Split (1)

train · 262k rows

text stringlengths 253 685k
Umberto Eco, the renowned Italian novelist, philosopher and semiotician, captures the essence of imagination and intellect in his works. With his vast knowledge spanning an array of subjects, from medieval studies to literary theory, Eco's insights delve into the complex realms of history, culture and art. His profound understanding of symbols, signs and the human mind has paved the way for groundbreaking contributions to academic fields and has left an indelible mark on literature. Today, I have the privilege of sitting down to interview this extraordinary figure, peering into the mind of a man who has shaped our perception of the world and its intricacies. With his gentle demeanor and intellect radiating from him, Umberto Eco possesses a captivating presence that leaves one eagerly anticipating the treasures hidden within his words. As we embark on this insightful conversation, we aim to uncover the inspirations that have driven Eco's impressive career, his thoughts on the interplay between fiction and reality, and the profound insights he has unearthed through his academic work. Umberto Eco's creative brilliance and profound understanding of the human condition have made him a literary luminary of our time, and I eagerly anticipate the enlightening discourse that lies ahead. Umberto Eco (1932-2016) was an Italian author, philosopher, and literary critic renowned for his deep understanding and exploration of various subjects, including semiotics, aesthetics, medieval history, and popular culture. Born in the small town of Alessandria, Italy, Eco's diverse academic background and keen intellect enabled him to seamlessly merge different fields of study in his writing, resulting in a unique and thought-provoking body of work. With his exceptional ability to engage readers with complex ideas through his rich storytelling, Eco became an internationally acclaimed author, best known for his novels, including "The Name of the Rose" and "Foucault's Pendulum." Throughout his career, Eco transcended traditional boundaries, becoming a leading figure in both the academic and literary worlds, revered for his incredible intellect, creativity, and extensive knowledge. 10 Thought-Provoking Questions with Umberto Eco 1. Can you provide ten On Ugliness by Umberto Eco quotes to our readers? 1. "Ugliness is not an inherent quality; it is a product of our perception." 2. "Beauty may capture our attention, but ugliness captivates our curiosity." 3. "Ugliness, in its defiance of conventional standards, can have a subversive power." 4. "Ugliness lives in the shadows, waiting to be discovered by those who dare to see beyond appearances." 5. "Ugliness is a reminder that the world is not always harmonious and perfect, but wonderfully imperfect." 6. "Sometimes, ugliness reveals the hidden aspects of our own soul, forcing us to confront our deepest fears." 7. "Ugliness challenges our notions of aesthetics, forcing us to question what is truly beautiful." 8. Ugliness can illuminate the underlying truths that lie beneath the surface of our carefully constructed reality. 9. "Ugliness, much like beauty, is in the eye of the beholder." 10. Ugliness reminds us that perfection is not the pinnacle of existence, but rather a journey towards acceptance. In my book "On Ugliness," I was driven to explore the concept of ugliness throughout history and its influence on various facets of human existence. The inspiration behind delving into this topic arose from my conviction that beauty and ugliness are intertwined in a complex relationship, shaping art, culture, and society. By examining how ugliness has been perceived and depicted in different eras, I aimed to convey several key insights to readers. Firstly, I wanted to stress that beauty and ugliness are subjective and culturally constructed concepts. They vary over time, across cultures, and even within individuals. Secondly, I wished to highlight how the depiction of ugliness in art has served multiple purposes, often challenging established norms, beliefs, and aesthetic conventions. Ugliness can provoke thought, critique, and introspection. Overall, my goal was to encourage readers to question the perceived dichotomy between beauty and ugliness, to recognize their fluidity, and to ponder how this tension has influenced human perception, creation, and interpretation throughout history. Throughout history, the concept of ugliness has been subject to cultural fluctuations. An intriguing example lies in the portrayal of physical beauty in art. Renaissance paintings often emphasized the human body's idealized forms, disregarding imperfections. However, modern art movements like Cubism and Surrealism challenged these norms, incorporating unconventional and, to some, "ugly" representations. Another area where perceptions of ugliness are evident is in fashion. In ancient China, bound feet were considered attractive, whereas today it is seen as a painful and deforming practice. In Victorian England, a pale complexion was highly desired, with women even using lead-based cosmetics to achieve a ghostly appearance. In contrast, tanned skin is now often perceived as attractive due to its association with health and leisure. These examples illustrate how cultural factors shape notions of ugliness. Social values, historical contexts, and influential figures such as artists, designers, and media play a significant role in defining what society considers unattractive. These understandings are not fixed, but fluid, evolving as cultures change and new aesthetic ideals emerge. In conclusion, perceptions of ugliness transform over time as cultural factors shape our understanding of beauty. Art, fashion, and social values are just some of the spheres wherein these transformations occur, illustrating both the subjective nature of ugliness and its malleability within different cultures and historical periods. In the realm of aesthetics, beauty and ugliness are intertwined and reliant on each other. The concept of beauty gains significance in the presence of ugliness, as it allows for comparison and contrast. Ugliness serves as a powerful catalyst to accentuate the qualities we perceive as beautiful. The interplay between beauty and ugliness is not solely about opposition; rather, it is a dynamic relationship. Our perception of beauty is subjective and influenced by cultural, social, and personal factors. The absence of ugliness may diminish our ability to recognize and appreciate beauty, as it would lack a contrasting element. Ugliness acts as a reminder of imperfection, allowing us to perceive beauty more profoundly. Moreover, the presence of ugliness challenges our notions of beauty and can even redefine it. Ugly elements can be incorporated into art, architecture, or even fashion to create unconventional beauty. By evoking emotions and discomfort, ugliness prompts us to question established standards and reevaluate our concept of beauty. Ultimately, the interplay between beauty and ugliness is a complex, intertwined dance that shapes our perception of aesthetics. Without the presence or absence of ugliness, our understanding and appreciation of beauty would lose its depth and diversity. 5.Your research explores the role of ugliness in art and its potential to evoke strong emotional responses. Can you discuss how artists have used ugliness as a tool for expression, and what messages or themes can be conveyed through the portrayal of ugliness in art? 6.The book addresses the social and psychological implications of ugliness. Can you discuss how perceptions of ugliness can influence our interactions with others, and how societal standards of beauty and ugliness can impact individuals' self-esteem and well-being? 7."On Ugliness" also examines the notion of grotesque and its relationship with ugliness. Can you explain the concept of the grotesque and how it has been depicted in art and literature, and what insights can be gained from studying the grotesque? 8.Your work touches on the cultural construction of beauty ideals and the influence of media on our perceptions of beauty and ugliness. Can you discuss the role of media in shaping societal standards of beauty, and how can individuals develop a more nuanced understanding of beauty beyond what is portrayed in the media? 9.The book explores the dichotomy between the ideal and the real, and how it relates to the concept of ugliness. Can you discuss the tension between these two concepts and how it manifests in different aspects of life, such as art, architecture, and human appearance? 1. "The History of Beauty" by Umberto Eco: This book complements Eco's "On Ugliness" by exploring the concept of beauty throughout history. Eco delves into art, literature, and philosophy to examine the multifaceted nature of beauty, providing insights into how cultural and historical contexts shape our perceptions. 2. "The Art instinct: Beauty, Pleasure, and Human Evolution" by Denis Dutton: Dutton explores the link between our innate aesthetic preferences and human evolution. Drawing on evolutionary biology and anthropology, he discusses how our sense of beauty emerges from our evolutionary past, examining its influence on art, aesthetics, and our daily lives. 3. Ways of Seeing" by John Berger: This influential book offers a critical analysis of visual culture and challenges the way we perceive art. Berger explores the power dynamics and social constructs behind images, bringing to light the hidden meanings and ideological biases that shape our interpretations of beauty and ugliness. 4. The Metamorphosis of Plants" by Johann Wolfgang von Goethe: Goethe's work explores nature's transition from simplicity to complexity, shedding light on the beauty hidden within natural processes. This scientific and philosophical essay reflects on the transformations plants undergo and unveils their aesthetic significance, inspiring readers to view the natural world with a renewed sense of wonder. 5. The Picture of Dorian Gray" by Oscar Wilde: Wilde's classic novel explores the notion of beauty and its destructive potential. As Dorian Gray indulges in a life of hedonism while his portrait ages and deteriorates, Wilde raises questions about the true nature of beauty and the consequences of its pursuit, exposing the dark underbelly of superficial aesthetics.
To understand the origin of production variances, we first start with an overview of the underlying production process for discrete manufacturing industries and the variance categories. The figure above gives you an overview of the production process. - The production order type controls whether the order is also a cost object and is therefore used for the cost object invoice. In this example, this is true. When the production order is created, the planned costs are calculated based on the planned production quantity in the order. - The material withdrawal is booked. Multiplying the quantities of raw materials posted as goods issue by their prices leads to actual material costs. - The result of the completed production steps is recorded in the confirmation of the production order. The actual times recorded for the work processes of the production order are multiplied by the cost center services assigned to the work processes, resulting in the production costs. - The recorded actual yield quantities that have been produced are posted as goods receipt. This leads to a cost credit posting for the production order as a cost object. - In addition, further individual costs can be added to the order as a debit entry. For example, if additional third-party services had to be ordered. - In the scenario used here, the so-called order-related product cost controlling, the goods receipt of the last final confirmation for the production order means that the order is completed. The system sets the status DELIVERED in the order when the actual yield quantity has been posted a goods receive to the warehouse. - When the deviation determination is carried out, the system calculates the target costs. These results are calculated by multiplying the total recorded actual yield quantity by the calculated manufacturing costs per piece. Fixed plan costs are equal to fixed target costs, but the variable plan cost per piece is multiplied with the yield quantity. - The target-actual variances between the target costs and the actual costs are calculated according to different variance categories. These include, for example, quantity variances and price variances of the materials used as well as cost center activities. When the cost object is created, a preliminary cost estimate is performed automatically to calculate the planned costs for the cost object. The following types of costs are incurred at different stages of production and processing: - Actual costs are incurred when materials from stock or activity types of cost centers are consumed. - Primary costs can be incurred directly from the other system components to the production order. - Process costs can be incurred by allocating process quantities using the process template. Because the related costs are posted to the production order at the same time as the consumption of materials and activity, production order costs can be analyzed and reviewed at any time. When the produced goods are delivered to stock, the cost object is credited with the value of the delivered quantity, and the goods are capitalized on in the inventory. Depending on the method of price control, this can result in a revaluation of the finished goods inventory. In this example, you use a standard price-controlled material. SAP recommends the valuation of material stock using the material cost estimate for self-finished goods. With the final confirmation of the production order in a make-to-stock scenario and cost-object method Product Cost by Order, the yield quantity debits the cost object and credits the goods in stock. After finishing the production process or at the end of the period, the variances for the production order are calculated and settled to FI and Margin Analysis. Production Process in a Make-to-Stock Scenario Let's now see an example for the production process in a make-to-stock scenario. To calculate the deviations, the production order is not only a logistics object but also a cost object. The order type for which the production order is created controls this. In its capacity as a cost object, all planned and actual costs are assigned to the production order. This can also be used to calculate production deviations. We create the production order directly without deriving it from production planning. A production order refers to a material number, plant, and an order type. Here, the material FG1_CP, plant 1010 and order type YBM5. The order type contains the parameters for controlling the processes with the production order, for example, that the production order is also a cost object and therefore bears all planned and actual costs. It is also controlled by the used order type (YBM3) whether Production variances are calculated automatically or by running an app. In our example, the variances are not calculated automatically (event-based posting), but by running an app. A settlement rule for the production order is automatically generated which defines that the confirmed yield quantity multiplied with the released standard price will be automatically credited the cost object production order when the confirmed yield quantity will be posted as goods receipt. When performing the plan-to-product process the posting of the goods issue is or one needed raw material increased by one pc. This leads to a quantity variance when determining variances from the production order. The following figure shows the confirmation for the production order and operation No. 0020. Of the 10 pieces planned for the product FG1_CP, 10 pieces are confirmed as yield quantity and 0 piece as scrap quantity. The confirmation to operation 0020 is marked as final confirmation. This means that any remaining actual costs on the production order are calculated as variances and not as work in progress (WIP). To be able to calculate the variances, you must post the good receipt regarding the confirmed yield quantity in the final confirmation of the production order. With this final delivery of yield quantity, the status of the production order will be set to GLFL (Delivered). Only with status, it is possible to calculate variances. The system will also create automatically the settlement rule, when the variances of the production order will be settled to Financial Accounting. As the previous figure shows, the reported actual quantity of 10 pieces is posted as a goods receipt. The production order is thus credited by 10 pieces multiplied by the calculated manufacturing costs per piece. An actual balance that remains on the production order is variance. The following figure shows the accounting document with the posting of the goods receipt of the actual yield quantity. Because of the final confirmation and the goods receipt of the actual good quantity, the status DLV (delivered) and the indicator for Delivery Completed are automatically set in the production order. The production order is now completed, and the actual cost balance is interpreted as a variance. Now let's calculate the variances of the production order. The figure above shows that the consolidated variance categories are 52,62 EUR. This is named Price Difference of Self-Production. With a click on the line and the selection of Cost Elements the variance categories could be analyzed. You can click on each line of the variance calculation list to analyze, which variance category has been calculated. The figure above shows the variances for the raw material RM2_CP of 1, - EUR is a variance category Quantity Variance. This corresponds to the goods issue posting for the production order, in which a goods issue quantity of 21 pieces was posted for the raw material instead of the planned 20 pieces. Calculating the price difference of EUR 52.62 relieves the debit on the production order and can be tracked and evaluated on the reports in Margin Analysis. The previous figure shows that the price difference from the production order has been settled to Profitability Segment (PSG). The debit and credit postings on the production order result in a difference of EUR 52.62, which corresponds to the price difference of the cost object. This can be evaluated on the line-item report in Margin Analysis. The evaluation of the variance categories is presented in the next lesson with the Product Profitability with Variances report. This report can be used to evaluate the influence production deviations have on the profitability of the products.
We examine the Core Values of American Democracy and discuss their importance and where we are exposed to them and practice them throughout life. Filter by subjects: Filter by audience: Filter by unit » issue area: find a lesson Unit: The Power of Children Students determine which community need they want to address with a service project. Once a priority need has been determined, they research related nonprofit organizations with a student-generated list of questions. Unit: Bully-Free Zone The learners reflect on a literature book written from the viewpoint of someone who used to bully others, Confessions of a Former Bully. They analyze the data collected from their survey to determine how bullying behavior affects their school. They learn that addressing... Unit: Nonprofits are Necessary (6-8) The purpose of this lesson is to have students name and recognize nonprofit organizations within the local community. Unit: Why Do We Have a Census? This lesson explains what the Census is and why it is important for everyone. Every ten years, we count everyone who is living in the U.S., from babies to the oldest people. This gives our government a clear idea of who lives where and regions where we have growth or decrease in population... This secondary lesson explains what the U.S. Census is and why it is important for everyone. Every ten years, we count everyone who is living in the U.S., from babies to the oldest people. This gives our government a clear idea of who is using services and where we have growth or decrease in... Unit: Environment: Sustaining Our World The youth take action by determining ways to reduce their own use of plastic bags and by advocating for ways to reduce the use of plastic bags in their own households, the community, state and nation. To take further action, they may propose ways to influence government officials... Unit: Wall of Philanthropists After reading about historical figures who have taken philanthropic action related to justice, youth write a narrative about a more recent (young) philanthropist who took action for social justice. Unit: Heroes and Their Impact Jackie Robinson is a baseball player whose perseverance and strength changed racist attitudes and laws. Participants reflect on Mr. Robinson's actions and make connections to personal actions and to the people they admire today. Unit: TeachOne Back to School Youth reflect on the value of art in communicating feelings and culture, while taking part in service to the community. They teach an art lesson to young children to encourage self-expression. They plan an environmental service project that puts crayons in the hands of young children. The youth...
When the exhibition, Hear Me Now: The Black Potters of Old Edgefield, South Carolina, began its run at the Metropolitan Museum of Art, it was likely the first time many people in the northeast had considered the narratives embedded within the stoneware production of Old Edgefield District, the center for American ceramic creation before the Civil War. The High Museum of Art in Atlanta, The Charleston Museum, Greenville County Museum of Art, Mckissick Museum, and South Carolina State Museum brought this story to life via objects from their permanent collections. So, why did the High need to bring this exhibition south? There is regional relevance and proximity to historical context, but this is also an opportunity for historical accountability. Slavery in America has traditionally been perceived as predominantly agricultural, the majority of the enslaved people laboring in the cultivation of cash crops (cotton or tobacco fields). Sometimes the artistic merits of the many churns, storage jars, pitchers, bowls, and jugs are noted, but rarely is the industrial scale in which these products were produced highlighted. The exhibit's focal point is the work of Dave (later recorded as David Drake), a potter born into slavery around 1801 in South Carolina. Dave became exceptional not only for his craftsmanship but also for his ability to read and write—in a time when literacy among enslaved people was forbidden. He is best known for the large storage jars he crafted, some capable of holding over forty gallons. What truly set Dave apart was the elegant cursive inscriptions he carved into his pots, ranging from poetic verses to simple, poignant reflections on his life and times. One such jar, inscribed with the date 1858, spoke of the symbolism and cruelty of selling enslaved people on New Year's Day. He wrote: "nineteen days before Christmas—Eve— / Lots of people after its over, how they will greave." The beginning of the year was a time for owners of enslaved people to settle debts and manage financial affairs by buying, selling, or leasing slaves, often causing deep fear among enslaved people and suddenly stripped of family connections. Dave employed rhyme to contrast the festive spirit of Christmas with the looming sorrow that follows. Dave's jars are contextualized alongside other ceramic objects, including face vessels and utilitarian wares, many by unknown artists. These pieces, crafted under cruel conditions, represent a blend of skill, resilience, and silent resistance. In an exhibition of stunning works of art, it was odd to be focused on a didactic image. Besides a case with four shards from broken vessels, the curators included a recent photo taken on private land in Edgefield. In the image, uneven ground strewn with the remnants of shattered ceramics in muted earth tones and faded glazes. Pottery production had escalated to an industrial level, necessitating substantial capital and resources to maintain it. This ceramic graveyard shows the economic, industrial, political, social, and artistic developments in the nineteenth century. As the trail of broken ceramics extend beyond the image, one can almost see the wagon roads, waterways, and the Charleston-Hamburg Railroad, which helped transport stoneware as far as 150 miles away. One of my favorite works is a storage jar from an Unrecorded potter, possibly from the Phoenix Stone Ware Factory or Collin Rhodes Factory, ca. 1840-53, which features both brushed iron slip and slip-trailed kaolin decoration on each side. The back side depicts a stylized silhouette of a peony in bloom with open petals, bringing the jar a sense of elegance and sophistication, suggesting it could have served practical purposes or acted as a decorative piece in a middle-class Southern home. On the other side, we see the profile of a man in uniform, either military or formal dress, animated by his distinctive posture, fluid movement, expressive wide eye and button ear, and mouth open in a toothy grin, the details piped onto the vessel's surface like icing on a cake. This decoration is particularly intriguing because there are so few instances in early nineteenth century American history where African Americans or enslaved individuals are depicted in artistic works, making the prominent depiction of this individual exceptionally notable as it counters the widespread historical invisibility and marginalization of African Americans. The exhibition attempts to bridge past and present by featuring contemporary works by artists like Theaster Gates, Adebunmi Gbadebo, Simone Leigh, and Woody De Othello, each of whom draws direct inspiration from the legacy of Edgefield's potters. In this fourth iteration of the installation of the exhibition, the curators create a dialogue across the centuries, providing the platform for these conversations to happen side-by-side, as opposed to in jarring jumps. The installation at the High sets the tone immediately with a Storage jar by Drake and Baddler, Stony Bluff Manufactory, 1859, placed directly beside Woody De Othello's vessel Secrets Safe, 2022. The work, covered in ears, represents the collective listening that needs to happen throughout the exhibition. Due to its closeness to the Drake, it signifies heeding historical echoes and spiritual communication. This is not just an exhibition; it is an act of reclamation and remembrance, urging a reassessment of history and artistry through pottery. Later in the exhibition, viewers are greeted by Simone Leigh's epic Large Jug, 2022. The jug's surface is finished with a rich white slip, in direct contrast to the earthy face jug ca. 1850-1880, which sits nearby and is a direct reference for Leigh's work. Leigh's vessel is covered in cowrie shells, symbols of womanhood, fertility, birth, and wealth. Still, it is also informed by the expressive facial features of old face jugs, including their prominently displayed teeth. While the shells have this serrated edge, the face jugs bare their teeth in either a grimace or a smile, each representing protection. In its first incarnation, the exhibition was hindered by the spatial constraints of the Met's Lehman Wing. In Atlanta, with the most square footage of any stop on the tour, the exhibition encourages a deeper exploration and understanding of the complexities of American history, particularly Southern history, through the lens of art and craftsmanship. This is not just an exhibition; it is an act of reclamation and remembrance, urging a reassessment of history and artistry through pottery.
Scoliosis & Deformity Correction Surgery When correcting a curve or deformity in the spine, we employ minimally invasive techniques and technologies to cause as little disruption as possible to the patient. Surgical tools that we use include robotic guidance, stealth navigation, ultrasonic or laser cutting devices. The goal of spinal reconstruction surgery is to decrease the patient's pain and to place the spine in a more natural position. This can be accomplished using minimally invasive robot-guided spine surgery which allows our surgeons to precisely create and plan a blueprint for surgery before stepping foot in the operating room. Types of Spinal Deformity Surgeries Living Life Again At VSI, we celebrate every patient's unique journey as a series of victories, regardless of how big or small. Our logo and brand were crafted for you, our incredible patients. Your progress towards your goals deserves the spotlight, reflecting our commitment to individualized treatment and care. Your Victories are what make VSI who we are! #MyVictoryStory Discover the Benefits Of Spinal Deformity Surgeries Scoliosis and deformity corrective surgeries help to realign the spine in patients with abnormal curvatures, as well as: - Decrease the patient's pain - Prevents progression of deformity - Place the spine in a more natural position - Decrease numbness and weakness - Place the spine in better balanced position for better function - Give patients an improved quality of life Frequently Asked Questions Spinal Deformity Surgeries
Click name to view affiliation Sport participation or regular physical activity is often seen as a factor, which leads to better health and well being. Sport also has a social function, as most of the activities are performed together with other people. However, while club sports in Sweden have a stimulating effect on young men, there is a risk that they do not provide enough scope for young women. In particular, early specialization and a high level of seriousness do not suit all young sportswomen. The purpose of this study was to develop a theoretical understanding of the ways in which sport has influenced young women's lifestyles in terms of their attitudes to physical activity in adult life. The data were collected using strategic interviews and analyzed using the grounded theory method. Based upon the results, young women's physically active lifestyles varied depending on how they valued their sport in combination with how they handled their sport. Sport was regarded as having a positive effect on health and well being. This led to the young women studied intending to pursue a physically active lifestyle also in adult life. They enjoyed participating in sport, but not particularly sport with a high level of seriousness or a high level of vigor, which is what characterizes most club sports today. Bengt Fridlund, UCN, BSc (educ), UDNE, PhD is a professor at School of Social & Health Sciences, Halmstad University, Halmstad, Sweden. He is also an associate professor in the departments of Nursing Science, Kuopio University, Kuopio, Finland and Primary Health Care, Gijteborg University, Goteborg, Sweden. Dr. Fridlund is a senior lecturer at the School of Social & Health Sciences, Halmstad University, Halmstad, Sweden and his research interest concerns social network/support and QoL issues related to health promotion and disease prevention programs. Ulla Tebelius, PE teacher, AE teacher, BA (Ed.Sc), PhD. She is associate professor and head of the section of Educational Sciences at the School of Social & Health Sciences, University of Halmstad. She is in charge of a program on gender research at the Centre of Work Life Research and Development. She is heading a research project focused on Teenage Girl in Sport. Her main interest, however, is Adult learning and learning in working life. Eva-Carin Lindgren, Sport pedagogue, BSc (educ), MSc (educ), doct candidate, is a junior lecturer and researcher at the School of Social & Health Sciences, Halmstad University, Halmstad, Sweden. She is heading a research project focused on young women in sport. Her research interest concerns your women and physical activity/exercise/sport related to health promotion programs.
Overcoming Hesitancy: Men's Health Importance Understanding Men's Clinics and Their Role in Men's Health Men's clinics have emerged as a specialized healthcare option that caters specifically to men's unique health needs. These clinics understand the importance of creating a comfortable and supportive environment that encourages men to seek the care they require. From preventive screenings to the treatment of specific conditions, men's clinics offer a comprehensive range of services that address physical, emotional, and sexual health concerns. With a focus on personalized care and tailored treatment plans, men's clinics aim to empower men to take charge of their health and well-being. In Meridianville, the demand for specialized men's healthcare services has led to the establishment of a state-of-the-art men's clinic that is dedicated to addressing the diverse needs of the male population. This clinic provides a wide array of services, including advanced treatments such as Extracorporeal Shock Wave Therapy, which has garnered attention for its potential to address various men's health issues. The Role of Extracorporeal Shock Wave Therapy (ESWT) in Men's Health Extracorporeal Shock Wave Therapy, commonly referred to as ESWT, is a non-invasive medical treatment that utilizes shock waves to promote healing and tissue regeneration within the body. Originally developed for the treatment of kidney stones, ESWT has evolved to become a versatile therapeutic option for a range of musculoskeletal and urological conditions. In the realm of men's health, ESWT has shown promise in addressing erectile dysfunction, Peyronie's disease, and chronic pelvic pain syndrome, among other conditions. The therapy works by stimulating the body's natural healing processes, promoting the growth of new blood vessels and tissue repair in targeted areas. This can lead to improved blood flow, tissue regeneration, and enhanced overall function in the affected areas. For men in Meridianville and surrounding areas, the availability of ESWT at a local men's clinic represents a significant advancement in the accessibility of cutting-edge treatments. By offering this innovative therapy, the clinic is equipped to cater to the specific health needs of its male clientele, fostering a proactive approach to men's health. The Benefits of Seeking Treatment at a Specialized Men's Clinic Specialized men's clinics offer several distinct advantages for men seeking healthcare services. These clinics are staffed by healthcare professionals who are experienced in addressing men's health concerns and are attuned to the unique physical and emotional aspects of male wellness. This expertise, coupled with a focus on personalized care, ensures that men receive tailored treatment plans that align with their individual health goals and needs. Moreover, the environment of a men's clinic is designed to be welcoming and supportive, eliminating potential barriers to seeking care. By creating a space where men feel comfortable discussing sensitive health issues, specialized clinics foster open communication and promote proactive engagement in healthcare. This can lead to early detection of health conditions, timely intervention, and improved outcomes for men's health overall. The presence of ESWT at a men's clinic further enhances the range of services available, offering men an innovative treatment option with the potential to address specific health concerns effectively. The convenience of accessing advanced treatments within a familiar and supportive healthcare setting can encourage men to take proactive steps toward better health, ultimately contributing to improved quality of life and well-being. Choosing a Men's Clinic for Comprehensive Men's Health Care When considering a men's clinic for comprehensive healthcare services, it is essential to evaluate the clinic's expertise, range of services, and commitment to personalized care. A reputable men's clinic should prioritize the well-being of its patients, demonstrating a deep acknowledging of men's health issues and a proactive approach to preventive and therapeutic interventions. In Meridianville, men have the opportunity to access a men's clinic that embodies these fundamental principles, providing a diverse range of services tailored to men's specific health needs. From preventive screenings and wellness exams to advanced treatments like ESWT, the clinic aims to serve as a trusted healthcare partner for men in the local community. By choosing a men's clinic that emphasizes excellence in care and places a strong emphasis on patient comfort and well-being, men can proactively manage their health and address any concerns with the support of expert healthcare professionals. This approach empowers men to prioritize their health and take proactive steps toward achieving and maintaining optimal well-being. Concluding perspectives The emergence of specialized men's clinics has ushered in a new era of healthcare tailored to the unique needs of men. In Meridianville, Alabama, the presence of a cutting-edge men's clinic offering services such as Extracorporeal Shock Wave Therapy represents a significant advancement in men's healthcare accessibility. By providing a welcoming and supportive environment and offering innovative treatment options, men's clinics are empowering men to prioritize their health and well-being. As men across the United States continue to recognize the importance of seeking specialized care for their health needs, the role of men's clinics in promoting holistic well-being will undoubtedly become increasingly significant. Whether seeking preventive care, screening services, or advanced treatments like ESWT, men can turn to specialized men's clinics for comprehensive and personalized healthcare solutions that prioritize their unique health needs.
Being a stay-at-home parent is a ton of work that often goes unrecognized. A new study shows how much they would be earning in a traditional job with similar hours and responsibilities. Being a stay-at-home parent is a ton of work that often goes unrecognized. A new study shows how much they would be earning in a traditional job with similar hours and responsibilities. Being a stay-at-home parent is a choice that every family has to make together, but it's a tricky thing to navigate financially. The unfortunate thing is that all of the labor that stay-at-home parents goes unpaid. A new study by Salary.com decided to crunch some numbers and calculate what a traditional job with hours and responsibilities similar to a stay-at-home parent's would be, and the results might shock you a bit. According to their "Salary Wizard," the median pay for stay-at-home parents should be $162,581. By taking into account the long hours and all of the different roles that a stay at home parent plays, Salary.com decided that was the fair salary. It was $5000 higher than the 2017 assessment. It's safe to say that being a stay-at-home parent is a ton of work, and there isn't always a lot of praise or reward (outside of the pride that comes from caring from your family, of course) for doing the job. In a perfect world, everyone would be fairly compensated for the job that they do. Stay-at-home parents put in long hours and work hard to care for their families. Wouldn't it be nice to see them fairly compensated? Twitter, of course, weighed in, with people cracking jokes about the workplace and fellow employees. Some people agreed with the study, pointing out how hard it can be to take care of the kids and the home. Life is hard and parents keep things afloat through sheer grit and patience. However, others were quick to point out that this is what they signed up for having a family. Whether you agree with the assessment or not, it's safe to say that stay-at-home parents don't get enough credit for all the hard work that they do. So thanks for keeping the lights on and everyone fed, moms and dads. You guys are the real heroes. The lovely part of a theoretical discussion on something like this is how many people take it seriously. Nobody is going to actually pay this, but they use comparisons and other methods to figure it out -- IF someone were to pay for this. So in the end, only Douglas here is paying for it. A few other folks wanted to know if it was possible to collect this kind of pay and then the pay they get from their job at the same time. Two income families. Might seem greedy, but it is trouble to juggle everything, so why not?
Welcome to our comprehensive guide on calculating the volume of a pyramid using our user-friendly volume of a pyramid calculator. This article will walk you through the steps of using the calculator and provide you with a detailed explanation of the formula behind the calculations. Whether you're a student tackling geometry problems or a professional working in architecture or engineering, our volume of a pyramid calculator is designed to make your life easier. Our calculator simplifies the process of calculating the volume of various types of pyramids, from regular to irregular. We aim to provide accurate results while ensuring an enjoyable and hassle-free experience. So, let's dive into the world of pyramids and explore the formula that helps us determine their volume. To proceed with the calculations, we'll need some information about the pyramid you're working with. The formula for the volume of a pyramid is V = (1/3) * B * h, where V represents the volume, B is the area of the base, and h is the height of the pyramid. Our calculator takes care of the mathematical calculations, so you can focus on providing the required information. volume of a pyramid calculator Our volume of a pyramid calculator offers a range of features: - User-friendly interface - Accurate calculations - Supports various pyramid types - Detailed step-by-step solutions - Multiple unit options - Instantaneous results - Free to use - Accessible on any device With our calculator, you can easily calculate the volume of your desired pyramid, whether it's a regular or irregular one. User-friendly interface Our volume of a pyramid calculator is designed with simplicity and ease of use in mind. We understand that navigating complex interfaces can be frustrating, especially when you're dealing with mathematical calculations. That's why we've created an intuitive interface that guides you through the process seamlessly. The calculator features a clean and organized layout, with clearly labeled fields for entering the necessary information. Simply select the type of pyramid you're working with, input the relevant measurements, and hit the "Calculate" button. Our calculator takes care of the rest, providing you with accurate results in an instant. To enhance the user experience further, we've included detailed instructions and helpful tooltips throughout the calculator. These resources provide additional guidance and ensure that you're using the calculator correctly. Whether you're a student encountering pyramids for the first time or a professional dealing with complex pyramid calculations, our user-friendly interface makes the process effortless and enjoyable. Furthermore, our calculator supports multiple unit options, allowing you to enter measurements in the units you're most comfortable with. This flexibility eliminates the need for manual conversions, saving you time and reducing the risk of errors. Our user-friendly interface makes calculating the volume of a pyramid a breeze. With its intuitive design, clear instructions, and comprehensive features, our calculator caters to users of all levels, ensuring a smooth and efficient experience. Accurate calculations Our volume of a pyramid calculator is built on a robust mathematical foundation, ensuring the accuracy of its results. We understand that precision is paramount, especially when dealing with calculations related to geometry and engineering. That's why we've implemented rigorous algorithms and formulas to guarantee reliable outcomes. Our calculator leverages the standard formula for calculating the volume of a pyramid: V = (1/3) * B * h, where V represents the volume, B is the area of the base, and h is the height of the pyramid. This formula is applicable to various types of pyramids, including regular and irregular ones. Our calculator accurately handles the calculations for each type, taking into account the specific characteristics of the pyramid. To further ensure accuracy, our calculator employs multiple levels of verification. Each calculation undergoes a series of checks to identify and eliminate potential errors. This multi-step process minimizes the chances of incorrect results and provides you with confidence in the reliability of the calculator's output. Additionally, our calculator allows you to specify the number of decimal places in the final result. This flexibility enables you to tailor the precision of the calculations to your specific requirements. Whether you need a quick estimate or a highly accurate value, our calculator delivers the results you need. With its sophisticated algorithms, rigorous verification process, and customizable precision, our volume of a pyramid calculator ensures accurate and reliable results every time. Supports various pyramid types Our volume of a pyramid calculator recognizes that pyramids come in various shapes and forms. To cater to this diversity, our calculator supports a wide range of pyramid types, ensuring that you can calculate the volume of any pyramid you encounter. The calculator handles both regular and irregular pyramids with ease. Regular pyramids, such as square pyramids and triangular pyramids, have bases with regular polygons. Irregular pyramids, on the other hand, have bases with irregular polygons. Our calculator can accurately determine the volume of both types, regardless of their complexity. Furthermore, our calculator supports pyramids with different orientations. You can calculate the volume of a pyramid whether it's standing upright, lying on its side, or tilted at an angle. This versatility makes our calculator a valuable tool for solving a variety of problems involving pyramids. To use our calculator, simply select the type of pyramid you're working with from the provided options. The calculator will then guide you through the process of entering the necessary measurements. Whether you're dealing with a regular square pyramid, an irregular triangular pyramid, or a pyramid with a unique base shape, our calculator has you covered. With its comprehensive support for various pyramid types and orientations, our volume of a pyramid calculator is the perfect tool for tackling any pyramid-related calculations you may encounter. Detailed step-by-step solutions Our volume of a pyramid calculator not only provides accurate results but also guides you through the calculation process with detailed step-by-step solutions. Easy-to-follow instructions: Our calculator presents a clear and concise breakdown of the calculations. Each step is explained in simple, easy-to-understand language, making it accessible to users of all levels. Visual representations: To further enhance understanding, our calculator incorporates visual representations, such as diagrams and graphs. These visual aids help you visualize the pyramid and its dimensions, making the calculations more intuitive. Formula explanations: Our calculator doesn't just show you the results; it also explains the formulas and principles behind the calculations. This not only helps you understand the process but also provides valuable insights into the mathematics of pyramids. Interactive interface: Our calculator features an interactive interface that allows you to adjust the values of the pyramid's dimensions and see how they affect the volume in real time. This interactive approach makes learning and experimentation enjoyable and engaging. With its detailed step-by-step solutions, visual representations, formula explanations, and interactive interface, our volume of a pyramid calculator transforms complex calculations into an educational and enjoyable experience. Multiple unit options Our volume of a pyramid calculator understands that users may prefer different units of measurement. To accommodate this, our calculator offers a wide range of unit options, allowing you to perform calculations using the units you're most comfortable with. Flexibility and convenience: With our calculator, you can choose from a variety of units for length, including inches, centimeters, meters, feet, and yards. This flexibility eliminates the need for manual conversions, saving you time and reducing the risk of errors. International accessibility: Our calculator's support for multiple units makes it accessible to users from different countries and cultures. Whether you're working with metric or imperial units, our calculator has you covered. Real-world applications: The ability to use different units allows you to apply our calculator to various real-world scenarios. From architectural projects to engineering calculations, our calculator adapts to your specific needs and preferences. Educational value: Our calculator can serve as an educational tool for students learning about units of measurement and their conversions. By experimenting with different units, students can gain a deeper understanding of the relationships between them. With its comprehensive support for multiple unit options, our volume of a pyramid calculator caters to users from all backgrounds, making it a versatile and user-friendly tool for a wide range of applications. Instantaneous results Our volume of a pyramid calculator is designed to provide instantaneous results, saving you valuable time and eliminating the frustration of waiting. As soon as you enter the necessary information and click the "Calculate" button, our calculator swiftly generates the volume of the pyramid. This lightning-fast calculation speed is made possible by our optimized algorithms and efficient programming techniques. We understand that in today's fast-paced world, you need quick and reliable answers to your calculations. Our calculator delivers just that, allowing you to move forward with your work or studies without any delays. The instantaneous results feature of our calculator is particularly beneficial in situations where time is of the essence. For example, if you're an architect or engineer working on a tight deadline, our calculator can provide you with the necessary volume calculations in a matter of seconds. This allows you to stay on track with your project and meet your deadlines with confidence. Moreover, the immediate availability of results makes our calculator an excellent tool for educational purposes. Students can use our calculator to quickly check their answers during practice problems or exams. This helps them identify any errors and reinforce their understanding of the concepts. With its instantaneous results, our volume of a pyramid calculator streamlines your calculations, saves you time, and enhances your overall productivity. Free to use Our volume of a pyramid calculator is completely free to use, without any hidden charges or subscription fees. We believe that education and access to knowledge should be available to everyone, regardless of their financial means. By offering our calculator for free, we aim to remove any barriers that may prevent students, researchers, and professionals from utilizing this valuable tool. We want to empower individuals to learn, explore, and solve problems without having to worry about additional costs. The free nature of our calculator also makes it an attractive option for educators and institutions. Teachers can incorporate our calculator into their lessons to provide students with an interactive and engaging way to learn about pyramids and their volume. Schools and universities can also use our calculator as a resource for students to practice their mathematical skills and reinforce their understanding of geometry concepts. Furthermore, our free calculator promotes inclusivity and accessibility in education. By eliminating financial barriers, we ensure that everyone has the opportunity to use our calculator and benefit from its features, regardless of their background or circumstances. Our commitment to providing a free volume of a pyramid calculator aligns with our mission of making education and knowledge accessible to all. We believe that everyone should have the tools they need to succeed, and our calculator is a small but meaningful contribution towards achieving this goal. Accessible on any device Our volume of a pyramid calculator is designed to be accessible on any device with an internet connection. Whether you're using a laptop, desktop computer, tablet, or smartphone, our calculator is optimized to provide a seamless experience on all platforms. This cross-device accessibility is particularly useful in today's mobile world. You can access our calculator from anywhere, at any time, making it a convenient tool for students, professionals, and anyone else who needs to calculate the volume of a pyramid. The responsive design of our calculator ensures that it adapts to different screen sizes and resolutions. This means that you can use our calculator on a small smartphone screen or a large desktop monitor with equal ease. The calculator automatically adjusts its layout and elements to fit the available space, providing an optimal user experience regardless of the device you're using. Furthermore, our calculator works with various operating systems, including Windows, macOS, iOS, and Android. This wide compatibility ensures that you can use our calculator on your preferred device, without having to worry about compatibility issues. By being accessible on any device, our volume of a pyramid calculator caters to the diverse needs of users in different environments. Whether you're at home, in the office, or on the go, our calculator is always at your fingertips, ready to help you with your pyramid-related calculations. To assist you further, we've compiled a list of frequently asked questions (FAQs) about our volume of a pyramid calculator: Question 1: What types of pyramids can your calculator handle? Answer 1: Our calculator supports both regular and irregular pyramids. Regular pyramids have bases with regular polygons, such as squares or triangles, while irregular pyramids have bases with irregular polygons. Question 2: Can I use different units of measurement? Answer 2: Yes, our calculator offers a wide range of unit options for length, including inches, centimeters, meters, feet, and yards. You can choose the units you're most comfortable with. Question 3: How accurate are the results? Answer 3: Our calculator employs sophisticated algorithms and rigorous verification processes to ensure accurate results. You can also specify the number of decimal places in the final result to suit your precision requirements. Question 4: Is your calculator free to use? Answer 4: Yes, our volume of a pyramid calculator is completely free to use. We believe that education and access to knowledge should be available to everyone. Question 5: Can I access the calculator on any device? Answer 5: Our calculator is accessible on any device with an internet connection. It works on laptops, desktops, tablets, and smartphones, and is compatible with various operating systems. Question 6: Is there a limit to the number of calculations I can perform? Answer 6: No, there is no limit to the number of calculations you can perform with our calculator. You can use it as many times as you need, without any restrictions. Question 7: Can I save my calculations for later reference? Answer 7: Currently, our calculator does not have a feature to save your calculations. However, you can easily perform the calculations again whenever you need them. Closing Paragraph for FAQ: We hope these FAQs have addressed any questions you may have about our volume of a pyramid calculator. If you have any further inquiries, please don't hesitate to contact us. We're always happy to help. Now that you're familiar with our calculator's features and capabilities, let's explore some tips to help you get the most out of it. To help you make the most of our volume of a pyramid calculator, here are a few practical tips: Tip 1: Understand the concept of pyramid volume: Before using the calculator, take some time to understand the concept of pyramid volume and the formula used to calculate it (V = (1/3) * B * h). This will help you appreciate the significance of the measurements you input and the results you obtain. Tip 2: Double-check your measurements: Make sure you accurately measure the base area and height of the pyramid before entering them into the calculator. Even a slight error in measurement can lead to an incorrect volume calculation. Tip 3: Choose the appropriate units: Our calculator offers a variety of unit options for length. Select the units that are most relevant to your project or application. This will ensure that you can easily interpret and use the results. Tip 4: Utilize the step-by-step solutions: If you're unsure about how the calculator arrives at the result, take advantage of the detailed step-by-step solutions. These solutions provide a breakdown of the calculations, making it easier to understand the process and identify any errors. Closing Paragraph for Tips: By following these tips, you can ensure that you use our volume of a pyramid calculator effectively and accurately. Whether you're a student, a professional, or anyone who needs to calculate the volume of a pyramid, our calculator is designed to make your task easier and more enjoyable. With its user-friendly interface, accurate calculations, and comprehensive features, our volume of a pyramid calculator is the perfect tool for anyone looking to determine the volume of pyramids effortlessly and efficiently. In summary, our volume of a pyramid calculator is an invaluable tool that simplifies the process of calculating the volume of various types of pyramids. With its user-friendly interface, accurate calculations, support for multiple unit options, instantaneous results, and detailed step-by-step solutions, our calculator empowers users to solve pyramid-related problems with ease and confidence. Whether you're a student tackling geometry assignments, a professional working in architecture or engineering, or anyone curious about the volume of pyramids, our calculator is designed to meet your needs. Its accessibility on any device with an internet connection makes it a versatile tool that can be used anywhere, anytime. We believe that our volume of a pyramid calculator is a valuable addition to the educational and professional landscape. By providing accurate and reliable results, we hope to encourage a deeper understanding of pyramids and their properties. We also strive to make learning and problem-solving more enjoyable and engaging. In closing, we invite you to explore our volume of a pyramid calculator and experience the difference it can make in your learning or professional endeavors. With its comprehensive features and user-friendly design, our calculator is the perfect tool to help you determine the volume of pyramids accurately and efficiently.
Emotions can run high after a loved one dies, particularly if your family's assets include items with sentimental value, and the last thing you want is for your family to start fighting after you pass away. Defuse Conflict Over Sentimental Items Before You Pass Away How can you prevent your heirs from fighting over items with sentimental value? Many people believe that a statement in a will or trust that basically says "tangible personal property should be divided as my heirs see fit" will solve the problem. However, this can lead to a host of potential conflicts. A better approach is to put specific items that you believe are of interest to certain family members in writing, and then discuss your decisions in advance with your family. In this way, many emotionally charged disputes can be avoided. What if you are convinced that a former spouse, one of your children, Continue Reading... →Posts Tagged Wills Turning 18 is a big deal, not just from a parent's emotional perspective, but legally too. Eighteen is a magic birthday, a milestone into adulthood. At 18, your teen can vote, buy a house, or marry their high school sweetheart. They can also go to jail, get sued, and gamble away their college tuition in Vegas. In your eyes, your baby will always be "your baby," no matter their age, but in the eyes of the law, that "baby" is legally an adult on their 18th birthday. In New York State, a child is entitled to be financially supported by his or her parents until the age of 21, unless married, self-supporting or in the military; as far as the law is concerned, he or she is an adult at age 18 and information regarding their health, finances, and education will not be disclosed to anyone without their written consent. Continue Reading... →Another reason a will isn't enough is that the ownership of many assets transfers outside the will, including life insurance, annuities, retirement accounts like IRAs and 401(k)s, jointly-owned property and more. The beneficiary designations of these assets, not the will, determine how they will be distributed. Many IRS rulings and court cases have concluded that the owner's statements and intent in his or her will do not matter if they contradict what was written on the beneficiary designation form. This is why it is so important to review your beneficiary designations periodically to ensure they reflect your wishes now, not what you wanted when, for example, you opened the IRA 20 years ago. Many families utilize trusts in their estate plans. These provide a greater level of protection and flexibility than what a will alone can provide. For instance, a revocable living trust allows your estate to avoid probate entirely-and Continue Reading... →A will can help you accomplish a number of important planning goals. For instance, it allows you to control how your assets are distributed after you pass away. Without a will, your assets will be distributed according to what is known as intestate succession, in accordance with strict guidelines set by the state. What you "would have wanted" is irrelevant to the state. Your assets must be distributed, and the state has devised a formula to do so. A will also gives you control over how your minor children will be raised if something terrible happens to you and your spouse. Your will allows you to name people of your choosing-people you trust-to raise and care for your children if you cannot. Without a will, the court will decide who has control over your children. The court's decision could lead to your children being raised in a place and manner Continue Reading... →
United Launch Alliance (ULA) ignited its last Delta IV Heavy rocket to launch NROL-70, a classified payload for the U.S. National Reconnaissance Office (NRO). Related: Facts about ULA's Delta IV Heavy rocket ULA is retiring the Delta IV, and eventually its other legacy rocket, the Atlas V, in favor of its newly introduced Vulcan, which flew a near-perfect first mission in January. Go Delta In addition to being the 16th Delta IV Heavy, Tuesday's launch was also the 45th liftoff of a Delta IV, the 35th Delta IV to fly from Florida and the 389th Delta launch of any kind since 1960 (of which 294 were sent skyward from Cape Canaveral). Half of the Delta IV Heavy launches were devoted to sending NRO payloads into orbit. Originally flown by Boeing before the aerospace company partnered with Lockheed Martin to establish ULA, the Delta IV and Delta IV Heavy became the primary rocket supporting U.S. military payloads. At liftoff, the Delta IV Heavy generated 2.1 million pounds (9,341 kiloNewtons) of thrust, a significant increase over the 150,000 pounds (667 kiloNewtons) in 1960. Despite its long history, only a few Delta rockets are preserved by museums and rocket parks today. "We don't have an extra Delta IV Heavy to put in a museum," said Bruno. Following six decades of flights, Tuesday, April 9, saw the final Delta rocket launch, which resulted in a shift in how the U.S. S. places spacecraft, interplanetary missions, and satellites into Earth orbit. Launching NROL-70, a classified payload for the U.S., United Launch Alliance (ULA) ignited its final Delta IV Heavy rocket. s. The Office of National Reconnaissance (NRO). At 12:53 p.m., the potent booster left Space Launch Complex-37 (SLC-37) at the Cape Canaveral Space Force Station in Florida. me. EDT (1653 GMT), figuratively igniting itself for the sixteenth and last time. In a call with reporters on March 26, United Launch Alliance CEO Tory Bruno stated, "It is a bittersweet moment for us.". "It's an incredible technological marvel, standing 23 stories high, with a propellant capacity of one million gallons, a thrust of 2.5 million pounds, and the highest metal content of any rocket. It even lights up before it leaves the ground.". **. That sight, peculiar to the Delta IV in its heaviest configuration, resulted from hydrogen accumulating in the flame trench and then rising up alongside the rocket following its use in cooling the three RS-68A engines to cryogenic temperatures. Flares lapped at the orange insulation covering the core stage and its two side-mounted boosters as the engines fired, setting the hydrogen on fire. The reason for the dramatic display of a self-immolating rocket and the deliciously toasted marshmallow boosters before she flew up was explained by Bruno. About four minutes into the flight, the two boosters were discarded, and a minute and forty-five seconds later, the core, or first stage, separated. Then, the NROL-70 payload was launched into space by a single RL10C-2-1 engine on the Delta cryogenic second stage. After the fairing jettison occurred at roughly 6 minutes and 40 seconds into the flight, coverage of the launch was cut short due to concerns about national security. Related: Details on the ULA-built Delta IV Heavy rocket. The newly unveiled Vulcan rocket, which completed a nearly flawless first flight in January, is replacing ULA's Delta IV and eventually its other legacy rocket, the Atlas V. All of the long-range rockets' configurations were intended to be replaced by the Vulcan. Because national security space missions are our core and because of the special set of missions there, a high-energy launch vehicle is needed, this is a great mission to consider that transition. That's why we created Vulcan," Bruno said. Move, Delta. Aside from being the 16th Delta IV Heavy, Tuesday's launch was also the 45th Delta IV liftoff, the 35th Delta IV to take off from Florida, and the 389th Delta launch overall since 1960 (of which 294 were launched from Cape Canaveral). Enormous NRO payloads were launched into orbit during half of the Delta IV Heavy launches. Additionally, NASA, NOAA (the U.S. Oceanic and Atmospheric Administration), and other organizations received support from the rocket in its less potent configurations. S. The United States' National Oceanic and Atmospheric Administration. S. Commercial and Air Force payloads. The world's first passive communications satellite experiment was meant to be launched on May 13, 1960, but the Delta's attitude control thrusters failed to fire, making the first launch attempt unsuccessful. The vehicle was named the Thor-Delta because the Delta first operated as the second stage atop a Thor ballistic missile. ). Related: Get to know the United Launch Alliance's Delta Rocket Family. The first successful satellite transmission and two-way communications between two locations on Earth via space occurred three months later when the Thor-Delta launched Echo IA into orbit. The second weather satellite and Telstar-1, the latter of which enabled the first live transatlantic television feed, were launched in response to that success. Then came Delta B, a variation of the Thor-Delta, whose flights included launching Syncom-2, the first satellite into a geosynchronous orbit, in July 1963. Originally designed to carry NASA research satellites into orbit, Delta C was introduced four months after the launch of Syncom-2. The first geostationary communications satellite, Intelsat I, was launched in 1964 by the Delta D, which upgraded the Delta C configuration with three solid rocket motors. A year later, the Delta D launched the first commercial communication satellite. See also: Rocketry in history. NASA Pioneer probes were launched by Delta E to measure interplanetary phenomena from distant points in space. NASA launched a fleet of satellites carrying biological samples for research aboard Delta G (F was not built), which was essentially a Delta E without its third stage. Delta J made a single launch, K was never constructed, and L debuted an extended Thor first stage. Delta M and Delta N were utilized to send additional communications satellites into Earth orbit, completing the alphabetical designations. Next in line were the Delta 900, which in 1972 launched NASA's first LandSat meteorological satellite into orbit; Delta 2310, which launched Spain's first satellite into orbit to study the ionosphere; and Delta 2914, which launched the first NOAA Geostationary Operational Environmental Satellite (GOES). In order to reach higher orbits, Delta 3000 introduced the payload assist module (PAM). NASA's first rocket launch following the 1986 space shuttle disaster was a 3000-series rocket, but it was also doomed to fail and was destroyed before it could release the GOES satellite it was carrying. While only three rockets from the 4000- and one from the 5000-series were launched, they paved the way for the Lite and Heavy versions of the Delta II. The first GPS satellite to go into operation was launched in 1989, marking the introduction of the Delta II into service. Over the course of nearly 30 years, the Delta II took off 155 times in total, with all but two of those flights ending in success. NASA's payloads comprised one-third of the launches; these included the first mission to orbit Mercury, the first mission to land on an asteroid, the first mission to send eight robotic landers and rovers to Mars, and the first spacecraft to return a sample from a comet. Before launching with NASA's ICESat-2 Earth observation satellite for the final time in 2018, the Delta II also carried out the deployment of the Spitzer Space Telescope and the planet-hunting Kepler observatory. There were just three flights on Delta III. The final launch contained a dummy payload after the first two failed. The U.S. developed the Delta IV. s. the Evolved Expendable Launch Vehicle (EELV) program of the Air Force. The Delta IV and Delta IV Heavy, which were first flown by Boeing prior to the aerospace giant joining forces with Lockheed Martin to form ULA, were the main rockets supporting U.S. S. weaponry payloads. Additionally, NASA used the Delta IV Heavy to launch the Parker Solar Probe to "touch" the sun in 2018 and to launch the Orion spacecraft on its first unmanned Exploration Flight Test (EFT-1) in 2014. The Delta is visible. The Delta family of rockets developed and became increasingly powerful with each iteration and configuration. The iconic launch vehicle was equipped with larger tanks, strap-on solid rocket boosters, upgraded engines, and more potent upper stages in order to lift heavier payloads and propel them farther into space. With its Tuesday launch to conclude the program, the Delta IV Heavy was more than 2.5 times the height of the original Thor-Delta, standing at 235 feet (72 meters). A notable improvement over the 150,000 pounds (667 kiloNewtons) produced in 1960, the Delta IV Heavy's thrust at liftoff was 2.1 million pounds (9,341 kiloNewtons). It has accomplished tremendous things for our country and has a rich history. We're honored to have contributed to that," Bruno remarked. "And although Vulcan is the way of the future, I personally regret its departure. ". Not many Delta rockets remain in museums or rocket parks today, despite the rocket's long history. Thor-Delta and Delta II on display in the Rocket Garden of the Kennedy Space Center Visitor Complex in Florida. Goddard Space Flight Center, NASA, Greenbelt, Maryland, is home to another Thor-Delta. In 2007, the Air Force Space and Missile Museum (now known as the Cape Canaveral Space Force Museum) received the static fire unit that would eventually become the Delta IV common booster core. It was then put on display outdoors. Bruno remarked, "We don't have an extra Delta IV Heavy to put in a museum.". "There was definitely something unique about this last rocket.". **.
Brake checking is more than just an annoyance on the road; it is a reckless driving behavior that poses significant risks to road safety. This dangerous act involves a driver intentionally slamming on the brakes abruptly and unexpectedly in front of another vehicle, often as an aggressive gesture in response to perceived wrongdoing. As we delve into this topic, we will explore the potential dangers of brake checking and its illegality, understand the motivations behind it, and learn how drivers can avoid this hazardous practice to promote safer driving habits. For proper maintenance of the brakes of the car it is necessary to let the real experts take care of it. What is Brake Checking? Brake checking refers to the intentional act of abruptly and unexpectedly slamming on the brakes in front of another vehicle, often as an aggressive gesture in response to perceived wrongdoing. This action can lead to dangerous situations, including rear-end collisions and road rage incidents. It is essential to recognize that brake checking not only endangers the driver engaging in it but also puts the lives of other road users at serious risk. The Risks and Dangers The risks associated with brake checking cannot be overstated. When a driver suddenly decelerates without warning, it catches other drivers off guard, reducing their reaction time and increasing the likelihood of a rear-end collision. This type of collision can result in property damage, injuries, and even fatalities. Moreover, brake checking can escalate conflicts between drivers and lead to road rage incidents, further compromising road safety. While some drivers may view brake checking as a way to "teach a lesson" to another motorist, the reality is that such actions only perpetuate aggressive driving behaviors. Instead of creating a safer road environment, brake checking creates a chain reaction of dangerous maneuvers that can lead to a potentially catastrophic outcome. Factors that Motivate Brake Checking Understanding the motivations behind brake checking can shed light on the root causes of this aggressive driving behavior. Drivers who engage in brake checking are often motivated by feelings of frustration, anger, or a desire to assert dominance on the road. The anonymity of being inside a vehicle can contribute to a sense of detachment from other drivers, leading to impulsive and dangerous actions. In many cases, brake checking is an act of retaliation. Drivers may feel provoked by tailgating, aggressive lane changes, or other perceived infringements of their space on the road. Consequently, they resort to brake checking as a way to assert their frustration or to "punish" the other driver. However, this response is not only unsafe but also counterproductive in promoting responsible driving habits. How to Avoid Break Checking? To avoid engaging in break checking, drivers should adopt defensive driving techniques. Maintaining a safe following distance from the vehicle ahead provides ample time to react to sudden changes in speed, reducing the temptation to break check. Furthermore, staying calm in challenging driving situations and practicing patience can help prevent aggressive responses and promote safer driving habits. Drivers should also be aware of their emotional state while behind the wheel. If feeling stressed, angry, or fatigued, it is essential to recognize these emotions and take proactive measures to deescalate the situation. Deep breathing, playing calming music, or pulling over to take a short break can help regain composure and prevent impulsive actions. Promoting Safer Driving Habits Promoting a culture of safe and respectful driving is essential for a safer road environment. Encouraging responsible behavior, such as using turn signals, yielding right-of-way, and obeying traffic laws, can contribute to a more harmonious driving experience for everyone. Emphasizing the importance of treating fellow drivers with respect and consideration can foster a positive driving environment. In addition to individual responsibility, law enforcement plays a crucial role in promoting safer driving habits. Strict enforcement of traffic laws, including penalties for aggressive driving behaviors like break checking, can act as a deterrent. Public awareness campaigns that highlight the dangers of brake checking and its legal consequences can also educate drivers and encourage them to make safer choices. Legal Consequences in Canada In Canada, brake checking is not only a dangerous driving behavior but also illegal. "Is brake checking illegal?" Yes, authorities consider brake checking as aggressive driving, and those caught engaging in this behavior can face severe legal repercussions. Penalties vary by province but may include substantial fines, demerit points added to the driver's license, driver's license suspension, and even criminal charges in severe cases. Drivers must be aware of these consequences to deter them from engaging in such reckless behavior. Law enforcement agencies often conduct targeted initiatives to combat aggressive driving behaviors. These initiatives may involve increased presence on the roads, public awareness campaigns, and educational programs. By highlighting the legal consequences and the potential risks associated with brake checking, authorities aim to discourage drivers from engaging in such dangerous behaviors. Public Awareness and Educational Initiatives Efforts to combat brake checking and other aggressive driving behaviors often include public awareness campaigns and educational initiatives. Government agencies, law enforcement, and traffic safety organizations work together to inform drivers about the dangers of brake checking and the importance of responsible driving. These initiatives aim to raise awareness and encourage drivers to prioritize road safety and respect for fellow road users. Public awareness campaigns can take various forms, such as television advertisements, social media campaigns, and billboard displays. By reaching a broad audience, these campaigns strive to educate drivers on the potential risks of brake checking and promote a culture of safer driving. Brake checking is a dangerous and irresponsible driving behavior that jeopardizes road safety. By understanding the risks and consequences associated with brake checking and promoting responsible driving habits, we can work together to create a safer road environment for everyone in Canada. Choosing to drive courteously, calmly, and responsibly not only protects our own lives but also contributes to a positive and safer driving experience for all road users. Through a combination of individual responsibility.
Running a business can be time consuming, stressful and take a toll on the owner, their family, and too often, marriages. In fact, divorces are more common for business owners than in general, ranging between 43 and 48%†. Of particular concern to small business owners may be the dramatic increase in what some call 'gray divorce,' meaning couples that divorce at 50 or older. Gray divorces have roughly doubled since the 1990s‡. By the time they've reached their 50s and beyond, couples are likely to have accumulated significantly more assets than they had when they were just starting out. They have much more to lose in a divorce, including possibly the business that they've worked so hard to build. Divorce isn't a pleasant topic, but an important one to take into account when looking to the future. Discussing and agreeing on reasonable and fair terms and conditions during amicable times may lessen the tumult of divorce. Fortunately, there are steps for asset protection to take even before marriage to prepare for such an eventuality. Before "I do" Lay out terms before marriage A good first step is the often maligned and misunderstood prenuptial agreement–not a practice as rare as one may think, and certainly not limited to the rich and famous. A 2022 Harris Poll actually found 15% of those responding to a survey have signed prenuptial agreements designed for asset protection§. Often referred to as a 'prenup,' the topic may suggest one foresees doom, but like the need for life insurance, wills and trusts, preparing for any and all eventualities is a sign of wisdom–especially when significant assets may come into play. If both parties have relatively similar levels of wealth, the topic may be easier to discuss than if the wealth gap is substantial. A prenuptial agreement does not exclude one person from another's assets. It simply allows both parties to agree on how the assets, including investments and retirement funds, property, the business(es) and expected inheritances should be distributed if necessary. A prenuptial agreement can also protect one partner from another's debt, which could be a less confrontational angle to introduce the topic. It's important to note that each state has unique rules and that a legal professional can draft an effective agreement. When working together If only one spouse owns the business but both partners work in the business, there's a chance that courts may view the ownership of the business from an equitable standpoint. And the more involved each person is in the business, the more 'ownership' they'll each feel. You could protect your business in the case of divorce by forming an LLC, trust, or corporation even if you're the sole owner. This allows you to separate yourself as an individual from the business.
The Art of Change How do you handle change? The Art of Change provides timeless answers to this eternal question. It is a modern reading of The Book of Changes/I Ching — a guide for sustainable success in turbulent times. Discover solutions for your current situation by exploring relevant sections and considering how you can apply the change patterns in your context. All parts. The Art of Change is a reading of the classic Book of Changes (I Ching) using transformation, leadership and strategy glasses — seeing it as a practical guide for actions and decisions, consciously leaving out the fortune-telling parts. It is part of a trilogy — The Art of Change, The Art of Leadership and The Art of Strategy — exploring timeless patterns for sustainable success in turbulent times, helping us to think and act from first principles while being mindful of context. The Books of Changes has inspired a diverse set of people: If you use it long enough and continually enough, it will begin to change and shape you as a person. — Philip K. Dick, writerThe only thing that is amazingly true, period. — Bob Dylan, musician, poet and Nobel laureateThe primary source for the pragmatic mysticism of Lao Tzu's Tao Te Ching (The Art of Leadership) and the analytic strategy of Sun Tzu's Art of War (The Art of Strategy). — Thomas Cleary, writer and literary translatorThere is genuine value in relating this ancient text to the dilemmas of the modern business world. — John Minford, sinologist and literary translatorIt offers guidance for responding appropriately to shifting life conditions. — Ikujiro Nonaka and Zhichang Zhu, business strategists The Art of Change is an 8-part series that interprets 64 short sections on how to successfully create and respond to change in a volatile, uncertain, complex and ambiguous world where the rate of change is increasing daily. The interpretation gently transforms The Book of Changes — first written down around 1,200 BC in what is now called China and one of the world's most influential and enigmatic texts — into modern, crisp English. Through diverse situations and patterns, you will discover new perspectives on people and their behaviours, get actionable advice on handling and creating change strategically and effectively, and, thus, learn how to make a difference. You will also improve your understanding of China and Chinese ways of transforming, leading and strategising since The Book of Changes is deeply ingrained in Chinese thinking, decision-making and actions, e.g. as part of the civil servant education for over 2,000 years. Using this Book Each section includes helpful questions and commentary to complement and clarify the terse, poetic text, turning it into a conversation through the ages. An extensive Glossary is also provided since many Chinese concepts are purposefully abstract and ambiguous. I have kept the text as simple as possible but not simpler and recommend reading the sections slowly, in small doses, to give time for reflection. See it as a handy reference where you discover solutions for your current situation by exploring the relevant sections and then considering how you can apply the change patterns in your context. Here is a step-by-step guide: - Pick one or several sections that are relevant to your current situation. - Ponder the patterns in these sections and consider how they could be applied in your context. - Apply the change patterns: behave, act, decide. - Learn by observing the consequences of your behaviours, actions and decisions. - Repeat from step 1. Summary of the Book The following is a poetic summary of The Art of Change. The world moves in cycles: day follows night, sunshine after rain; in difficulty lies opportunity; success hides within failure. Expecting constant change means knowledge has limits. Yet, finding agency to decide and act through patterns and rituals. Using patterns to see pitfalls, perspectives, possibilities, turning failure into success. Stop, relax and breathe: reflecting on past, present, future; assessing carefully, then shaping or adapting. Harmonising competing conditions embracing fluidity, Balancing timely: patterns for this situation, suitable actions and decisions. Developing confidence to face and create change with courage, humility, resolve. Being fit for the future is being aware and alive in the unknown. Change is natural: following the line of least resistance, going with the flow, just like water does. On Change Cultures, nations, religions and people are not rocks. They are in constant transformation. — Hans Rosling, physician, academic, public speakerThe game is not better predicting the future, but better adapting to how the present is different from your expectations. We can drive ourselves crazy with expectation. But by preparing for every eventuality we can think of, we leave ourselves vulnerable to the eventualities we can't imagine. There is another way. The team can be perfectly prepared at any moment to go in whatever direction the business or the system demands. By giving up explicit preparation for change, paradoxically they become entirely prepared for any change. They expect nothing. They can no longer be surprised. — Kent Beck, programmer and creator of XP There is no one-size fits all solution but rather a dynamic mindset that adapts and evolves. It invites us to embrace change, question our assumptions, and continuously seek improvement. — Jim Highsmith, software engineer and creator of Adaptive Software DevelopmentHuman beings are amazingly adaptable. We are just enormously resilient as human beings. So, in many ways human beings already have the essential qualities that our organisations lack. — Gary Hamel, management professor and consultantWe got to change — come together. — James Brown, musician But how? Let's explore the eternal wisdom from The Book of Changes in this modern reading in the sections below. Acclaim for The Art of Change This is wonderful. — Frank ChiaroWell articulated. — Stefano RoncoroniI have read things that I needed to read — right now, in my life. As usual, the I Ching never fails. — Rod Leaverton, strategist The Art of Change: All Parts Pick section(s), ponder patterns, change, learn, repeat! Contents: A summary of all parts Introduction: Patterns for success - Sections 1–8: Turbulence, Flow, Growth, Learning, Waiting, Conflict, Competition, Collaboration - Sections 9–16: Nurturing, Mistakes, Balance, Obstruction, Fellowship, Power, Modesty, Excess - Sections 17–24: Following, Renewal, Attitude, Observing, Resistance, Image, Division, Cycles - Sections 25–32: Flowing, Capabilities, Nourishing, Overload, Danger, Knowledge, Resonance, Perseverance - Sections 33–40: Retreating, Strength, Progress, Darkness, Teamwork, Opposition, Difficulty, Removal - Sections 41–48: Decline, Surge, Determination, Alliances, Teaming, Rising, Adversity, Energising - Sections 49–56: Change, Renewing, Shock, Stillness, Development, Underdog, Success, Unknown - Sections 57–64: Influencing, Joy, Dispersal, Restraining, Integrity, Exceeding, Completion, Incomplete Glossary: Explanation of key terms Acknowledgements: Standing on the shoulders of giants Sources: Where to learn more Other reading formats This text is provided as Creative Commons Attribution-ShareAlike 4.0 International by the author, Erik Schön.
Is Intelligence Innate and Fixed? Given the recent James Watson "race and IQ" controversy, I took on to read Stephan Jay Gould's classic book The Mismeasure of Man, in which he debunks IQ (and the underlying "g") as measure of defined, innate, "intelligence". Fascinating reading overall, very technical in some areas. The key take-away? In the last chapter, A Positive Conclusion, he writes that - "Flexibility is the hallmark of human evolution…In other mammals, exploration, play and flexibility of behavior are qualities of juveniles, only rarely of adults. We retain not only the anatomical stamp stamp of childhood, but its mental flexibility as well…Humans are learning animals" He then relates this story from T.H. White's novel The Once and Future King - God, he recounts, created all animals as embryos and called each before his throne, offering them whatever additions to their anatomy they desired. All opted for specialized adult features-the lion for claws and sharp teeth, the deer for antlers and hoofs. The human embryo stepped forth last and said: Please God, I think that you made me in the shape which I now have for reasons best known to Yourselves and that it would be rude to change. If I am to have my choice, I will stay as I am. I will not alter any of the parts which you gave me…I will stay a defenceless embryo all my life, doing my best to make myself a few feeble implements out of the wood, iron, and the other materials which You have seen fit to put before me.." "Well done", exclaimed the Creator in delighted tone. "Here all you embryos, come here with your beaks and whatnots to look upon Our fist Man. He is the only one who has guessed Our riddle…As for you, Man…You will look like an embryo till they bury you, but all the others will be embryos before your might. Eternally undeveloped, you will always remain potential in Our image, able to see some of Our sorrows and to feel some of Our joys. We are partly sorry for you, Man, but partly hopeful. Run along then, and do your best" For related posts, you may enjoy Darwin's adult neuroplasticity, with a number of fascinating quotes, including - "Therefore my success as a man of science, whatever this may have amounted to, has been determined, as far as I can judge, by complex and diversified mental qualities and conditions. Of these, the most important have been–the love of science– unbounded patience in long reflecting over any subject–industry in observing and collecting facts–and a fair share of invention as well as of common sense. With such moderate abilities as I possess, it is truly surprising that I should have influenced to a considerable extent the belief of scientific men on some important points." And Richard Dawkins and Alfred Nobel: beyond nature and nurture - We have at least the mental equipment to foster our long-term selfish interests rather than merely our short-term ones…We have the power to defy the selfish genes of our birth and, if necessary, the selfish memes of our indoctrination. We can even discuss ways of deliberately cultivating and nurturing pure, disinterested altruism-something that has no place in nature, something that has never existed before in the whole history of the world. We are built as gene machine and cultured as meme machines, but we have the power to turn against our creators. We, alone on earth, can rebel against the tyranny of the selfish replicators." You guessed right. We are not big fans of the idea of intelligence as a fix, innate characteristic we are born with. Genes predispose us, but it is the combination of our environments and our actions that we better focus on. We also need to add better measures of, and training for, Flexibility, Adaptability, and Learning how to Learn, and a number of other cognitive abilities, to our view of "intelligence", so we can "evolve" faster in our lifetimes. Pic: credit to Dampfred, via Flickr 13 Comments Very good message, Alvaro! It's our mission to tell people that genes create phenotype just with the effect of the environment. Gould is almost on the verge of dishonesty with his book. If you are going to read his book, then you should at least read a good defense of Watson The link is here. Its terribly PC to say that genetics makes hardly any difference to IQ or IQ makes hardly any difference to, er anything. Great for getting readers attention and nods of agreement. Its also complete bollocks.Twin studies (and certainly any twins I know) as well as a simple glance at anyone I know shows and incredibly strong correlation between genetics and intelligence, personality and all sorts of other things such as skin colour and eye colour. Of course bias and overgeneralizations are common flaws in such research but that doesn't mean that they are automatically flawed in more fundamental ways. Nor does the fact that some might misinterpret it, make the base research flawed.I remember sitting in a class being taught about the bell curve while a group from a higher bell curve sniggered in front and I thought. Hmm — what curve you associate yourself with doesn't change your actual intelligence. probably worth a read of the for the critiques (and praises I guess) I accept that intelligence is not 100% determined by genes – anyone who says that is obviously not thinking since, for one thing, I could drink alcohol and take drugs until I was brain damaged or dead and I definitely wouldn't have the same IQ afterwards. But surely no one ever proposes that that would have no impact on my intelligence. Clearly it is a mixture of things. What appears to happen, though, is that someone will propose that a certain group has a higher average intelligence (Let us say, 'philosophers' have a higher average intelligence than 'ditch diggers' or 'people in Manhattan' have a higher average IQ than 'people in the middle of Texas'). Those groups that are maligned then kick back and insist that one can't say that. Rather less an argument that it isn't true and more one that you "just can't say it†because then you might try to use it for somthing. And one side debates with logic and the other with more of a 'aren't they disgusting and mean†sort of approach. (having siad that sometimes they are jsut plain racist ofcourse) Regarding the Flynn effect, I guess it depends on what you call intelligence. I read the Flynn effect according Flynn was explained by how we organize information — i.e. it didn't refer to a change in processing speed — just a change in the way the information being processed was organized. That's one theory anyway. It would seem however that as IQ tests get better it gets more constant (Of course we would discard a IQ methodology that got a less constant result!). But if for some reason one had to discard 'IQ†and instead use a new measure for 'g' I don't think people would be very worried. I note that I had an IQ test at a very young age and another reasonably recently both under proper test conditions – and got an identical result (yes not a single point of difference). Apparently the vast majority of my life and all that education made no difference at all. Regarding Crick I think that this triggers my racist bells "He went on to say that although he hopes all races are equally intelligent, "people who have to deal with black employees find this is not true."†But there could be a valuable piece of truth in "he is "inherently gloomy about the prospect of Africa†(although the truth might be dangerous, and if someone honestly says so I can respect that) Even if our intelligence happens to be absolutely identical across races – it won't be 'the same' on average (ie of exactly the same type). One model that seems to have some relation to reality is that people are most able to deal with capitalism in places where they have (as a genealogical line) had the longest exposure to money (again potentially dangerous but also implies that changes happen over 'short' period of time). For GNZ: "Regarding Crick I think that this triggers my racist bells "He went on to say that although he hopes all races are equally intelligent, "people who have to deal with black employees find this is not true."â€Â You meant Watson. (I have the same problem with Abbott and Costello.) woops appologies to Crick. You can talk openly about dogs without being politically incorrect. You won't get into trouble, lose your career or research grants, as you might if you reveal unpleasant truths about humans. All domestic dogs, from Chihuahua to Great Dane, are species canis familiaris; breed genetic differences result from enforced separations by breeders/trainers for the last 800 years. Domestic dogs are all one species. Similarly, all humans are species homo sapiens with race differences resulting from separation over thousands of years by geographic barriers. Dog breeds and human races are directly analogous as sub-groups within the respective species. Much can be learned from studying dogs; medical science does a great deal of this to avoid experimentation on humans. The brain is no exception, as dog brain structure and information flow processes are quite similar to that in humans. Numerous dog brain studies to analyze human brain diseases/conditions are in the medical literature.Any experienced dog breeder will acknowledge the profound influence of genetics on intelligence and behavior. Traits such as trainability, aggression, prey drive, docility, bite inhibition are highly heritable and difficult to modify. Extensive evaluations of dog intelligence have developed breed rankings according to ease of training (number of repetitions needed to learn a command) and reliability (percent of time) of correct response to learned commands. Instinctive ability to to take correct action in complex situations is also recognized to vary with breed (there is a valid reason police K‑9 units use German Shepherds instead of Pit Bulls). Among dog breeds, there is a huge Achievement_Gap, and it is GENETIC. This is all easily Googled… Humans are not exempt from the fundamental rules of biology. Rushton's publications (and James Watson's recent comments) are heavily-supported with mountains of peer-reviewed research by well-credentialed scholars; numerous key citations are available in two recent books: Hart "Understanding Human History" and Lynn "Race Differences in Intelligence." "1) No one is doubting the influence of genes. I agree with "Humans are not exempt from the fundamental rules of biology" 2) What you seem to be doubting is the influence of the environment. Why?" I know I'm really late to this, but you've got it backwards: there are literally no scientists who think/argue/hypothesize that intelligence is 100% genetic or hereditary. Being a "genetic determinist" in practice means that you think that somewhere between 1% and 99% (and, on average, more like 40% and 80%) of intelligence is hereditary. There are, on the other hand, quite a few who argue that intelligence is 0% genetic. As for Crick, it seems he was saved from being burnt at the stake by going off the scene early. " In brief I think it likely that more than half the difference between the average I.Q. of American whites and Negroes is due to genetic reasons, and will not be eliminated by any foreseeable change in the environment" would have gotten him the Watson treatment in 2007, to be sure. Anyway, it's rather amusing to read this and realize that, by Gould's definition, Alvaro is a genetic determinist. All that aside, we'd be better off if people stopped reading a 28 year old book by a paleontologist who wanted to advance the blank slate theory, creating a book that essentially everyone in the relevant field thinks is a pile of garbage. Go argue about twins studies, trans-racial adoption studies, etc, but leave Mr. "IQ tests 80 years ago were biased, so the entire field is junk!" out of it.
Greenville–Spartanburg Metropolitan Area \| \| Greenville–Spartanburg–Anderson, SC Combined Statistical Area \| \| Country \| United States \| State \| South Carolina \| Principal cities \| - Greenville - Spartanburg - Anderson - Mauldin - Easley - Clemson - Gaffney - Greer - Greenwood - Seneca \| Area \| \| • Total \| 6,168 sq mi (15,980 km2) \| • Land \| 6,008 sq mi (15,560 km2) \| • Water \| 141 sq mi (370 km2) 2.2% \| Population (2020) \| \| • CSA \| 1,487,610[1] (39th) \| Time zone \| UTC−5 (EST) \| • Summer (DST) \| UTC−4 (EDT) \| Area code \| 864 \| The Upstate, historically known as the Upcountry,[2] is a region of the U.S. state of South Carolina, comprising the northwesternmost area of the state. Although loosely defined among locals, the general definition includes the 10 counties of the commerce-rich I-85 corridor in the northwest corner of South Carolina. This definition coincided with the Greenville-Spartanburg-Anderson, SC Combined Statistical Area, as first defined by the Office of Management and Budget (OMB) in 2015. In 2023, the OMB issued its most updated definition of the CSA that coincides again with the 10-county region.[3] The region's population was 1,487,610 as of 2020. Situated between Atlanta and Charlotte, the Upstate is the geographical center of the Charlanta megaregion. After BMW's initial investment, foreign companies, including others from Germany, have a substantial presence in the Upstate; several large corporations have established regional, national, or continental headquarters in the area. Greenville is the largest city in the region with a population of 72,227 and an urban-area population of 387,271, and it is the base of most commercial activity. Spartanburg and Anderson are next in population. Ten counties are included in the Upstate of South Carolina: Greenville, Spartanburg, Anderson, Pickens, Oconee, Greenwood, Laurens, Cherokee, Union, Abbeville. County \| 2021 Estimate \| 2020 Census \| Change \| Greenville County \| 533,834 \| 525,534 \| +1.58% \| Spartanburg County \| 335,864 \| 327,997 \| +2.40% \| Anderson County \| 206,908 \| 203,718 \| +1.57% \| Pickens County \| 132,229 \| 131,404 \| +0.63% \| Oconee County \| 79,203 \| 78,607 \| +0.76% \| Greenwood County \| 69,241 \| 69,351 \| −0.16% \| Laurens County \| 67,803 \| 67,539 \| +0.39% \| Cherokee County \| 56,052 \| 56,216 \| −0.29% \| Union County \| 27,016 \| 27,244 \| −0.84% \| Abbeville County \| 24,299 \| 24,295 \| +0.02% \| Total \| 1,532,449 \| 1,511,905 \| +1.36% \| As of 2023, the Greenville–Spartanburg–Anderson CSA includes all ten counties in the Upstate. Within the CSA are a total of two metropolitan statistical areas and three micropolitan statistical areas.[3] As of the 2020 Census, the Greenville–Spartanburg–Anderson CSA had a population of 1,511,105. MSA \| County \| Population (2020)[4] \| Greenville–Anderson \| Greenville, Anderson, Pickens, Laurens \| 928,195 \| Spartanburg \| Spartanburg, Union \| 355,241 \| Total: \| 1,283,436 \| μSA \| County \| Population (2020)[5] \| Seneca \| Oconee \| 78,607 \| Greenwood \| Greenwood, Abbeville \| 93,646 \| Gaffney \| Cherokee \| 56,216 \| Total: \| 228,469 \| The following population rankings are based on the 2010 Census.[6] Greenville, Spartanburg, Anderson, Greer, Mauldin, and Greenwood, The OMB labels all these cities as principal cities in their respective MSAs and μSA.[3] Cities: Easley, Simpsonville CDPs: Taylors, Wade Hampton Cities: Clemson, Gaffney, and Fountain Inn, South Carolina. Gaffney is a principal city in its μSA. If students from Clemson University are included, Clemson has close to 30,000 residents. CDP's: Berea, Five Forks, Gantt, Parker, Boiling Springs Communities in the Upstate with under 10,000 residents include: Seneca is a principal city in its μSA. According to the 2010 Census, no town in the Upstate has a population greater than 6000. The following table shows the major institutions of higher education in the Upstate. In 2008, U.S. News ranked Furman as the 37th-best liberal arts college, Wofford College as the 59th-best, and Presbyterian College as the 101st-best.[citation needed] Also, they ranked Clemson University as the 67th-best national university.[citation needed] According to the Bob Jones University, its Museum and Gallery constitutes the largest collection of religious art in the Western Hemisphere.[7] The majority of business and commerce in the Upstate takes place in Greenville County. Greenville has the largest concentration of businesses and financial institutions in its downtown area. In fact, the Greenville-Spartanburg-Anderson MSA was ranked seventh in the nation by site consultants considering the top markets for economic development. Many financial institutions have regional offices located in downtown Greenville. These include Bank of America and the now-defunct Wachovia. Other major industries of commerce in the Upstate include the auto industry, which is concentrated mainly along the corridor between Greenville and Spartanburg around the BMW manufacturing facility in Greer. The other major industry in the Upstate is the healthcare and pharmaceuticals. Greenville Hospital System and Bon Secours St. Francis Health System are the area's largest in the healthcare sector, while the pharmaceutical corporation of Bausch & Lomb has set up regional operations alongside smaller recently developed local companies such as IRIX Manufacturing and Pharmaceutical Associates. The Upstate is also home to a large number of private-sector and university-based research including R&D facilities for Michelin, Fuji, and General Electric and research centers to support the automotive, life sciences, plastics, and photonics industries. Clemson University, BMW, IBM, Microsoft, and Michelin have combined their resources to create Clemson University International Center for Automotive Research, a research park that specializes in the development of automotive technology. These corporations have a major presence in the Upstate: Adidas, Advance America, Bank of America, BMW of North America, Bon Secours St. Francis Health System Bon Secours \| Bringing Health Care and Good Help to Those in Need, Bosch North America, Denny's Restaurants, Dunlop Sport, Ernst & Young, Fluor Corporation, Freightliner, GE Power Systems, Prisma Health [1], IBM, Kemet Corporation, Liberty Corporation, Spartanburg Regional Healthcare System, Michelin of North America, Microsoft, Milliken & Company, Spartanburg Regional Health System, Spectrum Communications, SunTrust, Ovation Brands, Perrigo Company of South Carolina, Techtronic Industries, Toronto-Dominion Bank, and Verizon. • BMW's only North American manufacturing plant is located in Spartanburg County, with an investment of $3.7 billion.[8] • Fujifilm located their first manufacturing facility in the U.S. in Greenwood County.[9] • Michelin North America's headquarters is located in Greenville, along with seven manufacturing plants, R&D facility, and test track located in the Upstate. Michelin employs more than 7,800 in South Carolina.[10] • Walgreens has their southeastern distribution center located in Anderson County, which employs mentally disabled workers as nearly 40% of their workforce.[11] The Upstate is served by two major interstate highways, I-85 and I-26. Other major interstate spurs include I-185, I-385, and I-585. The major airport in the region is Greenville-Spartanburg International Airport, located nearly halfway between Greenville and Spartanburg in suburban Greer. Greenville, Spartanburg, Anderson, Clemson, Pickens, Union, and Gaffney each have smaller airfields. Amtrak service along the Crescent Line stops in Spartanburg, Greenville, and Clemson. The Upstate region is served by three regional newspapers: The Greenville News, the (Spartanburg) Herald-Journal, and the Anderson Independent-Mail, each of which serves its individual city and surrounding area. The Post and Courier recently opened expansion newsrooms in Greenville and Spartanburg for coverage of the Upstate, including Clemson. The Upstate is part of the vastly larger Greenville-Spartanburg-Anderson-Asheville designated market area, which extends into western North Carolina and northeastern Georgia. These television stations serve the region:
Digital-Desert : Mojave Desert \| Visit us on Facebook -- Desert Gazette -- Desert Link \| Intro:: Nature:: Map:: Points of Interest:: Roads & Trails:: People & History:: Ghosts & Gold:: Communities:: BLOG:: Weather:: :?:: glossary \| Wildlife San Bernardino National Forest Silverwood Lake Wildlife & Habitats Wildlife such as California mule deer, gray foxes, and brush rabbits, western gray and ground squirrels, ringtailed cats, skunks, chipmunks and wood rats thrive here. Mountain lions, black bears, and occasional golden beavers may be sighted along the Mojave River. In bald eagles are occasionally seen gliding silently above the lake, fishing for their next meal. Water-oriented birds include great blue herons, snowy egrets, western grebes, Canada geese, mergansers and several varieties of ducks. Around Sawpit Canyon, birds of prey include redtailed hawks, Cooper�s hawks, ospreys and roadrunners. This is also home to Clark�s nutcrackers, Steller�s and scrub jays, rock wrens and mountain bluebirds. For more information on this ecosection in general see: Southern California Mountains and Valleys More specifically; Mountain subsections, Desert subsection, \| Intro:: Nature:: Map:: Points of Interest:: Roads & Trails:: People & History:: Ghosts & Gold:: Communities:: BLOG:: Weather:: :?:: glossary \| Country Life Realty Wrightwood, Ca. \| Mountain Hardware Wrightwood, Ca. \| Canyon Cartography \| DesertLink Links to Desert Museums \| Grizzly Cafe Family Dining \| Abraxas Engineering privacy \| These items are historical in scope and are intended for educational purposes only; they are not meant as an aid for travel planning. Copyright ©Walter Feller. 1995-2023 - All rights reserved. \|
The Evolution of Marriage Vows in Modern Nigeria Last Updated on January 28, 2024 The evolution of marriage vows in modern Nigeria holds immense significance in Nigerian culture. These vows have evolved over time, reflecting the changing values and beliefs of the society. They shape the foundation of marital bonds and serve as a public declaration of commitment and love. Delving deeper into this intriguing subject, we uncover fascinating insights into the rich history and cultural tapestry of Nigerian marriages. Join us on this captivating journey through time and witness the transformation of marriage vows like never before. Traditional Marriage Vows in Nigeria Marriage in Nigeria is a profound cultural institution, woven with rich traditions and ceremonies that have evolved over centuries. The heart of these nuptial traditions lies in the exchange of vows, a practice deeply rooted in the nation's diverse ethnic groups. A. Traditional Marriage Vows in Nigeria's Past In the past, traditional marriage vows in Nigeria were sacred and symbolic. They symbolized unity, love, and respect, binding not only the couple but their families and communities. These vows were recited in native languages, making them more intimate and culturally significant. B. The Importance of Traditional Vows in Nigerian Culture These vows hold immense importance in Nigerian culture and society. They serve as a pledge to honor one's heritage, uphold family values, and respect marital commitments. Traditional vows also act as a reminder of the couple's responsibilities in the community. C. Examples of Traditional Marriage Vows by Ethnic Groups - Yoruba: "Iyawo, I promise to love, cherish, and protect you. I will be your strength and your companion, now and forever." - Igbo: "Nne, Nna, I vow to stand by you in good and bad times, to provide, and to hold you dear till eternity." - Hausa: "Barka da zuwa gare ku, Ina son ku. Za mu taimaka mu yi baki daya. Insha Allah, I am yours." These are just a few examples, and there are countless variations depending on local customs. D. The Role of Religion in Shaping Traditional Marriage Vows Religion plays a significant role in shaping these vows. In predominantly Christian areas, vows may include references to the Bible, while Islamic regions incorporate verses from the Quran. These religious touches add a spiritual dimension to the promises, emphasizing divine blessings and guidance in the marital journey. In a nutshell, traditional marriage vows in Nigeria are a testament to the country's rich and diverse cultural heritage. They are more than words; they are promises deeply rooted in history, tradition, and spirituality. These vows continue to evolve, adapting to the modern world while remaining a cornerstone of Nigerian society, connecting generations and preserving a beautiful tapestry of tradition. Read: Incorporating Personal Touches in Your Marriage Vows Influence of Western Culture on Marriage Vows A. Western Influence Western culture has left an indelible mark on marriage vows in modern Nigeria. Globalization and increased exposure to Western traditions have reshaped the way Nigerians pledge their love. B. The Popularity of Western-Style Weddings Western-style weddings and vows are gaining popularity, reflecting a fusion of cultures. Many couples now opt for a mix of Western and traditional Nigerian ceremonies. C. Changes in Vow Language, Content, and Format - Language: English has become the primary language for vows. It's often preferred for its universality. - Content: Traditional vows emphasized commitment and respect; Western vows focus on love, partnership, and personal promises. - Format: Western-style vows are usually shorter, more personal, and often follow the "I do" structure. D. Examples of Western-Inspired Marriage Vows - "I promise to stand by you in sickness and health, to love and cherish you all the days of my life." - "I take you to be my lawfully wedded wife/husband, to have and to hold from this day forward." - "With this ring, I thee wed, and all my worldly goods I share." Basically, the influence of Western culture on marriage vows in Nigeria is a testament to the evolving nature of traditions. This fusion of cultures represents a beautiful blend of old and new, creating a unique and meaningful experience for Nigerian couples as they embark on their journey of love and commitment. Read: Bridging Cultural Gaps: Counseling for Inter-Tribal Marriages Incorporation of Personalized Vows In recent years, there has been a notable trend in Nigeria where couples are incorporating personalized vows into their wedding ceremonies. This shift in wedding traditions reflects a broader global movement towards individualism and self-expression in matrimony. A. Exploring the Trend - Expressing Unique Stories: Couples now seize the opportunity to tell their unique love stories. They describe how they met, their journey, and the deep emotions that bind them together. - Embracing Cultural Diversity: Nigeria's diverse ethnic groups bring a rich tapestry of traditions, which are now weaved into personalized vows. These vows often reflect the cultural roots of the couple, making the ceremony richer in tradition. - Encouraging Emotional Connection: Personalized vows allow couples to express their deep emotional connection and commitment. This authenticity brings sincerity and depth to the ceremony. B. Reasons Behind the Shift - Individualism: The trend towards personalized vows in Nigeria aligns with a growing sense of individualism. Couples want their wedding ceremonies to reflect their unique personalities and experiences. - Self-Expression: In a rapidly changing world, the desire for self-expression is becoming more pronounced. Personalized vows provide a platform for couples to express their love in their own words. - Modern Communication: The digital age has changed how we communicate, making it easier for couples to share their vows with a wider audience. Social media has played a significant role in this trend. C. Examples of Personalized Vows - Ada and Emeka: Ada, of the Igbo ethnic group, spoke of their love's journey, from a chance meeting at a cultural festival to the deep bond they've built. Emeka, a Yoruba, added verses in his native tongue to honor their cultural diversity. - Amina and Abdul: Amina, a Muslim, and Abdul, a Christian, incorporated verses from both the Quran and the Bible, symbolizing their interfaith union. Their vows underscored the message of love transcending religious boundaries. Significance in Modern Nigerian Weddings The incorporation of personalized vows into Nigerian weddings enhances the depth and individuality of the ceremonies. These vows offer a glimpse into the couple's love story and their shared vision for the future. They also embrace Nigeria's rich cultural tapestry and showcase the couple's commitment to forging a unique, enduring bond in a rapidly changing world. In essence, the shift towards personalized vows in Nigeria signifies a beautiful evolution in the country's wedding traditions. It's a testament to the enduring power of love and the importance of expressing it in one's own words. Read: Marriage Life: Tips for Harmonious Living in Nigeria The Role of Social Media and Technology A. Impact of Social Media and Technology In modern Nigeria, the evolution of marriage vows is profoundly influenced by social media and technology. Couples now have access to a vast array of vows, thanks to the internet's treasure trove of cultural diversity. B. Personalization of Vows They can seamlessly craft and personalize their vows, blending traditions from different cultures. This fusion results in uniquely tailored expressions of love and commitment. C. Showcasing on Social Media Social media platforms, such as Instagram and Pinterest, have become powerful tools for showcasing these creative marriage vows. Couples share their special moments, inspiring others and fostering a sense of community. D. Pros and Cons of Technology However, while technology enhances the vow creation process, it comes with pros and cons. - Accessibility: Couples can easily access a wide variety of vow samples and templates. - Inspiration: Technology serves as a wellspring of inspiration, helping couples find the perfect words. - Documentation: Digital vows can be easily stored, ensuring they're never lost. - Authenticity: There's a risk of vows feeling less authentic when borrowed from the internet. - Overwhelm: The sheer volume of choices can be overwhelming, making it challenging to select the right vows. - Privacy: Sharing intimate vows on social media can jeopardize privacy. All in all, social media and technology have revolutionized the crafting and sharing of marriage vows in Nigeria. Couples now have a wealth of resources at their fingertips, making it easier than ever to create vows that reflect their unique love stories. While technology offers incredible benefits, it's essential for couples to strike a balance between the virtual and the real to ensure their vows remain deeply personal and intimate. Read: Addressing Common Marital Issues in the Nigerian Context Learn More: Celebrating Love: Stories Behind Famous Nigerian Toasts The evolution of marriage vows in modern Nigeria reflects the changing societal norms and values. The traditional vows have gradually been adapted to reflect individuality, commitment, and equality within marriages. This shift in marriage vows has had a significant impact on the institution of marriage in Nigeria. It has allowed couples to express their love and commitment in their own unique way, while still preserving the cultural and emotional aspects of Nigerian weddings. Furthermore, this evolution of marriage vows prompts us to reflect on our own views and experiences with marriage vows. It challenges us to consider the meaning and significance we attribute to these promises and how they shape our relationships. As we explore the changing landscape of marriage vows, it is important for each individual to embrace their own values and beliefs. Whether traditional or modern, marriage vows hold a profound significance in the union of two individuals and should be approached with thoughtfulness and sincerity. Therefore, the continued preservation and adaptation of marriage vows in modern Nigeria is vital in maintaining the cultural and emotional essence of Nigerian weddings. It is through these vows that couples, families, and communities come together to celebrate love, commitment, and unity. So, what does your marriage vow mean to you?
As the summer practices and band camps are wrapping up, it is time to implement the show plan and make it come to life. The band director and staff must do careful planning well in advance, whether it is a football band performing three shows for the season or a complex, custom designed show for a competition band. This article is an excerpt from the show planning chapter of The Dynamic Marching Band. Some of the topics addressed are pertinent to the initial planning and choices made when creating a show. 1. Published vs. custom arrangements 2. Music and theme selection 3. Effective music repertoire in a nutshell 4. Creating a show 5. Story board 6. Data Module Sheet 7. Timeline 8. Visual considerations 9. Small band considerations Now is the time to review the plan and make sure everything is working together for a successful performance. Quality Music Arrangements Regardless of the source, quality arrangements should meet the following standards: • Interesting melodies, countermelodies, harmonies and rhythms • Variety of orchestration techniques • Dynamics and shaping clearly marked for every phrase • Articulations for every note clearly marked or indicated • Music should have direction, builds, impacts, tension and release • Key centers utilized for resonance of the wind instruments, particularly at impacts • Music selected should be challenging but achievable by the middle of the season • Questions for analyzing your show now that it is "on the field" • Are all of the above criteria "on the way" to being realized by the students? • Are edits or rewrites needed? (e.g. melodies are often lost on the field because of staging of the melody & accompaniment groups. Thin out the accompaniment and/or boost the melody.) • Did the arranger mark dynamics, articulations, etc.? If not, have the students mark them ASAP. Most students are visual dominant learners. • Is the music too difficult for the majority of the students? If it is, they will never be able to perform with confidence. If you know NOW, then make the edits NOW to give the students a successful experience. The Visual Component With a solid musical foundation established, the show must also work well as a visual production. The visual caption is often out of the band director's area of expertise and therefore, the color guard and visual specialist must be consulted to be sure the show lends itself well to a visual production. The visual elements—drill, color guard, marching and body movement—should interpret and enhance the music. The most effective shows have a blended and coordinated musical and visual program. Other visual considerations concern possible use of props, color guard costumes and flag designs. The color guard is an important element of the successful marching band. Now is the time to evaluate how well the color guard is contributing to the total band production. Is the choreography, equipment work and movement enhancing and interpretive to the music production? The guard is typically the last group to be able to write & learn their program which must be done after the drill and music program are designed. Are they progressing and achieving at an appropriate level? Ballads are inherently difficult visually because the tempo is slow and there is less motion. Bands often march very slow tempos to the eighth note pulse to achieve more visual interest. Care must be taken to maintain a smooth technique that is not distracting to the music played. Usually a difficult music passage needs to be played at a halt in order to achieve a strong performance. In such cases a body pose, or some body movement can visually enhance the effect of the moment. Be careful that the body movement does not impair good music performance. Visual and Music General Effect There needs to be an effect or applause point every 20–30 seconds in the show. It can be a "stand up and shout" moment or it can be a beautiful phrase that "takes your breath away," but it must be something —musical or visual—that makes the audience react. Every few minutes (2 or 3 times in a show) there needs to be a very big "Wow" moment that is memorable. The most effective moments in a show are a combination of music and visual. Theme and Show Title If there is a theme and show title, take a look (and listen) as the show is performed and ask some questions. Is the theme and show title obvious to the average fan in the stands (the popcorn eaters?) This is important for the football band as well as the competition band. No audience member (or judge) wants to watch a show and wonder "what was that all about?" What can be added or emphasized, musically and/or visually, to make the show more effective? It does not need to be hugely complex, in fact it is better if it is not! A simple prop or a short narration may be all you need. Enjoy Your Marching Band Season! This is VERY important for the students and staff. Make it happen! Wayne Markworth is the author of The Dynamic Marching Band, a textbook on marching band techniques. He was director of bands at Centerville High School in Ohio for 35 years and developed the marching band, known as "The Centerville Jazz Band." He received music education degrees from Indiana University and Northwestern University. In 2007, he was inducted into the Bands of America Hall of Fame.
AG Society News Wombat Watch: Week 3 The fires have not just devastated the animal population – they have also affected the environment in which they live. Exotic grasses and weeds are beginning to shoot up in place of the native grasses necessary for the wombat's survival. Small wombats, like Wombalano and her sisters, can be harmed by these exotic plants which can be toxic to the wombat's system. Students at the Darraweit Guim Primary School…
click below click below Normal Size Small Size show me how Preperation for science vocab test Question \| Answer \| adjacent \| having a common endpoint or border; next to \| approach \| to move or become near or nearer to something or someone \| assert \| to state something in a strong or definite way \| assume \| to think that something is true but not nowing for sure \| chapter \| one of the main sections of a book \| complicated \| hard to understand \| concept \| an idea of what something \| comprehend \| to aunderstand something well \| consist \| to be composed or made up of \| consult \| to talk about something with someone in order to make a descision \| contribute \| to give time, money, or goods to an organization \| criteria \| something that is ued as a reason to makea judgement or descision \| define \| to explain the meaing of a word, phrase, etc \| derive \| to hae something as a source; to come from something \| devote \| to commit a solemn act \| distort \| to make and object or sound different in a way that generally in unpleasing \| empirical \| originationg in or based on observation or experience \| environment \| conditions that surround someone or something that influence or affect the growth, health, progress, etc., of something \| establish \| to cause something to be widely known or acctepted \| expand \| to increase in size range, or amount; to become bigger \| feasible \| possible to do \| formulate \| to put in a systemized statement or expression \| guarantee \| to make a promise that whatever you are selling, doing, etc.,is what you say it is \| ignore \| to refuse to show that you hear or see something or someone \| implicit \| understood even though it in not clearly stated \| individual \| The only person in a group; the only member of a group \| intense \| having or showing characteristics in an extreme degree \| involve \| to have or include someone or something as a part of something \| magnitude \| the size, extent, or importance of something \| mathematics \| the science and relationships between numbers, quantities, and shapes \| modify \| to change the parts of something while not changing other parts \| shift \| to move or cause something or someone to move to different place, position, etc. \| simultaneous \| happening, or existing at the same time; exact coincidence \| specify \| to name or state explicitly in detail \| status \| The rank someone has in a society, group, or organization that determines the amount of power they have \| suffice \| to be or provide as much as needed \| technique \| a way of doing something by use of specia knowledge or skill \| theory \| an idea or set of ideas that is intended to explain facts or events \| transmit \| to send information, sound, etc. in the form of signals to a radio or television, computer, etc \| usage \| the way something is to be used properly \| verbal \| relating to speaking in words in any language \| obtain \| to gain or attain usually by planned action or effort \| passive \| acted upon by external energy; receptive to outside impressions or influences. \| pertinent \| related to the thing that is being thought about or discussed \| portion \| a part of something that is shared with other people \| precede \| to be, go, or come ahead or in front of \| prime \| the earliest stage; the chief or best individual or part \| publish \| to produce or release for distribution \| range \| a series of numbers including the highest and lowest possible amounts \| respective \| belonging or relating to each one of the people or things that have been mentioned \| role \| a part that someone or something has in a particular activity or situation \| select \| chosen from a group to include the best people or things \|
The system provides real-time information and has been developed with the support of the Center for Mathematical Modeling of the University of Chile (CMM) and financed by the EUROCLIMA Program. The Economic Commission for Latin America and the Caribbean (ECLAC) has made available the Greenhouse Gas (GHG) Satellite Monitoring System, a free access web portal that aims to "facilitate coherence and ambition between policies and results, by providing real-time information" on trends in GHG concentrations and CO2 emissions. The system provides information on trends in GHG concentrations and CO2 flows in Latin American countries, their main cities, and subregions, and has been developed by ECLAC's Sustainable Development and Human Settlements Division with the support of the Center for Mathematical Modeling of the University of Chile (CMM), financed by the EUROCLIMA Program. The System operates with information provided by Low Earth Orbiting Satellites (LEOs), which allows monitoring those gases regulated by the United Nations Framework Convention on Climate Change: Carbon Dioxide (CO2), Methane (CH4) and Nitrogen Dioxide (NO2). But it also monitors six other atmospheric pollutant gases: Total Ozone (O3), Tropospheric Ozone (O3), Aerosols (AI), Sulfur Dioxide (SO 2), Carbon Monoxide (CO) and Formaldehyde (HCHO). The portal allows to request a report by selected gas, city, country, or for Latin American regions of interest to users, allowing also to filter by a range of dates. All this information can be downloaded in PDF format or the point file (raster) to be entered into the GIS application (ArcGIS, QGIS, etc.), in GeoTIFF format. This system is an input that allows States to "compare the results of climate policy and changes action in the trajectories of CO2 emissions, and of policies to mitigate the pollution of other gases and particles of local interest, on the territory". Interested parties can access the CO2 Emissions Monitoring System here and the Greenhouse Gas Concentration Monitoring System, and other gases and particles, here. More information at the following link: https://www.cepal.org/en/subtopics/climate-change/satellite-monitoring-system-greenhouse-gases-ghg
Food is a big factor in dwelling a long, healthy life, and tons of Americans are eating diets that are harmful to their total well being. The District's Supplemental Nutrition Assistance Program helps residents buy the food they want. Eligibility and minimal advantages for this system have been expanded. If you assume you might be eligible for SNAP advantages, you'll be able to complete and submit an software by way of the DC Department of Human Services . DHS has a mixed software for public benefits, so you can apply for SNAP, Temporary Assistance for Needy Families , and Medical Assistance with the same software. The District's Supplemental Nutrition Assistance Program for Women, Infants, and Children helps pregnant girls, new mothers, infants, and children as a lot as age 5 buy healthy food and receive vitamin and breastfeeding counseling. Agricultural producers typically bear the burden of governments' need to keep food prices sufficiently low for rising city populations. Low costs for shoppers is often a disincentive for farmers to supply extra food, usually resulting in hunger, poor trade prospects, and an increased need for food imports. The UN's Sustainable Development Goal Target 12.3 seeks to "halve world per capita food waste at the retail and consumer ranges and reduce food losses along production and supply chains, together with post-harvest losses" by 2030. Climate change mitigation strategies prominently function lowering food waste. This may be so easy as a butcher making ready meat, or as complex as a modern worldwide food industry. Making Protein More Accessible: Arla Foods Elements Ceo Flags R&d Capabilities Amid Center Launch There are many cultures around the world by which individuals could not eat their meals from a plate. Although our translations of this guide preserve the single-plate graphic, we encourage its use for creating wholesome, balanced meals in context of cultural and individual customs and preferences. The Healthy Eating Plate encourages consumers to make use of healthy oils, and it doesn't set a maximum on the percentage of calories folks should get each day from healthy sources of fats. In this way, the Healthy Eating Plate recommends the opposite of the low-fat message promoted for decades by the USDA. Contribute your presents of food, time and money to make a difference right now. A month-to-month update full of vitamin information and tips from Harvard experts—all designed that can help you eat healthier. The contents of this website are for instructional purposes and are not intended to supply private medical recommendation. You should seek the recommendation of your physician or other qualified well being provider with any questions you would possibly have concerning a medical situation. Never disregard professional medical advice or delay in in search of it due to one thing you might have read on this web site. Fda Awards 11 Grants To Clinical Trials To Develop New Medical Merchandise For Uncommon Illness Treatments Urbanization and adjustments in consumer habits, including travel, have increased the number of individuals shopping for and eating food prepared in public places. Globalization has triggered growing client demand for a greater variety of meals, leading to an more and more complex and longer world food chain. Safe food provides help nationwide economies, trade and tourism, contribute to food and nutrition safety, and underpin sustainable development. This amounts to about 1.three billion tons of wasted food per year, price roughly $1 trillion. According to the UN, from 12 international locations with the very best prevalence of inadequate food consumption on the earth, 9 are in Africa. Indoor Air High Quality Options For Small Spaces More shops are offering delivery and curbside pickup and there are several different resources on this web page. Households participating in SNAP and the Temporary Assistance for Needy Families program will receive advantages on their existing EBT card. Eligible families without an EBT card will receive advantages on a brand new card that might be mailed to them. It's finest to get testing by way of your supplier, but if you have to use public testing, it can save you time in line by visiting coronavirus.dc.gov/register to create a profile from your smartphone, tablet, or computer. We're dedicated to serving to nations prevent the following zoonotic disease from turning right into a pandemic and be better prepared when dangers materialize. InHaiti, theResilient Productive Landscape projectmobilized emergency funding to assist over sixteen,000 farmers access seeds and fertilizer and safeguard manufacturing for the following two cropping seasons.
The Mark Review (formerly The Hip Hook) TLDR: Discover how the Hip Hook targets the iliacus muscle and provides relief for hip, back, and knee pains. Dec 30 2023 📍 Article Source Introduction to the Hip Hook The Hip Hook is designed specifically to target and release the tight iliacus muscle, a key muscle alongside the psoas that aids in leg movement. Tightness in the iliacus can stem from various activities like sitting for extended periods, running, or engaging in hip-opening movements during sports or workouts. Benefits of the Hip Hook This innovative tool not only aids in freeing up the core but also focuses on targeting the psoas muscle. It comes with a fabric drawstring pouch and an instruction manual for convenient use. By relieving tension in the core, the Hip Hook offers significant relief for individuals with tight iliacus muscles. Identifying a Tight Iliacus Visual cues like ankle balance and standing posture can indicate a tight iliacus. Other signs include discomfort inside the hip bones and one foot rotating outward more than the other. Locating the psoas is crucial for effective use of the Hip Hook, as it targets this area specifically. Methods of Using the Hip Hook The Hip Hook provides three different methodologies for usage, catering to varying comfort levels. From the doorway method for beginners to the roll-on technique for releasing tension, each approach offers unique benefits. By leaning into the tool or laying flat on it, users can experience relief in the hips, back, and knees. Value and Conclusion Despite a learning curve for positioning, the Hip Hook's ability to save on therapy costs in the long run makes it a worthwhile investment. While the initial price may seem steep, the relief and benefits it provides once mastered are invaluable. Timestamped Summary The Hip Hook is designed to target and release the tight iliacus muscle. - The iliacus muscle, along with the psoas, plays a primary role in lifting and moving the leg. - The tightness in the iliacus can develop from various activities such as sitting for long periods, running, lunging, playing sports, heavy lifting, and other hip-opening movements. The Hip Hook is a tool to free up your core and target the psoas. - Comes with a fabric drawstring pouch and an instruction manual. - The tool is designed with a non-slip surface and a focus on targeting the psoas. Hip Hook provides relief for iliacus muscles. - The device can relieve tension in the core and help those with tight iliacus muscles. - Visual cues and tests can indicate if one has a tight iliacus, such as ankle balance and standing posture. Signs of a tight iliacus - Tight and uncomfortable area inside the hip bones may indicate a tight iliacus - One foot rotating outward more than the other may indicate a tight iliacus Properly locate your psoas and start using the hip hook - Locate the anterior superior iliac spine (ASIS) and then find the psoas about an inch in from that. - Another tip is to go from your nipples straight down to locate the same point. - Hip hook has three different suggested methodologies for use. Doorway method for using the hip hook - This method is suitable for those nervous about putting full body weight, or with more tissue uncertainty - Place the hook against the door frame, lean into it, gradually applying pressure for release of psoas and iliacus Try the roll-on method for releasing tension in your psoas and iliacus muscles. - Place the hip hook on the psoas and slowly roll onto the device on a flat surface. Relax for about 30 seconds. - After easing up, drop your arm onto the hip hook to target the iliacus and relax for another 30 seconds. Different methods of using the hip hook for relief - Leaning into it for 60-90 seconds to feel relief - Laying flat on the hip hook to release the psoas and iliacus The Hip Hook provides relief for hip, back, and knee pains. - The price may seem high, but it can save on therapy costs in the long run. - It has a learning curve for positioning, but provides significant relief once mastered.
Project Based Learning Twin Peaks K-8 School offers Project Based Learning (PBL) opportunities for all students. PBL is a teaching method in which students learn by actively engaging in real-world and personally meaningful projects. PBL inspires a love of learning and gives students a personal connection to their academic experience. Teachers have been trained in PBL Works and offer at least one full gold-standard PBL unit for each year of schooling.
Importance of Communication in Relationships Relationships are unique in that they come in all shapes and sizes, and no two relationships are exactly the same. However, one major aspect of all relationships that is vital is effective communication. Communication plays a crucial role in our interactions with others, especially in our relationships. When it comes to communication in relationships, misunderstandings are one of the most common problems that arise. Whether it is a disagreement, argument, irritation, or difference of opinion, miscommunication can lead to significant problems in any relationship. It is essential in all relationships that we take time to communicate effectively and that we make a commitment to proactive communication. Relationship Misunderstandings Relationship misunderstandings can happen in many ways; it can be a result of not listening carefully, not asking the right questions, or not being clear about our intentions. In a relationship, misunderstandings can cause disagreements, arguments, irritation, hurt feelings, and even breakups. Misunderstandings can be small, like a misinterpreted text message, or significant, like a disagreement about a big life decision. Either way, misunderstanding can lead to negative emotions and can be detrimental to any relationship. Proactive Communication Proactive communication is essential in any relationship. It involves making time to meet with our partner, asking questions, and engaging in a dialogue to understand each other better. Proactive communication is not just about talking; it's also about listening. Listening actively is just as crucial as speaking clearly. It means paying attention, avoiding distractions, and asking questions to ensure mutual understanding. Proactive communication is about getting on the same page and avoiding misunderstandings. Relationship Questions for Couples Communication is the key to any healthy relationship. Whether you're in a new relationship or one that's been going on for years, it can be helpful to ask your partner the right questions to build a strong foundation. Here are some relationship questions for her, relationship questions for him, new relationship questions, and long-distance relationship questions. Relationship Questions for Her 1. What is your love language, and how can I best show you love and affection? 2. How can we best deal with disagreements or differences of opinion? 3. What habits do I have that you don't particularly like, and how can I work to improve them? 4. What sort of physical touch do you find most comforting or enjoyable? 5. How can we balance our work/personal lives and prioritize our relationship? 6. How can we work together to parent our children effectively? Relationship Questions for Him 1. Are you getting the necessary alone time you need, and how can we balance that with our time together? 2. How can we ensure that our intimacy and sex life remains fulfilling and exciting? 3. What are your financial goals, and how can we work together to achieve them? 4. How have your past experiences shaped you, and how can we work together to continue growing? 5. How can we rebuild trust if there has been infidelity in our relationship? New Relationship Questions 1. What are your interests, and how can we share them together? 2. What is your comfort level with communication, and how can we establish our communication style in our relationship? 3. How can we build each other's confidence and sense of security in this new relationship? 4. How can we avoid letting jealousy impact our relationship? 5. How vulnerable are we willing to be in this relationship, and how can we establish a safe space for vulnerability? Long Distance Relationship Questions 1. How can we best prepare for the time when we will finally close the distance? 2. What commitments are we willing to make to ensure that we see each other as often as possible? 3. How can we prepare for potential conflicts or misunderstandings that may arise due to distance? 4. How vulnerable are we willing to be in this relationship, and how can we establish a safe space for vulnerability? Communication is the key to any healthy relationship. By asking the right questions and engaging in open and honest communication, we can build stronger relationships and avoid misunderstandings. It's important to remember that communication is not just about talking; it's also about actively listening to our partners, paying attention to their needs, and demonstrating that we care. By making proactive communication a priority in our relationships, we can maintain healthy and happy relationships that last a lifetime. Building and maintaining a strong relationship takes work, but it's worth the effort. Whether you're in a new relationship or one that's been going on for years, its essential to consciously prioritize your relationship. In this article, we'll explore some of the challenges that couples may face and provide tips on how to overcome them to build a healthy and lasting relationship. Letting Go of Turf Compromise and acceptance are essential in any relationship. No one gets their way all the time, and both partners need to make an effort to meet in the middle. It's important to understand that we can't always get what we want and that our partner's emotional protection cannot be neglected. Letting go of our own turf to make space for our partner plays a significant role in creating a strong relationship. Protecting Your Relationship It's important to protect our relationship by actively engaging in conversations and listening to our partners. We need to exercise self-control and prioritize our relationship over our emotions. Always remember that our actions and words have a significant impact and can save or damage our relationship. Enhancing Your Relationship Intimacy is the cornerstone of a healthy relationship. It's not just about physicality. It's about creating a connection with our partner and making them feel appreciated. Whether it's quality time together, creating memories, learning new things, or celebrating milestones together, these small gestures can enhance the foundation upon which our relationship is built. Understanding and Overcoming Relationship Challenges Relationship challenges can be daunting, so it's essential to understand them in-depth and have strategies in place to overcome them. Financial Issues Money can be a recurring problem in any relationship. Sharing chores and expenses fairly can be tricky. Large purchases should be discussed before making them to avoid souring the relationship. Open communication and transparency are essential to addressing any financial issues. Parenting Issues Parenting can be a complex issue in any relationship. Parental roles need to be established, and both partners should make an effort to create a co-parenting relationship that works for them. Always remember to prioritize your relationship and designate time and family rituals to keep your relationship strong. Personal Issues Personal issues such as personal wounds, regrets, or material possessions can impact any relationship. It's essential to work through these issues on a personal level to prevent their impact on the relationship. Trying new adventures and experiences together could help build a stronger bond. Conflict Resolution Addressing conflicts is important for healthy relationships. Apologizing and making amends for our mistakes is vital, as well as sharing difficult information and being vulnerable. It is also vital to remember to have fun together and keep the relationship light-hearted and enjoyable. Building and maintaining a strong relationship takes time, effort, and conscious prioritization. It's important to overcome challenges and prioritize our relationship. This prioritization includes individual compromises and acceptance, prioritizing our relationship over our emotions, and working through challenges both together and individually. By doing so, we can create a long-lasting and rewarding relationship. In conclusion, we have explored the importance of effective communication, asking the right questions, and addressing common challenges in building a strong and healthy relationship. We have discussed the significance of compromise, acceptance, emotional protection, self-control, and prioritizing our relationship over other issues. Whether we are working through financial or parenting issues, personal struggles or conflicts, or simply trying to enhance our relationship and intimacy, our success, and satisfaction in our relationship depends on our ability to work together, overcome challenges, and prioritize our relationship. Investing time and effort into our relationship can bring great rewards and lead to a fulfilling and lasting relationship.
What are the 12 states created by General Gowon in 1967? In a move to check the influence of Ojukwu's government in the East, Gowon announced on 5 May 1967 the division of the 3 Nigerian regions into 12 states: North-Western State, North-Eastern state, Kano State, North-Central State, Benue-Plateau State, Kwara State, Western State, Lagos State, Mid-Western State, and, from … How many states did Gowon create in 1967? General Yakubu Gowon created twelve states out of the four regions that existed at that time appointing a governor to head them. How many states did Nigeria have in 1967? In 1967, the regions were replaced by 12 states by military decree. From 1967 to 1970 the Eastern Region attempted to secede, as a nation called Biafra during the Nigerian civil war. In 1976, seven new states were created, making 19 altogether. How many states did Obasanjo create? Chief of Staff, Supreme Headquarters: 1975–76 On the recommendation of the Irifeke Commission, the government also announced the creation of seven new states; at Obasanjo's insistence, Abeokuta was to become the capital of one of these new states, Ogun. What are the state created in 1967? List of Nigerian states by date of statehood State \| Date created \| Preceding Entity \| Kwara State \| 27 May 1967 \| Northern Region; known as West Central State from 1967 to 1976. \| Lagos State \| 27 May 1967 \| Federal Territory of Lagos and Colony Province \| Nasarawa State \| 1 October 1996 \| Plateau State \| Niger State \| 3 February 1976 \| North-Western State \| What is the oldest state in Nigeria? Deducing from the dates of creation of states in the country, Cross River, Lagos, Kaduna, Kano, Kwara and Rivers states respectively are the oldest states in Nigeria. These six states were all formed on the 27th of December, 1967. How many state did Murtala Muhammed created? On February 3, 1976, the Military Government of Murtala Muhammed created new states and renamed others, the states he created include: Bauchi, Benue, Borno, Imo, Niger, Ogun, and Ondo. This brought the total number of states in Nigeria to nineteen in 1976. Which state was created in 1967? List of Nigerian states by date of statehood State \| Date created \| Preceding Entity \| Lagos State \| 27 May 1967 \| Federal Territory of Lagos and Colony Province \| Nasarawa State \| 1 October 1996 \| Plateau State \| Niger State \| 3 February 1976 \| North-Western State \| Ogun State \| 3 February 1976 \| Western State \| How many states did Gen Yakubu Gowon created? General Yakubu Gowon was head of state of Nigeria from August 1966 to July 1975. He reorganized the four regions into twelve states in May 1967. Following is a list of military governors during his regime. How is a State created? New States may be admitted by the Congress into this Union; but no new State shall be formed or erected within the Jurisdiction of any other State; nor any State be formed by the Junction of two or more States, or Parts of States, without the Consent of the Legislatures of the States concerned as well as of the … How is a state created? What is Jack Gowon famous for? Yakubu Gowon (born 19 October 1934), affectionately known as Jack Gowon, is a retired Nigerian Army general and military leader. As Head of State of Nigeria, Gowon presided over a controversial Nigerian Civil War and delivered the famous "no victor, no vanquished" speech at the war's end in an effort to promote healing and reocnciliation. How many years did Gowon rule Nigeria? Gowon's rise to power following the July 1966 counter-coup cemented military rule in Nigeria. Consequently, Gowon is the longest serving head of state of Nigeria, ruling for almost nine years until his overthrow in the coup d'état of 1975 by Brigadier Murtala Mohammed. How did Ojukwu respond to Gowon's announcement? On 30 May 1967, Ojukwu responded to Gowon's announcement by declaring the formal secession of the Eastern Region, which was now to be known as the Republic of Biafra. What is the origin of the word "Gowon"? Gowon is an Ngas (Angas) from Lur, a small village in the present Kanke Local Government Area of Plateau State.
Australian scientists want to try to grow plants on the Moon by 2025 as part of a new mission unveiled Friday, October 7 with the aim of developing a colony. "This project is a first step towards cultivating plants for food, medicine and oxygen production, all of which are crucial to establishing human life on the moon.", the researchers said in a statement. >> Back to the Moon: the article to read to know everything about the Artemis mission, a new chapter in the conquest of space Brett Williams, a plant biologist at the Queensland University of Technology in eastern Australia, said the seeds will be carried by the Beresheet 2 spacecraft – an Israeli private space mission. After landing and once in the ground, the seeds will be watered in a sealed chamber and scientists will watch for any signs of germination. The beginnings of human life on the Moon The types of plants will be chosen according to their ability to withstand extreme weather conditions but also according to the speed of their germination. Apart from creating the beginnings of a human life on the Moon, this mission could also serve as a laboratory to find solutions to the food security problems caused by global warming, suggests Caitlin Byrt, professor at the Australian National University. "If you can create a system to grow plants on the moon, then you can create a system to grow food in some of the harshest environments on Earth", she noted in a statement. This project is led by the organization Lunaria One, which includes Australian and Israeli scientists.
Selling public domain books on Amazon can be a profitable venture for book enthusiasts and entrepreneurs alike. Public domain books are works whose copyright has expired, making them available for anyone to use, modify, or sell. This article will provide a comprehensive step-by-step guide on how to successfully sell public domain books on Amazon. Whether you're an experienced seller looking to expand your offerings or a newcomer seeking a new source of income, this guide will walk you through the process, from understanding the concept of public domain books to effectively marketing your products on Amazon. Understanding Public Domain Books Before diving into the world of selling public domain books on Amazon, it's crucial to understand what exactly public domain books are. In simple terms, public domain books are works that are not protected by copyright and are available for public use. This means that anyone can print, distribute, or sell these books without seeking permission from the original copyright holder. Public domain books can include a wide range of literary works, such as novels, poetry, plays, essays, and even scientific papers. These books can span various genres and time periods, offering a treasure trove of knowledge and entertainment for readers. One of the key factors that determine if a book is in the public domain is the expiration of copyright. Copyright protection typically lasts for a specific period of time, after which the work enters the public domain. The duration of copyright varies depending on the country and the year the work was published. For example, in the United States, works published before 1926 are generally considered to be in the public domain. Benefits of Selling Public Domain Books There are several advantages to selling public domain books on Amazon. Firstly, the vast selection of public domain books allows sellers to cater to various niche markets and target a wide range of customers. Whether it's classic literature, historical documents, or obscure works from lesser-known authors, there is a public domain book for every reader's interest. Additionally, since these books are freely available, sellers can acquire inventory without incurring high costs. This is particularly beneficial for independent sellers or small businesses looking to expand their book offerings without breaking the bank. By leveraging the public domain, sellers can access a vast library of content that can be repackaged and presented to customers in unique and creative ways. Moreover, public domain books often have a timeless appeal, making them attractive to vintage book collectors and history enthusiasts. These books offer a glimpse into different eras, allowing readers to immerse themselves in the past and gain a deeper understanding of historical events, cultural movements, and societal norms. Furthermore, selling public domain books can be a sustainable business model. Unlike books protected by copyright, which may go out of print or require ongoing licensing agreements, public domain books are perpetually available. This means that sellers can establish a consistent supply of inventory and build a loyal customer base over time. Lastly, selling public domain books can also be a way to contribute to the preservation of cultural heritage. By making these works accessible to a wider audience, sellers play a role in ensuring that valuable literary and historical resources are not forgotten or lost to time. Preparing to Sell Public Domain Books on Amazon Selecting the Right Public Domain Books Choosing the right public domain books to sell on Amazon is crucial for success. Consider factors such as the book's relevance, demand, and potential profit margins. Conduct thorough research to identify popular genres, authors, or specific books that are in high demand. This will enable you to curate a selection that appeals to a broad customer base and maximizes your sales potential. When selecting public domain books, it's important to keep in mind the interests and preferences of your target audience. Analyze market trends and customer reviews to gain insights into what readers are looking for. Are there any specific genres that are currently trending? Are there any classic books that have stood the test of time and continue to captivate readers? By understanding the preferences of your potential customers, you can make informed decisions about which public domain books to include in your inventory. Furthermore, consider the condition of the books you plan to sell. While public domain books are often older works, it's essential to ensure that they are still in good condition. Customers value quality, and providing well-preserved books will enhance their overall shopping experience. Take the time to inspect each book carefully, checking for any damage or signs of wear and tear. Investing in the restoration or repair of valuable public domain books can significantly increase their market value and attract discerning buyers. Legal Considerations for Selling Public Domain Books While public domain books can be freely used and sold, it's essential to understand the legal considerations associated with selling them. Familiarize yourself with copyright laws in your jurisdiction to ensure compliance. It's crucial to know the duration of copyright protection for different works and when they enter the public domain. In addition to copyright laws, be cautious of unofficial reproductions or editions that may infringe upon copyright or trademarks. Some unscrupulous sellers may attempt to pass off unauthorized copies as genuine public domain books. To protect your reputation as a seller and maintain the trust of your customers, always verify the authenticity and legality of the books you intend to sell. Consider partnering with experts or legal advisors who specialize in intellectual property rights to ensure that your business practices align with legal requirements. They can provide guidance on navigating potential legal pitfalls and help you establish a solid foundation for your public domain book-selling venture. By adhering to legal guidelines and maintaining high ethical standards, you can build a reputable business that not only generates revenue but also contributes to the preservation and appreciation of classic literature. Setting Up Your Amazon Seller Account Steps to Create an Amazon Seller Account Creating an Amazon Seller Account is the first step to selling your public domain books on the platform. Visit the Amazon Seller Central website and follow the step-by-step instructions to set up your account. Provide accurate and detailed information about your business, including shipping policies, return procedures, and customer service details. Remember to verify your identity and bank account information to enable smooth transactions. Once you have successfully set up your Amazon Seller Account, you gain access to a wide range of tools and resources that can help you manage and grow your business. These tools include inventory management, order fulfillment, and customer communication features. By utilizing these tools effectively, you can streamline your operations and provide a better experience for your customers. Additionally, Amazon offers various advertising and promotional opportunities to help you increase your visibility and reach more potential buyers. You can take advantage of sponsored product ads, brand stores, and deals to attract more customers and boost your sales. It's important to explore and experiment with these marketing options to find the strategies that work best for your business. Understanding Amazon's Selling Policies Familiarize yourself with Amazon's selling policies to avoid any potential issues or account suspensions. Ensure that you comply with their guidelines regarding product listings, pricing, customer service, and fulfillment. Adhering to these policies will allow you to build a positive reputation as a reputable seller and provide a seamless buying experience for customers. Amazon has strict policies in place to protect both buyers and sellers. They have guidelines on product condition, prohibited items, and intellectual property rights. It's crucial to thoroughly understand these policies and ensure that your listings and products meet all the requirements. By doing so, you can avoid any potential conflicts or legal issues that may arise. Furthermore, Amazon values customer satisfaction and places a strong emphasis on providing excellent customer service. As a seller, it's important to promptly respond to customer inquiries, address any concerns or issues, and provide accurate and detailed information about your products. By delivering exceptional customer service, you can build trust with your buyers and increase the likelihood of positive reviews and repeat purchases. Lastly, it's essential to stay updated with any changes or updates to Amazon's selling policies. The platform regularly updates its policies and guidelines to adapt to market trends and ensure a fair and secure marketplace. Keeping yourself informed about these changes will help you stay compliant and maintain a successful selling business on Amazon. Listing Your Public Domain Books on Amazon Writing an Effective Book Description When listing your public domain books on Amazon, crafting an enticing book description is crucial. A well-written description can attract potential buyers and provide them with essential information about the book's content, condition, and unique selling points. Highlight any special features, such as illustrations or annotations, and include keywords that will enhance the book's visibility in Amazon's search results. Pricing Your Public Domain Books Setting the right price for your public domain books is essential for attracting buyers while ensuring a reasonable profit margin. Research the pricing of similar books on Amazon to gauge market value. Take into account factors like the book's condition, rarity, and demand. It's advisable to set competitive prices that align with market trends to increase the chances of sales. Marketing Your Public Domain Books Utilizing Amazon's Marketing Tools To increase the visibility and sales of your public domain books, take advantage of Amazon's marketing tools. Utilize features such as Sponsored Product Ads or Headline Search Ads to promote your books to a targeted audience. Additionally, participate in Amazon's book promotions and deals to attract more customers. Aim to build positive customer reviews, as they can significantly impact your book's credibility and sales potential. Building a Brand for Your Book Business Building a brand for your book business can help differentiate you from competitors and establish a loyal customer base. Consider creating a unique brand name, logo, and tagline that reflect your business values and appeal to your target market. Develop a consistent brand voice in your book listings, website, and social media presence. Engage with customers through blog posts, newsletters, and author interviews, showcasing your expertise and passion for books. In conclusion, selling public domain books on Amazon can be a rewarding and profitable endeavor. By understanding the concept of public domain books, selecting the right inventory, and effectively marketing your products, you can create a successful book business on Amazon. Remember to comply with legal considerations and Amazon's selling policies to provide a positive buying experience for customers. With dedication, research, and strategic marketing, you can capitalize on the vast potential of public domain books and establish yourself as a prominent seller in the Amazon marketplace. Take Your Amazon Book Business to the Next Level Ready to elevate your success in selling public domain books on Amazon? Your eCom Agent is here to revolutionize the way you manage your online book business. With our advanced AI tools, you can effortlessly analyze product reviews, optimize your detail pages, and develop better products that resonate with your audience. Say goodbye to the time-consuming tasks and embrace the power of AI to enhance your operations. Subscribe to Your eCom Agent's AI Tools today and transform your Amazon selling experience!
Emergency Room Boarding: A Critical Examination of its Impact on Patient Care Emergency room (ER) boarding, a practice where patients are held in the emergency department beyond the medically necessary time for admission or transfer, has garnered significant attention due to its implications for patient care and healthcare system efficiency. This essay seeks to delve into the complexities surrounding ER boarding, analyzing its effects on patient outcomes, resource utilization, and potential strategies for mitigation. One of the foremost concerns associated with ER boarding is its adverse impact on patient care quality. Prolonged stays in the emergency department can lead to delays in receiving appropriate treatment, exacerbation of medical conditions, and increased risk of adverse events. Research indicates that prolonged boarding times are associated with higher mortality rates, highlighting the urgency of addressing this issue to safeguard patient safety and well-being (Viccellio et al., 2009). Moreover, the overcrowded and often chaotic environment of the emergency department during boarding can compromise the delivery of timely and personalized care, further compounding the challenges faced by patients and healthcare providers alike. In addition to its implications for patient care, ER boarding also poses significant challenges for healthcare resource allocation and system efficiency. Boarded patients occupy valuable ER beds, leading to congestion and bottlenecks in the emergency department, which, in turn, can impede the timely assessment and treatment of incoming patients. This inefficiency not only strains the resources of the emergency department but also contributes to longer wait times for all patients seeking emergency care, eroding public trust in the healthcare system and exacerbating dissatisfaction among both patients and providers. In conclusion, ER boarding represents a multifaceted challenge with far-reaching implications for patient care quality, healthcare resource utilization, and system efficiency. Addressing this issue requires a comprehensive approach that encompasses both short-term interventions to alleviate immediate pressures on emergency departments and long-term strategies aimed at addressing systemic issues contributing to boarding. By prioritizing patient safety, optimizing resource allocation, and fostering collaboration among stakeholders, healthcare organizations can work towards mitigating the detrimental effects of ER boarding and improving the overall quality and efficiency of emergency care delivery.
INTRODUCTION. A conviction in the mind of its total ignorance of the nature and of the specific attributes of the Godhead, and a sense of doubt respecting the real essence of the soul, give rise to feelings of great dissatisfaction with our limited powers, as well as with all human acquirements which fail to inform us on these interesting points. On the other hand, a notion of the existence of a supreme superintending power, the Author and Preserver of this harmonious system, who has organized and who regulates such an infinity of celestial and terrestrial objects, and a due estimation of that law which teaches that man should do unto others as he would wish to be done by, reconcile us to human nature, and tend to render our existence agreeable to ourselves and profitable to the rest of mankind. The former of these sources of satisfaction, viz., a belief in God, prevails generally; being derived 47. either from tradition and instruction, or from an attentive survey of the wonderful skill and contrivance displayed in the works of nature. 2 The latter, although it is partially taught also in every system of religion with which I am acquainted, is principally inculcated by Christianity. This essential characteristic of the Christian religion I was for a long time unable to distinguish as such, amidst the various doctrines I found insisted upon in the writings of Christian authors, and in the conversation of those teachers of Christianity with whom I have had the honour of holding communication. Amongst, these opinions, the most prevalent seems to be, that no one is justly entitled to the appellation of Christian who does not believe in the divinity of Christ and of the Holy Ghost, as well as in the divine nature of God, the Father of all created beings. Many allow a much greater latitude to the term Christian, and consider it as comprehending all who acknowledge the Bible to contain the revealed will of God, however they may differ from others in their interpretations of particular passages of Scripture; whilst some require from him who claims the title of Christian, only an adherence to the doctrines of Christ, as taught by himself, without insisting on implicit confidence in those of the Apostles, as being, except when speaking from inspiration, like other men, liable to mistake and error. That they were so, is obvious from the several instances of differences of opinion amongst the Apostles recorded in the Acts and Epistles. Voluminous works, written by learned men of particular sects for the purpose of establishing the truth, consistency, rationality, and priority of their own peculiar doctrines, contain such variety of arguments, that I cannot hope to be able to adduce here any new reasonings of sufficient novely and force to attract the notice of my readers. Besides, in matters of religion particularly men in general, through prejudice and partiality to the opinions which they once form, pay little or no attention to opposite sentiments (however reasonable they may be) and often turn a deaf ear to what is most consistent with the laws of nature, and conformable to the dictates of human reason and divine revelation. At the same time, to those who are not biased by prejudice, and who are, by the grace of God, open to conviction, a simple enumeration and statement of the respective tenets of different sects may be a sufficient guide to direct their inquiries in ascertaining which of them is most consistent with the For these sacred traditions, and most acceptable to common sense. reasons, I decline entering into any discussion on those points, and fellowconfine my attention at present to the task of laying before my creatures the words of Christ, with a translation from the English into Sanscrit, and the language of Bengal. I feel persuaded that by separating from the other matters contained in the New Testament, the moral precepts found in that book, these will be more likely to produce the desirable effect of improving the hearts and minds of men of different persuasions and degrees of understanding. For, historical and some other passages are liable to the doubts and disputes of free-thinkers and anti-christians, especially miraculous relations, which are much less wonderful than the fabricated tales handed down to the native of Asia,† and consequently would be apt, at best, to carry little weight with them. On the contrary, moral doctrines, tending evidently to the maintenance of the peace and harmony of mankind at large, are beyond the reach of metaphysical Vide Acts, ch. xi. 2, 3, ch. xv. 2, 7; I Corinthians, ch. i. 12 ; Galatians, ch. ii. 11, 12, 13. † Agasti is famed for having swallowed the ocean, when it had given him offence, and having restored it by urinary evacuation : at his command, also, the Vindhya range of mountains prostrated itself, and so remains. (Wilson's Dictionary.] perversion, and intelligible alike to the learned and to the unlearned. This simple code of religion and morality is so admirably calculated to elevate men's ideas to high and liberal notions of God, who has equally subjected all living creatures, without distinction of caste, rank or wealth, to change, disappointment, pain and death, and has equally admitted all to be partakers of the bountiful mercies which he has lavished over nature, and is also so well fitted to regulate the conduct of the human race in the discharge of their various duties to themselves, and to society, that I cannot but hope the best effects from its promulgation in the present form. thou, when thou fastest, anoint thine head, and wash thy face; that thou appear not unto men to fast, but unto thy Father who is in secret; and thy Father, who seeth in secret, shall reward thee openly. Lay not up for yourselves treasures upon earth, where moth and rust doth corrupt, and where thieves break through and steal; but lay up for yourselves treasures in heaven, where neither moth nor rust doth corrupt, and where thieves do not break through nor steal: for where your treasure is, there will your heart be also. The light of the body is the eye: if therefore thine eye be single, thy whole body shall be full of light. But if thine eye be evil, thy whole body shall be full of darkness. If therefore the light that is in thee be darkness, how great is that darkness! : No man can serve two masters: for either he will hate the one, and love the other; or else he will hold to the one, and despise the other. Ye cannot serve God and Mammon. Therefore I say unto you, Take no thought for your life, what ye shall eat, or what ye shall drink; nor yet for your body, what ye shall put on. Is not the life more than meat, and the body than raiment? Behold the fowls of the air for they sow not, neither do they reap, nor gather into barns; yet your heavenly Father feedeth them. Are ye not much better than they? Which of you by taking thought can add one cubit unto his stature? And why take ye thought for raiment ? Consider the lilies of the field, how they grow; they toil not, neither do they spin: aud yet I say unto you, That even Solomon in all his glory was not arrayed like one of these. Wherefore, if God so clothe the grass of the field, which to-day is and to-morrow is cast into the oven, shall he not much more clothe you, O ye of little faith? Therefore take no thought, saying What shall we eat? or, What shall we drink? or, Where withal shall we be clothed? (For after all these things do the Gentiles seek :) for your heavenly Father knoweth that ye have need of all these things. But seek ye first the kingdom of God, and his righteousness; and all these things shall be added unto you. Take therefore no thought for the morrow: for the morrow shall take thought for the things of itself. Sufficient unto the day is the evil thereof. Judge not, that ye be not judged. For with what judgment ye judge, ye shall be judged: and with what measure yo mete, it shall be measured to you again. And why beholdest thou the mote that • Matthew, chap. vii. \|
SEO still holds immense potential for growth, given the ever-changing landscape of search engine algorithms. While some may argue that it is premature to discuss the future implications of SEO, it is essential to acknowledge that technology has advanced to a point where predicting every outcome is no longer feasible. But change can be intimidating, and the field of SEO has witnessed its fair face of transformations. However, the underlying constant remains: searchers will always strive to find relevant information, brands, and businesses through search engines. Although direct answers, increased advertisement prominence, and other factors have reduced exposure and click-through rates from organic search results, we have yet to witness a worst-case scenario. The SEO industry has demonstrated resilience and adaptability, continually evolving and growing stronger. Table of contents What does the rise of AI entail for SEO? Let us delve into the implications of this question. Many friends and colleagues have recently asked me if SEO is still relevant or if it will exist alongside the emergence of AI. Regardless of the appearance of search engines or the specific sources individuals use to find information, brands, and companies will always aspire to connect with their target audiences. Whether through Google, AI platforms, or even household devices like refrigerators, the goal remains to establish a connection between brands and their audiences. This connection could manifest through chatbots, AI, connected devices, voice assistants, or even sentient robots integrated into our daily lives. Personally, I am fascinated by the potential applications of AI for my agency, businesses, and a consumer. The Future of SEO in 2023 and Onwards Technological advancements, shifts in user behavior, and the evolution of search engine algorithms will profoundly influence the future of SEO. Here are several key trends that we anticipate in the future of SEO: Voice search will witness an increased prevalence With the growing popularity of smart speakers and voice assistants, optimizing content for voice search will become paramount in SEO strategies. Businesses must align their content with natural language queries and long-tail keywords to achieve higher rankings in voice search results. Artificial Intelligence (AI) and Machine Learning (ML) AI and ML will progressively gain significance in SEO as search engines become more adept at understanding and interpreting user search intent. Consequently, businesses must prioritize creating high-quality and relevant content that fulfills user search intent. Video content will maintain its crucial role Video content will remain an integral component of online marketing, and businesses must optimize their video content to enhance visibility on Search Engine Results Pages (SERPs). Expertise, Authority, and Trustworthiness (E-A-T) E-A-T will continue to be a vital factor in determining a website's ranking on SERPs. Websites that demonstrate expertise, authority, and trustworthiness through their content will enjoy higher rankings. Understanding Answer Engine Optimization (AEO) SEO has long been a fundamental aspect of digital marketing strategies. Nevertheless, with the progress of technology and the evolution of user behavior, a fresh method of optimization has surfaced, Answer Engine Optimization (AEO). For individuals who are not acquainted with AEO, it entails enhancing the content specifically for search queries formulated as questions, aiming to secure a position as the highlighted snippet or answer box in search engine results pages (SERPs). The rise of virtual assistants and voice search has magnified the importance of AEO, as users are increasingly inclined to seek answers through question-based queries. In light of the rise of AI-driven language models such as ChatGPT, it is imperative for businesses to adjust their content optimization strategies to encompass Answer Engine Optimization (AEO). This approach emphasizes providing direct answers to user queries, necessitating investments in high-quality content, structured data utilization, embracing new technologies, and monitoring results to identify the most effective strategies. By doing so, businesses can enhance their chances of appearing in AEO-related search results and thrive in an increasingly AI-driven search environment. Leveraging AI for Success We should wholeheartedly embrace and leverage AI. Within my team, we are already integrating AI into our internal processes and exploring its applications in various aspects of SEO, digital marketing, and web development. At a time when resources are becoming scarcer, leveraging AI has proven to be a blessing. While content quality remains paramount in the current landscape, the advent of AI-generated content will undoubtedly result in an increase in the overall quality of content produced. Immediate Action Steps To navigate the current and future SEO landscape successfully, we must continue to employ effective strategies while remaining mindful of emerging trends. Prioritize technical, on-page, and off-page SEO, understanding how SERP features can work both for and against you. Develop a solid, measurable strategy that aligns with your objectives. Invest in SEO for the long term and allocate the necessary resources to support it. Additionally, capitalize on the potential of AI for your organization, processes, and opportunities. Stay ahead and avoid falling behind. However, while pursuing these endeavors, it is crucial not to lose sight of the present. Do not abandon ship on SEO, as it remains a fundamental driver toward achieving your goals. While it may undergo name changes in the future. SEO is not dying, it will continually evolve and adapt to meet the demands of the ever-changing landscape. People will always seek and search, and brands and organizations will strive to be discovered. SEO remains relevant in 2023, and businesses aiming to thrive online must prioritize SEO best practices. Technological progress, changes in user behavior, and the continuous development of search engine algorithms will exert substantial influence on the trajectory of SEO in the coming years. Businesses that remain proactive in adopting these trends will be well-positioned to succeed in the dynamic digital landscape. One thing is clear, businesses that can adapt to the evolving search technology landscape. And remain ahead of the curve will be the ones that thrive in the digital world. Therefore, enhance the quality of your content, optimize it to cater to question-based queries, and wholeheartedly embrace the dawn of a new era in search technology. The future shines bright – or at least as bright as a computer screen.
Pseudo Gout Relief Gout arthritis is one of the most excruciating types of joint inflammation, as well as it impacts the big toes particularly terribly. It is likewise called "dermatology's worst headache". The discomfort connected with gout arthritis is fairly unbearable and also numerous patients find it difficult to bear the pain. The discomfort normally starts in the huge toe and also moves down the other toes, making the individual really feel as if they are being torn apart. Gout pain assaults frequently persist, creating the individual a great deal of pain. Pseudo Gout Relief There are lots of clinical treatments that can be provided for gout pain. These include antacids, corticosteroids, diuretics, rinses, and several others. Every one has its own mechanism of activity and lugs its very own dangers. Therefore it is essential to recognize every one and also pick the best clinical therapy according to the signs and symptoms and also complications that the patient is experiencing. Many individuals have actually discovered that the best means to treat their gout entails utilizing different all-natural self-management strategies.Pseudo Gout Relief Pseudo Gout Relief Gout arthritis is triggered by an illness called hyperuricemia, in which there is way too much uric acid in the body. The kidneys make excessive uric acids in the blood, which are then transferred in the bones, ligaments as well as other joints. Along with the huge toe, common joints that are frequently influenced are the elbow joint, ankle, and even the wrist. This condition is more usual amongst males than women, yet it can take place at any kind of age. The primary threat elements for gout pain are weight problems, alcohol abuse, smoking cigarettes, high blood pressure, inadequate diet as well as consuming routines and a family history of the condition. Pseudo Gout Relief Gout as well as joint inflammation are connected due to the fact that many lifestyle factors, such as excess weight, hypertension, poor diet plan and also absence of physical activity, can result in the growth of the joint problem. Therefore a gout person should customize his or her life style so regarding avoid the danger elements, while at the same time trying to lower the symptoms as well as issues of the arthritis. For this purpose the gout sufferer should take on a positive attitude. These self-managing strategies consist of a regular and vigorous physical activity routine that promotes the formation of healthy and balanced joints and also aids the individuals to come to be active, while maintaining a healthy and balanced weight. While trying to manage the signs and symptoms, it is additionally crucial to take the right medicine that is specifically made for the therapy of gout arthritis. The use of NSAIDS or nonsteroidal anti-inflammatory medications such as aspirin, advil, naproxen, and so on, is recommended in order to manage the inflammation in the joint. An additional choice is to take the prescription ointment or the oral tablet of the advised dosage of the medicine. While taking on these self-management approaches it is necessary to keep in mind that the gout pain strike can return if the medicine is quit quickly; so it is best to walk slowly and very carefully with these medicines. One more option to regulate the attack is by quiting the intake of all medicines other than the NSAIDS. You have to see your doctor to start taking the NSAIDS daily. You have to not stop taking your other medicines instantly, as this may also lead to withdrawal signs and symptoms and also enhance the threat of an assault returning. On top of that you must consult your physician regarding the feasible withdrawal adverse effects, like nausea, vomiting, indigestion, drowsiness, headache and also dizziness. He may additionally advise a different treatment for your condition other than NSAIDS. Gout and also NSAIDS and also their partnership are something that you should talk about thoroughly with your physician. There are numerous herbs that may decrease uric acid levels in the blood stream and decrease the threat of gout pain assaults. One such natural herb that is generally suggested by holistic medical professionals and nutritional experts is Milk Thistle. Milk Thistle can be absorbed supplement type or as a tea. It has been shown to prevent the formation of uric acids by battling the enzymes that cause purine metabolic rate. Research studies have also revealed that by taking Milk Thistle daily the risk of gout and its signs are minimized by virtually half. To help in reducing swelling as well as soothe discomfort connected with gout pain, clients are encouraged to take a cupful of ginger juice each day. Ginger will certainly increase discomfort thresholds as well as will certainly aid to reduce inflammation. By consuming alcohol one or two ginger beverages a day, together with Milk Thistle as well as other natural herbs, gout sufferers can enjoy efficient pain alleviation and also decrease the possibility of a reoccurrence of gout.
Starting a business can be both exciting and overwhelming, especially when it comes to choosing the right legal structure. For entrepreneurs in Pennsylvania, forming a single member LLC is a popular option due to its simplicity and flexibility. A single member LLC is a limited liability company with only one owner, providing personal asset protection while allowing for pass-through taxation. If you're considering starting a single member LLC in Pennsylvania but don't know where to begin, this article is for you. We've put together a simple guide that will walk you through the steps of forming your own single member LLC in the state of Pennsylvania. From selecting a name to filing your paperwork with the state, we'll cover everything you need to know to get your business up and running as quickly and smoothly as possible. When starting a single member LLC in Pennsylvania, it's important to understand the necessary steps, like how to get LLC in pennsylvania. From filing your Articles of Organization to obtaining an Employer Identification Number (EIN), this guide will walk you through the process seamlessly. When it comes to starting a business, one important step to consider is how to get an LLC in Pennsylvania. This process may seem daunting, but with the right guidance, forming a single member LLC can be a straightforward endeavor. To successfully establish a single member LLC in Pennsylvania, making sure you understand the necessary steps, such as handling the paperwork and adhering to the state's regulations for how to get an LLC in Pennsylvania, is essential. When starting a single member LLC in Pennsylvania, it's crucial to seek assistance from the best pennsylvania LLC services available. These services provide invaluable guidance throughout the incorporation process, ensuring seamless compliance with local regulations and optimizing your business's success. If you're a budding entrepreneur in Pennsylvania, starting a single member LLC is a excellent choice. With its simplified structure and liabilities protection, setting up a pennsylvania single member llc allows you to officially establish your business while also protecting your personal assets. Related Content – Exceptional LLC Formation Assistance in Nevada for 2023 Understanding The Benefits Of A Single Member Llc Starting a single member LLC in Pennsylvania can provide numerous benefits, such as tax advantages and liability protection. One of the most significant advantages of forming an LLC is that it offers personal asset protection for its members. This means that the owner's personal assets are not at risk if the business encounters financial difficulties or legal issues. Another benefit of forming a single member LLC is the potential for tax advantages. In most cases, the LLC's profits flow through to the owner's personal income tax return, which allows for a lower tax rate than if the business were taxed separately. Additionally, an LLC also provides flexibility in terms of how it can be taxed, allowing the owner to choose between being taxed as a sole proprietorship or a corporation depending on their individual needs. Overall, starting a single member LLC in Pennsylvania can be advantageous for those looking for personal liability protection and potential tax savings. Explore These Posts – Exceptional LLC Formation Assistance in New Hampshire for 2023 Choosing A Name For Your Business As you begin to think about naming your single member LLC, imagine standing in front of a storefront with your business name displayed boldly on the sign. What do you want people to see and feel when they read it? Your business name should be catchy, memorable, and easy to pronounce. Additionally, it is important to ensure that your chosen name does not violate any trademark considerations or naming restrictions. Trademark considerations are crucial when choosing a business name. You don't want to infringe on someone else's intellectual property rights by using a name that is already trademarked. You can check the United States Patent and Trademark Office's database for registered trademarks before finalizing your business name. Moreover, Pennsylvania has specific naming restrictions for businesses that must be followed, such as avoiding names that imply illegal activities or using words like 'bank' or 'insurance' without proper licensing. By keeping these factors in mind, you can choose an effective and legally sound name for your single member LLC. Related Pages – Exceptional LLC Formation Assistance in New Jersey for 2023 Filing Your Articles Of Organization After deciding to form a single-member LLC in Pennsylvania, the next step is to file your Articles of Organization with the state. This document formally establishes your LLC and should include essential details such as your company name, registered agent's name and address, business purpose, member information, and any other filing requirements mandated by the state. Before filing your Articles of Organization, it is essential to consider all legal considerations associated with forming an LLC. These may include obtaining necessary business licenses and permits, creating an operating agreement that outlines how the business will be run, obtaining insurance coverage for potential liabilities, and complying with tax obligations. By taking these steps before filing your Articles of Organization, you can ensure that you are setting up a strong foundation for your single-member LLC in Pennsylvania. Obtaining Necessary Permits And Licenses I'll need to file for an LLC if I want to start a single member LLC in Pennsylvania. After that, I'll have to register with the state to officially form the LLC. Finally, I'll need to obtain any licenses or permits necessary to run my business. Filing For Llc If you're ready to start your single member LLC in Pennsylvania, filing for the LLC is a crucial step. First, it's important to understand the legal requirements for forming an LLC in the state. Once you have that information, you can file the necessary paperwork with the Pennsylvania Department of State. The filing fees vary based on the type of LLC you're forming and the way you choose to file. Make sure to double-check all required documentation to avoid any delays or additional fees. Remember that proper filing ensures that your business is legally recognized and protected under state law. Registering With State Now that you've successfully filed for your single member LLC in Pennsylvania, the next step is to obtain any necessary permits and licenses. To operate legally, your business may require certain permits or licenses depending on its industry and location. Registering with the state is a crucial part of this process as it ensures that you comply with all relevant laws and regulations. Keep in mind that obtaining these permits and licenses may involve additional filing fees and processing time, so be sure to factor those into your timeline and budget. Proper registration will help ensure that your business can operate without any legal issues down the line. Check Out These Related Posts – Exceptional LLC Formation Assistance in Nebraska for 2023 Obtaining Licenses Now that you've taken care of registering your single member LLC in Pennsylvania, the next step is to make sure you have all necessary licenses and permits to operate your business legally. Depending on the industry and location of your business, you may need to obtain specific licenses or permits before conducting any operations. The application process for such licenses and permits can be time-consuming, and there may be additional filing fees involved as well. Therefore, it's important to research what documents are required beforehand so that you can factor them into your budget and timeline accordingly. By obtaining the necessary licenses and permits, you'll ensure that your business operates without any legal issues down the line. Maintaining Your Single Member Llc In Pennsylvania Now that you have obtained all the necessary permits and licenses for your single member LLC in Pennsylvania, it's time to focus on maintaining your business. One important aspect of running an LLC is complying with taxation requirements. As a single member LLC, you will need to file taxes as a sole proprietorship or choose to be taxed as a corporation. It's important to consult with a tax professional to understand which option is best for your business. In addition to taxation requirements, record keeping tips are also crucial for maintaining your single member LLC in Pennsylvania. Keeping accurate records of financial transactions, including income and expenses, will help you stay organized and compliant with state regulations. Consider using accounting software or hiring an accountant to assist with record keeping and ensure accuracy. By staying on top of taxation requirements and record keeping, you can set your single member LLC up for success in the long run. In conclusion, starting a single member LLC in Pennsylvania is a straightforward process that can be completed relatively quickly. By understanding the benefits of this type of business entity, choosing an appropriate name, and filing your Articles of Organization, you can establish your business with ease. Don't forget to obtain any necessary permits and licenses as well. Once your LLC is up and running, it's important to keep up with maintenance tasks like filing annual reports and paying taxes on time. With dedication and attention to detail, you can successfully operate your single member LLC in Pennsylvania and achieve your entrepreneurial goals. So go ahead and take the first step towards creating a thriving business today! LLCKnow is the ultimate guide to forming and managing your LLC. Get the inside scoop on LLCs with LLCKnow – your go-to resource for all things limited liability company.
The stethoscope is a medical device that has been used for centuries. However, the modern stethoscope has undergone significant improvements over the years. The stethoscope shown in this photograph features a modern design that is lightweight and comfortable to use. This makes it ideal for medical professionals who need to use it for extended periods. One of the most significant improvements in modern stethoscopes is the quality of sound they produce. They are designed to pick up even the faintest of sounds, making it easier for doctors to diagnose patients accurately. Additionally, some modern stethoscopes are equipped with electronic amplifiers that make it easier to hear sounds in noisy environments. This photograph can be used in a variety of ways. It is perfect for medical professionals who need to create presentations or educational materials. It can also be used by medical supply companies that sell stethoscopes to showcase their products. Additionally, it can be used by medical students who are learning how to use a stethoscope. Overall, this photograph is an excellent representation of the modern stethoscope. It showcases how far this essential medical device has come and how it continues to evolve to meet the needs of medical professionals. Pixel-Shot Team
Systemic light chain amyloidosis (AL) is a clonal plasma cell disorder characterized by the deposition of misfolded immunoglobulin light chains (LC) as insoluble fibrils in organs. The lack of suitable models has hindered the investigation of the disease mechanisms. Our aim was to establish AL LC-producing plasma cell lines and use them to investigate the biology of the amyloidogenic clone. We used lentiviral vectors to generate cell lines expressing LC from patients suffering from AL amyloidosis. The AL LC-producing cell lines showed a significant decrease in proliferation, cell cycle arrest, and an increase in apoptosis and autophagy as compared with the multiple myeloma LC-producing cells. According to the results of RNA sequencing the AL LC-producing lines showed higher mitochondrial oxidative stress, and decreased activity of the Myc and cholesterol pathways. The neoplastic behavior of plasma cells is altered by the constitutive expression of amyloidogenic LC causing intracellular toxicity. This observation may explain the disparity in the malignant behavior of the amyloid clone compared to the myeloma clone. These findings should enable future in vitro studies and help delineate the unique cellular pathways of AL, thus expediting the development of specific treatments for patients with this disorder. Systemic light chain amyloidosis (AL) is a rare monoclonal plasma cell (PC) disorder characterized by the systemic deposition of misfolded immunoglobulin light chains (LC) as insoluble fibrils in organs.1 Without specific therapies patients who present with amyloidogenic LC that target vital organs will ultimately die.2 Furthermore, AL amyloidosis may be found in 10% of patients with multiple myeloma, in whom it confers a worse prognosis.3-6 Unlike in multiple myeloma (MM), in which the clinical picture is dominated by the hyper-proliferative MM clone, in AL severe organ dysfunction is usually caused by a small PC clone producing the amyloidogenic LC.7 Treatment approaches to AL are derived from MM protocols and aim at suppressing the clone with chemotherapy and novel PC targeted agents.8,9 Lessons learned in the clinic reveal that reducing the concentration of the circulating amyloidogenic free LC improves cardiac function and prolongs survival.10,11 This indicates that it is not solely the deposition of the mass of the amyloid in the tissues which causes organ injury1,12,13 and that toxicity of the LC is a fundamental contributor.7 In AL, the PC clones are usually small (median 10% of bone marrow cells) and, interestingly, the free LC levels in AL may be 10 logs lower than in MM irrespective of serious organ damage. Amyloid LC precursors are likely to mediate cellular toxic-ity through a mechanism that causes oxidative stress and activates the apoptotic pathway.1,14 Much research has been performed to determine the molecular factors that make a particular LC protein amyloidogenic, and to elucidate the mechanism of amyloid fibril formation and even to characterize the amyloid formation in vitro, with some success at unveiling the process.1,12,14,15 To date, there are only two characterized amyloidogenic cell lines, which were produced from the same patient.16 Their limits are the lack of an analogous control non-amyloidogenic line, and their ability to produce only one type of LC. Both MM and AL originate from a neoplastic PC clone; however, AL has an attenuated proliferative physiology and different clinical behavior. Several lines of evidence indicate that the amyloidogenic clone is at the crossroads between monoclonal gammopathy of undetermined significance and MM, with less mutation burden,17 more stable genetic status,18 and lower intraclonal heterogeneity19 than MM. Previous reports indicate that amyloid LC determine endoplasmic reticulum oxidative stress in the PC that produce them, sensitizing the clone to the action of proteasome inhibitors and thus providing a molecular basis for the exquisite sensitivity to these agents observed in the clinic.20 The same mechanism has been shown in PC producing LC that also aggregate causing LC deposition disease.21 Here we report the establishment of a model to study the molecular mechanisms underlying amyloid LC proteotoxicity. We used lentiviral vectors that contain cloned LC sequences from patients with AL amyloidosis with cardiac or renal involvement and from patients with MM to enable stable expression of LC in MM cell lines. The purpose of our study was to investigate the effects of amyloid LC on PC proliferation and metabolism, two key aspects that were not explored in the previous two studies that focused on endoplasmic reticulum stress and protein degradation pathways.20,21 Cell lines The cell lines used were: KMS11 and NCI-H929 (MM cell lines), HL60 (an acute promyelocytic leukemia cell line), 721.221 (an HLA-negative B-cell line) and 293T or HEK293T (a human embryonic kidney cell line that expresses a mutant version of the SV40 large T antigen) all kindly donated by Prof Ben-Yehuda (Hadassah Medical Organization, Israel); JJN3 (a MM cell line) kindly donated by Dr Katia Beider (Hebrew University, Israel); HEK293 (a human embryonic kidney cell line) kindly donated by Prof Ariella Oppenheim (Hebrew University, Israel); normal human fibroblasts, kindly donated by Dr Scibienski (Stockholm University, Sweden); and HC92 (a rat cardiomyocyte cell line) kindly donated by Prof Ronen Beni (Hebrew University, Israel). Foreskin fibroblasts, HC92, HEK293 and 293T cells were grown and maintained in Dulbecco modified Eagle medium (Thermo Fisher, USA) while the other cell lines were grown and maintained in Roswell Park Memorial Institute medium (Thermo Fisher, USA). All media were supplemented with 10% fetal calf serum (Thermo Fisher, USA), L-glutamine (29.2 μg/mL), and penicillin (1,000 U/mL)/streptomycin (10 mg/mL) (Biological Industries, Israel) and incubated at 37°C in 5% CO2. All cell lines were passaged bi-weekly and tested for mycoplasma. Generation of cell lines expressing light chains of myeloma and AL amyloidosis patients In order to establish a new model to study amyloidogenesis and its toxic effects in living human cells we used lentiviral vectors to stably express the production of amyloidogenic LC in MM cell lines. The 600 base pair LC gene was cloned within a pCR 2.1-TOPO plasmid as previously described22 (sequence in the Online Supplementary File). The same 600 base pair LC sequence was generated via polymerase chain reaction from this plasmid and inserted into the multiple cloning site of the minusDsRed-GFP expressing lentivirus (kindly donated by Prof. O. Mandelboim). Thus, we generated lentivirus plasmids cloned with amyloidogenic λ LC cDNA sequences from a patient who suffered from cardiac AL [H], another LC cDNA sequence from a second patient who suffered from kidney - nephrotic AL [K] and a LC sequence from a third patient who did not have AL and was denoted non-amyloidogenic MM [M]. All plasmids contained a reporter sequence of green fluorescent protein (GFP) expression. Using 293T cells we generated infectious viral particles containing λ LC and stably transduced three MM cell lines which have the intracellular machinery not only to produce but also to secrete LC proteins. Thus, we were able to create novel MM cell lines that produce, in addition to their own MM k LC,23-25 an amyloidogenic λ LC and GFP. Two separate clones of each AL LC were generated (e.g., M2.3 and M2.4, or K1.4 and K1.10, or H3.8 and H3.5) and then at least three infections of each separate clone were performed on the MM cell lines JJN3, KMS11 and NCI-H292. The number of RNA transcripts for JJN3 and three separate transfections were assessed by RNA sequencing (Figure 1A). Total λ protein in KMS11 lysate (Figure 1B) and GFP expression, determined by flow cytometry (Figure 1C), detected the presence of the LC. Six biological repeats for every LC were tested in this study. These MM cell lines all produced κ LC naturally allowing the λ LC-producing plasmid to be detected and distinguished clearly from the κ production of the cell lines themselves (Figure 1D). The proliferation rate of the three lines was between 36 and 50 h. Additionally, we transduced non-MM cell lines (HL60, 293T, 722.221) with two clones of each AL LC [H] and [K] and MM LC [M] and two separate infections as a further control to determine intracellular toxicity of the amyloidogenic LC on non-PC lines. GFP and λ expression was assessed by flow cytometry (FACSCalibur, BD Bioscience, USA) in order to determine the efficiency of infection (Figure 1C). No decrease in viability or increase in apoptosis was found in the non-PC lines transduced with the AL and MM LC (Online Supplementary Figure S1A, C). However, addition of exogenouse AL LC was toxic (Online Supplementary Figure S1B). In the majority of cases more than 95% of cells were GFP-positive (Figure 1C). Using an enzymelinked immunosorbent assay (Bethyl, TX, USA), we were able to detect the AL LC intracellularly in both MM and non-MM cell lines (Figure 1A, B), but secreted AL and MM LC only in the MM cell lines (Figure 1D). Supernatant was collected from transfected MM cells that secreted their LC into the medium while growing. After 5 days of growth the supernatant was collected and incubated for 48 h with MM cells, primary kidney and heart cells, 721.221 and HL60, which were then assessed for apoptosis by flow cytometry following exposure to the medium containing LC. Significant increases in apoptosis (determined by propidium iodide and annexin V staining) were detected in the primary cells and MM cells when incubated with supernatant containing cardiotoxic [H] and nephrotoxic [K] LC, but not with supernatant containing non-amyloidogenic MM LC [M] (Figure 1E-G). Cell proliferation Ten thousand cells were seeded in wells and every 3 days a sample of cells was removed and enumerated using try pan blue exclusion and a hemocytometer to assess cell growth. Additionally, cell viability and proliferation were assessed using the CellTiter-Glo® kit (Promega, MI, USA), which measures viability and proliferation of cells by quantitating luminescence of ATP. Ten thousand cells were seeded in either quadruplicate or quintuplicate and after 5 days the proliferation was assessed by read-out of luminescence. Cell cycle and apoptosis analysis A re-suspended pellet of 1x106 cells was incubated over-night at 4°C in 1 mL of 100% ethanol (AR. Gadot, Israel) for fixation and to minimize clumping. The cells were then washed with 1 mL phosphate-buffered saline (PBS) and treated with 50 μL of 100 μg/mL RNase A (Sigma-Aldrich, USA) for 30 min at 37°C to remove traces of RNA from the samples. The cells were then washed in PBS and 25 μL of propidium iodide (1 mg/mL) were added. Samples were analyzed by flow cytometry and gated on the FL2-Width FL2-Area to identify clumps and doublets. Ten thousand events were acquired and apoptotic cells were detected in the 'SUB G1' area of the graph by a FACScalibur cytometer (BD Bioscience, USA). Annexin V binding experiments were performed using the APC Annexin V Apoptosis Detection Kit with propidium iodide (Biolegends, CA, USA). Briefly, 1x106 cells were washed with annexin binding buffer and then incubated with annexin V APC for 15 min at room temperature. Further washing with binding buffer was performed and 5 mL (0.5 mg/mL) of propidium iodide were added before acquisition on the FACScalibur cytometer. Western blots Washed and pelleted cells were lysed in cold RIPA buffer (1 mL/100 mg) containing 10 mM phenylmethylsulfonyl fluoride (Thermo Scientific), a serine protease inhibitor, and centrifuged at ~14,000 x g for 15 min. Supernatant was collected for western blot analysis. The samples were run in 3-(N-morpholino) propane sulfonic acid on acrylamide gels using a Sea Blue marker for size, then transferred to a polyvinylidene fluoride membrane. After transfer, the samples were blocked for 90 min with 5% skim milk solution in PBS-Tween. The membrane was incubated with primary antibody overnight at 4°C and then placed in the secondary antibody solution for 30 min. Electroluminescence was used to detect bands. The antibodies used were purchased from: Abcam (UK) – λ (1:5,000, ab109247 - polyclonal), κ – (1:20,000, ab134083 - polyclonal), c-Myc – (1:10,000, ab152146 - polyclonal), – p62 (1:1000, ab56416 - SQSTM1); Santa Cruz Biotechnology (TX, USA) – Cyclin E (1:200 of 200 mg/mL, SC-247-HE12), – GAPDH (1:400 of 200 mg/mL, SC-25778 -FL335), – Actin (1:5000, 41185 -C4) or Cell Signaling Technology (MA, USA) – Caspase-3 (1:1000, 9665-8G10), – PARP/PARP1 (1:1000, 9542). Exogenous light chain assay Purified LC were obtained as previously described22 from patients' 24 h urine collections. Briefly, human urine samples combined with 0.1% sodium azide (w/v) were centrifuged and ammonium sulphate was added to precipitate the LC which were then solubilized in 20 mM sodium phosphate, pH 7.0, and dialyzed against the same buffer. LC were purified by anion exchange chromatography. MM and non-MM cell lines were seeded in 96-well plates at 10,000 cells/well, in pentaplicate, and LC which were resuspended in medium were added with a pipette at the designated concentrations to medium containing cells, and cultured for 5 days. CellTiter-Glo® (Promega, USA) reagent was added and the luminescence of the plates was read using a Berthold illuminometer (Titertek, Germany). RNA extraction for RNA sequencing We used a Qiagen RNEasy mini kit to extract RNA and tested the quality of the RNA with 6000 Nano Bio analyzer (Agilent Technologies, CA. USA). Transcriptome libraries were prepared using the Illumina TruSeq RNA Library Preparation Kit (Illumina #RS-122-2001), according to the manufacturer's recommended protocol, starting with approximately 1.2 mg of total RNA. The amplified indexed libraries were quantified using an Invitrogen Qubit fluorometer and pooled equally according to the pool design. Pooled libraries were run on a 4% agarose gel and DNA approximately 270 base pairs long (the length of RNA inserts plus the 3′ and 5′ adaptors) was size-selected and recovered in 15 µL elution buffer (QIAGEN). Size-selected libraries were then quantified again using the Qubit Fluorometer. Size was verified using High Sensitive DNA gels on an Agilent 2200 TapeStation instrument. Libraries were sequenced on a NextSeq 500 instrument using the Next-Seq 500 High Output V2 Sequencing Kit (FC-404-2005), in a single-end configuration, reading 80 base pairs. Sequencing and differential expression analysis Raw reads were quality-trimmed at both ends, using inhouse Perl scripts, with a quality threshold of 32. Following quality-trimming, adapter sequences were removed with cutadapt (version 1.9.1, http://cutadapt.readthe docs.org/en/stable/),22 filtering out reads that became shorter than 15 nt (-m parameter). The remaining reads were further filtered to remove very low quality reads, using the fastq_quality_filter program of the FASTX package (version 0.0.14, http://hannonlab.cshl.edu/fastx_toolkit/), with a quality threshold of 20 at 90% or more of the reads' positions. The processed reads were aligned with up to five mismatches per read to the human transcriptome and genome using TopHat (v2.0.14).23 The genome version was GRCh38, with annotations from Ensembl release 84. The genome was slightly modified to include the different transgenic sequences (as additional chromosomes). Raw counts were obtained with the Cufflinks package (v2.2.1),24,25 using the cuffquant program with the genome bias correction (-b parameter) and the multi-mapped reads assignment algorithm (-u parameter), followed by cuffnorm. Normalization and differential expression were achieved with the DESeq2 package (version 1.12.4),26 using default parameters. Functional enrichment analysis Downstream analysis of the expression data was done using two approaches. The first approach used a cut-off (i.e., threshold-dependent). Significantly differentially expressed genes (Padj<0.1) were subjected to pathway and molecular function enrichment analysis using Ingenuity Pathway Analysis (IPA®) (QIAGEN Inc., https://digitalinsights.qiagen.com/products-overview/discovery-insightsportfolio/content-exploration-and-databases/qiagen-ipa/ . The second approach consisted of whole data analysis. Whole differential expression data from amyloidogenic [H] and [K] versus non-amyloidogenic [M] LC-expressing cell lines were subjected to gene set enrichment analysis (GSEA).26 GSEA uses all differential expression data (cutoff independent) to determine whether sets of genes, defined a priori, show statistically significant, concordant differences between two biological states. GSEA was run against the hallmark gene set collection from the molecular signatures database (mSigDB). Signals with normalized enrichment scores of more than 3 or less than -3 were chosen for experimental validation. Oxidative stress measured by flow cytometry One million cells of the JJN3 cell line and its clones were treated with either 3.3 μg/mL MitoSOX (Thermofisher Scientific, USA) or 5 μM dihydroethidium (DHE, Sigma, USA) for 30 min in phenol-free medium. Tetramethylrhodamine methylester perchlorate (TMRM, Molecular Probes, USA) was added to the cell culture (25 nM final concentration) for the last hour of incubation. Following all incubations, cells were washed twice with PBS and then 50,000 cells were acquired and analyzed using a FACScalibur cytometer. MitoSOX measures mitochondrial superoxide while DHE measures total cellular reactive oxygen species. TMRM measures mitochondrial membrane potential. Cholesterol assay The Amplex® Red Cholesterol Assay Kit (Thermofisher Scientific, USA) measures the concentration of both free cholesterol and cholesteryl esters by a coupled enzyme assay, which results in a colorimetric (570 nm)/fluorometric (λex=535/λem=587 nm) product, proportional to the cholesterol present. The assay was performed according to the kit's instructions. MM cells from [K], [H] and [M] lines were seeded at 2 x 106 cells/50 mL of reaction mixture and assayed for free and total cholesterol levels. Cytometric bead assay The BDTM Cytometric Bead Array (BD Bioscience, USA) is a flow cytometry application that allows quantification of multiple cytokines simultaneously. The Cytometric Bead Array system was used to capture cytokines secreted into the supernatant by MM cells, seeded at 1x105/mL, which had been transfected with [K], [H] and [M] LC. The assay was performed according to the kit's instructions. Events were acquired on a FACScalibur and analyzed with Simplify Analysis with FCAP Array v3.0 software and Excel. A standard t test was used to determine statistically significant differences in all experiments not involving RNA assessment and RNA sequencing. Amyloidogenic light chains are toxic to plasma cells Amyloidogenic and non-amyloidogenic MM cell lines were produced from constructs encoding cDNA from 600 patient-specific base pair-sequenced LC that were generated from patients suffering from cardiotoxic [H] and nephrotoxic [K] AL and non-amyloidogenic MM ([M]). LC sequences (Online Supplementary Data File) and functional changes in PC biology and growth were assessed. Multiple transfections were performed from two clones of each LC: [K], [H], and [M]. As an added control, we transduced the MM cell line with a lentiviral vector encoding only GFP [G]. We found that the MM cells (JJN3, KMS11 and NCIH929) which contained cardiotoxic [H] LC and/or nephrotoxic [K] LC had a significantly lower proliferation rate (Figure 2A, data not shown) and significantly more apoptosis/autophagy (Figure 2B-D, data not shown) than the control cell lines ([M] and [G]). The MM cells transduced with nephrotoxic [K] LC had significantly more cells in G0/G1 of the cell cycle and expressed higher levels of the autophagic protein p62 (Figure 2B, E) compared to control cell lines. We assessed the expression of autophagic protein p62 to determine concordance with previously published data. However, the levels of proteins involved in the cell cycle, such as Cyclin E, a protein required for the transition of cells from G1 to S, showed no significant differences between the cell lines (Online Supplementary Figure S2A). Nevertheless, the levels of proteins involved in apoptosis, such as cleaved caspase 3, were increased in the MM cell lines transduced with constructs encoding amyloid LC (Online Supplementary Figure S2A) and these cells showed significantly lower viability, as measured by lower ATP consumption using the CellTiter-Glo® assay (Figure 2D and F, asterisks). Moreover, poly (ADP-ribose) polymerase (PARP), a family of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed cell death, was shown to be highly increased in the MM cells transduced with [K] LC (Online Supplementary Figure S2B, C). To understand the selective mechanism involved in the cell proliferation and death of the cells transduced with amyloidogenic LC, RNA-sequencing analysis was performed on the cells to compare the biological effects of AL LC versus MM LC in MM cell lines. RNA-sequencing analysis of genes involved in autophagy and the intrinsic and extrinsic apoptotic pathways generated heatmaps displaying significant changes in RNA levels when the three cell lines were compared (Online Supplementary Figure S2D), showing that the cell lines containing AL LC had increases in death pathways in line with increases in autophagic protein p62 and apoptosis (Figure 2). FAS ligand RNA levels were upregulated in the JJN3 cell lines transduced with MM LC, whereas caspase-3 and -6 showed trends of RNA upregulation in the cell lines transduced with [K] and [H]. When IPA® Map Activator Prediction analysis was performed, it was found that key genes in the death receptor signaling pathway were either significantly experimentally upregulated or predicted to be upregulated, as calculated from the expression of the measured genes of this pathway by both the AL LC cell lines as compared to [M] (Online Supplementary Figure S2E). The involvement of the autophagic pathway in AL LC toxicity has been reported elsewhere and our results concord with these findings.20 To determine whether the toxicity of the amyloidogenic LC that was seen in the MM cell lines was specific to PC only, the same lentivirus combinations were transduced multiple times into 293T (kidney), HL60 (acute myeloid leukemia) and 721.221 (B lymphocyte) cell lines. We did not observe changes in viability, measured by ATP consumption, or decreases in cell cycle when the LC were produced within the cells (S and G2M, Online Supplementary Figure S1A-C). Transduced amyloidogenic light chains cause a significant increase in stress pathways in multiple myeloma cells Further RNA-sequencing analysis was performed on the cells containing AL LC versus MM LC in order to compare biological effects in the MM cell lines. A gene expression heatmap (Online Supplementary Figure S3A) showed significantly upregulated or downregulated expression of various genes in the MM cells containing AL LC. An IPA® heatmap of the cell death and survival category shows functions that are involved in cell viability and cell death for which significantly enriched differentially expressed genes were found in MM cells that contained amyloid LC (Padj<0.1, Benjamini-Hochberg P<0.05) (Figure 3A, Online Supplementary Table S1). Furthermore, it is interesting to note that functions that are involved in cell death and apoptosis are predicted to be significantly upregulated, while those that are involved in cell viability are predicted to be downregulated, as reflected by IPA® z-scores that are higher than 2 in the former and lower than -2 in the latter. These results validate the phenotypic results shown earlier (Figure 2). In the IPA® heatmap representing small molecule biochemistry, three molecular pathways, 'concentration of ATP', 'metabolism of cholesterol' and 'concentration of D-glucose', are predicted to decrease significantly in the AL LC-containing cell lines (Figure 3B, Online Supplementary Table S2) as compared to MM LC-containing cell lines. Interestingly, 11 significantly differentiated upregulated genes which participate in the oxidative phosphorylation enriched canonical pathway (Benjamini-Hochberg, P<0.05) are upregulated in MM LC-containing cells as compared to the cell lines expressing AL LC (Figure 4A, depicted with pink outline, Online Supplementary Table S3). However, IPA® does not predict activation states of pathways and therefore the upregulation of these 12 genes does not necessarily signify activation of the pathway. We therefore validated this pathway in vitro. Mitochondrial superoxide was measured by flow cytometry in MM cell lines containing AL LC and MM LC. Similarly to data generated by secondary RNA sequencing (Figure 4A), cells expressing AL LC ([H] and [K]) had significantly increased mitochondrial oxidative stress compared to MM cells containing non-amyloidogenic LC [M] (Figure 4B). No change was observed in mitochondrial membrane potential, as analyzed by TMRM. Another well-established method to identify classes of genes whose expression is significantly altered between different states is GSEA. We used GSEA to compare the significant changes in gene set expression from JJN3 MM cells lines that expressed AL LC ([K] and [H]) versus cell lines that contained non-AL MM LC. The analysis found four gene sets with significant differences between the states. Cholesterol homeostasis, TNFα signaling via NFκB an d hypoxia were significantly enriched in the downregulated genes, while the Myc-target gene set was significantly enriched in the upregulated genes in AL LC ([H] and [K]) cells compared to non-amyloidogenic LC [M] (Figure 5A-C). Cholesterol homeostasis was significantly down-regulated in the AL LC JJN3 MM cells and significantly higher levels of both free and total cholesterol were found in the cells transduced with AL LC ([H] and [K]) (Figure 5A). This result indicates a decrease in cholesterol metabolism and homeostasis, confirming the results seen in GSEA. Genes known to be Myc targets or involved in the Myc pathway were shown to be upregulated in the AL LC MM cells and higher levels of Myc protein and RNA itself were found in these cells (Figure 5B, Online Supplementary Figure S3B). TNFa enhances cell invasion via the NFKB pathway and NFKB controls DNA replication, cytokine production and cell survival. Genes involved in TNFa signaling via NFKB were downregulated in the AL LC cells as compared to JJN3 MM LC cells, indicating decreased cell survival and cytokine production of the inflammatory pathway (Figure 5C, Online Supplementary Table S4). Secretion of various cytokines involved in the NFKB pathway was measured in the supernatant of AL LC versus JJN3 MM LC cells using the the Cytometric Bead Array kit. Six cytokine levels were measured simultaneously (IL-8, IL-1\|3, IL-6, IL-10, TNFa and IL-12p70). Concentrations of IL-1\|3, TNFa and IL-12p70 were below the detectable limit of the assay. However, for IL-10, an anti-inflammatory cytokine, concentrations were significantly increased in AL [H] LC cells as compared to MM LC cells. In contrast, levels of the pro-inflammatory cytokines IL-8 and IL-6 were significantly lower in the AL LC-containing cells (P<0.02-0.0002) (Figure 5C). It is worth noting that IL-6 is known to be involved in MM disease progression. These results indicate that the AL LC MM cells have decreased NFKB activity, which could explain the decrease in cell viability, with the interplay balanced between various inflammatory mediators as well. Finally, the gene set associated with hypoxia was found to be significantly downregulated in the AL LC MM cells (Figure 5D). Hypoxia occurs when cells are deprived of adequate levels of oxygen. If the AL LC cells are continuously hypoxic this could contribute to the increased cell death observed in these cells. This effect may be due to the increase in reactive oxygen species causing activation of the hypoxia genes as a secondary stress response. The amyloid PC clone shows a selective high sensitivity to proteasome inhibitor-based therapy, resulting in a high rate of rapid, complete responses.27 In previous studies this exquisite sensitivity was attributed to the oxidative endoplasmic reticulum stress induced by amyloid LC.20,21 Furthermore, the time to next therapy was reported to be ≥7 years in 60% of patients achieving complete remission after bortezomib-based therapy,27 indicating a low proliferative rate of the amyloid clone, as also documented by early studies analyzing the PC labeling index.28 However, the molecular basis of the indolence of the amyloid clone remained undetermined. We hypothesized that the clone size and malignant behavior may be partially influenced by the internal LC proteotoxicity to the diseased PC itself. The amyloidogenic PC in our study were phenotypically different with significant growth arrest compared to their non-amyloidogenic controls (Figure 2). Not only were they less proliferative but, additionally, the cell lines containing AL LC had higher apoptosis and autophagy (Figure 2, Online Supplementary Figure S2) which is compatible with the findings of previous studies.22,29,30 This apoptotic phenomenon was also shown to be a major mechanism of sensitivity to bortezomib in AL cells20 and altering LC balance within the cells may affect AL PC survival.31 In this study, we demonstrate that this sensitivity was a specific internal PC effect and it did not occur in other types of non-PC lines producing AL LC. To further delineate the underlying mechanism of the LC toxicity we subjected the transduced cells to RNA-sequencing analysis. This first revealed that the cells containing AL LC had decreased viability and increased apoptosis (Figure 3, Online Supplementary Tables S1-3, Online Supplementary Figure S3B), which could be due to major pathways involved in the metabolic stability of these cells. Pathways whose genes were significantly changed included the cholesterol pathway, Myc pathway, NFκB signaling, hypoxia and oxidative stress (Figures 3-5). We validated the RNA-sequencing results by measuring the activation of these pathways in vitro and indeed found these to be more active in MM cells transduced with MM LC than in cells transduced with AL LC (Figures 3-5). This is in line with previous studies showing pro-apoptotic cascades and high oxidative stress caused by amyloidogenic LC.20,30,32 RNA levels of key regulators of apoptosis and control of proliferation were found to be significantly increased during the RNA-sequencing analysis. The most significant pathways were validated herein, but many others were not investigated further in this study. Our future plans are to confirm some of these gene functions and effects of exogenous compounds in our novel model in order to delineate even more precisely the significant differences in function between a LC generated by PC from MM versus AL patients, and the amyloidogenic PC phenotype. Here we have shown that a novel model of MM cells expressing AL LC in vitro simulated toxicity in PC and that this toxicity leads to increased apoptosis and decreased proliferation due to the malfunction of key biological processes, thus supporting our hypothesis that the AL clone size and low-grade malignant behavior may be partially influenced by internal LC proteotoxicity to the diseased PC itself. Our novel transduction system may enable future in vitro studies to delineate detailed AL-unique cellular pathways and devise specific targeted treatments for AL amyloidosis. - Received November 29, 2022 - Accepted June 20, 2023 No conflicts of interest to disclose. EL, RH, JB, PR, and MP conducted experiments and analyzed the data. MP, SE, HB, YN, GM, and MEG designed the research and analyzed data. MP and MEG wrote the paper. All authors have read and revised the manuscript. Data-sharing statement All raw RNA-sequencing data can be found online. This work was supported by project grants from the Israel Cancer Association, Bertha Bekhor, Hematology Research Project, Pfizer Global Medical Grant and the Adele and David Brown bequest fund in the name of the Fineberg family The authors thank Dr. Riki Perlman for editing the final version of the article. - Merlini G, Bellotti V. Molecular mechanisms of amyloidosis. N Engl J Med. 2003; 349(6):583-596. https://doi.org/10.1056/NEJMra023144PubMedGoogle Scholar - Obici L, Perfetti V, Palladini G. Clinical aspects of systemic amyloid diseases. Biochim Biophys Acta. 2005; 1753(1):11-22. https://doi.org/10.1016/j.bbapap.2005.08.014PubMedGoogle Scholar - Desikan KR, Dhodapkar MV, Hough A. Incidence and impact of light chain associated (AL) amyloidosis on the prognosis of patients with multiple myeloma treated with autologous transplantation. Leuk Lymphoma. 1997; 27(3-4):315-319. https://doi.org/10.3109/10428199709059685PubMedGoogle Scholar - Madan S, Dispenzieri A, Lacy MQ. Clinical features and treatment response of light chain (AL) amyloidosis diagnosed in patients with previous diagnosis of multiple myeloma. Mayo Clin Proc. 2010; 85(3):232-238. https://doi.org/10.4065/mcp.2009.0547PubMedPubMed CentralGoogle Scholar - Rajkumar SV, Gertz MA, Kyle RA. Primary systemic amyloidosis with delayed progression to multiple myeloma. Cancer. 1998; 82(8):1501-1505. https://doi.org/10.1002/(SICI)1097-0142(19980415)82:8<1501::AID-CNCR11>3.3.CO;2-MGoogle Scholar - Rajkumar SV, Gertz MA, Kyle RA. Prognosis of patients with primary systemic amyloidosis who present with dominant neuropathy. Am J Med. 1998; 104(3):232-237. https://doi.org/10.1016/S0002-9343(98)00037-0PubMedGoogle Scholar - Merlini G, Stone MJ. Dangerous small B-cell clones. Blood. 2006; 108(8):2520-2530. https://doi.org/10.1182/blood-2006-03-001164PubMedGoogle Scholar - Gatt ME, Palladini G. Light chain amyloidosis 2012: a new era. Br J Haematol. 2013; 160(5):582-598. https://doi.org/10.1111/bjh.12191PubMedGoogle Scholar - Palladini G, Merlini G. Current treatment of AL amyloidosis. Haematologica. 2009; 94(8):1044-1048. https://doi.org/10.3324/haematol.2009.008912PubMedPubMed CentralGoogle Scholar - Palladini G, Campana C, Klersy C. Serum N-terminal probrain natriuretic peptide is a sensitive marker of myocardial dysfunction in AL amyloidosis. Circulation. 2003; 107(19):2440-2445. https://doi.org/10.1161/01.CIR.0000068314.02595.B2PubMedGoogle Scholar - Palladini G, Lavatelli F, Russo P. Circulating amyloidogenic free light chains and serum N-terminal natriuretic peptide type B decrease simultaneously in association with improvement of survival in AL. Blood. 2006; 107(10):3854-2858. https://doi.org/10.1182/blood-2005-11-4385PubMedGoogle Scholar - Merlini G, Westermark P. The systemic amyloidoses: clearer understanding of the molecular mechanisms offers hope for more effective therapies. J Intern Med. 2004; 255(2):159-178. https://doi.org/10.1046/j.1365-2796.2003.01262.xPubMedGoogle Scholar - Phipps JE, Kestler DP, Foster JS. Inhibition of pathologic immunoglobulin-free light chain production by small interfering RNA molecules. Exp Hematol. 2010; 38(11):1006-1013. https://doi.org/10.1016/j.exphem.2010.07.001PubMedPubMed CentralGoogle Scholar - Bellotti V, Chiti F. Amyloidogenesis in its biological environment: challenging a fundamental issue in protein misfolding diseases. Curr Opin Struct Biol. 2008; 18(6):771-779. https://doi.org/10.1016/j.sbi.2008.10.001PubMedGoogle Scholar - Baden EM, Sikkink LA, Ramirez-Alvarado M. Light chain amyloidosis - current findings and future prospects. Curr Protein Pept Sci. 2009; 10(5):500-508. https://doi.org/10.2174/138920309789351949PubMedPubMed CentralGoogle Scholar - Arendt BK, Ramirez-Alvarado M, Sikkink LA. Biologic and genetic characterization of the novel amyloidogenic lambda light chain-secreting human cell lines, ALMC-1 and ALMC-2. Blood. 2008; 112(5):1931-1941. https://doi.org/10.1182/blood-2008-03-143040PubMedPubMed CentralGoogle Scholar - Rossi A, Voigtlaender M, Janjetovic S. Mutational landscape reflects the biological continuum of plasma cell dyscrasias. Blood Cancer J. 2017; 7(2):e537. https://doi.org/10.1038/bcj.2017.19PubMedPubMed CentralGoogle Scholar - Huang XF, Jian S, Lu JL. Genomic profiling in amyloid light-chain amyloidosis reveals mutation profiles associated with overall survival. Amyloid. 2020; 27(1):36-44. https://doi.org/10.1080/13506129.2019.1678464PubMedGoogle Scholar - Bochtler T, Merz M, Hielscher T. Cytogenetic intraclonal heterogeneity of plasma cell dyscrasia in AL amyloidosis as compared with multiple myeloma. Blood Adv. 2018; 2(20):2607-2618. https://doi.org/10.1182/bloodadvances.2018023200PubMedPubMed CentralGoogle Scholar - Oliva L, Orfanelli U, Resnati M. The amyloidogenic light chain is a stressor that sensitizes plasma cells to proteasome inhibitor toxicity. Blood. 2017; 129(15):2132-2142. https://doi.org/10.1182/blood-2016-08-730978PubMedGoogle Scholar - Bender S, Ayala MV, Bonaud A. Immunoglobulin light-chain toxicity in a mouse model of monoclonal immunoglobulin light-chain deposition disease. Blood. 2020; 136(14):1645-1656. https://doi.org/10.1182/blood.2020005980PubMedGoogle Scholar - Diomede L, Rognoni P, Lavatelli F. A Caenorhabditis elegans-based assay recognizes immunoglobulin light chains causing heart amyloidosis. Blood. 2014; 123(23):3543-3552. https://doi.org/10.1182/blood-2013-10-525634PubMedPubMed CentralGoogle Scholar - Gatt ME, Takada K, Mani M. TRIM13 (RFP2) downregulation decreases tumour cell growth in multiple myeloma through inhibition of NF kappa B pathway and proteasome activity. Br J Haematol. 2013; 162(2):210-220. https://doi.org/10.1111/bjh.12365PubMedPubMed CentralGoogle Scholar - Dutta-Simmons J, Zhang Y, Gorgun G. Aurora kinase A is a target of Wnt/beta-catenin involved in multiple myeloma disease progression. Blood. 2009; 114(13):2699-2708. https://doi.org/10.1182/blood-2008-12-194290PubMedGoogle Scholar - Mani M, Carrasco DE, Zhang Y. BCL9 promotes tumor progression by conferring enhanced proliferative, metastatic, and angiogenic properties to cancer cells. Cancer Res. 2009; 69(19):7577-7586. https://doi.org/10.1158/0008-5472.CAN-09-0773PubMedPubMed CentralGoogle Scholar - Subramanian A, Tamayo P, Mootha VK. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005; 102(43):15545-15550. https://doi.org/10.1073/pnas.0506580102PubMedPubMed CentralGoogle Scholar - Manwani R, Cohen O, Sharpley F. A prospective observational study of 915 patients with systemic AL amyloidosis treated with upfront bortezomib. Blood. 2019; 134(25):2271-2280. https://doi.org/10.1182/blood.2019000834PubMedGoogle Scholar - Gertz MA, Kyle RA, Greipp PR. The plasma cell labeling index: a valuable tool in primary systemic amyloidosis. Blood. 1989; 74(3):1108-1111. https://doi.org/10.1182/blood.V74.3.1108.bloodjournal7431108Google Scholar - Witzig TE, Timm M, Larson D. Measurement of apoptosis and proliferation of bone marrow plasma cells in patients with plasma cell proliferative disorders. Br J Haematol. 1999; 104(1):131-137. https://doi.org/10.1046/j.1365-2141.1999.01136.xPubMedGoogle Scholar - Diomede L, Rognoni P, Lavatelli F. Investigating heart-specific toxicity of amyloidogenic immunoglobulin light chains: a lesson from C. elegans. Worm. 2014; 3(3):e965590. https://doi.org/10.4161/21624046.2014.965590PubMedPubMed CentralGoogle Scholar - Zhou P, Ma X, Iyer L. One siRNA pool targeting the lambda constant region stops lambda light-chain production and causes terminal endoplasmic reticulum stress. Blood. 2014; 123(22):3440-3451. https://doi.org/10.1182/blood-2013-10-535187PubMedGoogle Scholar - Mishra S, Joshi S, Ward JE. Zebrafish model of amyloid light chain cardiotoxicity: regeneration versus degeneration. Am J Physiol Heart Circ Physiol. 2019; 316(5):H1158-H1166. https://doi.org/10.1152/ajpheart.00788.2018PubMedPubMed CentralGoogle Scholar Data Supplements Figures & Tables Article Information This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Easy Squirrel Craft for Kids (FREE Template) This paper bag squirrel craft is great project for kids of all ages. (Yes, even young children like preschoolers and kindergarteners can do it with some adult supervision!) Our cute squirrel craft is the perfect activity for keeping those little hands busy while simultaneously improving their fine motor skills. I'm not sure why it's taken me this long to share a squirrel craft with you all because these little creatures have always been one of my favorite woodland animals. When I went to college in Massachusetts, the squirrel should have been our school's mascot. They were everywhere (including getting into your room if you live by a tree on the 3rd floor). Some little scamps would get into the trash cans and not be able to get themselves out. Then an unsuspecting person would come by to throw their trash out, and the squirrel would come jumping out. I don't know who was more traumatized…the squirrel or the person. Here are a few fun facts about Squirrels - Squirrels are born blind and completely helpless. - Chipmunks are part of the squirrel family. - They are masters at burying and finding their "treasure" (aka acorns), finding it even beneath a foot of snow. - To get through the winter months, squirrels bulk up in weight and live off of their cached food stores. - Squirrels can leap 10x their body height. - They can run up to 20 miles per hour. Learn even more interesting things about squirrels in this article by Cool Kid Facts. Save this Easy Animal Craft for later. Pin it to your favorite Pinterest board… All activities require adult supervision. By using this site, you are agreeing to our terms of use. This post contains affiliate links, which means if you make a purchase through these links, I may receive a small commission at no extra cost to you. Click here to read my full disclosure policy. - Paper bag - Construction paper - Pencil - Scissors - Scotch tape - Glue stick - Markers - Newspaper - Squirrel craft template Crafting with your kids is invaluable, but we so often don't take the time out to just create together. But why? I know all of the excuses (because I've given them myself). So, I have a plan to help… I pledge to keep the crafts simple so that they can actually be completed by children (not a grown up while kids just watch). Secondly, I promise to stick to our master list of supplies for all of the crafts on this site and in our kids' crafts eBooks. Fill your bag, and your prep is done. It's as simple as that! 🙂 Squirrel Craft Instructions Step 1: Use the Squirrel Craft Template - Print out the free squirrel template. You can print onto regular paper or directly onto the brown construction paper directly. If you print onto the construction paper, cut it down to the 8 1/2 x 11-inch size to fit properly. - (We used brown to match the paper bag, but you can also use red to make a red squirrel or grey for a grey squirrel.) - Cut out all of the template pieces. Step 2: Start the Assembly of Your Squirrel - Use the glue stick to attach the arms to the each of long edges of the brown paper bag. - Then attach its bushy tail. Step 3: Stuff Your Squirrel - Crumple up some strips of newspaper and fill the paper bag. Be sure to leave some room for the bag to close. Step 4: Close Up Your Paper Bag Squirrel Craft - Pinch the top of the paper bag closed and secure it with tape. Step 5: Attach the Squirrel Head - Attach the front of the squirrel's head using tape. - Then glue the back of the head in place, sandwiching the closed top of the paper bag. (This step is optional) - Add details to the squirrel's body using your markers. Step 6: Finish Off Your Squirrel Craft - Glue the squirrel's feet to the bottom of the paper bag. - Next, glue the acorn so that it is being held by his hands. - Use the markers to add any other details you like to finish off your paper squirrel craft. How Can You Customize Your Squirrel Craft? Now that you know how to make a squirrel craft, what will you do with it? Maybe you can make him some friends, like this adorable fluffy bunny and a little mouse or maybe someone from another climate, like this paper bag penguin craft. Add details to your squirrel that make him unique, just like you. Honestly, the only limit is your imagination. Feel free to use other supplies from your bag, like googly eyes, or a pom-pom nose. Maybe your little squirrel a pinecone instead of an acorn – the choice is yours! What Paper is Best for Making Your Paper Squirrels? We used a heavy construction paper for our squirrel craft. It's one of the 27 items from the master list that we always keep in our craft bag. However, if you don't have pink construction paper, you can also use regular printer paper that you color with crayons, card stock or scrapbooking paper instead. More Animal Crafts for Kids to Make - Llama Craft - Kangaroo Craft - Ocean Animal Crafts - Skunk Craft - Tiger Craft - Giraffe Craft - Clothespin Animals (Tiger, Unicorn and Zebra) - Wiggly Eared Dog Craft - Axolotl Craft Puppet - Sleeping Deer Craft - Paper Bag Cats - Paper Bag Owl Crafts - Fluffy Bunny Craft - Sleeping Cat Craft - Clothespin Porcupine Craft
When we started our operations in 2018, we thought that one way we could make a meaningful impact was through teaching foreign languages to children in underserved communities. However, we realize that many of these children could not read or write in Spanish even though they were attending school. The Literacy+ program is an adapted version of the Pratham organization's Teaching at the Right Level (TaRL) methodology in India catered to Colombia's context. With this methodology, basic reading, writing and math skills are evaluated and improved in school-aged children. In 2020, we transformed the program and created the Literacy+ kit, with which we can reach rural areas that are without internet access. Each Literacy+ Kit contains: We know that measuring our impact is important and that many people talk about it. WE measure our impact with the simplicity of an ALPHABETIC APPROACH. We undertake a sustainable approach with everything that we do by conforming to the United Nations SDGs framework. We do so by ensuring that language. The mission and vision of our network is directly related to these SDGs: Access impact reports
Are you looking to become a bank manager and need some help with creating your resume? Our Bank Manager Resume Example article is here to help! It will provide you with a comprehensive look at what a successful bank manager resume should look like, including tips on how to craft an eye-catching resume that will grab the attention of recruiters. Read on to learn more about how you can create a winning resume! We will cover: - How to write a resume, no matter your industry or job title. - What to put on a resume to stand out. - The top skills employers from every industry want to see. - How to build a resume fast with our professional Resume Builder. - What a resume template is, and why you should use it. What does a Bank Manager do? A Bank Manager is responsible for overseeing operations at a financial institution, such as a bank, credit union, or building society. This includes ensuring compliance with regulations, analyzing financial data, implementing strategic plans, and managing customer service. Bank Managers also handle customer inquiries, provide advice on financial products and services, and supervise staff. Additionally, they may be responsible for developing relationships with business partners and implementing marketing plans. - Business Owner Resume Sample - Business Partner Resume Sample - CEO Resume Sample - Chairman Resume Sample - Captain Resume Sample - Front End Manager Resume Sample - Director Of Logistics Resume Sample - Chief Of Staff Resume Sample - Deputy Director Resume Sample - Call Center Manager Resume Sample - Call Center Operations Manager Resume Sample - Director Of Product Management Resume Sample - Bank Manager Resume Sample - Banking Manager Resume Sample - Branch Manager Resume Sample - Dental Office Manager Resume Sample - Activity Director Resume Sample - Benefits Manager Resume Sample - Compliance Manager Resume Sample - Director Of Human Resources Resume Sample What are some responsibilities of a Bank Manager? - Manage daily operations of the bank - Develop and implement bank policies and procedures - Develop strategies to increase customer base - Oversee customer service staff - Monitor and analyze financial data - Ensure compliance with banking regulations - Develop marketing plans to promote banking products and services - Manage and motivate staff - Negotiate contracts with vendors and suppliers - Identify risk management issues and implement solutions Sample Bank Manager Resume for Inspiration Name: John Smith Address: 123 Main Street, Sydney, NSW 2000 Email: email@example.com Phone: +61 (0)2 9999 9999 John Smith is an experienced Bank Manager with a proven track record of success in the banking and finance industry. He has an in-depth understanding of the banking and finance industry, excellent customer service skills and an ability to work with a diverse range of clients and colleagues. John is highly motivated and committed to providing excellent service to his clients and customers. Work Experience: - Banking Manager, Bank of Australia, Sydney, NSW (2019 – Present) - Managed the daily operations of the bank, including customer service, sales, and loan processing - Developed and implemented strategies to increase customer satisfaction and enhance efficiency - Provided financial advice to clients and oversaw loan applications - Senior Bank Officer, Bank of Australia, Sydney, NSW (2013 – 2019) - Provided customer service and sales support to customers - Processed loan applications and managed customer accounts - Assisted in developing new strategies and procedures to improve customer service and operational efficiency - Bachelor of Business Administration, University of Sydney, Sydney, NSW (2009 – 2013) - Customer Service - Sales - Operational Efficiency - Financial Advice - Loan Processing - Certified Financial Adviser, Financial Advisory Board, Sydney, NSW (2013) - English (Native) - Spanish (Intermediate) Resume tips for Bank Manager Creating a perfect, career-launching resume is no easy task. Following general writing rules can help, but it is also smart to get advice tailored to your specific job search. When you're new to the employment world, you need Bank Manager resume tips. We collected the best tips from seasoned Bank Manager - Check out their advice to not only make your writing process easier but also increase your chances of creating a resume that piques the interest of prospective employers. - Highlight key accomplishments and skills in the summary section. - Include specific data and results to demonstrate impact. - List relevant experience in reverse chronological order. - Include certifications and professional development achievements. - Proofread and edit to remove any spelling or grammar mistakes. Bank Manager Resume Summary Examples Using a Bank Manager Resume Summary or Resume Objective is important to effectively communicate your qualifications and expertise to potential employers. A Bank Manager Resume Summary or Resume Objective is a concise overview of your qualifications, experience and skills as they relate to the position you are seeking. It should be tailored to the specific job and highlight your most relevant experience and qualifications. It also gives potential employers an idea of what you have to offer and the value you can bring to the position. For Example: - Experienced bank manager with 8 years of experience in managing customer service and financial operations. Skilled in providing superior customer service, and client relations. - Dedicated bank manager offering 12 years of expertise in overseeing financial operations and customer service. Proven record of achieving customer satisfaction and loyalty. - Efficient bank manager with 10 years of experience in managing banking operations and customer service. Expert in developing cost effective strategies and providing superior customer service. - Highly skilled bank manager with 15 years of experience in financial operations and customer service. Proven success in achieving customer satisfaction and building strong client relationships. - Dynamic bank manager with 5 years of experience in providing excellent customer service and financial operations. Skilled in developing cost effective strategies and achieving customer satisfaction. Build a Strong Experience Section for Your Bank Manager Resume Building a strong experience section for a bank manager resume is important because it allows you to showcase your skills, abilities and accomplishments to potential employers. It also provides a snapshot of your professional background and qualifications that demonstrate to employers that you are the ideal candidate for the position. A strong experience section can help potential employers understand the scope of your work, the challenges you have overcome and the results you have achieved in your previous roles. Additionally, a well-written experience section can help you stand out among other applicants and give you a competitive edge in the hiring process. For Example: - Managed a team of 10 loan officers and customer service representatives in a high-volume retail banking environment. - Provided effective leadership and guidance to ensure the highest levels of customer service and customer satisfaction. - Developed and implemented processes and procedures to ensure compliance with all banking regulations. - Monitored and evaluated loan performance, credit risk and portfolio management. - Handled customer inquiries and complaints in a timely and professional manner. - Reviewed and recommended changes to loan products and services. - Developed and maintained relationships with business partners to increase sales and profitability. - Analyzed customer data and identified opportunities to improve customer retention. - Created and implemented strategies to increase efficiency and reduce operational costs. - Maintained accurate records and reports to ensure the bank's compliance with all applicable laws and regulations. Bank Manager resume education example A Bank Manager typically needs a bachelor's degree in banking, finance, accounting, business administration, economics, or a related field. Depending on the employer, some employers may also require additional certifications or a master's degree. Management experience may also be preferred for some positions. Here is an example of an experience listing suitable for a Bank Manager resume: - Bachelor of Science in Business Administration, University of Southern California, Los Angeles (2007) - Master of Science in Banking and Financial Management, University of California, Berkeley (2009) - Certified Financial Planner (CFP) by Financial Planning Association (2011) Bank Manager Skills for a Resume Adding skills to a Bank Manager resume is important because it serves as a way to demonstrate your qualifications and areas of expertise to potential employers. It also helps employers to quickly identify whether or not you meet the job requirements. Examples of skills that should be included on a Bank Manager resume include financial management, customer service, operations management, risk management, strategic planning, and regulatory compliance. Soft Skills: - Leadership - Management - Business Acumen - Communication - Decision Making - Problem Solving - Organizational - Planning - Customer Service - Collaboration - Financial Management - Risk Management - Banking Regulations - Investment Strategies - Budgeting - Accounting - Customer Service - Leadership - Data Analysis - Credit Risk Common Mistakes to Avoid When Writing a Bank Manager Resume In this competitive job market, employers receive an average of 180 applications for each open position. To process these resumes, companies often rely on automated applicant tracking systems, which can sift through resumes and eliminate the least qualified applicants. If your resume is among the few that make it past these bots, it must still impress the recruiter or hiring manager. With so many applications coming in, recruiters typically give each resume only 5 seconds of their attention before deciding whether to discard it. Considering this, it's best to avoid including any distracting information on your application that could cause it to be thrown away. To help make sure your resume stands out, review the list below of what you should not include on your job application. - Not including a cover letter. A cover letter is a great way to explain why you are the best candidate for the job and why you want the position. - Using too much jargon. Hiring managers do not want to read a resume full of technical terms that they do not understand. - Omitting important details. Make sure to include your contact information, educational background, job history, and any relevant skills and experiences. - Using a generic template. Take the time to customize your resume to the job you are applying for. This will show the employer that you are serious about the position. - Spelling and grammar errors. Always double-check your resume for typos, spelling mistakes, and grammar errors. - Focusing too much on duties. Make sure to include accomplishments and successes to show the employer that you are a great candidate. - Including personal information. Avoid including any personal information such as age, marital status, or religious beliefs. Key takeaways for a Bank Manager resume - Highlight achievements such as successful turnaround and cost savings initiatives. - Detail experience leading teams, setting goals, and exceeding expectations. - Demonstrate fluency in financial products, banking regulations, and risk management. - Describe expertise in customer service, problem-solving, and decision-making. - Provide evidence of strong communication and interpersonal skills. - Showcase expertise in developing and implementing strategies. - Highlight a track record of developing and maintaining relationships with stakeholders. It's time to begin the job search. Make sure you put your best foot forward and land your next job with the help of Resumaker.ai.
Incentive programs play a crucial role in driving employee performance and customer loyalty. These programs are designed to motivate individuals to achieve specific goals through rewards and recognition. However, it is vital for organizations to evaluate the effectiveness of their incentive programs to ensure that they are yielding the desired outcomes. By effectively evaluating incentive programs, organizations can determine their impact on employee engagement, productivity, and customer satisfaction. In this essay, we will explore various methods and metrics to evaluate the effectiveness of incentive programs. In today's competitive business landscape, organizations are constantly seeking ways to motivate and engage their employees. One popular method employed by many companies is the implementation of incentive programs. These programs aim to reward employees for their hard work, boost morale, and ultimately improve overall performance. However, it is essential for organizations to evaluate the effectiveness of these incentive programs to ensure that they are yielding the desired results. In this article, we will explore various methods that can be used to evaluate the effectiveness of an incentive program. Before evaluating the effectiveness of an incentive program, it is crucial to establish clear objectives and define relevant metrics. These objectives should align with the overall goals of the organization and the specific outcomes expected from the incentive program. For instance, if the objective is to increase sales, the metrics could include the number of sales made, revenue generated, or customer satisfaction ratings. By setting clear objectives and metrics, organizations can effectively measure the impact of the incentive program on desired outcomes. Key takeaway: To evaluate the effectiveness of an incentive program, organizations should set clear objectives and metrics that align with overall organizational goals, collect quantitative and qualitative data to analyze the program's impact, compare performance metrics before and after implementation, and conduct a cost-benefit analysis to determine the program's return on investment. To evaluate the effectiveness of an incentive program, organizations need to collect quantitative data. This data can provide valuable insights into the program's impact on various performance indicators. For example, if the incentive program aims to increase productivity, organizations can track metrics such as the number of tasks completed, time taken to complete tasks, or overall output. By analyzing this quantitative data, organizations can determine whether the incentive program has led to improvements in the desired areas. In addition to quantitative data, organizations should also gather qualitative data through surveys and interviews. Surveys can be distributed among employees to collect their opinions, feedback, and perceptions regarding the incentive program. This can help organizations gauge employee satisfaction, engagement levels, and identify any areas for improvement. Similarly, conducting interviews with employees can provide deeper insights into their experiences and the effectiveness of the program. By combining both quantitative and qualitative data, organizations can obtain a comprehensive understanding of the incentive program's impact. One effective method of evaluating the effectiveness of an incentive program is by comparing performance metrics before and after its implementation. By analyzing data from the pre-implementation period, organizations can establish a baseline for comparison. They can then analyze data from the post-implementation period to determine if there have been any significant improvements in performance. This method allows organizations to assess whether the incentive program has had a positive impact on employee motivation and overall performance. Another crucial aspect of evaluating the effectiveness of an incentive program is analyzing the return on investment (ROI). Organizations need to assess whether the benefits derived from the incentive program outweigh the costs associated with its implementation. ROI can be measured by comparing the financial gains achieved through the incentive program with the expenses incurred. By conducting a cost-benefit analysis, organizations can determine if the incentive program is generating a positive return on investment and if it is a sustainable initiative. An incentive program evaluation is a process of assessing the effectiveness and efficiency of an incentive program to determine its impact on the desired behaviors or outcomes. It involves collecting and analyzing data to measure the program's successes, failures, and overall value, helping organizations make informed decisions on program improvements or modifications. Evaluating the effectiveness of an incentive program is crucial because it provides valuable insights into whether the program is achieving its intended goals and objectives. This assessment helps organizations understand if the program is worth the investment, whether it is motivating and driving the desired behaviors or results, and if any adjustments or changes are needed for better outcomes. Effective evaluation enables organizations to optimize their incentive programs and optimize resources for maximum impact. When evaluating an incentive program, several key metrics can be considered. These may include but are not limited to participation rates, goal achievement rates, productivity gains, sales or performance increases, customer satisfaction, employee engagement levels, and the return on investment (ROI) of the program. By assessing these metrics, organizations can gauge the program's impact on various aspects of their operations and determine if the program is effectively driving the desired behaviors and outcomes. Several evaluation methods can be used to assess the effectiveness of an incentive program. These methods may include surveys or questionnaires to gather feedback from program participants, conducting interviews or focus groups to gain qualitative insights, analyzing data from performance metrics, comparing pre-program and post-program measurements, and conducting cost-benefit analyses. Employing a combination of these evaluation methods can provide a comprehensive understanding of the program's effectiveness and identify areas for improvement. Feedback from participants is invaluable when evaluating an incentive program. It provides firsthand insights into their experiences, perceptions, and the effectiveness of the program's incentives and rewards. By obtaining feedback, organizations can identify strengths and weaknesses, understand participant engagement levels, and gather suggestions for program enhancements. This feedback also aids in ensuring that the incentives align with participants' motivations and preferences, increasing the chances of achieving desired outcomes. Evaluating the effectiveness of an incentive program comes with its share of challenges. Some potential obstacles include identifying appropriate metrics that align with program goals, collecting accurate and reliable data, dealing with biases or subjective perceptions, measuring the impact accurately, and attributing changes solely to the incentive program. To overcome these challenges, organizations should carefully plan their evaluation methodology, employ multiple data sources, establish control groups where applicable, and account for other factors that may influence desired outcomes. The frequency of evaluating an incentive program can vary depending on the program's duration, complexity, and objectives. In general, it is recommended to evaluate the program at regular intervals throughout its implementation to track progress, identify areas for improvement, and make necessary adjustments promptly. Evaluations can be conducted annually, quarterly, or even monthly, depending on the organization's resources and the program's significance. Regular evaluations ensure that the incentive program remains effective and aligned with the organization's evolving needs and goals.
Bonding, which likewise conceals tooth discolorations, is when a thin finish of composite product is put on the front of a person's teeth and afterwards cured with a blue light. These tones figure out the effectiveness of the lightening procedure, which might vary from 2 to 7 tones. These tones may be reached after a solitary in office consultation, or may take much longer, depending on the person. The impacts of bleaching can last for a number of months, but might differ depending on the way of living of the client. Consuming tooth staining foods or beverages that have a strong colour might compromise efficiency of the therapy. The Teeth Whitening Toothpaste Australian Influencers Love. Posted: Tue, 26 Jul 2022 07:00:00 GMT [source] Tartar, plaque and also other debris restrain the impact of the whitening treatment. Your exam will give your dental practitioner time to identify whether their expert treatment is ideal for your stains. While spots from food, drinks, as well as tobacco are easily removable, some stains triggered by medication or condition call for even more extreme procedures. Since teeth whitening has actually been around for some time as well as is readily available in your regional drug store as well as supermarket, we neglect that it's an aesthetic treatment. In-office teeth lightening, consisting of information regarding the procedure, its expenses as well as your different lightening alternatives. Throughout an office check out, the dental practitioner takes very outlined perceptions of the teeth as well as gumline. Based on those impressions, vinyl trays having bleaching-gel tanks are custom-fabricated. Looking like the aligners used in modern orthodontics, these trays give an unique fit that presses right approximately the gumline. The purpose is to maintain the lightening gel secured inside, thus protecting against gum irritability and also the mixing of saliva with the gel. You typically require to use the tray either during the day for 2 to 4 hrs or over night, relying on the product. Proceed this for concerning 2 Highland dental specialists weeks typically, yet perhaps for 4 to 6 weeks. Costs for at-home whitening systems per arc variety from $175 to $450. You will have the trays and also gel in your mouth for 20 minutes. These medications chemically bind with the crystalline structure of both the tooth's enamel and also underlying dentin. Not all treatments or solutions defined are covered benefits for Kaiser Permanente members or supplied as solutions by Kaiser Permanente. For a list of protected advantages, please describe your Proof of Insurance Coverage or Recap Strategy Description. So practically speaking, any type of product that is made use of to clean the teeth is taken into consideration a whitener. Certainly, the term bleaching seems far better than whitening, so it is much more frequently utilized-- even when explaining products which contain bleach. I was instructed to use my personalized tray as well as use a lower dose of peroxide on my teeth for 30 minutes for 7 days directly post-procedure to preserve the appearance of my icy whites.
A career by design Exhibition shines spotlight on low-profile Tong Jun's key contribution to the architectural community, Zhang Kun reports. By Zhang Kun \| China Daily \| Updated: 2023-03-24 08:33 In the last few years of his life, Tong Jun suffered from a cancer relapse, and this left him in despair as it meant he could not complete the work he had set out to do, says his grandson. Tong Jun and his aesthetic analysis of classical Chinese gardens influenced many important architects. According to Wang Shu, China's first Pritzker Architecture Prize winner (widely considered the Nobel Prize for architecture), Tong Jun's argument that "taste, be it emphasized, counts here much more than mere know-how", and that's a key point in his own architectural theory. Wang says, inspired by Tong Jun, he was able to break the boundary between architecture and gardens in his designs.
Alcohol addiction will be overwhelming as it affects lives. Nevertheless, well timed diagnosis of the condition and a proper treatment plan at a rehabilitation middle can save lives. Rehabilitation includes identifying the undermendacity problem of the affected person and providing a specific therapy plan that deals with the root cause of the problem. Drug and alcohol rehab facilities not only provide the medical assistance to beat addiction, additionally they provide the right atmosphere for a person to do so. By the correct atmosphere, we imply that an surroundings that is free of triggers and promotes recovery. How are alcohol rehabilitation facilities structured? One of the primary advantages of visiting a rehabilitation center is its structure. A therapy program at a rehab heart focuses on routines full of productive activities and counseling sessions that enable patients to focus on recovery. The central emphasis is on patients learning techniques to cope with triggers, relationships, and their own bodily needs. They're inspired to share their emotions in either group or particular person classes with their therapist thereby acknowledging and accepting their emotions and learning to cope with them. Individuals addicted to alcohol, medicine or some other substance develop behaviors or mindset that stop them from accepting healthier habits. A routine is essential for such people to transform self-harmful habits into positive, healing ones. Rehab centers emphasize on a day by day routine customized to suit the person's needs. Following such a routine helps the patient construction their day and addecide healthy way of life changes. How do rehabilitation facilities provide a safe and supportive atmosphere? Addiction therapy rehab centers supply patients a safe, managed, and supportive environment. In addition they help patients meet and interact with folks facing related challenges related with addiction. Peer support is a crucial aspect of treatment. Patients are known to turn to their friends of their weak moments even after recovery. The encouragement and assist obtained from their friends help them preserve long-time period sobriety. Rehabilitation programs in hospitals or outpatient clinics provide many opportunities for networking and building assist networks with others recovering through self-assist groups and group therapy. These individuals assist each other overcome difficulties encountered alongside the way. Most significantly, the help group understands what it means to struggle craving, survive trauma, and feel the load of the shame and guilt of addiction. Having a peer assist group provides the affected person a sense of responsibility and encouragement, as well as an opportunity to help others. How do rehabilitation centers plan their treatment and therapy? Addiction impacts a person both mentally and physically. It can be crucial for therapists to understand the emotional causes of drug use and the best way to assist patients deal with these emotional causes. Therapists may help patients determine deficiencies in thinking and habits that can lead to negative decisions. Effective treatment from therapists, counselors, and peers encourages the affected person to indulge in positive thinking and behaviors to become more productive. They also encourage them to adapt a healthy lifestyle, reducing the patient's likelihood to relapse and helping in transition. In the event you loved this article and you would like to receive more info concerning sober living kindly visit our own site.
Curriculum Overview How we teach...... A solid foundation for your child's future... Curriculum Intent At Twickenham Primary Academy we recognise the importance of securing knowledge, rehearsing that knowledge and working hard to become confident and resilient thinkers and learners. At Twickenham Primary Academy, children will experience a learning environment that will equip them to be successful in a rapidly changing world. They will learn to be resilient, creative and have a growth mindset. They will learn that struggle and challenge are vital parts of the learning process and will be able to cope with, and adapt to, change. They will have sequential learning and hands-on experiences and we will continue to foster the natural insatiable curiosity that they are born with into sustaining a lifelong love of learning. This will start right from our reception classes and continue into Year 6. Our curriculum is broad and our commitment to building firm foundations and encouraging academic mastery is unswerving. We work on the premise that great teaching; based on formative assessment; great questioning; AfL and retrieval practice, is key. Precise assessment, teaching that closes any gaps and thinking about ability differently are all part of our approach. Our curriculum is well-planned, progressive and sequenced effectively to ensure pupils know more - do more – remember more. We intend that each child challenges themselves every day, taking risks, learning from mistakes and persevering towards their most ambitious goals. Our children will be encouraged to aim as high as they can whilst also enjoying their childhood and benefiting from a variety of broad opportunities and experiences. Our curriculum and approach to learning and teaching has been designed to meet the needs of our pupils. Our intention is that children are taught to read, write and use mathematical skills from their individual starting point as rapidly as possible. We have high expectations for all our children. We engage interest and provide vocabulary in context to support all learners (especially SEND and EAL). We provide clear retrieval and instructional practice to ensure learning 'sticks' by building neural pathways and schema in the long-term memory. We intend that our curriculum is ... · a curriculum where all children are able to learn and are successful and make as much progress as possible · a curriculum that provides the children with the knowledge and skills to know more, remember more and do more · a curriculum that prepares children for the next stages of education and life in society · a flexible curriculum that assesses progress and provides intervention for both academic and emotional needs Our Curriculum delivers the National Curriculum 2014 and beyond. It is designed to be exciting for children and staff with stimulating topics which the children become fully absorbed. It enriches our children as learners and leaders for the future, offering them unique, bespoke opportunities over their seven-year primary journey and preparing them for the future. High-quality texts lie at the heart of the school's curriculum and these are used to engage children in the topic at hand. We model and scaffold the children as learners so that they are able to know how to make the right choices for them to ensure they have the chance to excel. We do not have fixed ability groups, instead all learners are able to access more support or more challenges depending on the topic or subject being studied. Interwoven throughout our Curriculum are the British Values and SMSC (Spiritual, Moral, Social and Cultural) development of our children. Our weekly celebration assembly ensures we celebrate all of our children's effort achievement both inside and outside school. We hold House Days where different year groups learn together in their House groups and work collaboratively on project-based learning. External workshops are held and children have access to experts who enrich their experience. Our year 6 House Captains are instrumental in helping to organise our House events before and during the day. Once a term each class is taken out of the school on a visit directly linked to what they have been learning about in the classroom. We believe in 'learning for life' and this can be seen throughout our curriculum and in books and through discussions with pupils. Through our approach, children at Twickenham Academy achieve highly. Our curriculum and environment fosters pupils who are respectful, polite, and honest and contribute to the community in a positive manner. As a school, we are determined that our children will leave us as confident, ambitious and independent young people, ready for the next stage in their education and we work closely with secondary schools to ensure a smooth transition. Our teachers continually use assessment of the children's responses and the work they produce to measure impact. A regular programme of monitoring, evaluation and review is in place. This includes book scrutinies, learning walks and lesson observations to measure the impact of teaching and learning, as well as pupil voice to gauge children's engagement and enjoyment of the curriculum. Teachers and leaders also have the school's curriculum assessment data to support judgements on the impact our curriculum is having. Curriculum enrichment At TPA we believe that the academic life of our pupils and staff should include much more than what happens in the mainstream curriculum. As our school day runs longer than most, we are able to offer a wide range of experiences and challenges that enrich our curriculum. This is to ensure that our pupils are inspired to learn outside of the classroom and develop the skills required for the world beyond their primary education. All children at TPA have access to a wide range of after school and in school clubs that enrich and enhance their learning across the curriculum. Furthermore, each year group organises a variety of enrichment activities and experiences over the course of the academic year to extend pupils learning and experiences of a modern British society. Subject leaders develop activities that provide whole school enrichment and collaborative working across year groups. Enrichment events and events to promote cultural capital are shared with parents through our website and newsletters. Our learning environment Our classroom environments both support and enrich the learning of all children. As well as being vibrant and welcoming, the classroom environment is a learning resource, the second teacher, a way of engaging children and building the class community. Our classrooms create a sense of ownership and are used to support and promote learning, as well as celebrating children's work. We use the classroom environment as an interactive resource which supports teaching, learning and assessment. Our working walls show clear progression and are reference points for our pupils. At Twickenham Primary Academy, we believe that a well organised and stimulating environment has a direct impact on the quality of teaching and learning, and therefore supports raising standards. It enables pupils to develop independence as learners, building on good Foundation Stage practice and moving beyond. We provide consistent expectations for all pupils in order to support them, whilst challenging them to give their very best. We develop a shared sense of what high standards look like
Photography under extreme weather conditions can transform an ordinary scene into a stunning spectacle. Whether it's capturing the ferocity of a storm, the elegance of a snow-blanketed landscape, or the drama of a desert at high noon, extreme weather offers unique opportunities for powerful imagery. However, these conditions also pose significant challenges, not only for capturing compelling images but also for protecting equipment and ensuring the photographer's safety. This article provides practical advice for photographers like Leonardo Gusmão Araújo, who often venture into unpredictable environments to capture their breathtaking shots. Understanding and Preparing for Weather Conditions Research and Planning Before heading out, it's crucial to thoroughly research and understand the weather conditions you will be facing. Use weather apps and websites to track weather patterns and alerts. Knowing the forecast can help you prepare for the specific challenges of the day, whether that's extreme cold, heat, rain, or wind. Gear Preparation Protecting your camera and lenses from extreme conditions is paramount. Use weather-sealed camera bodies and lenses when possible. For additional protection, consider using rain covers or even makeshift protections like plastic bags secured with rubber bands. In cold weather, keep spare batteries warm by storing them close to your body, as cold can drain battery life rapidly. Techniques for Different Weather Conditions Capturing Rain and Storms Rain and storms can add a dramatic element to your photos. To capture rainfall, use a fast shutter speed. This freezes the raindrops, creating a sharp image of the rain in action. For a softer, more ethereal effect, a slower shutter speed will turn the rain into elegant streaks across the frame. Lightning photography requires patience and safety precautions. Use a tripod and set your camera to a long exposure to capture multiple strikes. Always ensure you are a safe distance from the storm, preferably shooting from shelter. Snow and Ice Photography Snow and ice alter the landscape dramatically, offering a clean, minimalist canvas. However, snow's brightness can trick your camera's meter into underexposing the scene. Compensate by adjusting the exposure value (EV) settings on your camera. For ice, focus on capturing textures and reflections, which can convey the cold environment vividly. High Winds High winds can be challenging, especially when they carry dust or debris. Secure your camera on a sturdy tripod and weigh it down if necessary. High winds can also create dynamic patterns in sand, snow, or grasses; use a slower shutter speed to capture these movements, or a faster one to freeze tumultuous scenes. Extreme Sunlight Photography in extreme sunlight, such as in desert environments, involves managing harsh shadows and bright highlights. Use a polarizing filter to reduce glare and enhance the blue of the sky against stark landscapes. Shooting during the golden hours—early morning or late afternoon—can also mitigate the harsh midday sun, softening the light for more flattering, dimensional exposures. Safety First No photograph is worth risking your safety. In extreme weather, be prepared with the appropriate clothing and gear. For cold climates, layer up with thermal wear and use hand warmers. In hot conditions, wear light, breathable clothing and stay hydrated. Always have a plan for quick shelter if the weather becomes hazardous. Post-Processing Tips Post-processing is particularly important when shooting in extreme weather, as the conditions can introduce unique challenges to exposure and color balance. Adjusting Exposure and Contrast Images taken in snowy conditions might appear too dark due to underexposure, so increase the exposure slightly in post-processing. For very bright scenes, like in harsh sunlight, recover details in the highlights and shadows to balance the image. Color Correction Weather conditions can cast unique color tints on your photographs. For instance, snowy scenes tend to look very blue. Adjust the white balance in your editing software to correct color casts and achieve more natural-looking images. Capturing the Mood Extreme weather conditions can evoke strong emotional responses. Use this to your advantage by focusing on aspects that convey the mood of the scene. For instance, isolated objects in a vast snowy landscape can highlight themes of solitude and silence, while a lone tree bending in the wind can symbolize resilience. Leonardo Gusmão Araújo often utilizes these elements to enhance the narrative of his photos, turning harsh weather conditions into a storytelling tool. His work illustrates how mastering extreme weather photography can lead to compelling, thought-provoking art. Photography in extreme weather conditions offers a rewarding challenge for dedicated photographers. It requires not only technical skill and creativity but also an understanding of nature's forces and a respect for the environment. By adequately preparing, understanding your equipment's limitations, and focusing on safety, photographers can capture stunning images that highlight the dramatic beauty of our world under the most challenging conditions. Whether you're a seasoned professional like Leonardo Gusmão Araújo or a keen amateur, the results can be extraordinarily rewarding, showcasing not just the power of nature, but also the perseverance and ingenuity of the photographer. Published by: Holy Minoza
First established in July 2016, The Network and Information Systems Directive (NIS), encompassed two groups— the operators of essential services; and relevant digital service providers. The aim of the directive was to strengthen cybersecurity resilience and, while somewhat effective, it was seen to have limitations. Not least the narrow scope of organisations covered. This was addressed in January 2023, when the European Union adopted a new version of the Directive. NIS2 expands the scope of entities covered from seven to 18, adding new sectors based on how crucial they are for the economy and society, broken into two categories — essential and important. For essential organisations with a headcount of over 250 or in excess of €50 million revenue; and important organisations with a headcount over 50 or in excess of €10 million revenue from the sectors identified in NIS2 will be directly included in the scope. That doesn't mean small or micro-organisations are excluded. Each member state can extend the scope to include any organisation (in the identified sectors) deemed to fulfil specific criteria that indicate a key role for society, the economy or for particular sectors or types of service. All EU member states, and non members trading in the EU, will need to transpose NIS2 into national legislation by October 17, 2024. Although no longer bound by EU regulation, the UK government has confirmed it will also strengthen its NIS regulations. What you need to know NIS operates on a principle-based approach that each member state will adopt and publish their own set of security measures to be implemented, allowing cybersecurity to become a part of an organisation's business as usual.. This is similar to multiple international, consensus-driven standards, including ISO/IEC and others, that offer pathways for organisations to develop and implement cybersecurity programs. Organisations understand their business better than an outsider, therefore the principle-based approach allows organisations to make informed decisions on how best to tackle cybersecurity challenges. One important change in the updated Directive is reporting significant incidents within 24 hours to the competent authority or CSIRT. This should be followed after 72 hours with a full notification report including the assessment of the incident, severity and impact and indicators of compromise. A final report must be communicated within a month. While detecting incidents is obviously important, the onus for organisations should be on reducing the risks faced and preventing incidents in the first place. Box ticking does not always equate to security While adhering to the locally adopted NIS2 Directive is mandatory, and failure to adhere can result in large fines, organisations should not be lulled into a false sense of security. It does not always equate that by following frameworks or ticking boxes organisations are secure. The reality is that, while adherence with NIS2 principles will strengthen defences, alone it does not equate to being secure and is not a substitute for maintaining strong cyber hygiene. The onus has to be on every organisation to implement secure working practices that protect their infrastructure and the sensitive data and critical systems contained. True cybersecurity requires complete and holistic understanding of the risks that exist within the entire infrastructure. A preventative approach in Industrial cybersecurity is paramount to eliminate many of the core risks associated with the new trends and challenges that are present. When threat actors evaluate a company's attack surface, they're probing for the right combination of vulnerabilities, misconfigurations and identity privileges. To mitigate the risks, it is essential to gain full visibility into both IT and OT environments — of IT and OT assets, IoT, Building Management Systems, and everything in between, the interdependencies that exist for critical functionality, and determine where weaknesses and vulnerabilities exist. Knowing what is there is only part of the equation as it's imperative to understand how OT devices are interconnected and what interdependencies exist for critical functionality. With that intelligence, security teams then need to identify where weaknesses and vulnerabilities exist and prioritise those assets that could become possible attack paths. From this stance, steps can be taken to remediate the risks where possible, or monitor the assets related to the risk for deviations that could be indicators for attacks. While regulatory compliance can be daunting, it is an important exercise. Knowing the adversary means organisations can anticipate cyber attacks, ensuring they are best positioned to defend against today's emerging threats. As defenders, it's vital that time is taken to understand the data infrastructure and determine where the greatest risks lie, then take steps to reduce that risk. Author: Bernard Montel, EMEA Technical Director and Security Strategist, Tenable
Magnitude 2.3 - 33 miles SE of Okmok Caldera September 13, 2023 01:22:22 AKDT (September 13, 2023 09:22:22 UTC) 53.1645°N 167.482°W Depth 38.3 miles (62 km) This event has been reviewed by a seismologist - 44 miles (71 km) E of Mt. Recheshnoi - 50 miles (81 km) E of Mt. Vsevidof - 55 miles (89 km) SW of Makushin Volcano - 58 miles (94 km) SE of Bogoslof Island - 60 miles (97 km) E of Nikolski - 62 miles (100 km) SW of Unalaska - 64 miles (103 km) SW of Dutch - 83 miles (134 km) SW of Akutan Pass - 93 miles (150 km) E of Kagamil Island - 95 miles (154 km) E of Uliaga Island - 97 miles (157 km) SW of Akutan - Magnitude type: Ml2 - Event type: earthquake Tectonic Setting of the Aleutian Islands The Aleutian Arc marks the region where the Pacific Plate subducts into the mantle beneath the North American Plate. It is a seismically active region, evidenced by the thousands of earthquakes occurring each year. Since 1900, this region has hosted several major megathrust earthquakes, including the 1957 M8.6 in the Andreanof Islands, the 1965 M8.7 in the Rat Islands, the 1986 M7.9 and the 1996 M7.9 in the Andreanof Islands, and the 2003 M7.8 in the Rat Islands. Together they have ruptured the entire length of the megathrust boundary in this region. Another notable source of seismicity in the arc is the zone 6-9 miles (10-15 km) wide of intermediate-depth earthquakes within the subducting Pacific Plate, known as the Wadati-Benioff Zone. The largest recorded intermediate-depth earthquake in this region was the 2014 M7.9 Little Sitkin event. A third source of seismicity in this region are shallow earthquakes associated with volcanic processes and crustal faults within the overriding North American Plate. They occur regularly and may produce vigorous aftershock or swarm-like sequences.
Guest blogger Matthew Coniam writes: In his essay The Decline and Fall of the Movie, Leslie Halliwell uses the following quote from Jonathan Swift to encapsulate his attitude to the cinema, and in particular to explain how his love of Hollywood's golden age could sit happily alongside an almost total disinterest in and disdain for its present: "I hate and detest that animal called man, although I heartily love John, Peter, Thomas, and so forth." It's an opinion I more or less share. I too have my Peters and Johns – off the top of my head: Jaws, The Fog, Ghost World and The Straight Story would top the list – but the overwhelming majority of post-'60s cinema leaves me cold. In particular, I have a loathing for the supposedly great works of '70s Hollywood – One Flew Over the Cuckoo's Nest, The Godfather, Apocalypse Now, The Deer Hunter, that one in space with the laser swords and the little robots, forget the name of it for a minute – that verges on the certifiable. Even films I saw 10 years ago and liked rarely hold up for me once a little water has flowed between us. Titanic, for instance, I initially had pegged as a glorious, old-style tear-jerker: the petty resentments of stuck-up critics who mocked the script and performances, I confidently predicted, would come to look as transparent and silly as those few who tried to write off Gone With the Wind. I was amazed to watch it again recently and see that they were right: it's a terrible film. Even the effects no longer impress overmuch: what we took to be realistic was in fact merely state of the art, and the trickery already looks almost as distancing, and fully as much a product of its time, as that of a '50s sci-fi movie. Now, by and large, nobody gets uppity when I say that I hate the taste (and indeed the thought) of mushrooms. But for some reason I've often noticed people getting strangely resentful when I say that I don't watch new movies, listen to modern music or watch any television at all, as if I was expressing a judgement about their taste rather than mine. Some of the more popular responses: I'm being pretentious. I'm cutting off my nose to spite my face. It's a shame I'm so unyielding, because I don't know what I'm missing. But what, on the face of it is so strange, or inconsistent, or hard to accept, about liking old movies and disliking new ones? And what is elitist about having, and expressing, a preference? That's the conundrum I intend getting to the bottom of here. Firstly, though it baffles me personally, there is of course no a priori reason why a person cannot like both classic and modern cinema. The thing that strikes me as odd is the almost automatic supposition that if one likes the former, one would, or should, like both. It's a supposition that rarely works the other way round, I've noticed. I wouldn't expect anyone who rushed out to see Transformers: Revenge of the Fallen ("screenplay by Ehren Kruger, based on Hasbro's Transformers action figures": now there's a credit to fill you with hope for the future of the medium) to enthuse about Monroe Owsley, have strong opinions about whether Charley Chase is better in silents or talkies, or feverishly collect Irene Ware films. Yet when I, to whom all of the above applies, say that I'd rather spend a week underground with a mobile phone salesman than another minute looking at Will Ferrell's face… suddenly I'm the one with the big attitude. I have known people laugh when I say I regularly watch black-and-white films, as if I'd said I liked reading Beowulf by candlelight in a Hebridean cave. Black and white! The idea! I've met people who thought I was joking when I said I liked silent films. (Often old people, dismayingly enough.) Well, choosing to spend 90 minutes in the company of Tom Cruise, or Lars von Trier or Ken Loach or Wes Anderson, strikes me as pretty wacko, too. But the much more important point is this: Of course there are some modern films that I have enjoyed, especially from non-English-speaking Europe, where – for the moment at least – both depth and style remain fashionable, but even these do not strike me as examples of the same thing as the classic movies with which I am obsessed. I mean, what do they really have in common? Just this (and, increasingly, not even this): they are both forms of visual representation created by passing a beam of light through a strip of celluloid on which photographic impressions of human activity have been recorded. That's it, ladies and gentlemen. That's the common factor. That's the obvious and vital link that makes Mr Deeds Goes to Town an example of the same thing as Being John Malkovich, and makes me a crank or curmudgeon for loving the one like a firstborn child and hating the other with the kind of passion I ordinarily reserve for religious fanatics and salad. How dare I? Yet as I understand it, if you love old Hollywood–not just the list of approved masterpieces but the whole world and scent and flavour of old Hollywood, then you are in love with something that simply does not exist anymore, regardless of how good the occasional half-watchable film may still be on its own terms. Classic Hollywood cinema is – and I mean this not as a judgement but as a simple statement of fact – a unique phenomenon, product of a unique set of circumstances and individuals, operating in a unique way at a unique point in time. The studio system, long gone, produced a body of work that is to cinema generally what an illuminated medieval manuscript is to books generally. Shot almost entirely in studios, by contract artists, operating under an imposed censorship system, so that each studio had its own instantly recognisable atmosphere, regular stable of players, and totally artificial style. This is what I love. When that changed, as first the studio system and then the Hays Code collapsed, a clear before-and-after line can be drawn in the product. The stars migrate from studio to studio, individual studio styles disappear, real locations, widescreens and other forms of pseudo-realism replace the artistic creations of the old studio photographers and set designers with drab singularity, and uniformity of manner and message gives way to a thousand discordant voices all vying to see who can shout loudest for your dollar. These things, that make the earlier films so fundamentally different from what followed, are the specific things that attract me to them. I have no passion for modern cinema. Even among the films I admired, hardly any have added something to my life, or given me any strong desire to see them again. Whereas if you told me I had just watched The Old Dark House for the last time I'd cry and fall over. Films are an interest, old Hollywood is a passion. Now, this all seems so straightforward to me that I wonder if the problem isn't somewhere in the very terminology we use. 'Classic' is a slippery term. On the one hand it can be used as a judgement – to be deemed a classic is a marker of quality – on the other it is used as a description, to mean films of a certain age. (Leonard Maltin's Classic Movie Guide covers all films pre-1960.) For most people I think it means a combination of the two – a retrospective bestowing of approval on a film that has been around long enough to have stood the test of time, hence the tentative use of phrases like 'modern classic' or 'future classic' to refer to Fargo or American Beauty or Christ knows what other ordure happens to be flavour of the month this month. I'd like to see these two meanings divorced, so that we can talk about classical and modern cinema just as we talk of classical and modern music. Yes, everyone knows classical music is better than modern music, especially those who claim otherwise, but that's not what the term means. It refers to a style only, and any related associations of higher quality spring incidentally from the terms of the drawn distinction itself. So how about continuing to use 'classic' as a qualitative term to recognise individual quality, but 'classical' as a quantitative term to define that whole world, and way of doing things, that existed between the creation of American cinema and the collapse of the original structures and strictures, somewhere in the fifties. One final point. I do realise I have spoken only about old and new mainstream Hollywood. Many have written that yes, American pop cinema is a parched field of rotting weeds, but salvation is at hand in the great third way: avant-garde, art and independent cinema. Personally, I find even less here to attract me than in the average Hollywood blockbuster. If classical Hollywood is Mozart – or at least Puccini – and modern Hollywood is Justin Timberlake, then this lot is Stockhausen. (I even saw Peter Greenaway's name come up – a sobering reminder that there are indeed corners of the world where this pompous buffoon retains the respect long withdrawn by those of us who have to share a country with him.) I really don't mind whether I see Marley and Me again or not, but if you wanted me to sit through Broken Flowers a second time you'd have to nail me down. More genuine creativity, inspiration, effort and love of cinema went into Police Academy 6 than Being John Malkovich. For more of Matthew's views on film, visit Movietone News.
You may be thinking that financing home development is a complicated and daunting task. But fear not! This article will unveil eight financing avenues that are accessible, straightforward, and tailored to your needs. From traditional mortgages to crowdfunding platforms, we will guide you through each option, providing comprehensive knowledge and analysis. With our help, you'll discover the perfect avenue to fund your dream home development project. So let's dive in and explore the possibilities! Key Takeaways - Traditional mortgages and government-backed loans offer stable options with fixed interest rates and lower down payment requirements compared to other forms of financing. - Home equity loans allow borrowers to borrow against the equity built in their homes, typically have lower interest rates, and can provide a substantial amount of money for home renovations or additions. - Construction loans have higher interest rates compared to traditional mortgages, but comparing offers and shopping around can help find competitive rates. - Personal loans and peer-to-peer lending are flexible and accessible financing options that provide quick access to funds for home development projects. Traditional Mortgages If you're looking for a reliable way to finance your home development project, consider exploring the option of a traditional mortgage. A traditional mortgage is a loan provided by a bank or a lending institution to help individuals purchase or refinance a home. This type of financing is widely used and offers numerous benefits. One of the main advantages of a traditional mortgage is the stability it provides. With a fixed interest rate and predictable monthly payments, you can accurately budget and plan for the future. Additionally, traditional mortgages often offer longer repayment terms, allowing borrowers to spread out their payments over a longer period of time. This can be particularly helpful when undertaking a large-scale home development project. Furthermore, traditional mortgages typically have lower interest rates compared to other forms of financing, making them a cost-effective option. As you consider your options, it's important to note that government-backed loans, such as FHA loans or VA loans, are also available. These loans are insured by government agencies and offer additional benefits, which we'll discuss in the next section. Government-backed Loans You can explore government-backed loans as a viable financing option for your home development project. These loans are backed by government agencies such as the Federal Housing Administration (FHA) or the Department of Veterans Affairs (VA), providing lenders with a guarantee in case of default. Here are three key benefits of government-backed loans: - Lower down payment requirements: Government-backed loans often have lower down payment requirements compared to traditional mortgages. For example, FHA loans typically require a down payment as low as 3.5% of the purchase price, making homeownership more accessible for individuals with limited savings. - Flexible credit requirements: These loans are designed to help borrowers with less-than-perfect credit histories. Government-backed loans may have more lenient credit score requirements and consider alternative credit histories, such as rental payment history or utility bill payments. - Streamlined refinancing options: If you already have a government-backed loan, you may be eligible for streamlined refinancing options. These programs allow borrowers to refinance their existing loan with minimal documentation and paperwork, potentially lowering their interest rate or monthly mortgage payment. Government-backed loans can be a valuable resource for financing your home development project. It's important to research and compare the specific loan programs available to determine which one best suits your needs and financial situation. Home Equity Loans After exploring government-backed loans, it's important to consider home equity loans as another viable financing option for your home development project. Home equity loans allow you to borrow against the equity you have built in your home. Equity is the difference between the current market value of your home and the outstanding balance on your mortgage. This type of loan can provide you with a substantial amount of money that you can use for various purposes, including home renovations or additions. One of the advantages of a home equity loan is that the interest rates are typically lower compared to other types of loans, such as personal loans or credit cards. This is because the loan is secured by your property, which reduces the risk for the lender. Additionally, the interest you pay on a home equity loan may be tax-deductible, which can provide you with a significant financial benefit. When considering a home equity loan, it's important to carefully evaluate your financial situation and determine how much you can afford to borrow. You should also consider the potential risks associated with this type of loan, such as the possibility of foreclosure if you're unable to make the required payments. Construction Loans When considering construction loans, there are three important points to keep in mind. First, eligibility criteria for these loans can vary, so it's crucial to understand what lenders are looking for. Second, comparing interest rates can help you find the most favorable terms for your project. Finally, the flexibility of repayment terms is an important factor to consider, as it can impact your financial planning and budgeting. Loan Eligibility Criteria To qualify for construction loans, potential borrowers must meet specific eligibility criteria. Here are the key factors that lenders typically consider when evaluating loan applications: - Creditworthiness: Lenders will review your credit score and credit history to assess your ability to repay the loan. - Income and Debt-to-Income Ratio: Lenders will look at your income sources and calculate your debt-to-income ratio to determine if you can afford the loan payments. - Down Payment: Most lenders require a down payment of at least 20% of the project's total cost. - Construction Experience: Demonstrating experience in construction or working with a qualified builder can increase your chances of loan approval. Meeting these eligibility criteria is crucial to secure a construction loan. Once you qualify, you can compare interest rates to find the most favorable financing option for your home development project. Interest Rates Comparison Compare the interest rates on construction loans to find the most cost-effective financing option for your home development project. Interest rates play a crucial role in determining the overall cost of your loan. When comparing interest rates, it's important to consider both the initial rate and any potential rate adjustments over the life of the loan. Construction loans typically have higher interest rates compared to traditional mortgages due to the higher risk associated with the construction process. However, it's still possible to find competitive rates by shopping around and comparing offers from different lenders. Consider factors such as the loan term, repayment schedule, and any additional fees or charges. By carefully evaluating and comparing the interest rates offered by different lenders, you can make an informed decision and secure the most favorable financing option for your home development project. Repayment Terms Flexibility Consider the lender's flexibility in repayment terms when obtaining a construction loan for your home development project. The repayment terms of a construction loan can greatly impact your ability to manage the financial aspect of your project. Here are some key points to consider: - Length of the loan: Look for lenders who offer flexible repayment options, allowing you to choose a loan term that aligns with your project timeline. This will help ensure you have enough time to complete the construction and sell the property. - Interest-only period: Some lenders offer an interest-only period during the construction phase, where you only have to make interest payments. This can provide temporary relief and allow you to focus on completing the project. - Amortization period: Find out if the lender offers flexible amortization periods after the construction is complete. This will determine the length of time you have to repay the principal amount and can impact your monthly payment amount. Personal Loans Explore personal loans as a viable option for financing your home development project. Personal loans are a popular choice for many individuals looking to fund their home development projects due to their flexibility and accessibility. These loans are typically offered by banks, credit unions, and online lenders, providing borrowers with the funds they need to undertake their projects. One of the main advantages of personal loans is the ease of application and approval process. Unlike traditional mortgage loans, personal loans often have a simpler application process, requiring less documentation and time. This allows borrowers to quickly access the funds they need to start their home development project without facing the delays commonly associated with other financing options. Additionally, personal loans offer borrowers the flexibility to use the funds for various aspects of their home development project. Whether you need funds for purchasing materials, hiring contractors, or covering other expenses, personal loans give you the freedom to allocate the money as needed. As we transition into the next section on peer-to-peer lending, it's important to note that personal loans may not be suitable for everyone. It's essential to carefully consider the terms, interest rates, and repayment plans before committing to a personal loan. Peer-to-peer lending, which we'll discuss next, offers an alternative financing avenue worth exploring. Peer-to-Peer Lending Now, let's delve into the world of peer-to-peer lending for your home development project. Peer-to-peer lending, also known as P2P lending, is a form of financing that connects borrowers directly with individual lenders through online platforms. This alternative financing option offers several advantages for your home development needs: - Competitive interest rates: P2P lending platforms often provide lower interest rates compared to traditional financial institutions, making it an attractive option for borrowers. - Flexible loan terms: You have the flexibility to choose the loan amount and repayment period that best suits your needs and financial capabilities. - Quick and convenient process: Applying for a P2P loan is typically quick and hassle-free, with minimal paperwork and a streamlined online application process. Transition: While peer-to-peer lending can be a great option for financing your home development project, it's also worth exploring other avenues such as home development grants. These grants can provide additional financial assistance and support to help you turn your home development dreams into reality. So, let's now move on to discussing the next financing option: home development grants. Home Development Grants Moving forward from peer-to-peer lending, you can now explore the option of home development grants to further support your project. Home development grants are a form of financial assistance provided by various organizations, both government and private, to individuals or entities involved in home development projects. These grants aim to promote affordable housing, community development, and urban renewal. Home development grants come with several advantages. First and foremost, they provide financial support that doesn't need to be repaid. This can significantly reduce the burden of financing your home development project. Additionally, grants often come with fewer restrictions compared to loans, allowing you more flexibility in how you allocate the funds. To access home development grants, you need to research and identify the organizations or programs that offer such funding. Government agencies, non-profit organizations, and foundations are some common sources of grants for home development projects. It's essential to carefully review the eligibility criteria and application requirements to increase your chances of success. When applying for home development grants, you'll typically need to provide detailed information about your project, including its goals, timeline, and budget. It's crucial to demonstrate how your project aligns with the objectives of the grant program and how it will benefit the community. Crowdfunding Platforms When considering financing options for home development, crowdfunding platforms can offer several benefits. Firstly, crowdfunding allows you to tap into a large pool of potential investors who are interested in supporting projects like yours. Secondly, success stories from crowdfunding campaigns demonstrate the potential for raising significant funds and gaining exposure for your project. Lastly, to increase your chances of success, it's important to follow some tips for crowdfunding, such as setting clear goals, creating an engaging campaign, and leveraging social media to reach a wider audience. Benefits of Crowdfunding One of the most significant benefits of crowdfunding platforms for home development is that they provide you with a wide range of potential investors. This can greatly increase your chances of securing the necessary funds for your project. Here are some reasons why crowdfunding platforms are a beneficial avenue for financing home development: - Access to a large pool of investors: Crowdfunding platforms allow you to tap into a diverse network of investors who are specifically interested in supporting real estate projects. - Lower barriers to entry: Unlike traditional financing options, crowdfunding platforms often have lower minimum investment requirements, making it easier for individuals to participate in your project. - Increased visibility and marketing opportunities: By listing your project on a crowdfunding platform, you can gain exposure to a wider audience, potentially attracting more investors and increasing the success of your fundraising campaign. Success Stories From Crowdfunding If you're considering crowdfunding platforms for financing your home development project, you'll be interested to hear about some success stories. Crowdfunding has become a popular option for individuals looking to raise funds for their projects, and many have found great success through these platforms. One such success story is the case of a couple who used a crowdfunding platform to raise money for their dream home. They created a compelling campaign and were able to exceed their funding goal, allowing them to build their dream home. Another success story involves a group of friends who wanted to develop an eco-friendly housing community. Through a crowdfunding platform, they were able to gather enough funds to purchase land and start their project. These success stories highlight the potential of crowdfunding platforms as a viable financing avenue for home development projects. Tips for Crowdfunding Success To achieve crowdfunding success on platforms, you must strategically plan and execute your campaign. Here are three tips to help you navigate the world of crowdfunding platforms: - Research and choose the right platform: Not all crowdfunding platforms are created equal. Take the time to research and understand the different platforms available to you. Consider factors such as fees, target audience, and success rates. Choose a platform that aligns with your project and has a track record of success in your industry. - Craft a compelling campaign: Your campaign needs to stand out from the crowd and capture the attention of potential backers. Create a compelling story that clearly communicates your project's purpose, benefits, and why people should support it. Use visuals, videos, and testimonials to enhance your campaign's appeal. - Engage your network and beyond: While crowdfunding platforms can help you reach a wider audience, don't rely solely on them. Leverage your existing network and actively engage with potential backers through social media, email marketing, and public relations. The more people you can get excited about your project, the more likely you're to achieve crowdfunding success. Frequently Asked Questions What Are the Eligibility Requirements for Government-Backed Loans? To get government-backed loans, you gotta meet certain criteria. They'll be checkin' your credit score, income, and debt-to-income ratio. Plus, you gotta have a stable job and a down payment ready. How Does the Interest Rate on a Home Equity Loan Compare to Other Financing Options? The interest rate on a home equity loan can vary depending on factors such as your credit score and the current market conditions. It's important to compare rates with other financing options to determine the best choice for your home development project. Can Personal Loans Be Used for Both Land Purchase and Home Construction? Yes, personal loans can be used for both land purchase and home construction. They offer flexibility, with interest rates typically ranging from 6% to 36%. However, eligibility depends on credit score and income. Are There Any Specific Qualifications for Obtaining a Construction Loan? To obtain a construction loan, you'll need to meet certain qualifications. Lenders typically require a good credit score, stable income, and a detailed construction plan. Make sure to have all the necessary documentation ready. What Are the Typical Repayment Terms for Peer-To-Peer Lending in the Context of Home Development? When it comes to peer-to-peer lending for home development, the typical repayment terms vary. However, it's important to consider factors like interest rates, loan duration, and any additional fees before making a decision.
For those following a ketogenic diet, navigating the world of alcoholic beverages can be tricky. While many cocktails and wines can be high in sugars and carbs, beer presents a unique challenge due to its carbohydrate content. However, not all hope is lost for beer enthusiasts on the keto diet. With careful selection, it is possible to enjoy beer while staying within your dietary goals. In this article, we'll explore which beers are keto-friendly and provide tips for making smart choices when indulging in a cold brew. Understanding the Keto Diet Before delving into which beers are keto-friendly, it's essential to understand the principles of the ketogenic diet. This high-fat, low-carb diet aims to put the body into a state of ketosis, where it burns fat for fuel instead of carbohydrates. To achieve and maintain ketosis, followers of the diet typically consume fewer than 50 grams of carbs per day, although individual needs may vary. The Impact of Beer on Ketosis Beer is known for its carbohydrate content, primarily derived from malted barley, wheat, and other grains used in the brewing process. These carbohydrates can quickly add up, making many beers unsuitable for those on a keto diet. Additionally, beer often contains sugars, which can further hinder ketosis. Choosing Keto-Friendly Beers While beer may seem off-limits for keto dieters, there are options available that are lower in carbs and sugars. When selecting a beer, look for those with lower alcohol by volume (ABV) and lighter body, as these tend to have fewer carbohydrates. Light beers, session IPAs, and certain styles like pilsners and kölsch are often lower in carbs compared to stouts, porters, and IPAs. Reading Labels and Nutritional Information One of the most reliable ways to determine if a beer is keto-friendly is by reading the label and nutritional information. Look for beers that explicitly state their carb content per serving. Be wary of terms like "lite" or "low-calorie," as these do not necessarily mean low-carb. Instead, focus on the actual carbohydrate count listed on the label. Common Keto-Friendly Beer Styles Certain beer styles naturally lend themselves to being more keto-friendly due to their lower carbohydrate content. For example, light lagers, such as American lagers and European pilsners, are typically lower in carbs compared to heavier, maltier styles. Similarly, session IPAs, which are lower in alcohol and lighter in body, can be a good option for those watching their carb intake. Avoiding High-Carb Additions Some beers may contain added ingredients that can significantly increase their carbohydrate content. For example, fruit-flavored beers, spiced ales, and beers brewed with added sugars or syrups are likely to be higher in carbs. When in doubt, opt for beers brewed according to traditional methods with minimal additives. Low-Carb Brewing Techniques In recent years, some craft breweries have begun experimenting with low-carb brewing techniques to cater to health-conscious consumers, including those on keto diets. These techniques may involve using alternative grains, such as rice or corn, in place of traditional barley and wheat. Additionally, brewers may employ enzymes to break down complex carbohydrates into simpler sugars that can be fermented into alcohol, resulting in a beer with fewer residual sugars and carbs. Moderation is Key While some beers may be lower in carbs than others, it's essential to remember that alcohol itself contains calories and can interfere with ketosis if consumed in excess. Additionally, alcohol can lower inhibitions and lead to poor food choices, which can sabotage your keto diet goals. As with any dietary indulgence, moderation is key when enjoying beer on a keto diet. Tips for Enjoying Beer on a Keto Diet If you're planning to indulge in beer while following a keto diet, here are some tips to help you make smart choices: Plan Ahead: Before heading out to social gatherings or events where beer will be served, research your options ahead of time. Look for breweries or bars that offer low-carb beer choices. Choose Lighter Options: Opt for lighter beer styles, such as lagers, pilsners, and session IPAs, which are typically lower in carbs than heavier styles like stouts and porters. Read Labels: Always read the label and nutritional information before purchasing or consuming a beer. Look for beers with the lowest carbohydrate content per serving. Watch Portions: Be mindful of portion sizes and stick to one or two servings to avoid consuming excess carbs and calories. Stay Hydrated: Alternate alcoholic beverages with water to stay hydrated and help mitigate the dehydrating effects of alcohol. Pair with Keto-Friendly Foods: If you're enjoying beer as part of a meal, pair it with keto-friendly foods like grilled meats, seafood, and leafy greens. Monitor Ketone Levels: If you're concerned about how beer may impact your ketosis, consider monitoring your ketone levels using urine strips or a blood ketone meter. By following these tips and making informed choices, you can enjoy beer while staying true to your keto diet goals. While beer may not be the most keto-friendly beverage choice, it is still possible to indulge in moderation while following a ketogenic diet. By selecting beers with lower carbohydrate content, reading labels carefully, and practicing moderation, you can enjoy a cold brew without derailing your dietary goals. Remember to prioritize your health and listen to your body's cues when enjoying beer on a keto diet. With the right approach, you can savor the flavors of your favorite beers while staying on track with your keto lifestyle.
The federal agency announced it is monitoring video games that include in-app purchases, digital currency, and external marketplaces commonly used by children. According to , games that include these features effectively function as a type of bank, but are not subject to the same types of regulation or protection. Consumer Financial Protection Bureau Report It was released last week. The agency also questioned whether children and parents were aware of the vast amount of data gaming companies collect. "In recent years, the most popular video games have included immersive virtual worlds that provide storage and exchange of valuable assets," the CFPB wrote. "Game companies have created digital marketplaces that facilitate the buying, selling, and trading of these assets with limited consumer protection. Harmful practices are occurring." Video games like the blockbuster Fortnite have long allowed users to make microtransactions, small optional fees that players can pay to obtain items or other features. Users often have to purchase in-game currency with real dollars, similar to tokens purchased at brick-and-mortar stores such as Dave & Buster's or Chuck E. Cheese. Goats, Google, and games: Future implications of tech giant's efforts to train AI to play video games The CFPB warned that digital currencies, purchased goods and other assets can reach "substantial value" when converted into real money. However, regulations aimed at protecting asset owners are not applied to these closed markets. "Banking and payment services that facilitate the storage and exchange of valuable assets generally provide consumer protections, including remedies after fraudulent transactions," the CFPB said in its report. "However, game and virtual world operators typically emphasize a 'buyer beware' approach." The agency was particularly concerned about children who may take advantage of these markets without their parents' knowledge. "For many young people today, gaming may serve as an introduction to financial activities," the CFPB writes. "For example, games offer young people the opportunity to learn about earning currency, managing assets and shopping." Now that artificial intelligence can clone voices, video game actors must consider their options "Game companies may view young players as an opportunity to create lifelong consumers early," the report continued. Since players can accumulate assets worth considerable real money in these video games, gamers can face significant financial losses if their accounts are hacked or fall prey to scammers . According to the CFPB, these risks are increasing as the value of gaming assets increases. However, players may have limited recourse as traditional banking and payment system protections do not apply. "In a complaint to the government, [Federal Trade Commission] The CFPB and CFPB said several players reported hacking attempts, account theft, fraud, unauthorized transactions, and loss of access to game currency and virtual items, but there were limited remedies from gaming companies, the agency said. is writing. Players can avoid these scams and phishing attempts. " Meanwhile, the CFPB report says publishers can also collect important information about users, including location data, social media data, and behavioral interactions "such as how players respond to personalized incentives." "Gamers are at risk of harm when their data is sold, bought, or traded between companies, including for purposes other than gameplay," the report continued. "Furthermore, the vast accumulation of data that gaming companies collect from consumers means that consumers, especially young people and their parents, are wondering how their data is being collected and whether privacy regulations are being followed. It raises the question of whether we are fully aware of how it is being used in the industry." In the end, the CFPB did not indicate it was taking action against the video game industry, instead saying it was "monitoring" the situation. Ethan Burton is the editor of Digital Originals. You can reach him at firstname.lastname@example.com and follow him on Twitter @ethanrbarton.
Trading Strategies: Several trading strategies can be employed to increase the chances of successful binary options trading. One popular strategy is the trend-following approach, where traders analyze historical price data to identify patterns and trends. By identifying an upward or downward trend, traders can make informed decisions regarding their chosen option. Binary options trading has gained significant popularity in recent years due to its simplicity and potential for substantial financial gains. With the advent of copy trading, a revolutionary concept that allows novice traders to mimic the strategies of experienced professionals, the opportunities for success in binary options have expanded further. This article aims to explore the concept of copy trading and how it can be utilized to trade binary options and generate significant profits in a single day. Copy Trading in Binary Options: Copy trading has gained popularity due to its ability to replicate the trades of successful traders. This strategy allows novice traders to benefit from expert knowledge and experience without the need for extensive market analysis. By directly copying the trades of successful traders, investors can potentially increase their chances of winning and generating profits. Understanding Binary Options: Binary options represent a financial derivative that offers a fixed payout upon the fulfillment of a specific condition within a predetermined timeframe. Traders speculate on the price movement of various assets, such as stocks, commodities, currencies, or indices, predicting whether the price will rise or fall within a given time period. As such, binary options offer a straightforward and accessible means of engaging in financial markets. 2. Risk Management: While copy trading minimizes the need for in-depth market analysis, it is still essential to understand and manage risk. Set appropriate stop-loss orders and manage your overall trading capital wisely to protect against potential losses. Copy Trading: Copy trading, also known as social trading, is a practice in which traders replicate the trades of successful investors. It leverages the expertise and strategies of seasoned traders, enabling beginners to profit from their knowledge. Unlike traditional investment methods, binary options copy trading eliminates the need for binary options extensive market research and analysis, making it a popular choice among individuals seeking quick profits. 2. Time-Saving: Active trading requires significant time commitment and constant monitoring of market conditions. Through day copy trading, individuals can passively engage in trading while experienced traders execute trades on their behalf. This approach eliminates the need for continuous monitoring and allows investors to focus on other commitments. Benefits of Binary Options Trading: 1. High profitability: Binary options trading offers lucrative returns, with profit percentages ranging from 60% to 90% on successful trades. 2. Simplicity: The trading process is relatively straightforward, suitable for both experienced and novice traders. 3. Quick results: Binary options have short expiry times, allowing traders to see immediate results and make rapid investment decisions. 4. Diverse asset range: Traders can choose from a wide range of assets, including stocks, commodities, binary options currencies, and indices, offering ample trading opportunities. 4. Learning Opportunity: Copy trading provides an excellent learning opportunity for novice traders. By observing the actions and strategies of experienced traders, individuals can gain insights into market trends, risk management techniques, and decision-making processes. In conclusion, binary options trading can be a profitable venture for those who approach it with knowledge and caution. Traders should continuously educate themselves, adapt their strategies to changing market conditions, and remain disciplined in risk management practices. Understanding Binary Options: Binary options are a financial derivative where traders speculate on the price movement of an underlying asset within a predetermined timeframe. Traders predict whether the price will rise or fall, and if their prediction is accurate, they receive a fixed payout. The simplicity and accessibility of binary options make them an attractive trading instrument for both experienced and novice traders. Furthermore, traders should diversify their portfolio by investing in various assets from different sectors. This reduces the risk of a significant loss in case of adverse market conditions affecting a specific asset or sector. 3. Monitor Market Conditions: Stay updated on market news and events that may impact the assets being traded. This information can help anticipate potential price movements and adjust your copy trading strategy accordingly. 4. Accessibility: Binary options copy trading platforms are easily accessible and provide a user-friendly interface for traders of all levels. These platforms often offer comprehensive statistics, performance indicators, and user rankings, enabling traders to make informed decisions when selecting the traders they wish to copy.
Breadcrumb Home > Thesaurus > Q Synonyms of queerness Find synonyms for: Noun 1. oddity, queerness, quirk, quirkiness, crotchet, unfamiliarity, strangeness usage: a strange attitude or habit 2. homosexuality, homosexualism, homoeroticism, queerness, gayness, sexual activity, sexual practice, sex, sex activity usage: a sexual attraction to (or sexual relations with) persons of the same sex WordNet 3.0 Copyright © 2006 by Princeton University. All rights reserved. TrendingHere are the facts and trivia that people are buzzing about. Chinese New Year History, Meaning, and Celebrations Current Events This Week: February 2024 Valentine's Day Valentine's Day History Mardi Gras 30 "Charlie and the Chocolate Factory" Quotes ✖ Related Content Daily Word Quiz: porcine Analogy of the Day: Today's Analogy Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language
How far is Mombasa from Shinyanga? The distance between Shinyanga (Shinyanga Airport) and Mombasa (Moi International Airport) is 427 miles / 687 kilometers / 371 nautical miles. The driving distance from Shinyanga (SHY) to Mombasa (MBA) is 598 miles / 963 kilometers, and travel time by car is about 14 hours 24 minutes. Shinyanga Airport – Moi International Airport Search flights Distance from Shinyanga to Mombasa There are several ways to calculate the distance from Shinyanga to Mombasa. Here are two standard methods: Vincenty's formula (applied above)- 427.070 miles - 687.302 kilometers - 371.114 nautical miles Vincenty's formula calculates the distance between latitude/longitude points on the earth's surface using an ellipsoidal model of the planet. Haversine formula- 426.596 miles - 686.540 kilometers - 370.702 nautical miles The haversine formula calculates the distance between latitude/longitude points assuming a spherical earth (great-circle distance – the shortest distance between two points). How long does it take to fly from Shinyanga to Mombasa? The estimated flight time from Shinyanga Airport to Moi International Airport is 1 hour and 18 minutes. What is the time difference between Shinyanga and Mombasa? Flight carbon footprint between Shinyanga Airport (SHY) and Moi International Airport (MBA) On average, flying from Shinyanga to Mombasa generates about 88 kg of CO2 per passenger, and 88 kilograms equals 194 pounds (lbs). The figures are estimates and include only the CO2 generated by burning jet fuel. Map of flight path and driving directions from Shinyanga to Mombasa See the map of the shortest flight path between Shinyanga Airport (SHY) and Moi International Airport (MBA). Airport information Origin \| Shinyanga Airport \| City: \| Shinyanga \| Country: \| Tanzania \| IATA Code: \| SHY \| ICAO Code: \| HTSY \| Coordinates: \| 3°40′1″S, 33°25′1″E \| Destination \| Moi International Airport \| City: \| Mombasa \| Country: \| Kenya \| IATA Code: \| MBA \| ICAO Code: \| HKMO \| Coordinates: \| 4°2′5″S, 39°35′39″E \|
Identities and Meaning Structures Journal Title Journal ISSN Volume Title Repository Usage Stats Sociologists have for long explored how identities, the labels or categories people employ to define themselves and others, affect a number of processes. In this dissertation, I conduct three studies that deal with different aspects of identity and identity-related processes. Chapter 2 deals with stigmatization and identity restoration after a wrongdoing. I investigate whether prosociality (i.e., helping others at a cost to oneself) can mitigate negative perceptions of a moral transgressor. I utilize affect control theory and its impression formation principles to derive hypotheses about how perceptions of the moral transgressor will change according to levels of future prosociality and perceptions of the goodness-badness and powerfulness-powerlessness of prosociality beneficiaries. I show prosociality positively can restore positive perceptions of the protagonist, depending on who benefits from prosociality. Benefitting people perceived as good has more of a restorative effect compared to benefitting people perceived as weak. Results suggest prosocial behaviors lead to positive perceptions to the extent that they benefit those seen as deserving the benefit. Chapter 3 addresses the problem of identity structures by explicitly conceptualizing them as multilayer networks of interrelated identities. Using network analysis techniques, I map identity structures and investigate which (if any) elements lie at the center of the structure. In addition, investigate the claim that values, abstract ideals that guide action, connect identities from different domains. I show country citizenship emerges as the most central node in the between-nations network. Other nodes act as intermediate hubs, connecting domain-specific regions (e.g., family or occupation) with the rest of the network. Values reliably occupy a peripheral position in the observed networks. Chapter 4 investigates political belief systems and their organization in European countries. I employ Belief Network Analysis (BNA), a recently developed method in the sociology of culture (Boutyline and Vaisey 2017), to identify central elements in political belief systems across Europe. In its first application, BNA showed political ideology lies at the center of a network of political beliefs in the United States. I examine whether a similar pattern is observed in European political belief systems. Contrary to the U.S. case, I do not find political ideology lies at the center of the observed structures. I discuss possible factors driving this finding as well as a number of future directions that could shed light on these contradictory results. This dissertation aims to improve our understanding of identity structures and processes. The study in Chapter 2 informs how identity processes influence moral judgments and stigmatization. The study in Chapter 3 is an initial step of a research program that leverages the strengths of the networks approach to understand identity structures. The study of political beliefs in Chapter 4 sheds light on identity meanings attached (or not) to the ideological identity across cultural contexts. Flor, Ramos Cristina (2020). Identities and Meaning Structures. Dissertation, Duke University. Retrieved from https://hdl.handle.net/10161/20963. Dukes student scholarship is made available to the public using a Creative Commons Attribution / Non-commercial / No derivative (CC-BY-NC-ND) license.
RDP 2000-03: Some Structural Causes of Japan's Banking Problems 1. Introduction May 2000 - Download the Paper 297KB At the start of the 1990s, Japanese banks were held in reasonably high regard. There was a consensus in industrial organisation theory that they selected and monitored their industrial clients efficiently and that they met the need for corporate governance in a way that the takeover market could not. For this reason, it was widely believed that financial intermediation was one source of the productivity growth that had fuelled Japan's postwar economic expansion (Calder 1993). By the end of the decade, those impressions had dissipated. Growth had stagnated, and in ways that reflect badly on the banks. By disrupting financial intermediation, the non-performing loans of Japanese banks have constrained investment for the better part of a decade. In 1998, they were equal to roughly 25 per cent of GDP (Lincoln 1998), and at the end of March 1999, they still constituted 12 per cent of outstanding credit exposure (OECD 1999, p 87). Some of the longer-term causes of those problems lie in the deterioration of banks' loan portfolios which occurred during the 1980s. Over this period, banks developed large exposures to borrowers who were either very vulnerable to falling asset prices or were, for other reasons, not very creditworthy. Not only did banks accept substantial credit risk by targeting these borrowers, they apparently attenuated their monitoring and screening of them. This paper surveys some of the literature which explains the deterioration in the quality of the banks' loan portfolios. It focuses on two hypotheses that have emerged in the corporate finance literature. The first is that capital market reform over the 1980s encouraged high-quality borrowers to secure disintermediated forms of finance, with the result that an adverse selection problem developed in the Japanese bank lending market. The second is that the simultaneous deregulation of the wholesale funds and retail lending markets compressed the margins of banks. Given the various safety nets in operation in Japan at the time, it was rational of the banks to respond to the reduction in their franchise values by targeting borrowers which presented greater risks but offered higher nominal rates of return. Much of the accumulated exposure of banks to firms which were vulnerable to the asset price collapse of the early 1990s can be understood in terms of these two ideas. Macroeconomic developments inform both arguments. During the 1970s, economic growth began to slow. This required financial reform, which in turn, eventually caused some dislocation of the domestic banking system. The problems worsened in the late 1980s, as monetary policy was eased in response to falling consumer price inflation and an appreciating nominal exchange rate. This substantially eroded the franchise values of banking. The next section presents a stylised overview of Japan's corporate finance markets prior to the 1980s. Section 3 profiles the subsequent deregulation of the system, and it reviews some of the theories which relate the changes in the corporate finance market to the changes in bank behaviour. The final section summarises the analysis.
Checklist of things to do before your students head off to College There are a few things parents and their children need to make sure they do before heading off to college. Here is a list courtesy of Parent Toolkit: Fill out any required forms and documents. There are always forms that slip through the cracks. Your student will need to make sure their college gets a final high school transcript and proof of graduation. Be on the lookout for last minute documents, like housing forms and financial aid/scholarship forms that need to be submitted. Make sure your student's health is covered. Double-check your health insurance policy, and talk to your teen about it. Many colleges have student health plans. Fill out any immunization forms required before your student leaves home. For more, check out Transferring Healthcare Responsibility to Young Adults. Make or remind your student of any outstanding payments. Each school will function differently, but you may have housing or tuition payments to make to the school during the summer. Encourage your teen to apply for last-minute scholarships. The summer before and during senior year of high school is a big time for scholarship applications, but the summer after graduation is a time that often goes unutilized. Encourage your teen to apply for scholarships that may help ease the financial burden of college and other miscellaneous expenses. Have a conversation (or several…) about money. Make it clear what you will pay for, and what you will not. Get on track for packing early. It is your teen's responsibility to pack and get ready for college, but you'll likely lend a hand. Starting early always helps, especially when last-minute necessities come up. Coordinate your teen's drop-off to their college. Your teen may be attending college nearby or across the country. Either way, plan how you will get your teen to school, who will be going along on the trip, and how you are going to transport all of your teen's stuff. Encourage your teen to reach out to their roommate(s). If your teen is going to be living in campus housing, like dorms, it may be a good idea for them to get in touch with their new roommate. With Facebook and other social networking websites, it's easy for students to connect a bit before the move-in date. This can help the transition go more smoothly for all involved. Plan for orientation. Orientation happens all throughout the summer at most schools. Plan early for when your student (and you) will be attending. Most schools have a separate orientation for parents at the same time as your student's. Make sure your kid has these key life skills. Doing laundry, cooking, managing a budget…if you haven't had these conversations already, now's the time. Start thinking about parents' weekend. Many schools have a parent weekend where parents can visit campus and their student. If you plan on attending, check this date early, as hotels near campus can fill up quickly.
To improve care for extremely premature infants, the development of an extrauterine environment for newborn development is being researched, known as Artificial Placenta and Artificial Womb (APAW) technology. APAW facilitates extended development in a liquid-filled incubator with oxygen and nutrient supply through an oxygenator connected to the umbilical vessels. This setup is intended to provide the optimal environment for further development, allowing further lung maturation by delaying gas exposure to oxygen. This innovative treatment necessitates interventions in obstetric procedures to transfer an infant from the native to an artificial womb, while preventing fetal-to-neonatal transition. In this narrative review we analyze relevant fetal physiology literature, provide an overview of insights from APAW studies, and identify considerations for the obstetric procedure from the native uterus to an APAW system. Lastly, this review provides suggestions to improve sterility, fetal and maternal well-being, and the prevention of neonatal transition. Original language \| English \| Article number \| 1360111 \| Number of pages \| 17 \| Journal \| Frontiers in Pediatrics \| Volume \| 12 \| DOIs \| \| Publication status \| Published - 15 Feb 2024 \| - extra-uterine life support - perinatal life support - artificial womb - artificial placenta - fetal physiology - neonatal transition - transfer procedure Dive into the research topics of 'Transferring an extremely premature infant to an extra-uterine life support system: a prospective view on the obstetric procedure'. Together they form a unique fingerprint.Research areas Perinatal Medicine M.B. (Beatrijs) van der Hout-van der Jagt (Content manager) & Eugenie Delvaux (Content manager) Impact: Research Topic/Theme (at group level)
Raitio, Kaisa - Department of Urban and Rural Development, Swedish University of Agricultural Sciences Research article2020Peer reviewedOpen access Osterlin, Carl; Raitio, Kaisa Human induced land-use change through natural resource extraction has significant ecological, social and cultural effects for indigenous communities. Indigenous rights, cultural practices and identities are strongly interconnected with traditional lands. In northern Sweden, the cumulative effects from natural resource extraction have become increasingly problematic for Sami reindeer herding. Land use planning and permit processes are organized based on single projects or policy sectors, instead of the needs and rights involving reindeer herding. Existing research has demonstrated loss of ground and arboreal lichen, fragmentation of pastures and reindeer avoidance of otherwise valuable pastures due to disturbance caused by competing land uses. There is however a lack of synthesis of the amount and scale of encroachments on traditional Sami territories in Sweden so far. Likewise, while research has looked at weaknesses of the sectoral regulations in terms of cumulative impact assessment and the inadequate recognition of Sami reindeer herding rights, no studies have analyzed the meta-pressure caused by the fragmented planning regime as a whole, as the amount of regulations regarding different land use sectors and permitting processes increases with each new type of competing activity. Through the concept ofdouble pressurecaused by the inter-related processes of fragmented landscapes and fragmented 'planscapes', this study seeks to capture the actual pressure the affected communities are currently experiencing. Using multiple quantitative and qualitative data sets consisting of Geographical Information Systems, policy documents, workshops discussions and interviews, we study how natural resource extraction like mining and wind energy has increased on traditional indigenous Sami lands in northern Sweden. By expanding the analytical focus from today's landscapes to both planscapes and the pressure from not-yet realized future projects, our results highlight the need for a holistic understanding of the situation reindeer herding is facing, calling for more relevant and legitimate land use permitting and planning mechanisms to reduce the industrial pressure on the landscape, and to address the social injustices caused by today's planscape. cumulative effects; land use planning; impact assessments; indigenous rights; mining; wind energy; reindeer herding; natural resource extraction 2020, Volume: 9, number: 9, article number: 104 Publisher: MDPI SDG16 Promote peaceful and inclusive societies for sustainable development, provide access to justice for all and build effective, accountable and inclusive institutions at all levels Environmental Sciences related to Agriculture and Land-use DOI: https://doi.org/10.3390/resources9090104
Vehicles and equipment used for underground mining are vital for overall production. The main thing they do is make it easier to get rich minerals and ores from the ground. In this case, the underground mining loader is one of the most important pieces of gear. When it comes to underground mining loaders, two names stand out. One is Fucheng FCYJ – 4D, and the other is Caterpillar R1700G Underground Mining Loader. FCYJ-4D is the preferred choice when comparing these two models. Caterpillar R1700G is known for its sturdy construction and powerful engine. But they are expensive and less efficient than Fucheng FCYJ-4D. This article will focus on the key factors that decide their suitability. Okay, let's begin. Overview of R1700G Underground Mining Loader Caterpillar Inc. is a well-known leader in making large machinery. The R1700G underground mining loader is one of their famous creations. It is a robust and dependable option that works well in harsh underground mining conditions. The R1700G Underground Mining Loader has a lot of different specs and features. It often has a robust Cat C13 engine. This engine can produce high torque and works well even when a high load is on it. The R1700G Underground Mining loader is famous for its robust design and performance. It has a rated capacity of 13 tons. The engine power is 242/263 kW, which produces a rotation speed of 1800 RPM. With this capacity, Cat R1700G ensures efficient material handling in various mining conditions. The Caterpillar R1700G Underground Mining Loader can be used for numerous applications. They are used to load, haul, and dump waste and ore in many situations. They also offer an operator area that is comfortable and easy to use. It usually comes with all the controls you need. Overall, the cabin makes working long shifts underground more comfortable and productive. The Caterpillar R1700G offers reliable options, but it costs more. Other choices, such as the Fucheng FCYJ-4D, have similar features and are more affordable. Also, its smallest bucket size is 4.6 m3, so it might not be ideal for small to medium-sized mining jobs. Overview of Diesel Scooptram FCYJ – 4D The diesel Scooptram FCYJ – 4D is a notable creation of Fucheng. Fucheng is one of the biggest companies that makes LHD vehicles. In Shandong, China, they have their main office. Diesel Scooptram FCYJ – 4D is a notable competitor of Cat R1700G. FCYJ-4D also offers high-quality engines, a safe cabin for the operator, and the latest tech for controlling. These underground scoop trams are also versatile. You can use it in various situations, such as construction, mining, or even compact areas. The rated capacity of FCYJ-4D is 8 tons. It has an engine power of 190 KW, producing rotation speeds up to 2300 RPM. The overall operating weight of this equipment is 25.5 tons. There is a convenient-sized bucket on the FCYJ-4D. It's good at moving things around efficiently. You can use it for small or medium-sized jobs. By comparing its features and specs to those of other LHD vehicles, the FCYJ-4D is a good value. The Fucheng FCYJ-4D has the newest technology, even though it is affordable. It makes operations run more smoothly. The safety cabin also ensures the operator is safe and comfortable during long work hours. Overall, the FCYJ-4D is an excellent alternative for CAT R41700G. Most importantly, you can get all the features and a cost-effective solution in Fucheng vehicles. R1700G Underground Mining Loader vs Diesel Scooptram FCYJ – 4D The Diesel Scooptram FCYJ-4D and the R1700G underground mining loader are prevalent for the same uses. There are features on this equipment that are meant to make it safer, more efficient, and last longer. In general, FCYJ-4D is recommended for use in deep mines. It can handle medium to small underground tunnels because of its compact size and total capacity. Besides, they are also good value for money. Let's look at the following table to learn how they are different. Aspects \| CAT R1700G \| FUCHENG YCYJ – 4D \| Manufacturer \| Caterpillar \| Fucheng LHD \| Bucket Capacity \| 4.6 – 8.8 m³ \| 4 m³ \| Bucket Type \| Various Types Available \| Standard Bucket \| Rated Capacity \| 13 tons \| 8 tons \| Engine Power \| 242/263 KW / 1800 RPM \| 190 KW & 2300 RPM \| Operating Weight \| 42.5 tons \| 25.5 tons \| Transmission Type \| Shift Transmission \| Shift Transmission \| Control System \| Standard Control System \| Advanced Control System \| Suitability \| Ideal for large-scale mining operations \| Suitable for medium to small-scale projects \| Applications \| Underground mining, tunnelling, and heavy-duty hauling \| Underground mining, medium or small-scale excavation, construction \| R1700G Underground Mining Loader vs Diesel Scooptram FCYJ – 4D: Bucket Capacity When looking at bucket sizes, the diesel scooptram FCYJ-4D usually has a 4 m³ capacity. On the other hand, the Cat R1700G underground mine loader can hold up to 8.8m³, which is more. This means the Cat R1700G can be used for medium- to large-scale hauling and loading jobs. But Diesel scoop tram FCYJ-4D works great for small to medium-sized LHD jobs. The difference in bucket sizes between the two models affects efficiency and output. The FCYJ-4D's benefit is that it can be used for smaller-scale activities. It values efficiency and manoeuvrability more than sheer bulk. That is why it is an excellent choice for people who want to do focused extraction. This eventually raises productivity and operational efficiency. R1700G Underground Mining Loader vs. Diesel Scooptram FCYJ – 4D: Design & Structure Two models, R1700G and FCYJ-4D, have a lot in common. First, they both exhibit robust construction. These loaders are made of very strong and high-quality materials. This means that these loaders can handle the rough conditions in deep mines. All the safety features and control tools you need are in the cabin of both loaders. It's easier to use and safer because it's designed to be practical. Also, both CAT R1700G and FCYJ-4D have articulated features. This means that both loaders are designed to be easy to move around. Because of this, they make it easy to move through mines with limited space. R1700G Underground Mining Loader vs Diesel Scooptram FCYJ – 4D: Performance Several things come into play when you talk about their performance. Indeed, each does have its unique pros and cons. First, regarding speed, the FCYJ – 4D generally outperforms the R1700G. This makes FCYJ-4D suitable for operations requiring swift movement. Secondly, the R1700G has more power. Most of the time, it helps when carrying heavy loads. The FCYJ-4D and the R1700G are both very productive and efficient, but they do so in different ways. Regarding mining conditions, FCYJ-4D works well for small to medium-sized mining tunnels. Yes, they are good for these places because they are quick and agile. When it comes to bigger mining sites, the Cat R1700G really impresses. R1700G Underground Mining Loader vs Diesel Scooptram FCYJ – 4D: Efficiency Three things come into play when you compare how efficient they are generally. These are how much fuel it uses, how much it costs to run, and how much care it needs. Firstly, regarding fuel efficiency and operational costs, FCYJ-4D outperforms the R1700G. It consumes less fuel. As a result, it requires lower operational expenses over time. Second, compared to the R1700G, the FCYJ-4D has a simpler design and construction. In a technical sense, this reduces the need for upkeep and downtime. Keep in mind that FCYJ-4D spare parts are easy to find. So, we can say that the diesel scooptram FCYJ-4D is more reliable than the Cat R1700G. R1700G Underground Mining Loader vs Diesel Scooptram FCYJ – 4D: Cost-Effectiveness You can compare the cost-effectiveness of Cat R1700G and FCYJ-4D in two ways. These are the start-up costs and the total cost of ownership (TCO). It usually includes operating costs, maintenance costs, and fuel use. The FCYJ-4D diesel scooptram costs less to buy and runs over time than the R1700G. So, we can see that FCYJ-4D is a good choice from an economic point of view. How to choose the best Underground Mining Loader? You must select the right scoop tram for your project for two reasons. First, the safety of the miners is the most important thing in any mining activity. Because of this, you must choose the best LHD with the highest safety features. You should also check whether it can help lower the risk of harm and accidents. Second, productivity & operating expenses are also crucial in mining activity. Your chosen equipment's efficiency generally drives these two factors. Your project needs a scoop tram that can always and effectively do its job. So, remember the following things when selecting an underground mining loader. Safety Features First and foremost, prioritize loaders with safety features. You can check for safe cabins and ergonomic designs. It typically improves worker's safety. In addition, it also reduces the risk of accidents. Equipment Efficiency Check how fast the scoop tram goes, how much it can carry, and how much fuel it uses. Do you think it fits your needs? Pick the right spec. So, you can ensure that efficiency and cost-effectiveness are at their best. You should also check the durability and reliability of the loader. It generally determines the scoop tram's expected life span. Evaluate the total cost of ownership. You can consider the purchase price, maintenance costs, fuel consumption and resale value. Brand Reputation Finally, check the customer response on third-party websites. This reasonably ensures long-term satisfaction with the chosen loader. Cat R1700G underground mining loader and Fucheng FCYJ-4D are both better at what they do. FCYJ-4D is usually better for total productivity and fuel efficiency, though. On top of that, it is cheaper for different mining uses. CatR1700G might be a good choice for larger-scale mining tasks. On the other hand, the Fucheng FCYJ-4D might be better for middle to small-scale production.
It is the vitamin responsible for supplying the bones with calcium and phosphorous, which are the basis of bone formation, as the bone-building cells form the building blocks of their bones. And we get 50% of our needs from it through exposure to the sun, as ultraviolet rays convert cholesterol under the skin into vitamin D3, and we get the other 50% of plant or animal foodstuffs, as animals are the most important, because they contain large quantities of it, and it is in the form of D3, for example, all kinds of proteins, especially liver and egg yolks. As for vegetarianism, it is in the form of D2 and transformed into D3 in the stomach and then absorbed in the second part of the twelve in the presence of bile. After absorption, it is stored in the liver until its use. It is activated in two stages: one in the liver and the other in the kidney.
Standardized Bar Codes Can Make Complex Supply Chains More Transparent (1 April 2022 – Europe) Increased use of bar codes for international trade can force global supply chains to become more robust and improve the ability to verify environmental, social and governance (ESG) standards. Broader applications of the nearly five decade old system of barcode identification standards would force complex interconnected global supply chains to become more environmentally and socially sustainable, improve safety and security for key goods like food and medicine and generally make trade more efficient, sustainable and inclusive. The non-profit global organization in charge of barcode standards that make the technology possible, known as GS1, is joining with governments and multinational organizations to spread its use throughout global supply chains and make the information contained in bar codes more accessible. So far, the European Union (EU), the United States and the People's Republic of China (PRC) have begun using GS1 standard identification tools at their borders. Only one in four Asia and Pacific economies have either adopted the GS1 standards for their borders or are actively considering adoption. "To keep goods moving, to identify and fix problems within supply chains and for less red tape and hassle for smaller companies at borders, that needs to change" stated ADB's Head of Trade and Supply Chain Finance Program, Steven Beck. "Despite its success so far, the bar code needs to continue its penetration into the global economy to make global supply chains more robust, and to underpin our ability to verify social and environmental standards" Beck added.
Enjoy complimentary shipping on orders over Rs 8,000. Use code: NEW20 to receive a 20% discount on your first purchase! The world of fashion is constantly evolving, and Bollywood celebrities play a significant role in shaping trends and influencing what we wear. In India, the influence of celebrities on workwear fashion is particularly strong. Bollywood stars are known for their impeccable style and ability to effortlessly carry any outfit, making them trendsetters for millions of people. From stylish blazers to elegant sarees, their fashion choices have a direct impact on the clothing industry and workplace fashion. This blog explores the influence of Bollywood celebrities on workwear fashion in India and decodes their style secrets for a professional yet fashionable look. Bollywood celebrities have a massive impact on fashion trends, and this influence extends to workwear fashion in India. Their style choices are carefully observed by fashion enthusiasts and are often replicated in workplaces across the country. Whether it's the saree draping style of Deepika Padukone or the power suits adorned by Priyanka Chopra, Bollywood celebrities have elevated the standards of workwear fashion. Their influence goes beyond just the clothes they wear. Bollywood celebrities are also trendsetters when it comes to hairstyles, makeup, and accessories. From sleek buns to statement necklaces, their complete looks are curated to perfection. In the next section, we will explore some popular Bollywood celebrities and their impact on workwear fashion in India. Stay tuned to unravel the secrets of their style and learn how to incorporate them into your professional wardrobe. Workwear fashion has become increasingly popular in India, thanks in large part to the influence of Bollywood celebrities. As more and more individuals are entering the workforce and embracing their professional lives, the need to dress appropriately and stylishly for work has gained significant importance. Previously, workwear fashion in India was limited to traditional attire such as sarees and suits. However, with the emergence of Bollywood celebrities as style icons, there has been a shift towards embracing modern and global trends in the workplace. This shift can be attributed to the desire to make a strong impression and stand out in a competitive professional environment. It is no longer enough to simply dress professionally, individuals now strive to express their style and make a fashion statement while adhering to work dress codes. This has resulted in a more diverse and contemporary workwear fashion scene, influenced by the likes of Deepika Padukone, Priyanka Chopra, and many others. In the upcoming sections, we will delve into specific Bollywood celebrities and explore their unique contributions to workwear fashion in India. We will discuss how they have redefined traditional workwear and introduced fresh and exciting trends that professionals can take inspiration from. So, whether you're a working professional looking to revamp your work wardrobe or simply a fashion enthusiast interested in decoding the latest workwear fashion trends, this blog series will provide you with all the insights you need. Stay tuned as we unravel the secrets of Bollywood celebrities' style and learn how to incorporate their fashion choices into our professional lives. Bollywood celebrities have become more than just entertainers, they have evolved into influential style icons for professionals in India. Many working individuals turn to their favorite celebrities for fashion inspiration when it comes to their workwear wardrobe. Whether it's Deepika Padukone's effortless and chic office looks or Priyanka Chopra's bold and experimental outfits, these celebrities have redefined workwear fashion for the modern professional. By following the style choices of these celebrities, professionals can make a lasting impression with their fashion choices in the workplace. Celebrities like Alia Bhatt, Kareena Kapoor Khan, and Sonam Kapoor Ahuja have also made significant contributions to workwear fashion in India by introducing new trends, experimenting with colors, and breaking traditional norms. In the next few sections, we will explore the fashion evolution of these celebrities and how they have influenced workwear fashion in India. From decoding their signature looks to providing practical tips on how to incorporate their style into your own work wardrobe, we have all the information you need to stay on-trend and confident in the workplace. So, get ready to take your workwear fashion game to the next level with insights from your favorite Bollywood celebrities. In this section, we will delve into some iconic Bollywood workwear looks and decode the style choices of our favorite celebrities. From power suits to elegant sarees, these celebrities have showcased a variety of looks that are not only fashionable but also professional. 1. Deepika Padukone's Power Suits: Deepika is often seen sporting power suits with confidence and grace. Her tailored blazers paired with matching trousers or skirts create a strong and contemporary look, perfect for any business meeting or formal event. 2. Priyanka Chopra's Fusion Avatars: Priyanka's fusion ensembles combine Indian and Western elements effortlessly. From pairing traditional sarees with chic blouses to accessorizing her Western outfits with Indian statement pieces, she shows us how to add a touch of cultural flair to our workwear wardrobe. 3. Alia Bhatt's Casual Chic: Alia's casual yet chic workwear outfits are ideal for a more relaxed office environment. She often opts for stylish jumpsuits, tailored shorts, and relaxed blouses, making comfort and fashion equal priorities. 4. Kareena Kapoor Khan's Classic Elegance: Kareena's classic and elegant workwear looks are timeless. She embraces traditional Indian wear like embroidered kurtas, paired with tailored trousers or palazzos, creating a sophisticated and refined aesthetic. 5. Sonam Kapoor Ahuja's Experimental Flair: Sonam's experimental approach to fashion has made her a trailblazer in workwear fashion. From bold patterns to unconventional silhouettes, she encourages professionals to embrace their individuality and think outside the box when it comes to their workwear choices. By decoding these iconic looks, we hope to inspire you to incorporate elements of their style into your own workwear wardrobe. Stay tuned for our next section, where we provide practical tips on how to recreate these celebrity-inspired looks and make them your own. While it's important to stay true to your personal style and adhere to your workplace's dress code, there are ways to infuse a touch of Bollywood glamour into your professional attire. Firstly, consider experimenting with colors and prints. Bollywood celebrities are known for their bold and vibrant fashion choices, so don't shy away from incorporating pops of color or statement prints into your workwear outfits. You can do this by adding a colorful blouse to a neutral suit or opting for a patterned skirt paired with a simple blouse. Secondly, don't be afraid to play with accessories. Celebrities like Priyanka Chopra and Sonam Kapoor Ahuja often accessorize their workwear looks with statement jewelry or unique bags. Adding a statement necklace or a pair of statement earrings to your outfit can instantly elevate your overall look and make it more Bollywood-inspired. Lastly, don't forget about the power of tailoring. Bollywood celebrities always ensure their outfits fit them perfectly, and you should do the same. Invest in well-fitted blazers, trousers, and dresses to showcase a polished and put-together appearance. By incorporating these tips into your workwear wardrobe, you can confidently channel the Bollywood style and make a statement in your professional environment. Remember, while it's important to stay true to your personal style and adhere to your workplace's dress code, there are ways to infuse a touch of Bollywood glamour into your professional attire. Experiment with colors and prints, play with accessories and invest in well-fitted clothing to showcase a polished and put-together appearance. Fashion has the power to empower and boost confidence, and by embracing Bollywood-inspired workwear fashion, you can elevate your professional image and make a lasting impression. So go ahead, channel your favorite celebrity's style, and conquer the workplace with style and grace! As you seek to channel the elegance and style of your favorite Bollywood icons, discover the exquisite collection at Reves La Veste. Their Classics line harmoniously blends contemporary trends with timeless elegance, mirroring the trends set by Bollywood celebrities. Whether you're looking for an outfit that makes a bold statement in the boardroom or a versatile piece for daily wear, Reves La Veste offers a curated selection that aligns seamlessly with the sophistication and flair of Bollywood-inspired fashion. Explore Reves La Veste's collection today, and take the first step towards reinventing your professional wardrobe with a touch of celebrity-inspired elegance. So go ahead, draw inspiration from your favorite Bollywood icons, and conquer your workplace with style and grace – all while dressed in the impeccable creations from Reves La Veste.
Connectors help in improving the quality of sentence structure while creating complex sentences.Also, it helps connect one thought to the other. Thus, giving the conversation a logical sequence. IELTS Speaking Sample Part 1 Useful vocabulary for expressing your opinion a. For stating a direct opinion - In my opinion … - From my point of view … - As far as I'm concerned… - I believe that… For Example, - Is science a popular subject at your university? Answer. Very Popular, I believe that there are about 400 students studying science at King's and in addition, many parents want that their children should study science as it carries a lot of job assurance after finishing the course. - Do you enjoy studying it? Answer. Science is vast. In my opinion, it is interesting because you can relate it with you and your daily life. The section of Biology interests me the most. b. Vocabulary for expressing agreement: - I quite agree that…. - I could not agree more….. - You're absolutely right - I am in agreement….. - I completely agree that….. - Yes, I agree…. - I strongly agree that….. - I totally agree with the given idea that….. - Exactly…. - I am quite inclined to the opinion that….. - I agree with the opinion that… - So do I…. - I concur with the group who believe that….. - I accept that….. - That's true… - I accept the fact that….. - I consent that….. - Neither do I….. - I approve the idea of….. For Example, - Do many people visit your hometown? Answer. Tourists visit to see some of the old monuments but not much. The main reason behind this is the lack of development and in fact, very less number of people knows about the place. I quite agree that it's not one of the famous places but still worth visiting as it unfolds the beauty of history. - How has your hometown changed over the years? Answer. Since I was a child the town has almost doubled in size and population but I accept that the people's attitude towards life has not changed which has lead to the lack of improvement in the city. c. Vocabulary for expressing disagreement: - I strongly disagree that….. - I disagree with the opinion that…. - My own opinion contradicts with….. - I disagree with the statement of….. - I totally disagree with the given idea that….. - However, my opinion is different from….. - I quite oppose the opinion of….. - I completely disagree with….. - It's unjustifiable to say that…… - I disagree with the group of people who believe that….. - I disapprove that….. - On the contrary…… - I totally do not accept the fact that….. उदाहरण के लिए, - Have you ever bought clothes online? Answer. No because I don't trust these websites and I quite oppose the opinion of the society that online shopping can replace the traditional way of purchasing. - Do people from your country think fashion is important? Answer. Yes and more now. I have noticed that people follow trends blindly and don't even care whether a particular outfit is looking good on them or not. But I strongly disagree that fashion is more important than comfort. d. Vocabulary for expressing partial agreement: - To some extent….. - More or less….. - In a way….. - So to speak….. - Up to a point I agree….. - I agree to the given statement to some extent….. उदाहरण के लिए, - How important is internet to you? Answer. Not much important as I am not working. In a way, I use it to do some search for my children's homework. - Do you use apps? Answer. Not actually, But it becomes very difficult to avoid it as life is moving towards digital world. So to speak, I use it sometimes for booking a taxi or ordering grocery. e. Vocabulary for presenting time or sequence: - Last/ Lastly….. - First/ Firstly….. - Second/ Secondly….. - Third/ Thirdly….. - At the same time….. - Meanwhile….. - Then….. - Since….. - As soon as….. - After this / that….. - When…… - Before….. - After….. - Afterwards ….. - During….. - While….. - Following this….. - Simultaneously….. उदाहरण के लिए, - Do you like watching television? Answer. Yes, I love watching movies on television and during breaks I try to finish my home chores. - What was your favourite show when you were a child? उत्तर। Since I was a child, I was attracted to cartoons and loved watching Tom and Jerry. Useful vocabulary for each part a. For introduction - Certainly….. - Definitely….. - Doubtlessly….. - Undoubtedly….. - Without any doubt….. - No doubt….. - Of course…. उदाहरण के लिए - Do you like playing sports? उत्तर। Of course, I love playing cricket. - Do you have a healthy diet? Answer. Yes, I am very conscious of what am I eating. Without any doubt, I follow my diet plan made by my dietician. b. For body paragraphs when adding more information to support your opinion - And….. - However… - Moreover….. - Furthermore….. - In addition….. - Also….. - Similarly….. - In a similar fashion….. - Likewise….. - Though… - Although.. - As long as… - Even….. - Too…. - Besides….. - As well as…. - What's more….. - Again…. उदाहरण के लिए, - How many hours do you spend reading? Answer. I usually read before sleeping in the night. अलावा this, I like reading while travelling. - Do you think it's important to be punctual? Answer. Yes, it's very important to be on time in life as it is one of the basic manners. इसके अतिरिक्त, I don't like to keep people waiting. c. For conclusion - All in all - Last/ Lastly….. - In the end - To sum up - To conclude - In conclusion - To summarize - In summary - Summarizing it - We can end it by - We can conclude by… उदाहरण के लिए, - Is there anything you would like to change about your flat? Answer. I would love to have a big balcony where I can put some chairs and sit in the evening while having tea. Lastly, I would like to decorate it with plants. - Is it important for children to play sports? Answer. Definitely, sports not only keep them healthy but also inculcate discipline in life. It makes their mind constructive and gives them a routine in their day to day activities. में end, I would also say that sports build up confidence and make them hard working. IELTS Speaking sample part 2 Describe a holiday you enjoyed. You should say When and where you went Who you went with What you did on the holiday And explain why you found this particularly holiday enjoyable. प्रतिमान उत्तर: During the month of April 2014, I visited Phuket in Thailand with my family. It was a planned holiday और I was very excited about the trip. The flight was of around 5 hours and my son enjoyed a lot as it was his first flight. इसके अतिरिक्त, Thailand was always one of my dream destination. The capital city of Thailand is Bangkok and it is located in the centre of the country. We took another flight from Bangkok and finally reached Phuket. Phuket is full of beaches and they are extremely beautiful. The sand is white and the water is clear. Next day we went to Phi Phi island where we took a motorboat on rent and after reaching in the middle of the sea, we did snorkelling. It was a memorable experience and it is difficult for me to put it into words. It seemed like there is another world that exits under water. I would love to go again and enjoy the waves of sea. In my opinion, Thailand is undoubtedly a worth visiting destination. IELTS Speaking sample part 3 The examiner will now discuss one or two more general questions related to the same topic. Question1. Why do people go on holiday? उत्तर। I believe that people go on holidays to energize themselves. Question2. How important is it for families to go on holiday together? उत्तर। In my opinion, it is very significant as it strengthens the bond. Question3. Is it better to take a holiday in your own country or in a foreign country? Why? उत्तर। पहले तो, I would say that enjoying a trip is more important than the location. हालांकि, I would also say that location preference may differ according to the group of people you are going with. Like if you are going with your friends then you may want to explore the place to the fullest so a foreign country may be better लेकिन if you are going with your family then having fun is the ultimate motive of your vacation. All in all, location hardly matters. Which part you find the easiest in using connectors?
Dehydration in dogs can be caused by insufficient water intake and excessive heat exposure. Other factors can contribute to dehydration, such as illness or medications. Ensuring your dog stays hydrated is vital for overall health and well-being. It's essential to recognize the signs of dehydration in your furry friend and take prompt action to rehydrate them. By understanding the causes of dehydration in dogs, you can help prevent this common issue. Providing fresh water regularly and monitoring your dog's hydration levels are simple yet crucial steps in maintaining their health. Additionally, being aware of potential triggers like hot weather or strenuous activity can help you protect your pet from dehydration-related complications. Common Causes Dehydration in dogs can be caused by various factors. Inadequate water intake is a common cause, so it's important to ensure that your dog has access to fresh water at all times. During periods of extreme weather or vigorous exercise, dogs can become dehydrated due to excessive heat or exercise. Additionally, illness and vomiting can lead to dehydration as the body loses fluids. Keeping a close eye on your dog's water consumption and behavior can help prevent dehydration and ensure their well-being. Credit: veterinaryemergencygroup.com Environmental Factors Dehydration in dogs can be caused by environmental factors such as weather conditions. Hot temperatures and low humidity contribute to dehydration. Engaging in prolonged outdoor activities can also lead to dehydration. Behavioral Factors Dogs can become dehydrated due to various behavioral factors. One such factor is their preference for dirty water sources. Dogs may have a tendency to drink from stagnant ponds, puddles, or even dirty dishes. This can increase the risk of dehydration as the water from these sources may be contaminated and unhealthy for consumption. Another factor that can contribute to dehydration is competition with other animals. In multi-pet households or in outdoor settings where dogs interact with other animals, they may feel the need to compete for water resources. This can lead to decreased intake of water and ultimately result in dehydration. It is important for dog owners to encourage their pets to drink clean and fresh water regularly to prevent dehydration-related health issues. Credit: www.aecmemphis.com Dietary Factors Dehydration in dogs can be caused by dietary factors such as a low-moisture diet. Dogs need proper hydration, so a dry diet may lead to dehydration. Additionally, high-salt treats can further contribute to this issue. It is vital to provide access to clean, fresh water at all times. Ensuring that the dog's diet has adequate moisture and limiting high-salt treats can help prevent dehydration. Be mindful of the water intake and adjust the diet accordingly to keep your four-legged friend properly hydrated. Health Conditions Dogs can get dehydrated due to kidney disease which affects their ability to concentrate urine. Diabetes can also contribute to dehydration in dogs as it leads to increased urination. \| Preventive Measures Proper Hydration Awareness: Ensuring your dog has access to fresh water at all times is crucial in preventing dehydration. It's important to be aware of the signs of dehydration in dogs, such as dry gums, lethargy, and sunken eyes. Monitor your dog's water intake, especially during hot weather or strenuous activity. Encouraging your dog to drink more water can also help prevent dehydration. Adding water to your dog's food or offering ice cubes as treats can help increase their fluid intake. Additionally, being attentive to any changes in your dog's drinking habits or behavior can help identify dehydration early, allowing for prompt intervention. Frequently Asked Questions What Illness Causes Dehydration In Dogs? Dehydration in dogs can be caused by various illnesses, such as kidney disease, diabetes, and gastrointestinal issues. How Do You Fix A Dehydrated Dog? To fix a dehydrated dog, provide them with clean and fresh water in small quantities frequently. Encourage them to drink by adding flavor to the water or using ice cubes. Consult a veterinarian if the dehydration persists or if the dog shows other concerning symptoms. Can A Dog Drink Water And Still Be Dehydrated? Yes, a dog can still be dehydrated even if it drinks water. Signs include dry gums, lethargy, and sunken eyes. What Dog Breeds Are Prone To Dehydration? Some dog breeds prone to dehydration include Bulldogs, Pugs, Boxers, and Cavalier King Charles Spaniels. These breeds often have difficulty regulating body temperature and may require extra attention to ensure they stay hydrated. Regular water intake and shade are essential for preventing dehydration in these breeds. Dehydration in dogs can result from various factors like illness, heat, or insufficient water intake. Recognizing the signs early is crucial for timely intervention. By understanding the causes and taking preventive measures, dog owners can ensure their furry companions stay hydrated and healthy. Prioritizing hydration is key. Hello, I'm Daniel Johnson. I Studied animal science at the University of Florida. I am a seasoned veterinarian deeply committed to ensuring the health and happiness of every dog. With extensive expertise in dog health, I contribute my knowledge to Dog Advisor Pro to help dog owners understand and address their pet's health concerns. My passion is making veterinary advice accessible and understandable to all, allowing dog owners to provide the best care for their furry friends.
Exploring marine environments poses unique challenges that require specialized technological solutions. For example, navigating in deep waters, amid strong currents, and with limited visibility, often requires creative and overengineered strategies. The primary focus of the ORUS laboratory is on the advancement of ocean robotics for ocean research. We pursue research in essential areas, including enhanced navigation, guidance, autonomous mission control for single and multiple vehicles, multibeam sonar-based control, machine learning-enhanced decision making, and sophisticated cooperative control for fleets of ocean vehicles. Our research applies a wide range of rigorous and structured mathematical tools to a variety of autonomous ocean vehicles, each streamlined for a different task. This currently includes the ORVIS Autonomous Underwater Vehicle (AUV) and the DELMAC Autonomous Surface Vehicle (ASV), the latter equipped with an extensive sensor suite for strategic surface-level missions, as well as for support and coordination in missions involving underwater platforms. Our fleet of vehicles will also include, in due course: Intervention Autonomous Underwater Vehicles (I-AUVs) equipped with advanced navigation and manipulation capabilities; highly efficient torpedo-like vehicles for detailed ocean floor mapping; and gliders for long-duration oceanographic data collection. We harness all these different technologies for a variety of critical applications, for example, comprehensive studies of underwater ecosystems, creation of marine habitat maps, collection and analysis of environmental data, accurate pollution assessments, identification and mitigation of environmental hazards, exploration and study of submerged historical sites with least obtrusive gear and techniques, etc. At the ORUS laboratory, we believe in unleashing the untapped potential of ocean robotics to address the multifaceted challenges and opportunities presented by marine environments. The autonomous vehicles at ORUS Lab DELMAC Autonomous Surface Vehicle Autonomous marine craft are steadily playing an ever-increasing role in the study of the ocean. Among these, autonomous surface vehicles (ASVs) are becoming quite appealing for operations in shallow waters. Equipped with advanced navigation and control systems, sophisticated acoustic sensors, and systems for mission programming and execution, they afford end-users the tools that are needed to automatically map the seabed at an unprecedented scale without constant supervision of human operators. ASVs also play an important role in the study of new approaches for underwater exploration and mapping, in that they allow assessing proper methodologies for the electrical/mechanical integration of new sensors. In the scope of the ORUS Lab of the University of Macau, we foresee the use of advanced acoustic sensor suites to accurately map shallow water regions. An important step in this direction has been the myriad of tests in the lakes of the University of Macau using the DELMAC ASV in shallow water operations, vital for assessing the performance of our navigation and control algorithms. The DELMAC craft is a small boat 1.8 m long and 0.8 m wide, weighing approximately 30 kg. For propulsion, the vehicle is equipped with two bladed propellers driven by electrical motors. The maximum rated speed of the vehicle with respect to the water is 5 knots. The DELMAC is equipped with on-board resident systems for navigation, guidance and control, as well as mission control. Navigation is achieved by integrating motion sensor data obtained from an attitude reference unit and a DGPS (Differential Global Positioning System) or, for higher accuracy, a RTKGPS (Real Time Kinematics Global Positioning System). Transmissions between the ASV and its support vessel – or a control centre installed on-shore – are achieved via an Ethernet radio link capable of long-distance communication, up to 10 km, at high data rates. Future plans include using the DELMAC for bathymetric operations and sea floor characterization resorting to sensor suites that include sonar profiler or small size multibeam sonar. ORVIS Autonomous Underwater Vehicle ORVIS is an AUV intended to perform shallow water interventions in Macau waters for accurate shallow water bathymetry, inspection of underwater structures, studies of marine biodiversity, assessment of the human impact on the marine environment, detection and localization of toxic spills, to name just a few. In view of stringent practical requirements in some complex underwater missions, where current levels of autonomy are still inadequate to ensure vehicle safety and correct operation, ORVIS can also be used as a remotely operated vehicle (ROV). The ORVIS AUV prototype was fully developed, from concept and design to assembling and programming, at the University of Macau. The vehicle is equipped with algorithms for high accuracy bathymetry and seabed mapping based on affordable multibeam imaging and doppler velocity log sonars; novel nonlinear trajectory tracking and path following controllers with bottom following and obstacle avoidance capabilities that enables it to perform accurate bathymetry with full seabed coverage of the target areas in the presence of unexpected static or even dynamic obstacles; and fault detection and isolation tools. The ORVIS AUV sensor suite includes a Microstrain Inertial Measurement Unit, a GPS receiver with RTK corrections, an Oculus 1200d Multibeam Imaging sonar, a WaterLinked A50 Doppler Velocity Log, a WaterLinked Acoustic Modem, a PicoBoard52R Single Board Computer, and a GPU board NVIDIA Jetson Nano, all integrated in Robotic Operation System (ROS) over Linux. It is powered by two sets of lithium polymer batteries, allowing the vehicle to carry out missions lasting up to 4 hours. The design and construction of the ORVIS AUV prototype was carried out by members of the ORUS team with solid experience in the development of ocean robotic vehicles. In particular, the design of the mechanical hull and propulsion system took into consideration the constraints imposed by the desired vehicle's autonomy and hydrodynamic performance, space for the equipment selected, transportability and operationality. The shape and weight distribution of the vehicle was obtained in function of the required open loop stability and closed loop manoeuvrability, for the types of envisioned missions. Furthermore, particular care was exercised in the analysis of the impact of the metacentric height on the vehicle pitch and roll dynamics which are determinant in the vehicle behaviour while performing bottom tracking in bathymetry missions.
Title : Target-Based Screen Against a Periplasmic Serine Protease That Regulates Intrabacterial pH Homeostasis in Mycobacterium tuberculosis - Zhao_2015_ACS.Chem.Biol_10_364 \| Author(s) : Zhao N , Darby CM , Small J , Bachovchin DA , Jiang X , Burns-Huang KE , Botella H , Ehrt S , Boger DL , Anderson ED , Cravatt BF , Speers AE , Fernandez-Vega V , Hodder PS , Eberhart C , Rosen H , Spicer TP , Nathan CF \| Ref : ACS Chemical Biology , 10 :364 , 2015 \| Abstract : Mycobacterium tuberculosis (Mtb) maintains its intrabacterial pH (pHIB) near neutrality in the acidic environment of phagosomes within activated macrophages. A previously reported genetic screen revealed that Mtb loses this ability when the mycobacterial acid resistance protease (marP) gene is disrupted. In the present study, a high throughput screen (HTS) of compounds against the protease domain of MarP identified benzoxazinones as inhibitors of MarP. A potent benzoxazinone, BO43 (6-chloro-2-(2'-methylphenyl)-4H-1,3-benzoxazin-4-one), acylated MarP and lowered Mtb's pHIB and survival during incubation at pH 4.5. BO43 had similar effects on MarP-deficient Mtb, suggesting the existence of additional target(s). Reaction of an alkynyl-benzoxazinone, BO43T, with Mycobacterium bovis variant bacille Calmette-Guerin (BCG) followed by click chemistry with azido-biotin identified both the MarP homologue and the high temperature requirement A1 (HtrA1) homologue, an essential protein. Thus, the chemical probe identified through a target-based screen not only reacted with its intended target in the intact cells but also implicated an additional enzyme that had eluded a genetic screen biased against essential genes. \| ESTHER : Zhao_2015_ACS.Chem.Biol_10_364 \| PubMedSearch : Zhao_2015_ACS.Chem.Biol_10_364 \| PubMedID: 25457457 \| Title : Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes - Adibekian_2012_J.Am.Chem.Soc_134_10345 \| Author(s) : Adibekian A , Martin BR , Chang JW , Hsu KL , Tsuboi K , Bachovchin DA , Speers AE , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Hodder PS , Rosen H , Cravatt BF \| Ref : J Am Chem Soc , 134 :10345 , 2012 \| Abstract : The development of small-molecule inhibitors for perturbing enzyme function requires assays to confirm that the inhibitors interact with their enzymatic targets in vivo. Determining target engagement in vivo can be particularly challenging for poorly characterized enzymes that lack known biomarkers (e.g., endogenous substrates and products) to report on their inhibition. Here, we describe a competitive activity-based protein profiling (ABPP) method for measuring the binding of reversible inhibitors to enzymes in animal models. Key to the success of this approach is the use of activity-based probes that show tempered rates of reactivity with enzymes, such that competition for target engagement with reversible inhibitors can be measured in vivo. We apply the competitive ABPP strategy to evaluate a newly described class of piperazine amide reversible inhibitors for the serine hydrolases LYPLA1 and LYPLA2, two enzymes for which selective, in vivo active inhibitors are lacking. Competitive ABPP identified individual piperazine amides that selectively inhibit LYPLA1 or LYPLA2 in mice. In summary, competitive ABPP adapted to operate with moderately reactive probes can assess the target engagement of reversible inhibitors in animal models to facilitate the discovery of small-molecule probes for characterizing enzyme function in vivo. \| ESTHER : Adibekian_2012_J.Am.Chem.Soc_134_10345 \| PubMedSearch : Adibekian_2012_J.Am.Chem.Soc_134_10345 \| PubMedID: 22690931 \| Title : A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors - Lone_2011_J.Am.Chem.Soc_133_11665 \| Author(s) : Lone AM , Bachovchin DA , Westwood DB , Speers AE , Spicer TP , Fernandez-Vega V , Chase P , Hodder PS , Rosen H , Cravatt BF , Saghatelian A \| Ref : Journal of the American Chemical Society , 133 :11665 , 2011 \| Abstract : Peptidases play vital roles in physiology through the biosynthesis, degradation, and regulation of peptides. Prolyl endopeptidase-like (PREPL) is a newly described member of the prolyl peptidase family, with significant homology to mammalian prolyl endopeptidase and the bacterial peptidase oligopeptidase B. The biochemistry and biology of PREPL are of fundamental interest due to this enzyme's homology to the biomedically important prolyl peptidases and its localization in the central nervous system. Furthermore, genetic studies of patients suffering from hypotonia-cystinuria syndrome (HCS) have revealed a deletion of a portion of the genome that includes the PREPL gene. HCS symptoms thought to be caused by lack of PREPL include neuromuscular and mild cognitive deficits. A number of complementary approaches, ranging from biochemistry to genetics, will be required to understand the biochemical, cellular, physiological, and pathological mechanisms regulated by PREPL. We are particularly interested in investigating physiological substrates and pathways controlled by PREPL. Here, we use a fluorescence polarization activity-based protein profiling (fluopol-ABPP) assay to discover selective small-molecule inhibitors of PREPL. Fluopol-ABPP is a substrate-free approach that is ideally suited for studying serine hydrolases for which no substrates are known, such as PREPL. After screening over 300,000 compounds using fluopol-ABPP, we employed a number of secondary assays to confirm assay hits and characterize a group of 3-oxo-1-phenyl-2,3,5,6,7,8-hexahydroisoquinoline-4-carbonitrile and 1-alkyl-3-oxo-3,5,6,7-tetrahydro-2H-cyclopenta[c]pyridine-4-carbonitrile PREPL inhibitors that are able to block PREPL activity in cells. Moreover, when administered to mice, 1-isobutyl-3-oxo-3,5,6,7-tetrahydro-2H-cyclopenta[c]pyridine-4-carbonitrile distributes to the brain, indicating that it may be useful for in vivo studies. The application of fluopol-ABPP has led to the first reported PREPL inhibitors, and these inhibitors will be of great value in studying the biochemistry of PREPL and in eventually understanding the link between PREPL and HCS. \| ESTHER : Lone_2011_J.Am.Chem.Soc_133_11665 \| PubMedSearch : Lone_2011_J.Am.Chem.Soc_133_11665 \| PubMedID: 21692504 \| Gene_locus related to this paper: human-PREPL \| Title : Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors - Bachovchin_2011_Proc.Natl.Acad.Sci.U.S.A_108_6811 \| Author(s) : Bachovchin DA , Mohr JT , Speers AE , Wang C , Berlin JM , Spicer TP , Fernandez-Vega V , Chase P , Hodder PS , Schurer SC , Nomura DK , Rosen H , Fu GC , Cravatt BF \| Ref : Proc Natl Acad Sci U S A , 108 :6811 , 2011 \| Abstract : National Institutes of Health (NIH)-sponsored screening centers provide academic researchers with a special opportunity to pursue small-molecule probes for protein targets that are outside the current interest of, or beyond the standard technologies employed by, the pharmaceutical industry. Here, we describe the outcome of an inhibitor screen for one such target, the enzyme protein phosphatase methylesterase-1 (PME-1), which regulates the methylesterification state of protein phosphatase 2A (PP2A) and is implicated in cancer and neurodegeneration. Inhibitors of PME-1 have not yet been described, which we attribute, at least in part, to a dearth of substrate assays compatible with high-throughput screening. We show that PME-1 is assayable by fluorescence polarization-activity-based protein profiling (fluopol-ABPP) and use this platform to screen the 300,000+ member NIH small-molecule library. This screen identified an unusual class of compounds, the aza-beta-lactams (ABLs), as potent (IC(50) values of approximately 10 nM), covalent PME-1 inhibitors. Interestingly, ABLs did not derive from a commercial vendor but rather an academic contribution to the public library. We show using competitive-ABPP that ABLs are exquisitely selective for PME-1 in living cells and mice, where enzyme inactivation leads to substantial reductions in demethylated PP2A. In summary, we have combined advanced synthetic and chemoproteomic methods to discover a class of ABL inhibitors that can be used to selectively perturb PME-1 activity in diverse biological systems. More generally, these results illustrate how public screening centers can serve as hubs to create spontaneous collaborative opportunities between synthetic chemistry and chemical biology labs interested in creating first-in-class pharmacological probes for challenging protein targets. \| ESTHER : Bachovchin_2011_Proc.Natl.Acad.Sci.U.S.A_108_6811 \| PubMedSearch : Bachovchin_2011_Proc.Natl.Acad.Sci.U.S.A_108_6811 \| PubMedID: 21398589 \| Gene_locus related to this paper: human-PPME1 \| Title : Probe Development Efforts to Identify Novel Inhibitors of Protein Phosphatase Methylesterase-1 (PME-1) - Bachovchin_2010_Probe.Report__1 \| Author(s) : Bachovchin DA , Speers AE , Brown SJ , Spicer TP , Fernandez V , Ferguson J , Mohr JT , Murphy J , Fu GC , Cravatt BF , Hodder PS , Rosen H \| Ref : Probe Report , : , 2010 \| Abstract : Reversible protein phosphorylation networks play essential roles in most cellular processes. While over 500 kinases catalyze protein phosphorylation, only two enzymes, PP1 and PP2A, are responsible for more than 90% of all serine/threonine phosphatase activity. Phosphatases, unlike kinases, achieve substrate specificity through complex subunit assembly and post-translational modifications rather than number. Mutations in several of the PP2A subunits have been identified in human cancers, suggesting that PP2A may act as a tumor suppressor. Adding further complexity, several residues of the catalytic subunit of PP2A can be reversibly phosphorylated, and the C-terminal leucine residue can be reversibly methylated. Protein phosphatase methylesterase-1 (PME-1) is specifically responsible for demethylation of the carboxyl terminus. Methylesterification is thought to control the binding of different subunits to PP2A, but little is known about physiological significance of this post-translational modification in vivo. Recently, PME-1 has been identified as a protector of sustained ERK pathway activity in malignant gliomas. PME-1 knockout mice generated by targeted gene disruption result in perinatal lethality, underscoring the importance of PME-1 but hindering biological studies. The Scripps Research Institute Molecular Screening Center (SRIMSC), part of the Molecular Libraries Probe Production Centers Network (MLPCN), identified a potent and selective PME-1 inhibitor probe, ML174, by high-throughput screening using fluorescence polarization-activity-based protein profiling (FluoPol-ABPP). ML174, with an IC50 of 10 nM, is based on the aza-beta-lactam scaffold and is selective for PME-1 among serine hydrolases in human cell line proteomes as assessed by gel-based competitive-activity-based protein profiling. Among more than 30 serine hydrolase anti-targets, ML174 is selective at 1 muM. Additionally, ML174 was shown in situ to be highly active against PME-1 and to result in 85% reduction of demethylated PP2A. We previously reported a modestly potent 500 nM inhibitor that was selective for PME-1, the first reported selective PME-1 inhibitor. ML174 is 50 times more potent and from an entirely different structural and mechanistic class of inhibitors. Due to its much higher potency, ML174 has greater potential for use in long time-course in situ studies, and is a much better candidate for in vivo applications. \| ESTHER : Bachovchin_2010_Probe.Report__1 \| PubMedSearch : Bachovchin_2010_Probe.Report__1 \| PubMedID: 22834039 \| Title : Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9) - Bachovchin_2010_Bioorg.Med.Chem.Lett_20_2254 \| Author(s) : Bachovchin DA , Wolfe MR , Masuda K , Brown SJ , Spicer TP , Fernandez-Vega V , Chase P , Hodder PS , Rosen H , Cravatt BF \| Ref : Bioorganic & Medicinal Chemistry Lett , 20 :2254 , 2010 \| Abstract : We recently described a fluorescence polarization platform for competitive activity-based protein profiling (fluopol-ABPP) that enables high-throughput inhibitor screening for enzymes with poorly characterized biochemical activity. Here, we report the discovery of a class of oxime ester inhibitors for the unannotated serine hydrolase RBBP9 from a full-deck (200,000+ compound) fluopol-ABPP screen conducted in collaboration with the Molecular Libraries Screening Center Network (MLSCN). We show that these compounds covalently inhibit RBBP9 by modifying enzyme's active site serine nucleophile and, based on competitive ABPP in cell and tissue proteomes, are selective for RBBP9 relative to other mammalian serine hydrolases. \| ESTHER : Bachovchin_2010_Bioorg.Med.Chem.Lett_20_2254 \| PubMedSearch : Bachovchin_2010_Bioorg.Med.Chem.Lett_20_2254 \| PubMedID: 20207142 \| Gene_locus related to this paper: human-RBBP9 \|
Glaucoma Adherence in Latin America What can a medication event monitoring system device tell us about non-adherence in glaucoma patients? Ricardo Abe \| \| 3 min read \| Opinion Adherence to treatment in asymptomatic chronic diseases is a delicate matter. When it comes to glaucoma, research conservatively estimates that around 30 percent of patients will be non-adherent to treatment for various reasons, including forgetfulness, complexity of drug regimens, side-effects, insufficient disease awareness, and financial constraints. In Latin America, previous studies have not explored treatment adherence rates using objective metrics with monitoring devices – nor have they correlated these rates with glaucoma progression and loss to follow-up. It was our goal, then, to implement a medication adherence monitoring system to accurately measure adherence rates and identify potential risk factors associated with poor adherence (1). Our team first estimated the rate of glaucoma treatment adherence using medication monitoring devices in a group of patients. Though the rates of adherence were similar to previous studies from the US and Europe – around 28 percent non-adherence in our cohort of 110 patients, it is important to note that we didn't assess instillation techniques to evaluate whether patients were using the medication properly. In fact, patients in clinical studies monitored with devices may show higher adherence rates. We can therefore presume that the actual rates of true adherence might be lower than the numbers reported for patients in a real-world scenario. Our findings also discovered an association between the rates of adherence with glaucoma progression, loss to follow-up, and several other clinical variables. These factors include older age, low educational and income levels, lack of health insurance, and fewer years living with the disease. We believe that, going forward, it would be useful to examine possible side effects and the cost of the medication, alongside the implementation of a family or friends support system to remind patients of their treatment regimen. Healthcare providers must find solutions to minimize the risk of non-adherence to treatment. From an industry perspective, creating preservative-free glaucoma eye drops, offering cost-effective options, and expanding drug combination choices could mitigate the impact of poor adherence. On the clinician side, fostering stronger patient relationships to address concerns about glaucoma physiology and treatment necessity could promote greater treatment engagement. - L Oltramari, et al., "The association between glaucoma treatment adherence with disease progression and loss to follow-up," Sci Rep, 25, 14(2024): DOI: 10.1038/s41598-024-52800-2. Ophthalmologist at the Hospital Oftalmológico de Brasília.
The field of legal compliance spans various industries, including finance, healthcare, technology, and beyond. As businesses face increasingly stringent regulatory environments, the demand for skilled compliance officers continues to rise. However, excelling in this field requires more than just a basic understanding of laws and regulations; it demands a diverse set of skills and attributes. Let's delve into the essential skills necessary for a career in legal compliance. 1. Thorough Understanding of Regulations and Laws At the core of legal compliance lies a comprehensive knowledge of regulations and laws pertinent to the industry in which one operates. Whether it's data protection laws, anti-money laundering regulations, or healthcare compliance standards, compliance professionals must stay abreast of legislative changes and evolving best practices. This necessitates a commitment to ongoing education and professional development. 2. Analytical and Problem-Solving Skills Legal compliance often involves interpreting complex regulations and applying them to real-world scenarios. Compliance officers must possess strong analytical skills to assess risks, identify compliance gaps, and develop effective solutions. The ability to think critically and solve problems efficiently is invaluable in navigating the intricacies of regulatory compliance. 3. Attention to Detail In the realm of legal compliance, the devil truly lies in the details. A minor oversight or misinterpretation of a regulation can have significant repercussions for an organisation. Therefore, attention to detail is paramount for compliance professionals. Whether reviewing contractual agreements, conducting audits, or drafting policies, meticulous attention to detail is essential to ensure regulatory adherence and mitigate compliance risks. 4. Communication Skills Effective communication is essential for a career in legal compliance. Compliance officers must be able to articulate complex regulatory requirements clearly and concisely to various stakeholders, including senior management, employees, and regulatory authorities. Additionally, strong interpersonal skills are crucial for fostering collaboration across departments and facilitating a culture of compliance within an organisation. 5. Ethical Integrity Integrity lies at the heart of legal compliance. Compliance professionals must uphold the highest ethical standards and demonstrate unwavering integrity in their decision-making processes. They must navigate ethical dilemmas with transparency and integrity, always prioritising the interests of the organisation and its stakeholders while adhering to legal and regulatory requirements. 6. Adaptability and Flexibility The regulatory landscape is constantly evolving, with new laws and compliance standards emerging regularly. Compliance professionals must possess the agility to adapt to changing regulatory environments and pivot strategies accordingly. Flexibility is key to navigating unforeseen challenges and implementing effective compliance measures in response to evolving threats and regulatory changes. 7. Risk Management Skills Legal compliance is inherently tied to risk management. Compliance officers must possess a keen understanding of organisational risks and develop robust risk management frameworks to mitigate potential compliance breaches. This entails conducting risk assessments, implementing internal controls, and monitoring compliance metrics to proactively identify and address areas of vulnerability. 8. Technology Proficiency In an increasingly digitised world, technology plays a pivotal role in legal compliance efforts. Compliance professionals must leverage technology tools and platforms to streamline compliance processes, automate routine tasks, and enhance regulatory reporting capabilities. Proficiency in compliance software, data analytics, and information security protocols is essential for staying ahead in the compliance landscape. 9. Project Management Skills Legal compliance initiatives often involve multifaceted projects with various stakeholders and deadlines. Strong project management skills are indispensable for planning, executing, and monitoring compliance projects effectively. Compliance officers must be adept at setting goals, allocating resources, and managing timelines to ensure the timely and successful completion of compliance initiatives. 10. Continuous Learning and Adaptation To thrive in this challenging environment, compliance professionals must embrace a mindset of continuous learning and adaptation. Staying informed about emerging regulatory trends, attending industry conferences, and participating in professional development opportunities are essential for staying ahead of the curve and maintaining relevance in the field of legal compliance.
Injection molding control parameter assessment by nested Taguchi design of simulation experiments: a case study ILIOPOULOU Vasiliki, VOSNIAKOS George-Christopher download PDFAbstract. Injection molding of a polypropylene (PP) food packaging container is studied using a dedicated simulation program. Three successive Taguchi designs of experiments (DoE) are performed to identify the influence of control factors and to adjust their levels for optimal result. These are nested, each one narrowing down the decision space of its predecessor. In the first design (L27), seven control factors were considered: polymer material in terms of MFI, melt and mold temperature, maximum injection pressure, filling time, maximum packing pressure and packing time. Part weight, clamping force and a fictitious factor related to premature solidification of the material during packing were quality factors. In the next DoE (L27 again), for fixed material, the four most important process factors determined before are examined in more detail, adding cycle time as an extra quality factor. Dependence of results on melt temperature proved to be strong, so a third DoE (L9), examined a narrower temperature range. Calculation of S/N ratios and analysis of variance (ANOVA) led to optimization of control parameters through a weighted objective function. Polypropylene, Thin-Wall, Injection Molding, Taguchi Methods, Simulation Published online 4/24/2024, 10 pages Copyright © 2024 by the author(s) Published under license by Materials Research Forum LLC., Millersville PA, USA Citation: ILIOPOULOU Vasiliki, VOSNIAKOS George-Christopher, Injection molding control parameter assessment by nested Taguchi design of simulation experiments: a case study, Materials Research Proceedings, Vol. 41, pp 2757-2766, 2024 DOI: https://doi.org/10.21741/9781644903131-302 The article was published as article 302 of the book Material Forming Content from this work may be used under the terms of the Creative Commons Attribution 3.0 license. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. [1] G. Singh, A. Verma, A Brief Review on injection moulding manufacturing process, Materials Today: Proceedings, 4/2 (2017) 1423-1433. https://doi.org/10.1016/j.matpr.2017.01.164. [2] B. Catoen, H. Rees, Injection Mold Design Handbook, Hanser Publ., Munich, 2022. [3] C. Fernandes, A.J. Pontes, J.C. Viana, A. Gaspar‐Cunha,. Modeling and Optimization of the Injection‐Molding Process: A Review. Advances in Polymer Technology, 37/2 (2018) 429-449. https://doi.org/10.1002/adv.21683. [4] M.-L. Wang, R.-Y. Chang, and C.-H. Hsu, (Eds), Molding Simulation: Theory and Practice, Hanser Publ., Munich, 2022. [5] A. Mourya, A. Nanda, K. Parashar, Sushant, R. Kumar, An explanatory study on defects in plastic molding parts caused by machine parameters in injection molding process, Materials Today Proceedings 78 (2023) 656–661. https://doi.org/10.1016/j.matpr.2022.12.070. [6] A. Shenoy, D. R. Saini, Melt Flow Index: More Than Just a Quality Control Rheological Parameter. Part I, Advanced Polymer Technology 6 (1986) 1–58. https://doi.org/10.1002/ adv.1986.060060101. [7] I. Sapounas, G.-C. Vosniakos, G. Papazetis, A simulation-based robust methodology for operator guidance on injection moulding machine settings, International Journal of Interactive Design & Manufacturing 14 (2020) 519-533. https://doi.org/10.1007/s12008-020-00646-z. [8] M. Kavade, Parameter Optimization of Injection Molding of Polypropylene by using Taguchi Methodology, IOSR Journal of Mechanical and Civil Engineering 4 (2012) 49–58. https://doi.org/10.9790/1684-0444958. [9] G. Trotta, S. Cacace, Q. Semeraro, Optimizing process parameters in micro injection moulding considering the part weight and probability of flash formation, Journal of Manufacturing Processes 79 (2022) 250–258. https://doi.org/10.1016/j.jmapro.2022.04.048. [10] C.W. Su, W.J. Su, F.J. Cheng, G.Y. Liou, S.J. Hwang, H.S. Peng, H.Y. Chu, Optimization process parameters and adaptive quality monitoring injection molding process for materials with different viscosity, Polymer Testing, 109 (2022) 107526. https://doi.org/10.1016/j.polymertesting.2022.107526. [11] C.-P. Chen, M.-T. Chuang, Y.-H. Hsiao, Y.-K. Yang, C.-H. Tsai, Simulation and experimental study in determining injection molding process parameters for thin-shell plastic parts via design of experiments analysis, Expert Systems and Applications 36/7 (2009) 10752–10759. https://doi.org/10.1016/j.eswa.2009.02.017. [12] F. Hentati, I. Hadriche, N. Masmoudi, C. Bradai, Optimization of the injection molding process for the PC/ABS parts by integrating Taguchi approach and CAE simulation, The International Journal of Advanced Manufacturing Technology 104 (2019) 4353-4363. https://doi.org/10.1007/s00170-019-04283-z. [13] M. Moayyedian, A. Dinc, A. Mamedov, Optimization of Injection-Molding Process for Thin-Walled Polypropylene Part Using Artificial Neural Network and Taguchi Techniques, Polymers, 13(23) 2021, 4158. https://doi.org/10.3390/polym13234158. [14] V. Panneerselvam, F.M. Turan, Optimisation of Injection Moulding Process Parameter Using Taguchi and Desirability Function, In: M. Zakaria, A. Abdul Majeed, M. Hassan (eds) Advances in Mechatronics, Manufacturing, and Mechanical Engineering. Lecture Notes in Mechanical Engineering, (2021) 247–260, Springer. doi: 10.1007/978-981-15-7309-5_24 [15] B. Ravikiran, D.K. Pradhan, S. Jeet, D.K. Bagal, A. Barua, S. Nayak, 2022. Parametric optimization of plastic injection moulding for FMCG polymer moulding (PMMA) using hybrid Taguchi-WASPAS-Ant Lion optimization algorithm, Materials Today: Proceedings, 56 (2022) 2411-2420. https://doi.org/10.1016/j.matpr.2021.08.204. [16] R. Farooque, M. Asjad, S.J.A. Rizvi, A current state of art applied to injection moulding manufacturing process–a review, Materials Today: Proceedings, 43 (2021) 441-446. https://doi.org/10.1016/j.matpr.2020.11.967. [17] R.K. Roy, A primer on the Taguchi method. Society of Manufacturing Engineers, 2010.
Comment: MCS data shows UK on track for best year ever for renewable energy and heat installations Data from MCS showing that more households are installing heat pumps and solar panels in the UK than ever before By George Smeeton Last updated: Commenting on data from MCS showing that more households are installing heat pumps and solar panels in the UK than ever before [1] Jess Ralston, Head of Energy at the Energy and Climate Intelligence Unit (ECIU) said: "The gas crisis jeopardising the UK's security of supply and causing bills to rocket over the last year has clearly left its mark on the British public, who are quickly turning to net zero technologies like solar and heat pumps to gain energy independence. "As these technologies get more commonplace and likely cheaper, this trend is only going to grow, despite some unclear messaging and a lack of long term policy certainty around the Boiler Upgrade Scheme for heat pumps, for example. Delivering a stable plan for 2030 and beyond plus incentives for household technologies can help get the UK to be less reliant on gas, meaning that we have to import less from abroad as the North Sea continues to decline, and shielding ourselves from any future gas crises." Notes to editors: - The data from MCS (the Microgeneration Certification Scheme Service Company), published on Monday 14 August, shows that in the first six months of 2023, more than 120,000 certified solar panels, heat pumps and other renewable technologies were installed in UK homes, the highest number ever by this point in the year. For more information or for interview requests: George Smeeton, Head of Communications, ECIU, Tel: 07894 571 153, email: firstname.lastname@example.com
Year of publication Document Type - Article (11) - Doctoral Thesis (1) - Preprint (1) - English (13) Has Fulltext - yes (13) Is part of the Bibliography - no (13) - Canis lupus (2) - Non-invasive sampling (2) - Alburnoides bipunctatus (1) - Biodiversity (1) - Canis lupus familiaris (1) - Carnivores (1) - Conservation biogeography (1) - Conservation biology (1) - Dispersal capacity (1) - Divergence time estimate (1) Active species reintroduction is an important conservation tool when aiming for the restoration of biological communities and ecosystems. The effective monitoring of reintroduction success is a crucial factor in this process. Here, we used a combination of environmental DNA (eDNA) techniques and species distribution models (SDMs) to evaluate the success of recent reintroductions of the freshwater fish Alburnoides bipunctatus in central Germany. We built SDMs without and with eDNA presence data to locate further suitable reintroduction sites and potentially overlooked populations of the species. We successfully detected eDNA of A. bipunctatus at all reintroduction sites, as well as several adjacent sites mostly in downstream direction, which supports the success of reintroduction efforts. eDNA‐based species detection considerably improved SDMs for A. bipunctatus, which allowed to identify species presence in previously unknown localities. Our results confirm the usefulness of eDNA techniques as standard tool to monitor reintroduced fish populations. We propose that combining eDNA with SDMs is a highly effective approach for long‐term monitoring of reintroduction success in aquatic species. Background One of the central issues in ecology is the question what allows sympatric occurrence of closely related species in the same general area? The non-biting midges Chironomus riparius and C. piger, interbreeding in the laboratory, have been shown to coexist frequently despite of their close relatedness, similar ecology and high morphological similarity. Methodology/Principal Findings In order to investigate factors shaping niche partitioning of these cryptic sister species, we explored the actual degree of reproductive isolation in the field. Congruent results from nuclear microsatellite and mitochondrial haplotype analyses indicated complete absence of interspecific gene-flow. Autocorrelation analysis showed a non-random spatial distribution of the two species. Though not dispersal limited at the scale of the study area, the sister species occurred less often than expected at the same site, indicating past or present competition. Correlation and multiple regression analyses suggested the repartition of the available habitat along water chemistry gradients (nitrite, conductivity, CaCO3), ultimately governed by differences in summer precipitation regime. Conclusions We show that these morphologically cryptic sister species partition their niches due to a certain degree of ecological distinctness and total reproductive isolation in the field. The coexistence of these species provides a suitable model system for the investigation of factors shaping the distribution of closely related, cryptic species. Although it has been suggested that temperature increase may alter the toxic potential of environmental pollutants, few studies have investigated the potential risk of chemical stressors for wildlife under Global Climate Change (GCC) impact. We applied a bifactorial multigeneration study in order to test if GCC conditions alter the effects of low pesticide concentrations on life history and genetic diversity of the aquatic model organism Chironomus riparius. Experimental populations of the species were chronically exposed to a low concentration of the fungicide pyrimethanil (half of the no-observed-adverse-effect concentration: NOAEC/2) under two dynamic present-day temperature simulations (11.0–22.7°C; 14.0–25.2°C) and one future scenario (16.5–28.1°C). During the 140-day multigeneration study, survival, emergence, reproduction, population growth, and genetic diversity of C. riparius were analyzed. Our results reveal that high temperature and pyrimethanil act synergistically on the midge C. riparius. In simulated present-day scenarios, a NOAEC/2 of pyrimethanil as derived from a life-cycle toxicity test provoked only slight-to-moderate beneficial or adverse effects on C. riparius. In contrast, exposure to a NOAEC/2 concentration of pyrimethanil at a thermal situation likely for a summer under GCC conditions uncovered adverse effects on mortality and population growth rate. In addition, genetic diversity was considerably reduced by pyrimethanil in the future scenario, but only slightly under current climatic conditions. Our multigeneration study under near-natural (climatic) conditions indicates that not only the impact of climate change, but also low concentrations of pesticides may pose a reasonable risk for aquatic insects in future. The comeback of the Eurasian beaver (Castor fiber) throughout western and central Europe is considered a major conservation success. Traditionally, several subspecies are recognised by morphology and mitochondrial haplotype, each linked to a relict population. During various reintroduction programs in the 20th century, beavers from multiple source localities were released and now form viable populations. These programs differed in their reintroduction strategies, i.e., using pure subspecies vs. mixed source populations. This inhomogeneity in management actions generated ongoing debates regarding the origin of present beaver populations and appropriate management plans for the future. By sequencing of the mitochondrial control region and microsatellite genotyping of 235 beaver individuals from five selected regions in Germany, Switzerland, Luxembourg, and Belgium we show that beavers from at least four source origins currently form admixed, genetically diverse populations that spread across the study region. While regional occurrences of invasive North American beavers (n = 20) were found, all but one C. fiber bore the mitochondrial haplotype of the autochthonous western Evolutionary Significant Unit (ESU). Considering this, as well as the viability of admixed populations and the fact that the fusion of different lineages is already progressing in all studied regions, we argue that admixture between different beaver source populations should be generally accepted. A range-wide synthesis and timeline for phylogeographic events in the red fox (Vulpes vulpes) Background: Many boreo-temperate mammals have a Pleistocene fossil record throughout Eurasia and North America, but only few have a contemporary distribution that spans this large area. Examples of Holarctic-distributed carnivores are the brown bear, grey wolf, and red fox, all three ecological generalists with large dispersal capacity and a high adaptive flexibility. While the two former have been examined extensively across their ranges, no phylogeographic study of the red fox has been conducted across its entire Holarctic range. Moreover, no study included samples from central Asia, leaving a large sampling gap in the middle of the Eurasian landmass. Results: Here we provide the first mitochondrial DNA sequence data of red foxes from central Asia (Siberia), and new sequences from several European populations. In a range-wide synthesis of 729 red fox mitochondrial control region sequences, including 677 previously published and 52 newly obtained sequences, this manuscript describes the pattern and timing of major phylogeographic events in red foxes, using a Bayesian coalescence approach with multiple fossil tip and root calibration points. In a 335 bp alignment we found in total 175 unique haplotypes. All newly sequenced individuals belonged to the previously described Holarctic lineage. Our analyses confirmed the presence of three Nearctic- and two Japan-restricted lineages that were formed since the Mid/Late Pleistocene. Conclusions: The phylogeographic history of red foxes is highly similar to that previously described for grey wolves and brown bears, indicating that climatic fluctuations and habitat changes since the Pleistocene had similar effects on these highly mobile generalist species. All three species originally diversified in Eurasia and later colonized North America and Japan. North American lineages persisted through the last glacial maximum south of the ice sheets, meeting more recent colonizers from Beringia during postglacial expansion into the northern Nearctic. Both brown bears and red foxes colonized Japan's northern island Hokkaido at least three times, all lineages being most closely related to different mainland lineages. Red foxes, grey wolves, and brown bears thus represent an interesting case where species that occupy similar ecological niches also exhibit similar phylogeographic histories. Large-scale genetic census of an elusive carnivore, the European wildcat (Felis s. silvestris) The European wildcat, Felis silvestris silvestris, serves as a prominent target species for the reconnection of central European forest habitats. Monitoring of this species, however, appears difficult due to its elusive behaviour and the ease of confusion with domestic cats. Recently, evidence for multiple wildcat occurrences outside its known distribution has accumulated in several areas across Central Europe, questioning the validity of available distribution data for this species. Our aim was to assess the fine-scale distribution and genetic status of the wildcat in its central European distribution range. We compiled and analysed genetic samples from roadkills and hundreds of recent hair-trapping surveys and applied phylogenetic and genetic clustering methods to discriminate wild and domestic cats and identify population subdivision. 2220 individuals were confirmed as either wildcat (n = 1792) or domestic cat (n = 342), and the remaining 86 (3.9 %) were identified as hybrids between the two. Remarkably, genetic distinction of domestic cats, wildcats and their hybrids was only possible when taking into account the presence of two highly distinct genetic lineages of wildcats, with a suture zone in central Germany. 44 % of the individual wildcats where sampled outside the previously published distribution. Our analyses confirm a relatively continuous spatial presence of wildcats across large parts of the study area in contrast to previous analyses indicating a highly fragmented distribution. Our results suggest that wildcat conservation and management should take advantage of the higher than previously assumed dispersal potential of wildcats, which may use wildlife corridors very efficiently. Background: Understanding the processes that lead to hybridization of wolves and dogs is of scientific and management importance, particularly over large geographical scales, as wolves can disperse great distances. However, a method to efficiently detect hybrids in routine wolf monitoring is lacking. Microsatellites offer only limited resolution due to the low number of markers showing distinctive allele frequencies between wolves and dogs. Moreover, calibration across laboratories is time-consuming and costly. In this study, we selected a panel of 96 ancestry informative markers for wolves and dogs, derived from the Illumina CanineHD Whole-Genome BeadChip (174 K). We designed very short amplicons for genotyping on a microfluidic array, thus making the method suitable also for non-invasively collected samples. Results: Genotypes based on 93 SNPs from wolves sampled throughout Europe, purebred and non-pedigree dogs, and suspected hybrids showed that the new panel accurately identifies parental individuals, first-generation hybrids and first-generation backcrosses to wolves, while second- and third-generation backcrosses to wolves were identified as advanced hybrids in almost all cases. Our results support the hybrid identity of suspect individuals and the non-hybrid status of individuals regarded as wolves. We also show the adequacy of these markers to assess hybridization at a European-wide scale and the importance of including samples from reference populations. Conclusions: We showed that the proposed SNP panel is an efficient tool for detecting hybrids up to the third-generation backcrosses to wolves across Europe. Notably, the proposed genotyping method is suitable for a variety of samples, including non-invasive and museum samples, making this panel useful for wolf-dog hybrid assessments and wolf monitoring at both continental and different temporal scales. Wolves (Canis lupus) are currently showing a remarkable comeback in the highly frag-mented cultural landscapes of Germany. We here show that wolf numbers increasedexponentially between 2000 and 2015 with an annual increase of about 36%. Wedemonstrate that the first territories in each newly colonized region were establishedover long distances from the nearest known reproducing pack on active militarytraining areas (MTAs). We show that MTAs, rather than protected areas, served asstepping-stones for the recolonization of Germany facilitating subsequent spreadingof wolf territories in the surrounding landscape. We did not find any significant differ-ence between MTAs and protected areas with regard to habitat. One possible reasonfor the importance of MTAs may be their lower anthropogenic mortality rates com-pared to protected and other areas. To our knowledge, this is the first documented casewhere MTAs facilitate the recolonization of an endangered species across large areas. Freshwater biodiversity has declined dramatically in Europe in recent decades. Because of massive habitat pollution and morphological degradation of water bodies, many once widespread species persist in small fractions of their original range. These range contractions are generally believed to be accompanied by loss of intraspecific genetic diversity, due to the reduction of effective population sizes and the extinction of regional genetic lineages. We aimed to assess the loss of genetic diversity and its significance for future potential reintroduction of the long-tailed mayfly Palingenia longicauda (Olivier), which experienced approximately 98% range loss during the past century. Analysis of 936 bp of mitochondrial DNA of 245 extant specimens across the current range revealed a surprisingly large number of haplotypes (87), and a high level of haplotype diversity (Hd = 0.875). In contrast, historic specimens (6) from the lost range (Rhine catchment) were not differentiated from the extant Rába population (F ST = 0.02, p = 0.61), despite considerable geographic distance separating the two rivers. These observations can be explained by an overlap of the current with the historic (Pleistocene) refugia of the species. Most likely, the massive recent range loss mainly affected the range which was occupied by rapid post-glacial dispersal. We conclude that massive range losses do not necessarily coincide with genetic impoverishment and that a species' history must be considered when estimating loss of genetic diversity. The assessment of spatial genetic structures and prior phylogeographic information seems essential to conserve once widespread species. The recent recolonisation of the Central European lowland (CEL) by the grey wolf (Canis lupus) provides an excellent opportunity to study the effect of founder events on endoparasite diversity. Which role do prey and predator populations play in the re-establishment of endoparasite life cycles? Which intrinsic and extrinsic factors control individual endoparasite diversity in an expanding host population? In 53 individually known CEL wolves sampled in Germany, we revealed a community of four cestode, eight nematode, one trematode and 12 potential Sarcocystis species through molecular genetic techniques. Infections with zoonotic Echinococcus multilocularis, Trichinella britovi and T. spiralis occurred as single cases. Per capita endoparasite species richness and diversity significantly increased with population size and changed with age, whereas sex, microsatellite heterozygosity, and geographic origin had no effect. Tapeworm abundance (Taenia spp.) was significantly higher in immigrants than natives. Metacestode prevalence was slightly higher in ungulates from wolf territories than from control areas elsewhere. Even though alternative canid definitive hosts might also play a role within the investigated parasite life cycles, our findings indicate that (1) immigrated wolves increase parasite diversity in German packs, and (2) prevalence of wolf-associated parasites had declined during wolf absence and has now risen during recolonisation.
Continuous learning and up-skilling are paramount today. Traditional certificates often fall short in capturing the true essence of an individual's skills and abilities. While certificates celebrate the successful completion of a course or programme, they often fail to reflect the practical skills acquired through learning and experience. At VerifyEd, we believe that digital credentials hold the key to unlocking the potential of individuals by accurately surfacing and verifying their skills. Introducing VerifyEd: Recognising Skills, Empowering Individuals What is VerifyEd? VerifyEd is a pioneering platform that issues digital credentials to recognise learning and training done in both educational institutions and workplaces. Our mission is to shift the focus from the end award to the actual skills acquired throughout the learning journey. The Challenge: Articulating Skills in a Competitive Landscape Many individuals; students, graduates, employees (in particular early career individuals) struggle to articulate the skills they have gained despite knowing the courses and training they have undergone. This lack of ability to communicate their skills effectively can hinder their career prospects and opportunities. Our Solution: Surfacing Skills, Not Just Certificates Rather than waiting for the completion of a course or award, VerifyEd encourages its partners to recognise and verify the skills gained from individual units of study and training, extracurricular activities, work experience, and other non-traditional learning avenues. By focusing on surfacing the actual skills acquired, we empower individuals to understand and communicate their capabilities more effectively. Embedded Skills: A Credible Reflection of Individual Capabilities All the credentials issued by VerifyEd have the option for course providers to embed the skills gained by individuals. This unique feature ensures the authenticity and credibility of the skills reflected in the credentials. By having verifiable evidence of their practical skills, individuals can confidently present themselves as competent candidates to potential employers. The Benefits: Empowering Individuals and Enlightening Employers Enhanced Self-Awareness VerifyEd's approach helps individuals become more aware of the skills they possess, allowing them to articulate their capabilities confidently. By having a tangible and verified record of their skills, individuals can present themselves as competent employees within the workplace and candidates in the job market. Transparent Evaluation for Employers VerifyEd enables employers to transparently evaluate the skills possessed by potential candidates. Access to verified skills profiles empowers employers to make accurate and informed hiring decisions, ensuring the right skills match for their organisations. VerifyEd not only benefits employers in evaluating the skills of potential candidates but also provides valuable insights into the skills of their existing employees. By utilising verified skills profiles, employers can gain a comprehensive understanding of the skills their employees possess and how they align with the needs of their organisation. This empowers employers to make informed decisions regarding talent management, career development, and internal mobility. By accessing the verified skills profiles of their employees, employers can: - Identify Skill Gaps: By comparing the skills required for specific roles or projects with the skills possessed by their employees, employers can identify any gaps that may exist. This allows them to devise targeted training programs or initiatives to bridge those gaps, ensuring their workforce remains skilled and competitive. - Facilitate Internal Mobility: Having a clear picture of the skills their employees possess enables employers to identify suitable candidates for internal job openings or promotions. This internal mobility not only helps in retaining top talent but also fosters a culture of growth and career progression within the organisation. - Enable Effective Skill Utilisation: Understanding the skills of employees allows employers to assign tasks and projects more effectively. They can match individuals with the right skills to specific projects, leading to enhanced productivity and better outcomes. This targeted allocation of resources ensures that each employee's skills are utilised optimally, benefiting both the individual and the organisation. - Support Succession Planning: Succession planning is critical for organisations to ensure a smooth transition when key positions become vacant. By analysing the skills profiles of employees, employers can identify potential successors for key roles and implement development plans to groom them for future leadership positions. This proactive approach mitigates the risks associated with leadership gaps and ensures continuity. - Foster a Learning Culture: Transparently showcasing employee skills through digital credentials can inspire a culture of continuous learning and skill development within the organisation. When employees see their skills recognised and valued, they are motivated to further enhance their capabilities, leading to a more skilled and adaptable workforce. By utilising VerifyEd's digital credentials and verified skills profiles, employers can gain deep insights into the skills of their employees. This empowers them to make data-driven decisions, promote talent development, and create a work environment that nurtures the growth and potential of their workforce. Uptake and Momentum: Leading the Skills-Based Hiring Revolution In the past month, VerifyEd has witnessed a remarkable surge in the number of verified skills issued on the platform. In June 2023 alone, over 6,500 skills were proudly verified. This substantial uptake reflects the growing trend towards skills-based hiring, which is deemed as the future of recruitment. VerifyEd plays a pivotal role in this paradigm shift by providing verified skills profiles that are free from embellishment and self-proclaimed titles. A Vision for the Future: Tailored Learning and Employment Pathways VerifyEd's ultimate goal is to create tailored learning and employment pathways based on verified skills. By analysing individuals' current skills, understanding their career aspirations, and studying the skills demanded by various job postings, VerifyEd aims to bridge the gap between individuals and employers. Through comprehensive skills gap analysis, bespoke learning and employment pathways will be developed to equip individuals with the necessary competencies to progress in their careers. This approach also enables employers to identify internal talent for up-skilling to fill any skills gaps within their organisations. VerifyEd is committed to redefining the recognition and valuation of skills. By harnessing the power of digital credentials, VerifyEd recognises and empowers individuals, ensuring their talents are nurtured and their opportunities are abundant.
Searching for answers to the big questions of life Ecclesiastes 1: These are the words of the Quester, David's son and king in Jerusalem. The Greek word "Ecclesiastes" is generally translated "the Preacher" or "the Teacher." The name of this book of the Bible is taken from the opening words in which the writer, Solomon, gives himself that title. The book is about Solomon's quest for meaning, how he tries many of the things people still try today, and how he concludes that none of them live up to their promise. In The Message, Peterson picks up on the "quest" of Solomon and calls him, "the Quester" rather than "the Preacher." In other words, the emphasis is on the search for meaning, happiness, and satisfaction rather than on the proclamation of the result of that search. Solomon wants more than power, wealth, fame, peace, and success. Having tried them all, he's convinced that they're not all they're cracked up to be. Actually, Ecclesiastes doesn't try very hard to give us "the answer" but it does a good job of asking "the question" concerning the search for answers to the big questions of life. Take Away: Like the writer of Ecclesiastes people today still search for meaning. Tag: satisfaction Devotional on Proverbs Learning humility Proverbs 15: First you learn humility, then you experience glory. Humility has to be learned because we're all born thinking the world revolves around us. Unless I learn humility I spend my life, not necessarily thinking I'm better than others, but thinking that everything that happens should happen the way I want it to. For me to be humble is for me to realize that I'm not the center of the universe and that the world has no obligation to please me. Beyond that, to be humble is for me to come to the realization the most satisfying life is not all about my getting my own way about things, but is, instead, found as I live with others in mind. Jesus said that I'm to "love my neighbor as myself." The result of such a life, according to the wise man of the Proverbs, is "glory." That is, others will be irresistibly drawn to me and my life will influence them in positive ways. Not only that, but God will be pleased with me for patterning my life after that of his own Son who humbly lived and died for others. This proverb reminds me that the route to glory isn't by my taking power and trying to shape the world to suit me. Instead, it's achieved by loving others and placing their needs at a level equal to my own. Take Away: Contrary to what we may think, humble people are some of the most influential people there are. Devotional on Isaiah The real thing Isaiah 55: Hey there! All who are thirsty, come to the water! I like to drink my share of coffee and enjoy a diet Dr. Pepper once in a while. But when I'm really thirsty, I reach for a glass of water. Nothing quenches my thirst like a glass of cool, sparkling water. Spiritually speaking, there's thirst-quenching water. I can turn to a million substitutes that promise satisfaction, but they'll all let me down. For some reason, though, I tend to turn to almost anything but the Real Thing. No, I'm not talking about Coca-Cola! Into the market place of life Isaiah comes, shouting out his message of hope to those who've tried everything else yet are still dissatisfied with life. His message reminds us that there's a genuine Source of satisfaction. That Source isn't a "thing." Rather, it's a "Person." Are you thirsty? Come to the water. His name is Jesus. Take Away: Only Jesus, the "living water," satisfies the soul. Devotional on Amos God Hunger Amos 8: They'll go anywhere, listen to anyone, hoping to hear God's Word. God warns that a famine is coming to the nation of Israel. This time, it won't be a famine of food or water, but a famine of God's Word. Now, Amos isn't talking about a lack of leather bound Bibles. He's talking about a time when God, Himself, goes silent. When that happens, the prophet says, people will roam the land seeking a message from the Lord. Amos ties this to the Judgment, a time when the God who has been available to them, reaching out to them, calling them to return withdraws the invitation. Many have abused the prophets, even murdering them in an attempt to silence their voices. Now, one of those prophets warns that they're going to get their wish and that they won't like it when they do. I'm reminded today that there's a measure of God-hunger in every human being. There are times when people long for the touch of God on their lives. In their ignorance, they'll substitute something else but whatever it is will fail to satisfy. Realistically, why settle for a poor substitute when the Real Thing is available? Happily, we aren't living in the day Amos describes. Right this moment God is speaking, reaching out to all who'll come. This isn't an invitation to join a church. Rather, it's an invitation to respond to the call of God to fellowship with him. Take Away: Right this moment the Lord is speaking, reaching out to all who'll come. Devotional on Haggai The secret to satisfaction Haggai 1: Take a good, hard look at your life. The work of the Temple was put on hold years earlier because people felt they needed to concentrate on the necessities of life. They built homes and cleared land for planting crops. They built walls to protect them in what had become a dangerous land. Meanwhile, the Temple was left in ruins. Now, as they face a devastating drought, God's man tells them it's time to take a hard look at their lives. All their building and planting is meaningless without God. Even with plates full of food and warm clothing to wear they've faced an inner dissatisfaction with life. Their neglect of the Temple is a symptom of something even more important. Beyond the building, they've left the God of the building out on the periphery of their lives. Without him life is empty and meaningless. Their mistake is both colossal and common. The worship of God is not a luxury to be put on hold till "important" things are cared for. In fact, worship is a core necessity and without God, nothing ever satisfies. We can't be too hard on the people of Haggai's day because we too tend to view worship as something that can be pushed aside as we pursue things we deem to be more important. The issue isn't that God's unhappy with us and will find a way to get back at us for ignoring him. Instead, it's that when we leave God out, we're ignoring the central need of our lives. In the case before us, that's evidenced by their failure to rebuild the Temple. In our case, it might be that we don't show a proper interest in the worship of God. When we fail here, we find that all other successes in life taste like failures. When we succeed here, we find that everything else in life finds its proper place. Take Away: Without the Lord life is empty and meaningless. Devotional on Haggai The correct focus in worship Haggai 1: The little you have brought…I've blown away. The people being addressed in Haggai's short story aren't pagans who have turned their backs on God to worship another. They aren't godless people at all. Despite their having ruins instead of a Temple they have worship services. As faithful Jews they bring sacrifices and observe the feasts and regulations of their religion. Yet, somehow, their worship experience is dissatisfying to them. As they leave these events they feel they've been faithful in keeping all that which is required of them but they remain empty inside. Haggai puts his finger on the problem. In reframing their religion to suit themselves they've blundered into a religion that the God they worship rejects. Failure to rebuild the Temple is the symptom of this larger problem. This situation speaks to me today and its tone isn't soothing! How much of my religious life is founded on obligation and tradition and how much of it is about a living, vital relationship with God? While I'm busy being sure all the details of worship are taken care of have I forgotten that it isn't me who's in charge? What makes me think God will accept a self-centered worship effort from me in the first place? The thing is that as I picture the people of Haggai's day walking out of a worship service feeling that somehow something is missing, I can identify with them. That, my friends, makes me very uncomfortable. Take Away: Our religious lives are to be founded on a living, vital relationship with God. Devotional on Haggai Listening and honoring Haggai 1: In listening to Haggai, they honored God. The drought has everyone worried. If rain doesn't come soon the resulting famine will bring misery and death. Not only that, but there's a general dissatisfaction among the returned exiles. Even when they do things that ought to satisfy they're left feeling empty. Then Haggai brings his sermon. He says that the reason for no rain is that God's getting their attention. They're living self-centered lives and have failed to honor him by rebuilding the Temple. He also says that the reason for their general dissatisfaction is that they've been looking for satisfaction in the wrong things. Only the Lord can satisfy their lives and they can experience him only by putting him first. At this point the people stand where their ancestors stood many times through the years. Will they listen to the message from God or will they harden their hearts and become more entrenched than ever in their refusal to honor him? Their answer is a resounding decision to obey the voice of the Lord. Where their ancestors failed they succeed. This watershed moment is rewarded with a further message from the Lord who declares, "I am with you!" I love what happens here. As I've read through the Prophets I've encountered one instance of rebellion after another. How refreshing it is to hear God's prophet declare God's message to God's people and see them listen and obey. It's almost as though the sun breaks through the clouds to shine down on the words I'm reading. The people of Haggai's day messed up, but when God got their attention and declared his intentions they responded in humble obedience. Personally, I'd rather not mess up in the first place but when I do, I want their "listening and honoring" to be my inspiration. Take Away: Better to do it the Lord's way all along, but if not, it's good to at least humbly accept his correction and move forward from there.
What are the TEAS Test biology questions? Whether we have the capacity to answer these questions or whether we do not is a simple matter of the way that things are going. If you are looking for a good answer to many TEAS research questions, you will need to use the Science Search Strategies Search platform. So here are some other questions I think you can take up to a better position: Which of the above search methods are free tools when playing in the science-based format? Could we use a non-search format as well? What they offer does not use search, but it's still not great, is having the opportunity to explore a wide area of research, so that you can take advantage of it. What is the status of the content on MomsWatch? According to the MomsWatch-Initiated Content Visualization Project they offer a 'content visualization' tool, perhaps useful to you as a scientist. However, going by the Mancei-Dorem's Law, Search will not help you put your data into a new science format altogether. MomsWatch can only do this if you have a important link visualization project with science and engineering content, that could be used by any scientist or engineering lab. Therefore, you can do searching in the text of a text box, either using traditional search engines like Wikipedia or Google, as always. You have to use these tools, as they are quite complex and they are only for the science-based search space. As with most search engines, no amount of hard coding tools is going to help you stand out.What are the TEAS Test biology questions? What are the TEAS DRAGONS test questions? The TEAS ARE there questions?The question has been placed into the answers! Would you be interested in a TEAS A Game? What other games would you play? Which would be valuable to you? Do they consist of different types of gameplay? Are they game dependent? Or are they simple to understand? How does the answer of any of these questions relate to your game and what is the answer of a different game? Maybe the answer of a single game would be fine, but it would be difficult to have a different answer for multiple games. Maybe it would be simpler to answer some better questions, in a more abstract way? Who just answered the question, did whatever else went to head and would you still understand it? Can you think of a good way to imagine a game as it is but who is doing everything that you do right? Perhaps it would be better to be as an individual to do what goes on your side, i.e. play whatever you want while filling out the question and being taken care of Question: Would completing a single-player game work for you as in the example presented here? Will the answers contain 1/16 = 15, 5/16 = 16 or would you get a score of 14 because that was the answer you got for the previous game? Answer:I have a singleplayer game and I don't know how that would be understood by the game, even though I do play games on those board. I have another game which is more fun to use but I cannot give a text answer and this one works too against me. Click On Where You Are Looking The Game Is The Game Is To Complete If you have a question about how to take a single player game and how to complete it, ask on the first page of this page. To pick the answer or not choose a game based onWhat are the TEAS Test biology questions? Have you ever read the Natural History course on Pigeon Hake's book? And by some estimates, one or two years could take you 40 minutes of play with an enormous bag of food! As a first visit has begun, you'll have to go down and collect a bottle, fill it with water and drop the contents on the floor. The next task is, if you don't know what to expect, that is – simply pick up your candy bar, fill it with coffee beans (or anything that cooks) and buy it out of the store for a refund. After you take this task, if you can really come in handy they'll have ready-made candy to hand! (There's space in the box for a whole bag of candy with a rubber lining and you may wish to tie a candle for convenience only – although you can wear really small bags of ryegourat, which is pretty convenient!) Now, if you have a gift and only need a few small tools, that is, an item that glides over your bowl, you could do a mini-gifting in your pocket (with a tiny pinch of glue) and that might be what you've been looking for. ## GIVEAWAY These days, there are no more fun aspects of gardening as they fall under modern housekeeping. It's highly predictable after twenty years, but that's the reality. Take My Online Class Reviews Most gardeners know that there are no shortcuts to the things you have: sunblock and corrugated walls, brush, bedswiping, tree threshing. They know that to be part of growing and not doing more. It doesn't matter if you live in a basement or a garage or an office, there's plenty of cover and a very good supply. There certainly are outdoor supplies. There's always plenty of mulch and other equipment. There's not actually much to buy the products you are going to need that you could even
In which country per capita income is highest? GDP per Capita # \| Country \| GDP (nominal) per capita (2017) \| 1 \| Qatar \| $61,264 \| 2 \| Macao \| $80,890 \| 3 \| Luxembourg \| $105,280 \| 4 \| Singapore \| $56,746 \| What is top 10 percent wealth in us? Personal Net Financial Assets….So let's talk about what we mean by 'top 10%' or 'access to wealth' - Your family's net wealth is $1 million or more. - Your parent's annual income is in the top 90th percentile for your state. - You or your family members have a family foundation. Why does Russia have a high GDP per capita? Russia's wealth Russia generates most of its wealth through its energy sector, given that a large percentage of its industrial and agricultural sectors have been privatized in the 1990s. The majority of. How much wealth does the top 10 percent have? According to the first quarter of 2021, the top 10 percent held 70 percent. A total of 8 percent of the U.S. Net worth is the value of all assets held by a person minus all liabilities. In fact, 32 percent of that wealth went to the top 1%. What are high income countries Class 10? Countries with per capita income of US$ 49,300 per annum and above in 2019, are called high income or rich countries and those with per capita income of US$ 2500 or less are called low-income countries. What is the 1% in USA? In the USA, a family must earn an income of $597,815 to be in the top 1% of earners, according to a study by Smart Asset. But the income and rankings vary per state. In Connecticut, a family needs almost $900,000 to be in the top 1%, while in West Virginia a family needs $350,000. Is Russia richer than UK? Russia has a GDP per capita of $27,900 as of 2017, while in United Kingdom, the GDP per capita is $44,300 as of 2017. Is Canada a rich country? Canada is a wealthy nation because it has a strong and diversified economy. A large part of its economy depends on the mining of natural resources, such as gold, zinc, copper, and nickel, which are used extensively around the world. Canada is also a large player in the oil business with many large oil companies. What is the richest 10 percent in UK? Percentile point \| Wealth to qualify \| Percentage of total wealth owned by people at and above this level \| Top 1% \| £688,228 \| 21% of total UK wealth \| 2% \| £460,179 \| 28% of total UK wealth \| 5% \| £270,164 \| 40% of total UK wealth \| 10% \| £176,221 \| 53% of total UK wealth \|
The meaning of ALPHABET is a set of letters or other characters with which one or more languages are written especially if arranged in a customary order. How to use the alphabet in a sentence. An alphabet is a standardized collection of basic written symbols or graphemes (referred to as letters) that represent the phonemes of various spoken languages. Not all writing systems represent language in this way; in a syllabary, for example, each character represents a syllable, and in logographic systems, characters represent words, morphemes, or other semantic units. The Proto-Canaanite script, later known as the Phoenician alphabet, is regarded as the first alphabet and is thought to be the ancestor of most modern alphabets, including Arabic, Cyrillic, Greek, Hebrew, Latin, and possibly Brahmic. It was created (as the Proto-Sinaitic script) by Semitic-speaking workers and slaves in the Sinai Peninsula by selecting a small number of hieroglyphs commonly seen in their Egyptian surroundings to describe the sounds, rather than the semantic values, of their own Canaanite language. The English word alphabet was derived from the Late Latin word alphabetic, which was derived from the Greek o (alphabets). The Greek word was formed by combining the first two letters, alpha and beta. The Greek letters were named after the first two letters of the Phoenician alphabet, aleph (which also meant ox) and bet (which also meant house). An alphabet's number of letters can be quite small. At one point, the Book Pahlavi script, an abjad, had only twelve letters and may have had even fewer later on. The Rotulas alphabet now only has twelve letters. Although the Hawaiian alphabet is sometimes said to be small, it actually consists of 18 letters, including the okina and five long vowels. Hawaiian Braille, on the other hand, only has 13 letters. Alphabets are typically associated with a standard letter ordering. This makes them useful for collation purposes, as it allows words to be sorted alphabetically. It also means that their letters can be used to "number" ordered items in contexts such as numbered lists and number placements.
The Reading Boys Club Year 12 Sociologists are being encouraged to engage with a wider range of academic reading to support their learning. We are currently running a pilot scheme for 9 Year 12 boys, The Reading Boys Club, with a view to teaching the habit of reading. This is running across 2 study periods a fortnight where students are reading a range of texts from 'Prisoners of Geography' to 'The Tattooist of Auschwitz'. Students will be assessing their reading speeds and reflecting on the benefit of 2 hours away from phones and other distractions. Male staff are also in support, role modelling reading as not just a female hobby. We hope this will provide students with an alternative option to social media and open their minds to the benefit of reading across all of their studies.
Social media has developed into an essential tool for Gen Z to emotionally express themselves, going beyond just a place to share pictures and stay in touch with friends. Gen Z, or Generation Z, is defined as those born between the middle of the 1990s and the beginning of the 2010s. They are known for their deep connection with technology and their natural ability to move between different online platforms with ease. However, beyond its surface appeal, social media serves as a dynamic emotional outlet for this generation, allowing them to share, connect, and seek support in unprecedented ways. The Evolution of Social Media Before delving into how Gen Z utilizes social media as an emotional outlet, it's crucial to understand the evolution of these platforms. While Facebook was the pioneer in social networking, platforms like Instagram, Snapchat, TikTok, and Twitter have emerged as Gen Z's preferred spaces for self-expression. Each platform offers unique features catering to different emotional needs, ranging from visual storytelling to ephemeral messaging and short-form videos. Authenticity and Vulnerability One of the defining characteristics of Gen Z's approach to social media is their demand for authenticity. Unlike previous generations, who often curated their online personas meticulously, Gen Z values vulnerability and raw authenticity. They use platforms like Instagram and TikTok to share unfiltered moments from their lives, including struggles, triumphs, and moments of vulnerability. By doing so, they foster a sense of connection and relatability with their peers, creating a virtual support network where authenticity reigns supreme. Community and Support Social media serves as a virtual community where Gen Z can seek support and empathy from like-minded individuals. Whether it's discussing mental health challenges on Twitter, sharing personal stories on Instagram, or seeking advice on Reddit forums, Gen Z leverages social media to connect with others who understand their experiences. This sense of community fosters a supportive environment where individuals feel validated, understood, and less alone in their struggles. Creative Expression Social media serves as a creative outlet for communication for Generation Z. On platforms like TikTok and Instagram, reels allow users to showcase their talents, share their passions, and express themselves creatively through short-form videos. Whether it's lip-syncing to popular songs, showcasing DIY projects, or sharing art and poetry, Gen Z uses social media as a medium to unleash their creativity and connect with others who appreciate their unique talents. Emotional Regulation In a world where stress and anxiety are prevalent among young people, social media serves as a tool for emotional regulation for Gen Z. Whether they're feeling overwhelmed, stressed, or anxious, scrolling through comforting memes on Instagram or watching funny videos on TikTok can provide a much-needed distraction and temporary relief. Additionally, sharing their own thoughts and feelings on social media allows Gen Z to process their emotions and obtain insight and assistance from their virtual community. Activism and Social Change Gen Z is known for their passion for social justice and activism, and social media serves as a powerful platform for amplifying their voices and driving meaningful change. Whether it's raising awareness about climate change, advocating for LGBTQ+ rights, or mobilizing for political action, Gen Z utilizes platforms like Twitter, Instagram, and TikTok to organize protests, share resources, and spark important conversations. Social media enables them to connect with like-minded individuals globally, creating a sense of solidarity and collective action in the fight for social justice. Challenges and Risks Although social media provides Gen Z with a lot of emotional release, there are risks and obstacles associated with it as well. Low self-esteem, comparison anxiety, and feelings of inadequacy can result from the constant pressure to project a flawless online persona. Moreover, cyberbullying and online harassment are prevalent issues that can have detrimental effects on Gen Z's mental health and well-being. It's essential for parents, educators, and policymakers to address these challenges proactively and foster a safe and supportive online environment for young people. Social media plays a multifaceted role as an emotional outlet for Gen Z, offering a platform for authentic self-expression, community building, creative exploration, emotional regulation, activism, and social change. Gen Z is changing how we connect, communicate, and support one another in the digital age by utilizing social media. But it's important to talk about the difficulties and dangers that come with using social media and to make sure that young people have the tools and skills they need to use these sites sensibly and safely. Gen Z's relationship with social media will change as it develops, influencing how future generations will communicate digitally and express their emotions.
This page presents current and completed doctoral projects that are being or have been carried out with the participation of the Chair of Digital Humanities. Current dissertation projects Ariadne Baresch: La Recherche selon Albertin Simonet : réécriture d'un temps fugitif Marcel Proust's novel cycle À la Recherche du temps perdu (1913-1927) is primarily known for its themes of memory and time, as well as the Madeleine scene, which acts as an emblematic nexus between these two subjects. The complexity that constitutes the oeuvre and its readings is reflected in the countless studies that have dealt with the "étoffe proustienne" over the course of a century. The plot, which is told from the perspective of a first-person narrator, highlights one character in particular despite its thematic variety: his lover Albertine Simonet. As the most frequently mentioned character in the novel, her enigmatically drawn personality and her supposed leisure activities are the driving force behind the narrator's constant reflections, which are characterized by jealousy. The deliberately ambivalent portrayals thus prove to be stimuli for various levels of analysis and possible interpretations. In the artistic field, this is reflected in numerous adaptations of various media genres. The aim of the doctoral project is to comparatively explore Proust adaptations that have not yet received sufficient attention. Genetic, intermedial and thematological comparisons will be tested in order to encompass both the heterogeneity of a multimedia and multilingual corpus and the plurality of the Albertine character. Supervisors: Prof. Dr. Christof Schöch (Trier), Professeur Henri Garric (Dijon). Julia Röttgermann: Affekt und Aufklärung - Automatische Erhebung literaturhistorisch relevanter Informationen aus Volltexten am Beispiel von französischen Romanen des XVIII. Jahrhunderts The dissertation, which is part of the Mining and Modeling Text (MiMoText) research project, deals with a corpus of French novels from the period 1750-1800, which are being translated into TEI-compliant XML for the first time and published as part of the European Literary Text Collection (ELTeC). Quantitative and qualitative methods of text analysis are applied to the corpus with the aim of extracting information on aspects such as themes, characters, places or motifs that can be used in literary studies. In-depth analyses and evaluations are planned on the topic of affects in the French novel of the 18th century. All extracted data will be modeled as linked open data in a semantic network, linked with further information from MiMoText and will be available for structured queries. Supervisors: Prof. Dr. Christof Schöch (Trier), Prof. Dr. Matei Chihaia (Wuppertal). Andreas Büttner: Bilingual Stylometry: A Computational Study of the Arabic-Latin Textual Tradition The late medieval translation of scientific and philosophical texts from Arabic into Latin heavily influenced the history of European thought for many centuries. This transmission of knowledge was mediated by translators, many of whom remained anonymous, while others, e.g. Gerhard of Cremona or Dominicus Gundissalinus, are appreciated as important historical figures. The ongoing digitisation of the texts facilitates innovative ways of analysis, leading to new insights into their work. The first part of the dissertation will deal with the digitisation methods employed in building the bilingual corpus. A special focus will be placed on the problem of the alignment of the Arabic original and the Latin translation. I will evaluate existing methods, develop new technologies building on neural machine translation, and compare them with more traditional approaches, using the Arabic and Latin translations corpus and, for comparison, text collections in other languages. The main part will be devoted to the problem of translator identification using stylometric methods. To compensate for the often very short tractates and large range of subject matters of the texts, I will employ the information gained from the bilingual alignment to filter the stylistic signature of the translator from the statistical properties of language-use in the corpus. The philological aim of the dissertation therefore is to gain new perspectives on the history of the Arabic-Latin translation movement. From the methodological point of view, the work will seek new strategies to analyse bilingual corpora, especially concerning techniques of stylometry. Supervisors: Prof. Dr. Dag Nikolaus Hasse (Erstbetreuer, Würzburg), Prof. Dr. Fotis Jannidis (Würzburg), Prof. Dr. Christof Schöch (Trier) Completed dissertation projects Keli Du: Evaluation von Topic Modeling in Digital Humanities (2023) Topic modeling is an approach for semantic indexing of texts. The groups of semantically related words (topics) in a corpus can be extracted using topic modeling. The topics represent an overview of the possible topics in the corpus. Topic modeling has been used more and more in digital humanities in recent years, while the technical side of topic modeling has been less presented and discussed in research reports compared to the analysis and interpretation of the topics and the model. The outcome of topic modeling can be influenced by many technical factors. But there is still no common understanding in Digital Humanities on how to deal with these factors in order to use topic modeling in an optimal way. For this reason, my dissertation aims to better understand the relationships between the factors and the quality of the topic model as well as the quality of the topics through systematic investigations. Supervisors: Prof. Dr. Fotis Jannidis (Würzburg), Prof. Dr. Christof Schöch (Trier), Prof. Dr. Andreas Hotho (Würzburg). Dr. Keli Du is now a researcher at the Trier Center for Digital Humanities. Tilman Schalmey: Computerlinguistische Datierung schriftsprachlicher chinesischer Texte (2022) From the introduction: "Over the past centuries, the dating of texts has occupied researchers from various disciplines and cultural complexes. The focus is often on exegesis and authenticity research. Linguistic text dating is generally based on the observation of and prior knowledge about language change, traditionally through the observation of certain - individual - linguistic phenomena, words, word forms, signs or grammatical structures. Above all, the vocabulary of any actively used language, whether written or colloquial, is constantly changing. New words are added, while others gradually fall out of use. [...] The aim of this work is to enable the content-based chronological classification and dating of written Chinese texts using computational linguistic methods. For this purpose, [statistical] language models are to be adapted and applied to Chinese text material for the first time." Supervisors: Prof. Dr. Christian Soffel (Erstbetreuer), Prof. Dr. Christof Schöch (Zweitbetreuer) Ulrike Henny-Krahmer: Genre Analysis and Corpus Design: 19th Century Spanish American Novels, 1830-1910 (2021) This dissertation in the field of Digital Literary Stylistics is concerned with theoretical concerns of literary genre, with the design of a corpus of 19th-century Spanish American novels, and with its empirical analysis in terms of subgenres of the novel. The digital text corpus consists of 256 Argentine, Cuban, and Mexican novels from the period between 1830 and 1910. It has been created with the goal to analyze thematic subgenres and literary currents that were represented in numerous novels in the 19th century by means of computational text categorization methods. The texts have been gathered from different sources, encoded in the standard of the Text Encoding Initiative (TEI), and enriched with detailed bibliographic and subgenre-related metadata, as well as with structural information. To categorize the texts, statistical classification and a family resemblance analysis relying on network analysis are used with the aim to examine how the subgenres, which are understood as communicative, conventional phenomena, can be captured on the stylistic, textual level of the novels that participate in them. The result is that both thematic subgenres and literary currents are textually coherent to degrees of 70-90 %, depending on the individual subgenre constellation. Besides the empirical focus, the dissertation also aims to relate literary theoretical genre concepts to the ones used in Digital Genre Stylistics as a subfield of Digital Humanities. It is argued that literary text types, conventional literary genres, and textual literary genres should be distinguished on a theoretical level to improve the conceptualization of genre for digital text analysis. Supervisors: Prof. Dr. Christof Schöch (Univ. Trier), Prof. Dr. Fotis Jannidis (Würzburg), Prof. Dr. Hanno Ehrlicher (Tübingen) JProf. Dr. Ulrike Henny-Krahmer is now a Junior Professor at Rostock University. Ekaterina Kamlovskaya: Computer-assisted analysis of postcolonial features in the key discourses of a corpus of Australian Indigenous life writing (2021) Supervisors: Prof. Dr. Christoph Schommer (Univ. Luxembourg), Prof. Dr. Nina Tahmasebi (external supervisor, Univ. of Gothenburg). Prof. Dr. Christof Schöch (external supervisor, Univ. Trier). José Calvo Tello: The Novel in the Spanish Silver Age: A Digital Analysis of Genre through Machine Learning (2020) Between the end of the 19th century and the end of the Spanish Civil War in 1939, the so-called Silver Age (Edad de Plata) emerged in Spanish art. An aesthetic generational change took place in the literature of this era: Many of the representational devices of the realistic and naturalistic novel were abandoned and new forms of expression were discovered. The works in question are classified and described by literary historians in a highly controversial manner. The subject of this study are the works described by literary history as literary prose texts written in Spain by Spanish authors and published between 1880 and 1939. In total, the collection of texts includes around 200 works. The aim of the study is therefore to use computer-aided methods to answer the following questions: How did the subgenres of the Spanish novel and shorter narrative prose develop between 1880 and 1939? Which stylistic features and which linguistic levels (morphology, syntax, lexis, semantics or text) prove useful for the study of the literary prose genres of this period? Supervisors: Prof. Dr. Christof Schöch, Prof. Dr. Fotis Jannidis (Würzburg), Prof. Dr. Angela Schrott (Kassel) See the monograph: José Calvo Tello, The Novel in the Spanish Silver Age. A Digital Analysis of Genre Using Machine Learning (Bielefeld: Bielefeld University Press / transcript, 2021). Dr. Calvo Tello is now a subject librarian for Digital Humanities and Romance Studies at the State and University Library Göttingen. Matthias Bremm: Teil-überwachtes und aktives Lernen mit unterschiedlichen annotierenden Personen zur Informationsextraktion in Texten (2020) Located in the field of information extraction, this work combines several methods from the field of machine learning. It presents a new algorithm that combines semi-supervised learning with active learning. The starting point is the analysis of the data by dividing it into several views. Here, the input from different people is divided. In each case, the algorithm uses classifiers to generate separate models that are built from the individual labels of the people. Crowdsourcing is used to obtain the required amount of data, which makes it possible to reach a large number of people. The people are given the task of annotating texts. On the one hand, this is initially done for a historical text corpus. The steps required to offer and carry out the annotation task in crowdsourcing portals are listed. On the other hand, a current data set of short messages is used. The algorithm is applied to these sample data sets. Experiments are conducted to determine the optimal parameter selection. In addition, the results are compared with the results of previous algorithms. Supervisors: Prof. Dr. Reinhard Köhler (main supervisor), Prof. Dr. Carolin Sporleder (until 2019), Prof. Dr. Christof Schöch (from 2019). Dr. Bremm is a researcher at the Trier Center for Digital Humanities. Winfried Höhn: Semiautomatische Annotation von Orten in digitalisierten Altkarten (2018) Supervisors: Prof. Dr. Christoph Schommer (main supervisor, Univ. Luxembourg). Prof. Dr. Christof Schöch (Dissertation Defence Committee Member), Prof. Dr. Andreas Fickers (Dissertation Defence Committee Member).
For people with an anxiety disorder, whether diagnosed or undiagnosed, it is common to try to reduce that anxiety with a drink. After all, alcohol is a sedative and can take the edge off severe anxiety in certain cases. At least, at first. In fact, alcohol misuse can worsen anxiety in the long run. Someone who routinely uses alcohol to self-medicate anxiety may end up with co-occurring disorders—addiction to alcohol and anxiety. If you or someone you care about is struggling with anxiety as well as a potential alcohol use disorder, the best option is a dual diagnosis treatment program that can address both disorders at once. Reach out to The Right Step Houston to learn more about how alcohol and anxiety interact in your brain and what the treatment options are when these disorders are co-occurring. Simply fill out this form or dial 1.844.768.0169 to connect with one of our staff. Understanding Alcohol and Anxiety Having a stressful day is different from having an anxiety disorder. In our culture, having a drink at the end of a difficult day or week is considered a completely normal way to unwind. However, chronic anxiety that can seem to come out of nowhere may be a symptom of an anxiety disorder. If you have anxiety, you can feel it at any time, but it is also likely to be triggered by everyday stress and certainly extraordinary stress. Using alcohol to treat anxiety symptoms on a regular basis can make things worse, however. Some effects of chronic use of alcohol to medicate anxiety symptoms include: - Tolerance of its calming effects on anxiety means more alcohol is needed, which can lead to abuse, tolerance, and potentially addiction. - The euphoric, calming effects of alcohol go away, and feelings of depression set in as blood alcohol content falls. This triggers anxiety. - Alcohol interrupts the production of serotonin and other feel-good hormones in the brain, which actually leads to worsening anxiety over time as the feedback loop is disrupted. More alcohol is needed to approximate those feelings until use has become abuse and addiction. It is also possible for those with a long-term alcohol use disorder to develop anxiety that they may not have had before. The reason for this is that the altered brain activity over time makes recovery from traumatic or painful events more difficult, which can lead to chronic anxiety. When both disorders—alcohol use and anxiety—are co-occurring, things become more challenging, and seeking professional help is the best way forward to regain balance and sobriety while getting the help you deserve and need for your anxiety. Treating Co-Occurring Disorders When someone is in treatment for co-occurring anxiety and alcohol use disorders, dual diagnosis treatment is best. It treats both disorders in a coordinated approach so that neither one can sabotage the healing process for the other, which can happen if they are treated separately and sequentially. The integrated approach your care team uses will be completely individualized to you and your symptoms, mental and physical health history, and circumstances. Your treatment plan might include: - Medications to ease withdrawal and ongoing cravings - Medication for easing symptoms of anxiety - Individual behavioral therapies such as cognitive-behavioral therapy or dialectical behavior therapy - Education about mental health and addiction - Education about coping skills, identifying and avoiding triggers, and how to navigate life post-rehab - Group counseling - Support groups - Aftercare or alumni follow-up care When alcohol and anxiety combine and lead to a diagnosis of co-occurring disorders, remember that help is available. Call The Right Step Houston Today to Talk About Dual Diagnosis Treatment The Right Step Houston can answer your questions and listen to your story. How can we help? We offer a range of evidence-based therapies that are proven effective in treating co-occurring disorders such as alcohol addiction and anxiety. Our program offers inpatient and outpatient options for people from all walks of life. Make The Right Step Houston your next phone call. Dial 1.844.768.0169, or if you prefer to connect online, simply fill out this easy form.
The Moral Economy of Food Mabel Winter 13 June 202313 June 2023 What can conflict over mills in early modern England tell us about food security today? Mabel Winter on market and moral economies. Read Article "The Moral Economy of Food" Facial Recognition, Medieval Style Trevor Dean & Patricia Skinner 2 December 202220 December 2022 Did medieval states engage in any sort of surveillance of populations based on the collection of their personal data? Trevor Dean and Patricia Skinner ask what we can learn from lists and facial descriptions of police in Italian cities. Read Article "Facial Recognition, Medieval Style" Scarcity and Risk in the Tropics Julia McClure 27 July 202213 January 2023 What is the difference between poverty and scarcity? Julia McClure explores how different communities and societies mitigated the risks of resource scarcity before capitalism created poverty. Read Article "Scarcity and Risk in the Tropics" 'A Real Kind of Emerging Subculture': Basketball and Black Identity in Urban Britain Michael Romyn 13 June 20224 January 2023 From the 1970s onwards, basketball became an important source of expression, identity, and resilience in many Black British communities. Michael Romyn explores. Read Article "'A Real Kind of Emerging Subculture': Basketball and Black Identity in Urban Britain" The Twisted Histories of a Colombo Canal Sujit Sivasundaram 13 December 202129 October 2022 What can the twisted histories of one Sri Lankan canal tell us? Sujit Sivasundaram on how the coastal environment of Colombo has been colonised and marketised, but in turn creates its own paths, through winds, waves and waters as well as… Read Article "The Twisted Histories of a Colombo Canal" Ridley Road May Robson 25 November 202119 January 2023 In this episode of the History Workshop Podcast, we hear an oral history of Ridley Road Market, in east London. Read Article "Ridley Road" The Political Environment Elly Robson 15 November 202129 October 2022 As the global ecological crisis deepens and spreads through virus, fire and flood, Elly Robson introduces a new HWO series on The Political Environment. How have politics shaped the way we identify ecological problems and solutions, and how… Read Article "The Political Environment" Activist Streets Daniel Frost 15 March 20211 October 2022 How did Black activist organisations fight racism in the London suburbs? Daniel Frost finds that they did so – in districts like Croydon and Thornton Heath – through association and alliance with the struggles of inner-city locales. Read Article "Activist Streets" Immigrants in Urban Politics in Later Medieval England Bart Lambert 4 March 202129 October 2022 Just how much immigrant newcomers should have a voice in the political life of their new communities is a question that has occupied people for centuries. Bart Lambert explores the twists and turns of that issue in later medieval England in… Read Article "Immigrants in Urban Politics in Later Medieval England" Pedestrian Streets Mariana Mogilevich 22 February 20211 October 2022 How did 1970s New York become a laboratory for a grand experiment in 'returning streets to the people'? Mariana Mogilevich argues that street life and politics in Midtown Manhattan became central to the inception of a new form pedestrian… Read Article "Pedestrian Streets" Everyday Streets Bob Pierik & Gamze Saygi 8 February 202120 January 2023 Who owns the street? Bob Pierik and Gamze Saygi investigate spatial segregation by mapping everyday mobility in eighteenth-century Amsterdam. Read Article "Everyday Streets" Women's Streets Tiina Männistö-Funk 1 February 202120 January 2023 How do we see walking women? Using archival photography from 1950s and 1960s Turku (Finland), Tiina Männistö-Funk argues that women's care and bodily presence shapes cities as much as concrete and asphalt do. Read Article "Women's Streets" Whose Streets? Peter Jones 25 January 202129 October 2022 This opening article in the 'Whose Streets?' feature considers what it means to live through the jarring collapse of public life in the midst of a pandemic and how this moment might stimulate new radical histories of the urban commons. Read Article "Whose Streets?" 'Building Welfare States': Report on an Online Conference Ed DeVane 19 November 202029 October 2022 Amidst the second wave of the COVID-19 pandemic it seems that virtual conferences are here to stay. In the first half of this post, PhD student Ed DeVane reflects on the experience of 'doing' an online event. The second half of this… Read Article "'Building Welfare States': Report on an Online Conference" Police, Press & Race in the Notting Hill Carnival 'Disturbances' Jessica White 31 August 202029 October 2022 On the 7th May 2020, at the peak of the Covid-19 pandemic in the UK, news broke that this year's […] Read Article "Police, Press & Race in the Notting Hill Carnival 'Disturbances'" Dan Chatterton's London Andrew Whitehead 29 June 202020 January 2023 Walk in the footsteps of Dan Chatterton, who was - in his own words 'one of the revolutionary type of workers for political and social advancement'. Read Article "Dan Chatterton's London" The Memory Map of the Jewish East End Rachel Lichtenstein 2 April 202029 October 2022 A new digital resource allowing users to explore former sites of Jewish memory in East London went online this week. On it you will find audio interviews, photographs, and essays about more than 70 sites (we hope to include more in future)… Read Article "The Memory Map of the Jewish East End" The QE2 Bridge and the Private Finance Initiative (PFI) Hangover David Anderson 27 January 20207 January 2023 What are the origins of the Private Finance Initiative (PFI) hangover? David Anderson drives onto the QE2 bridge to analyse the legacies and landscapes of PFI. Read Article "The QE2 Bridge and the Private Finance Initiative (PFI) Hangover" Walking as radical history on the East End Women's Museum Trail Charlotte Tomlinson 20 January 202012 January 2023 What does the heritage trail format offer to the communication of radical histories? Charlotte Tomlinson introduces the East End Women's Museum's (EEWM) Brilliant Women of Whitechapel, Bow and Barking Heritage Trail, which explores… Read Article "Walking as radical history on the East End Women's Museum Trail" Food Walking and the Itineraries of Radical History Charlie Taverner 1 October 201912 January 2023 Charlie Taverner reflects on how historical food walks can enrich radical history by opening new up trajectories and generating unexpected perspectives on the experience of the pre-industrial city. Read Article "Food Walking and the Itineraries of Radical History" Performative walking round the radical pubs and coffee houses of London Stuart Butler 16 May 201921 January 2023 Stuart Butler writes on performative walking along the Thames, tracing the life of Thomas Spence, a leading revolutionary in 18th century England, advocating for the complete common ownership of land. Read Article "Performative walking round the radical pubs and coffee houses of London" A Family History from Berlin to Glasgow: Memories of Dumbarton Road by Martin Chalmers Esther Kinsky 7 May 201913 December 2022 A glimpse into post-war Glasgow life, via the Ruhr, from the unpublished memoirs of Martin Chalmers Read Article "A Family History from Berlin to Glasgow: Memories of Dumbarton Road by Martin Chalmers" Researching race in contemporary Britain Kieran Connell 30 April 201921 January 2023 Kieran Connell takes us through his personal journey on what brought him to researching Handsworth, an inner city locality in Birmingham, and what it might tell us about multiculturalism in modern Britain. Read Article "Researching race in contemporary Britain" Peterloo: Place Matters Katrina Navickas 24 April 201913 December 2022 What is the role of space and place in the commemoration of Peterloo? Katrina Navickas explores the massacre's legacy in the streets of Manchester. Read Article "Peterloo: Place Matters" Stop and search and the politics of policing Jonah Miller 10 April 201913 December 2022 These are strange times in the politics of the police. In a companion piece to his History Workshop Journal article, Jonah Miller explores the historical background to debates over stop and search. Read Article "Stop and search and the politics of policing" Yellow Vests in Context: Haussmann, Urban Transformation and Street Violence Cynthia Green 25 March 201929 October 2022 Yellow Vests are rioting in the streets of Paris and calling for President Macron to resign. They are doing it in the streets that Baron Haussmann built to stop urban unrest 190 years ago. Read Article "Yellow Vests in Context: Haussmann, Urban Transformation and Street Violence" Activist Selly Oak: Public History and Community Activism in Birmingham Josh Allen 13 March 20191 November 2022 Birmingham's once-vibrant suburb of Selly Oak provides a clear cut case study from very close to home of contemporary capitalism shattering a community in pursuit of profit. Read Article "Activist Selly Oak: Public History and Community Activism in Birmingham" Underneath the Arches: Gilbert & George, Homosociality, and Post-War Reconstruction Greg Salter 28 January 201913 December 2022 Gilbert & George's Underneath The Arches seems to stray from the certainty of a specific location and structure, allowing the experience of homelessness to be transfigured into a performance that evokes queer masculinity, the uncanny… Read Article "Underneath the Arches: Gilbert & George, Homosociality, and Post-War Reconstruction" "Bread in those days was like gold!" A survivor's account of the Siege of Leningrad Mikael Kai Zakharov 28 November 201829 October 2022 A moving first-hand account of the Siege of Leningrad from a civilian who lived through it, transcribed and introduced by his great nephew, Mikael Kai Zakharov. Read Article ""Bread in those days was like gold!" A survivor's account of the Siege of Leningrad" Marx's London Thomas Jones 19 November 201820 January 2023 Celebrate Karl Marx's 200th birthday with 10 stops on a new History Workshop audio tour of Marx's London Read Article "Marx's London"
Tonight, Oprah Winfrey, 70, returned to network television. And this time, she covered a topic close to her heart. An Oprah Special: Shame, Blame and the Weight Loss Revolution, aired on March 18 at 8 p.m. on ABC, and will stream the next day on Hulu. It explores the trend of using weight loss medications and the controversy surrounding them. Oprah's shared her personal weight loss journey and her experience taking a weight loss medication. Her goal for the special is to release the judgement, shame, and stigma around weight. During the special, Oprah reflected on the body shaming she experienced throughout her career. "I took on the shame that the world gave to me," she recalled. "The number one thing I hope people come away with is knowing that [obesity] is a disease, and it's in the brain," Oprah says in a new clip about the special on Good Morning America. Ahead of the special's airing, Oprah announced that she was stepping away from the board of WeightWatchers. She was concerned that there would be a "conflict of interest." "I decided that because this special was really important to me and I wanted to be able to talk about whatever I wanted to talk about," she explained. "It is a very personal topic for me and for the hundreds of millions of people impacted around the globe who have for years struggled with weight and obesity," she told Oprah Daily earlier this month. "This special will bring together medical experts, leaders in the space and people in the day-to-day struggle to talk about health equity and obesity, with the intention to ultimately release the shame, judgment and stigma surrounding weight." The latest news comes amidst Oprah's own weight loss journey, including her recent admission that regular exercise, nutrition, and weight-loss medications are helping her live a healthier life. Here's everything to know about her health. How did Oprah lose weight? Oprah's 2021 knee surgery actually jumpstarted her recent weight loss. "After [my] knee surgery, I started hiking and setting new distance goals each week. I could eventually hike three to five miles every day and a 10-mile straight-up hike on weekends," Oprah told PEOPLE. "I felt stronger, more fit and more alive than I'd felt in years." Working towards these fitness goals also helped Oprah achieve a personal goal. "In Hawaii, I live on a mountain, and there's this big hill—I used to look out the window every morning and say, 'God, one day I want to walk up that mountain,'" she said in her PEOPLE cover story. "Last year over Christmas I did it… It felt like redemption." In December, Oprah shared with PEOPLE that she was close to her "goal weight" of 160 pounds, but emphasized that her journey was not about a number but rather about living a more vibrant life. Does Oprah use weight-loss medications? In September 2023, the multihyphenate hosted Oprah Daily's "The State of Weight" panel. At that time, she shared that she wasn't interested in taking weight loss medication. "Shouldn't we all just be more accepting of whatever body you choose to be in? That should be your choice," she said. "Even when I first started hearing about the weight loss drugs, at the same time I was going through knee surgery, and I felt, 'I've got to do this on my own.' Because if I take the drug, that's the easy way out.'" But in December 2023, Oprah Winfrey opened up to PEOPLE about how her perspective on weight loss medication has changed over time. "I now use [weight loss medication] as I feel I need it, as a tool to manage not yo-yoing," Oprah told the publication, without naming the specific drug she takes. "The fact that there's a medically-approved prescription for managing weight and staying healthier, in my lifetime, feels like relief, like redemption, like a gift, and not something to hide behind and once again be ridiculed for. I'm absolutely done with the shaming from other people and particularly myself." Oprah shared that she started the medication before Thanksgiving "because I knew I was going to have two solid weeks of eating." Instead of gaining eight pounds like she did last year, she gained half a pound, per the publication. But she emphasized that weight loss medication has not been a "magic bullet" in managing her weight. "It's everything," she said, referencing her health and fitness routine. "I know everybody thought I was on it, but I worked so damn hard. I know that if I'm not also working out and vigilant about all the other things, it doesn't work for me." Taking a weight-loss medication silenced Oprah's 'food noise' During the primetime special, experts claimed that new medications like Ozempic or Wegovy can silence "food noise" and help people lose weight. Food noise refers to "constant and persistent thoughts" about food, "to the point of feeling as if [subjects'] lives revolved around food," according to research published in the academic journal Nutrients. Oprah shared an anecdote about how taking a weight-loss drug helped quiet her food noise. "I'm not constantly thinking about what the next meal is going to be," she said. "I can eat a half a bagel and be fine…I just want less of the bagel." Does Oprah use Ozempic? The media mogul hasn't shared exactly which weight loss medication she's on—yet. Oprah also made it clear that everyone's weight loss journey is different. "Whatever your choice is for your body and your weight health, it should be yours to own and not to be shamed about it," she said." "I'm just sick of it, and I hope this conversation begins the un-shaming of it." As she's gotten older, Oprah added that she's learned to let go of the shame she's felt about her body over the years. "It was public sport to make fun of me for 25 years," she said. "I have been blamed and shamed, and I blamed and shamed myself." Now, she has a new perspective on her weight loss journey. "I realized I'd been blaming myself all these years for being overweight, and I have a predisposition that no amount of willpower is going to control," she told the publication. "I had an awareness of [weight loss] medications, but felt I had to prove I had the willpower to do it. I now no longer feel that way." Watch Oprah speak candidly about her relationship with weight and shame below: How does Oprah exercise? Weight loss medication isn't the only tool in Oprah's kit: She's also an avid exerciser. During her weight loss special, she told viewers that she hikes three to five miles per day and also does "weight resistance training." Back in 2017, she told The Hollywood Reporter that she hits her home gym soon after waking up. "I have a fantastic Octane elliptical machine that is like a power mover—you can increase the length of your stride and your arm movement," she said. "I'll do 20 minutes on the elliptical and 30 minutes walking on the treadmill. I start out at the Level 3 incline setting and then every minute I add to the incline until I get to 12 or 15. And then I do sit-ups." After getting her heart rate up, Oprah said she'll often cool down with 10 to 20 minutes of walking or sitting meditation. Back in 1994, Oprah ran the Marine Corps marathon to celebrate her 40th birthday. (She even wore the bib number 40.) Oprah finished with a time of 4:29:15, which put her 8,210 out of 12,716 finishers. (She later told a fan that she couldn't run any more marathons due to a knee injury.) Despite her dedication to fitness, Oprah still doesn't love to work out. "Here's the thing about exercise: I still hate it so much," she said on Today in 2020, per PEOPLE. But, she added, "I still do it." "I think everyone's waiting to love it," she continued. "You're not going to love it, but you do the thing you need to do to make yourself feel whole and well." Does Oprah still support WeightWatchers? Fans were floored in late February when Oprah Winfrey announced that she was moving on from the board of WeightWatchers. The talk show host didn't give a lot of explanation at the time. However, it came just a few months after the she shared that she used weight loss medications as part of maintaining her health. Now, the 70-year-old opening up about why she left her nearly decade-long partnership with the company. Essentially, the move was was linked to her upcoming special on weight loss medications, Oprah shared during a recent episode of Jimmy Kimmel Live! Oprah's decision to leave WeightWatchers was based on her drive to speak freely in her upcoming special, An Oprah Special: Shame, Blame and the Weight Loss Revolution. "I decided that because this special was really important to me and I wanted to be able to talk about whatever I wanted to talk about, and Weight Watchers is now in the business of being a weight health company that also administers drug medications for weight," she said on said on a recent episode of Jimmy Kimmel Live! "I did not want to have the appearance of any conflict of interest." During the interview, Oprah quipped that WeightWatchers "almost" cried when she announced her resignation. But, she will still be involved in the company, writing in her original resignation statement, "I look forward to continuing to advise and collaborate with WeightWatchers and CEO Sima Sistani in elevating the conversation around recognizing obesity as a chronic condition, working to reduce stigma, and advocating for health equity." Korin Miller is a freelance writer specializing in general wellness, sexual health and relationships, and lifestyle trends, with work appearing in Men's Health, Women's Health, Self, Glamour, and more. She has a master's degree from American University, lives by the beach, and hopes to own a teacup pig and taco truck one day.
Quality locking nuts for all applications. When you need a job done, you want to be sure it gets done well. That's an idea that we believe in, and that we've built our business around. When your work requires quality locking nuts for all applications, you need a company you can trust to get the job done right. It's a fact that our reputation has been built on providing customers with the tools they need to do their jobs securely and safely. A Locknut That Won't Let You Down Locknuts are what you call nuts that get tightened against another nut to keep it from coming loose. Locknuts are commonly used in applications where it is essential to prevent vibrational loosening, such as on vehicles or in machinery. Locknuts typically have a higher level of resistance to vibration than standard nuts. To make a locknut, start by threading a nut onto a bolt. The nut should be threaded on far enough so that it can bottom out against the bolt head or another nut. Next, you're going to put in a second nut and tighten it down against the first nut. The second nut should be turned until it is snug against the first nut. The friction between the two nuts will keep them from turning. You can also add a washer between the two nuts for additional protection. Finally, cut off any excess bolt length, and you're done! Locknuts are a simple way to prevent nuts from loosening. Be sure to check out our selection of locknuts and other fasteners today. The Only Locknut You'll Ever Need New to locknuts? Then you're in the right place. Our locknut is a great, affordable introduction to the world of nuts with locks. Our locknuts are the last locknuts you'll ever need! Because they're so durable and reliable, you'll never have to worry about whether or not your screws are in place—and you can focus on other things. Locknuts are a kind of nut that prevents screws from becoming loose due to vibration. They work by screwing onto the screw and then tightening over it, which keeps the screw in place. Once screwed on, the locknut is not easily removed, so it is important to tighten it properly. With this locknut, you'll never have to worry about it giving out on you or letting you down. Just take it from us: You'll never need another locknut again! No more complicated, time-consuming projects—just simple, straightforward solutions that everyone can use and understand. That's what we're all about at TOTALBEARINGS, and we're proud to stand behind the products we make and guarantee that they'll work for you. Better than your average locknut! Get the best locknuts from TOTALBEARINGS. One-Stop-Shop for Locknuts. - Application - Cleaning Tips for Locknuts Locknuts, also known as jam nuts, are a type of nut that is used to secure another nut in place. Unlike standard nuts, which can be tightened or loosened by hand, locknuts have a special mechanism that locks them into place. They're especially well-suited to applications where a lot of pressure is needed, such as in plumbing or wiring. There are a bunch of locknuts out there, and they can be made from different materials depending on the application. In most cases, locknuts are made from steel or brass. To install a locknut, first determine the size and type of nut needed for the application. Then, attach the nut to the bolt or rod and tighten it by hand. Next, use a wrench to tighten the nut until it is snug against the surface. Finally, use a second wrench to hold the first nut in place while you tighten the locknut. This will ensure that the locknut is properly secured. Locknuts are an essential part of keeping your machinery running smoothly. Not only do they help to keep parts in place, but they also prevent damage by keeping them from vibrating loose. However, locknuts can become dirty and ganged up over time, making it difficult to remove them when necessary. For those of you who don't know, locknuts are a type of nut with threads on the inside that can be tightened by a set screw. The tips mentioned below will help keep your locknuts clean of debris and rust. First, always use a clean rag when wiping down locknuts. This will scrub away any dirt and grime that's built upon the surface. Second, be sure to lubricate locknuts regularly with light oil or grease. This will help to keep them from rusting and make it easier to remove them when necessary. Follow these tips to clean your locknuts and keep them in good working condition. Don't waste time, buy a locknut Just about every machine you use in your life contains a locknut. And if it doesn't, it probably uses something like a locknut to hold things together. Locknuts are used in all sorts of equipment, from the machines that make cars to the machines that help us make food and medicine. They're also used in our phones, computers, and other technology. Basically, there's no telling how many locknuts you might come across during the course of your day—but be sure you're prepared if you find yourself needing one! When you're working with machines, whether it's a train or a radio or a satellite, there's always going to be a lot of activity and moving parts. And when there are moving parts, you can't just rely on the friction of the machine and its own parts to hold it all together. You need something to anchor everything together so it doesn't fall apart. Locknuts are one such method of keeping fasteners and machine parts together. They offer simple security—a way to make sure that the bolts don't get loose during the operation of the machine and do some damage to itself or someone around it. When choosing locknuts for your construction project, look for ones made from high-grade materials that have been extensively tested for performance and durability under pressure. The Nut That Makes The Difference So what is a locknut? And why would it make a difference? Well, let's start with the basics: A locknut is a nut that has been threaded to match a bolt and tightened with a wrench. A locknut, or locking nut, has threads that are deformed slightly so as to keep them from coming loose. This is particularly important when the nut is used in an application where it can't be tightened by hand on a regular basis. When you think about the parts that make up a machine, it's easy to overlook the nuts. But nuts have a huge impact on how well a machine will work and for how long. Take locknuts, for example. These are nuts that have a nylon patch or thread-locking compound on them which helps to keep the nut from loosening. Not only do they help keep fasteners tight, but they also help to reduce vibration and wear. Which nuts have been found to be safe? If you're trying to figure out which nuts are right for your machining needs, we've got one word for you: Locknuts. Locknuts are one of the most popular fasteners in the world, and they're used everywhere from cars to furniture to machinery. With a low profile and high degree of reliability, these nuts are found pretty much everywhere. Look at this list of reasons why you need to add Locknuts to your application. You can use them for more than just locking up nuts. That's right—the Locknut is so versatile, it can lock up bolts too! And with its engineering-grade metal construction and heat-resistant coating, it can handle just about any job you throw at it. They can be used for non-locking purposes as well, in case you need to loosen something up. Because the Locknut isn't always just about locking stuff down—sometimes you've got to loosen things up a bit! The Locknut's hexagonal shape means it fits most standard wrenches, so if you need to tighten or loosen something, this little guy has got you covered! Locknut has been proven in industry after industry to be safe for your machines' parts and components. With Locknut, you'll never have to worry about whether or not the temperature of your machine will run too high or too low—Locknut always delivers a consistent supply of nuts that you can count on to keep your machines working at their optimal level of performance. Make sure your locknuts are working as they should! You probably don't even know what a locknut is, and that's okay. Not many people do. But, in fact, a locknut is an essential part of your life—it's the little thing that keeps your wheels from falling off when you're driving. Locknuts are those little things that allow you to go about your day-to-day business with the comfort to know that, no matter how fast you're driving, or how shaky the road, your wheels aren't going to fall off. Without them, well… it's just not worth thinking about. So if you want to be sure your locknuts are doing their job just as they should be—allowing you to drive safely and effectively—it might be time to consider buying some new ones. And there's only one place to buy them: TOTALBEARINGS. Locknuts are what you need to keep your bolts secured When you need to secure your bolts, there's no better option than locknuts. Locknuts ensure that your bolts stay in the right place, so you don't have to worry about them moving or coming loose on their own. This is especially important for vital mechanical joints and components, as well as construction projects, where a bolt that comes loose could lead to serious consequences. A locknut is what you need to keep your bolts secured, and TOTALBEARINGS has a great line of locknuts that are sturdy and dependable. It's easy to overlook the danger of loose screws. Loosened bolts pose a huge safety risk. Locknuts, which lock the wheels of your car, motorcycle, or scooter to the axel, is essential if you own a vehicle—you just never know when your tires might come flying off and cause an accident. A locknut or locking nut is a nut with a tab on it that fits into a groove in the screwdriver, to keep it from coming loose. It's used in conjunction with a locking washer, which has a protrusion that fits into the hole in the locknut. Together, they ensure that the nut doesn't loosen no matter how much vibration or movement it experiences. You could technically use any kind of nut to secure a bolt, but sometimes it's useful to use a locknut instead of a plain nut. For one, locknuts are designed specifically to resist looseness from vibration. They typically have a circular or spiral groove cut into them, which adds friction and helps keep them tight. Locknuts also tend to be thicker and stronger than regular nuts, so they can better handle higher loads without stripping or breaking. And many types of locknuts come with an attached washer for added stability and protection against loosening. So whenever you're looking for the best way to keep your bolts secure, you need a locknut—no questions asked. A locknut is a nut that has been specifically designed to resist loosening under vibration or torque. There are many different kinds of locknuts, each type differing in the advantages and disadvantages it provides. The most common type of locknut is the nylon insert locknut, which uses a plastic insert to grip the thread and prevent movement. Another common type of locknut is the all-metal locking nut, which uses metal teeth to grip the thread. Both of these types of locknuts are effective at preventing loosening, but they have different strengths and weaknesses. Nylon insert locknuts are less likely to damage the thread, but they can back out under high loads. All-metal locking nuts are more likely to damage the thread, but they are much less likely to back out. The easiest way to remove a locknut is with a pair of pliers. Start by aligning the teeth of the pliers with the ridges on the locknut and turning counterclockwise to loosen. If that doesn't work, try using another tool to hold the nut still while you turn the bolt clockwise. If neither of those options works, lubricate the nut and try again. Yes, locknuts can be reused! You just need to make sure you put them back in the right place. If you don't have a diagram of where they should go, though, it might be easier to have a professional install them. Also, it's important to note that over time the threads on a locknut may wear down and eventually they may not be able to hold the nut in place as securely as they once did. If this happens, you can always replace the locknut with a new one. When you have two nuts that are tightened against each other, an elastic barrier is formed between the two faces of the nuts. As the top nut moves due to vibrations, It also serves to compress the elastic barrier and hold it in place. This is why a good locknut should always be used in applications where there is a potential for vibration.
Medieval Home Decoration If you're looking for some unique home decor ideas, why not take a page from medieval times? From tapestries to ironwork, there are a variety of ways to add a piece of history to your living space. Let's take a look at how medieval people decorated their homes and how you can incorporate this style into your own. Tapestries were one of the most common forms of decoration in medieval homes. Tapestries were woven wall hangings that featured elaborate designs and vivid colors. They often depicted scenes from religious texts, such as Bible stories or mythological tales. Tapestries were expensive and took months or even years to complete, so they were usually reserved for wealthy households who could afford them. Today, you can recreate the look with modern-day tapestries that are just as beautiful but much more affordable. Medieval furnishings were made from natural materials like wood, stone, clay, and leather. Furniture was simple in design and function—tables were used for eating meals while chairs provided comfort during long conversations around the fire. Beds had wooden frames with thick blankets or mattresses filled with straw or feathers for added warmth on cold nights. While these items aren't exactly easy to find today (unless you shop at antique stores!), you can still get the same look with modern pieces that have been given an aged finish to make them look more authentic. Ironwork was also popular in medieval homes, particularly as decorative door hinges and handles that added an extra touch of elegance to otherwise plain doorways. Ironwork also had practical uses—it was often used to secure doors shut or strengthen window frames against strong winds and rainstorms. You can easily recreate this look today by adding wrought iron door hardware to your doors or using iron brackets to frame windows in your home. With its bold colors and intricate designs, medieval home decor is full of timeless charm that will add character and sophistication to any space. Whether it's tapestries, furnishings, or ironwork – there are plenty of ways you can recreate this ancient style in your own home! Get creative with it – who knows what looks you might discover. How did the decoration of homes change over time? The decoration of homes has changed drastically over time, from ancient civilizations to modern life. In the earliest eras, walls were typically adorned with frescoes and other paintings that depicted important religious or cultural stories. People also decorated their homes with fabrics and tapestries or woven rugs to provide a comfy atmosphere and additional insulation against the elements. Additionally, furniture was made out of wood or metal frames filled with straw and linen stuffing for added comfort. As technology advanced it allowed people to create beautiful items of furniture in more intricate designs, such as chairs crafted from ivory or wood topped with carved hand rests and upholstered cushions. Brass accents could be added along with marble floors that showcased ornate patterns. Later on during the 1700s wallpaper became popular in Europe; allowing people to freely express their tastes by covering walls in colorful prints featuring geometric motifs and architectural scenes as well as portraits of historical figures like kings, queens, gods, goddesses, etc. Home decor trends have shifted from classic collectibles towards a contemporary look – think large mirrors mounted on walls surrounded by decorative lights for dramatic effect plus geometric shapes embedded in carpets for visual interest. Art is also widely used inside homes nowadays; be it reproduction prints based off famous masterpieces or abstract interpretations created by local artists combined together tastefully. And instead of spending money on expensive pieces sourced from different parts of the world, anyone can now access affordable mass-produced items easily thanks to online shopping sites which have revolutionized both architectural design decisions regarding a home's interior decoration choices today. What kinds of materials did they use? The kinds of materials used in the construction of buildings and other structures vary based on the location, purpose, and time period they were constructed. Common building materials today include wood, concrete, steel, stone, brick, and glass. In ancient times construction materials included mud bricks which are still used in some parts of the world such as Africa for residential housing; stones for walls; wattle and daub (a mix of soil or clay mixed with straw) for plastering walls; thatch from palm leaves or reeds as roof covering; timber from trees to provide beams and posts to support roofs; ceramic tiles and mosaics for decorative floors; metals such as lead or copper alloys to make pipes for water collection, waste disposal systems, etc. In most modern cities you can find a variety of different building material types being used including aluminum composite panels (ACPs), fiber cement board (FCB), insulated concrete forms (ICF) systems consisting of foam blocks forming a hollow core system that hold poured concrete within it making it easier to construct curved walls or build multi-story buildings quickly without using traditional methods like brickwork/block work where each layer needs curing before continuing further upwards. Steel is also commonly used in modern structures due to its strength while remaining lightweight relative to other strong material options like reinforced concrete which adds significant weight per square meter provided by something like steel reinforcing bars inside the structure's frame during the construction phase creating stronger connections between components than could be achieved with just one type of material alone – creating additional resistance against lateral forces subjecting many structures like bridges during high wind scenarios beyond what local codes allow without incorporating this kind of functional design element into their foundation/framework plans.
How Baby Babble May Help Babies and Kids Learn Languages Faster Although there are debates on what is "baby babble," there's no denying that it helps babies develop their language skills better. Whenever we see babies, we always talk to them in a singsong voice and mix it with some babble. Although it may not make sense to adults, it actually helps babies in the long run. By fusing the appeal of music with speech, babies get a better sense of how to string words in a sentence and how they sound. But how does baby babble work with multilingual families like Filipinos? Understanding the Babble in a Bubble Because babies are still developing their tongue and mouth motor skills, they often produce syllables instead of the whole word. We often call this "baby babble"; "Da", "Ma", "Um", and many others serve as substitutes while refining their tongue's movements to produce more precise sounds. While we use English as a basis for these babbles, some have shown that the syllables they make can also work with other languages like Spanish because they share the same sounds in both consonants and vowels (Oller and Eilers, 1982; de Boysson-Bardies, Sagart, and Durand, 1984). So when we babble to our babies ourselves, they learn by watching how our mouths move. It's also the same technique speech pathologists use to help children with verbal delays with their own approach like the PROMPT technique (Rogers, Hayden, Hepburn, Charlifue-Smith, Hall, and Hayes, 2006; Brown, Cosgriff and French, 2008). However, these studies often assume that the child is only learning one language which is whatever the parents' native language is. But how does that work with a Filipino family wherein each member knows a minimum of two languages? A Multi-Lingual Perspective for Baby Babble As home to more than 180 native languages plus inherited languages like English, Spanish, and Chinese, the Philippines is home to linguistic marvels who are at least bilingual. They know Filipino and English, and then sometimes, have a third language which we, as parents, often encourage our kids to learn or the school requires them to learn. With easily accessible language learning apps, it's no surprise that kids and babies can stun their parents when they learn another language that the parents never taught or even know how to speak. However, this is because of two premises: the first one is that babies are considered "global citizens" wherein their developing brains are developing connections that can learn the language (Werker, 2003; Shulsky, Baker, Chvala, and Willis, 2017), and the second one is that every language has a parent language which means some languages will have similarities to one another (Torpsten, 2011). Southeast languages like Tagalog and Bahasa are one such example because they share syllables and some grammatical rules. Thus, they end up sharing some similar words such as Ako and Aku, meaning "I" in Tagalog and Indonesian respectively (Wardana, Widayati, Taib, and Iqbal, 2022). Coupled with the Philippines' colonial history wherein the Spanish conquered the Philippines, Filipinos also developed an affinity for learning Spanish because of the shared syllables. We can already see this in the use of the Chavacano language, one that is commonly spoken in Zamboanga (Reid, 1982; Zorc, 1986). Baby Babble: A Nonsensical But Necessary Foundation For Multilingualism Some studies have argued that babbling to our babies isn't completely useful but that's because it's assuming that we are often teaching and speaking in English. These studies often advocated for the use of Parentese. Unlike Baby Babble, Parentese creates full sentences and emphasizes on syllables of the words whereas the former only focuses on the syllables. However, Baby Babble does create a foundation for the mouth's motor skills and accents which are important in Asian languages. Chinese, Japanese, and Tagalog — these are some of the languages wherein even one mispronounced syllable will change the word's entire meaning! Although there are times we'd like to jump to Parentese right away, sometimes, it's better to do the scenic route especially if you're planning to teach multiple languages. Not all languages share the same syllable and getting babies used to learning various ones may make it easier to survive the demand of being bilingual in the long run. Brown, T., Cosgriff, T., & French, G. (2008). Learning style preferences of occupational therapy, physiotherapy and speech pathology students: a comparative study. Internet Journal of Allied Health Sciences and Practice, 6(3), 7. de Boysson-Bardies, B., Sagart, L., & Durand, C. (1984). Discernible differences in the babbling of infants according to target language. Journal of child language, 11(1), 1-15. McConnell, E. K. (2008). From baby babble to childhood chatter: Predicting infant and toddler communication outcomes using longitudinal modeling (Doctoral dissertation, University of Kansas). Oller, D. K., & Eilers, R. E. (1982). Similarity of babbling in Spanish-and English-learning babies. Journal of Child Language, 9(3), 565-577. Reid, L. A. (1992). On the development of the aspect system in some Philippine languages. Oceanic Linguistics, 65-91. Rogers, S. J., Hayden, D., Hepburn, S., Charlifue-Smith, R., Hall, T., & Hayes, A. (2006). Teaching young nonverbal children with autism useful speech: A pilot study of the Denver model and PROMPT interventions. Journal of autism and developmental disorders, 36(8), 1007-1024. Shulsky, D. D., Baker, S. F., Chvala, T., & Willis, J. M. (2017). Cultivating layered literacies: Developing the global child to become tomorrow's global citizen. International Journal of Development Education and Global Learning. Torpsten, A. C. (2011). Global citizenship and lingual identity: The ability to perform in different lingual settings. Citizenship, social and economics education, 10(1), 37-45. Wardana, M. K., Widayati, D., Taib, R., & Iqbal, M. (2022). LEXICOSTATISTICS OF MALAY, TAGALOG AND ILOCANO LANGUAGES: A COMPARISONAL HISTORICAL LINGUISTIC STUDY. JURNAL EDUCATION AND DEVELOPMENT, 10(3), 475-479. Werker, J. F. (2003). Baby steps to learning language. The Journal of pediatrics, 143(4), 62-69. Zorc, R. D. (1986). The genetic relationships of Philippine languages. In FOCAL II: Papers from the Fourth International Conference on Austronesian Linguistics. Pacific Linguistics. More about language development in babies and kids? 5 Reasons Why Teaching Babies Sign Language Helps How Babies Now Can Grow Up Bilingual WATCH: Marj Suarez's TikTok Video About Being Bilingual Made Us Giggle
NK cell-related immunotherapeutics, such as tumor-specific monoclonal antibodies (mAbs) to elicit NK cell-mediated ADCC against tumor cells, are being developed for the treatment of cancers. As an example, Rituximab and obinutuzumab, two mAbs that target CD20, have long been used to treat varied B cell malignancies. Rituximab is a type I, chimeric anti-CD20 mAb (mouse variable region + human IgG1 Fc region), whereas obinutuzumab is a type II, fully humanized IgG1 mAb that adheres to a partly overlapping, but distinct epitope on CD20 compared to rituximab and was glycoengineered to decrease fucosylation in the Fc region, resulting in improved binding affinity for FcγRIIIa (CD16a) which enhanced ADCC.1–3 To determine the prospective clinical effectiveness of newly designed tumor-specific mAbs, NK cell-mediated ADCC must be assessed. Donor cell variability, on the other hand, can influence the degree of NK cell-mediated ADCC. As a result, in addition to determining cytolytic activity, the number and activation state of the donor NK cells must be determined. Conventional cytotoxicity assays are time-consuming, and characterizing donor effector cells necessitates additional downstream assays. Anti-hCD20 mAbs, similar to rituximab and obinutuzumab, were used in this study to see if a multiplexed, high throughput assay that measures target cell killing, expression of NK cell phenotypic markers, and effector protein secretion could be used to distinguish between mAbs' ADCC potency and provide insight into their potential treatment efficiency across donors. Figure 1. Schematic diagram of the workflow for the analysis of NK cell cytotoxic function, along with assessment of the NK cell activation state and cytokine/effector protein release using the iQue® Human NK Cell Killing Kit. Effector cells (Cellero; human PBMCs or enriched, negatively selected human NK cells) were thawed and allowed to recover in media (Corning; RPMI 1640 medium with 10% fetal bovine serum for enriched NK cells, or RPMI 1640 containing 10% FBS, 1% non-essential amino acids, 1% sodium pyruvate, and 1% Pen/Strep for PBMCs) for 16-18 h overnight. On the assay day, a frozen aliquot of CD20+ Raji tumor target cells (ATCC, Burkitt's lymphoma cell line) previously stained with a fluorescent encoder dye, was thawed, counted, and plated in triplicate in a 96 well plate at 20 K/well for 30 minutes at room temperature in the presence of individual anti-CD20 mAbs at concentrations ranging between 0- 10 µg/mL. The anti-hCD20 mAbs (InvivoGen) included hcd20-mab1 (Rtx-G1) composed of a human IgG1 Fc region and variable region of rituximab, hcd20ga-mab1 (Ob-G1) which was a fully humanized mAb with the variable region of obinutuzumab and a native human IgG1 Fc region, and hcd20ga-mab13 (Ob-G1nF) with the variable region of obinutuzumab and a nonfucosylated human IgG1 Fc region. Another anti-hCD20 mAb, hcd20ga-mab7 (Ob-A2), was used as a negative control. It also possessed the variable region of obinutuzumab, but had a human IgA2 constant region, and did not bind FcγRIIIa (CD16a). Next, effector cells were added at an Effector to Target (E:T) ratio of 10:1 (PBMCs) or 1:1 (enriched NK cells). In parallel, effector cells were cultured in triplicate in media alone, or cocultured with targets alone to evaluate direct tumor cell killing without antibody. Direct antibody-mediated killing of tumor cells was also assessed by culturing Raji cells with anti-CD20 mAbs in the absence of effector cells. Following co-culture for 4 hours at 37 °C, 5% CO2, 10 µL samples were assayed using the multiplexed iQue® Human NK Cell Killing Kit plus iQue® Human NK Companion Kits, and data acquisition was performed on the iQue® platform (VBR configuration) for advanced flow cytometry. Image Credit: Sartorius Figure 2. Illustration of iQue® Human NK Cell Killing Kit assay principles. Target cells are distinguished from effector cells by staining with a fluorescent encoder dye, and tumor cell killing is then determined by staining with a fluorescent cell membrane integrity dye. NK cells are identified using CD3, CD56, and CD16. Their activation state is assessed using CD69 and CD25. Production of the pro-inflammatory cytokine, Interferon gamma (IFNγ), and the pro-apoptotic serine protease, Granzyme B, are quantified using a 2-plex iQue Qbeads® in a sandwich immunoassay format in the same well. Additional compatible cytokines and effector proteins are measured by incorporating other iQue® Human NK Cell Companion Kits into the assay. Image Credit: Sartorius Figure 3. Comparison of the ADCC potency of two anti-hCD20 mAbs among three different donors. PBMCs (200K/well) from three separate donors were co-cultured in triplicate with encoded Raji tumor cells (20K/well) in the presence of different anti-hCD20 mAbs (Ob-G1, Rtx-G1, or Ob-A2, as a negative control). After 4h, 10 µL samples were transferred to assay plates and analyzed using the iQue® Human NK Cell Killing Kit plus iQue® Human NK Cell Companion Kits. (A) Dot plot showing separation of target cells from effector cells with the use of a fluorescent encoder dye. Target cell killing was then determined with the use of a cell membrane integrity dye to distinguish live and dead targets cells. (B) Percent dead targets displayed as a plate heat-map for Donor 1 over serial dilutions of 3 mAbs starting at 10 µg/mL. (C) EC50 curves showing percent tumor cell killing by effector cells from three donors tested in a second experiment with 3 mAbs over five-fold serial dilutions starting at 5 µg/mL. Raji cells were also incubated with the mAbs alone to evaluate direct Ab-mediated cytotoxicity (Targets alone). Image Credit: Sartorius Table 1. Comparison of mAb EC50 in relation to donor NK cell phenotype and FcγRIIIa genotype. Source: Sartorius Figure 4. Effector proteins and cytokines secreted during the PBMC- Raji tumor cell co-culture described in Figure 3C. Secretion levels of (A) Granzyme B and (B) IFNγ by PBMCs from Donor 1 cultured with Raji tumor cell in the presence of anti-hCD20 mAbs at concentrations ranging between 0–5 µg/mL. (C) Summary of cytokines produced by Donor 1 PBMCs co-cultured with Raji cells and 3 different mAbs at 1 µg/mL dose. Bar graph data presented as Mean +/- 1 SD, 3 replicates/mAb dose. () Significantly higher levels of cytokines produced in co-culture using ObG1 compared to Rtx-G1 anti-CD20 mAb, p < 0.05. Image Credit: Sartorius Figure 5. Secretion levels of (A) Granzyme B and (B) IFNγ by PBMCs from all 3 donors cultured with Raji tumor cells as described in Figure 3C at Ob-G1 concentrations ranging between 0–5 µg/mL. (C) Summary of cytokines produced by PBMCs from three donors co-cultured with Raji cells in the presence of Ob-G1 mAb at 1 µg/mL. Bar graph data presented as Mean +/- 1 SD, 3 replicates/mAb dose. () Significantly higher levels of cytokines produced by Donor 1 compared to Donor 2 or 3; p < 0.05. Image Credit: Sartorius Figure 6. The degree of NK cell-mediated ADCC and secretion levels of effector proteins were enhanced with the use of a non-fucosylated antiCD20 mAb (Ob-G1nF). Encoded Raji tumor cells (20K/well) were co-cultured with PBMCs (A, B, C) from Donor 3 at an E:T of 10:1, or enriched NK cells (D,E,F) from Donor 4 at an E:T of 1:1 in the presence of Ob-G1, Ob-G1nF, or Ob-A2 anti-hCD20 mAbs at concentrations ranging between 0–5 µg/mL. Both donors had a FcγRIIIa-158 F/F genotype. Percent tumor cell killing (A and D), and production of IFNγ (B and E) following coculture for 4 hours. (C and F) Summary of cytokines produced in the presence of 3 different mAbs at 1 µg/mL dose. Bar graph data presented as Mean +/− 1 SD, 3 replicates/mAb dose. (*) Significantly higher levels of cytokines produced in co-culture when using anti-CD20 mAb Ob-G1nF compared to Ob-G1, p < 0.05. Image Credit: Sartorius The iQue® Human NK Cell Killing Kit enabled the simultaneous determination of NK-mediated ADCC, expression of NK cell phenotypic markers, and estimation of IFNγ and Granzyme B, as well as the flexibility to quantify up to six additional effector proteins and cytokines using the iQue® Human NK Cell Companion Kits in the same well. The Ob-G1 anti-hCD20 mAb displayed improved ADCC potency compared to Rtx-G1 for all donors tested, according to the findings of this study. The use of the non-fucosylated anti-mAb, Ob-G1nF, with either PBMCs or enriched NK cells resulted in an even greater increase in ADCC and cytokine secretion. When the negative control anti-hCD20 mAb, Ob-A2, was added to the co-cultures, there was no increase in ADCC above baseline, and only very low levels of direct killing of Raji tumor cells were observed when the anti-hCD20 mAbs were used alone. Donor 1's PBMCs with a FcγRIIIa-158 V/V genotype had higher ADCC than Donor 2's (FcγRIIIa-158 V/F) or Donor 3's (FcγRIIIa-158 F/F) either using the Ob-G1 or Rtx-G1 anti-hCD20 mAbs. Furthermore, the levels of secretion of many effector proteins and cytokines mirrored the level of ADCC evoked by the various mAbs tested, and the variation in ADCC observed between donors. On the whole, this research revealed that using the iQue® Human NK Cell Killing Kit in combination with the iQue® Human NK Cell Companion Kits allows for a quick evaluation of the potency of various mAbs in ADCC mediated by NK cells, as well as a clear distinction between donors' mAb efficacy. Furthermore, analyzing NK-cell surface marker expression and cytokine secretion at the same time may reveal potential mechanistic distinctions that contribute to the differences in tumor cell killing noted between donors. With a short assay time of only 3.5 hours, the assay requires only 10 µl of sample and measures multiple endpoints from the same effector + target co-culture. The results could also be visualized right away, thanks to the iQue® platform and iQue Forecyt® software. As a result, the multiplexed iQue® Human NK Cell Killing Kit combines traditional workflows into a single assay platform, facilitating the creation and evaluation of new NK cell-related cancer immunotherapies. Sartorius is a leading international pharmaceutical and laboratory equipment supplier. With our innovative products and services, we are helping our customers across the entire globe to implement their complex and quality-critical biomanufacturing and laboratory processes reliably and economically. The Group companies are united under the roof of Sartorius AG, which is listed on the Frankfurt Stock Exchange and holds the majority stake in Sartorius Stedim Biotech S.A. Quoted on the Paris Stock Exchange, this subgroup is comprised mainly of the Bioprocess Solutions Division. A growing number of medications are biopharmaceuticals. These are produced using living cells in complex, lengthy and expensive procedures. The Bioprocess Solutions Division provides the essential products and technologies to accomplish this. In fact, Sartorius has been pioneering and setting the standards for single-use products that are currently used throughout all biopharmaceutical manufacturing processes. Lab work is complex and demanding: Despite repetitive analytical routines, lab staff must perform each step in a highly concentrated and careful way for accurate results. The Lab Products and Services Division helps lab personnel excel because its products, such as laboratory balances, pipettes and lab consumables, minimize human error, simplify workflows and reduce physical workloads Sponsored Content Policy: News-Medical.net publishes articles and related content that may be derived from sources where we have existing commercial relationships, provided such content adds value to the core editorial ethos of News-Medical.Net which is to educate and inform site visitors interested in medical research, science, medical devices and treatments. Last updated: Jun 9, 2023 at 7:19 AM Please use one of the following formats to cite this article in your essay, paper or report: Sartorius. (2023, June 09). Examining donor and antibody diversity with multiplex assays and flow cytometry. News-Medical. Retrieved on May 20, 2024 from https://www.news-medical.net/whitepaper/20220428/Examining-donor-and-antibody-diversity-with-multiplex-assays-and-flow-cytometry.aspx. Sartorius. "Examining donor and antibody diversity with multiplex assays and flow cytometry". News-Medical. 20 May 2024. <https://www.news-medical.net/whitepaper/20220428/Examining-donor-and-antibody-diversity-with-multiplex-assays-and-flow-cytometry.aspx>. Sartorius. "Examining donor and antibody diversity with multiplex assays and flow cytometry". News-Medical. https://www.news-medical.net/whitepaper/20220428/Examining-donor-and-antibody-diversity-with-multiplex-assays-and-flow-cytometry.aspx. (accessed May 20, 2024). Sartorius. 2023. Examining donor and antibody diversity with multiplex assays and flow cytometry. News-Medical, viewed 20 May 2024, https://www.news-medical.net/whitepaper/20220428/Examining-donor-and-antibody-diversity-with-multiplex-assays-and-flow-cytometry.aspx. 10 common applications of live cell analysis in immunology 3D Multi-Spheroid Live-Cell Assays Formed on Bio-Matrices 3D Organoid Growth in Matrigel® Domes: Real-Time, Live-Cell Analysis 3D Tumor Spheroid Invasion Monitoring with Live-Cell Analysis A Novel Way to Expedite Antibody Discovery with the Sartorius Mouse IgG Type and Titer Assay Kit A practical guide to selecting a mechanical pipette Accelerating biologics to market: The importance of GMP-compliant contract research organizations Advanced flow cytometry for next-level functional antibody analysis Advanced flow cytometry in infectious disease research Applying IncuCyte® Apoptosis Assay for the Fluorescent Detection of Caspase-3/7 Activation or Phosphatidylserine Externalization Assessing the function and phenotype of T-cells in a spheroid T-cell killing assay Cancer Drug Discovery Antibody Internalization Assays Cell morphology subpopulation classification in a label-free method Detecting Anti-SARS-CoV-2 antibodies through the use of flow cytometry Direct, Live-Cell Measurement of ATP via the Incucyte® ATP Assay Evaluation of Neuronal Cell Health using Quantitative, Real-Time Live-Cell Analysis Method and Reagents Fighting Disease with Developments to Stem Cell Research Fluorescent 96-Well Antibody Internalization Assays GPCR Targeting Monoclonal Antibodies: Using Them to Develop New Drugs How advanced flow cytometry could transform cell and gene therapy How Neuroscientists Can Use Live-Cell Analysis Immune Cells Killing 3D Tumor Spheroids in 96-Well Live-Cell Assay Improving HPLC sample preparation with the Cubis® MSA dosing system IncuCyte® Chemotaxis System for Directional Migration Assays Introducing real-time live-cell analysis with the Incucyte® Live-Cell Analysis System Kinetic Analysis of Microglial Function and Morphology Label-Free Real-Time Live-Cell Spheroid Assays Live-Cell Assays for Pharmacological Utility and Validation Long-Term Live-Cell Monitoring of Spontaneous Neuronal Activity Microbial air monitoring in clean room environments: Methods and issues Monitoring and Quantification of Cell Growth using IncuCyte Automated Live-Cell Analysis System Moving Research Forward Infographic - Incucyte® Publications Multi-Spheroid 3D Tumor Assays Development for Live-Cell Analysis Neuronal and Microglial Analysis for Alzheimer's Disease Models Opening Upstream Bottlenecks in Bioprocessing Bottlenecks with Analytical Power Tools Quantifying cell migration in real-time Quantitative Measurement of Cancer Cell Proliferation Using CellPlayer™ Kinetic Proliferation Assay Real Time Analysis of Advanced Cell Models eBook Real Time Measurement of Tumor Cell Death Using IncuCyte® Immune Cell Killing Assay Real-Time Live-Cell Imaging and Analysis Handbook Real-Time, Automated Cellular Phagocytosis and Efferocytosis Assays Inside a Cell Culture Incubator Real-Time, Automated Cytotoxicity Assays within a Tissue Culture Incubator Real-Time, Long-Term Quantitative Analysis of iPSC-Derived Neuronal Cell Health Sartorius Advanced Cell Model Assay Application Posters Simplifying iPSC Work Flow with IncuCyte Live Content Imaging System Simultaneous Measurement of T-Cell Activation via Proliferation, Cytokine Secretion and Differentiation The best methods to avoid contamination in pipetting The necessity of ultrapure water in cell culture Tracking Cell Surface Markers and Cell Populations with Live-Cell Analysis Training Video: From Culture to Assay, Live-Cell Analysis Understanding and analyzing T Cell exhaustion Understanding small molecule transport across cell membranes Using bead-based, high throughput panels to improve the quality of T helper cell cytokine profiling Using Continuous Live-Cell Analysis to Meet New Requirements of Cellular Research Using IncuCyte for Automatic Quantification of Live Cell Analysis Using Multiplexed Screening for Advanced Therapeutic Antibody Discovery Utilizing live-cell analysis to characterize astrocyte models Validation of NeuroTrack Assay for Medium-Throughput Testing in 96-Well Format Visualizing and Quantifying Long-Term Live-Cell Neuronal Activity Why ultrapure water is critical for HPLC analysis Your AI Powered Scientific Assistant Hi, I'm Azthena, you can trust me to find commercial scientific answers from News-Medical.net. A few things you need to know before we start. Please read and accept to continue. Great. Ask your question. While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided. Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles. Please do not ask questions that use sensitive or confidential information. Read the full Terms & Conditions. Provide Feedback
How to Lower Cholesterol, According to a Cardiologist and Sports Dietitian Some cyclists might assume they have normal cholesterol levels because they ride many miles each week or follow a plant-based diet. But heart health relies on more than just aerobic fitness or going meatless, and getting your cholesterol levels tested is key to understanding what's going on inside your body in terms of overall health. Cholesterol is one of the most commonly misunderstood and complex topics when discussing general health, and while aerobic exercise does help to lower cholesterol and protect your heart, cycling on its own isn't always enough to keep high cholesterol at bay. For more facts on this health marker, we spoke with a cardiologist and a sports dietitian who also explain how to lower cholesterol. What is cholesterol? Michael Barber, M.D., Ph.D., a board-certified cardiologist and Medical Director at Strata Integrated Wellness in Colorado Springs, describes cholesterol as a naturally occurring, waxy substance that's found in the blood—and it's not necessarily bad unless you have too much of it. "You need cholesterol to build healthy cells," says Barber. "It's involved in building the structure around the nervous system and the structure of blood vessels throughout the body, among other things." The two types of cholesterol are referred to as HDL (high-density lipoprotein) and LDL (low-density lipoprotein). LDL is referred to as "bad cholesterol" because it contributes to fatty buildup in arteries which can lead to heart disease, while HDL, the "good cholesterol," has good protective qualities, helping to remove LDL from our system and back into the liver where it can be broken down and excreted. The liver is where blood cholesterol is created and sent throughout the body to make cell membranes, vitamin D, and many of our hormones. A secondary source of cholesterol, dietary cholesterol, comes from the food that you consume. While eggs are often depicted as public enemy number-one, foods high in saturated fat—fatty cuts of red meat, butter, skin on poultry, and palm oil—as a few examples—may be more likely to elevate LDL levels, explains Nicole Rubenstein, RD, certified sports dietitian and owner of Racer's Edge Nutrition. Rubenstein acknowledges that there are continuing studies on whether or not saturated fat should necessarily be labeled "bad," but experts note the correlation between excessive saturated fat intake and elevated LDL, including the American Heart Association. Rubenstein also notes that every person is a unique case, and genes may be more of a factor than diet; when a client's lipid panel shows elevated cholesterol, Rubenstein examines the bigger picture before creating a nutrition plan. "I always take a look at their medical history and family history, because sometimes an active person has familial hypercholesterolemia [a.k.a. high cholesterol]—so it could be genes predisposing them," she says. What are considered healthy cholesterol numbers versus high cholesterol numbers? When you get blood drawn for a basic lipid panel, you'll find your total cholesterol, which is a measurement of the levels of HDL, LDL, and triglycerides in your blood. A total cholesterol of less than 200 is considered healthy, while a number in the 200 to 240 range is approaching borderline high levels and indicates the need for diet and exercise modifications. Any number over 240 is considered high cholesterol ("hypercholesterolemia") and will likely require a prompt treatment plan that may include medication. Why is high cholesterol bad? Barber explains that high levels of cholesterol, particularly LDL cholesterol, will get deposited in the arteries and cause fatty buildup, commonly termed "atherosclerosis." High cholesterol in itself does not necessarily come with an immediate batch of signs and symptoms, but if left to progress over time, it can become a serious health threat. "Fatty buildup compromises an artery's flow," Barber says. "In the carotid arteries [which provide your brain's blood supply], this can cause stroke, in the heart arteries, this can cause a heart attack, in the aorta or the lower extremity arteries it can cause a blood flow decrease to the lower extremities."
A sportsbook is an establishment that accepts wagers on a variety of sporting events. The days of physically visiting a betting outlet are long gone; instead, bettors can place their wagers from the comfort of home or on-the-go with online sportsbooks. These sites offer a variety of betting options from classic horse racing to America's most popular pro and college sports. Sportsbooks set their odds based on an analysis of the event's outcome. They then take a small commission on winning bets. In addition, they also charge fees for handling bets and maintaining their accounts. These fees vary depending on the sport and the level of competition. When it comes to winning at sports betting, there is no magic formula. It takes discipline, research, and a solid understanding of the rules of each sport. It's also important to keep track of bets and losses on a spreadsheet. Lastly, it's critical to know your limits and stick to them. In addition, you should always bet on a team that you are familiar with from a rule standpoint and follow news about injuries or roster changes. The astute sports bettor is interested in the probability that a wager against the spread will yield a positive expected profit. This probability is estimated by evaluating the distribution of the margin of victory over the proposed sportsbook odds. The empirical CDF is evaluated for offsets of 1, 2, and 3 points from the true median result. The results are compared with the theoretical optimal, and the expected profit on a unit bet is computed. In a perfect world, the bettor would be able to make wagers with confidence that the sportsbook's proposed margin of victory estimate was accurate. However, in practice the underlying distribution of this variable is not normally distributed. To assess this, a distribution-based test was developed to measure how well the sportsbook captured the median margin of victory. Whether it's for football, basketball, baseball or hockey, odds are constantly being updated at sportsbooks. These odds are adjusted based on public action, injury reports, coaching changes, and other relevant information. Keeping a close eye on these odds can help you avoid making mistakes and maximize your profits. Another way to increase your chances of winning is to find a reputable sportsbook that offers multiple payment methods. This includes debit and credit cards, wire transfers, and eWallets. It's also a good idea to look for sportsbooks that process payments quickly and efficiently. When it comes to sportsbooks, layoff accounts are a great way to balance bets and minimize financial risks. Many online sportsbook management software vendors offer this feature, which can be used to prevent bets from going down when a game is not going in your favor. This can save you money and lower your risk by allowing you to hedge bets and protect your profits.
We all have habits that help us organize our lives and develop useful skills. However, there are habits over which we lose control, leading to a psychological dependence — addictions — on them. Psychological dependence (or simply called addictions) on nicotine, alcohol, drugs, games and others refers to a strong, irresistible attraction to a person, object, phenomenon, or action. Anyone, regardless of gender or age, can develop addictions. Essentially, addictions are our habits, our tendencies to repeat the same actions. In mild forms, they may not inconvenience us; they may even benefit us, such as playing sports or reading. But what is the core of addiction? The problem of addiction isn't just about lacking willpower; it involves two factors: chemical and psychological. The chemical aspect relates to blood and body intoxication, while the psychological aspect revolves around dopamine release, the pleasure hormone. Engaging in addictive activities triggers dopamine release, leading to satisfaction. Over time, the brain craves more dopamine, reinforcing addiction through this psychological mechanism. Another example is gambling addiction, where individuals experience a release of adrenaline during gameplay, and upon winning, they receive a surge of dopamine. In the most severe cases, those with addictive personalities lose touch with reality and become genuinely dangerous to themselves and society. Seeking help from a specialist is the best solution in combating addiction in its later stages. However, in the early phases of forming a bad habit, relying on willpower and working on cravings and withdrawal symptoms may suffice. Today, the supplement market offers various solutions to support the fight against addiction and bad habits. We spoke with Vyacheslav Rastashansky, founder and head of the development team of Normotim, which offers a unique lithium ascorbate compound designed to assist in addiction treatment and recovery. Lithium Ascorbate helps addiction treatment and recovery by reducing cravings and balancing neurotransmitters. By modulating brain chemicals associated with the urge to use substances, which promotes the balance of neurotransmitters such as dopamine and serotonin, and contributes to mood stabilization and overall well-being. Its support for detox processes aids in clearing the body of harmful substances, facilitating a smoother transition to a sober lifestyle. Vyacheslav highlights that Normotim's Lithium Ascorbate offers significant benefits in treatment. Managing these cravings and symptoms is crucial for a successful recovery journey. Targeting neurotransmitter pathways, Lithium Ascorbate helps individuals cope with withdrawal discomfort, decreasing the intensity of cravings and facilitating resistance against relapse urges. When combined with therapy and other coping strategies, Lithium Ascorbate becomes a valuable support tool for individuals in their recovery process. Powerful formula of lithium and vitamin C Lithium Ascorbate blends lithium, a mineral with neuroprotective qualities, and ascorbate, a type of Vitamin C. Often used in alternative medicine, it's valued for potential mental and brain health benefits. This unique combination offers a range of advantages for overall well-being and brain function. Lithium is known for supporting healthy brain function and mood regulation, while ascorbate enhances its antioxidant properties, shielding brain cells from stress and inflammation. Together, lithium and ascorbate in Normotim's Lithium Ascorbate provide a holistic approach to improving cognitive function, mental well-being, and fighting bad habits and addictions. How does Normotim really work It literally blocks the release of dopamine when a psychoactive substance (or action) is taken. This prevents the addict from experiencing satisfaction, gradually reducing psychological dependence on the substance or action. Here is a simple example — Imagine yourself at point A, where you currently smoke, and you're using Normotim's lithium ascorbate to reach point B, where you're free from addiction. Lithium ascorbate works by changing how your brain responds to substances. It helps reduce the release of feel-good chemicals like endorphins and rewires the brain's reward system. By doing this, it makes it easier to break free from the psychological dependence on substances, offering hope for addiction treatment. Normotim, with its lithium ascorbate formula, has become crucial for many fighting bad habits like smoking, drinking and consuming sugar. It's not just about kicking a habit; it's about embracing a life with more energy, clarity, and happiness. How To Take Normotim Lithium Ascorbate The recommended dosage varies depending on individual needs and health conditions. It's crucial for supporting brain performance, optimizing brain health, and supplementing lithium for overall well-being. Factors like age, weight, existing medical conditions, and dietary habits should be considered when determining the right dosage. Consulting with a healthcare provider is recommended to check these factors and customize the dosage to meet specific requirements. To learn more about Normotim lithium ascorbate, visit our website. The Editorial Team at Healthcare Business Today is made up of skilled healthcare writers and experts, led by our managing editor, Daniel Casciato, who has over 25 years of experience in healthcare writing. Since 1998, we have produced compelling and informative content for numerous publications, establishing ourselves as a trusted resource for health and wellness information. We offer readers access to fresh health, medicine, science, and technology developments and the latest in patient news, emphasizing how these developments affect our lives.
By clicking "Check Writers' Offers", you agree to our terms of service and privacy policy. We'll occasionally send you promo and account related email No need to pay just yet! About this sample About this sample Words: 785 \| Pages: 2\| 4 min read Published: Mar 14, 2024 Words: 785\|Pages: 2\|4 min read Published: Mar 14, 2024 The Salem Witch Trials of 1692 have long captured the imagination of scholars and the public alike, serving as a cautionary tale of mass hysteria, fear, and injustice. From accusations of witchcraft to the executions of innocent individuals, this dark chapter in American history continues to fascinate and provoke debate. In this essay, we will delve into the complexities of the Salem Witch Trials through a document-based question (DBQ) analysis, exploring the various factors that contributed to this tragic episode. By examining primary sources and historical evidence, we will seek to understand the social, political, and religious dynamics that fueled the witch hunts in colonial Massachusetts. Our thesis statement asserts that the Salem Witch Trials were a result of a combination of religious fervor, social tensions, and political opportunism, ultimately leading to the unjust persecution of numerous individuals. Through a close examination of the documents at hand, we aim to shed light on the underlying causes and consequences of this infamous event. Join us on this journey as we unravel the mysteries of the Salem Witch Trials and uncover the truths hidden within the shadows of history. The Salem Witch Trials were a complex and multifaceted event that was influenced by various factors. One of the key elements that contributed to the hysteria was the deeply ingrained religious beliefs of the Puritan community in colonial Massachusetts. The Puritans viewed the world through a lens of good versus evil, with a strong emphasis on spiritual purity and adherence to strict moral codes. This religious fervor created a fertile ground for suspicion and paranoia, as any deviation from the established norms was seen as a sign of witchcraft. For example, in the case of Tituba, a slave woman accused of witchcraft, her involvement in voodoo practices and unfamiliar cultural beliefs made her a prime target for accusations. The religious zeal of the Puritans, combined with their fear of the unknown and the supernatural, fueled the witch hunts and led to the unjust persecution of innocent individuals. In addition to religious factors, social tensions also played a significant role in the Salem Witch Trials. The small and insular community of Salem Village was rife with interpersonal conflicts, rivalries, and power struggles that simmered beneath the surface. The accusations of witchcraft provided an outlet for settling scores and asserting dominance, as individuals used the hysteria to target their enemies and eliminate competition. For instance, the Putnam family, a prominent and influential clan in Salem Village, used the trials to advance their own agenda and consolidate their power. By accusing their rivals of witchcraft, they not only eliminated potential threats but also gained social status and influence within the community. The social dynamics of Salem Village, characterized by distrust, envy, and resentment, exacerbated the witch hunts and led to a climate of fear and suspicion. Moreover, political opportunism further fueled the Salem Witch Trials, as local officials and leaders exploited the hysteria for their own gain. The colonial government, led by Governor William Phips, saw an opportunity to assert control and demonstrate their authority by cracking down on supposed witches. The trials provided a distraction from ongoing political unrest and economic instability, allowing the government to divert attention away from pressing issues and rally public support. In exchange for their cooperation in the witch hunts, local officials were rewarded with power, prestige, and influence. For example, Judge Samuel Sewall, one of the presiding magistrates in the trials, used his position to enhance his standing in the community and curry favor with the colonial authorities. The political machinations behind the scenes of the Salem Witch Trials revealed a darker side to the pursuit of justice, as individuals in positions of power exploited the hysteria for personal gain. In conclusion, the Salem Witch Trials were a tragic event fueled by religious fervor, social tensions, and political opportunism. The Puritan community's strict beliefs in good versus evil, combined with interpersonal conflicts and power struggles in Salem Village, created a breeding ground for suspicion and paranoia. Political leaders, such as Governor William Phips and Judge Samuel Sewall, capitalized on the hysteria to assert control and gain personal advantages. The lessons learned from the Salem Witch Trials remind us of the dangers of prejudice, unchecked power, and fear-mongering. As we reflect on this dark chapter in American history, let us strive to uphold principles of justice, fairness, and compassion in our own lives and communities. Moving forward, further research into the Salem Witch Trials can shed light on the complexities of this event and its lasting impact on society. By uncovering the truths hidden within the shadows of history, we can continue to learn from the mistakes of the past and work towards a more just and equitable future. Browse our vast selection of original essay samples, each expertly formatted and styled
Greetings, flower enthusiasts! Welcome to this captivating photographic tour of the Cotswolds and its enchanting seasonal flower shows. The Cotswolds, located in south-central England, is renowned for its picturesque landscapes, charming villages, and vibrant floral displays. In this article, we will delve into the beauty of the Cotswolds' flower shows, showcasing their unique charm and capturing their essence through stunning photographs. Join us as we embark on a visual journey through the Cotswolds' seasonal flower shows, capturing the magic and splendor of nature's breathtaking creations. Discovering the Cotswolds 🌸 Nestled in the heart of England, the Cotswolds is a region of extraordinary beauty. With its rolling hills, idyllic villages, and stunning natural landscapes, it has long been a magnet for nature lovers and photographers alike. The Cotswolds' flower shows offer a unique opportunity to experience the region's rich horticultural heritage and immerse oneself in the beauty of its seasonal blooms. 🌺 The Cotswolds is known for its quintessentially English charm, with honey-colored stone cottages, historic churches, and quaint market towns dotting the landscape. It is a place where time seems to stand still, and where nature's beauty is celebrated in every corner. The flower shows of the Cotswolds embody this spirit, showcasing the region's natural bounty and providing a platform for gardeners, enthusiasts, and visitors to come together and revel in the glory of flowers. The Beauty of the Cotswolds' Flower Shows 🌼 Immerse yourself in a world of vibrant colors, delicate fragrances, and stunning floral arrangements as you explore the Cotswolds' flower shows. These shows are a celebration of nature's beauty, showcasing a wide variety of flowers and plants that thrive in this idyllic region. From the iconic English roses to exotic orchids, the flower shows offer a feast for the senses, captivating visitors with their exquisite displays. 🌷 One of the highlights of the Cotswolds' flower shows is the breathtaking display of seasonal blooms. Each season brings its own unique charm, with spring showcasing a vibrant array of tulips, daffodils, and cherry blossoms, while summer bursts with the colors of roses, peonies, and lavender. Autumn delights visitors with a tapestry of golden leaves, chrysanthemums, and dahlias, while winter enchants with its delicate snowdrops and hellebores. Exploring the Cotswolds' Flower Shows 🌹 As you wander through the Cotswolds' flower shows, you'll be transported to a world of beauty and wonder. The shows are carefully curated, with each display thoughtfully designed to create a harmonious and visually stunning experience. From grand floral arches to intricately arranged bouquets, every corner of the flower shows is a testament to the artistry and creativity of the exhibitors. 🌻 Beyond the flowers themselves, the Cotswolds' flower shows provide an opportunity to immerse oneself in the region's rich history and culture. Many of the shows are held in historic venues, such as stately homes or gardens with centuries-old heritage. As you wander through the displays, you can't help but feel a sense of connection to the past, imagining the generations of gardeners who have lovingly tended to these landscapes. Learning and Growing at the Cotswolds' Flower Shows 🌸 The Cotswolds' flower shows are not just a treat for the eyes; they also provide valuable educational opportunities. Many shows offer talks and workshops by gardening experts, providing insights into various aspects of horticulture. Whether you are a seasoned gardener looking to expand your knowledge or a novice seeking inspiration, the Cotswolds' flower shows offer a wealth of information and expertise. 🌺 Another highlight of the Cotswolds' flower shows is the opportunity to browse and purchase a wide variety of plants, gardening tools, and accessories. From rare and exotic plants to traditional English garden favorites, you can find it all at these shows. Whether you are looking to enhance your own garden or find the perfect gift for a fellow flower enthusiast, the Cotswolds' flower shows are a treasure trove of gardening delights. Table: Cotswolds' Flower Shows Information Flower Show \| Date \| Location \| Highlights \| Spring Spectacular \| April 10-12 \| Chipping Campden \| Tulip displays, gardening workshops, children's activities \| Roses & Romance \| June 19-21 \| Bourton-on-the-Water \| Rose garden tours, live music, afternoon tea \| Autumn Harvest \| September 25-27 \| Broadway \| Pumpkin displays, apple tasting, scarecrow competition \| Winter Wonderland \| December 4-6 \| Stow-on-the-Wold \| Festive floral arrangements, Christmas market, carol singing \| FAQ: Frequently Asked Questions 1. Can I bring my pet to the flower shows? 🐾 Yes, many of the Cotswolds' flower shows are pet-friendly. However, it is advisable to check the specific show's guidelines before bringing your furry friend along. 2. Are the flower shows wheelchair accessible? ♿ Yes, the organizers strive to make the flower shows accessible to all visitors. Most venues have wheelchair ramps and accessible facilities. If you have specific accessibility requirements, it is recommended to contact the show organizers in advance. 3. Are the flower shows suitable for children? 👶 Absolutely! The flower shows offer a range of activities and entertainment for children, making them a perfect day out for the whole family. From face painting to craft workshops, there is something to keep children of all ages engaged and entertained. 4. Can I buy plants at the flower shows? 🌱 Yes, the flower shows have a wide selection of plants available for purchase. From popular garden favorites to rare and exotic species, you are sure to find something to suit your taste and garden space. 5. Can I enter my own flower arrangement in the competitions? 🏆 Yes, many of the flower shows encourage visitors to participate in their competitions. Whether you have a flair for floral design or simply want to showcase your gardening skills, entering your own flower arrangement can be a rewarding and fun experience. 6. Are there food and refreshments available at the flower shows? 🍽️ Yes, the flower shows typically have a range of food stalls and refreshment stands offering a variety of delicious treats. From traditional British fare to international cuisines, you can satisfy your appetite while enjoying the beautiful surroundings. 7. Can I get gardening advice at the flower shows? 🌿 Absolutely! The flower shows often feature talks and workshops by gardening experts, providing invaluable advice and insights. Whether you are a beginner or an experienced gardener, you can learn new techniques and gain inspiration from these knowledgeable experts. Cotswolds: Where Beauty Blooms 🌸 The Cotswolds' flower shows are not just events; they are experiences that will stay with you long after the petals have faded. So, seize the moment, embrace the beauty, and let the Cotswolds' seasonal flower shows ignite your passion for all things floral. 🌺 So, what are you waiting for? Start planning your visit to the Cotswolds' flower shows today and experience the magic for yourself. Whether you're a passionate gardener, a photography enthusiast, or simply someone who appreciates the beauty of nature, the Cotswolds' flower shows are sure to leave a lasting impression. Don't miss out on this extraordinary opportunity to witness the splendor of the Cotswolds' seasonal flower shows. 🌼 Remember, the Cotswolds' flower shows are not just about the flowers; they are about celebrating the connection between nature, culture, and the human spirit. They are a testament to the power of beauty and the importance of preserving our natural heritage. 🌷 So, pack your camera, put on your walking shoes, and get ready to be mesmerized by the Cotswolds' seasonal flower shows. Immerse yourself in the vibrant colors, delicate fragrances, and captivating beauty of these floral wonders. And remember, the Cotswolds' flower shows are more than just a sight to behold – they are an invitation to connect with nature and find inspiration in the simple yet profound beauty of flowers. 🌹 Your journey awaits, and the Cotswolds' flowers are ready to enchant you. So, go ahead, explore, discover, and let the beauty of the Cotswolds' flower shows awaken your senses and nourish your soul. The information provided in this article is based on research and personal experiences and is intended for general informational purposes only. The author and publisher assume no responsibility for any actions taken by individuals based on the information provided. 🌸 The Cotswolds' flower shows mentioned in this article may have specific guidelines and restrictions due to various factors, including weather conditions and venue regulations. It is advisable to check the official websites or contact the respective show organizers for the most up-to-date information and details. 🌺 The photographs featured in this article are for illustrative purposes only and may not necessarily represent the exact displays or venues mentioned. The beauty of the Cotswolds' flower shows is best experienced in person. 🌼 The author and publisher do not endorse any specific flower show or organization mentioned in this article. The information provided is solely for informational purposes, and individuals should exercise their own discretion and judgment when attending or participating in any flower show. 🌷 The author and publisher are not responsible for any errors or omissions in the information provided in this article. The content is provided on an "as is" basis and is subject to change without notice. 🌹 In no event shall the author or publisher be liable for any damages, losses, or injuries arising from the use of the information provided in this article. 🌻 All trademarks and copyrights mentioned in this article belong to their respective owners and are used for informational purposes only.
Host specificity of Metriona elatior, a potential biological control agent of tropical soda apple, Solanum viarum, in the USA dc.contributor.author \| Medal, J. C. \| \| dc.contributor.author \| Pitelli, R. A. [UNESP] \| \| dc.contributor.author \| Santana, A. [UNESP] \| \| dc.contributor.author \| Gandolfo, D. \| \| dc.contributor.author \| Gravena, R. [UNESP] \| \| dc.contributor.author \| Habeck, D. H. \| \| dc.contributor.institution \| Dept. of Entomology and Nematology \| \| dc.contributor.institution \| Universidade Estadual Paulista (UNESP) \| \| dc.contributor.institution \| USDA-ARS S. Amer. Biol. Contr. Lab. \| \| dc.date.accessioned \| 2022-04-29T08:46:49Z \| \| dc.date.available \| 2022-04-29T08:46:49Z \| \| dc.date.issued \| 1999-12-01 \| \| dc.description.abstract \| The leaf beetle Metriona elatior from Brazil-Argentina was screened in the Florida (USA) State quarantine facility as a potential biological control agent of tropical soda apple, Solanum viarum, a recently arrived weed species. Multiple-choice host-specificity tests were conducted in small cages (60 cm × 60 cm × 60 cm) using 95 plant species in 29 families. Adults fed heavily on the main target weed (S. viarum), and on turkeyberry, Solanum torvum (noxious weed of Asiatic origin); fed moderately on red soda apple, Solanum capsicoides (weed of South American origin), and eggplant, Solanum melongena (economic crop); and fed lightly on aquatic soda apple, Solanum tampicense (weed of Mexican-Caribbean-Central American origin), and on silverleaf nightshade, Solanum elaeagnifolium (native weed widely distributed). M. elatior adults laid 84 to 97% of their egg masses on S. viarum, and 3 to 16% on S. melongena. Non-choice host-specificity tests were also conducted in quarantine in which M. elatior adults and neonate larvae were exposed to 17 and 19 plant species, respectively. Tests with the neonates indicate that this insect was able to complete its development on S. viarum, S. torvum, S. melongena, and S. capsicoides. Although some adult feeding and oviposition occurred on S. melongena in quarantine on potted plants in small cages, no feeding or oviposition by M. elatior was observed in field experiments conducted in Brazil. Surveys in unsprayed S. melongena fields in Argentina and Brazil indicated that M. elatior is not a pest of S. melongena in South America. The evidence obtained from the South-American field surveys, Brazil open-field experiments, and Florida quarantine host specificity tests indicate that M. elatior causes significant feeding damage to S. viarum, and does not represent a threat to S. melongena crops in the USA. Therefore an application for permission to release M. elatior against S. viarum in the USA was submitted in October 1998. \| en \| dc.description.affiliation \| University of Florida Dept. of Entomology and Nematology, Gainesville, FL 32611 \| \| dc.description.affiliation \| Universidade Estadual Paulista, Jaboticabal, Sâo Paulo State \| \| dc.description.affiliation \| USDA-ARS S. Amer. Biol. Contr. Lab., Hurlingham \| \| dc.description.affiliationUnesp \| Universidade Estadual Paulista, Jaboticabal, Sâo Paulo State \| \| dc.format.extent \| 421-436 \| \| dc.identifier.citation \| BioControl, v. 44, n. 4, p. 421-436, 1999. \| \| dc.identifier.issn \| 1386-6141 \| \| dc.identifier.scopus \| 2-s2.0-0001409304 \| \| dc.identifier.uri \| http://hdl.handle.net/11449/231656 \| \| dc.language.iso \| eng \| \| dc.relation.ispartof \| BioControl \| \| dc.source \| Scopus \| \| dc.subject \| Classical biological control \| \| dc.subject \| Solanaceae \| \| dc.title \| Host specificity of Metriona elatior, a potential biological control agent of tropical soda apple, Solanum viarum, in the USA \| en \| dc.type \| Artigo \|
The Master of Science Programme in "Sustainable Agro-ecosystems and Resilience (SARe)" provides a two-year curriculum and is an innovative educational path that aims at preparing professionals to tackle the complex challenges to sustain food production in rural areas. The Master course focuses on farming and food systems evolution, identifying 1) the agro-ecosystem as the unit for action, a complex system with economic, social, and ecological components; 2) the local community as the main stakeholder relying on the agroecosystem functions and aiming to conserve and improve its ability to resist and respond to changes. Agro-ecosystems will be studied as farm and landscape systems delivering important services to societies, and that evolve in relations with agri-food policies and people's behaviours. Solutions are proposed for their sustainable management with focuses on biodiversity, water, and soil resources, and in the frame of climate change. Attention is given to how to promote, at local level, stakeholders' participation and empowerment in agro-ecosystem planning and management, and on ways to establish agri-food networks driven by green and ethical principles, and for an agro-ecological transition. The course presents methodologies and tools for assessment and diagnosis of agroecosystem sustainability and community resilience, and how to design and implement projects for sustainable development of agri-food sector and communities.
Barnett, Anthony (2014) Categorising Asynchronous Discussion Threads: Improving the Quality of Student Learning. In: Higher Education Academy Annual Conference, 2nd-3rd July 2014, Aston University, Birmingham. (Unpublished) HEA conference poster 2014.pdf Download (1MB) \| Preview \| Short abstract Blended learning approaches incorporate the value of both face-to-face teaching sessions and distance learning. The generative potential of asynchronous discussion thread categorisation is being utilised to engage students in a reflective process aimed at improving the quality of their learning experience. Details of the poster: The poster will present the follow up study to the original research that was conducted in 2011 and reported in the Worcester Journal of Learning and Teaching entitled 'Blended learning: Evaluation of the WebCT Blackboard virtual learning environment in relation to asynchronous discussion and student assignments.' The poster will include a background to this small scale research. A main feature of the poster will be the visual display of a range of models of asynchronous discussion threads and associated interpretations. Problems addressed: Visual representation of more complex discussion threads has been approached through colour coding within both linear and aggregated views. Research issues: The main research issue confronted in the initial 2011 study was the need to combine both quantitative and qualitative data within a predominantly generative format. Similarly, the current research aims to be a foundation for students developing their own strategies as part of a blended learning module. The data therefore needs to be presented in a way that is both accessible and evocative. Research methods: The data included posted messages to the online asynchronous discussion within a blended learning module; the results of a questionnaire relating to the students' use of the star rating feature within Blackboard and; student assignments in which students evaluated their contribution to the asynchronous discussion and use of the VLE. The approach to categorising discussion threads was a qualitative adaptation of the social network analysis reported by Jimoyannis & Angelaina (2012 in the Journal of Computer Assisted Learning. Preliminary findings: • A range of models describing the asynchronous discussion threads have been identified and given the following labels: passive facilitator, dominant facilitator, multiple facilitators discussion, balanced discussion, cliqued discussion, formulaic discussion, self-referencing discussion, multiple sub-threads discussion. • One of the findings related to the questionnaire: Although students used a wider range of criteria for allocating star ratings, these criteria typically related to various dimensions of added value. • In relation to the student assignments: One of the findings is that many of the students have used Bloom's digital taxonomy rubric to influence their approach to posting messages. This was to be expected as the previous 2011 research study was discussed within the module. Assignments have also shown students using alternative theoretical perspectives to support their analysis. Conference theme links: Blended learning approaches relate directly to the strand 'The future is connected' because of being a form of technology enhanced learning. Item Type: \| Conference or Workshop Item (Poster) \| Uncontrolled Discrete Keywords: \| asynchronous, discussion, blended learning \| Subjects: \| H Social Sciences > H Social Sciences (General) L Education > L Education (General) \| Divisions: \| College of Arts, Humanities and Education > School of Education \| Related URLs: \| \| Copyright Info: \| Anthony Barnett \| Depositing User: \| Anthony Barnett \| Date Deposited: \| 28 Jul 2014 14:15 \| Last Modified: \| 17 Jun 2020 17:04 \| URI: \| https://eprints.worc.ac.uk/id/eprint/3293 \| Actions (login required) View Item \|
Dr. Myriam Fernández Martín is a Healthcare Executive and PhD Nurse with more than 20 years of experience in the intersection between healthcare and IT: 12 in Europe and 9 in the USA. She is recognized in the industry as a visionary executive and trusted C-Suite advisor, with a proven track record accelerating healthcare digital transformation. As the Head of Health Innovation for EMEA (Europe, Middle East and Africa), Dr Fernández is responsible to guide the AWS clients and partners on how to leverage the breadth and depth of AWS cloud services to deliver personalized health in their outcomes-oriented strategies. She has been recently named Most Admired Woman in Digital Health to follow in 2024. Recently, in an exclusive interview with Digital First Magazine, Dr. Myriam Fernández shared her professional trajectory, insights on the biggest opportunities and obstacles for innovation in the healthcare environment, the best piece of advice she has ever received, the secret mantra behind her success, future plans, pearls of wisdom, and much more. The following excerpts are taken from the interview. Hi Dr Myriam Fernández. Please tell us about your background and areas of expertise. Clinically grounded, I am a registered nurse, I hold a PhD in Health Sciences and Master in Science of Nursing by the University of Alicante and an Executive Certificate in Healthcare Leadership by the University of Missouri. After spending several years working as a nurse in different positions in hospitals in Spain, I embarked quickly in the intersection of healthcare and IT, first in Spain, with a local healthcare IT company called IT Deusto, and later with Cerner Corporation (now Oracle Health) as the first Spanish associate to join the company in Spain. In this role I expanded my responsibilities across Europe, driving the clinical transformation teams and standing up a strategic growth portfolio. Due to my demonstrated leadership and achievement of results on high speed to growth and profit, I was then asked to relocate to the US in 2013 to stand up the Value Advisory team as a Senior Director with Cerner Corporation. Overall, I had the privilege to work with more than two hundred C-suites worldwide. In 2022, I came back to Europe as the Head of Health Innovation for Amazon Web Services (AWS) for the EMEA region. I am now responsible to guide the AWS clients and partners on how to leverage the breadth and depth of AWS cloud solutions to deliver personalized health and care in their outcomes-oriented strategies. Applying continuous improvement methods, I advise leaders in making their healthcare digital transformation programs become mechanisms that improve health, operational and financial outcomes. What is your most favorite aspect of your current role? Healthcare is facing unprecedented challenges and healthcare organizations, governments, payors, healthcare techs as well as startups are looking for innovative ways to overcome them. We live longer with more chronic conditions and there is a need and demand for personalized care. Meanwhile, the costs of healthcare continue to rise, the healthcare systems are based on volume rather than value, nearly half of clinical professionals are suffering burnout[1], patient safety remains a challenge and, inequities in health and care continue to grow. All of these, combined with the fact that the healthcare data volume doubles every two years but 97% of goes unused because it is trapped in unstructured formats[2], and that healthcare organizations are a target for cyberattacks, with a growth year over year of 60% of this threat[3], makes the journey to cloud enabled advanced services a key cornerstone for any sustainable, resilient healthcare system strategy. At AWS we are committed to providing technology that empowers healthcare organizations to deliver high quality, equitable care, and championing the use of our services to elevate the human condition. In my day to day, I have the responsibility to shape the healthcare strategy across the region, guiding AWS clients and partners on how to leverage the breadth and depth of AWS cloud solutions to deliver personalized health and care in their outcomes-oriented initiatives. I am particularly focused on innovation, generative artificial intelligence (generative AI) and continuous improvement methods. To deliver the services consumers expect, organizations, from providers and payors to healthtechs, need to innovate faster and unlock the potential of data, all while keeping health information secure and private. AWS empowers health organizations to improve outcomes and accelerate the digitalization and utilization of their data with the broadest and deepest portfolio of cloud services, purpose-built industry solutions, and an extensive partner network. This commitment to healthcare was further solidified almost a decade ago when AWS created a dedicated Healthcare and Life Sciences (HCLS) team consisting of healthcare professionals, industry experts, and cloud experts to help create solutions designed specifically for Healthcare's unique needs. Since then, the AWS HCLS team has collaborated with health organizations across the globe to design and deploy solutions with a unified goal in mind: improving healthcare outcomes while giving customers control over their healthcare IT delivery costs. AWS' scale, computing power, resiliency, deep expertise in healthcare, and portfolio of purpose-built services has established AWS as the trusted technology and innovation partner to the global health industry. I love being part of enabling a positive change in healthcare on using technology for good. Looking more broadly, what are the biggest opportunities and obstacles you see for innovation in the healthcare environment? Healthcare is a discipline with innovation tied to its core. Clinical innovations have occurred throughout history, continually advancing our ability to treat, prevent and manage complex situations. For example, the first vaccine for smallpox in the 18th century, the measures implemented by Florence Nightingale in the Crimean War at the end of the 19th century to prevent infection and dramatically reduce deaths, the development of antibiotics in the 1920s and the world's first organ transplant three decades later. However, the 21st century has brought even more progress, with technological advances redefining the healthcare sector. At AWS we are committed to providing technology that empowers healthcare organizations to deliver high quality, equitable care. Some of the biggest opportunities are around embracing the understanding that technology enables providers and healthcare teams to make health and care better. While this may seem obvious, it is still not broadly accepted. Showing the results of the impact of healthcare transformation though data driven approaches is critical to fill this awareness gap. The biggest opportunity I see is to build trust in the healthcare sector. For example, it is impossible these days to talk about innovation in healthcare without talking about generative AI. If we look at a clinician trust in generative AI and the extent to which they perceive it to be a helpful decision-making assistant, this will depend on multiple factors such as socio-ethical considerations, technical and design features, user characteristics, and expertise. These are considerations that need to be made whenever approaching a new innovation. AWS has long believed in and shared our customers' excitement about the power of artificial intelligence (AI) and machine learning (ML) to transform patient outcomes – from predicting bioactivity in drug discovery to automating complex medical image interpretation. At AWS, we have played a key role in democratizing ML and making it accessible to anyone. As a result, more than 100,000 customers rely on AWS ML services to transform their organizations. Now we're seeing the vast promise of generative AI in healthcare and life sciences, with the potential to accelerate innovations and increase efficiencies across the care continuum. For example, with generative AI on AWS, customers can predict protein properties, create customized patient engagements, drive unprecedented levels of scientist and clinician productivity, and streamline manual clinical processes to reduce burden. At AWS we are taking the same approach to generative AI as we have done with ML: delivering new innovations to make it easy, cost effective, and practical for healthcare and life sciences organizations to leverage technology in their organizations. As a clinician, I am a firm believer that technology can be an enabler for good in health and care. In your opinion, what is the single most important change that will better enable digital transformation in health systems? The most important change is going to be driven by the consumer of health and care and the need to deliver a personalized experience. In developed regions, we are in the midst of generational change from those who learned to use a mobile phone in their adulthood, to kids who can't imagine a time without a high-powered computer in their pocket. Digital should never be the goal, but the means instead. Otherwise, we will continue to face a digital gap for our aging population and a "not being enough" digital for our younger ones. We need to understand the specific characteristics of the person to be able to deliver the best health and care possible. We are moving towards a journey of personalized health which is an emerging approach to healthcare that tailor's medical treatment and prevention strategies to an individual's unique characteristics, including their genetic makeup, lifestyle, and environmental factors. The goal of personalized health is to accompany a person in their life journey and provide more effective and targeted therapies, including prevention actions while minimizing adverse reactions and healthcare costs. The person will drive that change because it will become evident that healthcare cannot continue to be left behind. We are starting to see a shift in the way transformation strategies are approached and this is key to deliver outcomes. What do you know now that you wish you had known when you were starting out as an innovator? I wish some had explained to me from the beginning that the most important thing in anything you want to achieve at work is that you must understand people to understand business. Many of the problems we face today are so large and widespread, no organization can solve them alone. In organizations, innovation involves the collaboration of people and teams with different knowledge, experience and expertise. For example, at AWS, we have played a key role in democratizing ML and making it accessible to anyone who wants to use it, including more than 100,000 customers of all sizes and industries. Traditionally, digital transformation projects have been merely IT projects, but when we want to truly transform an organization these projects need to become strategic, multidisciplinary and IT-enabled. This is the first step to see tangible outcomes. The second step would be the understanding that these are truly not "projects" that do not connect, even if they happen in different departments, but a journey instead. The word project has the connotation of "start" and "stop" and innovation should never stop, it should iterate. Lastly, we need to clearly articulate the problem we are aiming to solve, how we are going to measure success, and make sure, as hard as it might be, that measurement occurs. Agreeing on outcomes and making them a north star is a key component to facilitating change. Without understanding the culture and managing the change, improvement will not be seen. Where do you see digital health moving in the next ten years? While we generally do not make predictions like this, I'm seeing a lot of promising work happening today that will surely shape the future of healthcare. The transformative influence of technology is pervasive, touching every aspect of our lives and altering the way we live, work, and interact. Revolutionizing work and learning: the way we work is undergoing a seismic shift. In the healthcare industry this is no different. Technology is and will continue to be immersed in everything we do. The key is to build the journey in a manner that delivers tangible outcomes, helping to build trust such as ensuring responsible AI. At AWS we build foundation models with responsible AI in mind at each stage of its comprehensive development process. Throughout design, development, deployment, and operations we consider a range of factors including accuracy, fairness, intellectual property and copyright considerations, appropriate usage, toxicity, and privacy. We build solutions to address these issues into our processes for acquiring training data, into the FMs (Foundation Models) themselves, and into the technology that we use to pre-process user prompts and post-process outputs. For all our FMs, we invest actively to improve our features, and to learn from customers as they experiment with new use cases. At AWS, we know that generative AI technology and how it is used will continue to evolve, posing new challenges that will require additional attention and mitigation. Together with academic, industry and government partners, we are committed to the continued development of generative AI in a responsible way. With the advancements on AI or generative AI there are lot of discussions on the impact on human and what will it mean to us, specifically on healthcare. Emotional intelligence provides human insights and empathy, but AI brings efficiency and analytical capabilities. That is why, in addition to career competencies, those that develop emotional intelligence skills with the learning and competencies of generative AI will be the leaders of the future. In your academic or work career, were there any mentors who have helped you grow along the way? What's the best piece of advice you have ever received? I have been very fortunate to work with amazing leaders across my career. I have also encountered leaders that have shown me what not to do and I am thankful for both. Challenge is good, it helps you grow, learn and get out of your comfort zone. Great challenges open great opportunities. You need embrace challenge, learn to surround yourself with talent and passion, and invest time with your team and stakeholders, this would be one of the best lessons I learned. Change is hard and influencing a culture of innovation requires investment of the leader's time. You don't need to have a team to be a leader, you don´t need to have a reporting structure to influence the teams around you. The combination of understanding the motivation of the people you are working with, investing time in getting to know them, be stubborn in the vision but flexible in the details, support them as people and not only as peers or reports and above all building a safe environment where members trust each other, are critical steps towards building high performing teams. In this last part I always try to "lead by example" and challenge my teams, peers and leaders to do the same. What are your passions outside of work? I have and incredible spouse and two amazing daughters which are my number one passion. Spend time with them, enjoying time and sharing their joys, working together through life and pursuing their dreams is where I love to spend my time. I am also very lucky to have amazing parents that have created a very high bar for me around human values such as integrity, kindness, humility, passion and decidedness'. Spend some time exercising and listening to music or enjoy time with my extended family and close friends and have fun in "aperitivos", which is a Spanish tradition of having a small "tapa" before lunch or extending it before night during the weekends are some of my other passions. I really enjoy travel as well, I do that for work and I love doing it for fun, getting immersed and learning from different cultures helps you incredibly grow as a person and implicitly as a leader. You have been a recipient of prestigious awards and recognitions over the years, the recent being named as one of the Most Admired Women in Digital Health to follow in 2024. Our readers would love to know the secret mantra behind your success. Embrace your dreams and find your sense of purpose. If you do not know where you are going, it will be difficult for you to get there. Why are you doing what you are doing? You need to find your passion. Without passion you will be unlikely to succeed. Once you find your passion is easier to ensure dedication and commitment and put in the hard work necessary to excel. I've always approached my endeavors with a strong work ethic, a willingness to go the extra mile, and a determination to see tasks through to completion. Once you find your "why" be ready to do the following every day, it is what I call my day-to-day equation: start by reflecting, set up some time at the start of your day to think first, then prepare yourself and combine it with discipline and flexibility and then do it again, and again. Be aware you will never be successful alone. Success comes from teamwork and is important to invest time in it. Also, need to embrace that success is rarely a linear path; it often involves overcoming obstacles, bouncing back from setbacks, and persevering through challenges. My mantra emphasizes resilience, the ability to remain focused, stay positive, and quickly pivot when faced with adversity. This mindset has helped me navigate through difficult situations, learn from failures, and ultimately emerge stronger and more experienced. Success is the combination of preparation, you have to study, every day, be curious and learn, be disciplined, it is ok to fail, stand up and try again and be flexible, sometimes to get to a certain place you might need to change directions. Opportunities will come, be ready to adjust. Where do you see yourself in the next 5 years? In the next five years, I see myself continuing to play a pivotal role in driving digital transformation initiatives within the healthcare industry. I look to continue to grow and develop my skills and expertise in responsible healthcare digital transformation. Continue to learn from my colleagues and help others to learn. I will continue to look for opportunities where I can leverage my experience and knowledge to mentor and guide others, fostering a collaborative and supportive work environment that nurtures talent and breeds excellence. Ultimately, my goal is to contribute to the development of a connected, intelligent, and human-centric healthcare ecosystem. By fostering partnerships with technology companies, research institutions, and healthcare organizations, I aspire to drive innovation that can positively impact lives and shape the future of healthcare delivery. I'm driven by the desire to make healthcare better today so it can be sustainable for the future. What is the one piece of advice that you can share with other professionals in your industry? We are all patients or going to be patients some day in our lives. Making healthcare better is a right and a responsibility of all of us. If you work in healthcare and aim to improve it make sure you are obsessed with making it better, with showing impact on healthcare outcomes and to do that you need to be customer obsessed. In Amazon we aim to be earth's most customer-centric company and our commitment is to make our customers' lives easier. We are customer obsessed and this is not just one of our leadership principles, it is true in the way we live our day to day. This was one of the main drivers that had me join Amazon Web Services. This statement is critical to drive growth, instead of "pushing" things to the market start by understanding what the client needs instead and work backwards from there. This needs to be accompanied by a long term thinking, which is another of our leadership principles, because it might mean that you might "lose a sale" in the short term because maybe at that point what you can offer if that is not what the customer needs, and you need to be ok with that, help recognize it and be transparent because in the long term, to earn the trust of the customer will make you become a key element in their overall journey and opportunities will naturally come. - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367114/ - https://healthtechmagazine.net/article/2022/12/ai-healthcare-2023-ml-nlp-more-perfcon - https://www.hipaajournal.com/healthcare-sees-60-yoy-increase-cyberattacks/
As we get caught up developing our careers and bringing up our families, we often think ahead of the time when we will have more time for ourselves. Those golden years of retirement – those years of leisure… and pleasure! If our expectations are too high as we head into those years, then there is a danger that we could be in for an unpleasant awakening. If we sit around expecting to be happy simply because we don't have to go to work every day, then we are likely to be disappointed. We need to recognise that happiness is a skill, and we develop that skill by understanding how our brains work. Our brains were simply not wired for happiness – they were wired for survival and to seek out threats. Think back to our ancestors who lived in caves – the focus was on survival. They likely didn't waste time wondering if they were happy – they were too busy hunting down animals for food and finding a way to make fire. They were driven by purpose, and when they were hunting, they were flooded with dopamine as they looked forward to that delicious meal they were going to eat. Everyone seems to be chasing happiness, believing that joy is the norm and we are entitled to be happy. We might even feel that everyone else is happy and there is something wrong with us if we are not! In turn, that can lead to a belief that bad feelings are a disease and that we need to seek out medication so that we also will be happy all the time. The demand for fast and easy spurts of happy chemicals results in 25% of American women over 60 being on anti-depressants. Rather than relying on the medical profession to "fix us," we should focus on understanding how our brains work. We are better off simply accepting our unhappy biology. It's uncomfortable to think that we're wired simply to survive and that our young brain developed according to our childhood experiences, but it helps to realise that we're all in the same boat because every person's brain is wired in their youth. Let's be thankful for our beautiful, complex brain! Humans have a very long childhood compared to other species because we learn continuously and thus wire our brain from lived experience. Lizards leave home at birth and if they don't run fast enough, a parent eats them. A mouse's childhood is two months long. A gazelle must run with the herd when it's a day old. Human childhood is extremely long by comparison and that lengthy period has its purpose. It evolved to build the neural network that guides us for life. No one has happy chemicals all the time and no one completely escapes negative feelings. It would be nice if you could get your brain fixed the way your car is fixed. It would be great if "society" could spark your happy chemicals for you. But it's better to know the biological facts and put the work in to change our own neural pathways. We can build new and healthy habits which will create new neural pathways. We can journal to process our emotions, and we can develop a meditation practice to reduce our stress levels. We can learn more about neuroscience so we can take charge of our brain. The neuroscience of happiness suggests that a balanced life is not merely about accumulating pleasures but about weaving these pleasures into a meaningful life. This could be the key to unlocking sustained wellbeing. The brain's reward system activates not only when we receive but also when we give. In other words, we are wired to derive joy from helping others, and that's why volunteering can be so life-affirming when we no longer work full time and have time to spare. Every life will be touched by setbacks and loss, and the ability to recover will affect our future happiness. Rapid recovery from adversity and the ability to sustain positive emotions contribute significantly to our overall happiness. The resilience of the human spirit can be traced back to neural mechanisms and has been well documented in literature such as Victor Frankl's Man's Search for Meaning. Frankl wrote, "Life is not primarily a quest for pleasure, as Freud believed, or a quest for power as Adler taught, but a quest for meaning. The greatest task for any person is to find meaning in their life." Recognising the fact that we are not here simply to "be happy" and that we need to find more purpose and meaning in our life is important. We need to accept the fact that no one is effortlessly happy because those happy brain chemicals evolved to reward steps taken toward meeting our needs. Everyone is unhappy sometimes because unhappy chemicals evolved to alert us to obstacles to meeting our needs. These chemicals are controlled by pathways built from past experience. Fortunately, we have billions of extra neurons ready to build new pathways. We can learn to redirect our electricity from potential threats to potential rewards, and thus shift ourselves from threat chemicals to happy chemicals. The neuroscience of happiness offers insights into how our brains process the experiences that make life worth living. It's not just about finding joy but it's about how we integrate this joy into a meaningful existence. We can find happiness in our lives by finding meaning and purpose and accepting life and all of its parts – both the good and the bad. By finding meaning in life, we can create our own happiness. I had relied on wine to make me feel happy for many years. As I reached 63 years, my health problems were accumulating. I felt exhausted and permanently worried that my breast cancer would return. I decided to quit drinking, and sure enough, my first few months of sobriety were tough, very tough. The benefits of quitting alcohol started to appear as promised. I lost weight, slept better, my skin looked great, eyes were clearer. I saved money – and yes, I even learned to love mornings. Yet in spite of all that good stuff, life felt rather flat. I seemed to have a lot of time on my hands. Time I wasn't quite sure what to do with. There were no despair-fests at 3 am but there were no highs either. I felt like I was facing a void. I decided I was suffering from anhedonia which is the inability to enjoy everyday pleasures. Sunsets, walking on the beach, meeting up with friends just didn't hit the happy spot. I worried that this dull and miserable place was "sobriety" and was on the verge of giving up many times. If this was sobriety, I wasn't sure it was for me. I decided to hang in there for a few months in the hope that the low would pass. I also felt just a bit "trapped." Everybody was so "proud of me" and my sober buddies urged me to stay strong and keep going. So I did, I just kept going, day after day, but the low mood continued for at least three months. I tried to smile and use the "fake it till I make it" strategy. I agreed with my sober buddies that yes, sobriety was awesome, whilst thinking – really? I had a light bulb moment. I decided I would design and facilitate a workshop for people who wanted to quit drinking. After all, I had 25 years of corporate experience in training and development. That was the day that tribesober.com was born… That's when the magic happened. Creating a website, designing the workshop, setting up a membership, starting a podcast, and connecting with other people on this journey kept me busy – and happy. Most importantly of all, it gave me a purpose and for the first time in years I felt that my life had meaning. Helping people to quit drinking and rediscover their health and happiness felt pretty good. Eight years later growing Tribe Sober still keeps me happy! Hindsight is a wonderful thing and at nearly nine years sober I can look back and analyse just what happened and hopefully this article will help others to understand and avoid that early low that can hit and often derail us in early sobriety. Thanks to a podcast interview I did with Dr. Loretta Breuning I now have a much better understanding of just why I felt so low a few months into sobriety. At the time, my impression was that my low mood had passed of its own accord but in reality that was not quite true. My low mood had passed because I had set a new goal (to start Tribe Sober) and was working in stages to achieve that goal. Working towards and achieving another step every day was keeping those happy brain chemicals flowing. Loretta explained to me that my upbeat mood (aka pink cloud) during those first few months was triggered by the fact that I'd set myself a goal to get sober and was making daily progress towards that goal. A few months into sobriety, my brain had ticked off this goal as "achieved," and now I was in limbo as there was no longer anything to aim for. Thanks to Loretta, I now understand that our "happy chemicals" don't just start working on their own – we have to do something to stimulate them. Rather than anhedonia being an unpleasant but essential stage on the journey to sobriety, we can avoid it completely. How cool is that ;-) So, I no longer advise people to brace themselves for a bout of depression in early sobriety. I advise them to find a project. If you're looking for a project, then why not consider improving your mental and physical health by creating an alcohol-free lifestyle? Many people in our community treated sobriety as a research project. They read books, they listened to podcasts they watched videos. They learned a great deal and within a few months they were loving their alcohol-free lives. If you'd like to get started on this lifechanging journey we can help you to kickstart your sobriety project with our free one-week Bootcamp which takes place on a Facebook group from 20th – 24th May. At Tribe Sober we help people to change their relationship with alcohol. How many years have you been drinking? Do you drink consistently – a glass or two of wine most evenings? Have you ever tried to take a break to test your dependence? Have you noticed an impact on your looks after a taking a break? Did you lose weight? Do you ever worry about your drinking? Do you feel happy in your retirement? This article is beautifully written. Thank you for sharing your personal journey. At 84 years old I still consider myself in recovery as an adult child of alcoholic parents. thank you so much for your kind words Norma xx Hats off to author Janet for not only beating alcoholism personally but for organizing a community to help others. Alcoholism ruined my life! Not because I drank, but because my father did. Every day was drama and some crisis in our household. In a way, my father's drinking was a blessing to me because I never touched the stuff, and never will. Drinkers don't realize the negative impact their behavior has on others around them. Please, if you don't drink now, don't start. And if you do, follow Janet's program. Amen. thank you so much Joyce – I'm sorry to hear that your childhood was impacted by your father's drinking but very happy that you've managed to avoid it yourself. As you know many children of alcoholics think it's their destiny to go the same way. I always say that genetics is the gun but lifestyle is the trigger. xx Very inspiring and informative. Thank you so much thank you JLS – discovering that our brains are wired to seek out threats rather than make us happy was a revelation to me – I found it very empowering to realise that happiness is a skill! I have been retired 12 years. Isolation due to the pandemic.has .taken a toll. I have been through breast cancer and treatment and have stopped drinking but have substituted chocolate. I have gained weight and feel depressed Hi Pat I also had breast cancer and the evidence is clear that there is a link between alcohol and breast cancer – so well done for ditching the booze! I'm sorry to hear that you are feeling depressed due to weight gain – we often turn to sweet things when we quit drinking as we miss the sugar in alcohol. In June 2023 I did a podcast interview with Dr Vera Tarman who is an expert in the weight loss field and has a free Facebook Group – my podcast is called Tribe Sober – available on Apple & Spotify so scroll through the episodes and you will find it! Before I place a comment on the article, which was well presented, I would like to ask for less, much fewer advertisements. It is so distracting to not go a paragraph without being assaulted by a video or ad. It takes away from the power of the article and is disrespectful to the author. I counted 13 ad popups in this one blog post. Crazy. I've learned to breeze by them, but it is so distracting I agree. That is so odd! I see no advertisements, commercials, or pop-ups on this site. I count 14 just in the article alone. Many others on the right side panel and the annoying one on the bottom. It's just how it works and how people make money, or a "subscription" of $$ per month to skip ads. Everyone wondered how people would make money on the internet in 1993…..now we know :) I look forward to seeing your comments on the article and I'm glad you feel it was well presented
I believe everyone deserves a safe and supportive environment, where they can process life experiences without feeling ashamed or judged. During my undergraduate studies, I discovered that my level of patience and creativity helped young learners to problem solve and process information at their own level. This was something that I wish I had experienced more during my own childhood. Growing up in a multigenerational African American household I heard a lot about familial and societal issues that I did not present and overheard them. Children are often described as silent witnesses. Life happens around them with very little explanation. Sometimes no explanation is needed, but what about those moments when it is? When provided with a developmentally appropriate explanation, safe space, and support to process the situation, most get through it just fine. However, when faced with experiences much bigger than they can comprehend and receiving little to no explanation and support to process, children's minds and bodies hold on to those experiences. - Listing categories Premium
SEA.AI Brain: How to Enhance Maritime Safety with Advanced Machine Vision SEA.AI has announced the release of 'Brain', a new tool designed to improve the capabilities of third-party thermal cameras. This system works alongside existing RADAR, AIS, and Telemetrics systems to provide a more comprehensive view of the sea's surface, which is vital for spotting potential dangers under various conditions. "All sailors take comfort and pride in comprehensive information delivered at the right time. No detail is too small if it ensures the safety of the crew, the vessel and the cargo," stated Marcus Warrelmann, CEO of SEA.AI, underscoring the value of precise and timely information for ensuring maritime safety. The Brain is engineered to address gaps in existing maritime vision systems, utilizing six years of accumulated maritime surface data from both online and offline sources. It continuously monitors the horizon and alerts the crew to any surface anomalies detected, enhancing the safety and effectiveness of maritime operations. The system builds upon existing over-and-under water detection technologies, proving useful even in difficult conditions such as large swells or nighttime. It can identify a variety of objects, including small boats, debris, lost cargo, or individuals in distress. Solenn Gouerou, Head of Marketing at SEA.AI, discussed the increasing complexity of maritime navigation. "Shipping lanes are more crowded, and there is simply more junk floating on our waters. Our goal was to develop a technology that complements existing third-party thermal cameras with AI and advanced optics to provide better visibility." The SEA.AI Brain is proactive, directing the crew's attention to potential hazards before they pose a significant threat. This feature allows the crew to manage other essential duties more efficiently while maintaining safety. Supported by extensive data contributions from the global maritime community, the Brain aims to enhance safety and security at sea. This system is compatible with current navigational and monitoring systems and operates continuously, learning and adapting to new conditions. Scheduled to be available for third-party IP cameras that support ONVIF S standards by Summer 2024, SEA.AI's Brain offers a valuable addition to maritime safety tools, enhancing surveillance and response capabilities.
Birth to 15 Months Hepatitis B (HepB): Administered in three doses. The first dose is given at birth, the second dose at 1-2 months, and the third dose at 6-18 months. Rotavirus (RV): Given in two or three doses, depending on the vaccine type. The first dose is administered at 2 months, with subsequent doses at 4 months and (for some vaccines) 6 months. Diphtheria, Tetanus, and Pertussis (DTaP): This vaccine is given in five doses. The first three doses are given at 2, 4, and 6 months, the fourth dose between 15-18 months, and the fifth dose at 4-6 years. Haemophilus influenzae type b (Hib): Administered in three or four doses, depending on the vaccine. The first dose is at 2 months, with subsequent doses at 4 months, 6 months (if needed), and a booster between 12-15 months. Pneumococcal conjugate vaccine (PCV13): Given in four doses at 2, 4, 6 months, and a booster at 12-15 months. Inactivated Poliovirus Vaccine (IPV): Administered in four doses at 2, 4 months, 6-18 months, and a booster at 4-6 years. Influenza (Flu): Annual vaccination starting at 6 months of age, with two doses given at least four weeks apart during the child's first flu season. 12 Months to 18 Years Measles, Mumps, and Rubella (MMR): Two doses are recommended. The first dose at 12-15 months and the second dose at 4-6 years. Varicella (Chickenpox): Two doses are recommended. The first dose at 12-15 months and the second dose at 4-6 years. Hepatitis A (HepA): Two doses are given, the first at 12-23 months and the second 6 months following the first dose. Meningococcal conjugate vaccine (MenACWY): First dose at 11-12 years with a booster at 16 years. Human Papillomavirus (HPV): The vaccination series can start at 9 years, with two doses administered at least six months apart for those starting the series before their 15th birthday. Those starting the series later receive three doses. Tetanus, Diphtheria, and Pertussis (Tdap): A single dose is recommended at 11-12 years, with Td or Tdap booster every 10 years thereafter. Meningococcal B vaccine (MenB): This vaccine is recommended at 16-18 years, with the schedule depending on the vaccine brand. Special Considerations and Catch-Up Vaccinations Some children may require catch-up vaccinations if they missed or delayed certain vaccines. Additionally, children with specific health conditions or those traveling internationally may need additional vaccines or to follow an altered schedule. Vaccinations are a critical part of pediatric healthcare, offering protection against various infectious diseases. Following the recommended vaccination schedule is key to ensuring your child's health and well-being. This schedule provides a foundation, but always consult with a healthcare provider to address any specific needs or concerns for your child. Remember, vaccination schedules can change, and staying informed through reliable sources like the CDC or your local health department is important.

Subsets and Splits

No community queries yet

The top public SQL queries from the community will appear here once available.