Datasets:
Derify
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ReactionSmiles

Dataset card Data Studio Files
xet
 Community
1
smiles
stringlengths
15
6.12k
source_id
int64
1
5
IC1=CC=C(C=C1)Br.CC(C)(C)S(=O)N=C1COC1>O.C1CCCO1.C(CCC)[Li].C(C)(=O)OCC.[Cl-].[NH4+]>BrC1=CC=C(C=C1)C1(COC1)NS(=O)C(C)(C)C
3
C1(=CC=C(C=C1)CCCO)C1=CC=CC=C1>>C1(=CC=C(C=C1)CCC=O)C1=CC=CC=C1
5
BrC=1C=CC(=NC1)C(=O)O.NC=1C=C(C(=NC1)Cl)C1(COCC(N1)=S)CF>>ClC1=C(C=C(C=N1)NC(=O)C1=NC=C(C=C1)Br)C1(NC(COC1)=S)CF
5
COC(C(C)N1N=CC(=C1)C=1C=NC(=C(C1)OC(C)C1=C(C(=CC=C1Cl)F)Cl)N)=O>>NC1=C(C=C(C=N1)C=1C=NN(C1)C(C(=O)O)C)OC(C)C1=C(C(=CC=C1Cl)F)Cl
5
BrC=1C=CC(=NC1)OC(C)(C)C>O1CCOCC1.B1(OC(C(O1)(C)C)(C)C)B2OC(C(O2)(C)C)(C)C.C1=CC=C(C=C1)P([C-]2C=CC=C2)C3=CC=CC=C3.C1=CC=C(C=C1)P([C-]2C=CC=C2)C3=CC=CC=C3.Cl[Pd]Cl.[Fe+2].C(C)(=O)[O-].[K+]>C(C)(C)(C)OC1=NC=C(C=C1)B1OC(C(O1)(C)C)(C)C
3
N([C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](C(C)C)C(=O)O)C(=O)C.N1C(C(=O)NC2CC(OC2OCC2=CC=CC=C2)=O)CCCC1>>C(C)(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](C(C)C)C(=O)N1C(C(=O)NC2CC(OC2OCC2=CC=CC=C2)=O)CCCC1
5
CC1=NC2=CC=CC(=C2C=C1)N1CCNCC1.ClCC(=O)C=1C(=CC2=C(NC(CO2)=O)C1)F>CC#N.C(C)(C)N(C(C)C)CC>FC1=CC2=C(NC(CO2)=O)C=C1C(CN1CCN(CC1)C1=C2C=CC(=NC2=CC=C1)C)=O
3
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[C:10]1([CH:16]2[CH2:20][CH2:19][NH:18][CH2:17]2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][N:18]2[CH2:19][CH2:20][CH:16]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[CH2:17]2)=[CH:4][CH:3]=1
1
[CH2:1]([C@@H:8]1[CH2:12][O:11][C:10](=[O:13])[N:9]1[C:14](=[O:38])[C@@H:15]([C:23]1[CH:28]=[CH:27][C:26]([S:29]([CH:32]2[CH2:34][CH2:33]2)(=[O:31])=[O:30])=[C:25]([CH:35]2[CH2:37][CH2:36]2)[CH:24]=1)[CH2:16][C@H:17]1[CH2:21][CH2:20][C:19](=[O:22])[CH2:18]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:39][C:40]([CH3:45])([CH2:43]O)[CH2:41][OH:42].C1(C)C=CC(S([O-])(=O)=O)=CC=1.[NH+]1C=CC=CC=1.C(=O)(O)[O-].[Na+]>C1(C)C=CC=CC=1>[CH2:1]([C@@H:8]1[CH2:12][O:11][C:10](=[O:13])[N:9]1[C:14](=[O:38])[C@@H:15]([C:23]1[CH:28]=[CH:27][C:26]([S:29]([CH:32]2[CH2:34][CH2:33]2)(=[O:31])=[O:30])=[C:25]([CH:35]2[CH2:37][CH2:36]2)[CH:24]=1)[CH2:16][C@H:17]1[CH2:21][CH2:20][C:19]2([O:42][CH2:41][C:40]([CH3:45])([CH3:43])[CH2:39][O:22]2)[CH2:18]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1
1
[C:1]([O:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15](=O)[CH3:16])=[CH:9][CH:8]=1)(=[O:3])[CH3:2].[NH2:18][CH2:19][CH:20]([C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[CH:23]=1)[OH:21].C1C=CC=CC=1.C([BH3-])#N.[Na+]>C(O)(C)C>[C:1]([O:4][CH2:5][CH2:6][C:7]1[CH:8]=[CH:9][C:10]([O:13][CH2:14][CH:15]([NH:18][CH2:19][CH:20]([C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[CH:23]=2)[OH:21])[CH3:16])=[CH:11][CH:12]=1)(=[O:3])[CH3:2]
1
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[N:3]=1.[CH2:15]([O:22][C:23]1[CH:24]=[C:25]([CH:27]=[CH:28][CH:29]=1)[NH2:26])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH2:15]([O:22][C:23]1[CH:24]=[C:25]([CH:27]=[CH:28][CH:29]=1)[NH:26][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[N:3]=1)[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1
1
OCC1=CS[C@H]2N(C1C(=O)OC(C1=CC=CC=C1)C1=CC=CC=C1)C([C@H]2NC(CC=2SC=CC2)=O)=O>ClCCl.c1ccncc1.[O-2].[O-2].[O-2].[Cr+6]>C(=O)C1=CS[C@H]2N(C1C(=O)OC(C1=CC=CC=C1)C1=CC=CC=C1)C([C@H]2NC(CC=2SC=CC2)=O)=O
3
[CH3:1][O:2][C:3](=[O:29])[CH2:4][CH2:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[C:9]([N:16]3[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]3)[CH:10]=[CH:11][CH:12]=2)[N:7]=1.FC(F)(F)C(O)=O>C(Cl)Cl.CO>[N:16]1([C:9]2[CH:10]=[CH:11][CH:12]=[C:13]3[C:8]=2[N:7]=[C:6]([CH2:5][CH2:4][C:3]([O:2][CH3:1])=[O:29])[CH:15]=[CH:14]3)[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1
2
BrCC(=O)Br.ClC=1C=CC2=C(NC(S2)=O)C1>N(C)(C)C=O.[Al](Cl)(Cl)Cl>ClC=1C(=CC2=C(NC(S2)=O)C1)C(CCl)=O
3
C(OC([NH:8][C:9]1[CH:13]=[CH:12][O:11][C:10]=1[C:14]([O:16][CH3:17])=[O:15])=O)(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[NH2:8][C:9]1[CH:13]=[CH:12][O:11][C:10]=1[C:14]([O:16][CH3:17])=[O:15]
2
ClC1=C(C=C(N)C=C1)C1=NC=CC=C1.ClC1=C(C(=O)O)C=CC(=C1)N(S(=O)(=O)C)CCOC>>ClC1=C(C(=O)NC2=CC(=C(C=C2)Cl)C2=NC=CC=C2)C=CC(=C1)N(S(=O)(=O)C)CCOC
3
SC1=CC=NC=C1.C(C1=CC=CC=C1)OC1=C(C=CC(=C1C)OCCCCBr)C(CC(C)C)=O>>C(C1=CC=CC=C1)OC1=C(C=CC(=C1C)OCCCCSC1=CC=NC=C1)C(CC(C)C)=O
5
Cl.Cl.NCC=1SC=C(N1)CC(=O)OCC>ClCCl.C(O)([O-])=O.[Na+].ClC(=O)OC1=CC=C(C=C1)[N+](=O)[O-]>[N+](=O)([O-])C1=CC=C(OC(=O)NCC=2SC=C(N2)CC(=O)OCC)C=C1
4
CS(=O)(=O)N1CCC(CC1)=O.ClC=1C=2N(C=NC1C=1C=NN(C1)C(C)OCC)N=C(N2)N>N(C)(C)C=O.C(=O)(C(F)(F)F)O.C(C)(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+].C(O)([O-])=O.[Na+]>ClC=1C=2N(C=NC1C=1C=NNC1)N=C(N2)NC2CCN(CC2)S(=O)(=O)C
3
O1C(=NC2=NC=CC=C21)N2CCN(CC2)C(=O)OC(C)(C)C>C(Cl)(Cl)(Cl)[H].ClC=1C=C(C(=O)OO)C=CC1>C(C)(C)(C)OC(=O)N1CCN(CC1)C=1OC=2C(=[N+](C=CC2)[O-])N1
3
[N:1]1([C:10]2[S:14][C:13]([C:15]([OH:17])=O)=[C:12]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[CH3:26])[CH:11]=2)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.ClC(N(C)C)=C(C)C.[CH:35]([NH2:38])([CH3:37])[CH3:36].C(N(C(C)C)CC)(C)C>ClCCl>[N:1]1([C:10]2[S:14][C:13]([C:15]([NH:38][CH:35]([CH3:37])[CH3:36])=[O:17])=[C:12]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[CH3:26])[CH:11]=2)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1
2
C1(=CC=CC=C1)C1=NSC(=N1)N1CCN(CC1)C(=O)NC=1C=C(C(=O)OC)C=CC1>C1(=CC=CC=C1)C.C1CCCO1.CC(C)C[AlH]CC(C)C>OCC=1C=C(C=CC1)NC(=O)N1CCN(CC1)C1=NC(=NS1)C1=CC=CC=C1
3
[CH2:1]([C:8]1[S:9][CH:10]=[C:11]([C:13](O)=[O:14])[N:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH2:1]([C:8]1[S:9][CH:10]=[C:11]([CH2:13][OH:14])[N:12]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1
1
[CH3:1][S:2]([O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2([C:20]3[CH:25]=[C:24]([C:26]4[CH:31]=[CH:30][CH:29]=[C:28]([O:32][CH3:33])[CH:27]=4)[CH:23]=[CH:22][N:21]=3)[C:16](=[O:17])[N:15]([CH3:18])[C:14](=S)[NH:13]2)=[CH:8][CH:7]=1)(=[O:4])=[O:3].[OH-].[NH4+:35].C(OO)(C)(C)C>CO>[CH3:1][S:2]([O:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]2([C:20]3[CH:25]=[C:24]([C:26]4[CH:31]=[CH:30][CH:29]=[C:28]([O:32][CH3:33])[CH:27]=4)[CH:23]=[CH:22][N:21]=3)[C:16](=[O:17])[N:15]([CH3:18])[C:14]([NH2:35])=[N:13]2)=[CH:10][CH:11]=1)(=[O:4])=[O:3]
2
[Cl:1][C:2]1[C:3]([N:8]2[C:12](O)([C:13]([O:15][CH3:16])=[O:14])[CH2:11][C:10]([CH2:18]O)=[N:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1.O=S(Cl)[Cl:22]>C(Cl)Cl>[Cl:22][CH2:18][C:10]1[CH:11]=[C:12]([C:13]([O:15][CH3:16])=[O:14])[N:8]([C:3]2[C:2]([Cl:1])=[CH:7][CH:6]=[CH:5][N:4]=2)[N:9]=1
1
ClC1=CC=C2C(=C(N(C2=C1C1=C2N(N=C1CN(S(=O)(=O)C)CC1=NN(C(=C1)CO)C)CCC2)C)C(=O)OCC)CCCOC2=CC(=CC1=CC(=CC=C21)F)SCC2=CC=C(C=C2)OC>c3c(P(c1ccccc1)c2ccccc2)cccc3.ClCCl.C(Br)(Br)(Br)Br>BrCC1=CC(=NN1C)CN(S(=O)(=O)C)CC=1C(=C2N(N1)CCC2)C=2C(=CC=C1C(=C(N(C21)C)C(=O)OCC)CCCOC2=CC(=CC1=CC(=CC=C21)F)SCC2=CC=C(C=C2)OC)Cl
3
CC(=CB(O)O)C.BrC=1C(N(C(=NC1CCOC)C1=C(C=CC=C1)OCC1=CC=CC=C1)CCC1=CC=CC=C1)=O>CCO[H].O1CCOCC1.C([O-])([O-])=O.[Na+].[Na+]>COCCC1=C(C(N(C(=N1)C1=C(C=CC=C1)OCC1=CC=CC=C1)CCC1=CC=CC=C1)=O)C=C(C)C
3
C([O:5][C:6]([CH2:8][C@@H:9]([CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:10]([O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:11])=[O:7])(C)(C)C>FC(F)(F)C(O)=O.ClCCl>[C:6]([CH2:8][C@@H:9]([CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)[C:10]([O:12][CH2:13][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)=[O:11])([OH:7])=[O:5]
1
ClC1=CC=C(C=C1)CCC=O.C(C)(=O)N[C@]1(CNC[C@@H]1CCCB1OC(C(O1)(C)C)(C)C)C(=O)NC(C)(C)C>>N[C@]1(CN(C[C@@H]1CCCB(O)O)CCCC1=CC=C(C=C1)Cl)C(=O)O
5
BrC1=C(C(=O)O)C=C(C=C1)[N+](=O)[O-].O=C(CNC(=O)C1=CC=C(C=C1)C1=CC=CC=C1)N1CCNCC1>N(C)(C)C=O.C(C)(C)N(C(C)C)CC.OC1=CC=CC=2NN=NC21.CCN=C=NCCCN(C)C>BrC1=C(C(=O)N2CCN(CC2)C(CNC(=O)C2=CC=C(C=C2)C2=CC=CC=C2)=O)C=C(C=C1)[N+](=O)[O-]
3
C(C)(C)(C)OC(=O)N1CCC(CC1)N1N=CC(=C1)C=1C(=C2CC[C@@H](N(C2=CC1)C(=O)OC)C)OC1=C(C=C(C=C1)Cl)C#N>>ClC1=CC(=C(OC2=C3CC[C@@H](N(C3=CC=C2C=2C=NN(C2)C2CCNCC2)C(=O)OC)C)C=C1)C#N
5
[CH:1]([N:4]1[C:8]([C:9]2[S:10][C:11]3[CH2:12][CH2:13][O:14][C:15]4[CH:22]=[C:21](B5OC(C)(C)C(C)(C)O5)[CH:20]=[CH:19][C:16]=4[C:17]=3[N:18]=2)=[N:7][C:6]([CH3:32])=[N:5]1)([CH3:3])[CH3:2].I[CH:34]1[CH2:37][O:36][CH2:35]1.Cl.N[C@@H]1CCCC[C@H]1O.C[Si](C)(C)N[Si](C)(C)C.[Na]>[Ni](I)I>[CH:1]([N:4]1[C:8]([C:9]2[S:10][C:11]3[CH2:12][CH2:13][O:14][C:15]4[CH:22]=[C:21]([CH:34]5[CH2:37][O:36][CH2:35]5)[CH:20]=[CH:19][C:16]=4[C:17]=3[N:18]=2)=[N:7][C:6]([CH3:32])=[N:5]1)([CH3:2])[CH3:3]
1
[H-].[Na+].[F:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8](=O)[C:7]2=[O:14].[Cl:15][C:16]1[CH:27]=[C:20]2[C:21](OC(=O)[NH:25][C:19]2=[CH:18][CH:17]=1)=[O:22].CO>CN(C=O)C.C(Cl)(Cl)Cl>[Cl:15][C:16]1[CH:27]=[C:20]2[C:19](=[CH:18][CH:17]=1)[N:25]=[C:8]1[C:7](=[O:14])[C:6]3[C:10]([N:9]1[C:21]2=[O:22])=[CH:11][CH:12]=[C:4]([F:3])[CH:5]=3
1
[Br:1][C:2]1[S:3][C:4]([NH:15][C:16]([C:18]2[CH:19]=[N:20][N:21]3[CH:26]=[CH:25][CH:24]=[N:23][C:22]=23)=[O:17])=[C:5]([C:7]2[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:8]=2[OH:14])[N:6]=1.C(=O)([O-])[O-].[Cs+].[Cs+].Cl[C:34]([F:39])([F:38])C([O-])=O.[Na+]>CN(C=O)C.O>[Br:1][C:2]1[S:3][C:4]([NH:15][C:16]([C:18]2[CH:19]=[N:20][N:21]3[CH:26]=[CH:25][CH:24]=[N:23][C:22]=23)=[O:17])=[C:5]([C:7]2[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:8]=2[O:14][CH:34]([F:39])[F:38])[N:6]=1
1
[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:9]=[C:8](Br)[C:7]([NH2:11])=[C:6]([F:12])[C:5]=1[NH:13][C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=1[Cl:21].[C:23](N)(C)([CH3:25])[CH3:24]>C(O)(C)C.O.CCOC(C)=O>[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:9]=[C:8]([C:23]([CH3:25])=[CH2:24])[C:7]([NH2:11])=[C:6]([F:12])[C:5]=1[NH:13][C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=1[Cl:21]
1
[CH3:1][C:2]1[N:3]=[C:4]2[S:21][CH:20]=[CH:19][N:5]2[C:6](=[O:18])[C:7]=1[C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=1.[N:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH:28]=O)[CH:23]=1.[O-]CC.[Na+]>C(O)C>[N:22]1[CH:27]=[CH:26][CH:25]=[C:24](/[CH:28]=[CH:1]/[C:2]2[N:3]=[C:4]3[S:21][CH:20]=[CH:19][N:5]3[C:6](=[O:18])[C:7]=2[C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:15])[F:16])=[CH:10][CH:9]=2)[CH:23]=1
1
[CH:1]1([NH:4][C:5]([C:7]2[CH:12]=[CH:11][C:10]([C:13]3[N:14]=[C:15]([NH:18][C:19]([C@H:21]4[NH:25][CH2:24][CH2:23][S:22]4)=[O:20])[S:16][CH:17]=3)=[CH:9][CH:8]=2)=[O:6])[CH2:3][CH2:2]1.CCN(C(C)C)C(C)C.Cl[C:36]([O:38][CH2:39][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)=[O:37]>CN(C=O)C>[CH2:39]([O:38][C:36]([N:25]1[CH2:24][CH2:23][S:22][C@H:21]1[C:19](=[O:20])[NH:18][C:15]1[S:16][CH:17]=[C:13]([C:10]2[CH:9]=[CH:8][C:7]([C:5](=[O:6])[NH:4][CH:1]3[CH2:3][CH2:2]3)=[CH:12][CH:11]=2)[N:14]=1)=[O:37])[C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1
1
FC1=C(C(=O)OCC)C(=CC=C1OC)OC>>FC1=C(C(=O)O)C(=CC=C1OC)OC
5
Br[C:2]1[CH:3]=[C:4]([C:15]([NH:17][CH2:18][C:19]2[C:20](=[O:27])[NH:21][C:22]([CH3:26])=[CH:23][C:24]=2[CH3:25])=[O:16])[C:5]2[CH:10]=[N:9][N:8]([CH:11]3[CH2:14][CH2:13][CH2:12]3)[C:6]=2[N:7]=1.[CH3:28][C:29]1([CH3:46])[CH2:34][C:33](B2OC(C)(C)C(C)(C)O2)=[CH:32][C:31]([CH3:45])([CH3:44])[NH:30]1.C([O-])([O-])=O.[Na+].[Na+].CCOC(C)=O>O1CCOCC1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH:11]1([N:8]2[C:6]3[N:7]=[C:2]([C:33]4[CH2:32][C:31]([CH3:45])([CH3:44])[NH:30][C:29]([CH3:46])([CH3:28])[CH:34]=4)[CH:3]=[C:4]([C:15]([NH:17][CH2:18][C:19]4[C:20](=[O:27])[NH:21][C:22]([CH3:26])=[CH:23][C:24]=4[CH3:25])=[O:16])[C:5]=3[CH:10]=[N:9]2)[CH2:14][CH2:13][CH2:12]1
1
[C:1]([O:5][C:6](=[O:13])[C@H:7]([CH2:9][CH:10]1[CH2:12][CH2:11]1)[NH2:8])([CH3:4])([CH3:3])[CH3:2].[CH:14](OCC#N)=[O:15]>ClCCl>[C:1]([O:5][C:6](=[O:13])[C@H:7]([CH2:9][CH:10]1[CH2:12][CH2:11]1)[NH:8][CH:14]=[O:15])([CH3:4])([CH3:2])[CH3:3]
1
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH2:8])[CH:3]=1.[N:9]1[CH:14]=[CH:13][CH:12]=[C:11](B(O)O)[CH:10]=1.C([O-])([O-])=O.[Na+].[Na+]>O1CCOCC1.CCO.O.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[N:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:2]2[N:7]=[CH:6][N:5]=[C:4]([NH2:8])[CH:3]=2)[CH:10]=1
1
COC(C1=CC(=NC=C1)CC=1C=C2C=C(C=NC2=C(C1)S(N)(=O)=O)C)=O>O.C1CCCO1.Cl.[OH-].[Na+]>CC=1C=NC2=C(C=C(C=C2C1)CC=1C=C(C(=O)O)C=CN1)S(N)(=O)=O
3
C(=O)(OC(C)(C)C)OC(=O)OC(C)(C)C.BrC=1N=C(C=2N(C1)C=CN2)NC2CC2>C1(=CC=NC=C1)N(C)C.ClCCl.c1ccncc1>BrC=1N=C(C=2N(C1)C=CN2)N(C(OC(C)(C)C)=O)C2CC2
3
C(C)(=O)O.C(=N)N.ClC=1C=C(OC(C(=O)OCC)C(=O)OCC)C=C(C1)C#N>O.CO[H].C[O-].[Na+]>ClC=1C=C(C#N)C=C(C1)OC1=C(N=CNC1=O)O
3
C(C(C)C)[C@H]1C(N[C@H](CN1)CC(C)C)=O.FC=1C=C(C=CC1F)C1=CC(=NO1)C(=O)O>>FC=1C=C(C=CC1F)C1=CC(=NO1)C(=O)N1[C@H](C(N[C@H](C1)CC(C)C)=O)CC(C)C
5
Br[CH2:2][C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][N:4]=1.[CH3:11][NH:12][C:13]([C:15]1[C:16](=[O:32])[C:17]([C:22]2[CH:27]=[CH:26][N:25]=[C:24]([C:28]([F:31])([F:30])[F:29])[CH:23]=2)=[C:18]([CH3:21])[NH:19][CH:20]=1)=[O:14]>>[CH3:11][NH:12][C:13]([C:15]1[C:16](=[O:32])[C:17]([C:22]2[CH:27]=[CH:26][N:25]=[C:24]([C:28]([F:31])([F:30])[F:29])[CH:23]=2)=[C:18]([CH3:21])[N:19]([CH2:2][C:3]2[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][N:4]=2)[CH:20]=1)=[O:14]
1
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([NH:10][C:11]([O:15][CH3:16])=[N:12]2)=[C:8]([NH2:17])[N:7]=1)[CH2:2][CH2:3][CH3:4].[Br:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]CCBr>>[Br:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][N:12]1[C:11]([O:15][CH3:16])=[N:10][C:9]2[C:13]1=[N:14][C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])=[N:7][C:8]=2[NH2:17]
2
[CH3:1][O:2][C@H:3]1[CH2:7][CH2:6][CH2:5][C@H:4]1[O:8][C:9]1[C:14]2[C:15]([O:18][CH2:19][CH:20]3[CH2:25][CH2:24][N:23]([CH2:26][C:27]4([OH:33])[CH2:32][CH2:31][O:30][CH2:29][CH2:28]4)[CH2:22][CH2:21]3)=[N:16][O:17][C:13]=2[CH:12]=[CH:11][CH:10]=1.[C:34]([OH:39])(=[O:38])[C:35]([OH:37])=[O:36]>C(OCC)C>[C:34]([OH:39])(=[O:38])[C:35]([OH:37])=[O:36].[CH3:1][O:2][C@H:3]1[CH2:7][CH2:6][CH2:5][C@H:4]1[O:8][C:9]1[C:14]2[C:15]([O:18][CH2:19][CH:20]3[CH2:21][CH2:22][N:23]([CH2:26][C:27]4([OH:33])[CH2:32][CH2:31][O:30][CH2:29][CH2:28]4)[CH2:24][CH2:25]3)=[N:16][O:17][C:13]=2[CH:12]=[CH:11][CH:10]=1
1
COC(=O)C=1S(N(C2=NC=CN=C2C1O)CC(F)F)(=O)=O>>FC(CN1S(CC(C2=NC=CN=C12)=O)(=O)=O)F
5
C[N:2](C)[C@H:3]([C:11]([OH:13])=[O:12])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.CCN(CC)CC.NCCCCN>CC#N>[NH2:2][C@H:3]([C:11]([OH:13])=[O:12])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1
1
Br[C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4]1([C:15]3=[CH:16][C:17]4[O:21][CH2:20][O:19][C:18]=4[CH:22]=[C:14]3[O:13][CH2:12]1)[C:5](=O)[NH:6]2.BrC1C=CC=C2C=1[C:26]1([C:42]3=CC4OCOC=4C=[C:41]3[O:40][CH2:39]1)C(=O)N2CCCCC.O1C=CC(B(O)O)=C1.CN(C)C1N=CC(B(O)O)=CC=1>>[O:40]1[CH:41]=[CH:42][C:26]([C:2]2[CH:10]=[CH:9][CH:8]=[C:7]3[C:3]=2[C:4]2([C:15]4=[CH:16][C:17]5[O:21][CH2:20][O:19][C:18]=5[CH:22]=[C:14]4[O:13][CH2:12]2)[CH:5]=[N:6]3)=[CH:39]1
2
C(C)(C)O.ClC1=CC=C(C(=O)N2CC(N(C3=C(C2)C=CC(=C3)O)CC3=CC=C(C=C3)C(=O)N3CC=CC3)=O)C=C1>>ClC1=CC=C(C(=O)N2CC(N(C3=C(C2)C=CC(=C3)OC(C)C)CC3=CC=C(C=C3)C(=O)N3CC=CC3)=O)C=C1
5
[N:1]([CH2:4][CH:5]1[O:9][C:8](=[O:10])[N:7]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:6]1)=[N+]=[N-].[H][H]>[Pd].CO>[NH2:1][CH2:4][C@H:5]1[O:9][C:8](=[O:10])[N:7]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:6]1
1
[CH2:1](Cl)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[I:9][C:10]1[C:11]([OH:20])=[C:12]([O:18][CH3:19])[CH:13]=[C:14]([CH:17]=1)[CH:15]=[O:16].C(=O)([O-])[O-].[K+].[K+].C(OC(=O)C)C.CCCCCC>CN(C=O)C>[I:9][C:10]1[CH:17]=[C:14]([CH:13]=[C:12]([O:18][CH3:19])[C:11]=1[O:20][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH:15]=[O:16]
1
[NH2:1][CH2:2][C:3]1[N:8]=[C:7]([S:9][CH3:10])[N:6]=[C:5]([S:11][CH3:12])[CH:4]=1.[C:13](OC(=O)C)(=[O:15])[CH3:14]>>[C:13]([NH:1][CH2:2][C:3]1[N:8]=[C:7]([S:9][CH3:10])[N:6]=[C:5]([S:11][CH3:12])[CH:4]=1)(=[O:15])[CH3:14]
1
C(C(C)=C)Cl.C(C)OC1=C(C=CC=C1)O>N(C)(C)C=O.O.C([O-])([O-])=O.[K+].[K+].[I-].[K+]>C(C)OC1=C(C=CC=C1)OCC(=C)C
3
C(#N)C=1C=C(C=O)C=CC1F.COC1=C(C=CC(=C1)C)O>>C(=O)C=1C=CC(=C(C#N)C1)OC1=C(C=C(C=C1)C)OC
5
BrC1=CC2=NC=CC(=C2S1)OC1=C(C=C(C=C1)[N+](=O)[O-])F.CN(CCCOC1=NC=C(C=C1)B1OC(C(O1)(C)C)(C)C)C>>FC1=C(OC2=C3C(=NC=C2)C=C(S3)C=3C=CC(=NC3)OCCCN(C)C)C=CC(=C1)[N+](=O)[O-]
5
S1C(=CC=C1)B(O)O.IC1=C(C=C(C(=O)N2CC=3N(CC4=C2C=CC=C4)C(=CC3)C(=O)NCC=3C=NC=CC3)C=C1)C>>CC=1C=C(C(=O)N2CC=3N(CC4=C2C=CC=C4)C(=CC3)C(=O)NCC=3C=NC=CC3)C=CC1C=1SC=CC1
5
CC1=CC(=NN1)OC1=CC(=CC=C1)C(F)(F)F>CCN(CC)CC.C(C)(=O)OCC.ClC(=O)OC(Cl)(Cl)Cl>C(C)ONC(=O)N1N=C(C=C1C)OC1=CC(=CC=C1)C(F)(F)F
3
NCCC(=O)O.COC(=O)C=1C(=C2C=C(C(N(C2=C(N1)C1=CN=CS1)CC1=CC=CC=C1)=O)C1=CC=CC=C1)O>C[O-].[Na+].C(O)([O-])=O.[Na+]>C(C1=CC=CC=C1)N1C(C(=CC2=C(C(=NC(=C12)C1=CN=CS1)C(=O)NCCC(=O)O)O)C1=CC=CC=C1)=O
3
N(=[N+]=[N-])C[C@H]1N(C(O[C@@H]1C(=O)OC)(C)C)C(=O)OC(C)(C)C>CO[H].[OH-].[K+]>N(=[N+]=[N-])C[C@H]1N(C(O[C@@H]1C(=O)O)(C)C)C(=O)OC(C)(C)C
3
CC1(OB(OC1(C)C)C=1C=C2CC(NC2=CC1)=O)C.BrC1=CC=2C3=C(C=NC2C=C1)N(C(N3C=3C(=NN(C3)C)C)=O)C>>CN1N=C(C(=C1)N1C(N(C=2C=NC=3C=CC(=CC3C21)C=2C=C1CC(NC1=CC2)=O)C)=O)C
3
BrC1=NC(=NC=C1)Cl>[Cu]I.C1(=CC=CC=C1)C.CCO[H].C(=O)([O-])[O-].[Cs+].[Cs+].N1=CC=CC2=CC=C3C=CC=NC3=C12>ClC1=NC=C(C=N1)OCC
3
CC1([C@@H](C[C@@H]1C(=O)O[C@@H]1C([C@@H]2CC[C@]3([C@@]4(CC[C@@]5([C@@H]([C@H]4CC[C@@H]3[C@]2(CC1)C)[C@@H](CC5)C5(CC5)C)NC[C@H]([C@H](C)F)N5CCS(CC5)(=O)=O)C)C)(C)C)C(=O)OCC5=CC=CC=C5)C>C1CCCO1.CO[H].[OH-].[K+]>O=S1(CCN(CC1)[C@H](CN[C@]12[C@@H]([C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC1)C)C)(C)C)OC(=O)[C@@H]1C([C@@H](C1)C(=O)O)(C)C)C)[C@@H](CC2)C2(CC2)C)[C@H](C)F)=O
3
OC1=CC=C(C=O)C=C1.CN(S(=O)(=O)Cl)C>>C(=O)C1=CC=C(C=C1)OS(N(C)C)(=O)=O
5
S(=O)(=O)(O)O.[CH3:6][C:7]1[N:12]=[C:11]([C:13]([OH:15])=[O:14])[CH:10]=[CH:9][CH:8]=1.[C:16](=O)([O-])[O-].[Na+].[Na+]>CO>[CH3:6][C:7]1[N:12]=[C:11]([C:13]([O:15][CH3:16])=[O:14])[CH:10]=[CH:9][CH:8]=1
1
C([O:3][C:4]([C:6]1[S:7][C:8]2[CH2:9][CH2:10][O:11][C:12]3[CH:19]=[C:18]([Br:20])[CH:17]=[CH:16][C:13]=3[C:14]=2[N:15]=1)=[O:5])C.CO.O.[OH-].[Na+]>C1COCC1>[Br:20][C:18]1[CH:17]=[CH:16][C:13]2[C:14]3[N:15]=[C:6]([C:4]([OH:5])=[O:3])[S:7][C:8]=3[CH2:9][CH2:10][O:11][C:12]=2[CH:19]=1
1
[OH:1][C:2]1[C:3]([C:8]([OH:10])=[O:9])=[N:4][CH:5]=[CH:6][CH:7]=1.S(=O)(=O)(O)O.[CH2:16](O)[CH3:17]>C1C=CC=CC=1>[OH:1][C:2]1[C:3]([C:8]([O:10][CH2:16][CH3:17])=[O:9])=[N:4][CH:5]=[CH:6][CH:7]=1
1
Cl[C:2]1[N:3]([CH2:10][C@:11]([OH:36])([CH3:35])[CH2:12][N:13]2[CH2:18][CH2:17][N:16]([C:19]([O:21][CH2:22][CH:23]=[CH:24][C:25]3[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][CH:26]=3)=[O:20])[CH2:15][CH2:14]2)[CH:4]=[C:5]([N+:7]([O-:9])=[O:8])[N:6]=1.[H-].[Na+].C(OCC)(=O)C.O>CN(C=O)C>[CH3:35][C@@:11]1([CH2:12][N:13]2[CH2:18][CH2:17][N:16]([C:19]([O:21][CH2:22][CH:23]=[CH:24][C:25]3[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][CH:26]=3)=[O:20])[CH2:15][CH2:14]2)[O:36][C:2]2=[N:6][C:5]([N+:7]([O-:9])=[O:8])=[CH:4][N:3]2[CH2:10]1
1
N#CBr.FC(C=1C=C(CNCC=2C=C3C(=NC2N(CC2CC2)CC2CC2)N(C(=N3)C)C)C=C(C1)C(F)(F)F)(F)F>CO[H].C(O)([O-])=O.[Na+]>C1(CC1)CN(C1=C(C=C2C(=N1)N(C(=N2)C)C)CN(C#N)CC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)CC2CC2
3
[OH:1][C:2]1[C:16]([C:17]([CH3:20])([CH3:19])[CH3:18])=[CH:15][C:5]([CH2:6][NH:7][N:8]2[CH:12]=[CH:11][N:10]=[C:9]2SC)=[CH:4][C:3]=1[C:21]([CH3:24])([CH3:23])[CH3:22].[BH4-].[Na+].N>C(O)C.[Ni](Cl)Cl>[OH:1][C:2]1[C:16]([C:17]([CH3:19])([CH3:18])[CH3:20])=[CH:15][C:5]([CH2:6][NH:7][N:8]2[CH:12]=[CH:11][N:10]=[CH:9]2)=[CH:4][C:3]=1[C:21]([CH3:24])([CH3:23])[CH3:22]
1
[C-]#N.[Zn+2].[C-]#N.BrC=1C=C2CN(C(NC2=CC1)=O)C1CCNCC1>>O=C1NC2=CC=C(C=C2CN1C1CCNCC1)C#N
5
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].C([Li])(C)(C)C.CCCCC.[B:25](OC)([O:28]C)[O:26]C>O1CCCC1>[CH2:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[B:25]([OH:28])[OH:26])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]
1
C1(CC1)B(O)O.ClC1=NC=2C(=CC=C(C2C(=C1CC1=CC=C(C=C1)N1N=CC=C1)C)O)F>O.O1CCOCC1.C(=O)([O-])[O-].[Cs+].[Cs+]>C1(CC1)C1=NC=2C(=CC=C(C2C(=C1CC1=CC=C(C=C1)N1N=CC=C1)C)O)F
3
[CH:1]([C:3]1[N:4]=[CH:5][C:6]([C:9]([O:11][CH3:12])=[O:10])=[N:7][CH:8]=1)=[O:2].[BH4-].[Na+].CO.Cl>C1COCC1.[Cl-].[Na+].O>[OH:2][CH2:1][C:3]1[N:4]=[CH:5][C:6]([C:9]([O:11][CH3:12])=[O:10])=[N:7][CH:8]=1
1
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[NH:9][CH:10]=[C:11]([CH:13]=[O:14])[N:12]=1.[H-].[Na+].C1OCCOCCOCCOCCOC1.[CH3:32][N:33]1[C:37]([S:38](Cl)(=[O:40])=[O:39])=[CH:36][CH:35]=[N:34]1>O1CCCC1.C(=O)([O-])O.[Na+]>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]([S:38]([C:37]2[N:33]([CH3:32])[N:34]=[CH:35][CH:36]=2)(=[O:40])=[O:39])[CH:10]=[C:11]([CH:13]=[O:14])[N:12]=1
2
FC1=CC=C(C=C1)[C@H](C)N.ClC1=C(C(=O)O)C=C(C=N1)C(F)(F)F>N(C)(C)C=O.C(C)(C)N(C(C)C)CC.F[P-](F)(F)(F)(F)F.N1(N=NC2=C1N=CC=C2)OC(=[N+](C)C)N(C)C>ClC1=C(C(=O)N[C@@H](C)C2=CC=C(C=C2)F)C=C(C=N1)C(F)(F)F
3
CC1=C(C=C(C(=O)O)C=C1)B1OC(C(O1)(C)C)(C)C.BrC=1C=C2CN(C(C2=CC1)=O)C1=CC=CC=C1>C([O-])([O-])=O.[Na+].[Na+].COCCOC.c1ccc(cc1)[P](c2ccccc2)(c3ccccc3)[Pd]([P](c4ccccc4)(c5ccccc5)c6ccccc6)([P](c7ccccc7)(c8ccccc8)c9ccccc9)[P](c1ccccc1)(c1ccccc1)c1ccccc1>CC1=C(C=C(C(=O)O)C=C1)C=1C=C2CN(C(C2=CC1)=O)C1=CC=CC=C1
3
C1(CCCCC1)C(OC1=CC=C(C(=O)OC)C=C1)C=1SC(=CC1C)C1=CC=C(C=C1)C(F)(F)F>C1CCCO1.CO[H].[OH-].[Na+]>C1(CCCCC1)C(OC1=CC=C(C(=O)O)C=C1)C=1SC(=CC1C)C1=CC=C(C=C1)C(F)(F)F
3
S(N1[CH2:20][C:19](=[O:21])[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)C1)(C1C=CC(C)=CC=1)(=O)=O.[CH2:22]([O:24][P:25]([C:30]([P:32](=[O:39])([O:36][CH2:37][CH3:38])[O:33][CH2:34][CH3:35])=[CH2:31])(=[O:29])[O:26][CH2:27][CH3:28])[CH3:23].[CH2:40]1[CH2:50][CH2:49][N:48]2[C:43](=NCC[CH2:47]2)[CH2:42][CH2:41]1.C1C[O:54]CC1>C(OCC)(=O)C.CCOCC>[CH2:37]([O:36][P:32]([CH:30]([P:25](=[O:29])([O:26][CH2:27][CH3:28])[O:24][CH2:22][CH3:23])[CH2:31][CH:20]([C:19](=[O:21])[C:18]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)[C:47]([NH:48][C:43]1[CH:42]=[CH:41][CH:40]=[CH:50][CH:49]=1)=[O:54])(=[O:39])[O:33][CH2:34][CH3:35])[CH3:38]
1
ClC=1C=CC(=C(C1)[C@@]1(C(NC2=CC(=CC=C12)C(F)(F)F)=O)F)OC.ClC=1C=CC(=C(C1)[C@@]1(C(N(C2=CC(=CC=C12)C(F)(F)F)C(=O)Cl)=O)F)OC.ClC(=O)O.OCCCOP(OC(C)(C)C)(OC(C)(C)C)=O>>P(=O)(O)(O)OC(COC(=O)N1C([C@@](C2=CC=C(C=C12)C(F)(F)F)(F)C1=C(C=CC(=C1)Cl)OC)=O)C
5
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:13][C:12]3[CH:14]=[C:15]([O:18]C(C)C)[CH:16]=[CH:17][C:11]=3[CH:10]=2)=[CH:5][CH:4]=1.B(Cl)(Cl)Cl.CO>C(Cl)Cl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:13][C:12]3[CH:14]=[C:15]([OH:18])[CH:16]=[CH:17][C:11]=3[CH:10]=2)=[CH:5][CH:4]=1
1
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([OH:16])=O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[CH3:21][NH:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([S:30][CH3:31])[CH:25]=1>>[Cl:20][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([N:22]([CH3:21])[CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([S:30][CH3:31])[CH:25]=2)=[O:16])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]
1
ClC=1C(=C(NC2=NC=NC3=CC(=C(C=C23)O[C@@H]2CC(N(C2)C)C(=O)OC)OC)C=CC1)F>>ClC=1C(=C(NC2=NC=NC3=CC(=C(C=C23)O[C@@H]2CC(N(C2)C)C(=O)O)OC)C=CC1)F
5
C(C=C)OC1=C(C=C(C=C1)CCl)C>>C(C=C)OC1=CC(=C(C=C1)CS)C
5
BrC1=C(C=2CCCC2C=C1)O>CO[H].C(C)(C)N(C(C)C)CC.B(O)(O)O.Nc1ccccc1-c2ccccc2[Pd]Cl.CCCCP([C@@]34C[C@@H]5C[C@@H](C[C@@H](C5)C3)C4)[C@@]67C[C@@H]8C[C@@H](C[C@@H](C8)C6)C7>OC1=C2CCCC2=CC=C1B(O)O
3
C(C#C)OC1OCCCC1.C1OC2(CC=3CC[C@H]4[C@@H]5CCC([C@@]5(C)CC=C4C3CC2)=O)OC1>C1CCCO1.C(CCC)[Li].[Cl-].[NH4+]>C1OC2(CC=3CC[C@H]4[C@@H]5CC[C@]([C@@]5(C)CC=C4C3CC2)(C#CCOC2OCCCC2)O)OC1
3
C(C)OC1=C(C(C1=O)=O)NC=1C(=C(C(=O)N2[C@H](CCC2)C(=O)OC(C)(C)C)C=CC1)O>C(C)OCC.C(=O)(C(F)(F)F)O>C(C)OC1=C(C(C1=O)=O)NC=1C(=C(C(=O)N2[C@H](CCC2)C(=O)O)C=CC1)O
3
C(C1=CC=CC=C1)OC1=NC(=NC(=C1)C#N)C>>CC1=NC(=CC(=N1)C(N)=NO)OCC1=CC=CC=C1
5
ClCCO.IC1=CC=C(C=C1)N1CCNCC1>>IC1=CC=C(C=C1)N1CCN(CC1)CCO
5
N[C:2]1[C:3]2[C:30]([CH3:32])([CH3:31])[C:29](=[O:33])[NH:28][C:4]=2[N:5]=[C:6]([C:8]2[N:9]=[C:10]([CH2:18][C:19]3[C:24]([F:25])=[CH:23][CH:22]=[C:21]([F:26])[C:20]=3[F:27])[N:11]3[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=23)[N:7]=1.[I-:34].[Cs+].II.N(OCCC(C)C)=O>COCCOC.[Cu]I>[Cl:17][C:15]1[CH:14]=[CH:13][C:12]2[N:11]([C:10]([CH2:18][C:19]3[C:24]([F:25])=[CH:23][CH:22]=[C:21]([F:26])[C:20]=3[F:27])=[N:9][C:8]=2[C:6]2[N:7]=[C:2]([I:34])[C:3]3[C:30]([CH3:32])([CH3:31])[C:29](=[O:33])[NH:28][C:4]=3[N:5]=2)[CH:16]=1
1
S(=O)(=O)(O)O.[C:6]1([C@H:16]([NH:18][CH2:19]/[CH:20]=[CH:21]/[C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([F:31])([F:30])[F:29])[CH:23]=2)[CH3:17])[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]=[CH:8][CH:7]=1.[ClH:32]>O.CC(O)C>[ClH:32].[C:6]1([C@H:16]([NH:18][CH2:19]/[CH:20]=[CH:21]/[C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([F:29])([F:30])[F:31])[CH:23]=2)[CH3:17])[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]=[CH:8][CH:7]=1
2
[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:26]=[CH:25][C:9]([O:10][C:11]2[CH:16]=[C:15]([CH3:17])[C:14]([C:18]3[N:19]=[C:20]([NH2:23])[S:21][CH:22]=3)=[C:13]([CH3:24])[CH:12]=2)=[CH:8][CH:7]=1.C([N:29]([CH2:32][CH3:33])[CH2:30][CH3:31])C.[F:34]C1C=C(C=CN=1)C(O)=O.Cl.C(N=C=NCCCN(C)C)C.[OH:56][C:57]1[C:65]2N=NNC=2C=CC=1>C(Cl)Cl>[F:34][C:31]1[CH:30]=[N:29][CH:32]=[CH:33][C:65]=1[C:57]([NH:23][C:20]1[S:21][CH:22]=[C:18]([C:14]2[C:15]([CH3:17])=[CH:16][C:11]([O:10][C:9]3[CH:8]=[CH:7][C:6]([O:5][CH2:4][CH2:3][O:2][CH3:1])=[CH:26][CH:25]=3)=[CH:12][C:13]=2[CH3:24])[N:19]=1)=[O:56]
1
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:11])[CH2:9][CH3:10])=[CH:4][CH:3]=1.[Br:12]Br>C(Cl)(Cl)Cl.[Cl-].[Al+3].[Cl-].[Cl-]>[Br:12][CH:9]([CH3:10])[C:8]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)=[O:11]
1
C(C)N1N=C(C=C1C=1C=C2C=C(NC2=CC1)C1CCN(CC1)C(=O)OCCCC)C(F)(F)F>>C(C)N1N=C(C=C1C=1C=C2C=C(NC2=CC1)C1CCNCC1)C(F)(F)F
5
BrC=1C=CC(=NC1)C1(CCC1)C(=O)NC1=CC=C(C=C1)F>O1CCOCC1.B1(OC(C(O1)(C)C)(C)C)B2OC(C(O2)(C)C)(C)C.C(C)(=O)[O-].[K+].[Pd](Cl)Cl.C(C)(C)(C)P([C-]1C=CC=C1)C(C)(C)C.[C-]1(C=CC=C1)P(C(C)(C)C)C(C)(C)C.[Fe+2]>FC1=CC=C(C=C1)NC(=O)C1(CCC1)C1=NC=C(C=C1)B1OC(C(O1)(C)C)(C)C
3
N1=CC(C(C=C1)=O)C(=O)N.C(C)(=O)OC1[C@@H](OC(C2=CC=CC=C2)=O)[C@@H](OC(C2=CC=CC=C2)=O)[C@@H](O1)COC(C1=CC=CC=C1)=O>>C(C1=CC=CC=C1)(=O)O[C@@H]1[C@H](O[C@H]([C@@H]1OC(C1=CC=CC=C1)=O)COC(C1=CC=CC=C1)=O)N1C=C(C(C=C1)=O)C(=O)N
5
COC=1C=C(OC2CN(CC2)C)C=CC1[N+](=O)[O-]>>COC1=C(N)C=CC(=C1)OC1CN(CC1)C
5
[F:1][C:2]([C:5]1[O:9][C:8]([CH2:10][N:11]2[CH:15]=[C:14]([NH2:16])[CH:13]=[N:12]2)=[CH:7][CH:6]=1)([F:4])[CH3:3].[Cl:17][C:18]1[CH:19]=[C:20]([C:24]2[S:28][CH:27]=[N:26][C:25]=2[C:29](O)=[O:30])[CH:21]=[CH:22][CH:23]=1>>[F:4][C:2]([C:5]1[O:9][C:8]([CH2:10][N:11]2[CH:15]=[C:14]([NH:16][C:29]([C:25]3[N:26]=[CH:27][S:28][C:24]=3[C:20]3[CH:21]=[CH:22][CH:23]=[C:18]([Cl:17])[CH:19]=3)=[O:30])[CH:13]=[N:12]2)=[CH:7][CH:6]=1)([F:1])[CH3:3]
1