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ReactionSmiles

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xet
Community
1
smiles
stringlengths
15
6.12k
source_id
int64
1
5
BrC1=C(C=C(C=C1)C1(O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H](O1)COC(C)=O)COC1=CC=CC=C1>>O(C1=CC=CC=C1)CC1=C(C#N)C=CC(=C1)C1(O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H](O1)COC(C)=O
5
[CH2:1](Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O:9]1[C:13]2[CH:14]=[CH:15][C:16]([C:18]3[O:22][C:21]([SH:23])=[N:20][N:19]=3)=[CH:17][C:12]=2[O:11][CH2:10]1.C(N(CC)CC)C.[OH-].[Na+]>O.C(O)C>[O:9]1[C:13]2[CH:14]=[CH:15][C:16]([C:18]3[O:22][C:21]([S:23][CH2:1][C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)=[N:20][N:19]=3)=[CH:17][C:12]=2[O:11][CH2:10]1
1
[C:1]([NH:24][CH2:25][CH2:26][S:27][S:28][CH2:29][CH2:30][NH:31]C(=O)OC(C)(C)C)(=[O:23])[CH2:2][CH2:3]/[CH:4]=[CH:5]\[CH2:6]/[CH:7]=[CH:8]\[CH2:9]/[CH:10]=[CH:11]\[CH2:12]/[CH:13]=[CH:14]\[CH2:15]/[CH:16]=[CH:17]\[CH2:18]/[CH:19]=[CH:20]\[CH2:21][CH3:22].Cl.C([O-])([O-])=O.[Na+].[Na+]>CCOC(C)=O>[NH2:31][CH2:30][CH2:29][S:28][S:27][CH2:26][CH2:25][NH:24][C:1](=[O:23])[CH2:2][CH2:3]/[CH:4]=[CH:5]\[CH2:6]/[CH:7]=[CH:8]\[CH2:9]/[CH:10]=[CH:11]\[CH2:12]/[CH:13]=[CH:14]\[CH2:15]/[CH:16]=[CH:17]\[CH2:18]/[CH:19]=[CH:20]\[CH2:21][CH3:22]
2
C(C)(=O)OC(C)=O.CC(CC=1N=C(N(C1)C(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1)CC(N)C1=CC=C(C=C1)C1=NC=C(C=C1)F)(CC)C>>CC(CC=1N=C(N(C1)C(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1)CC(C1=CC=C(C=C1)C1=NC=C(C=C1)F)NC(C)=O)(CC)C
5
[CH2:1]([O:3][C:4]([C:6]1[O:10][C:9]([C:11]2(Br)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[N:8][C:7]=1[CH2:18]Br)=[O:5])[CH3:2].[NH:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1.C1CCN2C(=NCCC2)CC1>O1CCCC1>[CH2:1]([O:3][C:4]([C:6]1[O:10][C:9]([C:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH:12]=2)=[N:8][C:7]=1[CH2:18][N:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1)=[O:5])[CH3:2]
1
FC(OC1=CC=C(C=C1)N1NC(C2=CC=CC=C2C1=O)=O)(F)F>ClCCCl.P(=O)(Br)(Br)Br>BrC1=NN(C(C2=CC=CC=C12)=O)C1=CC=C(C=C1)OC(F)(F)F
3
C(C)[Si](OC1(C=CC(C=C1)=O)C(F)(F)F)(CC)CC>CCO[H].[HH].[Pd]>C(C)[Si](OC1(CCC(CC1)=O)C(F)(F)F)(CC)CC
3
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[N+:15]([O-])=O)=[C:4]([CH3:18])[CH:3]=1.[Sn]>C(O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:10]([NH2:15])=[CH:11][CH:12]=[CH:13][CH:14]=2)=[C:4]([CH3:18])[CH:3]=1
2
Cl.[CH3:2][C@@H:3]1[C:8](=[O:9])[NH:7][C:6]2[CH:10]=[C:11]([CH2:14][NH2:15])[CH:12]=[CH:13][C:5]=2[O:4]1.[F:16][C:17]([F:23])([F:22])[CH2:18][CH2:19][CH:20]=O.C(N(CC)CC)C.[BH4-].[Na+]>C(OCC)(=O)C.O.O1CCCC1.CO>[CH3:2][C@@H:3]1[C:8](=[O:9])[NH:7][C:6]2[CH:10]=[C:11]([CH2:14][NH:15][CH2:20][CH2:19][CH2:18][C:17]([F:23])([F:22])[F:16])[CH:12]=[CH:13][C:5]=2[O:4]1
2
ClC(=O)OC.C(#C)C1=CC=C(C=C1)F>>FC1=CC=C(C=C1)C#CC(=O)OC
5
Cl.CNC.ClC1=NC(=CC(=N1)C(=O)N)Cl>>ClC1=NC(=CC(=N1)C(=O)N)N(C)C
3
BrC1=C(C(=O)NC(NC=2SC3=C(N2)C=CC(=C3)S(=O)(=O)CCNC(C)C)=O)C=C(C=C1)N1C=CC=C1>>IC1=C(C(=O)NC(NC=2SC3=C(N2)C=CC(=C3)S(=O)(=O)CCNC(C)C)=O)C=C(C=C1)N1C=CC=C1
5
N1C(CC2CCCCC12)C(=O)O>C(Cl)(Cl)(Cl)[H].S(O)(O)(=O)=O>C(C)(C)(C)OC(=O)C1NC2CCCCC2C1
3
NC=1SC(=CC1C(=O)N)C1=CC=CC=C1.C[Si](C)(C)N=C=S>>NC(=S)NC=1SC(=CC1C(=O)N)C1=CC=CC=C1
5
[CH3:1][N:2]1[CH2:6][C@@H:5]([C:7]([O:9]CC2C=CC=CC=2)=[O:8])[N:4]([C:17](=[O:35])[C@@H:18]([NH:20][C@H:21]([C:30]([O:32][CH2:33][CH3:34])=[O:31])[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[CH3:19])[C:3]1=[O:36]>[Pd]>[CH3:1][N:2]1[CH2:6][C@@H:5]([C:7]([OH:9])=[O:8])[N:4]([C:17](=[O:35])[C@@H:18]([NH:20][C@H:21]([C:30]([O:32][CH2:33][CH3:34])=[O:31])[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[CH3:19])[C:3]1=[O:36]
1
C[O:2][C:3]1[CH:25]=[CH:24][C:6]([O:7][C:8]2[S:9][C:10]([C:13]3[CH:17]=[C:16]([CH:18]([NH:20][C:21](=[O:23])[CH3:22])[CH3:19])[O:15][N:14]=3)=[CH:11][N:12]=2)=[CH:5][CH:4]=1.B(Br)(Br)Br.CO>ClCCl>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([O:7][C:8]2[S:9][C:10]([C:13]3[CH:17]=[C:16]([CH:18]([NH:20][C:21](=[O:23])[CH3:22])[CH3:19])[O:15][N:14]=3)=[CH:11][N:12]=2)=[CH:24][CH:25]=1
1
[Br:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1)[NH2:5].[CH3:13][C:14](=O)[CH2:15][CH2:16][C:17](=O)[CH3:18]>C1(C)C=CC=CC=1.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>[Br:1][C:2]1[CH:3]=[C:4]([N:5]2[C:17]([CH3:18])=[CH:16][CH:15]=[C:14]2[CH3:13])[CH:6]=[C:7]([C:9]([F:10])([F:11])[F:12])[CH:8]=1
1
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:20])[C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=2)=[CH:4][C:3]=1[C:21]1[CH:26]=[C:25]([N:27]2[CH2:32][CH2:31][O:30][CH2:29][CH2:28]2)[N:24]=[C:23](S(C)(=O)=O)[N:22]=1.C1[C:40]2(C[NH:42][CH2:41]2)CO1.C(N(CC)CC)C>C1COCC1>[CH2:41]([NH:42][C:23]1[N:22]=[C:21]([C:3]2[CH:4]=[C:5]([NH:8][C:9](=[O:20])[C:10]3[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=3)[CH:6]=[CH:7][C:2]=2[CH3:1])[CH:26]=[C:25]([N:27]2[CH2:32][CH2:31][O:30][CH2:29][CH2:28]2)[N:24]=1)[CH3:40]
1
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Br[C:8]1[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=1>CC1C=CC=CC=1C.C([O-])(=O)C.[Pd+2].C([O-])(=O)C>[F:14][C:11]1[CH:12]=[CH:13][C:8]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)=[CH:9][CH:10]=1
1
ClC1=NC(=CC(=C1)[C@@H]1CN(C[C@H](O1)C=O)C(=O)OC(C)(C)C)C1=NC=NC(=C1)C(NC)=O>C1CCCO1.[F-].[Cs+].C[Si](C(F)(F)F)(C)C>ClC1=NC(=CC(=C1)[C@@H]1CN(C[C@H](O1)C(C(F)(F)F)O)C(=O)OC(C)(C)C)C1=NC=NC(=C1)C(NC)=O
3
C1(CC1)C1=CC(=C(C(=O)OC)C=C1)C>CO[H].[OH-].[Na+]>C1(CC1)C1=CC(=C(C(=O)O)C=C1)C
3
[OH:1][CH:2]([CH:8]([N:15]([CH3:23])[C:16]1[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3]([O:5]CC)=O.[CH2:24]([NH2:26])[CH3:25]>>[CH2:24]([NH:26][C:3](=[O:5])[CH:2]([OH:1])[CH:8]([N:15]([CH3:23])[C:16]1[CH:17]=[CH:18][C:19]([CH3:22])=[CH:20][CH:21]=1)[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)[CH3:25]
1
C1OC=2C=C(C=CC2O1)CCC=CCCBr.C(C)OC(CC(=O)C)=O.[Li]>N(C)(C)C=O>C(C)(=O)C(C(=O)OCC)CCC=CCCC1=CC2=C(C=C1)OCO2
3
[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[F:19])[O:5][C:6]1[C:11]([F:12])=[CH:10][C:9]([CH2:13][OH:14])=[CH:8][C:7]=1[F:15].Cl[C:21]1[CH:22]=[C:23]2[N:30]([CH3:31])[C@@H:29]([CH3:32])[CH2:28][N:24]2[C:25](=[O:27])[N:26]=1>>[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[F:19])[O:5][C:6]1[C:7]([F:15])=[CH:8][C:9]([CH2:13][O:14][C:21]2[CH:22]=[C:23]3[N:30]([CH3:31])[C@@H:29]([CH3:32])[CH2:28][N:24]3[C:25](=[O:27])[N:26]=2)=[CH:10][C:11]=1[F:12]
1
NC=1C2=C(N=C(N1)CCCC)C(=C(N2COCC2=CC=CC=C2)C)CCCCO>>NC=1C2=C(N=C(N1)CCCC)C(=C(N2COCC2=CC=CC=C2)C)CCCC=O
5
[CH:1]([CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])=[O:2].O.[CH2:13]1[CH2:17]OC[CH2:14]1>C(OCC)C.[Ti]>[CH2:14]=[CH:13][CH2:17][C@@H:1]([OH:2])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]
1
N=1C=NN2C1C=C(C=C2)OC2=C(C=C(C=C2)NC=2C1=C(N=CN2)C=CC(=N1)Cl)C.CN1CC(C1)\C=C/1\C(NCC1)=O>[Pd+2].[O-]C(=O)C.[O-]C(=O)C.C([O-])([O-])=O.[K+].[K+].O1CCOCC1.P(c2ccccc2c1c(cc(cc1C(C)C)C(C)C)C(C)C)(C3CCCCC3)C4CCCCC4>CC=1C=C(C=CC1OC1=CC=2N(C=C1)N=CN2)NC=2C1=C(N=CN2)C=CC(=N1)N1C(/C(/CC1)=C/C1CN(C1)C)=O
3
N(C1=CC=CC=C1)C1=NC(=CC(=N1)C)CC(=O)C>C1(=CC=CC=C1)C.P(=O)(Cl)(Cl)Cl.C1(=CC=CC=C1)C.O>N(C1=CC=CC=C1)C1=NC(=CC(=N1)C)C=C(C)Cl
3
CC1=C(C=CC=C1)NC(C1=CC(=C(C=C1OCC1=CC=CC=C1)OCC1=CC=CC=C1)Br)=NN>>C(C1=CC=CC=C1)OC1=C(C=C(C(=C1)OCC1=CC=CC=C1)Br)C=1N(C(=NN1)O)C1=C(C=CC=C1)C
5
C(OC)(OC)OC.NC=1C=CC2=C(OCC3=C(C2=O)C=CC(=C3)[N+](=O)[O-])C1>>N1(N=NN=C1)C=1C=CC2=C(OCC3=C(C2=O)C=CC(=C3)[N+](=O)[O-])C1
5
[O:1]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH2:14][CH2:15][C:16]([OH:18])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:19]([NH:22][NH:23][C:24](=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)([CH3:21])[CH3:20].C(N(C(C)C)CC)(C)C.C1CN([P+](Br)(N2CCCC2)N2CCCC2)CC1.F[P-](F)(F)(F)(F)F>CN(C=O)C>[CH:19]([N:22]([C:16](=[O:18])[CH2:15][CH2:14][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[O:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[NH:23][C:24](=[O:31])[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)([CH3:21])[CH3:20]
1
N1CCC1.IC1=NC(=NC(=C1)I)OC>C1CCCO1.C(C)(C)N(C(C)C)CC>N1(CCC1)C1=NC(=NC(=C1)I)OC
3
BrC=1N(C=C(N1)[N+](=O)[O-])CC(CO)C1=C(C=C(C=C1)N1C(OC(C1)CNC(C)=O)=O)F>N(C)(C)C=O.C(=O)([O-])[O-].[Cs+].[Cs+]>FC=1C=C(C=CC1C1CN2C(OC1)=NC(=C2)[N+](=O)[O-])N2C(OC(C2)CNC(C)=O)=O
3
[OH-].[Na+].[C:3]([O:7][C@@H:8]([C:15]1[C:16]([CH3:47])=[N:17][C:18]([CH3:46])=[C:19]([C:30]2[CH:35]=[CH:34][C:33]([O:36][CH2:37][CH2:38][C:39]3[CH:44]=[CH:43][C:42]([F:45])=[CH:41][CH:40]=3)=[CH:32][CH:31]=2)[C:20]=1[N:21]1[CH2:26][CH2:25][C:24]([CH2:28][CH3:29])([CH3:27])[CH2:23][CH2:22]1)[C:9]([O:11]C(C)C)=[O:10])([CH3:6])([CH3:5])[CH3:4].Cl>C(O)C>[C:3]([O:7][C@@H:8]([C:15]1[C:16]([CH3:47])=[N:17][C:18]([CH3:46])=[C:19]([C:30]2[CH:31]=[CH:32][C:33]([O:36][CH2:37][CH2:38][C:39]3[CH:44]=[CH:43][C:42]([F:45])=[CH:41][CH:40]=3)=[CH:34][CH:35]=2)[C:20]=1[N:21]1[CH2:26][CH2:25][C:24]([CH2:28][CH3:29])([CH3:27])[CH2:23][CH2:22]1)[C:9]([OH:11])=[O:10])([CH3:6])([CH3:4])[CH3:5]
1
N1C=CC=2C1=NC=C(C2)OC2=C(C(=O)OC)C=CC(=C2)N2CC1(C2)CC(C1)N1[C@@H](CN(CC1)CC1=CC(=C(C=C1)C1CC1)OC)C1=C(C=CC=C1)C(C)C>C1CCCO1.CO[H].ClCCl.[OH-].[Na+]>N1C=CC=2C1=NC=C(C2)OC2=C(C(=O)O)C=CC(=C2)N2CC1(C2)CC(C1)N1[C@@H](CN(CC1)CC1=CC(=C(C=C1)C1CC1)OC)C1=C(C=CC=C1)C(C)C
3
ClC1=C(N)C=C(C(=C1)F)C.CCC(C)=S>>ClC=1C=C(C(=C2C(=C(NC12)C)SC)C)F
5
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([SH:8])=[CH:4][CH:3]=1.[NH2:9][CH2:10][CH2:11][CH2:12]O.[C:14]([OH:18])(=O)[CH2:15][CH3:16]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:12][CH2:11][CH2:10][NH:9][C:14](=[O:18])[CH2:15][CH3:16])=[CH:4][CH:3]=1
1
O1C(=NC2=C1C=CC=C2)C2=CC=C(C(=O)OC)C=C2>>O1C(=NC2=C1C=CC=C2)C2=CC=C(CO)C=C2
5
ClC(=O)OCC1=CC=CC=C1.N[C@@H](CC(N)=O)C(=O)O>[OH-].[Na+]>C(C1=CC=CC=C1)OC(=O)N[C@@H](CC(N)=O)C(=O)O
3
C(C)(=O)C=1N2C=CC=C2C=C(C1C)C(=O)OCC>CO[H].[Na+].[BH4-]>OC(C)C=1N2C=CC=C2C=C(C1C)C(=O)OCC
3
[CH:1]1([CH2:4][N:5]2[C:10](=[O:11])[C:9]([CH2:12][OH:13])=[CH:8][C:7]([C:14]3[CH:15]=[CH:16][C:17]4[O:21][CH2:20][CH2:19][C:18]=4[CH:22]=3)=[N:6]2)[CH2:3][CH2:2]1.C(N(CC)CC)C.[CH3:30][S:31](Cl)(=[O:33])=[O:32].C(=O)([O-])O.[Na+]>C(Cl)Cl>[CH:1]1([CH2:4][N:5]2[C:10](=[O:11])[C:9]([CH2:12][O:13][S:31]([CH3:30])(=[O:33])=[O:32])=[CH:8][C:7]([C:14]3[CH:15]=[CH:16][C:17]4[O:21][CH2:20][CH2:19][C:18]=4[CH:22]=3)=[N:6]2)[CH2:3][CH2:2]1
1
ClC(C(=O)OCC)C=O.S(=O)(=O)(C1=CC=C(C)C=C1)N1C=CC2=NC(=CN=C21)N>>S(=O)(=O)(C1=CC=C(C)C=C1)N1C=CC2=C1N=CC=1N2C(=CN1)C(=O)OCC
5
C(N(CC)CC)C.[NH2:8][C:9]1[CH:10]=[N:11][C:12]2[C:17]([C:18]=1[NH:19][CH2:20][C:21]([CH3:24])([OH:23])[CH3:22])=[CH:16][CH:15]=[CH:14][CH:13]=2.[Cl:25][CH2:26][C:27](Cl)=O>ClCCl>[Cl:25][CH2:26][C:27]1[N:19]([CH2:20][C:21]([CH3:24])([OH:23])[CH3:22])[C:18]2[C:17]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[N:11]=[CH:10][C:9]=2[N:8]=1
2
CC1=C(C=O)C=CC(=C1)C.C(C)C(C(=O)OC)(P(=O)(O)O)CC>>COC(C=CC1=C(C=C(C=C1)C)C)=O
5
CCCCCCCCCCCCCCCC(=O)Cl.CC(C)/C=C/CCCCC(=O)NCC=1C=CC(=C(C1)OC)O>C1(=CC=NC=C1)N(C)C.ClCCl.CCN(CC)CC>CCCCCCCCCCCCCCCC(=O)OC1=C(C=C(C=C1)CNC(=O)CCCC/C=C/C(C)C)OC
3
C(C)(C)(C)OC(=O)N1[C@H](CC(C1)(F)F)COC>ClCCl.C(=O)(C(F)(F)F)O>FC(C(=O)O)(F)F.FC1(C[C@@H](NC1)COC)F
3
[CH2:1]([O:5][C:6]([C:8]1[N:9]=[C:10](O)[C:11]2[C:16]([C:17]=1[OH:18])=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:7])[CH2:2][CH2:3][CH3:4].P(Cl)(Cl)([Cl:22])=O>>[CH2:1]([O:5][C:6]([C:8]1[N:9]=[C:10]([Cl:22])[C:11]2[C:16]([C:17]=1[OH:18])=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:7])[CH2:2][CH2:3][CH3:4]
1
S1N=CN=C1C(=O)OCC>O.NN>S1N=CN=C1C(=O)NN
3
Cl.[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:13]=[C:12]([CH2:14][CH:15]3[CH2:19][CH2:18][CH2:17][NH:16]3)[O:11][N:10]=2)=[CH:5][CH:4]=1.C(N(CC)CC)C.[F:27][C:28]1[CH:36]=[CH:35][C:31]([C:32](Cl)=[O:33])=[CH:30][CH:29]=1.Cl>ClCCl>[F:27][C:28]1[CH:36]=[CH:35][C:31]([C:32]([N:16]2[CH2:17][CH2:18][CH2:19][CH:15]2[CH2:14][C:12]2[O:11][N:10]=[C:9]([C:6]3[CH:7]=[CH:8][C:3]([F:2])=[CH:4][CH:5]=3)[N:13]=2)=[O:33])=[CH:30][CH:29]=1
2
[C:1]([O:5][C:6]([N:8]1[C:16]2[CH:15]=[CH:14][C:13]([Cl:17])=[CH:12][C:11]=2[C:10]2[CH2:18][CH:19]([C:21]([S:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)(=[O:29])=[O:28])([C:23](OC)=[O:24])[CH3:22])[CH2:20][C:9]1=2)=[O:7])([CH3:4])([CH3:3])[CH3:2].[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[C:1]([O:5][C:6]([N:8]1[C:16]2[CH:15]=[CH:14][C:13]([Cl:17])=[CH:12][C:11]=2[C:10]2[CH2:18][CH:19]([C:21]([S:27]([C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=3)(=[O:28])=[O:29])([CH3:22])[CH2:23][OH:24])[CH2:20][C:9]1=2)=[O:7])([CH3:2])([CH3:3])[CH3:4]
1
C1(CC1)/C=C/C(=O)OCC.CN1N=CC(=C1)C1=CC=2N(C(=N1)C=1C=NNC1)C=CN2>>C1(CC1)C(CC(=O)OCC)N1N=CC(=C1)C1=NC(=CC=2N1C=CN2)C=2C=NN(C2)C
5
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[OH:9].C(=O)([O-])[O-].[K+].[K+].Cl[CH2:17][CH:18]1[O:20][CH2:19]1>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[O:9][CH2:17][CH:18]1[O:20][CH2:19]1
1
N(=C=S)C=1C=C(C(=O)OCC)C=CC1>>N(N)C(=S)NC=1C=C(C(=O)OCC)C=CC1
5
[O:1]=[C:2]1[N:14]([CH:15]2[CH2:20][CH2:19][N:18]([C:21]([NH:23][C@H:24]([CH2:28]C3C=CC4CCCCC=4C=3)[C:25](O)=[O:26])=[O:22])[CH2:17][CH2:16]2)[C:5]2[CH:6]=[N:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[C:4]=2[NH:3]1.CN(C(ON1N=N[C:49]2[CH:50]=[CH:51][CH:52]=[CH:53][C:48]1=2)=[N+](C)C)C.[B-](F)(F)(F)F.C(N([CH:67]([CH3:69])[CH3:68])C(C)C)C.[CH3:70][N:71]1[CH2:76][CH2:75][CH:74]([N:77]2[CH2:82][CH2:81][NH:80][CH2:79][CH2:78]2)[CH2:73][CH2:72]1.[C:83]([O-])([O-])=O.[K+].[K+]>C1COCC1>[CH3:70][N:71]1[CH2:72][CH2:73][CH:74]([N:77]2[CH2:82][CH2:81][N:80]([C:25](=[O:26])[C@H:24]([NH:23][C:21]([N:18]3[CH2:19][CH2:20][CH:15]([N:14]4[C:5]5[CH:6]=[N:7][C:8]6[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=6[C:4]=5[NH:3][C:2]4=[O:1])[CH2:16][CH2:17]3)=[O:22])[CH2:28][C:52]3[CH:51]=[CH:50][C:49]4[CH2:68][CH2:67][CH2:69][CH2:83][C:48]=4[CH:53]=3)[CH2:79][CH2:78]2)[CH2:75][CH2:76]1
1
[N:1]([CH2:4][CH:5]1[CH2:9][CH:8]([NH:10]C(OC(C)(C)C)=O)[CH:7]=[CH:6]1)=[N+:2]=[N-:3]>C(O)(C(F)(F)F)=O.C(Cl)Cl>[N:1]([CH2:4][CH:5]1[CH2:9][CH:8]([NH2:10])[CH:7]=[CH:6]1)=[N+:2]=[N-:3]
1
COC1=CC2=C(NC(CCC2)=O)C=C1>C1CCCO1.O1CCOCC1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>COC1=CC2=C(NCCCC2)C=C1
3
C([Si](C)(C)[O:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14](=O)[CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:10][CH:9]=1)(C)(C)C.[NH2:25][C:26]1[C:31]([CH:32]=O)=[CH:30][N:29]=[CH:28][CH:27]=1.[OH-].[Na+]>C(O)C>[C:16]1([C:15]2[C:14]([C:11]3[CH:10]=[CH:9][C:8]([CH2:7][OH:6])=[CH:13][CH:12]=3)=[N:25][C:26]3[C:31]([CH:32]=2)=[CH:30][N:29]=[CH:28][CH:27]=3)[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1
1
FC1=C(N(CC2=CC=C(C=C2)OC)C2=CN=CC(=N2)C(CO)(CC)CC)C=CC(=C1)F>>BrC=1C(=NC(=CN1)N(C1=C(C=C(C=C1)F)F)CC1=CC=C(C=C1)OC)C(CO)(CC)CC
5
C(C(C)C)=O.CC(CCN1C(S[C@H](C1=O)CC(N1CCC(CC1)N1C(NC2=C(CC1)C=CC=C2)=O)=O)C2=CN=C(S2)C2CCNCC2)(C)C>ClCCl.C(C)(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+]>CC(CCN1C(S[C@H](C1=O)CC(N1CCC(CC1)N1C(NC2=C(CC1)C=CC=C2)=O)=O)C2=CN=C(S2)C2CCN(CC2)CC(C)C)(C)C
3
BrC1=CC=C(C2=C(C=CC=C12)Br)C(=O)O>>BrC1=CC=CC2=C(C=CC=C12)Br.BrC=1C=CC=2C(NC3=CC=CC1C23)=O
5
CN1CCNCC1.OC1=C2C(C=C(OC2=CC(=C1O)O)C1=CC=CC=C1)=O>CO[H]>OC1=C2C(C=C(OC2=C(C(=C1O)O)CN1CCN(CC1)C)C1=CC=CC=C1)=O
3
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[N:7]1[C:15]2[C:10](=[CH:11][C:12]([C:16]3[N:20]=[CH:19][N:18]([C:21]([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[N:17]=3)=[CH:13][CH:14]=2)[C:9]([C:40]2[CH:41]=[C:42]([CH:47]=[CH:48][CH:49]=2)[C:43](OC)=[O:44])=[N:8]1.[OH-].[Li+].[CH3:52][C:53]([CH3:57])([CH3:56])[CH2:54][NH2:55].O.ON1C2C=CC=CC=2N=N1.Cl.CN(C)CCCN=C=NCC>O1CCCC1.O1CCCC1.O>[CH3:52][C:53]([CH3:57])([CH3:56])[CH2:54][NH:55][C:43]([C:42]1[CH:47]=[CH:48][CH:49]=[C:40]([C:9]2[C:10]3[C:15](=[CH:14][CH:13]=[C:12]([C:16]4[N:20]=[CH:19][N:18]([C:21]([C:28]5[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=5)([C:34]5[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=5)[C:22]5[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=5)[N:17]=4)[CH:11]=3)[N:7]([CH:2]3[CH2:3][CH2:4][CH2:5][CH2:6][O:1]3)[N:8]=2)[CH:41]=1)=[O:44]
2
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[N:12]([C:15]1[CH:24]=[CH:23][CH:22]=[CH:21][C:16]=1[C:17](OC)=[O:18])=[C:13]=[S:14]>CO.C(N(CC)CC)C>[O:18]=[C:17]1[C:16]2[C:15](=[CH:24][CH:23]=[CH:22][CH:21]=2)[NH:12][C:13](=[S:14])[N:1]1[C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]
2
C(C)(C)(C)[Si](C)(C)Cl.BrC=1C=C2CCC(C2=C(C1)F)O>N(C)(C)C=O.O.c1cnc[nH]1>BrC=1C=C2CCC(C2=C(C1)F)O[Si](C)(C)C(C)(C)C
3
FC1=CC=C2C(=CNC2=C1)C=1C=C2C=NN(C2=CC1)CCC(=O)O>>FC1=CC=C2C(=CNC2=C1)C=1C=C2C=NN(C2=CC1)CCC(=O)N1CCN(CC1)C(=O)OC(C)(C)C
5
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([C:12]2[CH:34]=[CH:33][C:15]([O:16][C:17]3[CH:26]=[C:25]4[C:20]([CH:21]([C:27]([O:29]C)=[O:28])[CH2:22][CH2:23][O:24]4)=[CH:19][C:18]=3[C:31]#[N:32])=[CH:14][CH:13]=2)=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8].[OH-].[Na+].O.CO>C1COCC1.Cl.C(OCC)(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([C:12]2[CH:34]=[CH:33][C:15]([O:16][C:17]3[CH:26]=[C:25]4[C:20]([CH:21]([C:27]([OH:29])=[O:28])[CH2:22][CH2:23][O:24]4)=[CH:19][C:18]=3[C:31]#[N:32])=[CH:14][CH:13]=2)=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8]
1
[CH2:1]([O:3][C:4](=[O:16])[C:5]([O:8][C:9]1[CH:10]=[N:11][C:12]([NH2:15])=[CH:13][CH:14]=1)([CH3:7])[CH3:6])[CH3:2].Br[C:18]1[C:19](=[O:26])[N:20]([CH3:25])[N:21]=[C:22]([Cl:24])[CH:23]=1.C([O-])([O-])=O.[Cs+].[Cs+].CC1(C)C2C(=C(P(C3C=CC=CC=3)C3C=CC=CC=3)C=CC=2)OC2C(P(C3C=CC=CC=3)C3C=CC=CC=3)=CC=CC1=2>O1CCOCC1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[CH2:1]([O:3][C:4](=[O:16])[C:5]([O:8][C:9]1[CH:10]=[N:11][C:12]([NH:15][C:18]2[C:19](=[O:26])[N:20]([CH3:25])[N:21]=[C:22]([Cl:24])[CH:23]=2)=[CH:13][CH:14]=1)([CH3:7])[CH3:6])[CH3:2]
2
C(=O)(OC(C)(C)C)NCCC(=O)O.N1N=C(C2=CC=CC=C12)/C=C/C1=CC=C(C(=O)N2CCNCC2)C=C1>>Cl.Cl.NCCC(=O)N1CCN(CC1)C(C1=CC=C(C=C1)\C=C\C1=NNC2=CC=CC=C12)=O
5
C(#N)C1=NC=CC=C1.SC1=C(C(=O)O)C=CC(=C1)C(=O)O>>O=C1N=C(SC2=C1C=CC(=C2)C(=O)O)C2=NC=CC=C2
5
Cl.Cl.[CH2:3]([N:5]([CH2:12][CH3:13])[CH:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)[CH3:4]>O.[OH-].[Na+]>[CH2:12]([N:5]([CH2:3][CH3:4])[CH:6]1[CH2:7][CH2:8][NH:9][CH2:10][CH2:11]1)[CH3:13]
1
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[OH:8][C@H:9]1[C@H:15]2[CH2:16][N:11]([C:12]3[CH:29]=[CH:28][C:27]([C:30]4[CH:35]=[CH:34][CH:33]=[C:32]([C:36]([F:39])([F:38])[F:37])[CH:31]=4)=[N:26][C:13]=3[N:14]2[C:17]([NH:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=2)=[O:18])[CH2:10]1.CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C1=CC=CC=2)=O.C([O-])(O)=O.[Na+]>C(Cl)Cl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[O:8]=[C:9]1[C@H:15]2[CH2:16][N:11]([C:12]3[CH:29]=[CH:28][C:27]([C:30]4[CH:35]=[CH:34][CH:33]=[C:32]([C:36]([F:39])([F:38])[F:37])[CH:31]=4)=[N:26][C:13]=3[N:14]2[C:17]([NH:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=2)=[O:18])[CH2:10]1
2
Cl.Cl.Cl.[CH3:4][O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[CH:12]=[C:11]([C:16]1[CH:21]=[CH:20][N:19]=[C:18]([NH:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH3:31])[CH:25]=3)[N:17]=1)[CH:10]=[C:9]2[N:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1.Br[CH2:39][CH2:40][CH2:41][OH:42].C(=O)([O-])[O-].[K+].[K+].C(#N)C>O>[CH3:4][O:5][C:6]1[CH:7]=[C:8]2[C:13]([CH:12]=[C:11]([C:16]3[CH:21]=[CH:20][N:19]=[C:18]([NH:22][CH2:23][C:24]4[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH3:31])[CH:25]=4)[N:17]=3)[CH:10]=[C:9]2[N:32]2[CH2:33][CH2:34][N:35]([CH2:39][CH2:40][CH2:41][OH:42])[CH2:36][CH2:37]2)=[CH:14][CH:15]=1
1
[OH:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][CH3:10])=[N:6][CH:7]=1.[H-].[Na+].[CH2:13](Br)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.O.C(=O)([O-])O.[Na+]>O1CCCC1.C(N(CC)CC)C.CS(C)=O>[CH2:13]([O:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][CH3:10])=[N:6][CH:7]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1
1
CC=1N=CSC1.CC(C)(C1=CC=CC=C1)N1CCC(CC1)(C#N)NC1=CC=CC=C1>C1CCCO1.C(CCC)[Li]>CC(C)(C1=CC=CC=C1)N1CCC(CC1)(C=1SC=C(N1)C)NC1=CC=CC=C1
3
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[N:10]([CH2:12][CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][CH:22]([O:27][C:28]2[CH:37]=[CH:36][C:35]3[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=3)[CH:29]=2)[C:23]([O:25]C)=[O:24])=[CH:17][CH:16]=1)[CH3:11]>CO>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[N:10]([CH2:12][CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][CH:22]([O:27][C:28]2[CH:37]=[CH:36][C:35]3[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=3)[CH:29]=2)[C:23]([OH:25])=[O:24])=[CH:17][CH:16]=1)[CH3:11]
1
BrC1=C(SC=C1)C(C)=O>CN1C(CCC1)=O.[Cu+].[C-]#N>C(C)(=O)C=1SC=CC1C#N
3
Br[CH:2]1[CH2:11][CH2:10][C:9]2[C:8]([O:12][CH2:13][C:14]([O:16]CC)=[O:15])=[CH:7][CH:6]=[CH:5][C:4]=2[C:3]1=O.[C:20]1([CH:26]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[NH:27][C:28]([NH2:30])=[S:29])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C(N(CC)CC)C.[OH-].[Na+]>O.O1CCCC1.CO.C(O)C>[C:20]1([CH:26]([NH:27][C:28]2[S:29][C:2]3[CH2:11][CH2:10][C:9]4[C:4](=[CH:5][CH:6]=[CH:7][C:8]=4[O:12][CH2:13][C:14]([OH:16])=[O:15])[C:3]=3[N:30]=2)[C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1
1
ClC1=NC=C(C(=C1)Cl)C>CO[H].[OH-].[Na+]>ClC1=NC=C(C(=C1)OC)C
3
C(=O)(O)C1=CC2=C(N1)C(=C(S2)Cl)Cl.Cl.C1(=CC=CC=C1)C1(OCCO1)CN>ClCCl.C(C)(C)N(C(C)C)CC.OC1=CC=CC=2NN=NC21.CCN=C=NCCCN(C)C>ClC1=C(C=2NC(=CC2S1)C(NCC1(OCCO1)C1=CC=CC=C1)=O)Cl
3
C(C)(C)(C)C1CC(C(CC1)=O)CC#C>>C(C)(C)(C)C1CC(\C(\CC1)=N/O)CC#C
5
C(N(CC)CC)C.C1(O[C:15](=[O:31])[NH:16][C:17]2[CH:22]=[C:21]([C:23]([CH3:26])([CH3:25])[CH3:24])[CH:20]=[C:19]([CH2:27][OH:28])[C:18]=2[O:29][CH3:30])C=CC=CC=1.[NH2:32][C:33]1[C:42]2[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=2)[C:36]([O:43][C:44]2[CH:49]=[CH:48][N:47]=[C:46]([NH:50][C:51]3[CH:52]=[C:53]([CH:67]=[C:68]([C:70]#[CH:71])[CH:69]=3)[C:54]([NH:56][CH2:57][CH2:58][O:59][CH2:60][CH2:61][O:62][CH2:63][CH2:64][O:65][CH3:66])=[O:55])[CH:45]=2)=[CH:35][CH:34]=1>C(OC(C)C)(=O)C.C1COCC1>[C:23]([C:21]1[CH:20]=[C:19]([CH2:27][OH:28])[C:18]([O:29][CH3:30])=[C:17]([NH:16][C:15](=[O:31])[NH:32][C:33]2[C:42]3[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=3)[C:36]([O:43][C:44]3[CH:49]=[CH:48][N:47]=[C:46]([NH:50][C:51]4[CH:52]=[C:53]([CH:67]=[C:68]([C:70]#[CH:71])[CH:69]=4)[C:54]([NH:56][CH2:57][CH2:58][O:59][CH2:60][CH2:61][O:62][CH2:63][CH2:64][O:65][CH3:66])=[O:55])[CH:45]=3)=[CH:35][CH:34]=2)[CH:22]=1)([CH3:24])([CH3:25])[CH3:26]
2
[H-].[Na+].ClC1C=C(N)C(I)=CN=1.S(OC[C@H]1OCCN(C(OC(C)(C)C)=O)C1)(C1C=CC(C)=CC=1)(=O)=O.[Cl:37][C:38]1[CH:43]=[C:42]([NH:44][CH2:45][C@H:46]2[O:51][CH2:50][CH2:49][N:48]([C:52]([O:54][C:55]([CH3:58])([CH3:57])[CH3:56])=[O:53])[CH2:47]2)[C:41](I)=[CH:40][N:39]=1.C(=O)([O-])[O-].[Na+].[Na+].[CH3:66][O:67][C:68]1[CH:73]=[CH:72][C:71](B(O)O)=[CH:70][CH:69]=1>CN(C=O)C.C(#N)C.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.O>[Cl:37][C:38]1[CH:43]=[C:42]([NH:44][CH2:45][C@@H:46]2[O:51][CH2:50][CH2:49][N:48]([C:52]([O:54][C:55]([CH3:58])([CH3:57])[CH3:56])=[O:53])[CH2:47]2)[C:41]([C:71]2[CH:72]=[CH:73][C:68]([O:67][CH3:66])=[CH:69][CH:70]=2)=[CH:40][N:39]=1
1
[NH:1]1[C:5]2=[N:6][CH:7]=[C:8]([O:10][C:11]3[CH:32]=[C:31]([N:33]4[CH2:38][CH2:37][N:36]([CH2:39][C:40]5[CH2:45][CH2:44][C:43]([CH3:47])([CH3:46])[CH2:42][C:41]=5[C:48]5[CH:53]=[CH:52][C:51]([Cl:54])=[CH:50][CH:49]=5)[CH2:35][CH2:34]4)[CH:30]=[CH:29][C:12]=3[C:13]([NH:15][S:16]([C:19]3[CH:24]=[CH:23][C:22](Cl)=[C:21]([N+:26]([O-:28])=[O:27])[CH:20]=3)(=[O:18])=[O:17])=[O:14])[CH:9]=[C:4]2[CH:3]=[CH:2]1.[O:55]1[CH2:60][CH2:59][CH:58]([N:61]2[CH2:64][CH:63]([NH2:65])[CH2:62]2)[CH2:57][CH2:56]1.C(N(CC)CC)C.CS(C)=O>O1CCOCC1.O>[Cl:54][C:51]1[CH:52]=[CH:53][C:48]([C:41]2[CH2:42][C:43]([CH3:47])([CH3:46])[CH2:44][CH2:45][C:40]=2[CH2:39][N:36]2[CH2:37][CH2:38][N:33]([C:31]3[CH:30]=[CH:29][C:12]([C:13]([NH:15][S:16]([C:19]4[CH:24]=[CH:23][C:22]([NH:65][CH:63]5[CH2:62][N:61]([CH:58]6[CH2:59][CH2:60][O:55][CH2:56][CH2:57]6)[CH2:64]5)=[C:21]([N+:26]([O-:28])=[O:27])[CH:20]=4)(=[O:17])=[O:18])=[O:14])=[C:11]([O:10][C:8]4[CH:9]=[C:4]5[CH:3]=[CH:2][NH:1][C:5]5=[N:6][CH:7]=4)[CH:32]=3)[CH2:34][CH2:35]2)=[CH:49][CH:50]=1
1
C(C)OC(=O)C1CCC(CC1)O[Si](C)(C)C(C)(C)C>>[Si](C)(C)(C(C)(C)C)OC1CCC(CC1)C(=O)N(C)OC
5
COCC(C1=CC=C(C=C1)OC(F)(F)F)NC(=O)N1C2=C(NC(C1)=O)C(=CC=N2)C(=O)O>O.C1CCCO1.[Na+].[BH4-].CCN(CC)CC.C(C(C)C)OC(=O)Cl>OCC1=CC=NC=2N(CC(NC21)=O)C(=O)NC(COC)C2=CC=C(C=C2)OC(F)(F)F
3
[H-].[CH2:2]([Al+]CC(C)C)C(C)C.[C:11]([C:13]1[CH:14]=[C:15]([CH:19]([N:25]2[CH:29]=[C:28]([C:30]3[C:31]4[CH:38]=[CH:37][N:36]([CH2:39][O:40][CH2:41][CH2:42][Si:43]([CH3:46])([CH3:45])[CH3:44])[C:32]=4[N:33]=[CH:34][N:35]=3)[CH:27]=[N:26]2)[CH2:20][C:21](OC)=O)[CH:16]=[CH:17][CH:18]=1)#[N:12].C(Cl)Cl.CO.C(=O)([O-])[O-].[K+].[K+].C/C(/[O-])=C(/P(OC)(OC)=O)\[N+]#N>CCCCCC>[CH3:45][Si:43]([CH3:46])([CH3:44])[CH2:42][CH2:41][O:40][CH2:39][N:36]1[C:32]2[N:33]=[CH:34][N:35]=[C:30]([C:28]3[CH:27]=[N:26][N:25]([CH:19]([C:15]4[CH:14]=[C:13]([CH:18]=[CH:17][CH:16]=4)[C:11]#[N:12])[CH2:20][C:21]#[CH:2])[CH:29]=3)[C:31]=2[CH:38]=[CH:37]1
1
NC1=NC=2C=C(C=CC2C2=C1N=C(S2)CC)O.BrCC1=CC=C(C=C1)S(=O)(=O)NCCC1=CNC2=CC=CC=C12>>NC1=NC=2C=C(C=CC2C2=C1N=C(S2)CC)OCC2=CC=C(C=C2)S(=O)(=O)NCCC=2NC1=CC=CC=C1C2
5
[CH:1]1([CH2:4][N:5]2[C:10]3[N:11]=[CH:12][C:13](C(O)=O)=[CH:14][C:9]=3[C:8](=[O:18])[N:7]([CH2:19][CH:20]3[CH2:22][CH2:21]3)[C:6]2=[O:23])[CH2:3][CH2:2]1.C1C=CC(P([N:38]=[N+]=[N-])(C2C=CC=CC=2)=O)=CC=1>C(O)(C)(C)C>[NH2:38][C:13]1[CH:12]=[N:11][C:10]2[N:5]([CH2:4][CH:1]3[CH2:3][CH2:2]3)[C:6](=[O:23])[N:7]([CH2:19][CH:20]3[CH2:21][CH2:22]3)[C:8](=[O:18])[C:9]=2[CH:14]=1
2
COS(=O)(=O)OC.CC1=C(C=CC=C1I)N1N=NNC1=O>>CC1=C(C=CC=C1I)N1N=NN(C1=O)C
5
Br[C:2]1[C:3]([N:25]2[CH2:29][CH2:28][C@@H:27]([OH:30])[CH2:26]2)=[N:4][CH:5]=[C:6]([CH:24]=1)[C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17]([F:23])([F:22])[C:18]([F:21])([F:20])[F:19])=[CH:12][CH:11]=1)=[O:8].[F:31][C:32]1[CH:33]=[N:34][CH:35]=[C:36](B2OC(C)(C)C(C)(C)O2)[CH:37]=1>>[F:31][C:32]1[CH:37]=[C:36]([C:2]2[C:3]([N:25]3[CH2:29][CH2:28][C@@H:27]([OH:30])[CH2:26]3)=[N:4][CH:5]=[C:6]([C:7]([NH:9][C:10]3[CH:11]=[CH:12][C:13]([O:16][C:17]([F:23])([F:22])[C:18]([F:20])([F:21])[F:19])=[CH:14][CH:15]=3)=[O:8])[CH:24]=2)[CH:35]=[N:34][CH:33]=1
1
Cl.CN(C)CCCN=C=NCC.[Br:13][C:14]1[CH:22]=[C:18]([C:19]([OH:21])=O)[C:17]([OH:23])=[CH:16][CH:15]=1.[F:24][C:25]([F:39])([F:38])[C:26]1[CH:27]=[C:28]([CH:31]=[C:32]([C:34]([F:37])([F:36])[F:35])[CH:33]=1)[CH2:29][NH2:30].Cl>CN(C)C1C=CN=CC=1.O1CCCC1>[F:24][C:25]([F:38])([F:39])[C:26]1[CH:27]=[C:28]([CH2:29][NH:30][C:19](=[O:21])[C:18]2[CH:22]=[C:14]([Br:13])[CH:15]=[CH:16][C:17]=2[OH:23])[CH:31]=[C:32]([C:34]([F:35])([F:36])[F:37])[CH:33]=1
1
[CH2:1]([O:3][C:4]([CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[N:16]=[C:15]([CH3:20])[CH:14]=[C:13]2[OH:21])=[O:5])[CH3:2].[Br:22][CH2:23][CH2:24][CH2:25]Br.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:1]([O:3][C:4]([CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[N:16]=[C:15]([CH3:20])[CH:14]=[C:13]2[O:21][CH2:25][CH2:24][CH2:23][Br:22])=[O:5])[CH3:2]
1
IC1=C(CCl)C=CC=C1>>IC1=C(CP(OCC)(OCC)=O)C=CC=C1
5
C(C)(=O)NC1=CC(=NN1C1=C(C=C(C(=C1)SCC(F)(F)F)C)F)OC(C(OC(C(C(F)(F)F)(F)F)(F)F)F)(F)F>>C(C)(=O)NC1=CC(=NN1C1=C(C=C(C(=C1)S(=O)CC(F)(F)F)C)F)OC(C(OC(C(C(F)(F)F)(F)F)(F)F)F)(F)F
5
[C:1]1([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)[CH:6]=[CH:5][C:4](O)=[CH:3][CH:2]=1.[C:15]([O-:18])([O-])=O.[K+].[K+].[CH2:21](Br)[CH:22]=C>CC(C)=O>[CH2:15]([O:18][C:11]1([OH:14])[CH:12]=[CH:13][C:8]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[CH:9][CH2:10]1)[CH:21]=[CH2:22]
2
CC1(CC=C(CC1)C1=NC(=NC2=NC(=C(N=C12)C)C)N1C[C@@H](OCC1)C=1C=NN(C1)C)C>CCO[H].[HH].[Pd]>CC1(CCC(CC1)C1=NC(=NC=2NC(C(=NC12)C)C)N1C[C@@H](OCC1)C=1C=NN(C1)C)C
3
[C:1]([CH2:4][O:5][C:6]1[CH:11]=[C:10]([O:12][CH2:13][CH:14]=[C:15]([CH3:17])[CH3:16])[CH:9]=[CH:8][C:7]=1[C:18](=[O:20])[CH3:19])([OH:3])=[O:2].[CH2:21]([C:24]1[CH:31]=[CH:30][C:27]([CH:28]=O)=[CH:26][CH:25]=1)[CH:22]=[CH2:23].[OH-].[K+]>C(O)C>[C:1]([CH2:4][O:5][C:6]1[CH:11]=[C:10]([O:12][CH2:13][CH:14]=[C:15]([CH3:16])[CH3:17])[CH:9]=[CH:8][C:7]=1[C:18](=[O:20])[CH:19]=[CH:28][C:27]1[CH:30]=[CH:31][C:24]([CH2:21][CH:22]=[CH2:23])=[CH:25][CH:26]=1)([OH:3])=[O:2]
1
[Cl:1][C:2]1[C:7]([N:8]([CH3:10])[CH3:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:11][OH:12].C(N(CC)CC)C.[CH3:20][S:21](Cl)(=[O:23])=[O:22].CN(C1C=CC=CN=1)C>ClCCl>[Cl:1][C:2]1[C:7]([N:8]([CH3:9])[CH3:10])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:11][O:12][S:21]([CH3:20])(=[O:23])=[O:22]
1
C(C)(C)(C)OC(=O)N[C@@H](C(=O)O)C.Cl.COC=1C=C(C=CC1OC)C1=NN(C([C@@H]2CCCC[C@H]12)=O)C1CCNCC1>>COC=1C=C(C=CC1OC)C1=NN(C([C@@H]2CCCC[C@H]12)=O)C1CCN(CC1)C([C@@H](C)NC(OC(C)(C)C)=O)=O
5
ClC1=CC2=C(OC(C(N2C2CCN(CC2)C(=O)OC(C)(C)C)=O)(C)C)N=C1>ClCCl.C(=O)(C(F)(F)F)O>FC(C(=O)O)(F)F.ClC1=CC2=C(OC(C(N2C2CCNCC2)=O)(C)C)N=C1
3