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Attack kills 12 in Afghanistan | NATO: 3 troops killed in Afghanistan attack | 2.4 |
Food poisoning kills at least 20 children in India | Baghdad cafe bombing kills at least 38 | 0 |
Zoo worker dies after tiger attack | Indian-origin teacher dies after attack in New Zealand | 0.4 |
Six killed in drone strike in N Waziristan | 12 killed in bus accident in Pakistan | 1.8 |
17 govt employees killed in Pakistan bus bombing | At least 78 killed in Pakistan church bombing | 0.8 |
At least 12 dead in Washington ... | At least 150 dead as strong quake hits southwest Balochistan | 0.4 |
Israel 'bombs' Syria as envoy presses peace talks bid | Fierce clashes in east Syria as US pushes peace talks | 2.2 |
US, Russia enter third day of Syria talks | US and Russia agree Syria arms deal in Geneva | 1.8 |
Australia cuts rates to record low | Australia cuts interest rates to record low | 4.6 |
Syria opposition unity take face specter of collapse | Syria divided opposition struggles within wider Syrian struggle | 2.2 |
International forensic teams join Kenyan mall carnage probe | Arrested Briton 'not significant' to Kenya attack probe | 1 |
Obama signs law aimed at barring Iran UN envoy | Obama urges no new sanctions on Iran | 1 |
Fire in Russian psychiatric hospital kills 38 | 38 feared dead in Russian psychiatric hospital fire | 4.2 |
DPRK leader calls for better ties with S.Korea | North Korea urges foreigners to leave South Korea | 0.4 |
Chinese, Russian FMs exchange opinions on Ukraine crisis | Chinese president arrives in Argentina for state visit | 0.2 |
Poll: Cory Booker takes early lead for N.J. Senate | Nigella Lawson 'took cocaine every day for a decade' | 0 |
Blast on Indian train kills one | State: No funds for yeshiva that incites violence | 0 |
Iran threatens to trigger oil price war | Man admits threatening to kill Prince Harry | 0 |
Manchester United Ticket Sales And Profit Down | Manchester United owner Malcolm Glazer dies at 85 | 0.6 |
Foreign companies eye new 'opening-up' | More carriers likely in China | 0.6 |
U.S. fast-food workers plan nationwide strikes over minimum wage | Fast-food workers strike for higher pay | 4 |
All eyes on new Pak army chief Raheel Sharif | Flood alerts in France as river levels rise | 0 |
One killed, 40 injured in Mexico candy factory blast | Three killed, 21 injured in two road mishaps | 0.8 |
Hassoun to Mauritanian delegation: conspiracy imposed on Syria targets its stances, particularly over Palestine | Mufti : conspiracy aginst Syria targets its stances, particularly towards Palestine | 3.2 |
Hong Kong set for democracy march | Hong Kong set for huge democracy rally | 4.8 |
Senate confirms Janet Yellen as chair of US Federal Reserve | US Senate Confirms Janet Yellen as New Central Bank Chief | 4.2 |
Obama to meet with China’s Xi in California June 7-8 | Obama to meet Ukrainian prime minister at White House | 2.2 |
Protests for kidnapped girls banned in Nigerian capital | Scores 'killed' in Boko Haram raid in Nigeria | 1 |
China yuan weakens to 6.1559 against USD | China yuan weakens to 6.1818 against USD Tuesday | 3.6 |
Israelis and Palestinians aim to negotiate a 'final' peace deal after positive talks | Israeli army kills 3 Palestinian militants in West Bank clashes | 1.6 |
Japanese politician apologizes for sex comment | Japan mayor apologizes to U.S., denies wrong words on "comfort women" | 3 |
4 killed, 6 injured in attacks in Iraq | 43 killed, 86 wounded in attacks in Iraq | 2.4 |
Iran backs proposal for meeting on Syria conflict | Iran says Israel lying about rockets | 0.4 |
Thai government says elections Feb. 2 | Philippines government says peace talks with communists have failed | 0 |
Colorado Governor Visits School Shooting Victim | Colorado governor visits school shooting victim | 5 |
Pakistani Taliban chief Hakimullah Mehsud killed in drone strike | Pakistani Taliban 'elect new chief', vow 'unprecedented' revenge | 1.2 |
House blaze kills 7 in northern Pakistan | US drone strike kills 8 in NW Pakistan | 1.4 |
FAA lifts ban on U.S. flights to Tel Aviv | FAA lifts ban on U.S. flights to Israel | 4 |
World's oldest man dies at 116 | Japan: World's Oldest Man Ever Dies Aged 116 | 4.6 |
Pakistanis vote in landmark election | Pakistan holds landmark election as 29 killed in attacks | 3.4 |
Algeria president gets therapy after stroke: state media | Bulgarian president tries to break election stalemate | 0.4 |
Yemen: Fighting in north kills over 120 | Janet Yellen: Five things you might not know | 0 |
Pakistan's Musharraf charged over Bhutto murder | Pakistan's Musharraf Charged In Bhutto Death | 4.8 |
US Supreme Court limits president's recess appointments power | High court checks President's recess appointment power | 5 |
Euro crisis is over, says France's Francois Hollande | Eurozone debt crisis is over, says France's President | 4 |
Treasury proposal sees 1.5% increase in income tax | Treasury proposes 1.5% income tax raise in budget | 4 |
EU Ministers of Employment and Social policy will discuss how to boost employment, integrate social and economic policies | EU Ministers of Employment and Social policy to discuss employment boosting strategies | 3 |
Chinese lunar rover lands on moon | China lands robot rover on moon | 5 |
Boy, 14, arrested for sex attacks around a university campus | Two teenagers arrested after string of sex attacks on Manchester University campus | 2 |
Protests after George Zimmerman acquitted in Trayvon Martin case | Zimmerman acquitted in slaying | 3 |
Maldives begins to vote in controversy-ridden presidential poll | Crisis-hit Maldives holds new presidential poll | 3 |
Obama, Hollande Hail Transformed US-French Relationship | Hollande arrives for US state visit | 1 |
Iran, IAEA Officials Meet Ahead of March Nuclear Deadline | Iran, IAEA officials meet ahead of March nuclear deadline: ISNA | 5 |
Bombings kill 9 people in Iraqi capital | Bombings kill 19 people in Iraq | 2 |
10 Things to Know for Wednesday | 10 Things to Know for Thursday | 2 |
New UN peacekeeping chief named for Central African Republic | UN takes over peacekeeping in Central African Republic | 2 |
Oil falls in Asian trade | Oil prices down in Asian trade | 5 |
Israeli forces detain Palestinian MP in Hebron | Israeli forces detain 2 Palestinians in overnight arrest raids | 3 |
Israeli police clash with Palestinian protesters at sensitive Jerusalem holy site | Israel Police Clash With Palestinians in Jerusalem | 3 |
3 killed, 4 injured in Los Angeles shootings | Five killed in Saudi Arabia shooting | 0 |
Scientists prove there is water on Mars | Has Nasa discovered water on Mars? | 2 |
Pranab stresses need to strive for peace by nations | WTO: India regrets action of developed nations | 0 |
Volkswagen skids into red in wake of pollution scandal | Volkswagen's "gesture of goodwill" to diesel owners | 2 |
Obama is right: Africa deserves better leadership | Obama waiting for midterm to name attorney general | 0 |
New video shows US police officers beating mentally-ill man | New York police officer critically wounded in hatchet attack | 0 |
It has recently been shown that Craf is essential for Kras G12D-induced NSCLC. | It has recently become evident that Craf is essential for the onset of Kras-driven non-small cell lung cancer. | 4 |
The Bcl-2 inhibitor ABT-737 induces regression of solid tumors and its derivatives are in the early clinical phase as cancer therapeutics; however, it targets Bcl-2, Bcl-XL, and Bcl-w, but not Mcl-1, which induces resistance against apoptotic cell death triggered by ABT-737. | Recently, it has been reported that ABT-737 is not cytotoxic to all tumors cells, and that chemoresistance to ABT-737 is dependent on appreciable levels of Mcl-1 expression, the one Bcl-2 family member it does not effectively inhibit. | 3 |
Previous studies demonstrated that the decrease level of 5 hmC in tumors was due to the reduced expression of TET1/2/3 and IDH2 genes or tumor derived IDH1 and IDH2 mutations. | In addition, genetic and functional studies suggest that neomorphic IDH mutations contribute to myeloid transformation, at least in part, by inhibiting TET enzymatic function. | 2.2 |
More recently, IDH mutations and resultant 2-hydroxyglutarate (2HG) production in leukemia cells were reported to induce global DNA hypermethylation through impaired TET2 catalytic function. | It has also been recently reported that mutations of the isocitrate dehydrogenase genes IDH1 and IDH2 can lead to the aberrant production of 2-hydroxyglutarate (2-HG), a metabolite that inhibits TET2 enzymatic activity, resulting in a hypermethylated promoter phenotype in acute myeloid leukemia (AML) tumors carrying ID... | 3.2 |
Recent in vitro studies using shRNA-based approaches have suggested a role for TET2 in regulating myeloid differentiation and in regulating stem/progenitor cell proliferation. | Two recent studies used RNAi-mediated Tet2 knock-down in vitro to suggest that TET2 depletion led to impaired hematopoietic differentiation and to preferential myeloid commitment. | 3.2 |
Recently, it was reported that expression of IDH1R132H suppresses TET2 activity and the mutations of IDH1 and IDH2 genes occur in a mutual exclusive manner with that of TET2 gene in AML. | This large-scale study showed that IDH1/IDH2 mutations were mutually exclusive with inactivating TET2 mutations, suggesting that the two types of mutations had similar effects and were thus functionally redundant. | 3.2 |
Recently, it was reported that expression of IDH1R132H suppresses TET2 activity and the mutations of IDH1 and IDH2 genes occur in a mutual exclusive manner with that of TET2 gene in AML | The mechanism was clarified by yet another genomic survey, this time involving acute myelogenous leukemia (AML). | 1.4 |
expression of an activated form of Ras proteins can induce senescence in some primary fibroblasts. | When expressed alone in primary cells however, oncogenic Ras induces premature senescence, a putative tumour suppressor mechanism to protect from uncontrolled proliferation. | 3 |
A high percentage of tumor cells that take on immortalized characteristics show telomerase activity and it has been suggested that hTERT expression may be one of the six key events common to cancer. | As a serine/threonine protein kinase, AKT functions by phosphorylating key intermediate signaling molecules, leading to increased cell metabolism, cell growth, cell survival, and cell invasiveness—all hallmarks of cancer. | 1.4 |
In view of the evidence that many tumors occurring in nature arise from the selection of cells with genetic and/or epigenetic changes. | The phenomena of neoplastic development and neoplastic transformation, whether they occur in vivo or in vitro, are thought to represent the accumulation of a series of genetic and epigenetic alterations that disrupt the normal processes of cell division and tissue integrity. | 3 |
The phenomena of neoplastic development and neoplastic transformation, whether they occur in vivo or in vitro, are thought to represent the accumulation of a series of genetic and epigenetic alterations that disrupt the normal processes of cell division and tissue integrity. | Neoplastic development represents cumulative genetic and epigenetic events leading to the emergence of cells that can attain a tumorigenic phenotype. | 3 |
Tumorigenesis is a multistage process that involves multiple cell types. | Previous studies have suggested a number of hallmark functions that need to be acquired for a cancer to generate, helping researchers understand the complexity in tumor progression in a way of logical, scientific manner. | 1 |
Furthermore, transiently expressed exogenous LATS2 is localized to centrosomes. | LATS1 and LATS2 have been detected on interphase and mitotic centrosomes | 3 |
Since in S. cerevisiae DBF2 was shown to be associated with anaphase and/or telophase progression, we examined whether the deletion of the kinase would also affect cell cycle progression in N. crassa | Taking into consideration the role that DBF2 homologs have been shown to play in cell cycle progression, predominant localization of DBF-2 in N.crassa is expected. | 2 |
Several computational target prediction approaches, such as TargetScan, PicTar, miRanda, PITA, DIANA-microT and RNAhybrid, have been developed to predict target genes. | Three programs, PicTar, miRanda, and TargetScan , were used to predict the targets of miR-21. | 2.4 |
Several lines of evidence suggest that the known principal RB pathway lesions in human tumors act in a mutual exclusive manner. | In individual human tumor specimens, these principal components of the pathway—RB-CDK4/6-p16INK4A—are reported to be targeted in a mutually exclusive manner. | 3.4 |
The Retinoblastoma protein, pRb, was among the first recognized tumor suppressor proteins, and loss or repression of pRb function is thought to play a causative role in most human cancers. | Mutation of the retinoblastoma tumor susceptibility gene (RB1) is the rate-limiting step in the genesis of retinoblastoma and over 90% of human tumors exhibit reduced pRB function. | 3 |
For example, loss of, or functional alterations in, the two major tumor suppressor proteins pRB and p53 cause an up-regulation of ribosome biogenesis in cancer tissues. | E2F1 stabilizes p53 by inducing the expression of p19(p14)/ARF, an inhibitor of the mdm2 ubiquitin ligase that targets p53 for proteolysis. | 2 |
Recently, miR-126 was identified as a metastasis suppressing miRNA that is downregulated in relapsing breast cancer, leukemia, and cervical cancer. | Subsequent reports showed that miR-126 targeted the oncogene IRS-1 (insulin receptor substrate-1) in breast cancer cells and miR-126 was downregulated in cervical cancer. | 3.2 |
Recently, miR-126 was identified as a metastasis suppressing miRNA that is downregulated in relapsing breast cancer, leukemia, and cervical cancer. | MiR-155 is upregulated in several human tumors, such as chronic lymphocytic leukemia, melanoma, head and neck squamous cell carcinoma, clear-cell kidney cancer , hepatocellular carcinoma, lymphoma, thyroid carcinoma], breast cancer, colon cancer, cervical cancer, pancreatic cancer, and lung cancer. | 2 |
Up-regulation of miR-24 has been observed in a number of cancers, including OSCC. | In addition, miR-24 is one of the most abundant miRNAs in cervical cancer cells, and is reportedly up-regulated in solid stomach cancers. | 3 |
MiR-223 seems to be a target molecule of TFs regulating granulopoiesis. | Feedback loops in which a miRNA-regulated transcription factor regulates the transcription of its cognate miRNA have been described in a number of animals. | 1.2 |
Furthermore, a very recent study demonstrated the mechanism that specifies myeloid expression of miR-223 and proposed a unique “minicircuitry” comprised of miR-223 and transcription factors, NFI-A and CAAT enhancer-binding protein α (C/EBPα) | miR-223 regulates granulopoiesis by a feedback mechanism and is modulated competitively by the transcription factors nuclear factor I/A (NFI-A) and CCAAT/enhancer binding protein-α (C/EBPα). | 3.4 |
miR-223 regulates granulopoiesis by a feedback mechanism and is modulated competitively by the transcription factors nuclear factor I/A (NFI-A) and CCAAT/enhancer binding protein-α (C/EBPα) | There is growing evidence from animal systems that miRNA-regulated transcription factors frequently regulate the transcription of their cognate miRNAs. | 1.8 |
In myelopoiesis, miR-223 has been shown to regulate granulocyte development in both humans and mice. | As shown previously, miR-223 is highly conserved, and its myeloid-specific expression is also well characterized in both human and mouse | 3.6 |
To clarify the roles of miRNAs in erythropoiesis, four miRNAs were selected (miR-155, miR-221, miR-223, and miR-451) because their expression seems to be relevant to hematopoiesis. | In myelopoiesis, miR-223 has been shown to regulate granulocyte development in both humans and mice. | 2 |
We then sought to reassess the regulation of miR-223 in the exactly same experimental system adopted in the previous work | Importantly, our reassessment revealed that this conserved promoter is probably active in the induction of miR-223 during All-trans retinoic acid (ATRA)-induced differentiation of the APL cell line, NB4 cells, which is the main experimental system adopted in the previous study | 2.4 |
Unique segments of homologous sequences in RIP1 and RIP3 (RIP homotypic interaction motifs, RHIMs) were shown to mediate their interaction | RIP1 was reported to interact with RIP3. | 3.4 |
This form of necrosis, also termed necroptosis, requires the activity of receptor-interacting protein kinase 1 (RIP1) and its related kinase, RIP3 | TNF-mediated programmed necrosis typically involves the receptor-interacting serine-threonine kinases 1 and 3 (RIP1 and RIP3), as evidenced in human, mouse, and zebrafish cell lines, as well as in a murine sepsis model | 3 |
This form of necrosis, also termed necroptosis, requires the activity of receptor-interacting protein kinase 1 (RIP1) and its related kinase, RIP3 | Moreover, other reports have also shown that necroptosis could be induced via modulating RIP1 and RIP3. | 4 |
Furthermore, ablation of both Erk1 and Erk2 impaired tumor development, whereas inactivation of either one alone had no effect. | Only concomitant ablation of ERK1 and ERK2 impairs tumor growth. | 4 |
Importantly, the role of ERK phosphorylation in Kras-driven NSCLCs has been recently highlighted by the demonstration that ERK activity is essential for Kras-driven lung tumorigenesis. | As mentioned above, high ERK activity is crucial for the development of Kras-driven NSCLCs. | 3.4 |
Lung tumour formation in mice by oncogenic KRAS requires CRaf, but not BRaf. | The oncogenic activity of mutant Kras appears dependent on functional Craf but not on Braf. | 3.4 |
The oncogenic activity of mutant Kras appears dependent on functional Craf, but not on Braf | Notably, c-Raf has recently been found essential for development of K-Ras-driven NSCLCs | 3 |
The oncogenic activity of mutant Kras appears dependent on functional Craf. | Oncogenic KRAS mutations are common in cancer. | 2 |
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