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27113762 | 10.15252/embr.201541643 | SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense | 2016 | Figure 4 | <p><strong>Figure 4. SIRT5 </strong><strong>desuccinylase</strong><strong> activity, but not its expression, is regulated by oxidative stimuli</strong></p>
<p><strong>(A-B) </strong>SIRT5 expression is not affected by chemical oxidant treatment. HEK293T cells were treated with Paraquat (A) or H<sub>2</sub>O<sub>2</sub>... | https://api.sourcedata.io/file.php?figure_id=7263 | [
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"... | |
10.15252/embr.202051632 | N(6)-methyladenosine-binding protein YTHDF1 suppresses EBV replication and promotes EBV RNA decay | 2021 | Figure 2 | <p><strong>Figure 2. The BZLF1 mRNA is m<sup>6</sup>A modified</strong></p><p><strong>A.</strong> m<sup>6</sup>A peak distribution of <em>BZLF1</em> in different EBV infection stages was analyzed based on MeRIP-seq data. The data presented from the top down are the EBV acute infected (24 hpi) NPEC1-Bmi1 sphere-like cel... | https://api.sourcedata.io/file.php?figure_id=42476 | [
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10.15252/embr.202051632 | N(6)-methyladenosine-binding protein YTHDF1 suppresses EBV replication and promotes EBV RNA decay | 2021 | Figure 3 | <p><strong>Figure 3. Knockdown of YTHDF1 promotes EBV infection and replication</strong></p><p><strong>A.</strong> The knockdown efficiency of <em>METTL3</em>, <em>METTL14</em>, <em>FTO</em>, <em>YTHDF1</em>, <em>YTHDF2</em> and <em>YTHDF3</em> in HK1 and CNE2EBV cells at 24 h after siRNA transfection was determined by... | https://api.sourcedata.io/file.php?figure_id=42477 | [
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10.15252/embr.202051632 | N(6)-methyladenosine-binding protein YTHDF1 suppresses EBV replication and promotes EBV RNA decay | 2021 | Figure 4 | <p><strong>Figure 4. YTHDF1 knockdown promotes the expression of BZLF1 and BRLF1</strong></p><p><strong>A.</strong> The relative mRNA levels of <em>BZLF1</em> and <em>BRLF1</em> at 24 hpi following EBV infection of HK1 cells transfected with the YTHDF1-specific siRNAs (siY1-1 and siY1-2) or the siNC control. After 24 h... | https://api.sourcedata.io/file.php?figure_id=42478 | [
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10.15252/embr.202051632 | N(6)-methyladenosine-binding protein YTHDF1 suppresses EBV replication and promotes EBV RNA decay | 2021 | Figure 5 | <p><strong>Figure 5. Knockdown of YTHDF1 prolongs the half-life of EBV transcripts</strong></p><p><strong>A</strong>, <strong>B.</strong> The relative YTHDF1-RIP enrichment ratio of the indicated genes in C666 cells (<strong>A</strong>) and CNE2EBV cells with induced EBV reactivation (24 h post TPA/NaB treatment) (<str... | https://api.sourcedata.io/file.php?figure_id=42479 | [
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10.15252/embr.202051632 | N(6)-methyladenosine-binding protein YTHDF1 suppresses EBV replication and promotes EBV RNA decay | 2021 | Figure 6 | <p><strong>Figure 6. YTHDF1 interacts with the RNA degradation complex</strong></p><p><strong>A.</strong> The interaction partners of YTHDF1 were identified by pull-down assays and mass spectrometry. The Flag-YTHDF1 pull-down assay was performed in CNE2EBV cells transfected with a plasmid encoding Flag-tagged YTHDF1. T... | https://api.sourcedata.io/file.php?figure_id=42480 | [
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10.15252/embr.202051632 | N(6)-methyladenosine-binding protein YTHDF1 suppresses EBV replication and promotes EBV RNA decay | 2021 | Figure 7 | <p><strong>Figure 7. YTHDF1 promotes viral mRNA decapping by recruiting the RNA degradation complex</strong></p>
<p><strong>A.</strong> The ratios of GFP-positive HK1 cells transfected with the ZAP-, DDX17- and DCP2-specific siRNAs or the siNC control were quantified using FACS. At 24 h post siRNA transfection, the pro... | https://api.sourcedata.io/file.php?figure_id=42481 | [
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10.15252/embj.2021108780 | Schwann cell precursors represent a neural crest-like state
with biased multipotency | 2022 | Figure 4 | <p><strong>Fig. 4. CRISP-Cas9-mediated knock-down of <em>Sox8</em> in developing chicken late neural crest affects migration and differentiation of "hub" cells.</strong></p><p><strong>A)</strong> Electroporation of the control CRISPR-Cas9 plasmid (CITRINE+ cells) does not affect <em>Sox8</em> expression as seen by HCR ... | https://api.sourcedata.io/file.php?figure_id=48473 | [
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10.15252/embr.201847047 | Cerebrovascular endothelial cells form transient Notch-dependent cystic structures in zebrafish | 2019 | Figure 3 | <sd-panel> <p><strong>Figure 3| Endothelial <em>kugeln</em> are non-nucleated with a filamenteous actin-enriched neck.</strong></p> <p><strong>A</strong> Double transgenic visualizing endothelial <sd-pretag id="sdPretag182334032sm" type="subcellular" role="component">membrane</sd-pretag> (red) and endothelial <sd-pret... | https://api.sourcedata.io/file.php?figure_id=25968 | [
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10.15252/embr.201847047 | Cerebrovascular endothelial cells form transient Notch-dependent cystic structures in zebrafish | 2019 | Figure 4 | <sd-panel> <p><strong>Figure 4 | The relationship between endothelial kugeln and <sd-pretag id="sdPretag1480722133sm" type="tissue" role="component">blood</sd-pretag> flow</strong></p> <p><strong>A</strong> MIP of the <sd-pretag id="sdPretag541240313sm" type="tissue" role="component">cerebral vessels</sd-pretag> of a... | https://api.sourcedata.io/file.php?figure_id=25970 | [
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10.15252/embr.201847047 | Cerebrovascular endothelial cells form transient Notch-dependent cystic structures in zebrafish | 2019 | Figure 5 | <sd-panel> <p><strong>Figure 5| <sd-pretag id="sdPretag89594574sm" type="geneprod" role="component"><em>Kugeln</em></sd-pretag> do not interact with <sd-pretag id="sdPretag1379500191sm" type="tissue" role="component">brain lymphatic</sd-pretag> <sd-pretag id="sdPretag189599298sm" type="cell" role="component">endothe... | https://api.sourcedata.io/file.php?figure_id=25972 | [
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10.15252/embr.201847047 | Cerebrovascular endothelial cells form transient Notch-dependent cystic structures in zebrafish | 2019 | Figure 7 | <sd-panel> <p><strong>Figure 7| <em>Kugel</em> number is increased by VEGF inhibition, and <em>kugeln</em> contain NO.</strong></p> <p><strong>A</strong> VEGF inhibition by 2h treatment with AV951 statistically significantly increased <em>kugel</em> number (****p<0.0001; DMSO control n=30 embryos 8.53 ± 2.62 (mean ±... | https://api.sourcedata.io/file.php?figure_id=25974 | [
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10.15252/embr.201847047 | Cerebrovascular endothelial cells form transient Notch-dependent cystic structures in zebrafish | 2019 | Figure 8 | <sd-panel> <p><strong>Figure 8| <em>Kugel</em> number is decreased by Notch inhibition but increased by Wnt inhibition or activation.</strong></p> <p><strong>A</strong> <em>Kugel</em> number was significantly decreased by inhibition of Notch signalling by 12h treatment with 50µM DAPT (****p<0.0001; control n=24 embr... | https://api.sourcedata.io/file.php?figure_id=25975 | [
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10.15252/emmm.201910419 | Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing ara-C efficacy | 2019 | Figure 1 | <sd-panel> <p><strong>Figure 1 | RNR inhibitor and ara-C synergy is dependent upon functional SAMHD1 in cancer cell models.</strong></p> <ol type="A"> <li> <p>Schematic detailing proposed interplay between RNR and SAMHD1.</p> </li> <li> <p>Immunoblot of lysates prepared from the indicated SAMHD1-proficient (<sup>+/+</s... | https://api.sourcedata.io/file.php?figure_id=29606 | [
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"text": "SAMHD1",
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10.15252/emmm.201910419 | Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing ara-C efficacy | 2019 | Figure 2 | <sd-panel> <p><strong>Figure 2 | RNR inhibition overcomes the SAMHD1-mediated barrier to ara-C in AML mouse models</strong></p> <ol type="A"> <li> <p>Kaplan-Meier analysis of NOD/SCID mice injected i.v. with luciferase-expressing SAMHD1<sup>+/+</sup> or <sup>-/-</sup> THP-1 cell clones (day 0) and treated with ara-C an... | https://api.sourcedata.io/file.php?figure_id=29610 | [
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10.15252/emmm.201910419 | Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing ara-C efficacy | 2019 | Figure 3 | <sd-panel> <p><strong>Figure 3 | Figure 3 | RNR inhibition enhances ara-C efficacy in primary patient AML blasts in a SAMHD1-dependant manner</strong></p> <ol type="A"> <li> <p>Drug synergy plots for ara-C and HU or dF-dC in primary patient-derived AML blasts. Each data point indicates an average delta score from a sin... | https://api.sourcedata.io/file.php?figure_id=29614 | [
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10.15252/emmm.201910419 | Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing ara-C efficacy | 2019 | Figure 4 | <sd-panel> <p><strong>Figure 4 | dCTPαS-activated SAMHD1 is a poor ara-CTPase</strong></p> <ol type="A"> <li> <p>Intracellular dNTP measurements using a primer-extension assay in SAMHD1<sup>+/+</sup> THP-1 cells treated for 4 or 24 h with either 50 µM HU (middle panel) or 2.5 nM 3-AP (right panel), ratios of dCTP-to-dA... | https://api.sourcedata.io/file.php?figure_id=29617 | [
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10.15252/embr.201847533 | Temporal Activation of LRH-1 and RAR-γ in Human Pluripotent Stem Cells Induces a Functional Naïve-Like State | 2020 | Figure 1 | <sd-panel> <p><strong>Figure 1. 2a2iL induces conversion of primed hPSCs into a naïve-like state.</strong></p> <p>A Determination of a time window for 2a2iL treatment needed to induce a naïve-like pluripotency state in primed hPSCs. One day treatment with 2a followed by the addition of 2a2iL for up to 14 days. Scale ba... | https://api.sourcedata.io/file.php?figure_id=34462 | [
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10.15252/embr.201847533 | Temporal Activation of LRH-1 and RAR-γ in Human Pluripotent Stem Cells Induces a Functional Naïve-Like State | 2020 | Figure 2 | <sd-panel> <p><strong>Figure 2. 2a2iL-hPSCs show characteristics of naïve pluripotency.</strong></p> <p>A Doubling time in pRH6 versus 2a2iL-RH6. <sup>**</sup>P<0.01 (t-test). Data presented as mean ± SD (n=3).</p> <p>B Cloning efficiency in the presence (+) and absence (−) of ROCK inhibitor (ROCKi) in pRH6 versus 2... | https://api.sourcedata.io/file.php?figure_id=34464 | [
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10.15252/embr.201847533 | Temporal Activation of LRH-1 and RAR-γ in Human Pluripotent Stem Cells Induces a Functional Naïve-Like State | 2020 | Figure 3 | <sd-panel> <p><strong>Figure 3. Functional pluripotency assessment of 2a2iL-hPSCs.</strong></p> <p>A Phase contrast images of embryoid bodies (EBs) from 2a2iL-RH6 cells that differentiated into neurons. Scale bars: 200 and 100 µm in the inset.</p> <p>B qRT-PCR analysis of 20 day-EBs from pRH6 and 2a2iL-RH6 for markers ... | https://api.sourcedata.io/file.php?figure_id=34466 | [
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10.15252/embr.201847533 | Temporal Activation of LRH-1 and RAR-γ in Human Pluripotent Stem Cells Induces a Functional Naïve-Like State | 2020 | Figure 4 | <sd-panel> <p><strong>Figure 4. 2a2iL allows derivation of naïve-like hESCs from human blastocysts</strong></p> <p>A Schematic overview of protocols used to derive naïve-like hESC lines by 2a2iL from human blastocysts. Two protocols were used to generate naïve hESC lines. In protocol 1, isolated ICMs were cultured in h... | https://api.sourcedata.io/file.php?figure_id=34468 | [
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10.15252/embr.201847533 | Temporal Activation of LRH-1 and RAR-γ in Human Pluripotent Stem Cells Induces a Functional Naïve-Like State | 2020 | Figure 7 | <sd-panel> <p><strong>Figure 7. TGFβ-2iL converts primed hPSCs to the naïve state.</strong></p> <p>A qRT-PCR analysis of ligands associated with TGF-β signaling during conversion of primed to naïve-like pluripotency by 2a2iL induction protocol at days 1, 3, and 5. 2iL was selected as a control group. <sup>***</sup>P<... | https://api.sourcedata.io/file.php?figure_id=34473 | [
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10.15252/embr.202255536 | STING agonism turns human T cells into interferon-producing cells but impedes their functionality | 2023 | Figure 1 | <h2 id="figure-1.-cgamp-treatment-in-addition-with-tcr-stimulation-leads-to-antiviral-cytokine-release-in-primary-human-t-cells">Figure 1. cGAMP treatment in addition with TCR stimulation leads to antiviral cytokine release in primary human T cells</h2><ol type="A"> <li> <p>CD4 and CD8 T cells were stimulated with cGAM... | https://api.sourcedata.io/file.php?figure_id=52046 | [
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10.15252/embr.202255536 | STING agonism turns human T cells into interferon-producing cells but impedes their functionality | 2023 | Figure 2 | <h2 id="figure-2.-primary-human-t-cells-display-canonical-sting-signaling">Figure 2. Primary human T cells display canonical STING signaling</h2><ol type="A"> <li> <p>Pooled CD4 T cell WT and <em>STING1</em><sup>-/-</sup> clones were stimulated in triplicates with cGAMP (20 μg/ml) and αCD3/CD28 for 4 h and analyzed by ... | https://api.sourcedata.io/file.php?figure_id=52048 | [
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10.15252/embr.202255536 | STING agonism turns human T cells into interferon-producing cells but impedes their functionality | 2023 | Figure 3 | <h2 id="figure-3.-critical-role-for-nf-kb-signaling-in-sting-driven-antiviral-immunity">Figure 3. Critical role for NF-kB signaling in STING-driven antiviral immunity</h2><ol type="A"> <li> <p>Simplified model of signaling downstream of TCR engagement.</p> </li> <li> <p>CD4 T cells were pre-treated with Dasatinib (100,... | https://api.sourcedata.io/file.php?figure_id=52050 | [
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10.15252/embr.202255536 | STING agonism turns human T cells into interferon-producing cells but impedes their functionality | 2023 | Figure 4 | <h2 id="figure-4.-sting-activation-induces-cell-death-in-primary-human-t-cells.">Figure 4. STING activation induces cell death in primary human T cells.</h2><ol type="A"> <li> <p>Freshly isolated CD4 T cells were treated with cGAMP, αCD3/CD28 beads and ABT737/S63845 (A/S) for 48 h and analyzed by flow cytometry. Treatm... | https://api.sourcedata.io/file.php?figure_id=52052 | [
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10.15252/embr.202255536 | STING agonism turns human T cells into interferon-producing cells but impedes their functionality | 2023 | Figure 5 | <h2 id="figure-5.-sting-activation-impairs-proliferation-in-primary-human-t-cells.">Figure 5. STING activation impairs proliferation in primary human T cells.</h2><ol type="A"> <li> <p>CellTrace Violet (CTV) stained, freshly isolated CD4 and CD8 T cells were activated with αCD3/CD28 beads, stimulated with cGAMP for 96 ... | https://api.sourcedata.io/file.php?figure_id=52054 | [
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10.15252/embj.2022111473 | BRD4-PRC2 Represses Transcription of T-helper 2-Specific Negative Regulators during T-cell Differentiation | 2023 | Figure 1 | <p><strong>Fig. 1. Brd4 represses a key gene transcriptional program during Th2 cell differentiation.</strong></p><p><em>(A)</em> Volcano plot of RNA-seq data showing differential expression of mRNA transcripts in mouse Th2 cells treated with or without JQ1 (250nM). Data are representative of two biological replicates.... | https://api.sourcedata.io/file.php?figure_id=52270 | [
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10.15252/embj.2022111473 | BRD4-PRC2 Represses Transcription of T-helper 2-Specific Negative Regulators during T-cell Differentiation | 2023 | Figure 2 | <p><strong>Fig. 2. Foxp3 inhibits <em>Gata3</em> gene transcription while <em>Fbxw7</em> promotes Gata3 protein degradation.</strong> <em>(A)</em> ATAC-seq tracks of accessible <em>cis</em>-regulatory regions of <em>Foxp3</em>, <em>Fbxw7, Gata3, and Il4-13</em> in mouse naïve, Th1, Th2, Th17 and Treg cells.</p><p><em>(... | https://api.sourcedata.io/file.php?figure_id=52272 | [
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10.15252/embj.2022111473 | BRD4-PRC2 Represses Transcription of T-helper 2-Specific Negative Regulators during T-cell Differentiation | 2023 | Figure 3 | <p><strong>Fig. 3. Brd4 recruits PRC2 subunits to repress Th2 negative regulators through H3K27me3.</strong></p><p><em><strong>(A)</strong></em> ChIP-seq tracks of Gata3 and Brd4 co-occupancy on the gene loci of <em>Il4</em>, <em>Il5</em>, <em>Il13, Foxp3</em> and <em>Fbxw7</em> in mouse Th2 cells.</p><p><em>(B)</em> C... | https://api.sourcedata.io/file.php?figure_id=52274 | [
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10.15252/embj.2022111473 | BRD4-PRC2 Represses Transcription of T-helper 2-Specific Negative Regulators during T-cell Differentiation | 2023 | Figure 4 | <p><strong>Fig. 4. Brd4-BD2 binds acetylated-EED to repress <em>Foxp3</em> and <em>Fbxw7</em> in Th2 cells.</strong></p><p><em>(A)</em> Immunoprecipitation of Flag-tagged Brd4, followed by Western blotting of HA to detect HA-Ezh2, HA-EED and HA-Suz12 in HEK293T cells transfected with Flag-Brd4 and/or HA-Ezh2, HA-EED an... | https://api.sourcedata.io/file.php?figure_id=52276 | [
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10.15252/embj.2022111473 | BRD4-PRC2 Represses Transcription of T-helper 2-Specific Negative Regulators during T-cell Differentiation | 2023 | Figure 5 | <p><strong>Fig. 5. Brd4 through its BD2 domain regulates transcription of Th2-key genes and -negative regulators.</strong></p><p><em>(A)</em> Flow cytometric (<em>left</em>) and statistical analysis (<em>right</em>) of IL-4 and IL-17A in mouse Th2 and Th17 cells treated with BRD4 BD2-selective inhibitor ABBV-744 (1μM) ... | https://api.sourcedata.io/file.php?figure_id=52278 | [
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10.15252/emmm.201911589 | Metabolic effects of bezafibrate in mitochondrial disease | 2020 | Figure 2 | <sd-panel> <p><strong>Figure 2. Metabolic effects of bezafibrate in patients with the m.3243A>G <em>MTTL1</em> mutation.</strong></p> <p>W0, W6 and W12 refer to the week of study.</p> <p>(<strong>A</strong>) Serum FGF-21 and GDF-15 levels before, during and after treatment (two-sided Wilcoxon signed-rank test, <em>P... | https://api.sourcedata.io/file.php?figure_id=29958 | [
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10.15252/emmm.201911589 | Metabolic effects of bezafibrate in mitochondrial disease | 2020 | Figure 3 | <sd-panel> <p><strong>Figure 3. Mitochondrial biogenesis and clinical effects of bezafibrate in patients with the m.3243A>G <em>MTTL1</em> mutation.</strong></p> <p>P1 - P6 refer to individual patients.</p> <p>(<strong>A</strong>) Representative examples of the quadruple immunofluorescence quantification of skeletal... | https://api.sourcedata.io/file.php?figure_id=29960 | [
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10.15252/embr.202254859 | UBXD8 mediates mitochondria-associated degradation to restrain apoptosis and mitophagy | 2022 | Figure 1 | <sd-panel><p><strong>Figure 1. UBXD8 dually localizes to mitochondria and the ER.</strong></p> <ol type="A"> <li> <p>Schematic of the domain structure and membrane topology of UBXD8, UBXD2, and UBXD6. UBA: <span class="underline">ub</span>iquitin-<span class="underline">a</span>ssociated; HP: hairpin; UAS: <span class=... | https://api.sourcedata.io/file.php?figure_id=49132 | [
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10.15252/embr.202254859 | UBXD8 mediates mitochondria-associated degradation to restrain apoptosis and mitophagy | 2022 | Figure 2 | <sd-panel><p><strong>Figure 2. UBXD8 associates with mitochondrial and ER ubiquitin E3 ligases and recruits VCP to mitochondria and the ER<em>.</em></strong></p> <ol type="A"> <li> <p>Blue native gel analysis of UBXD8 in mitochondrial fractions purified from WT and ∆UBXD8 HeLa cells.</p> </li> <li> <p>Immunoprecipitati... | https://api.sourcedata.io/file.php?figure_id=49134 | [
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10.15252/embr.202254859 | UBXD8 mediates mitochondria-associated degradation to restrain apoptosis and mitophagy | 2022 | Figure 3 | <sd-panel><p><strong>Figure 3. Both UBXD8 and UBXD2 (ER VCP adaptor) participate in mitochondrial protein degradation.</strong></p> <p>A, B. Western blot (A) and quantitative (B) analyses of MiD49 and Mcl1 degradation in WT and ∆MARCH5 HeLa cells. Cycloheximide (CHX: 200 μg/ml; protein synthesis inhibitor); MG132: 20 μ... | https://api.sourcedata.io/file.php?figure_id=49136 | [
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10.15252/embr.202254859 | UBXD8 mediates mitochondria-associated degradation to restrain apoptosis and mitophagy | 2022 | Figure 4 | <sd-panel><p><strong>Figure 4. UBXD8 degrades mitochondrial and ER substrates <em>in cis</em> and <em>in trans.</em></strong></p> <ol type="A"> <li> <p><strong>Schematic of mito-UBXD8 and ER-UBXD8.</strong></p> </li> </ol> <ol start="2" type="A"> <li> <p><strong>Fractionation analysis of the subcellular localization of... | https://api.sourcedata.io/file.php?figure_id=49138 | [
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10.15252/embr.202254859 | UBXD8 mediates mitochondria-associated degradation to restrain apoptosis and mitophagy | 2022 | Figure 5 | <sd-panel><p><strong>Figure 5. UBXD8 knockout sensitizes cells to mitochondrial stresses and apoptotic insults.</strong></p> <p>A-C, Growth tests of the indicated HeLa cells in response to oligomycin (A), chloramphenicol (B), and ethidium bromide (EB) (C) treatment. Oligo: 10 μM; Chloramphenicol: 300 μg/ml; EB: 50 ng/m... | https://api.sourcedata.io/file.php?figure_id=49140 | [
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10.15252/embr.202254859 | UBXD8 mediates mitochondria-associated degradation to restrain apoptosis and mitophagy | 2022 | Figure 6 | <sd-panel><p><strong>Figure 6. UBXD8 mediates the degradation of multiple BH3-only proteins and restrains apoptosis via Noxa degradation.</strong></p> <ol type="A"> <li> <p>Western blot analysis of BH3-domain containing proteins in the indicated HeLa cells treated with Doxo (10 μM). Three proteins with enhanced level i... | https://api.sourcedata.io/file.php?figure_id=49142 | [
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10.15252/embr.201847498 | DDX3X and Specific Initiation Factors Modulate FMR1 Repeat-Associated Non-AUG Initiated translation | 2019 | Figure 2 | <sd-panel> <p><strong>Figure 2. Knockdown of <em>Belle</em> Mitigates Repeat-Associated Toxicity by Inhibiting RAN Translation in <sd-pretag id="sdPretag1082730050sm" type="organism" role="component"><em>Drosophila</em></sd-pretag>.</strong></p> <p>A Representative photographs of fly <sd-pretag id="sdPretag1565301136s... | https://api.sourcedata.io/file.php?figure_id=27035 | [
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10.15252/embr.201847498 | DDX3X and Specific Initiation Factors Modulate FMR1 Repeat-Associated Non-AUG Initiated translation | 2019 | Figure 3 | <sd-panel> <p><strong>Figure 3. Knockdown of <sd-pretag id="sdPretag1668622231sm" type="geneprod" role="intervention"><em>DDX3X</em></sd-pretag> Inhibits RAN Translation in Cultured <sd-pretag id="sdPretag782749662sm" type="organism" role="component">Human</sd-pretag> Cells.</strong></p> <p>A Dose-response <sd-pretag... | https://api.sourcedata.io/file.php?figure_id=27036 | [
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10.15252/embr.201847498 | DDX3X and Specific Initiation Factors Modulate FMR1 Repeat-Associated Non-AUG Initiated translation | 2019 | Figure 4 | <sd-panel> <p><strong>Figure 4. DDX3X Facilitates Expression of <sd-pretag id="sdPretag508316366sm" type="geneprod" role="assayed">RAN</sd-pretag> Products at the Level of Translation.</strong></p> <p>A Expression of <em>in vitro</em> transcribed AUG, +1 (CGG)<sub>100</sub>, and +2 (CGG)<sub>100</sub> NL-3xF RNAs foll... | https://api.sourcedata.io/file.php?figure_id=27037 | [
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10.15252/embr.201847498 | DDX3X and Specific Initiation Factors Modulate FMR1 Repeat-Associated Non-AUG Initiated translation | 2019 | Figure 5 | <sd-panel> <p><strong>Figure 5. <sd-pretag id="sdPretag550296914sm" type="geneprod" role="component"><em>EIF4B</em></sd-pretag> and <sd-pretag id="sdPretag1005320249sm" type="geneprod" role="intervention"><em>EIF4H</em></sd-pretag> Modulate <sd-pretag id="sdPretag947937145sm" type="organism" role="component">RAN</sd... | https://api.sourcedata.io/file.php?figure_id=27038 | [
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10.15252/embr.201847498 | DDX3X and Specific Initiation Factors Modulate FMR1 Repeat-Associated Non-AUG Initiated translation | 2019 | Figure 6 | <sd-panel> <p><strong>Figure 6: <sd-pretag id="sdPretag1603045256sm" type="geneprod" role="assayed"><em>EIF1</em></sd-pretag> and <em><sd-pretag id="sdPretag1316234507sm" type="geneprod" role="component">EIF5</sd-pretag> m</em>odulate RAN translation by determining AUG start-codon specificity.</strong></p> <p>A Expre... | https://api.sourcedata.io/file.php?figure_id=27039 | [
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10.15252/embr.201847498 | DDX3X and Specific Initiation Factors Modulate FMR1 Repeat-Associated Non-AUG Initiated translation | 2019 | Figure 7 | <sd-panel> <p><strong>Figure 7. Knockdown of <sd-pretag id="sdPretag589387707sm" type="geneprod" role="intervention"><em>DDX3X</em></sd-pretag> Mitigates (CGG)<sub>100</sub> Toxicity in Primary Rodent <sd-pretag id="sdPretag927719484sm" type="cell" role="component">Neurons</sd-pretag>.</strong></p> <p>A Sample microg... | https://api.sourcedata.io/file.php?figure_id=27040 | [
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10.15252/embr.202050287 | Scaf1 promotes respiratory supercomplexes and metabolic efficiency in zebrafish | 2020 | Figure 1 | <sd-panel> <p><strong>Figure 1. OXPHOS super-assembly in zebrafish.</strong></p> <p><strong>A-D</strong>, Blue native gel electrophoresis <strong>(</strong>BNGdataE) of mouse (M) C57BL/6J (111), CD1 (113) and zebrafish (ZF) skeletal muscle digitonin-solubilized mitochondria. (<strong>A, B</strong>) Immunodetection of t... | https://api.sourcedata.io/file.php?figure_id=32965 | [
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10.15252/embr.202050287 | Scaf1 promotes respiratory supercomplexes and metabolic efficiency in zebrafish | 2020 | Figure 2 | <sd-panel> <p><strong>Figure 2. Blue-DiS proteomics of <em>scaf1</em><sup>+/+</sup> and <em>scaf1</em><sup>-/-</sup>.</strong></p> <p><strong>A</strong>, Quantitative data-independent scanning (DiS) mass spectrometry protein profiles for CI, CIII and CIV. Vertical numbers indicate the BNGE gel slices. Left and right pr... | https://api.sourcedata.io/file.php?figure_id=32967 | [
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10.15252/embr.202050287 | Scaf1 promotes respiratory supercomplexes and metabolic efficiency in zebrafish | 2020 | Figure 3 | <sd-panel> <p><strong>Figure 3. Phenotype consequences of Scaf1 loss-of-function.</strong></p> <p><strong>A, B,</strong> Representative images from <em>scaf1</em><sup>+/+</sup> and <em>scaf1</em><sup>-/-</sup> (<strong>A</strong>) female and (<strong>B</strong>) male adult zebrafish.</p> <p><strong>c-f,</strong> Size o... | https://api.sourcedata.io/file.php?figure_id=32969 | [
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10.15252/embr.202050287 | Scaf1 promotes respiratory supercomplexes and metabolic efficiency in zebrafish | 2020 | Figure 4 | <sd-panel> <p><strong>Figure 4. Scaf1 loss-of-function leads to alterations in mitochondrial structure and performance.</strong></p> <p><strong>A-C</strong>, Transmission electron microscopy image of cardiac muscle from <em>scaf1</em><sup>Δ1/Δ1</sup> (n=3) and <em>scaf1</em><sup>+/+</sup> fish (n=3). (<strong>A</strong... | https://api.sourcedata.io/file.php?figure_id=32971 | [
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10.15252/embr.202050287 | Scaf1 promotes respiratory supercomplexes and metabolic efficiency in zebrafish | 2020 | Figure 5 | <sd-panel> <p><strong>Figure 5. Diet-induced recovery of <em>scaf1</em><sup>-/-</sup> phenotypes</strong>.</p> <p>Data from females.</p> <p><strong>A</strong>, Representative images of <em>scaf1</em><sup>-/-</sup> and <em>scaf1</em><sup>+/+</sup> fish fed with the indicated diets.</p> <p><strong>B, C</strong>, Changes ... | https://api.sourcedata.io/file.php?figure_id=32973 | [
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10.15252/embr.202050287 | Scaf1 promotes respiratory supercomplexes and metabolic efficiency in zebrafish | 2020 | Figure 6 | <sd-panel> <p><strong>Figure 6. Lack of recovery of Scaf1<sup>-/-</sup> phenotypes after high-fat diet.</strong></p> <p><strong>A, B,</strong> Representative images of <em>scaf1</em><sup>-/-</sup> and <em>scaf1</em><sup>+/+</sup> females (<strong>A</strong>) and males (<strong>B</strong>) fed with the indicated diets.<... | https://api.sourcedata.io/file.php?figure_id=32975 | [
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10.15252/embr.202050287 | Scaf1 promotes respiratory supercomplexes and metabolic efficiency in zebrafish | 2020 | Figure 7 | <sd-panel> <p><strong>Figure 7. Molecular basis for diet-induced recovery of <em>scaf1</em><sup>-/-</sup> phenotypes.</strong></p> <p><strong>A,</strong> Immunoblot of the indicated proteins of BNGE from female <em>scaf1</em><sup>+/+</sup> and <em>scaf1</em><sup>-/-</sup> whole zebrafish mitochondria for the indicated ... | https://api.sourcedata.io/file.php?figure_id=32976 | [
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10.15252/embj.2019103208 | Neurexins cluster Ca2+ channels within the presynaptic active zone | 2020 | Figure 1 | <sd-panel> <p><strong>Figure 1. Neurexins are not required for synapse formation at the calyx of Held</strong></p> <p>A. Diagram of the calyx of Held synapse.</p> <p>B. Strategy for selective deletion of all neurexins at the Calyx of Held by crossing PV-Cre driver mice with neurexin-1/2/3 (Nrxn123) triple conditional k... | https://api.sourcedata.io/file.php?figure_id=30150 | [
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10.15252/embj.2019103208 | Neurexins cluster Ca2+ channels within the presynaptic active zone | 2020 | Figure 2 | <sd-panel> <p><strong>Figure 2. Pan-neurexin deletion severely impairs evoked synaptic transmission at calyx synapses</strong> All experiments were carried out in acute MNTB slices from littermate control and Nrxn123 TKO mice at P12-14. EPSCs were evoked by afferent fiber stimulation and recorded in postsynaptic whole-... | https://api.sourcedata.io/file.php?figure_id=30152 | [
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10.15252/embj.2019103208 | Neurexins cluster Ca2+ channels within the presynaptic active zone | 2020 | Figure 4 | <sd-panel> <p><strong>Figure 4. Deletion of all neurexins from the calyx of Held synapse does not alter the size or properties of presynaptic Ca<sup>2+</sup>-currents</strong></p> <p>A. Example traces of presynaptic Ca<sup>2+</sup>-currents recorded in patched calyx terminals as induced by a 50 ms step depolarization f... | https://api.sourcedata.io/file.php?figure_id=30156 | [
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10.15252/embj.2019103208 | Neurexins cluster Ca2+ channels within the presynaptic active zone | 2020 | Figure 6 | <sd-panel> <p><strong>Figure 6. Pan-neurexin deletion depletes K<sup>+</sup>-currents carried by presynaptic BK-channels in the calyx of Held synapse</strong></p> <p>A. Representative traces of Ca<sup>2+</sup>-currents and 4-AP insensitive K<sup>+</sup>-currents evoked by step depolarizations (from −50 mV to +10 mV in ... | https://api.sourcedata.io/file.php?figure_id=30160 | [
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10.15252/embj.2019103208 | Neurexins cluster Ca2+ channels within the presynaptic active zone | 2020 | Figure 7 | <sd-panel> <p><strong>Figure 7. Pan-neurexin deletion depletes Ca<sub>V</sub>2.1-type Ca<sup>2+</sup>-channels and Bassoon from the presynaptic active zone of the calyx of Held</strong></p> <p>A. Representative images of brainstem cryosections stained by triple immunofluorescence labeling for vGluT1 (green), Ca<sub>V</... | https://api.sourcedata.io/file.php?figure_id=30161 | [
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22820375 | 10.1038/ncb2536 | Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy | 2012 | figf1 | <p>(<b>a</b>) Ba/F3 cells expressing myrPI(3)K-ER, myrPKB-ER, <named-entity id="named-entity-415">FOXO3</named-entity>(A3)-ER or <named-entity id="named-entity-416">FOXO4</named-entity>(A3)-ER were stimulated with <named-entity id="named-entity-417">4-OHT</named-entity> for 4 h (myrPI(3)K-ER, myrPKB-ER) or 8 h (<named-... | https://api.sourcedata.io/file.php?figure_id=3042 | [
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22820375 | 10.1038/ncb2536 | Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy | 2012 | figf2 | <p>(<b>a</b>) Ba/F3 cells expressing <named-entity id="named-entity-452">FOXO3</named-entity>(A3)-ER were stimulated with <named-entity id="named-entity-453">4-OHT</named-entity> and <named-entity id="named-entity-454">actinomycin D</named-entity> (1 μg ml<super>−1</super>) or <named-entity id="named-entity-455">dimeth... | https://api.sourcedata.io/file.php?figure_id=3043 | [
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22820375 | 10.1038/ncb2536 | Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy | 2012 | figf3 | <p>(<b>a</b>) Ba/F3 cells expressing <named-entity id="named-entity-485">FOXO3</named-entity>(A3)-ER were stimulated with <named-entity id="named-entity-486">4-OHT</named-entity> in the presence of <named-entity id="named-entity-487">mIL-3</named-entity>. Cell lysates were analysed for <named-entity id="named-entity-48... | https://api.sourcedata.io/file.php?figure_id=3044 | [
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22820375 | 10.1038/ncb2536 | Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy | 2012 | figf4 | <p>(<b>a</b>) DLD1 cells expressing <named-entity id="named-entity-508">FOXO3</named-entity>(A3)-ER were stimulated with <named-entity id="named-entity-509">4-OHT</named-entity> with or without <named-entity id="named-entity-510">MSO</named-entity>. After 24 h, the cells were starved of serum, amino acids and <named-en... | https://api.sourcedata.io/file.php?figure_id=3045 | [
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22820375 | 10.1038/ncb2536 | Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy | 2012 | figf5 | <p>(<b>a</b>) DLD1 cells expressing <named-entity id="named-entity-538">FOXO3</named-entity>(A3)-ER were stimulated with <named-entity id="named-entity-539">4-OHT</named-entity> and <named-entity id="named-entity-540">MSO</named-entity> for 24 h in <named-entity id="named-entity-541">glutamine</named-entity>-free DMEM ... | https://api.sourcedata.io/file.php?figure_id=3046 | [
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10.15252/embr.202153955 | Cardio-respiratory and phenotypicrescue of dystrophin/utrophin-deficientmice by combination therapy | 2022 | Figure 1 | <sd-panel><p><strong>Figure 1. Effects of dietary supplementation of glycine on the activity of PMO in adult <em>mdx</em> mice.</strong></p> <p><strong>PMO was administered intravenously into adult <em>mdx</em> mice at 25 or 50 mg/kg/week for 3 weeks with dietary supplementation of glycine for 3</strong> consecutive <s... | https://api.sourcedata.io/file.php?figure_id=46840 | [
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10.15252/embr.202153955 | Cardio-respiratory and phenotypicrescue of dystrophin/utrophin-deficientmice by combination therapy | 2022 | Figure 2 | <sd-panel>Figure 2. Evaluation of <sd-pretag id="sdPretag899328710sm" type="small" role="intervention">PMO</sd-pretag> supplemented with <sd-pretag id="sdPretag124802250sm" type="small" role="intervention">glycine</sd-pretag> orally in DKO <sd-pretag id="sdPretag124241746sm" type="organism" role="component">mice</sd... | https://api.sourcedata.io/file.php?figure_id=46842 | [
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10.15252/embr.202153955 | Cardio-respiratory and phenotypicrescue of dystrophin/utrophin-deficientmice by combination therapy | 2022 | Figure 3 | <sd-panel><p><strong>Figure 3. Systemic investigation of combinatorial effects of <sd-pretag id="sdPretag277530359sm" type="small" role="intervention">PMO</sd-pretag> with dietary supplementation of <sd-pretag id="sdPretag736676644sm" type="small" role="intervention">glycine</sd-pretag> and <sd-pretag id="sdPretag184... | https://api.sourcedata.io/file.php?figure_id=46844 | [
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10.15252/embr.202153955 | Cardio-respiratory and phenotypicrescue of dystrophin/utrophin-deficientmice by combination therapy | 2022 | Figure 4 | <sd-panel><p><strong>Figure 4. Long-term combinatorial effects of PMO with dietary supplementation of glycine and metformin (PMO-GM) in <em>DKO</em> mice.</strong></p> <p><strong>PMO was administered intravenously into 3-week old <em>DKO</em> mice at 50 mg/kg/week for 3 weeks with dietary supplementation of glycine for... | https://api.sourcedata.io/file.php?figure_id=46846 | [
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10.15252/embr.202153955 | Cardio-respiratory and phenotypicrescue of dystrophin/utrophin-deficientmice by combination therapy | 2022 | Figure 5 | <sd-panel><p><strong>Figure 5. Molecular correction and pathological assessment of <em>DKO</em> <sd-pretag id="sdPretag1345863681sm" type="organism" role="component">mice</sd-pretag> treated with long-term repeated administration of <sd-pretag id="sdPretag510447379sm" type="small" role="intervention">PMO</sd-pretag>-... | https://api.sourcedata.io/file.php?figure_id=46848 | [
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10.15252/embj.2019102930 | RhoJ integrates attractive and repulsive cues in directional migration of endothelial cells | 2020 | Figure 2 | <sd-panel> <p><strong>Figure 2. GTP- and GDP-RhoJ differentially associate with PlexinD1 and VEGFR2.</strong></p> <ol type="A"> <li> <p>Confocal (left three columns) and super-resolution (right-most columns) images of subcellular distributions of ectopic RhoJ (red), endogenous VEGFR2 (green) and PlexinD1 (left, white; ... | https://api.sourcedata.io/file.php?figure_id=32325 | [
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10.15252/embj.2019102930 | RhoJ integrates attractive and repulsive cues in directional migration of endothelial cells | 2020 | Figure 3 | <sd-panel> <p><strong>Figure 3. Sema3E induces EC contraction by releasing RhoJ from PlexinD1.</strong></p> <ol type="A"> <li> <p>Schematic representation of full-length PlexinD1 (PD1) and its deletion mutants.</p> </li> <li> <p>Co-IP from 293T cells 48 h after transfection. RhoJ-PlexinD1 binding was disrupted by delet... | https://api.sourcedata.io/file.php?figure_id=32327 | [
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10.15252/embj.2019102930 | RhoJ integrates attractive and repulsive cues in directional migration of endothelial cells | 2020 | Figure 4 | <sd-panel> <p><strong>Figure 4. RhoJ facilitates Sema3E-indcued reverse EC migration via activation of VEGFR2 and p38 MAPK.</strong></p> <ol type="A"> <li> <p>Co-IP from HUVECs. Blots for β-actin shown in (A) were used to confirm equal loading in (B), as the same cell lysates were analyzed in both experiments.</p> </li... | https://api.sourcedata.io/file.php?figure_id=32329 | [
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10.15252/embj.2019102930 | RhoJ integrates attractive and repulsive cues in directional migration of endothelial cells | 2020 | Figure 5 | <sd-panel> <p><strong>Figure 5. RhoJ sustains VEGF signals by preventing degradation of internalized VEGFR2.</strong></p> <ol type="A"> <li> <p>Super-resolution images of receptor colocalization in siRNA-transfected HUVECs 30 min after VEGF stimulation. VEGFR2 (green), PlexinD1 (red), and Nrp1 (white) are shown as in F... | https://api.sourcedata.io/file.php?figure_id=32331 | [
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10.15252/embj.2019102930 | RhoJ integrates attractive and repulsive cues in directional migration of endothelial cells | 2020 | Figure 6 | <sd-panel> <p><strong>Figure 6. RhoJ promotes directional EC migration in sprouting vessels.</strong></p> <ol type="A"> <li> <p>Kinetic analyses of EC migration in an <em>ex vivo</em> aortic ring angiogenesis model. Upper panels are snapshots of time-lapse imaging in which EC nuclei are labeled by SYTO dye (green). In ... | https://api.sourcedata.io/file.php?figure_id=32333 | [
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10.15252/embj.2019102930 | RhoJ integrates attractive and repulsive cues in directional migration of endothelial cells | 2020 | Figure 7 | <sd-panel> <p><strong>Figure 7. RhoJ-deficiency delays vascular development and suppresses pathological angiogenesis.</strong></p> <ol type="A"> <li> <p>Labeling for GFP (green) and CD31 (red) in retina <strong>of P4</strong> <em>Rhoj<sup>GFP/GFP</sup></em> mouse. Scale bar, 200 µm (left); 20 µm (right).</p> </li> <li>... | https://api.sourcedata.io/file.php?figure_id=32334 | [
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24013556 | 10.1038/ncomms3428 | Bit-by-bit autophagic removal of parkin-labelled mitochondria | 2013 | f3 | <p>(<b>a</b>) A HeLa cell expressing KR-dMito (red), EGFP-<named-entity id="named-entity-198">DFCP1</named-entity> (green) and EBFP2-<named-entity id="named-entity-199">parkin</named-entity> (cyan) were illuminated with 559 nm at the white dotted circle region, leading to the generation of a long <named-entity id="name... | https://api.sourcedata.io/file.php?figure_id=3345 | [
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24013556 | 10.1038/ncomms3428 | Bit-by-bit autophagic removal of parkin-labelled mitochondria | 2013 | f4 | <p>(<b>a</b>) A COS-7 cell expressing EBFP2-Ub (red), AcGFP-<named-entity id="named-entity-234">sec61β</named-entity> (green) and mcherry-<named-entity id="named-entity-235">parkin</named-entity> (cyan) was treated with 10 μM <named-entity id="named-entity-236">CCCP</named-entity> for 1 h and imaged. Impaired mitochond... | https://api.sourcedata.io/file.php?figure_id=3346 | [
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30692134 | 10.15252/embj.2018100989 | Abnormal TDP-43 function impairs activity-dependent BDNF secretion, synaptic plasticity and... | 2018 | Figure 1 | <sd-panel> <p><strong>Figure 1. <em>Tardbp</em> knockdown induces production of a soluble form of Sortilin that impairs BDNF sorting to the regulated pathway and activity-dependent secretion in mouse hippocampal neurons</strong></p> <ol type="A"> <li> <p>Expression of <em>Tardbp</em>, total <em>Sort1</em> and exon 17b ... | https://api.sourcedata.io/file.php?figure_id=24487 | [
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30692134 | 10.15252/embj.2018100989 | Abnormal TDP-43 function impairs activity-dependent BDNF secretion, synaptic plasticity and... | 2018 | Figure 2 | <sd-panel> <p><strong>Figure 2. CA1-specific knockout of TDP-43 increases levels of exon 17b <em>Sort1</em> mRNA and soluble Sortilin protein</strong></p> <ol type="A"> <li> <p>Representative photomicrographs of TDP-43 (green) and NeuN (red) immunohistochemistry in hippocampal CA1 of <em>Tardbp</em><sup>fx/fx</sup> and... | https://api.sourcedata.io/file.php?figure_id=24488 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "230908",
"ext_tax_ids": "10090",
"ext_tax_names": "Mus musculus",
"mapping_source": "ncbi_gene",
"mapping_status": "mapped",
"ncbi_gene_id": "230908",
"original_type": "gene",
"role": "intervention",
"text": "Tardbp",
"type": "genepro... | |
30692134 | 10.15252/embj.2018100989 | Abnormal TDP-43 function impairs activity-dependent BDNF secretion, synaptic plasticity and... | 2018 | Figure 3 | <sd-panel> <p><strong>Figure 3. CA1-specific knockout of TDP-43 reduces dendrite complexity and spine number through altered Sortilin splicing</strong></p> <ol type="A"> <li> <p>Representative photomicrograph of Golgi staining in hippocampus of a <em>Tardbp</em><sup>fx/fx</sup> mouse.</p> </li> <li> <p>Sholl analysis o... | https://api.sourcedata.io/file.php?figure_id=24489 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "230908",
"ext_tax_ids": "10090",
"ext_tax_names": "Mus musculus",
"mapping_source": "ncbi_gene",
"mapping_status": "mapped",
"ncbi_gene_id": "230908",
"original_type": "gene",
"role": "intervention",
"text": "Tardbp",
"type": "genepro... | |
30692134 | 10.15252/embj.2018100989 | Abnormal TDP-43 function impairs activity-dependent BDNF secretion, synaptic plasticity and... | 2018 | Figure 4 | <sd-panel> <p><strong>Figure 4. CA1-specific knockout of TDP-43 impairs spatial memory and abolishes BDNF-dependent TBS-LTP through altered Sortilin splicing</strong></p> <ol type="A"> <li> <p>Percentage of change in field excitatory postsynaptic potential (fEPSP) recorded from hippocampal area CA1 after theta-burst st... | https://api.sourcedata.io/file.php?figure_id=24490 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "230908",
"ext_tax_ids": "10090",
"ext_tax_names": "Mus musculus",
"mapping_source": "ncbi_gene",
"mapping_status": "mapped",
"ncbi_gene_id": "230908",
"original_type": "gene",
"role": "intervention",
"text": "Tardbp",
"type": "genepro... | |
30692134 | 10.15252/embj.2018100989 | Abnormal TDP-43 function impairs activity-dependent BDNF secretion, synaptic plasticity and... | 2018 | Figure 5 | <sd-panel> <p><strong>Figure 5. Aggregation of TDP-43 impairs activity-dependent BDNF secretion through altered Sortilin splicing</strong></p> <ol type="A"> <li> <p>Representative photomicrographs of cultured hippocampal neurons immunostained for TDP-43 (green), FLAG (red) and counterstained with DAPI (blue) in control... | https://api.sourcedata.io/file.php?figure_id=24491 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "23435",
"ext_tax_ids": "9606",
"ext_tax_names": "Homo sapiens",
"mapping_source": "ncbi_gene",
"mapping_status": "mapped",
"ncbi_gene_id": "23435",
"original_type": "gene",
"role": "intervention",
"text": "TDP-43",
"type": "geneprod",... | |
30692134 | 10.15252/embj.2018100989 | Abnormal TDP-43 function impairs activity-dependent BDNF secretion, synaptic plasticity and... | 2018 | Figure 6 | <sd-panel> <p><strong>Figure 6. Disease-associated mutations in TDP-43 increase levels of exon 17b <em>Sort1</em> mRNA and impair activity-dependent BDNF secretion in mouse hippocampal neurons and patient-derived human neurons</strong></p> <ol type="A"> <li> <p>Expression of <em>Tardbp</em> (left), total <em>Sort1</em>... | https://api.sourcedata.io/file.php?figure_id=24492 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "20661",
"ext_tax_ids": "10090",
"ext_tax_names": "Mus musculus",
"mapping_source": "ncbi_gene",
"mapping_status": "mapped",
"ncbi_gene_id": "20661",
"original_type": "gene",
"role": "assayed",
"text": "Sort1",
"type": "geneprod",
... | |
29101300 | 10.15252/msb.20177701 | Pharmacoproteomic characterisation of human colon and rectal cancer | 2017 | Figure 4 | <p><strong>Figure 4 - MAP2K1 is a predictive marker for inhibitors targeting EGFR</strong></p>
<p>Effect-size heat maps of six drugs (see titles of panels) targeting EGFR. It is evident that the different drugs showed different profiles but also that high MAP2K1 expression (blue/red gradient across cell lines) was cons... | https://api.sourcedata.io/file.php?figure_id=16217 | [
{
"ext_dbs": "Uniprot",
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"ext_tax_ids": "9606",
"ext_tax_names": "Homo sapiens",
"mapping_source": "direct",
"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "assayed",
"text": "MAP2K1",
"type": "geneprod",
"uni... | |
29101300 | 10.15252/msb.20177701 | Pharmacoproteomic characterisation of human colon and rectal cancer | 2017 | Figure 5 | <p><strong>Figure 5 - MERTK is a predictive marker for inhibitors targeting MEK1/2 in CRC cell lines</strong></p>
<p>(A) Effect-size heat maps of two drugs (one from two different drug sensitivity screens) targeting MEK1/2 show consistent association of high MERTK expression with drug resistance. The colour scheme is t... | https://api.sourcedata.io/file.php?figure_id=16218 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "Q12866",
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"ext_tax_names": "Homo sapiens",
"mapping_source": "direct",
"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "assayed",
"text": "MERTK",
"type": "geneprod",
"unip... | |
29101300 | 10.15252/msb.20177701 | Pharmacoproteomic characterisation of human colon and rectal cancer | 2017 | Figure 6 | <p><strong>Figure 6 - MERTK is a prognostic marker in CRC patients</strong></p>
<p>(A) Western Blot visualising MERTK expression in two negative (RKO, CC07) and two positive control cell lines (CaCo-2; HT55).</p>
<p>(B) IHC staining of MERTK expression in RKO (negative control) and CaCo-2 (positive control) cells.</p>
... | https://api.sourcedata.io/file.php?figure_id=16219 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "Q12866",
"ext_tax_ids": "9606",
"ext_tax_names": "Homo sapiens",
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"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "assayed",
"text": "MERTK",
"type": "geneprod",
"unip... | |
10.15252/embr.201948901 | TMEM135 regulates primary ciliogenesis through modulation of intracellular cholesterol distribution | 2020 | Figure 1 | <sd-panel> <p><strong>Figure 1. Depletion of TMEM135 results in cholesterol accumulation in lysosomes.</strong></p> <p><strong>(A)</strong> RPE1 cells were transfected with either scramble or TMEM135 siRNAs and immunostained for LAMP1 as a lysosome marker (red) and PMP70 as a peroxisome marker (green). Scale bar, 10 μm... | https://api.sourcedata.io/file.php?figure_id=30839 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "65084",
"ext_tax_ids": "9606",
"ext_tax_names": "Homo sapiens",
"mapping_source": "ncbi_gene",
"mapping_status": "mapped",
"ncbi_gene_id": "65084",
"original_type": "gene",
"role": "intervention",
"text": "TMEM135",
"type": "geneprod"... | ||
10.15252/embr.201948901 | TMEM135 regulates primary ciliogenesis through modulation of intracellular cholesterol distribution | 2020 | Figure 2 | <sd-panel> <p><strong>Figure 2. Depletion of TMEM135 impairs ciliogenesis through disruption of intracellular cholesterol distribution.</strong></p> <p><strong>(A)</strong> RPE1 cells were transfected with siRNAs as indicated, followed by serum starvation for 24 h, and immunostained for ARL13B (red) and γ-tubulin (gree... | https://api.sourcedata.io/file.php?figure_id=30841 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "Q3SXY8",
"ext_tax_ids": "9606",
"ext_tax_names": "Homo sapiens",
"mapping_source": "direct",
"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "assayed",
"text": "ARL13B",
"type": "geneprod",
"uni... | ||
10.15252/embr.201948901 | TMEM135 regulates primary ciliogenesis through modulation of intracellular cholesterol distribution | 2020 | Figure 3 | <sd-panel> <p><strong>Figure 3. Depletion of TMEM135 impairs both trafficking and enhanced IFT20 recruitment to centrioles.</strong></p> <p><strong>(A)</strong> RPE1 cells were transfected with siRNA as indicated, and immunostained for Rab8 (red) and γ-tubulin (green) in either 10% FBS medium (upper panel) or serum-sta... | https://api.sourcedata.io/file.php?figure_id=30843 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "P61006",
"ext_tax_ids": "9606",
"ext_tax_names": "Homo sapiens",
"mapping_source": "direct",
"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "assayed",
"text": "Rab8",
"type": "geneprod",
"unipr... | ||
10.15252/embr.201948901 | TMEM135 regulates primary ciliogenesis through modulation of intracellular cholesterol distribution | 2020 | Figure 4 | <sd-panel> <p><strong>Figure 4. Ectopic expression of a constitutively active form of Rab8 recovers ciliogenesis in TMEM135-depleted cells.</strong></p> <p><strong>(A)</strong> RPE1 cells were transfected with siRNAs as indicated, followed by transfection with wild-type pGFP-Rab8a (WT-Rab8), constitutively active pGFP-... | https://api.sourcedata.io/file.php?figure_id=30845 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "4218",
"ext_tax_ids": "9606",
"ext_tax_names": "Homo sapiens",
"mapping_source": "ncbi_gene",
"mapping_status": "mapped",
"ncbi_gene_id": "4218",
"original_type": "gene",
"role": "intervention",
"text": "Rab8",
"type": "geneprod",
... | ||
10.15252/embr.201948901 | TMEM135 regulates primary ciliogenesis through modulation of intracellular cholesterol distribution | 2020 | Figure 5 | <sd-panel> <p><strong>Figure 5. Malfunctioned ciliogenesis observed during TMEM135 depletion is not associated with IFT20.</strong></p> <p><strong>(A)</strong> RPE1 cells were transfected with siRNAs as indicated, followed by 24 h incubation in serum-starved media. Cells were then and subjected to fractionation, and We... | https://api.sourcedata.io/file.php?figure_id=30847 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "Q8IY31",
"ext_tax_ids": "9606",
"ext_tax_names": "Homo sapiens",
"mapping_source": "direct",
"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "assayed",
"text": "IFT20",
"type": "geneprod",
"unip... | ||
10.15252/embr.201948901 | TMEM135 regulates primary ciliogenesis through modulation of intracellular cholesterol distribution | 2020 | Figure 6 | <sd-panel> <p><strong>Figure 6. Enhanced IFT20 intensity induced by serum starvation at centrioles depends on Rab8 activation.</strong></p> <p><strong>(A)</strong> Efficiency of Rab8a depletion confirmed by Western blot in RPE1 cells.</p> <p><strong>(B)</strong> RPE1 cells were transfected by siRNAs as indicated, follo... | https://api.sourcedata.io/file.php?figure_id=30849 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "4218",
"ext_tax_ids": "9606",
"ext_tax_names": "Homo sapiens",
"mapping_source": "ncbi_gene",
"mapping_status": "mapped",
"ncbi_gene_id": "4218",
"original_type": "gene",
"role": "intervention",
"text": "Rab8a",
"type": "geneprod",
... | ||
10.15252/embr.201948901 | TMEM135 regulates primary ciliogenesis through modulation of intracellular cholesterol distribution | 2020 | Figure 7 | <sd-panel> <p><strong>Figure 7. Cholesterol-MβCD complex rescues impaired Rab8 trafficking to the centriole, augments Rab8-GTP binding, and increases IFT20 intensity at the centriole in TMEM135-depleted cells.</strong></p> <p><strong>(A)</strong> RPE1 cells were transfected as indicated, followed by incubation in serum... | https://api.sourcedata.io/file.php?figure_id=30850 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "P61006",
"ext_tax_ids": "9606",
"ext_tax_names": "Homo sapiens",
"mapping_source": "direct",
"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "assayed",
"text": "Rab8",
"type": "geneprod",
"unipr... | ||
10.15252/embj.2020107257 | The Arabidopsis E3 ubiquitin ligase PUB4 regulates BIK1 and is targeted by a bacterial type-III effector | 2022 | Figure 1 | <p><strong>Figure 1. RipAC inhibits PTI in Arabidopsis</strong></p><p>(A-C) RipAC overexpression inhibits ROS production induced by 50 nM flg22<sup>Pto</sup> (A), 100 nM elf18<sup>Rsol</sup> (B), and 200 μg/mL chitin (C) in Arabidopsis. ROS was measured as relative luminescence units (RLU) over time. Values are means ±... | https://api.sourcedata.io/file.php?figure_id=50308 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "2831203",
"ext_tax_ids": "267608",
"ext_tax_names": "Ralstonia solanacearum GMI1000",
"mapping_source": "unmapped",
"mapping_status": "unmapped",
"ncbi_gene_id": "2831203",
"original_type": "gene",
"role": "intervention",
"text": "RipAC",... | ||
10.15252/embj.2020107257 | The Arabidopsis E3 ubiquitin ligase PUB4 regulates BIK1 and is targeted by a bacterial type-III effector | 2022 | Figure 2 | <p><strong>Figure 2 RipAC associates with PUB4 in plant cells</strong></p><p>(A-B) Interaction between RipAC and SlPUB4/AtPUB4 was confirmed by Split-LUC assay qualitatively (A) and quantitatively (B) in <em>Nicotiana benthamiana</em>. Values are means ± SE (n=8 biological replicates). Asterisks indicate significant di... | https://api.sourcedata.io/file.php?figure_id=50309 | [
{
"ext_dbs": "Uniprot",
"ext_ids": "K4D648",
"ext_tax_ids": "4081",
"ext_tax_names": "Solanum lycopersicum",
"mapping_source": "direct",
"mapping_status": "mapped",
"ncbi_gene_id": null,
"original_type": "protein",
"role": "assayed",
"text": "PUB4",
"type": "geneprod",
... | ||
10.15252/embj.2020107257 | The Arabidopsis E3 ubiquitin ligase PUB4 regulates BIK1 and is targeted by a bacterial type-III effector | 2022 | Figure 3 | <p><strong>Figure 3. PUB4 positively regulates PTI in Arabidopsis</strong></p><p>(A-D) ROS burst in Col-0 WT or the indicated <em>pub4</em> mutant lines induced by 100 nM flg22<sup>Paer</sup> (A), 100 nM elf18<sup>Ecol</sup> (B), 1 μM AtPep1 (C) and 1 mg/mL chitin (D). ROS was measured as relative luminescence units (R... | https://api.sourcedata.io/file.php?figure_id=50310 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "816846",
"ext_tax_ids": "3702",
"ext_tax_names": "Arabidopsis thaliana",
"mapping_source": "ncbi_gene",
"mapping_status": "mapped",
"ncbi_gene_id": "816846",
"original_type": "gene",
"role": "intervention",
"text": "pub4",
"type": "ge... | ||
10.15252/embj.2020107257 | The Arabidopsis E3 ubiquitin ligase PUB4 regulates BIK1 and is targeted by a bacterial type-III effector | 2022 | Figure 5 | <p><strong>Figure 5. PUB4 associates with PRR complexes</strong></p><p><strong>(A) PUB4 associates in <em>Arabidopsis</em> with EFR, BAK1, and SERK2 after 1</strong> μM <strong>elf18</strong><sup>Ecol</sup> <strong>treatment, and constitutively with XLG2 and XLG1. PRR complex members were identified after immunoprecipi... | https://api.sourcedata.io/file.php?figure_id=50312 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "816846",
"ext_tax_ids": "3702",
"ext_tax_names": "Arabidopsis thaliana",
"mapping_source": "ncbi_gene",
"mapping_status": "mapped",
"ncbi_gene_id": "816846",
"original_type": "gene",
"role": "intervention",
"text": "PUB4",
"type": "ge... | ||
10.15252/embj.2020107257 | The Arabidopsis E3 ubiquitin ligase PUB4 regulates BIK1 and is targeted by a bacterial type-III effector | 2022 | Figure 6 | <p><strong>Figure 6. RipAC does not affect PUB4 association with PRRs and BIK1.</strong></p><p>RipAC does not affect PUB4 association with PRR complex members. <em>PUB4-FLAG, PUB4-FLAG RipAC-GFP</em> and Col-0 plants were treated for 10 min with water (as mock) or 1 μM flg22<sup>Paer</sup> and elf18<sup>Ecol</sup> trea... | https://api.sourcedata.io/file.php?figure_id=50313 | [
{
"ext_dbs": "NCBI gene",
"ext_ids": "2831203",
"ext_tax_ids": "267608",
"ext_tax_names": "Ralstonia solanacearum GMI1000",
"mapping_source": "unmapped",
"mapping_status": "unmapped",
"ncbi_gene_id": "2831203",
"original_type": "gene",
"role": "intervention",
"text": "RipAC",... |
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