text stringlengths 22 455 | relations listlengths 1 24 |
|---|---|
A 58-year old patient is reported who developed an ischaemic cerebrovascular accident 22 hours after successful thrombolysis with streptokinase for life-threatening pulmonary emboli. | [
{
"ade": "ischaemic cerebrovascular accident",
"drug": "streptokinase"
}
] |
We report the cases of two patients who developed acute hepatitis after taking riluzole at the recommended dose (100 mg daily) for 7 and 4 weeks, respectively. | [
{
"ade": "hepatitis",
"drug": "riluzole"
}
] |
In eight patients, a mean decrease in serum Na+ of 8.25 +/- 3.2 mEq/L was observed after a single 200 mg intravenous dose of lorcainide. | [
{
"ade": "decrease in serum Na+",
"drug": "lorcainide"
}
] |
A depressed woman with no history of bipolar illness developed a manic episode during treatment with fluoxetine. | [
{
"ade": "manic episode",
"drug": "fluoxetine"
}
] |
Three patients received respectively 190 mg, 175 mg, and 196 mg of methotrexate and developed bilateral pulmonary infiltrates without evidence of peripheral blood eosinophilia. | [
{
"ade": "bilateral pulmonary infiltrates",
"drug": "methotrexate"
}
] |
We describe a 5-year-old girl showed recovery of vincristine induced cranial polyneuropathy with pyridoxine and pyridostigmine treatment. | [
{
"ade": "cranial polyneuropathy",
"drug": "vincristine"
}
] |
RESULTS: Five of 70 patients who had begun leflunomide therapy had significant weight loss that could not be linked to other identifiable etiologies. | [
{
"ade": "weight loss",
"drug": "leflunomide"
}
] |
Argatroban for heparin-induced thrombocytopenia in hepato-renal failure and CVVHD. | [
{
"ade": "thrombocytopenia",
"drug": "heparin"
}
] |
Renal injury due to anastrozole has not been published in the English literature. | [
{
"ade": "Renal injury",
"drug": "anastrozole"
}
] |
Pulmonary toxicity with mefloquine. | [
{
"ade": "Pulmonary toxicity",
"drug": "mefloquine"
}
] |
A patient, while on intravenous ritodrine therapy for preterm labor, experienced an episode of acute chest pain. | [
{
"ade": "acute chest pain",
"drug": "ritodrine"
}
] |
Recurrent hyponatremia associated with citalopram and mirtazapine. | [
{
"ade": "Recurrent hyponatremia",
"drug": "mirtazapine"
},
{
"ade": "Recurrent hyponatremia",
"drug": "citalopram"
}
] |
This report describes an unexpected drug-induced hepatitis in a previously healthy young woman exposed to 2 doses of amodiaquine and artesunate. | [
{
"ade": "hepatitis",
"drug": "artesunate"
},
{
"ade": "hepatitis",
"drug": "amodiaquine"
}
] |
This report presents a case of acute lung injury developing within hours after administration of mefloquine for a low-level Plasmodium falciparum malaria, which was persistent despite halofantrine therapy. | [
{
"ade": "acute lung injury",
"drug": "mefloquine"
}
] |
CONCLUSION: This case illustrates a potential link between dermatologic and ocular 5-FU toxicities. | [
{
"ade": "dermatologic and ocular 5-FU toxicities",
"drug": "5-FU"
}
] |
In four patients, spasm occurred spontaneous and in one patient after 0.05 mg of ergonovine. | [
{
"ade": "spasm",
"drug": "ergonovine"
}
] |
A second patient with a similar glucose tolerance test result showed postprandial hyperglycemia when treated similarly with betamethasone valerate cream 0.1%. | [
{
"ade": "postprandial hyperglycemia",
"drug": "betamethasone valerate"
}
] |
One of these was clofazimine, an aniline aposafranine derivative known to produce a ceroid-like pigment in the tissues of patients treated with this drug or lepromatous leprosy. | [
{
"ade": "ceroid-like pigment",
"drug": "clofazimine"
}
] |
CONCLUSIONS: Hypersensitivity reactions to cyclosporine are due to Cremophor EL. | [
{
"ade": "Hypersensitivity reactions",
"drug": "cyclosporine"
},
{
"ade": "Hypersensitivity reactions",
"drug": "Cremophor EL"
}
] |
A generalized tonic-clonic seizure occurred a few minutes after injection of the morphine antagonist naloxone. | [
{
"ade": "generalized tonic-clonic seizure",
"drug": "naloxone"
}
] |
The majority of radiation recall reactions attributed to gemcitabine are reported to affect internal tissue or organs. | [
{
"ade": "radiation recall reactions",
"drug": "gemcitabine"
}
] |
Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy are described in a 61-year-old diabetic patient who presented wit hypoglycaemic coma. | [
{
"ade": "Intrahepatic cholestasis",
"drug": "glibenclamide"
},
{
"ade": "cutaneous bullae",
"drug": "glibenclamide"
}
] |
This concerns 2 male patients who experienced incontinence while taking venlafaxine. | [
{
"ade": "incontinence",
"drug": "venlafaxine"
}
] |
Total blindness with a transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials developed in a 54-year-old man after the use of quinine sulfate for leg cramps. | [
{
"ade": "Total blindness with a transient tonic pupillary response",
"drug": "quinine sulfate"
},
{
"ade": "denervation supersensitivity",
"drug": "quinine sulfate"
},
{
"ade": "abnormal visual-evoked potentials",
"drug": "quinine sulfate"
}
] |
Pigmentary disorders are recognized adverse effects of the semi-synthetic tetracycline derivative antibiotic, minocycline. | [
{
"ade": "Pigmentary disorders",
"drug": "minocycline"
}
] |
Ticlopidine-induced marrow aplasia treated with cyclosporine. | [
{
"ade": "marrow aplasia",
"drug": "Ticlopidine"
}
] |
Postoperative hypocalcemic tetany caused by fleet phospho-soda preparation in a patient taking alendronate sodium: report of a case. | [
{
"ade": "hypocalcemic tetany",
"drug": "fleet phospho-soda"
},
{
"ade": "hypocalcemic tetany",
"drug": "alendronate sodium"
}
] |
Cryptococcus neoformans fatal sepsis in a chronic lymphocytic leukemia patient treated with alemtuzumab: case report and review of the literature. | [
{
"ade": "Cryptococcus neoformans fatal sepsis",
"drug": "alemtuzumab"
}
] |
Cough induced by quinapril with resolution after changing to fosinopril. | [
{
"ade": "Cough",
"drug": "quinapril"
}
] |
Neurophysiological mechanisms which aid in elucidating the role of disulfiram in the etiology of catatonia are discussed. | [
{
"ade": "catatonia",
"drug": "disulfiram"
}
] |
Fracture of the femoral neck occurred in one patient during PSL therapy, although the relationship between the fracture and PSL therapy was uncertain. | [
{
"ade": "Fracture of the femoral neck",
"drug": "PSL"
}
] |
Visual loss after a single small dose of vincristine has never been reported. | [
{
"ade": "Visual loss",
"drug": "vincristine"
}
] |
Massive CBZ OD may produce a reversible encephalopathy that includes cortical hyperexcitability, a profound burst-suppression EEG pattern, and cranial nerve areflexia. | [
{
"ade": "cranial nerve areflexia",
"drug": "CBZ"
},
{
"ade": "cortical hyperexcitability",
"drug": "CBZ"
},
{
"ade": "profound burst-suppression EEG pattern",
"drug": "CBZ"
},
{
"ade": "reversible encephalopathy",
"drug": "CBZ"
}
] |
When measured, the serum lithium level had increased 4-fold during acyclovir therapy. | [
{
"ade": "serum lithium level had increased",
"drug": "acyclovir"
},
{
"ade": "serum lithium level had increased",
"drug": "lithium"
}
] |
Ezetimibe-induced acute pancreatitis. | [
{
"ade": "acute pancreatitis",
"drug": "Ezetimibe"
}
] |
The ulcer did not respond to antibiotic treatment and healed shortly after withholding ATRA. | [
{
"ade": "ulcer",
"drug": "ATRA"
}
] |
Multiple pulmonary nodules: an unusual presentation of fludarabine pulmonary toxicity: case report and review of literature. | [
{
"ade": "pulmonary toxicity",
"drug": "fludarabine"
},
{
"ade": "Multiple pulmonary nodules",
"drug": "fludarabine"
}
] |
Fulminant hepatic failure associated with bicalutamide. | [
{
"ade": "Fulminant hepatic failure",
"drug": "bicalutamide"
}
] |
These in vitro findings and clinical course suggest that TRAb/TBII without thyroid-stimulating activity may develop in patients with amiodarone-induced destructive thyroiditis, as reported in patients with destructive thyroiditis, such as subacute and silent thyroiditis. | [
{
"ade": "TRAb/TBII without thyroid-stimulating activity",
"drug": "amiodarone"
},
{
"ade": "thyroiditis",
"drug": "amiodarone"
},
{
"ade": "destructive thyroiditis",
"drug": "amiodarone"
}
] |
The newborn manifested a four day course of lethargy with unexplained high lithium levels in the adult toxic range. | [
{
"ade": "lethargy",
"drug": "lithium"
}
] |
Spindle coma in benzodiazepine toxicity: case report. | [
{
"ade": "Spindle coma",
"drug": "benzodiazepine"
}
] |
Sudden cardiac death due to hypersensitivity myocarditis during clozapine treatment. | [
{
"ade": "Sudden cardiac death",
"drug": "clozapine"
},
{
"ade": "hypersensitivity myocarditis",
"drug": "clozapine"
}
] |
PATIENT AND METHOD: A 34-year-old woman with chronic hepatitis C, genotype 3, receiving pegylated interferon alpha-2a and ribavirin for 6 months, developed progressive malaise and anemia 6 months after the end of treatment. | [
{
"ade": "anemia",
"drug": "ribavirin"
},
{
"ade": "anemia",
"drug": "pegylated interferon alpha-2a"
},
{
"ade": "progressive malaise",
"drug": "pegylated interferon alpha-2a"
},
{
"ade": "progressive malaise",
"drug": "ribavirin"
}
] |
Multiple myeloma complicated by congestive heart failure following first administration of recombinant alpha-interferon. | [
{
"ade": "congestive heart failure",
"drug": "recombinant alpha-interferon"
}
] |
However, a large case-control study included three cases of either Stevens-Johnson syndrome or toxic epidermal necrolysis associated with ofloxacin use, but no details of the cases were given. | [
{
"ade": "toxic epidermal necrolysis",
"drug": "ofloxacin"
},
{
"ade": "Stevens-Johnson syndrome",
"drug": "ofloxacin"
}
] |
Foscarnet-induced severe hypomagnesemia and other electrolyte disorders. | [
{
"ade": "electrolyte disorders",
"drug": "Foscarnet"
},
{
"ade": "severe hypomagnesemia",
"drug": "Foscarnet"
}
] |
Intravenous valproate associated with significant hypotension in the treatment of status epilepticus. | [
{
"ade": "hypotension",
"drug": "valproate"
}
] |
To our knowledge, this is the first case of spontaneous remission of MTX-associated gastric LPD after discontinuation of MTX therapy. | [
{
"ade": "gastric LPD",
"drug": "MTX"
}
] |
Ofloxacin: a probable cause of toxic epidermal necrolysis. | [
{
"ade": "toxic epidermal necrolysis",
"drug": "Ofloxacin"
}
] |
Trimethoprim-sulfamethoxazole-induced aseptic meningitis. | [
{
"ade": "aseptic meningitis",
"drug": "Trimethoprim-sulfamethoxazole"
}
] |
Hepatotoxicity induced by cyproterone acetate: a report of three cases. | [
{
"ade": "Hepatotoxicity",
"drug": "cyproterone acetate"
}
] |
Prolongation of the QT interval observed in a Japanese patient with vivax malaria following treatment with halofantrine. | [
{
"ade": "Prolongation of the QT interval",
"drug": "halofantrine"
}
] |
We report a case of radiotherapy-enhanced aminoglutethimide skin toxicity in a patient with metastatic breast cancer. | [
{
"ade": "skin toxicity",
"drug": "aminoglutethimide"
}
] |
Acute myocardial ischemia following accidental intravenous administration of epinephrine in high concentration. | [
{
"ade": "Acute myocardial ischemia",
"drug": "epinephrine"
}
] |
After nine previous uncomplicated cycles she developed severe anaphylaxis to cisplatin. | [
{
"ade": "anaphylaxis",
"drug": "cisplatin"
}
] |
A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium. | [
{
"ade": "generalized rigidity",
"drug": "olanzapine"
},
{
"ade": "leukocytosis",
"drug": "olanzapine"
},
{
"ade": "fever",
"drug": "olanzapine"
},
{
"ade": "fever",
"drug": "lithium"
},
{
"ade": "leukocytosis",
"drug": "lithium"
},
{
"ade": "increased... |
A case of phenobarbital exacerbation of a preexisting maladaptive behavior partially suppressed by chlorpromazine and misinterpreted as chlorpromazine efficacy. | [
{
"ade": "exacerbation of a preexisting maladaptive behavior",
"drug": "phenobarbital"
}
] |
Cardiac arrest after esmolol administration: a review of acute beta-blocker toxicity. | [
{
"ade": "Cardiac arrest",
"drug": "esmolol"
}
] |
Interference with the cortisol axis by the microtubule antagonist, CPH82. | [
{
"ade": "Interference with the cortisol axis",
"drug": "CPH82"
}
] |
A patient is described who developed a poorly differentiated sarcoma after cyclophosphamide was used to treat his rheumatoid arthritis. | [
{
"ade": "sarcoma",
"drug": "cyclophosphamide"
}
] |
Seventy-four per cent of patients with epileptogenic disorders seen at the Emergency Unit at Groote Schuur Hospital were on phenytoin and 11.6% of these had blood levels in the toxic range. | [
{
"ade": "blood levels in the toxic range",
"drug": "phenytoin"
}
] |
CONCLUSIONS: Peripheral administration of low-dose vasopressin for septic shock should be discouraged because of the risk of ischemic skin complications. | [
{
"ade": "ischemic skin complications",
"drug": "vasopressin"
}
] |
Transient global amnesia after clioquinol: five personal observations from outside Japan. | [
{
"ade": "Transient global amnesia",
"drug": "clioquinol"
}
] |
Withdrawal of Depakote resulted in resolution of the effusion. | [
{
"ade": "effusion",
"drug": "Depakote"
}
] |
Thoracoscopic biopsy to confirm metastasis revealed instead fibrotic lesions apparently attributable to bleomycin or cyclophosphamide. | [
{
"ade": "fibrotic lesions",
"drug": "cyclophosphamide"
},
{
"ade": "fibrotic lesions",
"drug": "bleomycin"
}
] |
We report the first case of acute renal failure with hyperkalemia associated with the recently marketed direct renin inhibitor aliskiren. | [
{
"ade": "hyperkalemia",
"drug": "aliskiren"
},
{
"ade": "acute renal failure",
"drug": "aliskiren"
}
] |
We describe two ELBW infants affected by hyperkalaemia, treated with Kayexalate, who developed serious hypernatraemia, that has never been reported before in preterm infants. | [
{
"ade": "hypernatraemia",
"drug": "Kayexalate"
}
] |
The mechanism of RTA induced by FK506 has not yet been clearly elucidated. | [
{
"ade": "RTA",
"drug": "FK506"
}
] |
We describe 2 cases of SJS related to nevirapine use and review the literature on this newly recognized association. | [
{
"ade": "SJS",
"drug": "nevirapine"
}
] |
Osteonecrosis is a serious side effect of antiemetic treatment with dexamethasone and this serious complication should be incorporated in the current guidelines. | [
{
"ade": "Osteonecrosis",
"drug": "dexamethasone"
}
] |
Adenosine-induced ventricular fibrillation. | [
{
"ade": "ventricular fibrillation",
"drug": "Adenosine"
}
] |
The cause of his bleeding was a severe thrombocytopoaenia, induced by chronic ingestion of quinine. | [
{
"ade": "severe thrombocytopoaenia",
"drug": "quinine"
}
] |
Horner's syndrome and demyelinating peripheral neuropathy caused by high-dose cytosine arabinoside. | [
{
"ade": "demyelinating peripheral neuropathy",
"drug": "cytosine arabinoside"
},
{
"ade": "Horner's syndrome",
"drug": "cytosine arabinoside"
}
] |
Carbamazepine-induced hyperammonemia. | [
{
"ade": "hyperammonemia",
"drug": "Carbamazepine"
}
] |
Corneal endothelial deposits associated with rifabutin use. | [
{
"ade": "Corneal endothelial deposits",
"drug": "rifabutin"
}
] |
CONCLUSIONS: There is very little published information regarding ofloxacin-induced toxic epidermal necrolysis. | [
{
"ade": "toxic epidermal necrolysis",
"drug": "ofloxacin"
}
] |
We report three cases of severe hepatotoxicity related to benzarone, a benzofuran derivative. | [
{
"ade": "severe hepatotoxicity",
"drug": "benzarone"
}
] |
The results clearly demonstrate that CPH82 was associated with suppression of the endogeneous production of ACTH and cortisol with a concomitant paradoxical picture of clinical hypercortisolism. | [
{
"ade": "hypercortisolism",
"drug": "CPH82"
},
{
"ade": "suppression of the endogeneous production of ACTH and cortisol",
"drug": "CPH82"
}
] |
Severe acidosis from acetazolamide in a diabetic patient. | [
{
"ade": "Severe acidosis",
"drug": "acetazolamide"
}
] |
Rupture of a cerebral aneurysm associated with nifedipine treatment. | [
{
"ade": "Rupture of a cerebral aneurysm",
"drug": "nifedipine"
}
] |
CONCLUSION: The findings in these two patients suggest that colchicine may delay corneal wound healing. | [
{
"ade": "delay corneal wound healing",
"drug": "colchicine"
}
] |
We describe a 74-year-old man with rheumatoid arthritis (RA) who developed syndrome of inappropriate secretion of antidiuretic hormone (SIADH) 1.5 months after commencement of mizoribin prescription when his arthritis was improved. | [
{
"ade": "syndrome of inappropriate secretion of antidiuretic hormone",
"drug": "mizoribin"
},
{
"ade": "SIADH",
"drug": "mizoribin"
}
] |
Theoretical basal ganglia toxicologic mechanisms of methanol poisoning are reviewed, and the role of brain imaging studies will regard to diagnosis, prognosis and impact on management is discussed. | [
{
"ade": "methanol poisoning",
"drug": "methanol"
}
] |
We present a case report of a patient who developed a prolonged QT while being treated with oral methadone for a chronic pain syndrome. | [
{
"ade": "prolonged QT",
"drug": "methadone"
}
] |
We describe 2 children with cerebral palsy who suffered significant morbidity immediately after treatment with hyperbaric oxygen. | [
{
"ade": "morbidity",
"drug": "hyperbaric oxygen"
}
] |
We report on three observations of parkinsonian patients with levo-dopa-induced diphasic dyskinesias, who received subcutaneous apomorphine to reduce the duration of abnormal movements. | [
{
"ade": "diphasic dyskinesias",
"drug": "levo-dopa"
}
] |
BACKGROUND: Gemcitabine has mild renal toxicity, but cases of gemcitabine-associated hemolytic-uremic syndrome (HUS) have been reported. | [
{
"ade": "hemolytic-uremic syndrome",
"drug": "gemcitabine"
},
{
"ade": "HUS",
"drug": "Gemcitabine"
},
{
"ade": "HUS",
"drug": "gemcitabine"
},
{
"ade": "renal toxicity",
"drug": "Gemcitabine"
},
{
"ade": "hemolytic-uremic syndrome",
"drug": "Gemcitabine"
}... |
A 59-year-old woman with myasthenia gravis who received a large dose of pyridostigmine bromide developed postoperative psychosis and was diagnosed as having bromide intoxication. | [
{
"ade": "bromide intoxication",
"drug": "pyridostigmine bromide"
},
{
"ade": "postoperative psychosis",
"drug": "pyridostigmine bromide"
}
] |
Capecitabine-induced headache responding to diltiazem. | [
{
"ade": "headache",
"drug": "Capecitabine"
}
] |
Acute non-lymphocytic leukemia in patients with ovarian carcinoma following long-term treatment with Treosulfan (= dihydroxybusulfan). | [
{
"ade": "Acute non-lymphocytic leukemia",
"drug": "Treosulfan"
},
{
"ade": "Acute non-lymphocytic leukemia",
"drug": "dihydroxybusulfan"
}
] |
Based on the Naranjo probability scale, serotonin syndrome was a probable adverse reaction associated with co-administration of citalopram and fentanyl. | [
{
"ade": "serotonin syndrome",
"drug": "citalopram"
},
{
"ade": "serotonin syndrome",
"drug": "fentanyl"
}
] |
The incidence of oral-verapamil-induced hypotension in the presence of concomitant beta-adrenergic blockade by the oral route is quite rare. | [
{
"ade": "hypotension",
"drug": "verapamil"
}
] |
Acute acoustic nerve palsy associated with vincristine therapy. | [
{
"ade": "Acute acoustic nerve palsy",
"drug": "vincristine"
}
] |
Disopyramide (Norpace)-induced hypoglycemia. | [
{
"ade": "hypoglycemia",
"drug": "Disopyramide"
},
{
"ade": "hypoglycemia",
"drug": "Norpace"
}
] |
We report 5 patients (3 patients with chronic hepatitis C treated with pegylated interferon alfa-2b in association with oral ribavirin and two patients with chronic myelocytic leukemia) who developed local cutaneous reactions at sites of injection after the administration of weekly subcutaneous injections of pegylated ... | [
{
"ade": "local cutaneous reactions",
"drug": "pegylated interferon alfa-2b"
},
{
"ade": "local cutaneous reactions",
"drug": "ribavirin"
}
] |
Capecitabine-induced multifocal leukoencephalopathy: a report of five cases. | [
{
"ade": "multifocal leukoencephalopathy",
"drug": "Capecitabine"
}
] |
This report highlights a case of drug-induced dysphagia in a patient receiving haloperidol for obsessive nocturnal thoughts and auditory disturbances. | [
{
"ade": "dysphagia",
"drug": "haloperidol"
}
] |
The currently available clinical and neuropharmacologic data suggest that carbamazepine may be an antagonist of dopamine and that this property is responsible for the production of dystonia. | [
{
"ade": "dystonia",
"drug": "carbamazepine"
}
] |
One patient had severe temporary weakness after an ampicillin sodium challenge. | [
{
"ade": "severe temporary weakness",
"drug": "ampicillin sodium"
}
] |
Effect of beta-blockade on symptomatic dexamethasone-induced hypertrophic obstructive cardiomyopathy in premature infants: three case reports and literature review. | [
{
"ade": "hypertrophic obstructive cardiomyopathy",
"drug": "dexamethasone"
}
] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.