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36,800,593 | Clinical and biological significance of RNA N6-methyladenosine regulators in Alzheimer disease. | RNA N6-methyladenosine (m6A) regulators are essential for a variety of biological functions, such as early development, viral infections, and cancer. However, their roles in Alzheimer disease (AD) are still not very clear. Here, 16 significant m6A regulators were identified using difference analysis between AD patients... |
36,800,393 | Computer assisted diagnosis of Alzheimers disease using statistical likelihood-ratio test. | The purpose of this work is to present a computer assisted diagnostic tool for radiologists in their diagnosis of Alzheimers disease. A statistical likelihood-ratio procedure from signal detection theory was implemented in the detection of Alzheimers disease. The probability density functions of the likelihood ratio we... |
36,800,287 | The impact of attending historically Black colleges and universities on cognitive decline in Black adults A longitudinal analysis in the KHANDLE and STAR cohorts. | Black students attending predominantly White institutions (PWIs) versus historically Black colleges and universities (HBCUs) report more harmful discrimination and develop worse mental health outcomes, potentially offsetting the established benefits of college for lowering dementia incidence. Black participants in two ... |
36,800,228 | Caprylic acid attenuates amyloid-β proteotoxicity by supplying energy via β-oxidation in an Alzheimers disease model of the nematode | Computer-based analysis of motility was used as a measure of amyloid-β (Aβ) proteotoxicity in the transgenic strain GMC101, expressing human Aβ |
36,799,733 | What happens when people develop dementia whilst working An exploratory multiple case study. | This study is an in-depth exploration of the unfolding experiences of five persons who developed dementia while still in paid workemployment, and of their significant others. Namely, we explore how they experienced the actions and decisions taken with respect to work, and what the consequences meant to them. A qualitat... |
36,799,660 | Using Explainable Artificial Intelligence in the Clock Drawing Test to Reveal the Cognitive Impairment Pattern. | The prevalence of dementia is currently increasing worldwide. This syndrome produces a deterioration in cognitive function that cannot be reverted. However, an early diagnosis can be crucial for slowing its progress. The Clock Drawing Test (CDT) is a widely used paper-and-pencil test for cognitive assessment in which a... |
36,799,565 | Brain deficit patterns of metabolic illnesses overlap with those for major depressive disorder A new metric of brain metabolic disease. | Metabolic illnesses (MET) are detrimental to brain integrity and are common comorbidities in patients with mental illnesses, including major depressive disorder (MDD). We quantified effects of MET on standard regional brain morphometric measures from 3D brain MRI as well as diffusion MRI in a large sample of UK BioBank... |
36,799,538 | Biomimetic Remodeling of Microglial Riboflavin Metabolism Ameliorates Cognitive Impairment by Modulating Neuroinflammation. | Neuroinflammation, for which microglia are the predominant contributors, is a significant risk factor for cognitive dysfunction. Riboflavin (also known as vitamin B2) ameliorates cognitive impairment via anti-oxidative stress and anti-inflammation properties however, the underlying mechanisms linking riboflavin metabol... |
36,799,441 | The β-adrenergic hypothesis of synaptic and microglial impairment in Alzheimers disease. | Alzheimers disease (AD) is a progressive neurodegenerative disease originating partly from amyloid β protein-induced synaptic failure. As damaging of noradrenergic neurons in the locus coeruleus (LC) occurs at the prodromal stage of AD, activation of adrenergic receptors could serve as the first line of defense against... |
36,799,439 | NLRP3-directed antisense oligonucleotides reduce microglial immunoactivities in vitro. | Alzheimers disease (AD) is associated with the cerebral deposition of Amyloid-β (Aβ) peptide, which leads to NLRP3 inflammasome activation and subsequent release of interleukin-1β (IL-1β) and interleukin-18 (IL-18). NLRP3 reduction has been found to increase microglial clearance, protect from synapse loss, and suppress... |
36,799,408 | Preclinical and translational models for delirium Recommendations for future research from the NIDUS delirium network. | Delirium is a common, morbid, and costly syndrome that is closely linked to Alzheimers disease (AD) and AD-related dementias (ADRD) as a risk factor and outcome. Human studies of delirium have advanced our knowledge of delirium incidence and prevalence, risk factors, biomarkers, outcomes, prevention, and management. Ho... |
36,799,336 | Discovery of reversible selective monoamine oxidase B inhibitors with anti-acetylcholinesterase activity derived from 4-oxo-N-4-diphenyl butanamides. | null |
36,799,220 | The ScreeLing Detecting Semantic, Phonological, and Syntactic Deficits in the Clinical Subtypes of Frontotemporal and Alzheimers Dementia. | The ScreeLing is a screening instrument developed to assess post-stroke aphasia, via the linguistic levels Syntax, Phonology, and Semantics. It could also be a useful test for the clinical subtypes of frontotemporal dementia (FTD) and Alzheimers dementia (AD), as specific and often selective disorders are expected. Its... |
36,798,942 | Autonomic nervous system and cardiac neuro-signaling pathway modulation in cardiovascular disorders and Alzheimers disease. | The heart is a functional syncytium controlled by a delicate and sophisticated balance ensured by the tight coordination of its several cell subpopulations. Accordingly, cardiomyocytes together with the surrounding microenvironment participate in the heart tissue homeostasis. In the right atrium, the sinoatrial nodal c... |
36,798,617 | pKr-2 induces neurodegeneration | We recently demonstrated that prothrombin kringle-2 (pKr-2) derived from blood-brain barrier (BBB) disruption could induce hippocampal neurodegeneration and object recognition impairment through neurotoxic inflammatory responses in the five familial Alzheimers disease mutation (5XFAD) mice. In the present study, we aim... |
36,798,352 | Resting-State Functional Connectivity Changes in Older Adults with Sleep Disturbance and the Role of Amyloid Burden. | Sleep and related disorders could lead to changes in various brain networks, but little is known about the role of amyloid β (Aβ) burden-a key Alzheimers disease (AD) biomarker-in the relationship between sleep disturbance and altered resting state functional connectivity (rsFC) in older adults. This cross-sectional st... |
36,798,327 | ApoE Alzheimers Disease Aβ-amyloid plaque morphology varies according to APOE isotype. | null |
36,798,314 | Heterogeneity in Preclinical Alzheimers Disease Trial Cohort Identified by Image-based Data-Driven Disease Progression Modelling. | Undetected biological heterogeneity adversely impacts trials in Alzheimers disease because rate of cognitive decline - and perhaps response to treatment - differs in subgroups. Recent results show that data-driven approaches can unravel the heterogeneity of Alzheimers disease progression. The resulting stratification i... |
36,798,311 | Sex-specific declines in cholinergic-targeting tRNA fragments in the nucleus accumbens in Alzheimers disease. | Females with Alzheimers disease (AD) present accelerated damage to cholinergic neurons and undergo accelerated cognitive decline compared to males, but the underlying mechanisms are incompletely understood. Here, we report that tRNA fragments (tRFs) carrying complementary sequences to cholinergic transcripts (CholinotR... |
36,798,301 | Contributions of rare and common variation to early-onset and atypical dementia risk. | We collected and analyzed genomic sequencing data from individuals with clinician- diagnosed early-onset or atypical dementia. Thirty-two patients were previously described, with sixty-eight newly described in this report. Of those sixty-eight, sixty-two patients reported Caucasian, non-Hispanic ethnicity and six repor... |
36,798,226 | MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state. | Genome-wide association studies (GWAS) have identified many modifiers of Alzheimer disease (AD) risk enriched in microglia. Two of these modifiers are common variants in the |
36,798,198 | Epistatic Features and Machine Learning Improve Alzheimers Risk Prediction Over Polygenic Risk Scores. | Polygenic risk scores (PRS) are linear combinations of genetic markers weighted by effect size that are commonly used to predict disease risk. For complex heritable diseases such as late onset Alzheimers disease (LOAD), PRS models fail to capture much of the heritability. Additionally, PRS models are highly dependent o... |
36,798,012 | Safety, tolerability, and pharmacokinetics of fluoropezil (DC20), a novel AChE inhibitor A phase I study in healthy young and elderly Chinese subjects. | The present study evaluated the safety, tolerability, and pharmacokinetics of fluoropezil (DC20), a novel AChE inhibitor under development for the treatment of Alzheimers disease (AD) in otherwise healthy young and elderly Chinese subjects. The study of young subjects included the multiple ascending-dose (MAD) arm (2 a... |
36,797,783 | Early activation of Toll-like receptor-3 reduces the pathological progression of Alzheimers disease in APPPS1 mouse. | Toll-like receptor 3 (TLR3) plays an important role in the immuneinflammatory response in the nervous system and is a main pathological feature of Alzheimers disease (AD). This study investigates the role of early activation of TLR3 in the pathophysiological process of AD. In the experiment, the agonist of TLR3, Poly(I... |
36,797,613 | Herbal Therapeutics for Alzheimers Disease Ancient Indian Medicine System from the Modern Viewpoint. | Alzheimers is a chronic neurodegenerative disease where amyloid-beta (Aβ) plaques and neurofibrillary tangles are formed inside the brain. It is also characterized by progressive memory loss, depression, neuroinflammation, and derangement of other neurotransmitters. Due to its complex etiopathology, current drugs have ... |
36,797,545 | Cancer and Alzheimers Inverse Correlation an Immunogenetic Analysis. | Numerous studies have demonstrated an inverse link between cancer and Alzheimers disease (AD), with data suggesting that people with Alzheimers have a decreased risk of cancer and vice versa. Although other studies have investigated mechanisms to explain this relationship, the connection between these two diseases rema... |
36,797,031 | Validity Assessment of an Automated Brain Morphometry Tool for Patients with De Novo Memory Symptoms. | Automated volumetric analysis of structural MR imaging allows quantitative assessment of brain atrophy in neurodegenerative disorders. We compared the brain segmentation performance of the AI-Rad Companion brain MR imaging software against an in-house FreeSurfer 7.1.1Individual Longitudinal Participant pipeline. T1-wei... |
36,796,949 | Neurodegenerative disorders From clinicopathology convergence to systems biology divergence. | Neurodegenerative diseases are multifactorial. This means that several genetic, epigenetic, and environmental factors contribute to their emergence. Therefore, for the future management of these highly prevalent diseases, it is necessary to change perspective. If a holistic viewpoint is assumed, the phenotype (the clin... |
36,796,943 | Models of precision medicine for neurodegeneration. | The clinicopathologic model that defines neurodegenerative disorders has remained unchanged for over a century. According to it, clinical manifestations are defined and explained by a given pathology, that is, by the burden and distribution of selected proteins aggregated into insoluble amyloids. There are two logical ... |
36,796,942 | Biomarkers of diagnosis, prognosis, pathogenesis, response to therapy Convergence or divergence Lessons from Alzheimers disease and synucleinopathies. | Alzheimers disease (AD) is the most common disorder associated with cognitive impairment. Recent observations emphasize the pathogenic role of multiple factors inside and outside the central nervous system, supporting the notion that AD is a syndrome of many etiologies rather than a heterogeneous but ultimately unifyin... |
36,796,940 | The theoretical problems of prodrome and phenoconversion in neurodegeneration. | The recognition of and approach to prodromal symptoms, those which manifest before a diagnosis can be ascertained at the bedside, are of increasing interest in neurodegenerative research. A prodrome is conceived of as an early window into a disease, a critical time when putative disease-modifying interventions may be b... |
36,796,939 | Finding the falsification threshold of the toxic proteinopathy hypothesis in neurodegeneration. | A biomedical hypothesis is a theoretical assumption amenable to being tested in a randomized clinical trial. The main hypotheses in neurodegenerative disorders are based on the concept that proteins accumulate in an aggregated fashion and trigger toxicity. The toxic proteinopathy hypothesis posits that neurodegeneratio... |
36,796,753 | Deletion of Arrb2 down-regulates autophagy in the mouse hippocampus via Akt-mTOR pathway activation. | The cytoplasmic multifunctional adaptor protein β-arrestin 2 (Arrb2) is involved in the occurrence of various nervous system diseases, such as Alzheimers disease and Parkinsons disease. Previous laboratory studies have shown that the expression and function of the Arrb2 gene was increased in valproic acid-induced autis... |
36,796,730 | Understanding Alzheimers Disease in the Context of Aging Findings from Applications of Stochastic Process Models to the Health and Retirement Study. | There is growing literature on applications of biodemographic models, including stochastic process models (SPM), to studying regularities of age dynamics of biological variables in relation to aging and disease development. Alzheimers disease (AD) is especially good candidate for SPM applications because age is a major... |
36,796,705 | Lung function and risk of incident dementia a prospective cohort study of 431,834 individuals. | Whether lung function prospectively affects cognitive brain health independent of their overlapping factors remains largely unknown. This study aimed to investigate the longitudinal association between decreased lung function and cognitive brain health and to explore underlying biological and brain structural mechanism... |
36,796,651 | Multiple low-dose radiation-induced neuronal cysteine transporter expression and oxidative stress are rescued by N-acetylcysteine in neuronal SH-SY5Y cells. | Recently, several studies have demonstrated that low-dose radiation (LDR) therapy has positively impacts on the treatment of Alzheimers disease (AD). LDR suppresses the production of pro-neuroinflammation molecules and improves cognitive function in AD. However, it is unclear whether direct exposure to LDR causes benef... |
36,796,600 | NMDAR-Arc signaling is required for Memory Updating and is disrupted in Alzheimers Disease. | Memory deficits are central to many neuropsychiatric diseases. During acquisition of new information memories can become vulnerable to interference, yet mechanisms that underlie interference are unknown. We describe a novel transduction pathway that links NMDAR to AKT signaling via the IEG Arc, and evaluate its role in... |
36,796,590 | Aquaporin-4 in glymphatic system, and its implication for central nervous system disorders. | The clearance function is essential for maintaining brain tissue homeostasis, and the glymphatic system is the main pathway for removing brain interstitial solutes. Aquaporin-4 (AQP4) is the most abundantly expressed aquaporin in the central nervous system (CNS) and is an integral component of the glymphatic system. In... |
36,796,586 | Extracellular vesicles derived from Porphyromonas gingivalis induce vagus nerve-mediated cognitive impairment. | Porphyromonas gingivalis (PG)-infected periodontitis is in close connection with the development of Alzheimers disease (AD). PG-derived extracellular vesicles (pEVs) contain inflammation-inducing virulence factors, including gingipains (GPs) and lipopolysaccharide (LPS). To understand how PG could cause cognitive decli... |
36,796,566 | Osmolytes Wonder molecules to combat protein misfolding against stress conditions. | The proper functioning of any protein depends on its three dimensional conformation which is achieved by the accurate folding mechanism. Keeping away from the exposed stress conditions leads to cooperative unfolding and sometimes partial folding, forming the structures like protofibrils, fibrils, aggregates, oligomers,... |
36,795,955 | Study of neuropathological changes and dementia in 100 centenarians in The 90 Study. | The association between neuropathological changes and dementia among centenarians and nonagenarians remains unclear. We examined brain tissue from 100 centenarians and 297 nonagenarians from The 90 Study, a community-based longitudinal study of aging. We determined the prevalence of 10 neuropathological changes and com... |
36,795,937 | Identification of circRNAs linked to Alzheimers disease and related dementias. | Circular RNAs (circRNAs) exhibit selective expression in the brain and differential regulation in Alzheimers disease (AD). To explore the role of circRNAs in AD, we investigated how circRNA expression varies between brain regions and with AD-related stress in human neuronal precursor cells (NPCs). Ribosomal RNA-deplete... |
36,795,879 | Neuroimaging in Dementia. | Neurodegenerative diseases are significant health concerns with regard to morbidity and social and economic hardship around the world. This review describes the state of the field of neuroimaging measures as biomarkers for detection and diagnosis of both slowly progressing and rapidly progressing neurodegenerative dise... |
36,795,776 | Neuropathology-based APOE genetic risk score better quantifies Alzheimers risk. | Apolipoprotein E (APOE) ε4-carrier status or ε4 allele count are included in analyses to account for the APOE genetic effect on Alzheimers disease (AD) however, this does not account for protective effects of APOE ε2 or heterogeneous effect of ε2, ε3, and ε4 haplotypes. We leveraged results from an autopsy-confirmed AD... |
36,795,751 | null | Microglia play a critical role in the pathogenic process of neurodegenerative diseases, such as Parkinsons disease (PD) and Alzheimers disease (AD). Upon pathological stimulation, microglia are converted from a surveillant to an overactivated phenotype. However, the molecular characters of proliferating microglia and t... |
36,795,603 | CSF biomarker concordance with amyloid PET in Phase 3 studies of aducanumab. | We assessed the use of cerebrospinal fluid (CSF) biomarkers as an alternative to positron emission tomography (PET) for brain amyloid beta (Aβ) pathology confirmation in the EMERGE and ENGAGE clinical trials. EMERGE and ENGAGE were randomized, placebo-controlled, Phase 3 trials of aducanumab in participants with early ... |
36,795,539 | Synthesis and In Vitro and In Vivo Evaluation of | Accurate quantification of amyloid beta (Aβ) plaques is an important indicator for Alzheimers disease diagnosis and treatment. For this purpose, new highly sensitive Aβ tracers were designed by regulating the position and number of nitrogen atoms. A series of derivatives of florbetapir (AV45) containing different numbe... |
36,795,525 | Research on Diagnostic Markers for Post-Stroke Cognitive Impairment. | Post-stroke cognitive impairment (PSCI) is secondary to stroke, and is a significant burden for patients, their families and society as a whole. Our study aimed to investigate the predictive value of β-amyloid 42 (Aβ42) and hemoglobin (Hb) in the diagnosis of PSCI. 120 patients were selected and then assigned to either... |
36,795,184 | Biomarkers Role and Scope in Neurological Disorders. | Neurological disorders pose a great threat to social health and are a major cause for mortality and morbidity. Effective drug development complemented with the improved drug therapy has made considerable progress towards easing symptoms associated with neurological illnesses, yet poor diagnosis and imprecise understand... |
36,795,041 | Challenges and opportunities of diagnostic markers of Alzheimers disease based on structural magnetic resonance imaging. | This article aimed to carry out a narrative literature review of early diagnostic markers of Alzheimers disease (AD) based on both micro and macro levels of pathology, indicating the shortcomings of current biomarkers and proposing a novel biomarker of structural integrity that associates the hippocampus and adjacent v... |
36,794,757 | Simulating the multicausality of Alzheimers disease with system dynamics. | In Alzheimers disease (AD), cognitive decline is driven by various interlinking causal factors. Systems thinking could help elucidate this multicausality and identify opportune intervention targets. We developed a system dynamics model (SDM) of sporadic AD with 33 factors and 148 causal links calibrated with empirical ... |
36,794,714 | The impact of study factors in the association of periodontal disease and cognitive disorders systematic review and meta-analysis. | The aim was to assess study factors that impact the association of cognitive disorders in people with periodontal disease (PD). Medline, EMBASE and Cochrane databases were searched until February 2022 using keywords and MeSH (periodon OR tooth loss OR missing teeth) AND (dementia OR Alzheimers Disease OR cognitive). Ob... |
36,794,623 | Reverse electron transfer is activated during aging and contributes to aging and age-related disease. | Mechanisms underlying the depletion of NAD |
36,794,570 | Analysis of clinical characteristics of mirror and TV signs in Alzheimers disease and dementia with Lewy bodies. | This study explored the clinical features of dementia with Lewy bodies (DLB) and Alzheimers disease (AD) and analyzed the differences in neurologic syndromes, including mirror and TV signs, between different groups. Patients with AD and DLB (325 and 115, respectively) hospitalized in our institution were enrolled. We c... |
36,794,286 | Protective effect of saffron carotenoids against amyloid beta-induced neurotoxicity in differentiated PC12 cells via the unfolded protein response and autophagy. | The preventive effect of saffron against Alzheimers disease (AD) has been reported. Herein, we studied the effect of Cro and Crt, saffron carotenoids, on the cellular model of AD. The MTT assay, flow cytometry, and elevated p-JNK, p-Bcl-2, and c-PARP indicated the AβOs-induced apoptosis in differentiated PC12 cells. Th... |
36,794,021 | Current understanding of metal-dependent amyloid-β aggregation and toxicity. | The discovery of effective therapeutics targeting amyloid-β (Aβ) aggregates for Alzheimers disease (AD) has been very challenging, which suggests its complicated etiology associated with multiple pathogenic elements. In AD-affected brains, highly concentrated metals, such as copper and zinc, are found in senile plaques... |
36,793,992 | Reducing decoys focuses fighting microglia. | Genetic variation linked to lower levels of soluble ST2, a decoy cytokine receptor for IL-33, may protect against Alzheimers disease in female |
36,793,979 | Corrigendum to MUTYH Actively Contributes to Microglial Activation and Impaired Neurogenesis in the Pathogenesis of Alzheimers Disease. | This corrects the article DOI 10.115520218635088.. |
36,793,451 | CSF-Targeted Proteomics Indicate Amyloid-Beta Ratios in Patients with Alzheimers Dementia Spectrum. | According to recent studies, amyloid- A total of 719 participants were found eligible for inclusion. Patients were then categorized into cognitively normal (CN), mild cognitive impairment (MCI), and AD and underwent an assessment of A All investigated peptides corresponded significantly to A Our research suggests poten... |
36,793,447 | Digital phenotyping and the (data) shadow of Alzheimers disease. | In this paper, we examine the practice and promises of digital phenotyping. We build on work on the data self to focus on a medical domain in which the value and nature of knowledge and relations with data have been played out with particular persistence, that of Alzheimers disease research. Drawing on research with re... |
36,792,546 | Helicobacter pylori-derived outer membrane vesicles contribute to Alzheimers disease pathogenesis via C3-C3aR signalling. | The gut microbiota represents a diverse and dynamic population of microorganisms that can influence the health of the host. Increasing evidence supports the role of the gut microbiota as a key player in the pathogenesis of neurodegenerative diseases, including Alzheimers disease (AD). Unfortunately, the mechanisms behi... |
36,792,062 | Mitophagy A promising therapeutic target for neuroprotection during aging and age-related diseases. | Mitochondria and mitochondria-mediated signaling pathways are known to control synaptic signaling as well as long-lasting changes in neuronal structure and function. Mitochondrial impairment is linked to synaptic dysfunction in normal aging and age-associated neurodegenerative ailments including Parkinsons disease (PD)... |
36,791,792 | Guiding safer risperidone prescribing in Alzheimers disease with therapeutic drug monitoring. | Previous analysis of pharmacokinetic data on risperidone treated patients with dementia predicted that twenty percent had concentration-to-dose (CD) ratios of the active moiety (risperidone and 9-hydroxy (OH)-risperidone) above 14ngml per mgday, which were in turn associated with a greater risk of extrapyramidal side-e... |
36,791,255 | DementiaBank Theoretical Rationale, Protocol, and Illustrative Analyses. | Dementia from Alzheimers disease (AD) is characterized primarily by a significant decline in memory abilities however, language abilities are also commonly affected and may precede the decline of other cognitive abilities. To study the progression of language, there is a need for open-access databases that can be used ... |
36,790,720 | Evaluating the neuroprotective effect of Spirulina platensis-loaded niosomes against Alzheimers disease induced in rats. | Alzheimers disease (AD) is a progressive neurodegenerative disease that is characterized by memory loss, changes in behavior, and avoidance of social bonds. Aluminum is one of the main risk factors in the development of AD. Spirulina platensis (SP) is a microalga that improves motor and cognitive skills and prevents ce... |
36,790,717 | Elucidating the promising role of traditional Chinese medicine in neuroprotection against oxidative stress encompassing Alzheimers disease. | Medicinal plants are being used from time immemorial for their therapeutic benefits and have immense value in the therapy of neurodegenerative disorders. One of the most important neurological disorders is Alzheimers disease (AD) which is a major contributor to dementia and is accompanied by abundant oxidative stress i... |
36,790,638 | Technical Review of Clinical Outcomes Assessments Across the Continuum of Alzheimers Disease. | Insight into the relationship between concepts that matter to the people affected by Alzheimers disease (AD) and the clinical outcome assessments (COAs) commonly used in AD clinical studies is limited. Phases 1 and 2 of the What Matters Most (WMM) study series identified and quantitatively confirmed 42 treatment-relate... |
36,790,601 | Blood and cerebrospinal fluid biomarker changes in patients with HIV-associated neurocognitive impairment treated with lithium analysis from a randomised placebo-controlled trial. | HIV-associated neurocognitive disorders (HAND) persist in the era of antiretroviral therapy (ART). Thus, ART does not completely halt or reverse the pathological processes behind HAND. Adjuvant mitigating treatments are, therefore, prudent. Lithium treatment is known to promote neuronal brain-derived neurotrophic facto... |
36,790,294 | Gender of study partners and research participants associated with differences in study partner ratings of cognition and activity level. | Studies of Alzheimers disease (AD) typically include study partners (SPs) who report on participants cognition and function. Prior studies show SP reports differ depending on the relationship between the SP and participant, that is, spouse or adult child. Adult children SPs are typically female. Could differing reports... |
36,790,009 | Multiomics profiling of human plasma and cerebrospinal fluid reveals ATN-derived networks and highlights causal links in Alzheimers disease. | This study employed an integrative system and causal inference approach to explore molecular signatures in blood and CSF, the amyloidtauneurodegeneration AT(N) framework, mild cognitive impairment (MCI) conversion to Alzheimers disease (AD), and genetic risk for AD. Using the European Medical Information Framework (EMI... |
36,789,917 | Examining the Lancet Commission risk factors for dementia using Mendelian randomisation. | Dementia incidence is increasing across the globe and currently there are no disease-modifying pharmaceutical treatments. The Lancet Commission on dementia identified 12 modifiable risk factors which explain 40% of dementia incidence. However, whether these associations are causal in nature is unclear. To examine the m... |
36,789,662 | Novel benzothiazole derivatives as multitargeted-directed ligands for the treatment of Alzheimers disease. | Neurodegenerative diseases such as Alzheimers disease (AD) are multifactorial with several different pathologic mechanisms. Therefore, it is assumed that multitargeted-directed ligands (MTDLs) which interact with different biological targets relevant to the diseases, might offer an improved therapeutic alternative than... |
36,789,483 | Predicting amyloid PET and tau PET stages with plasma biomarkers. | Staging the severity of Alzheimers disease pathology using biomarkers is useful for therapeutic trials and clinical prognosis. Disease staging with amyloid and tau PET has face validity however, this would be more practical with plasma biomarkers. Our objectives were, first, to examine approaches for staging amyloid an... |
36,788,803 | Illuminating neurodegeneration a future perspective on near-infrared spectroscopy in dementia research. | Dementia presents a global healthcare crisis, and neuroimaging is the main method for developing effective diagnoses and treatments. Yet currently, there is a lack of sensitive, portable, and low-cost neuroimaging tools. As dementia is associated with vascular and metabolic dysfunction, near-infrared spectroscopy (NIRS... |
36,788,617 | Plasma extracellular vesicles reveal early molecular differences in amyloid positive patients with early-onset mild cognitive impairment. | In the clinical course of Alzheimers disease (AD) development, the dementia phase is commonly preceded by a prodromal AD phase, which is mainly characterized by reaching the highest levels of Aβ and p-tau-mediated neuronal injury and a mild cognitive impairment (MCI) clinical status. Because of that, most AD cases are ... |
36,788,598 | Asymmetric dysregulation of glutamate dynamics across the synaptic cleft in a mouse model of Alzheimers disease. | Most research on glutamate spillover focuses on the deleterious consequences of postsynaptic glutamate receptor overactivation. However, two decades ago, it was noted that the glial coverage of hippocampal synapses is asymmetric astrocytic coverage of postsynaptic sites exceeds coverage of presynaptic sites by a factor... |
36,788,477 | A multimodal deep learning model to infer cell-type-specific functional gene networks. | Functional gene networks (FGNs) capture functional relationships among genes that vary across tissues and cell types. Construction of cell-type-specific FGNs enables the understanding of cell-type-specific functional gene relationships and insights into genetic mechanisms of human diseases in disease-relevant cell type... |
36,788,318 | Effects of presenilin-1 familial Alzheimers disease mutations on γ-secretase activation for cleavage of amyloid precursor protein. | Presenilin-1 (PS1) is the catalytic subunit of γ-secretase which cleaves within the transmembrane domain of over 150 peptide substrates. Dominant missense mutations in PS1 cause early-onset familial Alzheimers disease (FAD) however, the exact pathogenic mechanism remains unknown. Here we combined Gaussian accelerated m... |
36,788,306 | Activity patterns are associated with fractional lifespan, memory, and gait speed in aged dogs. | Maintaining an active lifestyle is considered a hallmark of successful aging. Physical activity significantly reduces the risk of cognitive decline and Alzheimers disease in humans. However, pain and lack of motivation are important barriers to exercise. Dogs are a remarkable model for translational studies in aging an... |
36,788,297 | Investigation of Shared Genetic Risk Factors Between Parkinsons Disease and Cancers. | Epidemiological studies that examined the association between Parkinsons disease (PD) and cancers led to inconsistent results, but they face a number of methodological difficulties. We used results from genome-wide association studies (GWASs) to study the genetic correlation between PD and different cancers to identify... |
36,788,216 | Modifications of the endosomal compartment in fibroblasts from sporadic Alzheimers disease patients are associated with cognitive impairment. | Morphological alterations of the endosomal compartment have been widely described in post-mortem brains from Alzheimers disease (AD) patients and subjects with Down syndrome (DS) who are at high risk for AD. Immunostaining with antibodies against endosomal markers such as Early Endosome Antigen 1 (EEA1) revealed increa... |
36,788,145 | Rare-variant association analysis reveals known and new age-related hearing loss genes. | Age-related (AR) hearing loss (HL) is a prevalent sensory deficit in the elderly population. Several studies showed that common variants increase ARHL susceptibility. Here, we demonstrate that rare-variants play a crucial role in ARHL etiology. We analyzed exome and imputed data from white-European UK Biobank volunteer... |
36,788,058 | A Phenome-wide Association and Mendelian Randomization Study for Alzheimers Disease A Prospective Cohort Study of 502,493 Participants From the UK Biobank. | Considerable uncertainty remains regarding associations of multiple risk factors with Alzheimers disease (AD). We aimed to systematically screen and validate a wide range of potential risk factors for AD. Among 502,493 participants from the UK Biobank, baseline data were extracted for 4171 factors spanning 10 different... |
36,787,752 | Neurodegeneration cell per cell. | The clinical definition of neurodegenerative diseases is based on symptoms that reflect terminal damage of specific brain regions. This is misleading as it tells little about the initial disease processes. Circuitry failures that underlie the clinical symptomatology are themselves preceded by clinically mostly silent, ... |
36,787,643 | A Medicinal Chemistry Perspective on Excitatory Amino Acid Transporter 2 Dysfunction in Neurodegenerative Diseases. | The excitatory amino acid transporter 2 (EAAT2) plays a key role in the clearance and recycling of glutamate - the major excitatory neurotransmitter in the mammalian brain. EAAT2 lossdysfunction triggers a cascade of neurodegenerative events, comprising glutamatergic excitotoxicity and neuronal death. Nevertheless, our... |
36,787,495 | Can mixed circuit training elicit the recommended exercise intensity and energy expenditure in people after stroke | To investigate whether mixed circuit training (MCT) elicits the recommended exercise intensity and energy expenditure in people after stroke, and to establish the between-day reproducibility for the percentages of heart rate reserve (%HRR), oxygen uptake reserve (%VO Seven people aged 58 (12) yr, who previously had a s... |
36,787,364 | Mitochondrial control of microglial phagocytosis by the translocator protein and hexokinase 2 in Alzheimers disease. | Microglial phagocytosis is an energetically demanding process that plays a critical role in the removal of toxic protein aggregates in Alzheimers disease (AD). Recent evidence indicates that a switch in energy production from mitochondrial respiration to glycolysis disrupts this important protective microglial function... |
36,787,293 | Effects of sex and APOE ε4 genotype on brain mitochondrial high-energy phosphates in midlife individuals at risk for Alzheimers disease A 31Phosphorus MR spectroscopy study. | Age, female sex, and APOE epsilon 4 (APOE4) genotype are the three greatest risk factors for late-onset Alzheimers disease (AD). The convergence of these risks creates a hypometabolic AD-risk profile unique to women, which may help explain their higher lifetime risk of AD. Less is known about APOE4 effects in men, alth... |
36,787,221 | Butyrate ameliorates quinolinic acid-induced cognitive decline in obesity models. | Obesity is a risk factor for neurodegenerative disease associated with cognitive dysfunction, including Alzheimers disease. Low-grade inflammation is common in obesity, but the mechanism between inflammation and cognitive impairment in obesity is unclear. Accumulative evidence shows that quinolinic acid (QA), a neuroin... |
36,786,966 | Lactococcus intestinalis sp. nov., a new lactic acid bacterium isolated from intestinal contents in Alzheimers disease mice. | A gram-positive, facultatively anaerobic, and coccoid or ovoid-shaped bacterium designated M2458 |
36,786,778 | Stability of the Aβ42 Peptide in Mixed Solutions of Denaturants and Proline. | Amyloid β-peptide (Aβ) is responsible for the neuronal damage and death of a patient with Alzheimers disease (AD). Aβ42 oligomeric forms are dominant neurotoxins and are related to neurodegeneration. Their different forms are related to various pathological conditions in the brain. We investigated Aβ42 peptides in diff... |
36,786,552 | Phosphorylation at Ser289 Enhances the Oligomerization of Tau Repeat R2. | In tauopathies such as Alzheimers disease (AD), aberrant phosphorylation causes the dissociation of tau proteins from microtubules. The dissociated tau then aggregates into sequent forms from soluble oligomers to paired helical filaments and insoluble neurofibrillary tangles (NFTs). NFTs is a hallmark of AD, while olig... |
36,786,521 | Unsupervised machine learning model to predict cognitive impairment in subcortical ischemic vascular disease. | It is challenging to predict which patients who meet criteria for subcortical ischemic vascular disease (SIVD) will ultimately progress to subcortical vascular cognitive impairment (SVCI). We collected clinical information, neuropsychological assessments, T1 imaging, diffusion tensor imaging, and resting-state function... |
36,786,375 | Multivalent Nanobody Conjugate with Rigid, Reactive Oxygen Species Scavenging Scaffold for Multi-Target Therapy of Alzheimers Disease. | Efficient therapeutic strategies that concurrently target both Aβ aggregation and oxidative stress in the AD microenvironment emerge as a cutting-edge tool to combat the intricate pathogenesis of AD. Here we develop a multivalent nanobody conjugate with rigid, reactive oxygen species (ROS) scavenging scaffold to achiev... |
36,786,288 | I lay awake at night Latino Family Caregivers Experiences Covering Out-of-Pocket Costs when Caring for Someone Living with Dementia. | The financial burden of caregiving has received less research attention than physical and emotional costs. This is especially true for underserved ethnic minorities. Financial strain affects mental and physical health and is unequally distributed across caregivers of different races and ethnicities. While caregivers ov... |
36,786,148 | Does statin use affect amyloid beta deposition and brain metabolism | There are contradictory findings regarding the effect of statin drugs on amyloid β (Aβ) deposition as one of the main hallmarks of Alzheimers disease (AD), along with tau pathology. We aimed to longitudinally investigate the therapeutic and preventive role of statin drugs by examining the brain Aβ deposition and metabo... |
36,785,898 | Adult neurogenesis in the primate hippocampus. | Adult hippocampal neurogenesis (AHN) is crucial for learning, memory, and emotion. Deficits of AHN may lead to reduced cognitive abilities and neurodegenerative disorders, such as Alzheimers disease. Extensive studies on rodent AHN have clarified the developmental and maturation processes of adult neural stemprogenitor... |
36,785,617 | Could exercise hormone irisin be a therapeutic agent against Parkinsons and other neurodegenerative diseases | Parkinsons disease (PD) is the second most common neurodegenerative disease after Alzheimers disease (AD). The pathologic hallmarks of the disease are the loss of dopaminergic neurons of substantia nigra pars compacta and the presence of intraneuronal alpha synuclein (a-syn) aggregates. Clinical features of PD include ... |
36,785,586 | Agent Orange Reviewed Potential Role in Peripheral Neuropathy and Neurodegeneration. | Agent Orange, a dioxin-containing toxin, was used as an herbicide during the Vietnam War. Exposures to Agent Orange were initially linked to birth defects among Vietnamese civilians residing near aerially sprayed regions. Years later, returning South Korean and U.S. Veterans exposed to Agent Orange exhibited increased ... |
36,782,352 | Polygenic risk scores for Alzheimers disease and general cognitive function are associated with measures of cognition in older South Asians from LASI-DAD. | Genome-wide association studies (GWAS) conducted in European ancestry (EA) have identified hundreds of single nucleotide polymorphisms (SNPs) associated with general cognitive function andor Alzheimers disease (AD). The association between these SNPs and cognitive function has not been fully evaluated in populations wi... |
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