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= = Prognosis = =
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Acute myeloid leukemia is a curable disease ; the chance of cure for a specific person depends on a number of prognostic factors .
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= = = Cytogenetics = = =
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The single most important prognostic factor in AML is cytogenetics , or the chromosomal structure of the leukemic cell . Certain cytogenetic abnormalities are associated with very good outcomes ( for example , the ( 15 ; 17 ) translocation in acute promyelocytic leukemia ) . About half of people with AML have " normal... |
The first publication to address cytogenetics and prognosis was the MRC trial of 1998 :
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Later , the Southwest Oncology Group and Eastern Cooperative Oncology Group and , later still , Cancer and Leukemia Group B published other , mostly overlapping lists of cytogenetics prognostication in leukemia .
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= = = Myelodysplastic syndrome = = =
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AML which arises from a pre @-@ existing myelodysplastic syndrome ( MDS ) or myeloproliferative disease ( so @-@ called secondary AML ) has a worse prognosis , as does treatment @-@ related AML arising after chemotherapy for another previous malignancy . Both of these entities are associated with a high rate of unfavo... |
= = = Other prognostic markers = = =
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In some studies , age > 60 years and elevated lactate dehydrogenase level were also associated with poorer outcomes . As with most forms of cancer , performance status ( i.e. the general physical condition and activity level of the person ) plays a major role in prognosis as well .
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= = = = Genotype = = = =
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A large number of molecular alterations are under study for their prognostic impact in AML . However , only FLT3 @-@ ITD , NPM1 , CEBPA and c @-@ KIT are currently included in validated international risk stratification schema . These are expected to increase rapidly in the near future . FLT3 internal tandem duplicati... |
Researchers are investigating the clinical significance of c @-@ KIT mutations in AML . These are prevalent , and potentially clinically relevant because of the availability of tyrosine kinase inhibitors , such as imatinib and sunitinib that can block the activity of c @-@ KIT pharmacologically . It is expected that a... |
= = = Expectation of cure = = =
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Cure rates in clinical trials have ranged from 20 β 45 % ; although clinical trials often include only younger people and those able to tolerate aggressive therapies . The overall cure rate for all people with AML ( including the elderly and those unable to tolerate aggressive therapy ) is likely lower . Cure rates fo... |
= = Epidemiology = =
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Acute myeloid leukemia is a relatively rare cancer . There are approximately 10 @,@ 500 new cases each year in the United States , and the incidence rate has remained stable from 1995 through 2005 . AML accounts for 1 @.@ 2 % of all cancer deaths in the United States .
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The incidence of AML increases with age ; the median age at diagnosis is 63 years . AML accounts for about 90 % of all acute leukemias in adults , but is rare in children . The rate of therapy @-@ related AML ( that is , AML caused by previous chemotherapy ) is rising ; therapy @-@ related disease currently accounts f... |
There is some geographic variation in the incidence of AML . In adults , the highest rates are seen in North America , Europe , and Oceania , while adult AML is rarer in Asia and Latin America . In contrast , childhood AML is less common in North America and India than in other parts of Asia . These differences may be... |
= = = UK = = =
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AML accounts for 34 % of all leukaemia cases in the UK , and around 2 @,@ 900 people were diagnosed with the disease in 2011 .
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= = History = =
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The first published description of a case of leukemia in medical literature dates to 1827 , when French physician Alfred @-@ Armand @-@ Louis @-@ Marie Velpeau described a 63 @-@ year @-@ old florist who developed an illness characterized by fever , weakness , urinary stones , and substantial enlargement of the liver ... |
The term " leukemia " was coined by Rudolf Virchow , the renowned German pathologist , in 1856 . As a pioneer in the use of the light microscope in pathology , Virchow was the first to describe the abnormal excess of white blood cells in people with the clinical syndrome described by Velpeau and Bennett . As Virchow w... |
Further advances in the understanding of acute myeloid leukemia occurred rapidly with the development of new technology . In 1877 , Paul Ehrlich developed a technique of staining blood films which allowed him to describe in detail normal and abnormal white blood cells . Wilhelm Ebstein introduced the term " acute leuk... |
In 2008 , AML became the first cancer genome to be fully sequenced . DNA extracted from leukemic cells were compared to unaffected skin . The leukemic cells contained acquired mutations in several genes that had not previously been associated with the disease .
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= = Pregnancy = =
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Leukemia is rarely associated with pregnancy , affecting only about 1 in 10 @,@ 000 pregnant women . How it is handled depends primarily on the type of leukemia . Acute leukemias normally require prompt , aggressive treatment , despite significant risks of pregnancy loss and birth defects , especially if chemotherapy ... |
= Love Me Like You =
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" Love Me Like You " is a song recorded by British girl group Little Mix for their third studio album , Get Weird ( 2015 ) . The song was released on 25 September 2015 , as the second single from the album . Produced by Steve Mac , he co @-@ wrote the song with Iain James , Camille Purcell and James Newman . Backed by... |
Critical response to " Love Me Like You " was positive : critics praised its vintage style and highlighted it as an album standout . It reached number 11 on the UK Singles Chart and has been certified gold by the BPI . The accompanying music video for the song was set at a high school dance . Unbeknownst to each membe... |
= = Background and release = =
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" Love Me Like You " was written by Steve Mac , Camille Purcell , Iain James and James Newman for Little Mix 's third studio album , Get Weird ( 2015 ) . It was published by Rokstone Music Ltd. under exclusive licence to BMG Rights Management ( UK ) Ltd ; Kobalt Music Group ; Sony / ATV Music Publishing ; Black Butter... |
The group announced on 9 September 2015 that " Love Me Like You " would be the second single to be released from the album , and that it would be made available to pre @-@ order on 11 September , and be released on 25 September . It was released by Syco and Columbia in Ireland and the United Kingdom on 25 September 20... |
= = Composition = =
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" Love Me Like You " has been described as a down @-@ tempo " ode to ' 60s doo @-@ wop " retro style pop song , which lasts for a duration of three minutes , seventeen seconds . The song is composed in the key of G major using common time and a tempo of 106 beats per minute . Instrumentation is provided by " vintage "... |
The song opens with the group harmonising " Sha la la la " over pianos . The lyrics are about puppy love , as they yearningly sing " Last night I lay in bed so blue / Cause ' I realized the truth / They can 't love me like you / I tried to find somebody new / Baby they ain 't got a clue / Can 't love me like you . " F... |
= = Critical reception = =
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Andy Gill of The Independent described the track as having a " nice " retro sound , and singled it out as being one of his top three songs from the album to download , along with " Black Magic " and " Grown " . Writing for NME , Nick Levine thought that " Love Me Like You " was reminiscent of songs recorded by Stooshe... |
= = Chart performance = =
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In the United Kingdom , " Love Me Like You " debuted at number 21 on the UK Singles Chart on 8 October 2015 . It later peaked at number 11 on 7 January 2016 . It also peaked at number nine on the UK Singles Downloads Chart . The track has been certified gold by the British Phonographic Industry ( BPI ) , denoting ship... |
= = Music video = =
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The accompanying music video for " Love Me Like You " was released on 10 October 2015 . The video takes place at a school dance , where a professor in the hall ( the same man who appeared in their previous single 's video " Black Magic " ) tells everyone that it is the last dance . Jade , Leigh @-@ Anne , Jesy and Per... |
Finally , he invited Perrie to be his date after she fell off her bike while staring at him work out on a field and pouring water over his torso to cool down . He helps her up , and gives her a corsage . Toward the end of the video , they sit on a bench next to the entrance , and see their date walk in with another gi... |
= = Live performances = =
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" Little Mix " performed " Love Me Like You " live on the seventh season of The X Factor in Australia on 13 October 2015 . Capital praised their performed , writing that it set an " amazing example " for the contestants on the show and that their vocals were " pitch perfect " . On 1 November , the group performed a " ... |
= = Track listing = =
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Digital download
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" Love Me Like You " β 3 : 17
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Digital download β The Collection
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" Love Me Like You " ( Christmas Mix ) β 3 : 29
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" Lightning " β 5 : 09
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" Love Me Like You " ( J @-@ Vibe Reggae Remix ) β 3 : 04
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" Love Me Like You " ( Bimbo Jones Remix ) β 3 : 07
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" Love Me Like You " ( 7th Heaven Remix ) β 3 : 10
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" Love Me Like You " ( Exclusive Interview ) β 3 : 16
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" Love Me Like You " ( Instrumental ) β 3 : 15
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= = Charts and certifications = =
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= Shaoguan incident =
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