protein a9 (calgranulin b))
B: s100a8 (rattus norvegicus) (aka s100 calcium binding protein a8)
C: s100 calcium binding protein a9 (homo sapiens) (aka s100 calcium binding protein a9)
D: s100 calcium binding protein a8 (homo sapi... | [D; C] |
<Instruct>: Given the context 'Thus, blocking heterodimeric S100A8/S100A9 might represent a novel therapeutic modality in treating atherosclerosis.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [s100a8; s100a9]
<Options>: A: s100-a8 (homo sapiens) (aka s100 calcium binding protein a8)
B: s100a8 (rattus norvegicus) (aka s100 calcium binding protein a8)
C: s100a9 (homo sapiens) (aka s100 calcium binding protein a9)
D: s100 calcium binding protein a9 (rattus norvegicus) (aka s100 calcium binding prot... | [A; C] |
<Instruct>: Given the context 'Thus, blocking heterodimeric S100A8/S100A9 might represent a novel therapeutic modality in treating atherosclerosis.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [s100a8; s100a9]
<Options>: A: s100a8 (rattus norvegicus) (aka s100 calcium binding protein a8)
B: s100 calcium binding protein a9 (calgranulin b) (mus musculus) (aka s100 calcium binding protein a9 (calgranulin b))
C: p8 (homo sapiens) (s100 calcium binding protein a8 (homo sapiens)) (aka s100 calcium bind... | [C; D] |
<Instruct>: Given the context 'Human growth hormone (GH1) gene polymorphism map in a normal-statured adult population.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [growth hormone; gh1]
<Options>: A: gh1 (rattus norvegicus) (growth hormone 1 (rattus norvegicus)) (aka growth hormone 1)
B: gh (mus musculus) (aka growth hormone)
C: growth hormone (ovis aries) (aka growth hormone)
D: gh1 (homo sapiens) (aka growth hormone 1)
E: gh1b1 (mus musculus) (aka growth hormone)
F:... | [D; I] |
<Instruct>: Given the context 'Human growth hormone (GH1) gene polymorphism map in a normal-statured adult population.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [growth hormone; gh1]
<Options>: A: gh (mus musculus) (aka growth hormone)
B: gh (rattus norvegicus) (aka growth hormone 1)
C: gh1 (cricetulus griseus) (aka growth hormone 1)
D: gh1 (rattus norvegicus) (gonadotropin releasing hormone receptor (rattus norvegicus)) (aka gonadotropin releasing hormone receptor... | [H; H] |
<Instruct>: Given the context 'OBJECTIVE: GH1 gene presents a complex map of single nucleotide polymorphisms (SNPs) in the entire promoter, coding and noncoding regions.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, se... | <Mentions>: [gh1]
<Options>: A: gh (mus musculus) (aka growth hormone)
B: growth hormone 1 (homo sapiens) (aka growth hormone 1)
C: gh1 (danio rerio) (aka growth hormone 1)
D: gh1 (rattus norvegicus) (gonadotropin releasing hormone receptor (rattus norvegicus)) (aka gonadotropin releasing hormone receptor)
E: gh1 (ratt... | [B] |
<Instruct>: Given the context 'OBJECTIVE: GH1 gene presents a complex map of single nucleotide polymorphisms (SNPs) in the entire promoter, coding and noncoding regions.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, se... | <Mentions>: [gh1]
<Options>: A: gh1 (rattus norvegicus) (growth hormone 1 (rattus norvegicus)) (aka growth hormone 1)
B: gh1 (danio rerio) (aka growth hormone 1)
C: gh1 (rattus norvegicus) (gonadotropin releasing hormone receptor (rattus norvegicus)) (aka gonadotropin releasing hormone receptor)
D: gh (mus musculus) (a... | [E] |
<Instruct>: Given the context 'The aim of the study was to establish the complete map of GH1 gene SNPs in our control normal population and to analyse its association with adult height.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for ... | <Mentions>: [gh1]
<Options>: A: gh1 (ovis aries) (aka growth hormone)
B: gh1 (danio rerio) (aka growth hormone 1)
C: gh1 (cricetulus griseus) (aka growth hormone 1)
D: gh (homo sapiens) (growth hormone 1 (homo sapiens)) (aka growth hormone 1)
E: gh (mus musculus) (aka growth hormone)
F: None of the above. | [D] |
<Instruct>: Given the context 'DESIGN, SUBJECTS AND MEASUREMENTS: A systematic GH1 gene analysis was designed in a control population of 307 adults of both sexes with height normally distributed within normal range for the same population: -2 standard deviation scores (SDS) to +2 SDS.', select the correct biomedical co... | <Mentions>: [gh1]
<Options>: A: gh1 (danio rerio) (aka growth hormone 1)
B: gh1 (cricetulus griseus) (aka growth hormone 1)
C: gh (homo sapiens) (growth hormone 1 (homo sapiens)) (aka growth hormone 1)
D: gh1 (rattus norvegicus) (growth hormone 1 (rattus norvegicus)) (aka growth hormone 1)
E: gh1 (ovis aries) (aka grow... | [C] |
<Instruct>: Given the context 'This study established the GH1 gene sequence variation map in a normal adult height control population confirming the high density of SNPs in a relatively small gene.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct optio... | <Mentions>: [gh1]
<Options>: A: gh1 (ovis aries) (aka growth hormone)
B: growth hormone 1 (homo sapiens) (aka growth hormone 1)
C: gh1 (rattus norvegicus) (gonadotropin releasing hormone receptor (rattus norvegicus)) (aka gonadotropin releasing hormone receptor)
D: gh1 (rattus norvegicus) (growth hormone 1 (rattus norv... | [B] |
<Instruct>: Given the context 'Systematic GH1 gene analysis in patients with growth delay and suspected GH deficiency/insufficiency will clarify whether different SNP frequencies and/or the presence of different sequence changes may be associated with phenotypes in them.', select the correct biomedical concept for each... | <Mentions>: [gh1]
<Options>: A: growth hormone 1 (homo sapiens) (aka growth hormone 1)
B: gh1 (cricetulus griseus) (aka growth hormone 1)
C: gh1 (ovis aries) (aka growth hormone)
D: gh1 (rattus norvegicus) (growth hormone 1 (rattus norvegicus)) (aka growth hormone 1)
E: gh (mus musculus) (aka growth hormone)
F: None of... | [A] |
<Instruct>: Given the context 'The genes in which SNPs were analyzed include CCR2, CCR5, COX1, COX2, CRP, CSF1, CSF2, IFNG, IL1A, IL1B, IL2, IL4, IL6, IL8, IL10, IL13, IL18, LTA, MPO, NOS2A, NOS3, PPARD, PPARG, PPARGC1 and TNF.', select the correct biomedical concept for each mention using the provided options. In the ... | <Mentions>: [ccr2; ccr5; cox1; cox2]
<Options>: A: cox (homo sapiens) (cytochrome c oxidase subunit 5a (homo sapiens)) (aka cytochrome c oxidase subunit 5a)
B: ccr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
C: cox2 (saccharomyces cerevisiae s288c) (aka cytochrome c oxidase subunit 2)
D: ccr5 (homo sapiens) (a... | [B; D; O; Q] |
<Instruct>: Given the context 'The genes in which SNPs were analyzed include CCR2, CCR5, COX1, COX2, CRP, CSF1, CSF2, IFNG, IL1A, IL1B, IL2, IL4, IL6, IL8, IL10, IL13, IL18, LTA, MPO, NOS2A, NOS3, PPARD, PPARG, PPARGC1 and TNF.', select the correct biomedical concept for each mention using the provided options. In the ... | <Mentions>: [ccr2; ccr5; cox1; cox2]
<Options>: A: cox-2 (rattus norvegicus) (aka prostaglandin-endoperoxide synthase 2)
B: cox1 (homo sapiens) (prostaglandin-endoperoxide synthase 1 (homo sapiens)) (aka prostaglandin-endoperoxide synthase 1)
C: cox1 (caenorhabditis elegans) (aka cytochrome c oxidase subunit i)
D: ccr2... | [D; L; B; F] |
<Instruct>: Given the context 'The genes in which SNPs were analyzed include CCR2, CCR5, COX1, COX2, CRP, CSF1, CSF2, IFNG, IL1A, IL1B, IL2, IL4, IL6, IL8, IL10, IL13, IL18, LTA, MPO, NOS2A, NOS3, PPARD, PPARG, PPARGC1 and TNF.', select the correct biomedical concept for each mention using the provided options. In the ... | <Mentions>: [ccr2; ccr5; cox1; cox2]
<Options>: A: c-c motif chemokine receptor 5 (homo sapiens) (aka c-c motif chemokine receptor 5)
B: cox (homo sapiens) (cytochrome c oxidase subunit 5a (homo sapiens)) (aka cytochrome c oxidase subunit 5a)
C: ccr5 (homo sapiens) (aka c-c motif chemokine receptor 5)
D: cox1 (saccharo... | [Q; A; F; E] |
<Instruct>: Given the context 'The genes in which SNPs were analyzed include CCR2, CCR5, COX1, COX2, CRP, CSF1, CSF2, IFNG, IL1A, IL1B, IL2, IL4, IL6, IL8, IL10, IL13, IL18, LTA, MPO, NOS2A, NOS3, PPARD, PPARG, PPARGC1 and TNF.', select the correct biomedical concept for each mention using the provided options. In the ... | <Mentions>: [ccr2; ccr5; cox1; cox2]
<Options>: A: cox2 (homo sapiens) (mitochondrially encoded cytochrome c oxidase ii (homo sapiens)) (aka mitochondrially encoded cytochrome c oxidase ii)
B: cox2 (rattus norvegicus) (cytochrome c oxidase ii, mitochondrial (rattus norvegicus)) (aka cytochrome c oxidase ii, mitochondri... | [H; I; G; R] |
<Instruct>: Given the context 'The genes in which SNPs were analyzed include CCR2, CCR5, COX1, COX2, CRP, CSF1, CSF2, IFNG, IL1A, IL1B, IL2, IL4, IL6, IL8, IL10, IL13, IL18, LTA, MPO, NOS2A, NOS3, PPARD, PPARG, PPARGC1 and TNF.', select the correct biomedical concept for each mention using the provided options. In the ... | <Mentions>: [ccr2; ccr5; cox1; cox2]
<Options>: A: ccr5 (ovis aries) (aka c-c motif chemokine receptor 5)
B: ccr2b (homo sapiens) (aka c-c motif chemokine receptor 2)
C: ccr5 (rattus norvegicus) (aka c-c motif chemokine receptor 5)
D: cox2 (rattus norvegicus) (cytochrome c oxidase ii, mitochondrial (rattus norvegicus))... | [B; Q; R; N] |
<Instruct>: Given the context 'The genes in which SNPs were analyzed include CCR2, CCR5, COX1, COX2, CRP, CSF1, CSF2, IFNG, IL1A, IL1B, IL2, IL4, IL6, IL8, IL10, IL13, IL18, LTA, MPO, NOS2A, NOS3, PPARD, PPARG, PPARGC1 and TNF.', select the correct biomedical concept for each mention using the provided options. In the ... | <Mentions>: [crp; csf1; csf2; ifng]
<Options>: A: colony stimulating factor 1 (rattus norvegicus) (aka colony stimulating factor 1)
B: crp1 (mus musculus) (ccaat/enhancer binding protein epsilon (mus musculus)) (aka ccaat/enhancer binding protein epsilon)
C: csf2 (mus musculus) (aka colony stimulating factor 2 (granulo... | [M; E; L; S] |
<Instruct>: Given the context 'The genes in which SNPs were analyzed include CCR2, CCR5, COX1, COX2, CRP, CSF1, CSF2, IFNG, IL1A, IL1B, IL2, IL4, IL6, IL8, IL10, IL13, IL18, LTA, MPO, NOS2A, NOS3, PPARD, PPARG, PPARGC1 and TNF.', select the correct biomedical concept for each mention using the provided options. In the ... | <Mentions>: [crp; csf1; csf2; ifng]
<Options>: A: crp (homo sapiens) (c-reactive protein (homo sapiens)) (aka c-reactive protein)
B: csf2 (mus musculus) (aka colony stimulating factor 2 (granulocyte-macrophage))
C: crp (homo sapiens) (cysteine and glycine rich protein 1 (homo sapiens)) (aka cysteine and glycine rich pr... | [A; H; E; S] |
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