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36,826,983 | Desires for Individual- and Interpersonal-Level Patient Portal Use for HIV Prevention Among Urban Sexual Minority Men Cross-sectional Study. | Gay, bisexual, and other sexual minority men have expressed the acceptability of patient portals as tools for supporting HIV prevention behaviors, including facilitating disclosure of HIV and other sexually transmitted infection (STIHIV) laboratory test results to sex partners. However, these studies, in which Black or... |
36,826,980 | HIV Epidemiology, Care, and Treatment Outcomes Among Student and Nonstudent Youths Living With HIV in Southwest China Between 1996 and 2019 Historical Cohort Study. | Nearly one-third of new HIV infections occurred among youth in 2019 worldwide. Previous studies suggested that student youths living with HIV and nonstudent youths living with HIV might differ in some risk factors, transmission routes, HIV care, and disease outcomes. This study aimed to compare the HIV epidemic, diseas... |
36,826,779 | Racial Differences in Social Determinants of Health and Outcomes Among HispanicLatino Persons with HIV-United States, 2015-2020. | HispanicLatino people with HIV (PWH) experience disparities in health outcomes compared with other racial and ethnic groups. Disaggregated data based on race for HispanicLatino PWH in the United States are rarely reported, potentially masking inequities. The Medical Monitoring Project (MMP) is a complex sample survey o... |
36,826,626 | Safer Sex Negotiation Among Ghanaian Women in Sexual Unions Does Womens Household Decision-Making Capacity Matter | Womens ability to negotiate for safer sex has been found to be dependent on their household decision making power. However, there is paucity of studies investigating the association between womens household decision making power and safer sex negotiation in Ghana. Thus, we examined the association between womens househ... |
36,826,350 | HIV Infection Indicator Disease-Based Active Case Finding in a University Hospital Results from the SHOT Project. | In 2014, UNAIDS launched renewed global targets for HIV control to achieve by 2025, known as the three 95 95% of people living with HIV (PWH) diagnosed, of which 95% are receiving treatment, of which 95% are on sustained virological suppression. In Italy, new HIV diagnoses have been steadily decreasing since 2012. Howe... |
36,826,348 | Long-Term Survivors in a Cohort of People Living with HIV Diagnosed between 1985 and 1994 Predictive Factors Associated with More Than 25 Years of Survival. | Although the mortality rate among individuals diagnosed during the pre-Highly Active Antiretroviral Treatment era has been substantial, a considerable number of them survived. Our study aimed to evaluate the prevalence of HIV long-term survivors in a cohort of People Living with HIV diagnosed between 1985 and 1994 and ... |
36,826,167 | Empowering Tennessee Pharmacists to Initiate PrEP Using Collaborative Pharmacy Practice Agreements. | The uptake of Pre-Exposure Prophylaxis (PrEP) has revolutionized the fight against the Human Immunodeficiency Virus (HIV) epidemic. Consistent obstacles remain that have influenced the slow uptake of PrEP in the United States of America (USA). In order to address these barriers, pharmacists must be included in the disp... |
36,826,156 | Pathogenesis, Diagnostic Challenges, and Risk Factors of Potts Disease. | Tuberculosis (TB) prevalence is increasing in developed nations and continuing to cause significant mortality in low- and middle-income countries. As a result of the uptick in cases, there also exists an increased prevalence of extrapulmonary TB. TB is caused by |
36,826,057 | Vaccine- and Breakthrough Infection-Elicited Pre-Omicron Immunity More Effectively Neutralizes Omicron BA.1, BA.2, BA.4 and BA.5 Than Pre-Omicron Infection Alone. | Since the emergence of SARS-CoV-2 Omicron BA.1 and BA.2, several Omicron sublineages have emerged, supplanting their predecessors. Here we compared the neutralization of Omicron sublineages BA.1, BA.2, BA.4 and BA.5 by human sera collected from individuals who were infected with the ancestral B.1 (D614G) strain, who we... |
36,825,949 | Prevalence of Congenital Infections in Newborns and Universal Neonatal Hearing Screening in Santa Catarina, Brazil. | to verify the frequency of congenital infections in newborns and their possible associations with the universal-neonatal-hearing-screening (UNHS) results, and evaluate a reference UNHS service in the Unified Health System ( Historical cohort study with data analysis of newborns attending prestigious hearing-health SUS ... |
36,825,608 | What are the risk factors for death among children with pneumonia in low- and middle-income countries A systematic review. | Knowledge of the risk factors for and causes of treatment failure and mortality in childhood pneumonia is important for prevention, diagnosis, and treatment at an individual and population level. This review aimed to identify the most important risk factors for mortality among children aged under ten years with pneumon... |
36,825,555 | Longitudinal impact of stressful life events on HIV-related risk and psychosocial problems among MSM in Chennai and Mumbai, India. | Studies show that stressful life events (SLE) (e.g., discrimination, financial problems) can lead to psychosocial problems and exacerbate condomless anal sex (CAS) without protection via pre-exposure prophylaxis (PrEP) among men who have sex with men. However, few studies have examined this relationship among men who h... |
36,825,536 | HSV-2 prevalence and association with inflammatory cytokines among sexual and gender minorities (SGM) living with and without HIV-1 from Lagos, Nigeria. | Herpes simplex virus type 2 (HSV-2) is common globally and contributes significantly to the risk of acquiring HIV-1, yet these two sexually transmitted infections (STIs) have not been sufficiently characterized for sexual and gender minorities (SGM) across sub-Saharan Africa. To help fill this gap, we performed a retro... |
36,825,522 | Immune cell cross talk in the establishment of HIV-1 latency. | Revolutionary progress in combinational antiretroviral therapy (cART) has transformed Human Immunodeficiency Virus (HIV) infection into a chronic manageable disease yet there exists an uneasy truce between the virus and the immune cells, where inflammation is limited but infection continues to fester from latent reserv... |
36,825,507 | The influence of HIV and its treatment on Hypertensive Disorders Of Pregnancy (HDP) in women from a low to middle income country. | To establish a potential relationship between HDP and HIV infection METHODS This cross sectional observational study involving 300 women with HDP was undertaken from September 2018 to February 2019, in a regional hospital in Durban, South Africa, a setting with a background HIV prevalence of 45% among pregnant women. A... |
36,825,492 | Isothermal nucleic acid amplification technology in HIV detection. | Nucleic acid testing for HIV plays an important role in the early diagnosis and monitoring of antiretroviral therapy outcomes in HIV patients and HIV-infected infants. Currently, the main molecular diagnostic methods employed are complex, time-consuming, and expensive to operate in resource-limited areas. Isothermal nu... |
36,825,369 | System mapping with adolescents Using group model building to map the complexity of obesity. | Public health research and practice is increasingly employing systems thinking to help grapple with complex issues, from obesity to HIV treatment. At the same time, there is growing recognition that to address a given problem it is essential collaborate with those most at risk of or affected by it. Group model building... |
36,825,290 | Study on molecular mechanisms of CD4 dependency and independency of HIV-1 gp120. | Different HIV-1 strains have different antibody neutralization phenotypes (or CD4-dependencies). However, the molecular mechanisms underlying these differences remain to be elucidated. In this study, we constructed gp120 structural models from the CD4-dependent, neutralization-resistant JR-FL strain and the CD4-indepen... |
36,825,123 | Cochrane corner community-level interventions to increase access to food in low- and middle-income countries. | Food insecurity and hunger is a continuing problem in Africa, with access to food being critical to address it. Community-level interventions may help to increase access to food, specifically, nutritious food. We highlight a Cochrane review that assessed community level interventions aiming to increase access to nutrit... |
36,825,120 | Evaluation of the HIV drug resistance surveillance system in Mozambique, 2017-2018. | In the past ten years, the prevalence of primary Human Immunodeficiency Virus (HIV) drug resistance has ranged from zero to 25%, with higher and increasing rates in countries with access to antiretroviral therapy (ART), a specific case in Mozambique. World Health Organization (WHO) recommended that countries implement ... |
36,825,049 | Presynaptic Hemiparkinsonism Following Cerebral Toxoplasmosis Case Report and Literature Review. | Cerebral toxoplasmosis (CTx) is a central nervous system opportunistic infection with variable neurological manifestations. Although tropism of We report a human immunodeficiency virus-positive patient who developed a complex MD featuring unilateral tremor combined with parkinsonism and dystonia following an acute epis... |
36,825,014 | Assessment of anti-CD20 antibody pre-treatment for augmentation of CAR-T cell therapy in SIV-infected rhesus macaques. | During chronic HIV and SIV infections, the majority of viral replication occurs within lymphoid follicles. In a pilot study, infusion of SIV-specific CD4-MBL-CAR-T cells expressing the follicular homing receptor, CXCR5, led to follicular localization of the cells and a reduction in SIV viral loads in rhesus macaques. H... |
36,824,983 | Extracellular vesicle-Serpine-1 affects neural progenitor cell mitochondrial functions and synaptic density modulation by amyloid beta and HIV-1. | Brain endothelial extracellular vesicles carrying amyloid beta (EV-Aβ) can be transferred to neural progenitor cells (NPCs) leading to NPC dysfunction. However, the events involved in this EV-mediated Aβ pathology are unclear. EV-proteomics studies identified Serpine-1 (plasminogen activator inhibitor 1, PAI-1) as a ma... |
36,824,925 | The association between childhood adversity and the conserved transcriptional response to adversity (CTRA) in sexual minority men. | Adverse childhood experiences (ACES) increase risk for mental and physical health disorders in adulthood, particularly in individuals from sexual and ethnic minority groups. The effects of ACES on health may be mediated by the immune system. The exact mechanisms by which an environmental exposure, such as childhood adv... |
36,824,916 | Measuring Stigma Associated with Hepatitis B Virus Infection in Sierra Leone Validation of an Abridged Berger HIV Stigma Scale. | Stigma associated with hepatitis B virus (HBV) is common in endemic countries however instruments are lacking to accurately measure HBV-related stigma. We therefore aimed to develop and validate a concise instrument for measuring perceived HBV-related stigma in Sierra Leone. We enrolled 220 people living with HBV (PWHB... |
36,824,869 | HIV-1 interaction with an O-glycan-specific bacterial lectin enhances virus infectivity and cell-to-cell viral transfer. | While bacterial dysbiosis has been associated with increased HIV-1 transmission risk, little is known about direct associations between HIV-1 and bacteria. This study evaluated HIV-1 interactions with bacteria through glycan-binding lectins that affect virus infectivity. The Streptococcal Siglec-like lectin SLBR-N, whi... |
36,824,802 | Ionic Liquid Coating-Driven Nanoparticle Delivery to the Brain Applications for NeuroHIV. | Delivering cargo to the central nervous system (CNS) remains a pharmacological challenge. For infectious diseases such as HIV, the CNS acts as a latent reservoir that is inadequately managed by systemic antiretrovirals (ARTs). ARTs thus cannot eradicate HIV, and given CNS infection, patients experience an array of neur... |
36,824,660 | The impact of carceral churn and healthcare organizations on HIVAIDS incidence in Arkansas. | •Penal and healthcare institutions generate and mitigate community-level health inequality, respectively.•Arkansas Counties with high prison churn and disadvantage have higher rates of HIVAIDS.•Hospital density moderates effect of prison churn on incidence of HIVAIDS. |
36,824,558 | Acute HIV Presenting With Unilateral Facial Nerve Paralysis A Case Report. | Cranial nerve VII palsy is one of the most common cranial nerve pathologies seen in clinical practice. In the vast majority of cases, the cause is thought to be idiopathic and is also referred to as Bells palsy. These cases are normally self-limiting and often treated with a short course of corticosteroids for symptom ... |
36,824,383 | Hormone Prescription and HIV ScreeningPreventive Practices Among Clinicians Providing Care for Transgender Individuals. | Through a survey-based approach, we sought to investigate regional differences in gender-affirming hormone therapy (GAHT) prescribing practices, as well as HIV screening and prevention practices among clinicians providing care to transgender individuals. Our survey was disseminated between December 2019 and January 202... |
36,824,245 | The Pattern of Tuberculosis in Iran A National Cross-Sectional Study. | Despite of the remarkable achievement in control of tuberculosis, it is still a challenging health problem in Iran. Success in any health program depends on monitor the diseases epidemiology and finding the gaps. We aimed to describe the epidemiological profile of TB patients in Iran to find the gaps in the TB program ... |
36,824,000 | Superwoman schema uncovering repercussions of coping strategies used among Black women at high risk for HIV. | The Superwomen Schema (SWS) describes a social framework that encompasses the role that many Black women adopt in response to chronic stress, financial pressures, and an intersection of oppression. Woods-Giscombé (Superwoman Schema African American Womens Views on Stress, Strength, and Health. Qualitative Health Resear... |
36,823,951 | Cultural Repertoires and Situated Selections as an Alternative Framework to Hegemonic Masculinities Findings From Eswatini. | Since the 1980s studies on men have frequently utilized Connells framework of hegemonic masculinities. We critically appraise this framework in the context of a population-based HIV pre-exposure prophylaxis study in Eswatini. Our findings highlight that men confidently show variation in their behavior and choices, whic... |
36,823,688 | Emergomyces pasteurianus in Man Returning to the United States from Liberia and Review of the Literature. | A 65-year-old man with HIV sought treatment for fever, weight loss, and productive cough after returning to the United States from Liberia. Fungal cultures grew Emergomyces pasteurianus, and the patients health improved after beginning voriconazole. We describe the clinical case and review the literature, treatment, an... |
36,823,632 | Incidence and risk factors of hypertriglyceridemia in males with human immunodeficiency virus who are treated with combination antiretroviral therapy a retrospective cohort study. | Hypertriglyceridemia is associated with subclinical atherosclerosis and vascular inflammation even when low-density lipoprotein cholesterol levels are normal. However, few cohort studies on hypertriglyceridemia have been conducted in males with higher susceptibility to human immunodeficiency virus (HIV)-related deterio... |
36,823,600 | Public health determinants of child malaria mortality a surveillance study within Siaya County, Western Kenya. | Malaria deaths among children have been declining worldwide during the last two decades. Despite preventive, epidemiologic and therapy-development work, mortality rate decline has stagnated in western Kenya resulting in persistently high child malaria morbidity and mortality. The aim of this study was to identify publi... |
36,823,596 | SARS-CoV-2 antibody prevalence, correlates, and access to harm reduction services among people who inject drugs living with and without HIV and their partners in Kenya. | In sub-Saharan Africa many people who inject drugs (PWID) are living with undiagnosed or untreated HIV and experience high levels of poverty and conditions that can contribute to worse outcomes from SARS-CoV-2 infection. Identifying the burden of SARS-CoV-2 infection in marginalized populations like PWID may contribute... |
36,823,550 | Applying mathematical modelling to estimate the impact of COVID-19-related VMMC service disruptions on new HIV infections in Zimbabwe. | The COVID-19 pandemic has overwhelmed health systems with knock on effects on diagnosis, treatment, and care. To mitigate the impact, the government of Zimbabwe enforced a strict lockdown beginning 30 March 2020 which ran intermittently until early 2021. In this period, the Ministry of Health and Childcare strategicall... |
36,823,533 | Nurses reflections on caring for sexual and gender minorities pre-post stigma reduction training in Uganda. | Men who have sex with men (MSM) and transgender women (TGW) have a significant HIV burden worldwide. Data from eight countries across sub-Saharan Africa found a pooled HIV prevalence of 14% among MSM and 25% among TGW. Stigma and discrimination among healthcare providers are barriers to healthcare access by these popul... |
36,823,496 | Tuberculosis Preventive Therapy among Persons Living with HIV, Uganda, 2016-2022. | During October 2016-March 2022, Uganda increased tuberculosis (TB) preventive therapy coverage among persons living with HIV from 0.6% to 88.8%. TB notification rates increased from 881.1 to 972.5 per 100,000 persons living with HIV. Timely TB screening, diagnosis, and earlier treatment should remain high priorities fo... |
36,823,283 | Effectiveness and safety of tenofovir alafenamide in children and adolescents living with HIV a systematic review. | Tenofovir alafenamide (TAF) is approved for paediatric use in fixed-dose combination tablets, but efficacy and safety data in children are limited. We conducted a systematic review on the efficacyeffectiveness and safety of TAF in infants, children and adolescents living with HIV. We searched MEDLINE, Embase, the Cochr... |
36,823,280 | A Census Tract-Level Examination of HIV Care Outcomes and Social Vulnerability Among BlackAfrican American, HispanicLatino, and White Adults in the Southern United States, 2018. | We examined the association between social vulnerability and HIV diagnoses, linkage to HIV medical care, and viral suppression among adults in the Southern U.S. Data from CDCs National HIV Surveillance System (NHSS) were used to determine census tract-level HIV diagnosis rates and percentages of persons linked to care ... |
36,822,839 | Open-Label, Drug-Drug Interaction Study Between the HIV-1 Maturation Inhibitor GSK3640254 and a Metabolic Probe Cocktail in Healthy Participants. | GSK3640254 (GSK254) is an HIV-1 maturation inhibitor with pharmacokinetics (PK) supporting once-daily dosing. GSK254 will be co-administered with cytochrome P450 enzyme substrates and drug transporters, including other antiretrovirals, in people living with HIV-1 (PLWH). In this open-label study, healthy participants r... |
36,822,704 | Antiretrovirals for Human Immunodeficiency Virus Treatment and Prevention in Pregnancy. | Safe and effective antiretroviral medications are needed during pregnancy to reduce maternal morbidity and mortality associated with untreated human immunodeficiency virus (HIV) infection and to prevent viral transmission to the infant. Pharmacokinetic studies have helped inform the appropriate dosing of antiretroviral... |
36,822,173 | Mapping the interplay between NK cells and HIV therapeutic implications. | Although highly effective at durably suppressing plasma HIV-1 viremia, combination antiretroviral therapy (ART) treatment regimens do not eradicate the virus, which persists in long-lived CD4 T cells. This latent viral reservoir serves as a source of plasma viral rebound following treatment interruption, thus requiring... |
36,822,019 | Immune recovery among Romanian HIVAIDS patients receiving darunavirritonavir or darunavircobicistat regimens in cART management A three-year study. | Approximately two-thirds of Romanian HIV patients were parenterally infected with the F subtype of HIV in early childhood. They are now in the context of immunological aging, with immunosuppression posing an additional challenge in developing the most effective and well-tolerated regimens. The risk of an improper immun... |
36,822,011 | Pathways connecting socioeconomic marginalization and overdose A qualitative narrative synthesis. | This qualitative narrative synthesis sought to identify pathways connecting socioeconomic marginalization (SEM) and overdose for people who use drugs. We included studies with qualitative examination of SEM and fatal and non-fatal overdose published in English between 2000 and 2021. Studies were systematically identifi... |
36,821,952 | Comparative efficacy and acceptability of non-pharmacological interventions for depression in people living with HIV A systematic review and network meta-analysis. | Treatment for depression in people living with HIV has increasingly turned to non-pharmacological treatments due to the adverse reactions of pharmacotherapy. However, it remains unclear which non-pharmacological treatment is the most effective and acceptable for depression in people living with HIV. To compare and rank... |
36,821,669 | Deadly mpox risk in people with untreated HIV comes into view. | Analysis of hundreds of patients suggests mpox is a different disease in immunocompromised patients. |
36,821,649 | Supernatural beliefs, religious affiliations, and HIV testing among recently arrived Asian-born men who have sex with men in Australia. | HIV testing rates among recently arrived (≤5 years) Asian-born men who have sex with men (MSM) in Australia remain suboptimal. Research indicates that belief in supernatural determinants of health (supernatural beliefs) may be an important barrier to greater HIV test uptake. We examined potential associations between s... |
36,821,576 | Emergency department experiences of people who use drugs who left or were discharged from hospital against medical advice. | People who use drugs (PWUD) frequent emergency departments at a higher rate than the general population, and experience a greater frequency of soft tissue infections, pneumonia, and chronic conditions such as, HIVAIDs and hepatitis C. This population has distinct health care considerations (e.g. withdrawal management) ... |
36,821,550 | Increased uptake of tuberculosis preventive therapy (TPT) among people living with HIV following the 100-days accelerated campaign A retrospective review of routinely collected data at six urban public health facilities in Uganda. | Tuberculosis preventive therapy (TPT) effectively decreases rates of developing active tuberculosis disease in people living with HIV (PLHIV) who are at increased risk. The Uganda Ministry of Health launched a 100-day campaign to scale-up TPT in PLHIV in July 2019. We sought to examine the effect of the campaign on tre... |
36,821,538 | HIV virologic response, patterns of drug resistance mutations and correlates among adolescents and young adults A cross-sectional study in Tanzania. | The emergence of HIV drug resistance mutations (DRMs) is of significant threat to achieving viral suppression (VS) in the quest to achieve global elimination targets. We hereby report virologic outcomes and patterns of acquired DRMs and its associated factors among adolescents and young adults (AYA) from a broader HIV ... |
36,821,530 | Maternal biomarkers of endothelial dysfunction and pregnancy outcomes in women with and without HIV in Botswana. | Women living with HIV-1 (WLHIV) are at higher risk of having an adverse birth outcome, but the underlying mechanism(s) are unknown. We hypothesized that HIV-associated endothelial activation could adversely impact placental function and lead to impaired fetal growth or stillbirth. We used stored samples from WLHIV and ... |
36,821,489 | Cryptococcal Meningitis and Clinical Outcomes in Persons with HIV A Global View. | Cryptococcal meningitis (CM) is a major cause of morbidity and mortality in persons with HIV(PWH). Little is known about CM outcomes and availability of diagnostic and treatment modalities globally. This retrospective cohort study investigated CM incidence and all-cause mortality after CM diagnosis in PWH in the IeDEA ... |
36,821,374 | IL15 enhances HIV-1 infection by promoting survival and proliferation of CCR5CD4 T cells. | HIV-1 usually utilize CCR5 as the co-receptor and rarely switches to CXCR4-tropic until late stage of infection. CCR5CD4 T cells are the major virus-producing cells in viremic patients as well as SIV-infected non-human primates. The differentiation of CCR5CD4 T cells is associated with the availability of IL15, which i... |
36,821,362 | Mobile Phone Apps for HIV Prevention Among College-Aged Black Women in Atlanta Mixed Methods Study and User-Centered Prototype. | Black women in college are disproportionately affected by HIV diagnoses. Mobile apps can facilitate the innovative delivery of accurate HIV and sexual and reproductive health information. However, mobile health interventions are severely underused in this population. We aimed to quantitatively and qualitatively explore... |
36,821,021 | Anti-GM-CSF Neutralizing Autoantibodies in Colombian Patients with Disseminated Cryptococcosis. | Cryptococcosis is a potentially life-threatening fungal disease caused by encapsulated yeasts of the genus Cryptococcus, mostly C. neoformans or C. gattii. Cryptococcal meningitis is the most frequent clinical manifestation in humans. Neutralizing autoantibodies (auto-Abs) against granulocyte-macrophage colony-stimulat... |
36,820,957 | Accelerated epigenetic aging in older adults with HIV disease associations with serostatus, HIV clinical factors, and health literacy. | The prevalence of older persons with HIV (PWH) disease has increased considerably in the last 20 years, but our understanding of biological factors of aging and their clinical correlates among PWH remains limited. Study participants were 149 persons aged 50 and older, including 107 PWH and 42 seronegatives. All partici... |
36,820,829 | RELA tunes innate-like interferon IIII responses in human T cells. | In innate immune cells, intracellular sensors such as cGAS-STING stimulate type IIII interferon (IFN) expression, which promotes antiviral defense and immune activation. However, how IFN-IIII expression is controlled in adaptive cells is poorly understood. Here, we identify a transcriptional rheostat orchestrated by RE... |
36,820,639 | Epidemiology of Herpes Zoster in the pre-vaccination era establishing the baseline for vaccination programmes impact in Spain. | BackgroundHerpes zoster (HZ) affects 1 in 3 persons in their lifetime, and the risk of HZ increases with increasing age and the presence of immunocompromising conditions. In Spain, vaccination guidelines were recently updated to include the recommendation of the new recombinant zoster vaccine (RZV) for certain risk gro... |
36,820,627 | Resilience during the COVID-19 pandemic among people living with HIV A cross-sectional study. | This study aims to investigate the factors shaping resilience during the COVID-19 pandemic among people living with HIV (PLWH). A total of 341 participants were included in this cross-sectional study. The online survey included scales of resilience, depression anxiety, loneliness, social support, COVID-19 fear, stress,... |
36,820,471 | Radiation Treatment for Cancer of the Anal Margin. | To identify best treatment practices by examining outcomes of anal margin cancer patients treated with radiotherapy. Relevant literature was compared with 38 patients at our institution treated 1979 to 2019 with curative radiotherapy. Median age was 51. Four patients had T1, 22 had T2, and 12 had T3 disease based on th... |
36,820,315 | Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape From Combination Monoclonal Antibody Treatment in a Person With HIV. | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escape from combination monoclonal antibody treatment is rarely reported. We describe an immunocompromised individual with human immunodeficiency virus and persistent SARS-CoV-2 infection in whom substantial SARS-CoV-2 evolution occurred, including the emerge... |
36,819,986 | Epidemiological characteristics and real-world treatment outcomes of hepatitis C among HIVHCV co-infected patients in Myanmar A prospective cohort study. | In Myanmar, public sector treatment programs for hepatitis C virus (HCV) infection were nonexistent until June 2017. WHO highlights the importance of simplification of HCV service delivery through task-shifting among health workers and decentralization to the primary health care level. Between November 2016 and Novembe... |
36,819,930 | Sexual Health and Sexual Quality of Life Among Individuals With Spinal Cord Injury in Latin America. | Sexual changes are an area of primary concern for individuals with spinal cord injury (SCI) and their partners, but the topic has gone largely unexplored in the research literature. This study examined how individuals with SCI in Latin America experience their sexuality and what issues they and their partners face in t... |
36,819,810 | Achieving the cancer moonshot in Africa. | For decades now, the United States (US) has been a leading contributor in global health with the government, academic institutions, foundations, non-profits and industry investing and partnering with African countries, as seen with the US Presidents Emergency Plan for AIDS Relief (PEPFAR) program. Now as more people su... |
36,819,710 | null | Human immunodeficiency virus (HIV) is an infectious virus that depletes the CD4 |
36,819,650 | Malignant Syphilis A Rare Case of Early Secondary Syphilis in an Immunocompetent Patient. | Early malignant syphilis is an uncommon form of secondary syphilis and characterized by pleomorphic multiple round-to-oval papules, some with necrosis, and associated with systemic signs and symptoms. Usually seen in immunosuppressed patients, mainly those infected with HIV, it can also be observed in immunocompetent p... |
36,819,328 | Complex Case Management of Mycobacterium Tuberculosis Extrapulmonary Manifestation to the Right Sacroiliac Joint. | While Mycobacterium tuberculosis is a common bacterial pathogen that infects the respiratory system, especially in endemic regions, it may uncommonly manifest in other organ systems, such as the nervous, gastrointestinal, or musculoskeletal systems. Sacroiliac joint infections are rare, and only 1%-5% of all infections... |
36,819,158 | HIV-associated Burkitt lymphoma in the combination antiretroviral therapy era Real-world outcomes and prognostication. | We performed a retrospective study to analyze the clinical characteristics and outcomes of human immunodeficiency virus-associated Burkitts lymphoma in Chongqing University Cancer Hospital, southwest China, from March 2012 to February 2022. In the entire cohort, the median age was 36 years (range, 28-60 years), and mor... |
36,819,143 | Prevalence and risk factors for subclinical atherosclerosis amongst adults living with HIV in University of Abuja Teaching Hospital, Gwagwalada. | Subclinical atherosclerosis characterizes cardiovascular diseases (CVD), and Human Immunodeficiency Virus (HIV) infection and antiretroviral therapy (ART) are identified risk factors for atherosclerosis. Meanwhile, data on HIV and atherosclerosis in Nigeria are limited. We sought to estimate the prevalence of subclinic... |
36,818,610 | Benign lymphoepithelial cyst of parotid gland without human immunodeficiency virus infection A case report. | Benign lymphoepithelial cyst (BLEC) of the parotid gland is a rare benign embryonic-dysplastic cystic tumor in the anterolateral neck that occurs most commonly in human immunodeficiency virus (HIV)-positive adults and rarely in non-acquired immune deficiency syndrome patients. The main presentation is a slow-growing, p... |
36,818,564 | HIV Nef Expression Down-modulated GFAP Expression and Altered Glutamate Uptake and Release and Proliferation in Astrocytes. | HIV infection of astrocytes leads to restricted gene expression and replication but abundant expression of HIV early genes Tat, Nef and Rev. A great deal of neuroHIV research has so far been focused on Tat protein, its effects on astrocytes, and its roles in neuroHIV. In the current study, we aimed to determine effects... |
36,818,418 | Using Twitter Data Analysis to Understand the Perceptions, Awareness, and Barriers to the Wide Use of Pre-Exposure Prophylaxis in the United States. | User-generated social media posts such as tweets can provide insights about the publics perception, cognitive, and behavioral responses to health-related issues. Pre-Exposure Prophylaxis (PrEP) is one of the most effective ways to reduce the risk of HIV infection. However, its utilization is low in the US, especially a... |
36,818,238 | Epidemiology of herpes simplex virus type 2 in Europe systematic review, meta-analyses, and meta-regressions. | Herpes simplex virus type 2 (HSV-2) infection is a globally prevalent, life-long, sexually transmitted infection. This study characterized HSV-2 seroprevalence in Europe for various at-risk populations and proportions of HSV-2 detection in genital ulcer disease (GUD) and in genital herpes. Data on neonatal herpes and H... |
36,818,031 | A cross-sectional study on the prevalence of HIV and hepatitis B virus co-infection among students of a tertiary institution in Ekiti State, Southwest Nigeria. | Nigeria aims to eradicate public-health threats such as HIVAIDS and hepatitis B virus (HBV) by 2030. However, to achieve the short- and medium-term response target, and end the epidemic by 2030, there is the need to monitor and estimate the population level of HIV and HBV epidemic trends to boost the countrys strategic... |
36,817,921 | Knowledge domain and emerging trends in HIV-MTB co-infection from 2017 to 2022 A scientometric analysis based on VOSviewer and CiteSpace. | Co-infection with |
36,817,894 | Efficacy of a comprehensive strategy for the detection and treatment of hepatitis C infection in a population attending addiction centers. | The burden hepatitis C infection in people with history or current drug use suppose a high risk of hepatic complications and transmission infectious disease. This population is poor linked to heath system and is difficult to achieve them and support treatment because they have high rates of lost follow-up. Our aim was ... |
36,817,747 | null | We performed a systematic review of published cases. We describe 6 new cases of PCPCOVID-19 coinfection. Among our cases (n 6) and those in the literature (n 69) with available data, the median age (interquartile range IQR) was 59 (44-77) years (n 38), 72% (4765) were male, and the mortality rate was 30.9% (2168). Long... |
36,817,447 | Antibody Fc-chimerism and effector functions When IgG takes advantage of IgA. | Recent advances in the development of therapeutic antibodies (Abs) have greatly improved the treatment of otherwise drug-resistant cancers and autoimmune diseases. Antibody activities are mediated by both their Fab and the Fc. However, therapeutic Abs base their protective mechanisms on Fc-mediated effector functions r... |
36,817,441 | Persistence of spike-specific immune responses in BNT162b2-vaccinated donors and generation of rapid | The BNT162b2 mRNA-based vaccine has shown high efficacy in preventing COVID-19 infection but there are limited data on the types and persistence of the humoral and T cell responses to such a vaccine. Here, we dissect the vaccine-induced humoral and cellular responses in a cohort of six healthy recipients of two doses o... |
36,817,429 | Genome-wide association study of the age of onset of type 1 diabetes reveals HTATIP2 as a novel T cell regulator. | Type 1 diabetes, a disorder caused by autoimmune destruction of pancreatic insulin-producing cells, is more difficult to manage when it presents at a younger age. We sought to identify genetic correlates of the age of onset by conducting the first genome-wide association study (GWAS) treating the age of first diagnosis... |
36,817,421 | Aortic aneurysms and markers of platelet activation, hemostasis, and endothelial disruption in people living with HIV. | People living with HIV (PLWH) are at twice the risk of developing cardiovascular diseases and have more than four times higher odds of aortic aneurysm (AA) than the uninfected population. However, biomarkers of AA in PLWH are yet to be discovered. We aimed to investigate whether circulating biomarkers reflecting platel... |
36,817,287 | NELL1-Positive HIV-Associated Lupus-Like Membranous Nephropathy with Spontaneous Remission. | Kidney biopsy findings in patients with human immunodeficiency virus (HIV) are diverse, and optimal therapy for the various immune complex diseases in the setting of HIV is unknown. A man with well-controlled HIV developed nephrotic range proteinuria, and kidney biopsy revealed lupus-like glomerulonephritis with a pred... |
36,817,157 | Case report Savolitinib induced severe adverse reactions resembling septic shock in an HIV-1-positive patient with advanced non-small cell lung cancer. | Savolitinib, a small-molecule inhibitor of the receptor tyrosine kinase mesenchymal-epithelial transition (MET) factor, was approved for the treatment of non-small cell lung cancer (NSCLC) by the China National Medical Products Administration in June 2021. Its safety for NSCLC treatment has been confirmed in several pr... |
36,817,137 | Clofazimine for the treatment of tuberculosis. | Shorter (6-9 months), fully oral regimens containing new and repurposed drugs are now the first-choice option for the treatment of drug-resistant tuberculosis (DR-TB). Clofazimine, long used in the treatment of leprosy, is one such repurposed drug that has become a cornerstone of DR-TB treatment and ongoing trials are ... |
36,817,078 | Missed opportunities for diagnosis of HIV in the emergency department using non-risk-based testing strategy. | The objective of this study was to identify the number of missed opportunities (MO) for human immunodeficiency virus (HIV) diagnoses within our emergency departments (EDs) and assess any significant associated patient characteristics. Following current Centers for Disease Control guidelines, an opt-out HIV screening pr... |
36,816,973 | Chemo-immunotherapy for metastatic non-squamous NSCLC in a patient with HIV infection A case report. | Activity and safety data of chemo-immunotherapy for patients with metastatic NSCLC and known HIV infection are still limited, since HIV-positive patients were generally excluded from clinical trials. Here we report the case of a metastatic NSCLC patient with HIV infection and undetectable viral load treated with first-... |
36,816,763 | Critical gaps in knowledge and implementation of recommendations by the US Preventive Services Task Force. | The United States Preventive Services Task Force (USPSTF) has issued 31 recommendations applicable to non-pregnant adults. We hypothesized variability in knowledge and implementation of these recommendations among US family medicine resident physicians. We performed two electronic surveys a local survey, and then a nat... |
36,816,720 | Adverse perinatal outcomes associated with antiretroviral therapy in women living with HIV A systematic review and meta-analysis. | Maternal HIV infection is associated with an increased risk of adverse perinatal outcomes. The World Health Organization (WHO) recommends immediate initiation of lifelong antiretroviral therapy (ART) for all people living with HIV, including pregnant women living with HIV (WLHIV). We aimed to assess the risk of adverse... |
36,816,427 | HIV-Associated Nephropathy in 2022. | HIV-associated nephropathy (HIVAN) is a renal parenchymal disease that occurs exclusively in people living with HIV. It is a serious kidney condition that may possibly lead to end-stage kidney disease, particularly in the HIV-1 seropositive patients. The African-American population has increased susceptibility to this ... |
36,816,348 | Change in body weight and risk of hypertension after switching from efavirenz to dolutegravir in adults living with HIV evidence from routine care in Johannesburg, South Africa. | The integrase strand transfer inhibitor (INSTI) dolutegravir is recommended in World Health Organization guidelines, but is associated with weight gain. We evaluated weight change in patients switching from efavirenz to dolutegravir in first-line antiretroviral therapy (ART) in Johannesburg, South Africa. We conducted ... |
36,815,832 | Characterization of the Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Conformational States on Infectious Virus Particles. | Human immunodeficiency virus (HIV-1) entry into cells involves triggering of the viral envelope glycoprotein (Env) trimer (gp120gp41 |
36,815,783 | The HIV paradox perinatal mortality is lower in HIV-positive mothers. A field case-control study in Ethiopia. | Sub-Saharan African countries have the highest perinatal mortality rates. Although HIV is certainly a risk factor for perinatal death, ART programmes have been associated with better outcomes. We aimed to investigate how maternal HIV affects perinatal mortality. We carried out a nested case-control study at the Saint L... |
36,815,489 | Epidemiology of herpes simplex virus type 2 in the Middle East and North Africa Systematic review, meta-analyses, and meta-regressions. | Herpes simplex virus type 2 (HSV-2) infection is a prevalent, sexually transmitted infection with poorly characterized prevalence in the Middle East and North Africa (MENA) region. This study characterized HSV-2 epidemiology in MENA. The systematic review was guided by the Cochrane Collaboration Handbook and findings w... |
36,815,406 | Radioimmunotherapy for the treatment of infectious diseases a comprehensive update. | Corona Virus Disease of 2019 (COVID-19) pandemic has renewed interest in monoclonal antibodies for treating infectious diseases. During last two decades experimental data has been accumulated showing the potential of radioimmunotherapy (RIT) of infectious diseases. In addition, COVID-19 pandemic has created a novel lan... |
36,815,334 | The testing imperative Why the US EHE needs to renew efforts to expand HIV testing in clinical and community-based settings. | Data from several modeling studies demonstrate that large-scale increases in HIV testing across settings with a high burden of HIV may produce the largest incidence reductions to support the US Ending the HIV Epidemic (EHE) initiatives goal of reducing new HIV infections 90% by 2030. Despite US Centers for Disease Cont... |
36,815,177 | Neuromeningeal cryptococcosis in an HIV-negative patient with pulmonary tuberculosis in the Infectious and tropical diseases department of the University teaching hospital Point G of Bamako, Mali. | Neuromeningeal cryptococcosis and pulmonary tuberculosis are respectively serious mycotic and bacterial infections occurring in a subject regardless of its HIV serological status. We report here a case of neuromeningeal cryptococcosis associated with pulmonary tuberculosis and malnutrition in an HIV-seronegative patien... |
36,815,061 | Perceptions of stigma among pulmonary tuberculosis patients in Thailand, and the links to delays in accessing healthcare. | Delay in seeking care increases the morbidity and mortality in tuberculosis (TB) patients and leads to increased likelihood of transmission within the community. Stigmatisation is one of the influencing factors causing delay in accessing healthcare when experiencing symptoms of TB. This study aimed to explore the relat... |
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