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36,800,626 | Adverse reactions and efficacy of camrelizumab in patients with lung adenocarcinoma with high PD-L1 expression A case report. | Immune checkpoint inhibitors have been rapidly developed for lung cancer therapy and major clinical guidelines have recommended them as the optimal first-line treatment for PD-L1-positive advanced lung cancer. Unfortunately, there is a lack of efficient prediction tools for the occurrence of immune-related adverse even... |
36,800,575 | Screening and identification of hub-gene associated with brain metastasis in breast cancer. | The presence of breast cancer in the brain, also known as brain metastasis (BMS), is the primary reason for a bad prognosis in cases of breast cancer. Breast cancer is the most prevalent malignant tumor seen in women in developing nations. At present, there is no effective method to inhibit brain metastasis of breast c... |
36,800,342 | The relationship between radiation dose and bevacizumab-related imaging abnormality in patients with brain tumors A voxel-wise normal tissue complication probability (NTCP) analysis. | Bevacizumab-related imaging abnormality (BRIA), appearing as areas of restricted diffusion on magnetic resonance imaging (MRI) and representing atypical coagulative necrosis pathologically, has been observed in patients with brain tumors receiving radiotherapy and bevacizumab. We investigated the role of cumulative rad... |
36,800,340 | Investigating centrifugal filtration of serum-based FTIR spectroscopy for the stratification of brain tumours. | Discrimination of brain cancer versus non-cancer patients using serum-based attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy diagnostics was first developed by Hands et al with a reported sensitivity of 92.8% and specificity of 91.5%. Cameron et al. then went on to stratifying between spec... |
36,800,124 | Liquid biomarkers in glioma. | An ideal biomarker must meet several parameters to enable its successful adoption however, the nature of glioma makes it challenging to discover valuable biomarkers. While biomarkers require simplicity for clinical implementation, anatomical features and the complexity of the brain make it challenging to perform histol... |
36,799,460 | Hypersomnia and Narcolepsy in 42 Adult Patients with Craniopharyngioma. | To evaluate sleep, sleepiness and excessive need for sleep in patients with craniopharyngioma (a suprasellar tumor which can affect sleep-wake systems). A retrospective study of all adult craniopharyngioma patients referred to the sleep clinic, who received a sleep interview, nocturnal polysomnography, multiple sleep l... |
36,798,872 | Nucleotide-Binding Oligomerization Domain (NOD)-Like Receptor Subfamily C (NLRC) as a Prognostic Biomarker for Glioblastoma Multiforme Linked to Tumor Microenvironment A Bioinformatics, Immunohistochemistry, and Machine Learning-Based Study. | Glioblastoma multiforme (GBM) remains the deadliest primary brain tumor. We aimed to illuminate the role of nucleotide-binding oligomerization domain (NOD)-like receptor subfamily C (NLRC) in GBM. Based on public database data (mainly The Cancer Genome Atlas TCGA), we performed bioinformatics analysis to visually evalu... |
36,798,771 | Frequency and burden of potentially treatable symptoms in glioma patients with stable disease. | Glioma patients experience a multitude of symptoms that negatively affect their health-related quality of life. Symptoms vary greatly across disease phases, and the patients stable phase might be particularly suitable for assessing and treating symptoms. Identifying symptoms and patients needs is a first step toward im... |
36,798,537 | Endothelial Indoleamine-2,3-Dioxygenase-1 is not Critically Involved in Regulating Antitumor Immunity in the Central Nervous System. | The vascular niche of malignant gliomas is a key compartment that shapes the immunosuppressive brain tumor microenvironment (TME). The blood-brain-barrier (BBB) consisting of specialized endothelial cells (ECs) and perivascular cells forms a tight anatomical and functional barrier critically controlling transmigration ... |
36,798,364 | Modulation of GPR133 (ADGRD1) Signaling by its Intracellular Interaction Partner Extended Synaptotagmin 1 (ESYT1). | GPR133 (ADGRD1) is an adhesion G protein-coupled receptor that signals through Gαs and is required for growth of glioblastoma (GBM), an aggressive brain malignancy. The regulation of GPR133 signaling is incompletely understood. Here, we use proximity biotinylation proteomics to identify ESYT1, a Ca |
36,798,058 | Possible association between minor head injury and intratumoral hemorrhage A metastatic brain tumor from thyroid carcinoma. | A 78-year-old woman presented after a fall and injury in the left forehead. She had undergone surgery for papillary thyroid carcinoma 14 years prior and breast carcinoma 7 years prior. The patient had exhibited uneventful postoperative courses without relapse or metastasis. Anticoagulants or antiplatelet agents were no... |
36,797,543 | PatchResNet Multiple Patch Division-Based Deep Feature Fusion Framework for Brain Tumor Classification Using MRI Images. | Modern computer vision algorithms are based on convolutional neural networks (CNNs), and both end-to-end learning and transfer learning modes have been used with CNN for image classification. Thus, automated brain tumor classification models have been proposed by deploying CNNs to help medical professionals. Our primar... |
36,797,502 | Reciprocal interactions between innate immune cells and astrocytes facilitate neuroinflammation and brain metastasis via lipocalin-2. | Brain metastasis still encompass very grim prognosis and therefore understanding the underlying mechanisms is an urgent need toward developing better therapeutic strategies. We uncover the intricate interactions between recruited innate immune cells and resident astrocytes in the brain metastatic niche that facilitate ... |
36,797,491 | Single-cell mapping of combinatorial target antigens for CAR switches using logic gates. | Identification of optimal target antigens that distinguish cancer cells from normal surrounding tissue cells remains a key challenge in chimeric antigen receptor (CAR) cell therapy for tumors with intratumoral heterogeneity. In this study, we dissected tissue complexity to the level of individual cells through the cons... |
36,797,287 | Inhibition of inflammatory microglia by dietary fiber and short-chain fatty acids. | Microglia play a vital role maintaining brain homeostasis but can also cause persistent neuroinflammation. Short-chain fatty acids (SCFAs) produced by the intestinal microbiota have been suggested to regulate microglia inflammation indirectly by signaling through the gut-brain axis or directly by reaching the brain. Th... |
36,797,159 | Comparison between the HyperArc™ technique and the CyberKnife® technique for stereotactic treatment of brain metastases. | The purpose of this study was to compare the planimetric capacities between HyperArc™-based stereotactic radiosurgery and robotic radiosurgery system-based planning using CyberKnife® M6 for single and multiple cranial metastases. We evaluated 51 treatment plans for cranial metastases, including 30 patients with a singl... |
36,797,033 | Reconstruction of the Corticospinal Tract in Patients with Motor-Eloquent High-Grade Gliomas Using Multilevel Fiber Tractography Combined with Functional Motor Cortex Mapping. | Tractography of the corticospinal tract is paramount to presurgical planning and guidance of intraoperative resection in patients with motor-eloquent gliomas. It is well-known that DTI-based tractography as the most frequently used technique has relevant shortcomings, particularly for resolving complex fiber architectu... |
36,796,938 | Lessons learned from evolving frameworks in adult glioblastoma. | Glioblastoma (GBM) is the most common and aggressive malignant adult brain tumor. Significant effort has been directed to achieve a molecular subtyping of GBM to impact treatment. The discovery of new unique molecular alterations has resulted in a more effective classification of tumors and has opened the door to subty... |
36,796,878 | PKR induces TGF-β and limits oncolytic immune therapy. | Mammalian cells have developed multiple intracellular mechanisms to defend against viral infections. These include RNA-activated protein kinase (PKR), cyclic GMP-AMP synthase and stimulation of interferon genes (cGAS-STING) and toll-like receptor-myeloid differentiation primary response 88 (TLR-MyD88). Among these, we ... |
36,796,652 | Hypoxic glioma cell-secreted exosomal circ101491 promotes the progression of glioma by regulating miR-125b-5pEDN1. | Hypoxia and exosomes play important roles in the occurrence and development of glioma. While circRNAs are involved in biological processes of various tumors, the mechanism underlying exosome-dependent regulatory effects of circRNAs on the progression of glioma under hypoxia is unclear. Results suggested that circ101491... |
36,796,622 | circPKD2 inhibits the glioma cell proliferation, invasion and glycolytic metabolism through regulating the miR-1278 LATS2 axis. | Glioma is the most prevalent brain tumor with a poor prognosis. Circular RNA (circ) (PKD2) has been identified as a potential tumor suppressor. However, the effect of circPKD2 on glioma has been unknown. circPKD2 expression in glioma and its potential targets were analyzed by bioinformatics methods, qRT-PCR, dual lucif... |
36,796,416 | Placement of a Catheter into the Transverse Sinus in Monitoring Intracranial Lesions A Technical Note. | High intracranial pressure (ICP) can be induced by stroke, brain trauma, and brain tumor, and lead to cerebral injury. Monitoring the blood flow of a damaged brain is important for detecting intracranial lesions. Blood sampling is a better way to monitor changes in brain oxygen and blood flow than computed tomography p... |
36,796,338 | Changes in Inflammatory Markers in Clinical High Risk of Developing Psychosis. | Immune alterations are associated with the progression of psychosis. However, there are few studies designed to longitudinally measure inflammatory biomarkers during psychotic episodes. We aimed to assess changes in biomarkers from the prodromal phase to psychotic episodes in individuals with clinical high risk (CHR) o... |
36,796,229 | Chronotherapy in Glioblastoma State of the art and future perspectives. | Circadian rhythms regulate various processes in the human body, including drug metabolism. Chronotherapy optimizes treatment timing based on the circadian rhythm of the individual patient, such that the treatment efficacy is maximized, and adverse effects are minimized. It has been explored in different cancers with va... |
36,796,177 | Deriving quantitative information from multiparametric MRI via Radiomics Evaluation of the robustness and predictive value of radiomic features in the discrimination of low-grade versus high-grade gliomas with machine learning. | Analysis pipelines based on the computation of radiomic features on medical images are widely used exploration tools across a large variety of image modalities. This study aims to define a robust processing pipeline based on Radiomics and Machine Learning (ML) to analyze multiparametric Magnetic Resonance Imaging (MRI)... |
36,795,877 | Imaging of Brain Tumors. | This article focuses on neuroimaging as an essential tool for diagnosing brain tumors and monitoring response to treatment. Neuroimaging is useful at all stages of brain tumor care. Technologic advances have improved the clinical diagnostic capability of neuroimaging as a vital complement to history, examination, and p... |
36,795,522 | Protective Effect of Erythromycin Pre-adaptation on Focal Cerebral Ischemia in Rats and its Changes in TNF-α and nNOS. | Ischemic stroke accounts for 85% of all types of stroke. Ischemic preconditioning can provide protection against cerebral ischemic injury. Erythromycin can induce ischemic preconditioning in brain tissue. The study intended to investigate the protective effects of erythromycin preconditioning on infarct volume after fo... |
36,795,488 | Sorting-nexin-10 sustains platelet-derived growth factor receptor signaling in glioblastoma stem cells via endosomal protein sorting. | Glioblastoma is the most malignant primary brain tumor for which the prognosis remains dismal even with aggressive surgical, medical, and radiation therapies. Glioblastoma stem cells (GSCs) promote therapeutic resistance and cellular heterogeneity due to their self-renewal properties and capacity for plasticity. To und... |
36,794,762 | The HOPX and BLBP landscape and gliogenic regions in developing human brain. | Outer radial glial cells (oRGs) give rise to neurons and glial cells and contribute to cell migration and expansion in developing neocortex. HOPX has been described as a marker of oRGs and possible actor in glioblastomas. Recent years evidence points to spatiotemporal differences in brain development which may have imp... |
36,794,424 | Growth hormone and childhood-onset craniopharyngioma When to initiate growth hormone replacement therapy | Craniopharyngioma is a benign brain tumour with frequent local recurrence or progression after treatment. Growth hormone replacement therapy (GHRT) is prescribed in children with growth hormone deficiency due to childhood-onset craniopharyngioma. To evaluate whether shorter time delay of GHRT initiation after childhood... |
36,793,838 | Not All Monstrous Cells Indicate Glioblastoma A Neuropathological Case Report of Pleomorphic Xanthoastrocytoma Misdiagnoses As Giant Cell Glioblastoma. | Pleomorphic xanthoastrocytoma (PXA) is a rare central nervous system malignant neoplasm with a relatively favorable prognosis. As PXA histologically presents with large, multinucleated neoplastic cells, its principal differential diagnosis is giant cell glioblastoma (GCGBM). While there is a significant overlap between... |
36,793,735 | Evaluation of immunotherapy efficacy in gynecologic cancer. | Various immunotherapies have demonstrated remarkable success over the past few decades, and have been approved for the treatment of different cancer types. However, patient responses to immunotherapy are variable, and approximately 50% of cases are refractory to these agents. Tumor biomarker-based stratification of cas... |
36,793,384 | Molecular Epidemiology and Treatment Patterns of Patients With EGFR Exon 20-Mutant NSCLC in the Precision Oncology Era The European EXOTIC Registry. | Real-world evidence regarding molecular epidemiology and management patterns of patients with EGFR exon-20 mutated, advanced NSCLC outside the context of clinical trials is lacking. We created a European registry for patients with advanced EGFR exon 20-mutant NSCLC diagnosed from January 2019 to December 2021. Patients... |
36,793,330 | Regulation of the p53‑mediated ferroptosis signaling pathway in cerebral ischemia stroke (Review). | Stroke is one of the most threatening diseases worldwide, particularly in countries with larger populations it is associated with high morbidity, mortality and disability rates. As a result, extensive research efforts are being made to address these issues. Stroke can include either hemorrhagic stroke (blood vessel rup... |
36,793,327 | null | Dietary fat strongly influences the intestinal mucosal barrier, which protects against invading pathogenic bacteria. A high-fat diet (HFD) compromises the integrity of epithelial tight junctions (TJs) and reduces mucin production, leading to intestinal barrier disruption and metabolic endotoxemia. It has been shown tha... |
36,793,113 | Efficacy and safety of lenalidomide in HIV-associated cryptococcal meningitis patients with persistent intracranial inflammation an open-label, single-arm, prospective interventional study. | Patients with human immunodeficiency virus-associated cryptococcal meningitis (HIV-CM) have persistent intracranial inflammation despite negative cerebrospinal fluid (CSF) fungal cultures after optimal treatment for CM, which could be devastating for the central nervous system. However, a definitive treatment strategy ... |
36,793,008 | Comparison of the preoperative diagnostic accuracy of BIPSS versus MRI for Cushing disease a single-centre experience. | Cushing disease (CD) arises due to a pituitary corticotroph adenoma, which is the most common cause of Cushing syndrome (CS). Bilateral inferior petrosal sinus sampling (BIPSS) is a safe method for differentiating CD from ectopic adrenocorticotropic hormone (ACTH)-dependent CS. Enhanced high-resolution magnetic resonan... |
36,792,972 | Neurotrophins are they involved in immune tolerance in pregnancy | In this review, an attempt was made to substantiate the possibility for neurotrophins to be involved in the development of immune tolerance based on data accumulated on neurotrophin content and receptor expression in the trophoblast and immune cells, in particular, in natural killer cells. Numerous research results are... |
36,792,805 | Safety and anti-tumor activity of lisavanbulin administered as 48-hour infusion in patients with ovarian cancer or recurrent glioblastoma a phase 2a study. | Lisavanbulin (BAL101553) is the prodrug of avanbulin (BAL27862), a microtubule-destabilizing agent. The goal of this study (NCT02895360) was to characterize the safety, tolerability and antitumor activity of lisavanbulin administered as a 48-hour intravenous (IV) infusion at the recommended Phase 2 dose (RP2D) of 70 mg... |
36,792,756 | PRMT6-CDC20 facilitates glioblastoma progression via the degradation of CDKN1B. | PRMT6, a type I arginine methyltransferase, di-methylates the arginine residues of both histones and non-histones asymmetrically. Increasing evidence indicates that PRMT6 plays a tumor mediator involved in human malignancies. Here, we aim to uncover the essential role and underlying mechanisms of PRMT6 in promoting gli... |
36,792,722 | Advances in NK cell therapy for brain tumors. | Despite advances in treatment regimens that comprise surgery, chemotherapy, and radiation, outcome of many brain tumors remains dismal, more so when they recur. The proximity of brain tumors to delicate neural structures often precludes complete surgical resection. Toxicity and long-term side effects of systemic therap... |
36,792,323 | Cognitive and neuroimaging outcomes in individuals with benign and low-grade brain tumours receiving radiotherapy a protocol for a prospective cohort study. | Radiation-induced cognitive decline (RICD) occurs in 50%-90% of adult patients 6 months post-treatment. In patients with low-grade and benign tumours with long expected survival, this is of paramount importance. Despite advances in radiation therapy (RT) treatment delivery, better understanding of structures important ... |
36,792,292 | Oncogenic potential of PIK3CD in glioblastoma is exerted through cytoskeletal proteins PAK3 and PLEK2. | The Class I |
36,792,291 | High levels of TIMP1 are associated with increased extracellular matrix stiffness in isocitrate dehydrogenase 1-wild type gliomas. | Glioma progression is accompanied with increased tumor tissue stiffness, yet the underlying mechanisms are unclear. Herein, we employed atomic force microscopy analysis to show that tissue stiffness was higher in isocitrate dehydrogenase (IDH)-wild type gliomas than IDH-mutant gliomas. Bioinformatic analyses revealed t... |
36,791,763 | Patient-Reported Outcome Measures in Chemotherapy-Induced Peripheral Neurotoxicity Defining Minimal and Clinically Important Changes. | Chemotherapy-induced peripheral neurotoxicity (CIPN) is a common complication of cancer treatment that produces functional disability. Increasingly, patient-reported outcome measures (PROMs) are used to assess CIPN, providing a broader symptom perspective than clinician-graded scales. Understanding when a reported chan... |
36,791,685 | Patterns of care and survival in cancer patients with brain metastases receiving immune checkpoint inhibitors. | Immune checkpoint inhibitors (ICI) have become a mainstay of treatment for different cancer types. The purpose of this study was to evaluate patterns of care and overall survival after diagnosis of brain metastases in patients managed with ICI as component of care. Retrospective cohort study. Fifty patients were includ... |
36,791,582 | The PTEN-associated immune prognostic signature reveals the landscape of the tumor microenvironment in glioblastoma. | Glioblastoma (GBM) is a common brain tumor with a complex and diverse tumor microenvironment (TME). As PTEN mutation is the most common mutation in GBM, we aimed to investigate how PTEN mutation regulates the immune response in GBM TME and thus affects the prognosis of GBM patients. In this study, we conducted a compre... |
36,791,318 | Clinical Features and Outcomes of Triple-Negative Breast Cancer Among Latin American Adolescents and Young Adults Compared to Middle-Aged and Elder Females A Cohort Analysis Over 15 Years. | null |
36,791,206 | Small-molecule toosendanin reverses macrophage-mediated immunosuppression to overcome glioblastoma resistance to immunotherapy. | T cell-based immunotherapy holds promise for treating solid tumors, but its therapeutic efficacy is limited by intratumoral immune suppression. This immune suppressive tumor microenvironment is largely driven by tumor-associated myeloid cells, including macrophages. Here, we report that toosendanin (TSN), a small-molec... |
36,790,207 | Risk of Tract Seeding Following Laser Interstitial Thermal Therapy for Brain Tumors. | The management of intracranial oncological disease remains a significant challenge despite advances in systemic cancer therapy. Laser interstitial thermal therapy (LITT) represents a novel treatment for local control of brain tumors through photocoagulation with a stereotactically implanted laser fiber. Because the use... |
36,789,775 | Prevalence and Therapeutic Implications of Clonal Hematopoiesis of Indeterminate Potential in Young Patients With Stroke. | Undetermined stroke etiology hampers optimal secondary prevention in a large proportion of young patients. We explored whether genetic screening for clonal hematopoiesis of indetermined potential (CHIP), a novel risk factor for stroke, could identify patients with myeloid precursor lesions or covert myeloid neoplasm re... |
36,789,426 | Feasibility of a virtual reality intervention targeting distress and anxiety symptoms in patients with primary brain tumors Interim analysis of a phase 2 clinical trial. | null |
36,789,262 | Investigating cellular heterogeneity at the single-cell level by the flexible and mobile extrachromosomal circular DNA. | Extrachromosomal circular DNA (eccDNA) is a special class of DNA derived from linear chromosomes. It coexists independently with linear chromosomes in the nucleus. eccDNA has been identified in multiple organisms, including Homo sapiens, and has been shown to play important roles relevant to tumor progression and drug ... |
36,789,113 | null | Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor with poor prognosis and high potential of dispersion to other brain tissues in adult. Effective and modern choices of treatment including chemotherapy with alkylating agents marginally extend survival of GBM. However, alkylating agents c... |
36,789,023 | Collagen deposition within brain metastases is associated with leptomeningeal failure after cavity-directed radiosurgery. | Leptomeningeal failure (LMF) represents a devastating progression of disease following resection of brain metastases (BrM). We sought to identify a biomarker at time of BrM resection that predicts for LMF using mass spectrometry-based proteomic analysis of resected BrM and to translate this finding with histochemical a... |
36,788,905 | Laser Interstitial Thermal Therapy for the Treatment of a Pineal Region Glioma Through an Infratentorial Approach A Case Report. | Laser interstitial thermal therapy (LITT) is a minimally invasive surgical option for the treatment of brain tumors introduced in 1983. The innovative technique was welcomed for its ability to access deep-seated supratentorial and posterior cranial fossa lesions. Surgical approaches to pineal region tumors are challeng... |
36,788,834 | Clinical Features and Neurosurgical Management of Metastatic Intradural Extramedullary Renal Cell Carcinoma. | Intradural extramedullary metastasis of renal cell carcinoma is exceedingly uncommon, and only 19 cases have been reported in the literature. It is thought to metastasize from the kidneys through venous networks or along nerves and may also spread from brain metastases through cerebrospinal fluid. We present a 52-year-... |
36,788,768 | Tumor Habitat Analysis Using Longitudinal Physiological MRI to Predict Tumor Recurrence After Stereotactic Radiosurgery for Brain Metastasis. | It is difficult to predict the treatment response of tissue after stereotactic radiosurgery (SRS) because radiation necrosis (RN) and tumor recurrence can coexist. Our study aimed to predict tumor recurrence, including the recurrence site, after SRS of brain metastasis by performing a longitudinal tumor habitat analysi... |
36,788,686 | Diffuse leptomeningeal glioneuronal tumors A case series of five patients with parenchymal forms and an analysis of the diagnostic challenges, treatment options, and outcomes. | Diffuse leptomeningeal glioneuronal tumors (DL-GNT) are rare glioneuronal neoplasms with oligodendroglioma-like cells. These tumors can present as a dominant intracranial mass or as a solitary spinal cord mass without leptomeningeal involvement. In this study, we aimed to determine the magnetic resonance imaging and hi... |
36,788,610 | Dosimetric and clinical analysis of pseudo-progression versus recurrence after hypo-fractionated radiotherapy for brain metastases. | The main challenge in follow-up duration of patients with brain metastases after stereotactic radiotherapy is to distinguish between pseudo-progression and tumor recurrence. The objective of this study is to retrospectively analyze the predictive factors. The study included 123 patients with enlarged brain metastases a... |
36,788,560 | Swin Unet3D a three-dimensional medical image segmentation network combining vision transformer and convolution. | Semantic segmentation of brain tumors plays a critical role in clinical treatment, especially for three-dimensional (3D) magnetic resonance imaging, which is often used in clinical practice. Automatic segmentation of the 3D structure of brain tumors can quickly help physicians understand the properties of tumors, such ... |
36,788,350 | EWI2 and its relatives in Tetraspanin-enriched membrane domains regulate malignancy. | Experimental studies on immunoglobulin superfamily (IgSF) member EWI2 reveal that it suppresses a variety of solid malignant tumors including brain, lung, skin, and prostate cancers in animal models and inhibits tumor cell movement and growth in vitro. While EWI2 appears to support myeloid leukemia in mouse models and ... |
36,788,314 | Influence of surgical position and registration methods on clinical accuracy of navigation systems in brain tumor surgery. | The aim of this study was to evaluate the influence of skin distortion due to surgical positioning on the clinical accuracy of the navigation system. The distance errors were measured in four fiducial markers (anterior, posterior, right, and left of the head) after the registration of the navigation system. The distanc... |
36,788,155 | Utility of real-time polymerase chain reaction for the assessment of CDKN2A homozygous deletion in adult-type IDH-mutant astrocytoma. | The World Health Organization Classification of Tumors of the Central Nervous System 5th Edition (WHO CNS5) introduced a newly defined astrocytoma, IDH-mutant grade 4, for adult diffuse glioma classification. One of the diagnostic criteria is the presence of a CDKN2AB homozygous deletion (HD). Here, we report a robust ... |
36,788,073 | Identifying SOX17 as a Sensitive and Specific Marker for Ovarian and Endometrial Carcinomas. | Similar to PAX8, SOX17 was recently identified as a master transcription factor of ovarian cancer based on RNA sequencing data. We explored SOX17 utility in diagnosing ovarian tumors and other gynecologic tumors. We systematically evaluated SOX17 expression on tissue microarrays of 398 ovarian tumors of various types, ... |
36,787,930 | Neurocristic cutaneous hamartoma of the scalp with disseminated melanocytic nevi. | We report a newborn with neurocristic cutaneous hamartoma of the scalp. He was delivered at term via caesarean section due to a previous scar and presented at the neonatal unit on the fifth day with giant congenital nevi on the scalp and disseminated melanocytic nevi throughout the body. The MRI scan of the brain showe... |
36,787,748 | Glioma epileptiform activity and progression are driven by IGSF3-mediated potassium dysregulation. | Seizures are a frequent pathophysiological feature of malignant glioma. Recent studies implicate peritumoral synaptic dysregulation as a driver of brain hyperactivity and tumor progression however, the molecular mechanisms that govern these phenomena remain elusive. Using scRNA-seq and intraoperative patient ECoG recor... |
36,787,514 | Cascade-Responsive 2-DG Nanocapsules Encapsulate aV-siCPT1C Conjugates to Inhibit Glioblastoma through Multiple Inhibition of Energy Metabolism. | Aerobic glycolysis is the primary energy supply mode for glioblastoma (GBM) cells to maintain growth and proliferation. However, due to the metabolic reprogramming of tumor cells, GBM can still produce energy through fatty acid oxidation (FAO) and amino acid metabolism after blocking this metabolic pathway. In addition... |
36,786,867 | Central neurocytomas research trends, most cited papers, and scientometrics analysis to date. | Central neurocytoma is the most common primary intraventricular tumor in adults being classified by the World Health Organization (WHO) as a benign grade II tumor with a good prognosis. Given the recent advances with regard to this tumor, a bibliometric analysis was due to study the future direction of research for neu... |
36,786,286 | Anti-tumour and radiosensitising effects of PARP inhibitor on cervical cancer xenografts. | This study evaluated the radiosensitising effect of niraparib a poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitor on HeLa cervical cancer cells in nude mice and explored its possible mechanism. Twenty-four 3-5-week-old female BALBc nude mice, inoculated with HeLa cells into the right hind leg, were randoml... |
36,785,962 | Astrocytoma with 1p19q codeletion. | Using the example of a recurrent tumor with a 10-year follow-up, the authors show that mutation of the На примере рецидивирующей опухоли с 10-летним катамнезом авторы показывают, что мутация генов |
36,785,960 | Microsatellite instability and DNA mismatch repair deficiency detection in tumors of various sites. | Microsatellite instability, which is caused by a deficiency in the DNA unpaired nucleotide repair system, is an important pathogenetic event for some tumors. In addition, the detection of this molecular feature becomes an independent prognostic factor in the course of the disease and a predictor for the appointment of ... |
36,785,959 | Causes of death in the Moscow region according to medical death certificates. | Determination of the leading causes of death based on data from primary medical death certificates (MDCs) depending on the place of death. From the electronic database of the Main Department of the Civil Registry Office of the Moscow Region (the USR registry office system) for 2021, all cases were selected in which dis... |
36,782,354 | The association of Medicaid expansion and pediatric cancer overall survival. | Medicaid eligibility expansion, though not directly applicable to children, has been associated with improved access to care in children with cancer, but associations with overall survival are unknown. Data for children ages 0 to 14 years diagnosed with cancer from 2011 to 2018 were queried from central cancer registri... |
36,782,314 | CNS tumor with EP300BCOR fusion discussing its prevalence in adult population. | The Central Nervous System (CNS) tumor with BCOR internal tandem duplication (ITD) has recently been added as a novel embryonal histomolecular tumor type to the 2021 World Health Organization (WHO) Classification of CNS Tumors. In addition, other CNS tumors harboring a BCORBCORL1 fusion, which are defined by a distinct... |
36,781,939 | Efficient 3D light-sheet imaging of very large-scale optically cleared human brain and prostate tissue samples. | The ability to image human tissue samples in 3D, with both cellular resolution and a large field of view (FOV), can improve fundamental and clinical investigations. Here, we demonstrate the feasibility of light-sheet imaging of 5 cm |
36,781,906 | Tanshinone IIA-loaded nanoparticles and neural stem cell combination therapy improves gut homeostasis and recovery in a pig ischemic stroke model. | Impaired gut homeostasis is associated with stroke often presenting with leaky gut syndrome and increased gut, brain, and systemic inflammation that further exacerbates brain damage. We previously reported that intracisternal administration of Tanshinone IIA-loaded nanoparticles (Tan IIA-NPs) and transplantation of ind... |
36,781,873 | Multiple plasma membrane reporters discern LHFPL5 region that blocks trafficking to the plasma membrane. | The mechano-electrical transduction (MET) channel of the inner ear receptor cells, termed hair cells, is a protein complex that enables our senses of hearing and balance. Hair cell MET requires an elaborate interplay of multiple proteins that form the MET channel. One of the MET complex components is the transmembrane ... |
36,781,714 | PCSK9 Inhibition Reduces Depressive like Behavior in CUMS-Exposed Rats Highlights on HMGB1RAGETLR4 Pathway, NLRP3 Inflammasome Complex and IDO-1. | Ample evidence has pointed to a close link between cardiovascular diseases (CVD) and depression. Inflammatory pathways including the high-mobility-group-box-1 protein, receptor-for-advanced-glycation-end-products and toll-like-receptor-4 (HMGB1RAGETLR4) and nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3... |
36,781,309 | Clinically predictive baseline labs for post-operative outcomes of brain tumors using NSQIP database. | This study was performed to assess the effect of baseline Preoperative Laboratory Values (PLV) on post-operative Brain Tumor Resection (BTR) outcomes in a large national registry. We extracted data from the National Surgical Quality Improvement Program (NSQIP) database for BTR patients 2015-2019 (n 3 0,951). Uni- and m... |
36,780,892 | Risk factors and the nomogram model for intraoperatively acquired pressure injuries in children with brain tumours A retrospective study. | This study aimed to investigate the clinical features and incidence of Intraoperatively Acquired Pressure Injuries (IAPIs) of brain tumours in children, to screen the risk factors and to establish a nomogram model for making prevention strategies against the development of IAPIs. Clinical data of 628 children undergoin... |
36,780,766 | Characterization of Central Nervous System Clinico-Genomic Outcomes in ALK-Positive Non-Small Cell Lung Cancer Patients with Brain Metastases Treated with Alectinib. | Highly effective brain-penetrant ALK-targeted tyrosine kinase inhibitors (TKIs) have been developed for the management of NSCLC patients with brain metastases (BM). Local therapy (LT) such as SRS or therapeutic craniotomy is increasingly being deferred for such patients. Herein we report detailed patient- and lesion-le... |
36,780,628 | ANALYSIS OF DISABILITY AND REHABILITATION NEEDS OF THE ANTI-TERRORIST OPERATIONJOINT FORCES OPERATION PARTICIPANTS IN UKRAINE. | The purpose of the study - to conduct an analysis of the disability of ATOJFO participants in 2014-2021 with a detailed comparative analysis of data of 2021 and determination of the needs of the mentioned contingent in rehabilitation devices. Operational information was collected according to the statistic form of ATOO... |
36,780,531 | An HLA-GSPAG9STAT3 axis promotes brain metastases. | Brain metastases (BM) are the most common brain neoplasm in adults. Current BM therapies still offer limited efficacy and reduced survival outcomes, emphasizing the need for a better understanding of the disease. Herein, we analyzed the transcriptional profile of brain metastasis initiating cells (BMICs) at two distinc... |
36,780,420 | Leucine-rich repeats containing 4 protein (LRRC4) in memory, psychoneurosis, and glioblastoma. | Leucine-rich repeats containing 4 (LRRC4, also named Netrin-G ligand 2 NGL-2) is a member of the NetrinGs ligands (NGLs) family. As a gene with relatively high and specific expression in brain, it is a member of the leucine-rich repeat superfamily and has been proven to be a suppressor gene for gliomas, thus being invo... |
36,780,245 | ACT Semi-supervised Domain-adaptive Medical Image Segmentation with Asymmetric Co-Training. | Unsupervised domain adaptation (UDA) has been vastly explored to alleviate domain shifts between source and target domains, by applying a well-performed model in an unlabeled target domain via supervision of a labeled source domain. Recent literature, however, has indicated that the performance is still far from satisf... |
36,779,940 | Two rare cases of pituitary apoplexy in adult females a tricky diagnosis. | We reported two cases of women who suffered from a rare case of pituitary apoplexy, rare and potentially fatal clinical condition due to a hemorrhagic infarction of the pituitary gland due to a pre-existing macroadenoma. The onset of symptoms is often insidious and includes generic symptoms such as headache, vomiting, ... |
36,779,058 | Comprehensive conservative treatment for multiple metastases of skull osteosarcoma A case report. | Skull osteosarcoma is relatively rare, and it is difficult to be diagnosed according to medical history and imaging examination due to the complex structure and diverse components of the brain. Consequently, there is only a limited number of patients who can undergo neoadjuvant chemotherapy before the operation. Althou... |
36,778,762 | The Cancer Driver Genes IDH1 and IDH2 and CD204 in WHO-Grade 4 Astrocytoma Crosstalk Between Cancer Metabolism and Tumour Associated Macrophage Recruitment in Tumour Microenvironment. | IDH1 and IDH2 are hotspot mutations commonly identified in WHO-grade 4 astrocytomas. Their association with TAMs has never been investigated. We aim to explore the crosstalk between the IDH12 mutation metabolic effect and TAMs in tumour microenvironment and how this relationship affects the tumour recurrence. The study... |
36,778,417 | Grey matter reshaping of language-related regions depends on tumor lateralization. | A brain tumor in the left hemisphere can decrease language laterality as assessed with fMRI. However, it remains unclear whether or not this decreased language laterality is associated with a structural reshaping of the grey matter, particularly within the language network. Here, we examine if the disruption of languag... |
36,778,129 | An Overview The Diversified Role of Mitochondria in Cancer Metabolism. | Mitochondria are intracellular organelles involved in energy production, cell metabolism and cell signaling. They are essential not only in the process of ATP synthesis, lipid metabolism and nucleic acid metabolism, but also in tumor development and metastasis. Mutations in mtDNA are commonly found in cancer cells to p... |
36,777,618 | Decoding the Role of MDM2 as a Potential Ubiquitin E3 Ligase and Identifying the Therapeutic Efficiency of Alkaloids against MDM2 in Combating Glioblastoma. | Glioblastomas (GBMs) represent the most aggressive form of brain tumor arising from the malignant transformation of astrocytes. Despite various advancements, treatment options remain limited to chemotherapy and radiotherapy followed by surgery giving an overall survival of 14-15 months. These therapies are somewhere re... |
36,776,876 | RUNX1CD44 axis regulates the proliferation, migration, and immunotherapy of gliomas A single-cell sequencing analysis. | Glioma is one of the most common, primary, and lethal adult brain tumors because of its extreme aggressiveness and poor prognosis. Several recent studies relevant to the immune function of CD44, a transmembrane glycoprotein as a significant hyaluronic acid receptor, have achieved great success, revealing the critical r... |
36,776,860 | Generation of mesenchymal stromal cells from urine-derived iPSCs of pediatric brain tumor patients. | Human induced pluripotent stem cells (iPSCs) provide a virtually inexhaustible source of starting material for next generation cell therapies, offering new opportunities for regenerative medicine. Among different cell sources for the generation of iPSCs, urine cells are clinically relevant since these cells can be repe... |
36,776,343 | Brain tumours in the time of COVID-19 An online survey on patients disease experience in one Italian region. | Since the outbreak, in 2019, of COVID-19, the world has experienced marked changes in daily habits, partly reflecting the exceptional social restrictions and health measures adopted to contain the disease. All these measures significantly affected not only peopless daily lives and psychological well-being but also the ... |
36,776,329 | Epidemiological characteristics, clinical presentations, and prognoses of pediatric brain tumors Experiences of national center for childrens health. | We aimed to describe the epidemiological characteristics, clinical presentations, and prognoses in a national health center for children. From January 2015 to December 2020, 484 patients aged 0-16 years, who were diagnosed with brain tumors and received neurosurgery treatment, were enrolled in the study. Pathology was ... |
36,776,328 | BASP1 is a prognostic biomarker associated with immunotherapeutic response in head and neck squamous cell carcinoma. | Immunotherapy is effective in a subset of head and neck squamous cell carcinoma (HNSCC). However, the unfavorable response rate and inadequate biomarkers for stratifying patients have primarily limited its clinical application. Considering transcriptional factors (TFs) play essential roles in regulating immune activity... |
36,776,324 | A population-based study of synchronous distant metastases and prognosis in patients with PDAC at initial diagnosis. | Cancer of the pancreas is a life-threatening condition and has a high distant metastasis (DM) rate of over 50% at diagnosis. Therefore, this study aimed to determine whether patterns of distant metastases correlated with prognosis in pancreatic ductal adenocarcinoma (PDAC) with metastatic spread, and build a novel nomo... |
36,776,301 | Addressing blood-brain-tumor-barrier heterogeneity in pediatric brain tumors with innovative preclinical models. | Brain tumors represent the leading cause of disease-related mortality and morbidity in children, with effective treatments urgently required. One factor limiting the effectiveness of systemic therapy is the blood-brain-barrier (BBB), which limits the brain penetration of many anticancer drugs. BBB integrity is often co... |
36,776,293 | Advances in the intraoperative delineation of malignant glioma margin. | Surgery plays a critical role in the treatment of malignant glioma. However, due to the infiltrative growth and brain shift, it is difficult for neurosurgeons to distinguish malignant glioma margins with the naked eye and with preoperative examinations. Therefore, several technologies were developed to determine precis... |
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