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10.15252/msb.20209833 | Single-cell transcriptomics reveals immune response of intestinal cell types to viral infection | 2021 | Figure 1 | <p><strong>Figure 1. Interferons protect human intestinal organoids from HAstV1 infection.</strong></p><p><strong>A</strong>. Cryo-sections of human organoids were analyzed for the presence of enterocytes (E-cad), Goblet cells (Muc-2) and tight junctions (ZO-1) by indirect immunofluorescence. Nuclei are stained with DA... | https://api.sourcedata.io/file.php?figure_id=41858 | [
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10.15252/msb.20209833 | Single-cell transcriptomics reveals immune response of intestinal cell types to viral infection | 2021 | Figure 3 | <p><strong>Figure 3. Single-cell profiling and multiplex <em>in situ</em> RNA hybridization of human ileum-derived organoids.</strong></p><p><strong>A</strong>. UMAP of scRNA-Seq data from human ileum-derived organoids (n=16,682 cells); dots corresponding to cells are colored by the cell type.</p><p><strong>B</strong>.... | https://api.sourcedata.io/file.php?figure_id=41862 | [
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10.15252/msb.20209833 | Single-cell transcriptomics reveals immune response of intestinal cell types to viral infection | 2021 | Figure 5 | <p><strong>Figure 5. Multiplex <em>in situ</em> RNA FISH visualizes immune signature in HastV1-infected and bystander cells.</strong></p><p><strong>A.</strong> One image per condition was used to show the multiplex in situ RNA FISH. A representative region of the images was chosen and cropped in order to have a zoom-in... | https://api.sourcedata.io/file.php?figure_id=41866 | [
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10.15252/embj.2021109783 | Spt5 histone binding activity preserves chromatin during transcription by RNA polymerase II | 2022 | Figure 1 | <p><strong>Figure 1</strong></p><p>Eukaryotic Spt5N binds histones H3-H4 via an evolutionarily conserved motif. (<strong>A</strong>) Domain structure of Spt5 / NusG proteins. The enlarged inset shows a conserved region of Spt5N from <em>Saccharomyces cerevisiae</em> (S.c.), <em>Schizosaccharomyces pombe</em> (S.p.), <e... | https://api.sourcedata.io/file.php?figure_id=45929 | [
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10.15252/embj.2021109783 | Spt5 histone binding activity preserves chromatin during transcription by RNA polymerase II | 2022 | Figure 2 | <p><strong>Figure 2</strong></p><p>Mutation of the histone-binding motif of Spt5N is lethal, even in the presence of wild type Spt5. (<strong>A</strong>) Linearised versions of the indicated plasmids were transformed into <em>SPT5-9MYC</em> budding yeast cells and integrated at the <em>ura3</em> locus. For each transfo... | https://api.sourcedata.io/file.php?figure_id=45931 | [
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10.15252/embj.2021109783 | Spt5 histone binding activity preserves chromatin during transcription by RNA polymerase II | 2022 | Figure 3 | <p><strong>Figure 3</strong></p><p>The histone-binding activity of Spt5N is dispensable for progression of the Pol II elongation complex through transcription units. (<strong>A</strong>) Experimental procedure, based on the yeast strains YCE281, YCE350 and YCE356. (<strong>B</strong>) Immunoblot analysis at the indicat... | https://api.sourcedata.io/file.php?figure_id=45933 | [
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10.15252/embj.2021109783 | Spt5 histone binding activity preserves chromatin during transcription by RNA polymerase II | 2022 | Figure 4 | <sd-panel><p><strong>Figure 4</strong></p> <p>Spt5N histone binding activity preserves nucleosome integrity during transcription. (<strong>A</strong>) Samples from the experiment described in Figure 3A were also processed for MNase-Seq. For each of the three indicated strains, the histograms represent the normalized DN... | https://api.sourcedata.io/file.php?figure_id=45935 | [
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26666269 | 10.15252/emmm.201505505 | Endothelial cell-derived Angiopoietin-2 is a therapeutic target in treatment-naive and Bevacizumab-resistant glioblastoma | 2015 | Figure 1 | <p>Figure 1: Endothelial Ang-2 upregulation correlates with WHO grading in human gliomas. ELISA displaying human Ang-2 (A) and Ang-1 (B) level in serum of healthy patients (Ang-2 n=4; Ang-1 n=21) or patients with low grade glioma (WHOII) (n=5), anaplastic astrocytoma (WHOIII) (n=7) or glioblastoma (WHOIV) (n=39) are sh... | https://api.sourcedata.io/file.php?figure_id=5251 | [
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26666269 | 10.15252/emmm.201505505 | Endothelial cell-derived Angiopoietin-2 is a therapeutic target in treatment-naive and Bevacizumab-resistant glioblastoma | 2015 | Figure 2 | <p>Figure 2: Endothelial Ang-2 expression reduced pericyte coverage and increased macrophage infiltration in experimental glioblastoma. GL261 cells were intracerebrally transplanted in wild type or Ang-2 gain-of-function mice (Ang-2 DT). Brain tumor sections were stained with antibodies against CD31 and desmin (A), and... | https://api.sourcedata.io/file.php?figure_id=5252 | [
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26666269 | 10.15252/emmm.201505505 | Endothelial cell-derived Angiopoietin-2 is a therapeutic target in treatment-naive and Bevacizumab-resistant glioblastoma | 2015 | Figure 3 | <p>Figure 3: Infiltrating leukocyte subsets in human glioma. Paraffin sections of healthy human brain (n=3), low grade glioma (n=12), anaplastic astrocytoma (n=7) and glioblastoma (n=9) were stained for IBA1 (macrophages/microglia), CD15 (granulocytes) and CD3 (T-cells) (A). Quantification of leukocyte subsets in human... | https://api.sourcedata.io/file.php?figure_id=5253 | [
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26666269 | 10.15252/emmm.201505505 | Endothelial cell-derived Angiopoietin-2 is a therapeutic target in treatment-naive and Bevacizumab-resistant glioblastoma | 2015 | Figure 4 | <p>Figure 4: Dual anti-Ang-2 and anti-VEGF therapy acts synergistic on vascular normalization and macrophage infiltration in experimental GBM. Immunofluorescence staining of CD31 and desmin in GL261 glioblastoma after single and dual treatment with anti-Ang-2 (AMG386) and anti-VEGF (aflibercept) (A). Corresponding quan... | https://api.sourcedata.io/file.php?figure_id=5254 | [
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26666269 | 10.15252/emmm.201505505 | Endothelial cell-derived Angiopoietin-2 is a therapeutic target in treatment-naive and Bevacizumab-resistant glioblastoma | 2015 | Figure 5 | <p>Figure 5: Anti-VEGF therapy led to decreased infiltration of CD68+ macrophages in human GBM. Anti-CD68 (A), anti-CSFR1 (B) and anti-CD206 (C) immunohistochemistry of patient samples derived from treatment-naive GBM (n=24), post-radiochemotherapy (S/RTx/CTx) (n=7) and post-radiochemotherapy + bevacizumab (S/RTx/CTx/B... | https://api.sourcedata.io/file.php?figure_id=5255 | [
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26666269 | 10.15252/emmm.201505505 | Endothelial cell-derived Angiopoietin-2 is a therapeutic target in treatment-naive and Bevacizumab-resistant glioblastoma | 2015 | Figure 6 | <p>Figure 6: Bevacizumab therapy leads to reduced vessel density and increased Ang-2 expression. Immunohistochemistry stainings with antibodies directed against CD31 (A) and Ang-2 (B) in treatment-naive GBM, post-radiochemotherapy (S/RTx/CTx) and post-radiochemotherapy + bevacizumab (S/RTx/CTx/Bev) therapy are displaye... | https://api.sourcedata.io/file.php?figure_id=5256 | [
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30573670 | 10.15252/embj.201899466 | CRISPR/Cas9 searches for a protospacer adjacent motif by lateral diffusion | 2018 | Figure 3 | <sd-panel> <p><strong>Figure 3. Multiple PAM influence on binding to a target site</strong></p> <ol type="A"> <li> <p>DNA and crRNA sequence used for experiments of a single target and multiple PAMs. DNA sequence is shown for the single-target single-PAM construct and schematic representation is shown for multiple-PAM ... | https://api.sourcedata.io/file.php?figure_id=24324 | [
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30573670 | 10.15252/embj.201899466 | CRISPR/Cas9 searches for a protospacer adjacent motif by lateral diffusion | 2018 | Figure 4 | <sd-panel> <p><strong>Figure 4. Mechanism of lateral diffusion</strong></p> <ol type="A"> <li> <p>DNA sequences used in tandem target experiments. Complementary sequences to crRNA are marked in pink boxes and PAMs are marked in green boxes. Distances between the protospacers are indicated above the sequences. An illust... | https://api.sourcedata.io/file.php?figure_id=24325 | [
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10.1101/2020.03.24.005298 | A unifying structural and functional model of the coronavirus replication organelle: tracking down RNA synthesis | 2020 | Fig. 6. | <sd-panel> <p>IEM detection of viral markers in MERS-CoV-infected cells.(A-G) Immunogold labeling of thawed cryo-sections of MERS-CoV-infected Huh7 cells (12 hpi) for the detection of the indicated viral proteins. (A-C) Structural proteins were detected on virions (black arrowheads) and, for the M and S proteins, also ... | https://api.sourcedata.io/file.php?figure_id=33434 | [
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30530633 | 10.15252/embr.201846221 | Mouse fetal intestinal organoids: new model to study epithelial maturation from suckling to weaning | 2018 | Figure 2 | <sd-panel><p><strong>Figure 2</strong> - <strong>Small <sd-pretag id="sdPretag283779571sm" type="tissue" role="component">intestinal fetal</sd-pretag> organoids recapitulate suckling-to-weaning transition <em>in vitro</em></strong>.</p><p> <strong>A-G</strong> <sd-pretag id="sdPretag685066530sm" category="assay">Real... | https://api.sourcedata.io/file.php?figure_id=23969 | [
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30530633 | 10.15252/embr.201846221 | Mouse fetal intestinal organoids: new model to study epithelial maturation from suckling to weaning | 2018 | Figure 3 | <sd-panel><p><strong>Figure 3</strong> - <strong>Fetal organoids resemble adult organoids after one month in culture</strong>.</p><p> <strong>A-G</strong> Relative expression detected by <sd-pretag id="sdPretag1421187240sm" category="assay">Real</sd-pretag>-<sd-pretag id="sdPretag897429407sm" category="assay">time qP... | https://api.sourcedata.io/file.php?figure_id=23971 | [
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30530633 | 10.15252/embr.201846221 | Mouse fetal intestinal organoids: new model to study epithelial maturation from suckling to weaning | 2018 | Figure 4 | <sd-panel><p><strong>Figure 4</strong> - <strong>Dexamethasone accelerates maturation of fetal organoids.</strong></p><p> <strong>A, B, E, F</strong> Maturation is accelerated in <sd-pretag id="sdPretag749573958sm" type="molecule" role="component">dexamethasone</sd-pretag> treated fetal organoids ( ) compared to contr... | https://api.sourcedata.io/file.php?figure_id=23973 | [
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30530633 | 10.15252/embr.201846221 | Mouse fetal intestinal organoids: new model to study epithelial maturation from suckling to weaning | 2018 | Figure 5 | <sd-panel><p><strong>Figure 5</strong> - <strong><sd-pretag id="sdPretag1949810976sm" type="cell" role="component">Spheroids</sd-pretag> and <sd-pretag id="sdPretag779744354sm" type="tissue" role="component">organoids</sd-pretag> show the same protein expression pattern, independently of culture stage/passage.</stron... | https://api.sourcedata.io/file.php?figure_id=23975 | [
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10.15252/embr.202050145 | Carbonic anhydrase 7 bundles filamentous actin and regulates dendritic spine morphology and density | 2021 | Figure 1 | <sd-panel> <p><strong>Figure 1. Subcellular localization of CA7 and CA2 in fibroblasts.</strong></p> <p>(A) NIH3T3 fibroblasts co-expressing DsRed-CA7 and EGFP-CA2 (<em>n</em> = 4 independent replicates).</p> <p>(B-E) Co-localization of EGFP and the two CA isoforms with filamentous actin studied in fibroblasts expressi... | https://api.sourcedata.io/file.php?figure_id=39022 | [
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10.15252/embr.202050145 | Carbonic anhydrase 7 bundles filamentous actin and regulates dendritic spine morphology and density | 2021 | Figure 2 | <sd-panel> <p><strong>Figure 2. CA7 binds to filamentous actin and increases actin bundling.</strong></p> <p>(A) Actin co-sedimentation assay shows that CA7 binds to F-actin. The binding is enhanced at more acidic pH (6.5 vs. 7.4) <em>n</em> = 3 independent replicates at each actin concentration, two-way ANOVA, P < ... | https://api.sourcedata.io/file.php?figure_id=39024 | [
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10.15252/embr.202050145 | Carbonic anhydrase 7 bundles filamentous actin and regulates dendritic spine morphology and density | 2021 | Figure 3 | <sd-panel> <p><strong>Figure 3. CA7 overexpressing NIH3T3 are resistant to latrunculin B treatment.</strong></p> <p>(A,B) NIH3T3 cells transfected with DsRed (A) or DsRed-CA7 (B) were incubated in growth medium with 5 µM Latrunculin B for 0, 2, 5, 10, or 30 minutes, or in an equal amount of DMSO for 60 minutes. Analyse... | https://api.sourcedata.io/file.php?figure_id=39026 | [
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10.15252/embr.202050145 | Carbonic anhydrase 7 bundles filamentous actin and regulates dendritic spine morphology and density | 2021 | Figure 5 | <sd-panel> <p><strong>Figure 5. Subcellular localization of the chimeric CA7 constructs in fibroblasts.</strong></p> <p>(A-C) NIH3T3 fibroblasts expressing EGFP-CA7-mutant1 (A), EGFP-CA7-mutant2 (B), and EGFP-CA7-mutant3 (C). F-actin is visualized with Phalloidin-594. In the right-most panel of (A-C) are the normalized... | https://api.sourcedata.io/file.php?figure_id=39030 | [
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10.15252/embr.202050145 | Carbonic anhydrase 7 bundles filamentous actin and regulates dendritic spine morphology and density | 2021 | Figure 6 | <sd-panel> <p><strong>Figure 6. Localization of the overexpressed CA2 and CA7 in neurons.</strong></p> <p>(A) Isoform-specific subcellular localization shown in cultured hippocampal neurons (DIV14) co-expressing DsRed-CA7 (<em>left</em>) and EGFP-CA2 (<em>middle</em>).</p> <p>(B,C) Representative confocal images of pre... | https://api.sourcedata.io/file.php?figure_id=39032 | [
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10.15252/embr.202050145 | Carbonic anhydrase 7 bundles filamentous actin and regulates dendritic spine morphology and density | 2021 | Figure 7 | <sd-panel> <p><strong>Figure 7. Layer 2/3 cortical pyramidal neurons in CA7 KO mice have high dendritic spine density and smaller spines but mEPSC frequency and amplitude are not affected</strong></p> <p>(A) Comparison of mEPSCs in cortical layer 2/3 pyramidal neurons from P30 - P40 WT and CA7 KO mice. Sample traces of... | https://api.sourcedata.io/file.php?figure_id=39033 | [
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27110680 | 10.1038/nchembio.1230 | Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives | 2013 | figf1 | <p>(<b>a</b>) Knockdown of <named-entity id="named-entity-253">RARα</named-entity> in NIH3T3 mouse fibroblasts was conducted using two different shRNAs, sh1 and sh2, compared to control (Ctr). Left, representative immunoblot. Actin is shown as loading control and full-length blots are shown in <sir rid="S1" refobjid="n... | https://api.sourcedata.io/file.php?figure_id=3208 | [
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27110680 | 10.1038/nchembio.1230 | Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives | 2013 | figf2 | <p>(<b>a</b>) Immunoblot for <named-entity id="named-entity-259">LC3-II</named-entity> in control mouse fibroblasts (Ctr) or those knocked down for <named-entity id="named-entity-260">RARα</named-entity> (<named-entity id="named-entity-261">RARα</named-entity>(−)) maintained in the presence or absence of serum for the ... | https://api.sourcedata.io/file.php?figure_id=3209 | [
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27110680 | 10.1038/nchembio.1230 | Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives | 2013 | figf3 | <p>(<b>a</b>) Rates of degradation of long-lived proteins in mouse fibroblasts untreated (None) or treated with 40 μM <named-entity id="named-entity-268">ATRA</named-entity> and maintained in the presence or absence of serum. Values are expressed as a percentage of proteolysis; <i>n</i> = 3. (<b>b</b>) Percentage of ly... | https://api.sourcedata.io/file.php?figure_id=3210 | [
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27110680 | 10.1038/nchembio.1230 | Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives | 2013 | figf5 | <p>(<b>a</b>) Mouse fibroblasts expressing the KFERQ-mCherry1 photoactivatable reporter without (None) or with 20 μM of the indicated compounds imaged 16 h after photoactivation. Insets show higher-magnification images. Nuclei are labeled with <named-entity id="named-entity-284">DAPI</named-entity>. Scale bars, 10 μm. ... | https://api.sourcedata.io/file.php?figure_id=3212 | [
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27110680 | 10.1038/nchembio.1230 | Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives | 2013 | figf6 | <p>(<b>a</b>) Rates of degradation of long-lived proteins in control mouse fibroblasts or <named-entity id="named-entity-299">RARα</named-entity>(−) or <named-entity id="named-entity-300">LAMP-2A</named-entity>(−) (<named-entity id="named-entity-301">L-2A</named-entity>(−)) cells left untreated (None) or treated with 2... | https://api.sourcedata.io/file.php?figure_id=3213 | [
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27110680 | 10.1038/nchembio.1230 | Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives | 2013 | figf7 | <p>(<b>a</b>) Immunoblot for the indicated proteins in homogenates (Hom) and lysosomes (Lys) isolated from cells untreated (None) or treated for 12 h with 20 μM of the indicated compounds. (<b>b</b>) mRNA levels of <named-entity id="named-entity-311">LAMP-2A</named-entity> in control mouse fibroblasts (left) or <named-... | https://api.sourcedata.io/file.php?figure_id=3214 | [
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10.15252/embj.2019101996 | The N-end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin | 2019 | Figure 1 | <sd-panel> <p><strong>Figure 1. The N-end rule pathway controls LT-induced NLRP1B inflammasome activation.</strong></p> <p>A, B Effects of basic and bulky hydrophobic amino acids on LT-induced pyroptosis and caspase-1 activation in RAW<sup>RA</sup> cells. Cells were pre-treated with 10 mM indicated amino acids prior to... | https://api.sourcedata.io/file.php?figure_id=30609 | [
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10.15252/embj.2019101996 | The N-end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin | 2019 | Figure 2 | <sd-panel> <p><strong>Figure 2. The ubiquitin ligase UBR2 is required for LT-induced NLRP1B activation.</strong></p> <p>A RFP-ASC specks formation assay of the effect of <em>Ubr2</em> knockdown on LT-induced inflammasome activation. RAW<sup>RA</sup> cells were transfected with a control siRNA or <em>Ubr2</em>-targeting... | https://api.sourcedata.io/file.php?figure_id=30610 | [
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10.15252/embj.2019101996 | The N-end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin | 2019 | Figure 3 | <sd-panel> <p><strong>Figure 3. UBE2O functions together with UBR2 to mediate NLRP1B inflammasome activation.</strong></p> <p>A Immunoblotting of caspase-1 activation in Ubrs-knockdown BMDMs derived from the 129/Sv mice. Cells were transfected with the indicated siRNA for 60 h, and then treated with WT LT (+) or its E6... | https://api.sourcedata.io/file.php?figure_id=30611 | [
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10.15252/embj.2019101996 | The N-end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin | 2019 | Figure 4 | <sd-panel> <p><strong>Figure 4. LT cleavage of NLRP1B triggers N-end rule-mediated degradation of NLRP1B for inflammasome activation.</strong></p> <p>A Domain structure of NLRP1B. The LT cleavage site and the FIIND auto-cleavage site are marked.</p> <p>B Effect of LT treatment on NLRP1B protein level. 293T cells were t... | https://api.sourcedata.io/file.php?figure_id=30612 | [
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27520969 | 10.15252/emmm.201606413 | IFNλ is a Potent Anti-Influenza Therapeutic without the Inflammatory Side Effects of IFNα Treatment | 2016 | Figure 1 | <p><strong>Fig</strong><strong>ure</strong><strong> 1. Therapeutic administration of IFN</strong><strong>α and IFNλ</strong><strong> differentially influences the outcome of IAV induced disease. </strong></p>
<p><strong>A</strong>. Relative antiviral activity of IFNα (circles) or IFNλ (triangles). AEC cultures were sti... | https://api.sourcedata.io/file.php?figure_id=9576 | [
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27520969 | 10.15252/emmm.201606413 | IFNλ is a Potent Anti-Influenza Therapeutic without the Inflammatory Side Effects of IFNα Treatment | 2016 | Figure 2 | <p><strong>Fig</strong><strong>ure</strong><strong> 2. IFNα treatment correlates with increased inflammation during IAV infection. </strong></p>
<p><strong>A, B</strong><strong>.</strong> Mice were infected with PR8 and treated with IFNα (circles, 1.45μg/50μl), IFNλ (triangles, 2.6μg/50μl) or Veh Ctrl (squares) as prev... | https://api.sourcedata.io/file.php?figure_id=9577 | [
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27520969 | 10.15252/emmm.201606413 | IFNλ is a Potent Anti-Influenza Therapeutic without the Inflammatory Side Effects of IFNα Treatment | 2016 | Figure 3 | <p><strong>Fig</strong><strong>ure</strong><strong> 3. IFNα, but not IFNλ treatment induces </strong><strong>pulmonary </strong><strong>cytokine secretion through activation of immune cells. </strong></p>
<p><strong>A, B</strong><strong>.</strong> IL-6, IP-10 and MCP-1 concentrations were measured by multiplex cytokine... | https://api.sourcedata.io/file.php?figure_id=9578 | [
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27520969 | 10.15252/emmm.201606413 | IFNλ is a Potent Anti-Influenza Therapeutic without the Inflammatory Side Effects of IFNα Treatment | 2016 | Figure 4 | <p><strong>Fig</strong><strong>ure</strong><strong> 4. Pathogenicity-related gene clusters are specifically induced by IFNα, not by IFNλ treatment. </strong></p>
<p>Mice were treated with IFNα (1.45μg/50μl), IFNλ (2.6μg/50μl) or Veh Ctrl (50μl PBS), and whole lungs were taken at 18hrs post treatment for global analysis... | https://api.sourcedata.io/file.php?figure_id=9579 | [
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27520969 | 10.15252/emmm.201606413 | IFNλ is a Potent Anti-Influenza Therapeutic without the Inflammatory Side Effects of IFNα Treatment | 2016 | Figure 5 | <p><strong>Fig</strong><strong>ure</strong><strong> 5. IFNα, but not IFNλ treatment induces cytokine secretion from human immune cells. </strong></p>
<p><strong>A</strong>. Human AEC cultures were stimulated for 4hrs with IFNα (circles) or IFNλ (triangles) at specified concentrations then assessed for stated ISG induct... | https://api.sourcedata.io/file.php?figure_id=9580 | [
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27596438 | 10.15252/emmm.201505971 | ZEB1-mediated melanoma cell plasticity enhances resistance to MAPK inhibitors | 2016 | Figure 1 | <p><strong>Figure 1</strong><strong>.</strong> <strong>High </strong><strong>levels of </strong><strong>ZEB1 expression </strong><strong>are </strong><strong>correlate</strong><strong>d</strong><strong> with low </strong><strong>MITF</strong><strong> level</strong><strong>s</strong><strong> and</strong> <strong>are</st... | https://api.sourcedata.io/file.php?figure_id=9817 | [
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27596438 | 10.15252/emmm.201505971 | ZEB1-mediated melanoma cell plasticity enhances resistance to MAPK inhibitors | 2016 | Figure 2 | <p><strong>Figure </strong><strong>2</strong><strong>.</strong> <strong>High ZEB1 </strong><strong>and </strong><strong>low </strong><strong>MITF</strong><strong> level</strong><strong>s</strong> <strong>are</strong><strong> associated with inherent resistance to </strong><strong>MAPKi</strong><strong> in </strong><str... | https://api.sourcedata.io/file.php?figure_id=9818 | [
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27596438 | 10.15252/emmm.201505971 | ZEB1-mediated melanoma cell plasticity enhances resistance to MAPK inhibitors | 2016 | Figure 3 | <p><strong>Figure </strong><strong>3</strong><strong>.</strong> <strong>ZEB1 expression is activated in </strong><strong><em>BRAF</em></strong><strong><em><sup>V600</sup></em></strong><strong>-</strong><strong>mutated </strong><strong>melanoma cell lines with acquired resistance to </strong><strong>BRAFi</strong><stron... | https://api.sourcedata.io/file.php?figure_id=9819 | [
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27596438 | 10.15252/emmm.201505971 | ZEB1-mediated melanoma cell plasticity enhances resistance to MAPK inhibitors | 2016 | Figure 4 | <p><strong>Figure 4</strong><strong>.</strong> <strong><em>ZEB1</em></strong><strong> overexpression in </strong><strong>A375 </strong><strong>melanoma cell</strong><strong>s </strong><strong>potentiates </strong><strong>the conversion </strong><strong>into</strong><strong> a </strong><strong>MITF</strong><strong><sup>... | https://api.sourcedata.io/file.php?figure_id=9820 | [
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27596438 | 10.15252/emmm.201505971 | ZEB1-mediated melanoma cell plasticity enhances resistance to MAPK inhibitors | 2016 | Figure 5 | <p><strong>Figure </strong><strong>5</strong><strong>.</strong> <strong><em>ZEB1</em></strong><strong> overexpression in </strong><strong>patient-derived </strong><strong>ZEB1</strong><strong><sup>low</sup></strong><strong>/</strong><strong>MITF</strong><strong><sup>high</sup></strong><strong> short-term culture cells<... | https://api.sourcedata.io/file.php?figure_id=9821 | [
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27596438 | 10.15252/emmm.201505971 | ZEB1-mediated melanoma cell plasticity enhances resistance to MAPK inhibitors | 2016 | Figure 6 | <p><strong>Figure </strong><strong>6</strong><strong>.</strong> <strong><em>ZEB1</em></strong><strong> knock-down in </strong><strong>ZEB1</strong><strong><sup>high</sup></strong><strong>/</strong><strong>MITF</strong><strong><sup>low</sup></strong> <strong>melanoma cells promotes the </strong><strong>reversible </stro... | https://api.sourcedata.io/file.php?figure_id=9822 | [
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27596438 | 10.15252/emmm.201505971 | ZEB1-mediated melanoma cell plasticity enhances resistance to MAPK inhibitors | 2016 | Figure 7 | <p><strong>Figure </strong><strong>7</strong><strong>.</strong> <strong><em>ZEB1</em></strong><strong> knock-down </strong><strong>sensitizes </strong><strong>naive melanoma</strong> <strong>cells to </strong><strong>BRAFi</strong> <strong>and</strong> <strong>induces cell death in </strong><strong>BRAFi</strong><stron... | https://api.sourcedata.io/file.php?figure_id=9823 | [
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10.15252/embr.202154127 | Cell Communication Network factor 4 promotes tumor-induced immunosuppression in melanoma | 2022 | Figure 1 | <p><strong>Figure 1 - CCN4 is associated with reduced overall survival of patients diagnosed with primary melanoma and a shift in immune contexture.</strong></p><p>(A) Kaplan-Meier estimate of overall survival of patients diagnosed with primary melanoma stratified by CCN4 transcript abundance, with patients at risk tab... | https://api.sourcedata.io/file.php?figure_id=45764 | [
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10.15252/embr.202154127 | Cell Communication Network factor 4 promotes tumor-induced immunosuppression in melanoma | 2022 | Figure 2 | <p><strong>Figure 2 - CCN4 knockout suppressed melanoma tumor growth in immunocompetent mice.</strong></p><p>(A) CCN4 secretion after CRISPR/Cas9 knockout in B16F0 and YUMM1.7 cell lines. Cell culture media conditioned for 48 hours by the indicated cell line were tested by ELISA (n.d. = not detected). Three biological ... | https://api.sourcedata.io/file.php?figure_id=45766 | [
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10.15252/embr.202154127 | Cell Communication Network factor 4 promotes tumor-induced immunosuppression in melanoma | 2022 | Figure 3 | <p><strong>Figure 3 - CCN4 knockout increased CTL and NK effector cells and decreased MDSC in the tumor microenvironment.</strong></p><p>(A) Representative flow cytometry data of the frequency of tumor-infiltrating CD4+ and CD8+ T cells, NK effector cells, tumor-associated neutrophils (TAN) and MDSC from the live CD45+... | https://api.sourcedata.io/file.php?figure_id=45768 | [
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10.15252/embr.202154127 | Cell Communication Network factor 4 promotes tumor-induced immunosuppression in melanoma | 2022 | Figure 4 | <p><strong>Figure 4 - CCN4 expanded MDSC in the spleens of tumor bearing mice.</strong></p><p>(A-C) Tumor volume of YUMM1.7-WT and CCN4 KO (KO1) compared when size-matched and time-matched on day 28 after tumor challenge. MDSC in the spleens of tumor bearing mice expressed as percentage (B) or weight-basis (C) observed... | https://api.sourcedata.io/file.php?figure_id=45770 | [
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10.15252/embr.202154127 | Cell Communication Network factor 4 promotes tumor-induced immunosuppression in melanoma | 2022 | Figure 5 | <p><strong>Figure 5 - Knockout of CCN4 down-regulated CCL2 and CXCL1 expression and decreased glycolysis and glycolytic capacity in YUMM1.7 melanoma cells.</strong></p><p>(A) Cytokine, chemokine, and growth factor expression by YUMM1.7-WT and CCN4-KO cells in vitro assayed using R&D Systems' Mouse XL Cytokine Array... | https://api.sourcedata.io/file.php?figure_id=45772 | [
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10.15252/embr.202154127 | Cell Communication Network factor 4 promotes tumor-induced immunosuppression in melanoma | 2022 | Figure 6 | <p><strong>Figure 6 - CCN4 directly inhibited CD8</strong>+ <strong>T cell function.</strong></p><p>(A) ELISpot for IFNγ release by CD8+ T cells using parental YUMM1.7 and CCN4-KO YUMM1.7 (KO1) cells as targets and different amount of in vivo activated CD8+ T cells. Statistical significance was assessed using a Student... | https://api.sourcedata.io/file.php?figure_id=45774 | [
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10.15252/embr.202154127 | Cell Communication Network factor 4 promotes tumor-induced immunosuppression in melanoma | 2022 | Figure 7 | <p><strong>Figure 7 - CCN4 knockout further promoted the anti-tumor effect of immune checkpoint blockade therapy.</strong></p><p>(A) Average tumor volumes of mice bearing YUMM1.7-WT (squares and triangles) or CCN4-KO (KO1, circles and inverted triangles) tumors (n = 4 mice/group). Groups were treated with either αPD1 (... | https://api.sourcedata.io/file.php?figure_id=45775 | [
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10.15252/emmm.202216581 | LONP1 Targets HMGCS2 to Protect Mitochondrial Function and Attenuate Chronic Kidney Disease | 2022 | Figure 1 | <p><strong>Figure 1. LONP1 is down-regulated in the kidneys of CKD patients and mice and proximal tubular-specific overexpression of <em>Lonp1</em> alleviates renal injury and mitochondrial dysfunction in UUO model.</strong></p><p><strong>A</strong> Immunohistochemical analysis of LONP1 expression in CKD children with ... | https://api.sourcedata.io/file.php?figure_id=51727 | [
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10.15252/emmm.202216581 | LONP1 Targets HMGCS2 to Protect Mitochondrial Function and Attenuate Chronic Kidney Disease | 2022 | Figure 2 | <p><strong>Figure 2. Proximal tubular-specific deletion of <em>Lonp1</em> aggravates renal injury and mitochondrial dysfunction in UUO model.</strong></p><p><strong>A</strong> Deposition of total fibrosis in kidney tissues was determined by Masson's trichrome staining. Scale bar: 50μm.</p><p><strong>B Sirius red staini... | https://api.sourcedata.io/file.php?figure_id=51728 | [
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10.15252/emmm.202216581 | LONP1 Targets HMGCS2 to Protect Mitochondrial Function and Attenuate Chronic Kidney Disease | 2022 | Figure 3 | <p><strong>Figure 3. Proximal tubular-specific overexpression or deletion of <em>Lonp1</em> mitigated or aggravated renal injury and mitochondrial dysfunction in 5/6Nx model.</strong></p><p><strong>A Analysis of blood urea nitrogen (BUN) after 5/6Nx model in WT and cKI mice (n=6 in cKI+Sham group, n=5 in the other thre... | https://api.sourcedata.io/file.php?figure_id=51730 | [
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10.15252/emmm.202216581 | LONP1 Targets HMGCS2 to Protect Mitochondrial Function and Attenuate Chronic Kidney Disease | 2022 | Figure 4 | <p><strong>Figure 4. LONP1 attenuated TGF-β1-induced mitochondrial dysfunction and fibrotic response in HK2 cells.</strong></p><p><strong>A</strong> Quantification of mitochondrial ROS production (n=4, biological replicates).</p><p>B, C Measurement of oxygen consumption rate (OCR) using an XF96 Extracellular Flux Analy... | https://api.sourcedata.io/file.php?figure_id=51732 | [
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10.15252/emmm.202216581 | LONP1 Targets HMGCS2 to Protect Mitochondrial Function and Attenuate Chronic Kidney Disease | 2022 | Figure 5 | <p><strong>Figure 5. HMGCS2 may be the degradation substrate of LONP1.</strong></p><p>A <strong>The proximal renal tubules of <em>Lonp1</em> cKO mice were extracted and detected by mass spectrometry (n=3,</strong> biological replicates<strong>).</strong></p><p>B <strong>Subcellular localization of up-regulated proteins... | https://api.sourcedata.io/file.php?figure_id=51734 | [
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10.15252/emmm.202216581 | LONP1 Targets HMGCS2 to Protect Mitochondrial Function and Attenuate Chronic Kidney Disease | 2022 | Figure 6 | <p><strong>Figure 6. Effect of HMGCS2 on mitochondrial function and renal fibrosis.</strong></p><p>A Immunohistochemical analysis of HMGCS2 expression in CKD children. Scale bar: 50μm.</p><p>B Immunohistochemical semi-quantitative IOD analysis of HMGCS2 (n=8 in Control group, n=15 in CKD group).</p><p>C Pearson correla... | https://api.sourcedata.io/file.php?figure_id=51736 | [
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10.15252/emmm.202216581 | LONP1 Targets HMGCS2 to Protect Mitochondrial Function and Attenuate Chronic Kidney Disease | 2022 | Figure 7 | <p><strong>Figure 7. The anti-fibrotic response effect of a novel LONP1 activator in mPTC cells.</strong></p><p>A 10 high docking score molecules showed LONP1 activating effect in cell free LONP1 protease activity assay system, of which 84-B10 showed stronger activity. Bortezomib (Bor), a reported LONP1 inhibitor, is i... | https://api.sourcedata.io/file.php?figure_id=51737 | [
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23619093 | 10.1038/embor.2013.51 | Species‐specific impact of the autophagy machinery on Chikungunya virus infection | 2013 | Figure 1 | Autophagy components promote CHIKV infection and control virus‐induced cell death in HeLa cells. Cells were mock infected or infected and immunoblotted for actin, p62 (<b>A</b>) or LC3 (<b>B</b>). Cells were infected for 15 h and labeled using antibodies to p62 and capsid (<b>C</b>). Cells were transfected with GFP‐LC3... | https://api.sourcedata.io/file.php?figure_id=1691 | [
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23619093 | 10.1038/embor.2013.51 | Species‐specific impact of the autophagy machinery on Chikungunya virus infection | 2013 | Figure 2 | Autophagy receptors p62 and NDP52 localize to distinct pools of capsid and have distinct effects on CHIKV infection in Hela cells. Cells were infected for 15 h and labeled using antibodies to NDP52 and capsid (<b>A</b>), to p62, NDP52 and capsid (<b>B</b>), to NDP52, LC3‐C or capsid (<b>C</b>), to p62, ubiquitin (FK2) ... | https://api.sourcedata.io/file.php?figure_id=1692 | [
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23619093 | 10.1038/embor.2013.51 | Species‐specific impact of the autophagy machinery on Chikungunya virus infection | 2013 | Figure 3 | p62 associates with ubiquitinated capsid and controls cell death induced by cytotoxic capsid in HeLa cells. Cells were infected for 24 h and immunoprecipitation experiments were performed using antibodies to FK2, capsid or nonspecific IgG controls. Immunoprecipitated proteins were revealed using antibodies to FK2 or ca... | https://api.sourcedata.io/file.php?figure_id=1693 | [
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23619093 | 10.1038/embor.2013.51 | Species‐specific impact of the autophagy machinery on Chikungunya virus infection | 2013 | Figure 4 | Human NDP52 binds nsP2, localizes near CHIKV RCs, and restricts cell shutoff promoting cell survival in HeLa cells. Yeast cells expressing Gal4 DNA BD fused alone (empty vector) or to nsP2 were cotransformed with a plasmid encoding the Gal4 AD fused to NDP52 or the indicated NDP52 deletion mutants (top). Yeast cells ex... | https://api.sourcedata.io/file.php?figure_id=1694 | [
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23619093 | 10.1038/embor.2013.51 | Species‐specific impact of the autophagy machinery on Chikungunya virus infection | 2013 | Figure 5 | NDP52 promotes CHIKV infection in a species‐specific manner. MEF cells were treated with CTRL or NDP52 siRNA, then infected for 24 h. Cell mortality (that is, fold change relative to mock‐infected cells) (<b>A</b>) and viral production (<b>B</b>) were measured. Yeast cells expressing Gal4 DNA BD fused alone (empty vect... | https://api.sourcedata.io/file.php?figure_id=1695 | [
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29572529 | 10.1038/nn.2922 | Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons | 2011 | figf1 | <p>(<b>a</b>) The Hiw-associated complex was purified by TAP (see Online <ancref rid="an1">Methods</ancref>) and analyzed by one-dimensional SDS-PAGE gel followed by Sypro Ruby staining. Mass spectrometry identified the full-length Hiw, β-tubulin, Rae1 and Fsn, indicated by arrows. (<b>b</b>) The Rae1-associated comple... | https://api.sourcedata.io/file.php?figure_id=3685 | [
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29572529 | 10.1038/nn.2922 | Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons | 2011 | figf2 | <p>(<b>a</b>) The gene structure of <i>Rae1</i>. The black-arrowed boxes indicate exons. A transposable element, P{GawB}NP3499, located ∼400 bp upstream of the first exon of <i>Rae1</i> was used to generate imprecise excision mutants of <i>Rae1</i>. PCR analysis indicates that ∼900 bp and a ∼1.5-k bp DNA fragment in th... | https://api.sourcedata.io/file.php?figure_id=3686 | [
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29572529 | 10.1038/nn.2922 | Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons | 2011 | figf3 | <p>(<b>a</b>) Representative confocal images of segment A3 muscle 6/7 synapses stained for both DVGLUT (green) and FasII (red), in late 2<super>nd</super>/early 3<super>rd</super> instar wild-type, <i>Rae1</i><super><i>EX28</i></super>, <i>Rae1</i><super><i>EX28</i></super> presynaptic rescue (<i>Rae1</i><super><i>EX28... | https://api.sourcedata.io/file.php?figure_id=3687 | [
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29572529 | 10.1038/nn.2922 | Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons | 2011 | figf4 | <p>(<b>a</b>) Representative confocal images of muscle 4 synapses stained for both DVGLUT (green) and FasII (red) in wild-type, <i>Rae1</i><super><i>EX28</i></super><i>/</i>+, <i>hiw</i><super><i>ND51</i></super>, <i>hiw</i><super><i>ND51</i></super><i>; Rae1</i><super><i>EX28</i></super><i>/</i>+, <i>hiw</i><super><i>... | https://api.sourcedata.io/file.php?figure_id=3688 | [
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29572529 | 10.1038/nn.2922 | Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons | 2011 | figf5 | <p>(<b>a</b>) Schematic presentation of NTAP-tagged (NT-) and HM-tagged (HM-) <i>hiw</i> transgenes encoding full-length, mutated or truncated Hiw proteins. Hiw functional domains are marked with colored boxes. The positions of amino-acid substitution in NT-HiwΔRING and the added amino acid residue necessary to maintai... | https://api.sourcedata.io/file.php?figure_id=3689 | [
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29572529 | 10.1038/nn.2922 | Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons | 2011 | figf6 | <p>(<b>a</b>) Indicated NTAP-tagged <i>hiw</i> transgenes (described in <figr rid="f5">Fig. 5</figr>) and a TAP only transgene were expressed in neurons under the control of the <i>BG380-Gal4</i> driver. Larval brain lysates from each sample were subject to IgG pulldown. Both the inputs and the IgG pulldown complexes w... | https://api.sourcedata.io/file.php?figure_id=3690 | [
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29572529 | 10.1038/nn.2922 | Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons | 2011 | figf7 | <p>(<b>a</b>) Neuronal expression of neither Hiw nor Rae1 rescues the synaptic terminal overgrowth phenotype caused by the loss of function of the other gene. Quantification of the number of boutons in wild-type, <i>Rae1</i><super><i>EX28</i></super>, <i>Rae1</i><super><i>EX28</i></super><i>; Hiw</i> rescue (Res) (<i>R... | https://api.sourcedata.io/file.php?figure_id=3691 | [
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29572529 | 10.1038/nn.2922 | Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons | 2011 | figf8 | <p>(<b>a</b>) Representative confocal images of segment A3 muscle 6/7 synapses stained for both DVGLUT (green) and FasII (red), in wild-type, <i>Rae1</i><super><i>EX28</i></super>, <i>Rae1</i><super><i>EX28</i></super>; <i>atg1/</i>+, <i>Rae1</i><super><i>EX28</i></super>; <i>atg2/</i>+ and <i>Rae1</i><super><i>EX28</i... | https://api.sourcedata.io/file.php?figure_id=3692 | [
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10.15252/emmm.202012088 | BAM15 Mediated Mitochondrial Uncoupling Protects Against Obesity and Improves Glycemic Control | 2020 | Figure 1 | <sd-panel> <p><strong>Figure 1</strong>. BAM15 improves cellular respiratory kinetics by sustained mitochondrial uncoupling.</p> <p><strong>(A)</strong> Caspase 3/7 activation ± 16-hour treatment with varying concentrations of BAM15, DNP, or FCCP (N=3 per condition). 5 μM: BAM15 vs. DNP (<em>P</em>=0.030). 10 μM: BAM15... | https://api.sourcedata.io/file.php?figure_id=33098 | [
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10.15252/emmm.202012088 | BAM15 Mediated Mitochondrial Uncoupling Protects Against Obesity and Improves Glycemic Control | 2020 | Figure 3 | <sd-panel> <p><strong>Figure 3.</strong> BAM15 stimulates insulin signaling and oxidation of glucose and fatty acids in an AMPK dependent manner.</p> <p><strong>A-D (A)</strong> Representative immunoblots and <strong>(B)</strong> quantitative analysis of AKT (1 μM insulin: <em>P</em>=0.038), <strong>(C)</strong> AS160 ... | https://api.sourcedata.io/file.php?figure_id=33102 | [
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10.15252/emmm.202012088 | BAM15 Mediated Mitochondrial Uncoupling Protects Against Obesity and Improves Glycemic Control | 2020 | Figure 7 | <sd-panel> <p><strong>Figure 7.</strong> Increased skeletal muscle fatty acid oxidation is supported by AMPK mediated suppression of lipogenesis in white adipose tissue following treatment with BAM15.</p> <p><strong>A-D (A)</strong> Plasma concentrations of non-esterified fatty acids (NEFA) (CTRL N=7, BAM15 N=8, <em>P<... | https://api.sourcedata.io/file.php?figure_id=33109 | [
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10.15252/emmm.202013742 | Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype | 2021 | Figure 1 | <p>Figure 1. Accumulation of Gb3 in Batten Disease cellular models.</p><p>(A) Representative Opera images of WT and CLN3 KO ARPE 19 cell lines stained using fluorescent-conjugated cholera toxin (to detect GM1), LipidTox (to detect neutral lipids), fluorescent-conjugated Shiga toxin and is quantification (to detect Gb3)... | https://api.sourcedata.io/file.php?figure_id=42561 | [
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10.15252/emmm.202013742 | Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype | 2021 | Figure 2 | <p>Figure 2. Neural accumulation of Gb3 in brain areas of the CLN7<sup>Δex2</sup> mouse.</p><p>(A-B) Representative confocal images of Gb3 accumulation, revealed by STX staining, in brain sections from CLN7<sup>Δex2</sup> mice at 3 and 7.5 months of age compared with CLN7 WT mice. Scale bars: 80 µm.</p><p>(C-D) Gb3, Ne... | https://api.sourcedata.io/file.php?figure_id=42562 | [
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10.15252/emmm.202013742 | Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype | 2021 | Figure 3 | <p>Figure 3. Role of Gb3 in Batten Disease and identification of correctors of Gb3 accumulation.</p><p>(A) Representative confocal images and quantification of SCMAS staining within the lysosome of ARPE-19 WT and CLN3 KO upon depletion of Gb3S (siGb3S), LacCer (siLCS), and GM3s (siGM3S). (*** vs WT, °°° vs CLN3 KO siSC... | https://api.sourcedata.io/file.php?figure_id=42564 | [
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10.15252/emmm.202013742 | Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype | 2021 | Figure 4 | <p>Figure 4. Tamoxifen-mediated clearance of Gb3 is ER-independent but TFEB-dependent.</p><p>(A) Representative confocal images and Quantification of STX within the lysosome in U2-OS and HeLa cells after acute silencing of CLN3 (siCLN3) in DMSO or treated 48h with Tamoxifen. (*** vs siSCR DMSO, °°° vs siCLN3 DMSO). Dat... | https://api.sourcedata.io/file.php?figure_id=42566 | [
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10.15252/emmm.202013742 | Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype | 2021 | Figure 5 | <p>Figure 5. Tamoxifen dephosphorylates TFEB.</p><p>(A) Immunoblot analysis and quantification of pTFEB S211 in HeLa cells stably expressing TFEB-GFP. Data are presented as mean ± SD, ***: P ≤ 0.0001, as determined by ANOVA (n=3 biological replicas ). GAPDH immunoblotting was performed as a loading control.</p><p>(B) I... | https://api.sourcedata.io/file.php?figure_id=42568 | [
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10.15252/emmm.202013742 | Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype | 2021 | Figure 6 | <p>Figure 6. Tamoxifen reduce Gb3 accumulation in brain of CLN7<sup>Δex2</sup> mice.</p><p>Representative confocal images of STX in the Cortex, Hippocampus, and Cerebellum brain section derived from 7.5 months-old mouse WT or CLN7<sup>Δex2</sup> injected with vehicle or Tamoxifen (Tamox). Quantification of confocal ima... | https://api.sourcedata.io/file.php?figure_id=42570 | [
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"ext_tax_names": "Mus musculus",
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"ncbi_gene_id": "72175",
"original_type": "gene",
"role": "intervention",
"text": "CLN7",
"type": "geneprod",
... | ||
10.15252/emmm.202013742 | Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype | 2021 | Figure 7 | <p>Figure 7. Tamoxifen reduces SCMAS accumulation in the brains of CLN7<sup>Δex2</sup> mice.</p><p>Representative confocal images of SCMAS in the Cortex, Hippocampus, and Cerebellum brain section derived from mouse WT or CLN7<sup>Δex2</sup> injected with vehicle or Tamoxifen. Quantification of confocal images, the plot... | https://api.sourcedata.io/file.php?figure_id=42571 | [
{
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"ncbi_gene_id": "72175",
"original_type": "gene",
"role": "intervention",
"text": "CLN7",
"type": "geneprod",
... | ||
10.15252/emmm.202013742 | Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype | 2021 | Figure 8 | <p>Figure 8. Tamoxifen ameliorates CLN7<sup>Δex2</sup> phenotype.</p><p>(A-B) Representative confocal images and quantification of IBA-1 in the Cortex, Hippocampus, and Cerebellum brain section derived from WT or CLN7<sup>Δex2</sup> mice injected with the vehicle or Tamoxifen. (***/**/* vs WT, °°°/°°/° vs CLN7<sup>Δex2... | https://api.sourcedata.io/file.php?figure_id=42572 | [
{
"ext_dbs": "NCBI gene",
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"mapping_status": "mapped",
"ncbi_gene_id": "72175",
"original_type": "gene",
"role": "intervention",
"text": "CLN7",
"type": "geneprod",
... | ||
27242363 | 10.15252/embj.201593265 | WRNIP1 protects stalled forks from degradation and promotes fork restart after replication stress | 2016 | Figure 1 | <p><strong>Fig</strong><strong>ure</strong><strong> 1.</strong> <strong>Loss of</strong> <strong>WRNIP1 leads to nascent DNA strand degradation after HU-induced replication stress</strong></p>
<p>(<strong>A</strong>) Western blot analysis showing the expression of the WRNIP1 protein in wild-type cells (shWRNIP1<sup>WT<... | https://api.sourcedata.io/file.php?figure_id=8326 | [
{
"ext_dbs": "NCBI gene",
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"ext_tax_ids": "9606",
"ext_tax_names": "Homo sapiens",
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"mapping_status": "mapped",
"ncbi_gene_id": "56897",
"original_type": "gene",
"role": "intervention",
"text": "WRNIP1",
"type": "geneprod",... | |
27242363 | 10.15252/embj.201593265 | WRNIP1 protects stalled forks from degradation and promotes fork restart after replication stress | 2016 | Figure 2 | <p><strong>Fig</strong><strong>ure</strong> <strong>2.</strong> <strong>Inhibition of MRE11 exonuclease activity prevents nascent DNA strand degradation after replication stress </strong></p>
<p>(<strong>A</strong>) Experimental scheme of dual labelling of DNA fibers in wild-type cells (shWRNIP1<sup>WT</sup>) or WRNIP1... | https://api.sourcedata.io/file.php?figure_id=8327 | [
{
"ext_dbs": "NCBI gene",
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"ext_tax_ids": "9606",
"ext_tax_names": "Homo sapiens",
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"ncbi_gene_id": "56897",
"original_type": "gene",
"role": "intervention",
"text": "WRNIP1",
"type": "geneprod",... | |
27242363 | 10.15252/embj.201593265 | WRNIP1 protects stalled forks from degradation and promotes fork restart after replication stress | 2016 | Figure 3 | <p><strong>Fig</strong><strong>ure</strong> <strong>3. Analysis of parental ssDNA formation and RAD51 destabilization at stalled replication forks</strong></p>
<p>(<strong>A</strong>) Evaluation of ssDNA accumulation at parental-strand by immunofluorescence analysis in wild-type (shWRNIP1<sup>WT</sup>) or WRNIP1-defici... | https://api.sourcedata.io/file.php?figure_id=8328 | [
{
"ext_dbs": "NCBI gene",
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"ext_tax_ids": "9606",
"ext_tax_names": "Homo sapiens",
"mapping_source": "ncbi_gene",
"mapping_status": "mapped",
"ncbi_gene_id": "56897",
"original_type": "gene",
"role": "intervention",
"text": "WRNIP1",
"type": "geneprod",... | |
27242363 | 10.15252/embj.201593265 | WRNIP1 protects stalled forks from degradation and promotes fork restart after replication stress | 2016 | Figure 4 | <p><strong>Fig</strong><strong>ure</strong><strong> 4.</strong> <strong>RAD51 protects nascent DNA strand from degradation after fork stalling in the absence of WRNIP1 </strong></p>
<p>(<strong>A</strong>) Experimental scheme of pulse-labelling of DNA fibers in wild-type cells (shWRNIP1<sup>WT</sup>) or WRNIP1-deficien... | https://api.sourcedata.io/file.php?figure_id=8329 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "56897",
"ext_tax_ids": "9606",
"ext_tax_names": "Homo sapiens",
"mapping_source": "ncbi_gene",
"mapping_status": "mapped",
"ncbi_gene_id": "56897",
"original_type": "gene",
"role": "intervention",
"text": "WRNIP1",
"type": "geneprod",... | |
27242363 | 10.15252/embj.201593265 | WRNIP1 protects stalled forks from degradation and promotes fork restart after replication stress | 2016 | Figure 5 | <p><strong>Fig</strong><strong>ure</strong><strong> 5.</strong> <strong>WRNIP1 stabilizes RAD51 on stalled forks</strong></p>
<p>(<strong>A</strong>) Co-immunoprecipitation experiments in HEK293T cells transfected with empty vector or FLAG-WRNIP1 plasmid. Cells were treated or not with HU. After treatment, cell lysates... | https://api.sourcedata.io/file.php?figure_id=8330 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "56897",
"ext_tax_ids": "9606",
"ext_tax_names": "Homo sapiens",
"mapping_source": "ncbi_gene",
"mapping_status": "mapped",
"ncbi_gene_id": "56897",
"original_type": "gene",
"role": "intervention",
"text": "WRNIP1",
"type": "geneprod",... | |
27242363 | 10.15252/embj.201593265 | WRNIP1 protects stalled forks from degradation and promotes fork restart after replication stress | 2016 | Figure 6 | <p><strong>Fig</strong><strong>ure</strong><strong> 6.</strong> <strong>Loss of</strong> <strong>WRNIP1 or its ATPase activity results in DNA damage accumulation and enhanced chromosomal instability in response to fork stalling </strong></p>
<p>(<strong>A</strong>) Analysis of DNA damage accumulation. Wild-type (shWRNI... | https://api.sourcedata.io/file.php?figure_id=8331 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "56897",
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"ext_tax_names": "Homo sapiens",
"mapping_source": "ncbi_gene",
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"ncbi_gene_id": "56897",
"original_type": "gene",
"role": "intervention",
"text": "WRNIP1",
"type": "geneprod",... | |
10.15252/embr.202256271 | ABCB-mediated shootward auxin transport feeds into the root clock | 2023 | Figure 2 | <p><strong>Figure 2. The <em>amiR-2572</em> line has reduced auxin oscillation amplitude and LR density defects</strong>.</p><p><strong>A Luciferase image of the whole <em>WT and amiR-2572</em> seedlings after 10 min exposure to visualize the pre-branch sites in the root</strong> by <em>DR5:LUC</em> luminescence.</p><p... | https://api.sourcedata.io/file.php?figure_id=52094 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "F4KG58",
"ext_tax_ids": "3702",
"ext_tax_names": "Arabidopsis thaliana",
"mapping_source": "direct",
"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "assayed",
"text": "DR5",
"type": "geneprod",
... | ||
10.15252/embr.202256271 | ABCB-mediated shootward auxin transport feeds into the root clock | 2023 | Figure 3 | <p><strong>Figure 3. Analysis of plasma membrane localisation and cellular transport activities.</strong></p><p><em><strong>A Co-localisation of</strong> YFP-ABCB15 with P</em>ropidium Iodide (PI) in root epidermal cells of 3-day-old seedlings. A plot of the fluorescence intensity of YFP and PI along the dashed lines s... | https://api.sourcedata.io/file.php?figure_id=52095 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "Q9LHD1",
"ext_tax_ids": "3702",
"ext_tax_names": "Arabidopsis thaliana",
"mapping_source": "direct",
"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "assayed",
"text": "ABCB15",
"type": "geneprod",
... | ||
10.15252/embr.202256271 | ABCB-mediated shootward auxin transport feeds into the root clock | 2023 | Figure 4 | <p><strong><em>Figure 4.</em> ABCB15-22 contribute to shootward auxin transport for LR induction.</strong></p><p><strong>A Shootward auxin transport assay of [<sup>3</sup>H]-IAA and [<sup>14</sup>C]-BA in WT (Col-0) and <em>amiR-2572 roots</em>, mean ± SE; n = 3 (Col-0 and <em>amiR-2572; IAA</em>); n=4 (Col-0; BA) and ... | https://api.sourcedata.io/file.php?figure_id=52096 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "F4KG58",
"ext_tax_ids": "3702",
"ext_tax_names": "Arabidopsis thaliana",
"mapping_source": "direct",
"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "assayed",
"text": "DR5",
"type": "geneprod",
... | ||
10.15252/embr.202256271 | ABCB-mediated shootward auxin transport feeds into the root clock | 2023 | Figure 5 | <p><strong>Figure 5. ABCB15-22 expressed <em>in the outer layers of the root meristem.</em></strong></p><p><strong>A, B</strong> Expression pattern of <em>proABCB15:NLS-GFP-GUS</em>, <em>proABCB16:NLS-GFP-GUS</em>, <em>proABCB17:NLS-GFP-GUS</em>, <em>proABCB18:NLS-GFP-GUS</em>, and <em>proABCB22:NLS-GFP-GUS</em> expres... | https://api.sourcedata.io/file.php?figure_id=52097 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "Q9LHD1",
"ext_tax_ids": "3702",
"ext_tax_names": "Arabidopsis thaliana",
"mapping_source": "direct",
"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "assayed",
"text": "ABCB15",
"type": "geneprod",
... | ||
10.15252/embr.202256271 | ABCB-mediated shootward auxin transport feeds into the root clock | 2023 | Figure 6 | <p><strong>Figure 6. Tissue-specific silencing of ABCB15-22 impairs auxin oscillation amplitude and LR density.</strong></p><p><strong>A</strong> <em>Fluorescence of YFP-ABCB17 in the r</em>oot meristem and leaf in 3-day-old F1 crosses with WT, <em>syn-tasi-1522A#1</em> and <em>amiR-2572,</em> propidium iodide (PI) in ... | https://api.sourcedata.io/file.php?figure_id=52098 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "Q9LSJ6",
"ext_tax_ids": "3702",
"ext_tax_names": "Arabidopsis thaliana",
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"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "assayed",
"text": "ABCB17",
"type": "geneprod",
... | ||
10.15252/embr.201948483 | MicroRNA-195 controls MICU1 expression and tumor growth in ovarian cancer | 2020 | Figure 1 | <sd-panel> <p><strong>Figure 1. miR-195 and MICU1 levels are inversely related in ovarian cancer cell lines</strong></p> <p><strong>(A)</strong> CP20 and OVCAR4 cells were transfected with either non-target miRNA control (miR-CTL), miR-15a, or miR-195. 72h following transfection, cells were lysed and immunoblotted for ... | https://api.sourcedata.io/file.php?figure_id=34620 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "406948",
"ext_tax_ids": "9606",
"ext_tax_names": "Homo sapiens",
"mapping_source": "unmapped",
"mapping_status": "unmapped",
"ncbi_gene_id": "406948",
"original_type": "gene",
"role": "intervention",
"text": "miR-15a",
"type": "genepr... | ||
10.15252/embr.201948483 | MicroRNA-195 controls MICU1 expression and tumor growth in ovarian cancer | 2020 | Figure 2 | <sd-panel> <p><strong>Figure 2. Ectopic expression of miR-195 suppresses ovarian cancer clonal growth, migration and invasion</strong></p> <p><strong>(A, B)</strong> CP20, OVCAR4, and OVSAHO cells were transfected with non-target micro RNA control (miR-CTL) or miR-195, 24 h post-transfection, cells were recounted and p... | https://api.sourcedata.io/file.php?figure_id=34622 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "406971",
"ext_tax_ids": "9606",
"ext_tax_names": "Homo sapiens",
"mapping_source": "unmapped",
"mapping_status": "unmapped",
"ncbi_gene_id": "406971",
"original_type": "gene",
"role": "intervention",
"text": "miR-195",
"type": "genepr... | ||
10.15252/embr.201948483 | MicroRNA-195 controls MICU1 expression and tumor growth in ovarian cancer | 2020 | Figure 3 | <sd-panel> <p><strong>Figure 3. MICU1 is a direct target of miR-195</strong></p> <p><strong>(A)</strong> The miR-195 binding site as predicted by TargetScan.</p> <p><strong>(B)</strong> MICU1 3'UTR in LightSwitch™ 3′UTR Reporter Vector (wild type or miR-195 binding site deleted) was co-transfected with either non- targ... | https://api.sourcedata.io/file.php?figure_id=34624 | [
{
"ext_dbs": "NCBI gene",
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"ext_tax_names": "Homo sapiens",
"mapping_source": "ncbi_gene",
"mapping_status": "mapped",
"ncbi_gene_id": "10367",
"original_type": "gene",
"role": "assayed",
"text": "MICU1",
"type": "geneprod",
"... |
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