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36,896,410 | The Effectiveness of Microdosed Psilocybin in the Treatment of Neuropsychiatric Lyme Disease A Case Study. | Lyme disease can result in severe neuropsychiatric symptoms that may be resistant to treatment. The pathogenesis of neuropsychiatric Lyme disease is associated with autoimmune induced neuroinflammation. This case report describes an immunocompetent male with serologically positive neuropsychiatric Lyme disease who did ... |
36,890,518 | Cannabinoids modulate the microbiota-gut-brain axis in HIVSIV infection by reducing neuroinflammation and dysbiosis while concurrently elevating endocannabinoid and indole-3-propionate levels. | Although the advent of combination anti-retroviral therapy (cART) has transformed HIV into a manageable chronic disease, an estimated 30-50% of people living with HIV (PLWH) exhibit cognitive and motor deficits collectively known as HIV-associated neurocognitive disorders (HAND). A key driver of HAND neuropathology is ... |
36,889,432 | The crosstalk between 5-HT | Schizophrenia is a severe brain disorder that usually produces a lifetime of disability. First generation or typical such as haloperidol and second generation or atypical such as clozapine and risperidone remain the current standard for schizophrenia treatment. In some patients with schizophrenia, antipsychotics produc... |
36,884,348 | A non-hallucinogenic LSD analog with therapeutic potential for mood disorders. | Hallucinations limit widespread therapeutic use of psychedelics as rapidly acting antidepressants. Here we profiled the non-hallucinogenic lysergic acid diethylamide (LSD) analog 2-bromo-LSD (2-Br-LSD) at more than 33 aminergic G protein-coupled receptors (GPCRs). 2-Br-LSD shows partial agonism at several aminergic GPC... |
36,880,919 | Opioid and cannabis co-use The role of opioid use to cope with negative affect. | The opioid epidemic is a significant public health concern, particularly among adults with chronic pain. There are high rates of cannabis co-use among these individuals and co-use is related to worse opioid-related outcomes. Yet, little work has examined mechanisms underlying this relationship. In line with affective p... |
36,880,902 | Screening, brief intervention, and referral to treatment (SBIRT) for cannabis A scoping review. | Screening, brief intervention, and referral to treatment (SBIRT) has been used to change substance use behavior. Despite cannabis being the most prevalent federally illicit substance, we have limited understanding of use of SBIRT for managing cannabis use. This review aimed to summarize the literature on SBIRT for cann... |
36,880,895 | Patterns of polysubstance use and clinical comorbidity among persons seeking substance use treatment An observational study. | Polysubstance use is common among individuals seeking treatment for substance use disorders (SUD). However, we know less about patterns and correlates of polysubstance use among treatment-seeking populations. The current study aimed to identify latent patterns of polysubstance use and associated risk factors in persons... |
36,880,827 | Oral health of recreational ecstasy-users. | In a cross-sectional study, dental records of 149 individuals visiting an Academic Dental Clinic in Amsterdam who reported recreational ecstasy use, defined as no more than twice a week, were systematically analyzed and compared to a group of age- and sex-matched non-drug-users. The parameters retrieved from the dental... |
36,879,096 | Perceived risk of LSD varies with age and race evidence from 2019 United States cross-sectional data. | Psychedelics are being explored for their potential therapeutic benefits across a wide range of psychiatric diagnoses and may usher in a new age in psychiatric treatment. There is stigma associated with these currently illegal substances, and use varies by race and age. We hypothesized that minoritized racial and ethni... |
36,878,892 | Diminished prospective mental representations of reward mediate reward learning strategies among youth with internalizing symptoms. | Adolescent internalizing symptoms and trauma exposure have been linked with altered reward learning processes and decreased ventral striatal responses to rewarding cues. Recent computational work on decision-making highlights an important role for prospective representations of the imagined outcomes of different choice... |
36,876,583 | Investigation of self-treatment with lysergic acid diethylamide and psilocybin mushrooms Findings from the Global Drug Survey 2020. | Growing numbers of people are using psychedelics for personal psychotherapy outside clinical settings, but research on such use is scarce. This study investigated the patterns of use, self-reported outcomes and outcome predictors of psychedelic self-treatment of mental health conditions or specific worriesconcerns in l... |
36,876,146 | Antidepressants A content analysis of healthcare providers tweets. | Antidepressants are the primary treatment for depression, and social support from social media may offer another support route. Whilst Twitter has become an interactive platform for healthcare providers and their patients, previous studies found low engagement of healthcare providers when discussing antidepressants on ... |
36,875,230 | Converging theories on dreaming Between Freud, predictive processing, and psychedelic research. | Dreams are still an enigma of human cognition, studied extensively in psychoanalysis and neuroscience. According to the Freudian dream theory and Solms modifications of the unconscious derived from it, the fundamental task of meeting our emotional needs is guided by the principle of homeostasis. Our innate value system... |
36,874,002 | Rearing behaviour in the mouse behavioural pattern monitor distinguishes the effects of psychedelics from those of lisuride and TBG. | Psychedelics alter consciousness and may have potential for drug development. As psychedelics are likely therapeutically active, it is important to study their effects and mechanisms using preclinical models. Here, we examined the effects of phenylalkylamine and indoleamine psychedelics on locomotor activity and explor... |
36,871,761 | The histamine H3 receptor modulates dopamine D2 receptor-dependent signaling pathways and mouse behaviors. | The histamine H3 receptor (H3R) is highly enriched in the spiny projection neurons (SPNs) of the striatum, in both the D1 receptor (D1R)-expressing and D2 receptor (D2R)-expressing populations. A cross-antagonistic interaction between H3R and D1R has been demonstrated in mice, both at the behavioral level and at the bi... |
36,865,251 | UNRAVELing the synergistic effects of psilocybin and environment on brain-wide immediate early gene expression in mice. | The effects of context on the subjective experience of serotonergic psychedelics have not been fully examined in human neuroimaging studies, partly due to limitations of the imaging environment. Here, we administered saline or psilocybin to mice in their home cage or an enriched environment, immunofluorescently-labeled... |
36,864,260 | Associations of alternative cannabis product use and poly-use with subsequent illicit drug use initiation during adolescence. | Specific cannabis products may differentially increase risk of initiating non-cannabis illicit drug use during adolescence. To determine whether ever- and poly-use of smoked, vaporized, edible, concentrate, or blunt cannabis products are associated with subsequent initiation of non-cannabis illicit drug use. High schoo... |
36,863,501 | The current state of ayahuasca research in animal models A systematic review. | The psychedelic brew ayahuasca is increasingly being investigated for its therapeutic potential. Animal models are essential to investigate the pharmacological effects of ayahuasca since they can control important factors influencing it, such as the set and setting. Review and summarise data available on ayahuasca rese... |
36,861,485 | Psychosocial Factors Associated with Substance Use among Secondary School Students in Ilorin, Nigeria. | Adolescent substance use is a global concern. Identifying factors associated with it can help in preparing prevention programmes. The objectives were to determine the sociodemographic factors associated with substance use and the prevalence of associated psychiatric morbidity among secondary school students in Ilorin. ... |
36,861,394 | Is the Requirement for First-Person Experience of Psychedelic Drugs a Justified Component of a Psychedelic Therapists Training | Recent research offers good reason to think that various psychedelic drugs-including psilocybin, ayahuasca, ketamine, MDMA, and LSD-may have significant therapeutic potential in the treatment of various mental health conditions, including post-traumatic stress disorder, depression, existential distress, and addiction. ... |
36,858,149 | National Institutes of health psilocybin research speaker series State of the science, regulatory and policy landscape, research gaps, and opportunities. | The U.S. National Institutes of Health (NIH) convened a seminal first ever psychedelic drug substance-focused speaker series, from April 22 to June 10, 2021, titled the NIH Psilocybin Research Speaker Series. This speaker series provided evidence-based scientific information to the public and the scientific community. ... |
36,855,876 | Pharmacotherapies for Treatment-Resistant Depression How Antipsychotics Fit in the Rapidly Evolving Therapeutic Landscape. | One in three adults with major depressive disorder (MDD) do not experience clinically significant improvement after multiple sequential courses of antidepressants and have treatment-resistant depression (TRD). The presence of TRD contributes to the morbidity and excess mortality associated with MDD and has been linked ... |
36,855,289 | Can psychedelics enhance group psychotherapy A discussion on the therapeutic factors. | Despite the growth of psychedelic research, psychedelic-assisted group psychotherapy (PAGP) has received little attention in comparison to individual psychedelic-assisted psychotherapy models. In this article, we aim to discuss the therapeutic potential of PAGP, as well as outline existing models and the challenges of ... |
36,853,332 | Off-target activity of NBOMes and NBOMe analogs at the µ opioid receptor. | New psychoactive substances (NPS) are introduced on the illicit drug market at a rapid pace. Their molecular targets are often inadequately elucidated, which contributes to the delayed characterization of their pharmacological effects. Inspired by earlier findings, this study set out to investigate the µ opioid recepto... |
36,851,023 | Hofmann vs. Paracelsus Do Psychedelics Defy the Basics of Toxicology-A Systematic Review of the Main Ergolamines, Simple Tryptamines, and Phenylethylamines. | Psychedelics are experiencing a strong renaissance and will soon be incorporated into clinical practice. However, there is uncertainty about how much harm they can cause at what doses. This review aimed to collect information on the health-hazardous doses of psychedelic substances, to be aware of the risks to which pat... |
36,846,226 | Cannabis-assisted psychotherapy for complex dissociative posttraumatic stress disorder A case report. | A dissociative subtype of posttraumatic stress disorder, known as D-PTSD, has been included in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. In addition to meeting criteria for PTSD, patients endorse prominent dissociative symptoms, namely depersonalization and derealization, or detachment f... |
36,846,225 | Therapeutic effect of psilocybin in addiction A systematic review. | Psychedelic-assisted therapy e.g., with lysergic acid diethylamide (LSD) has shown promising results as treatment for substance use disorders (SUDs). Previous systematic reviews assessing the efficacy of psilocybin in SUDs only included clinical trials conducted in the last 25 years, but they may have missed clinical t... |
36,846,223 | Navigating intensive altered states of consciousness How can the set and setting key parameters promote the science of human birth | The subjective childbirth experience is crucial from a public health standpoint. There is a correlation between a negative childbirth experience and a poor mental state after birth, with effects that go far beyond the postpartum (PP) period. This paper offers a new approach as to how birthing experiences, and birth in ... |
36,845,991 | Development of a computerized adaptive substance use disorder scale for screening, measurement and diagnosis - The CAT-SUD-E. | The Computerized Adaptive Test for Substance Use Disorder (CAT-SUD), an adaptive test based on multidimensional item response theory, has been expanded to include 7 specific Diagnostic and Statistical Manual, 5th edition (DSM-5) defined SUDs. Initial testing of the new measure, the CAT-SUD expanded (CAT-SUD-E) is repor... |
36,845,985 | Interest in receiving psychedelic-assisted therapy among marginalized women Implications and findings from a community-based study in Canada. | Psychedelic-assisted therapies are receiving mounting attention for their therapeutic potential. However, little is known about interest among women who experience elevated risk of mental health and substance use disorders. This study examined interest in receiving psychedelic-assisted therapy and socio-structural fact... |
36,844,032 | Serotonergic psychedelics for depression What do we know about neurobiological mechanisms of action | Current treatment options for major depressive disorder (MDD) have limited efficacy and are associated with adverse effects. Recent studies investigating the antidepressant effect of serotonergic psychedelics-also known as classic psychedelics-have promising preliminary results with large effect sizes. In this context,... |
36,844,020 | Ethical principles of traditional Indigenous medicine to guide western psychedelic research and practice. | The resurgence of Western psychedelic research and practice has led to increasing concerns from many Indigenous Nations regarding cultural appropriation, lack of recognition of the sacred cultural positioning of these medicines, exclusionary practices in research and praxis, and patenting of traditional medicines. Indi... |
36,840,014 | Prenatal Exposure to Δ9-Tetrahydrocannabinol Affects Hippocampus-Related Cognitive Functions in the Adolescent Rat Offspring Focus on Specific Markers of Neuroplasticity. | Previous evidence suggests that prenatal exposure to THC (pTHC) derails the neurodevelopmental trajectories towards a vulnerable phenotype for impaired emotional regulation and limbic memory. Here we aimed to investigate pTHC effect on hippocampus-related cognitive functions and markers of neuroplasticity in adolescent... |
36,835,313 | The Effects of Peripubertal THC Exposure in Neurodevelopmental Rat Models of Psychopathology. | Adolescent exposure to cannabinoids as a postnatal environmental insult may increase the risk of psychosis in subjects exposed to perinatal insult, as suggested by the two-hit hypothesis of schizophrenia. Here, we hypothesized that peripubertal Δ |
36,835,247 | Characterization of the Antitumor Potential of Extracts of | Cannabis has been used for decades as a palliative therapy in the treatment of cancer. This is because of its beneficial effects on the pain and nausea that patients can experience as a result of chemoradiotherapy. Tetrahydrocannabinol and cannabidiol are the main compounds present in |
36,835,133 | Aromatic Bromination Abolishes Deficits in Visuospatial Learning Induced by MDMA (Ecstasy) in Rats While Preserving the Ability to Increase LTP in the Prefrontal Cortex. | It has recently been demonstrated that aromatic bromination at C(2) abolishes all typical psychomotor, and some key prosocial effects of the entactogen MDMA in rats. Nevertheless, the influence of aromatic bromination on MDMA-like effects on higher cognitive functions remains unexplored. In the present work, the effect... |
36,834,053 | Clinical Epigenomic Explanation of the Epidemiology of Cannabinoid Genotoxicity Manifesting as Transgenerational Teratogenesis, Cancerogenesis and Aging Acceleration. | As global interest in the therapeutic potential of cannabis and its derivatives for the management of selected diseases increases, it is increasingly imperative that the toxic profile of cannabinoids be thoroughly understood in order to correctly assess the balance between the therapeutic risks and benefits. Modern stu... |
36,830,997 | Indole Alkaloids from Psychoactive Mushrooms Chemical and Pharmacological Potential as Psychotherapeutic Agents. | Neuropsychiatric diseases such as depression, anxiety, and post-traumatic stress represent a substantial long-term challenge for the global health systems because of their rising prevalence, uncertain neuropathology, and lack of effective pharmacological treatments. The approved existing studies constitute a piece of s... |
36,827,494 | Typology of Users of Psychedelics and Alike Psychoactive Substances in Czechia Results of the National Online Survey. | The aim of this study was to define the typical groups of users of psychedelics and alike psychoactive substances in Czechia regarding various variables such as demographics, their patterns of use, or motivation for use. Data from 890 Czech respondents were collected through an online questionnaire as a part of The Nat... |
36,827,450 | Contextual determinants of mass drug administration performance Modelling fourteen years of lymphatic filariasis treatments in West Africa. | Effective mass drug administration (MDA) is the cornerstone in the elimination of lymphatic filariasis (LF) and a critical component in combatting all neglected tropical diseases for which preventative chemotherapy is recommended (PC-NTDs). Despite its importance, MDA coverage, however defined, is rarely investigated s... |
36,823,609 | Sperm capacitation and transcripts levels are altered by in vitro THC exposure. | Delta-9-tetrahydrocannabinol (THC) is the primary phytocannabinoid responsible for the psychoactive properties of cannabis and is known to interact with the endocannabinoid system, which is functionally present in the male reproductive system. Since cannabis consumption is the highest among reproductive aged males, the... |
36,820,725 | Prevalence of psychoactive substance use by adolescents in public schools in a municipality in the São Paulo Metropolitan Area, Brazil. | This study aimed to estimate the prevalence of psychoactive substance use by adolescents from public schools. This is a cross-sectional study that used a random sample of adolescents from five public schools located in a municipality in the central-west region of the São Paulo Metropolitan Area, Brazil. Information on ... |
36,815,350 | Psilocybin services in Oregon a call for awareness among clinical toxicologists. | In 2023, Oregon enacted laws regulating the manufacture and use of psilocybin products in licensed facilities for supervised sessions with trained facilitators. This commentary summarizes the final rules for psilocybin services in Oregon, and provides perspectives from a clinical toxicologist on some of the issues that... |
36,808,500 | Correlates of substance use in a large naturalistic cohort of young people with early and emerging psychosis. | Substance use remains a barrier to recovery for young people accessing early intervention services for psychosis. While correlates of use have been explored in populations experiencing a first episode of psychosis (FEP), sample sizes have been small and less research assesses cohorts at ultrahigh risk of psychosis (UHR... |
36,807,609 | Acute psilocybin enhances cognitive flexibility in rats. | Psilocybin has been shown to improve symptoms of depression and anxiety when combined with psychotherapy or other clinician-guided interventions. To understand the neural basis for this pattern of clinical efficacy, experimental and conceptual approaches that are different than traditional laboratory models of anxiety ... |
36,805,815 | An ecological momentary assessment study to examine covariates and effects of concurrent and simultaneous use of electronic cigarettes and marijuana among college students. | The prevalence of concurrent and simultaneous use of e-cigarette and marijuana among college students is high. Yet, the literature was mainly based on cross-sectional surveys with emphasis on the smoking route. This is the first ecological momentary assessment (EMA) study that examined the vaping route of nicotine-mari... |
36,801,502 | An overview of New Psychoactive Substances (NPS) in northeast Brazil NMR-based identification and analysis of ecstasy tablets by GC-MS. | The actual illicit market for synthetic drugs is characterized by a wide variety of psychoactive substances of different chemical and pharmacological classes, such as amphetamine-type stimulants and new psychoactive substances. The knowledge about its chemical composition, as well as the nature and quantity of the acti... |
36,799,677 | Polysubstance Use Patterns Associated With HIV Disease Severity Among Those With Substance Use Disorders A Latent Class Analysis. | Polysubstance use is common among people with HIV infection (PWH) and with substance use disorder (SUD), but its effects are understudied. We aimed to identify polysubstance use patterns over time and assess their associations with HIV disease severity. In 233 PWH with current or past SUD, latent class analysis identif... |
36,799,674 | Attitudes Toward Cannabis Use Legalization and Openness to Legal Use Among Young Partygoers in Norway. | The purpose of this study was to examine attitudes toward legalization of cannabis use and openness to legal use among Norwegian partygoers. We examined a combined sample ( Although 46.1% of participants reported having used cannabis at least once, only 13 (32.6%) favored legalization and 14 (25.6%) stated they would t... |
36,798,604 | Psychotherapeutic and neurobiological processes associated with ayahuasca A proposed model and implications for therapeutic use. | Ayahuasca is a psychoactive Amazonian plant brew. It is usually made from the |
36,795,823 | Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors. | Decreased dendritic spine density in the cortex is a hallmark of several neuropsychiatric diseases, and the ability to promote cortical neuron growth has been hypothesized to underlie the rapid and sustained therapeutic effects of psychedelics. Activation of 5-hydroxytryptamine (serotonin) 2A receptors (5-HT2ARs) is es... |
36,795,807 | Possible psychedelic therapeutic mechanism. | Psychedelics act on intracellular serotonin receptors that are not accessible by serotonin alone. |
36,795,782 | Alleviation of Cocaine Withdrawal and Pertinent Interactions between Salvinorin-Based Antagonists and Kappa Opioid Receptor. | The kappa opioid receptor (KOR) is involved in the regulation of both the reward and mood processes. Recent reports find that the use of drugs of abuse increases the production of dynorphin and the overall activation of KOR. Long-acting KOR antagonists, such as norbinaltorphimine (nor-BNI), JDTic, and 5-guanidinonaltri... |
36,793,424 | Psychedelic-Assisted Neuroplasticity for the Treatment of Mental Health Disorders. | The renaissance of research into psychedelics class of drugs has renewed interest for a possible psychedelic clinical therapy for treating psychiatric conditions such as treatment-resistant depression, major depressive-disorder, post-traumatic stress disorder, and other neuropsychiatric diseases. Psychedelics are known... |
36,786,290 | Neural Mechanisms and Psychology of Psychedelic Ego Dissolution. | Neuroimaging studies of psychedelics have advanced our understanding of hierarchical brain organization and the mechanisms underlying their subjective and therapeutic effects. The primary mechanism of action of classic psychedelics is binding to serotonergic 5-HT2A receptors. Agonist activity at these receptors leads t... |
36,782,291 | Lower-risk substance use guidelines accessible by youth. | Lower-risk substance use guidelines (LRSUGs) are an evidence-based harm reduction strategy used to provide information to people who use drugs so they can reduce harms associated with substance use. This study aimed to identify LRSUGs accessible to youth and to characterize the recommendations within these guidelines. ... |
36,781,142 | Unblinding and demand characteristics in the treatment of depression. | Blinding of treatment allocation in clinical trials in psychiatry is regarded as an ideal. The potential impact of unblinding chimes with a general concern for psychological research so-called demand characteristics can undermine confidence in findings from experimental and clinical studies. Scepticism can result in ni... |
36,781,093 | Handling prevents and reverses cognitive deficits induced by sub-chronic phencyclidine in a model for schizophrenia in rats. | Treatments for schizophrenia are not effective in ameliorating cognitive deficits. Therefore, novel therapies are needed to treat cognitive impairments associated with schizophrenia (CIAS), which are modelled in rats through administration of sub-chronic phencyclidine (scPCP). We have previously shown that enrichment v... |
36,780,161 | Assessment of Orally Administered Δ9-Tetrahydrocannabinol When Coadministered With Cannabidiol on Δ9-Tetrahydrocannabinol Pharmacokinetics and Pharmacodynamics in Healthy Adults A Randomized Clinical Trial. | Controlled clinical laboratory studies have shown that cannabidiol (CBD) can sometimes attenuate or exacerbate the effects of Δ9-tetrahydrocannabinol (Δ9-THC). No studies have evaluated differences in pharmacokinetics (PK) of Δ9-THC and pharmacodynamics (PD) between orally administered cannabis extracts that vary with ... |
36,779,819 | The prescription of psychedelic therapies in Australia and New Zealand A brief survey of psychiatrists. | To explore the knowledge and attitudes of psychiatrists about psychedelics therapies. Access to a cross-sectional survey was distributed to psychiatrists through social media channels. Attitudes and knowledge about psychedelic therapies were recorded using Likert scales and ranking questions. Fifty-eight complete respo... |
36,774,807 | Crash-involved THC-positive drivers in Norway have a high frequency of polysubstance use. | Tetrahydrocannabinol (THC) is the most frequently detected drug in blood samples from apprehended drug driving suspects in Norway. This investigation aimed to study the extent of polysubstance use among apprehended crash-involved drivers with THC concentrations above the legal limit and explore the importance of THC in... |
36,774,449 | Examining associations between MDMAecstasy and classic psychedelic use and impairments in social functioning in a U.S. adult sample. | Impairment in social functioning is a common source of morbidity across many mental health disorders, yet there is a dearth of effective and easily implemented interventions to support social functioning. MDMAecstasy and classic psychedelics (psilocybin, LSD, peyote, mescaline) represent two potential treatments for im... |
36,772,834 | A scoping review of spirituality in relation to substance use disorders Psychological, biological, and cultural issues. | Spirituality is a construct encompassing a diversity of strongly held beliefs and pursuits related to lifes meaning and purpose. Empirical studies in key domains of spirituality related to substance use disorder (SUD) can be valuable in guiding research, and potentially clinical care. To conduct a scoping review of res... |
36,771,119 | Toxicity of the 3,4-Methylenedioxymethamphetamine and Its Enantiomers to | MDMA (3,4-methylenedioxymethamphetamine) is a chiral psychoactive recreational drug sold in illicit markets as racemate. Studies on the impact of MDMA on aquatic organisms are scarce. While enantioselectivity in toxicity in animals and humans has been reported, none is reported on aquatic organisms. This study aimed to... |
36,770,970 | A Colorimetric Method for the Rapid Estimation of the Total Cannabinoid Content in Cannabis Samples. | A colorimetric method for the estimation of the total content of cannabinoids in cannabis samples is proposed. The assay is based on the reaction of these compounds with the reagent Fast Blue B (FBB), which has been immobilized into polydimethylsiloxane (PDMS). The reaction and detection conditions have been establishe... |
36,770,831 | Chiral Separation of Cannabichromene, Cannabicyclol, and Their Acidic Analogs on Polysaccharide Chiral Stationary Phases. | Until recently, chirality has not been a major focus in the study of cannabinoids, as most cannabinoids of interest, such as cannabidiol and tetrahydrocannabinol, exist as a single isomer from natural sources. However, this is changing as more cannabinoids are identified, and compounds such as cannabichromene and canna... |
36,768,835 | Cannabinoids in the Modulation of Oxidative Signaling. | Cannabis sativa-derived compounds, such as delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), and components of the endocannabinoids system, such as N-arachidonoylethanolamide (anandamide, AEA) and 2-arachidonoylglycerol (2-AG), are extensively studied to investigate their numerous biological effects, including ... |
36,767,678 | Analysis of Cannabinoids in Biological Specimens An Update. | Cannabinoids are still the most consumed drugs of abuse worldwide. Despite being considered less harmful to human health, particularly if compared with opiates or cocaine, cannabis consumption has important medico-legal and public health consequences. For this reason, the development and optimization of sensitive analy... |
36,767,188 | Substance Use and Attendance Motives of Electronic Dance Music (EDM) Event Attendees A Survey Study. | EDM event attendees are a high-risk population for substance use and associated adverse effects. The aim of this study was to examine substance use at EDM events, focusing on associations between attendance motives and substance use. Sociodemographic characteristics, event specifics, past-year use, and attendance motiv... |
36,764,162 | A novel ego dissolution scale A construct validation study. | Ego dissolution (i.e., ego loss, ego disintegration, ego death, or self-loss) is a conscious state marked by a loss or diminution of ones sense of self and a lack of first-person experience. We developed a novel, valid, and internally consistent ego dissolution scale to both (a) assess trait-like aspects of ego dissolu... |
36,764,087 | The impact of recreational cannabis markets on motor vehicle accident, suicide, and opioid overdose fatalities. | In the U.S., an increasing number of states are legalizing regulated commercial markets for recreational cannabis, which allows private industry to produce, distribute, and sell marijuana to those 21 and older. The health impacts of these markets are not fully understood. Preliminary evidence suggests recreational mark... |
36,762,714 | N,N-dimethyltryptamine affects electroencephalography response in a concentration-dependent manner-A pharmacokineticpharmacodynamic analysis. | N,N-dimethyltryptamine (DMT) is a psychedelic substance and is being used as a research tool in investigations of the neurobiology behind the human consciousness using different brain imaging techniques. The effects of psychedelics have commonly been studied using electroencephalography (EEG) and have been shown to pro... |
36,762,110 | Binding and functional structure-activity similarities of 4-substituted 2,5-dimethoxyphenyl isopropylamine analogues at 5-HT | Certain 4-substituted analogs of 1-(2,5-dimethoxyphenyl)isopropylamine (2,5-DMA) are psychoactive classical hallucinogens or serotonergic psychedelic agents that function as human 5-HT |
36,758,771 | Preparation of hyaluronic acid-loaded Harmine polymeric micelles and in vitro effect anti-breast cancer. | To prepare hyaluronic acid-loaded Harmine polymeric micelles with CD The carboxyl group on hyaluronic acid is coupled to the amino group on 3,5-bis(trifluoromethyl)benzylamine by an amidation reaction. And the polymeric micelles self-assemble to encapsulate the Harmine in a hydrophobic core, characterized the polymer m... |
36,756,911 | Ketamine detection in urine samples from patients poisoned by recreational drugs epidemiologic, clinical, and toxicologic profiles. | To describe the epidemiologic, clinical, and toxicologic profiles of patients who used recreational ketamine and experienced acute poisoning. Retrospective observational study of patients attended by several emergency medical services in the Balearic Islands for analytically confirmed acute poisoning after using ketami... |
36,753,839 | Concentrations of LSD, 2-oxo-3-hydroxy-LSD, and iso-LSD in hair segments of 18 drug abusers. | Lysergic acid diethylamide (LSD) is one of the most widely abused hallucinogens, which can alter consciousness, produce mental disorder, and cause harmful behavior. 1-Propionyl-LSD (1 P-LSD), a novel derivative of LSD, has the similar hallucinogenic effect. It is a control substance in several countries. 1 P-LSD can ac... |
36,753,805 | Effects of Δ⁹-tetrahydrocannabinol (THC), cannabidiol (CBD), and THCCBD mixtures on fentanyl versus food choice in rhesus monkeys. | There is considerable interest in utilizing cannabis-based products as adjuvants to opioid agonist therapies as phytocannabinoids like Δ This study examined the effects of THC and cannabidiol (CBD), the two most prominent compounds in cannabis, on the reinforcing effects of fentanyl in rhesus monkeys in a food versus d... |
36,753,675 | A survey of Australian psychiatrists and psychiatry trainees knowledge of and attitudes towards psychedelics in the treatment of psychiatric disorders. | To assess Australian psychiatrists and psychiatry trainees knowledge of and attitudes towards psychedelics as treatment for psychiatric disorders. Australian members of the Royal Australian and New Zealand College of Psychiatrists were invited to participate in an anonymous survey that ran from October 1 to November 30... |
36,753,397 | Developmental Neurotoxicity Screen of Psychedelics and Other Drugs of Abuse in Larval Zebrafish ( | In recent years, psychedelics have garnered significant interest as therapeutic agents for treating diverse neuropsychiatric disorders. However, the potential for these compounds to produce developmental neurotoxicity has not been rigorously assessed, and much of the available safety data is based on epidemiological st... |
36,753,370 | Microbiota-derived psychedelics Lessons from COVID-19. | Emil Kraepelin believed that dementia praecox, the disorder we now call schizophrenia, was caused by the brain being poisoned with toxins generated in other parts of the body, especially the mouth, intestine or genitals. In this regard, Kraepelin hinted at the microbiome and conceptualized microbial molecules as driver... |
36,753,025 | Recent Progress in Mind-Body Therapies in Cancer Care. | Mind-body therapies (MBTs) are integrative medicine modalities that continue to grow in popularity among people with cancer. MBTs are used to enhance well-being and most commonly include relaxation and imagery, hypnosis, yoga, meditation, Tai Chi and Qigong, and creative therapies. Biofield and psychedelic-assisted the... |
36,752,668 | Intoxications with synthetic cannabinoids. | Synthetic Cannabinoid Receptor Agonists (SCRAs) are a group of New Psychoactive Substances. They are used recreationally to mimic the effects of THC in cannabis. However, THC is a partial agonist of the CB1-receptor and SCRAs are full agonists. Because of this specificity and potency serious adverse events may occur am... |
36,752,335 | Effects of Ketanserin, M100907 and Olanzapine on hallucinogenic like action induced by 2,5-dimethoxy-4-methylamphetamine. | 2,5-dimethoxy-4-methylamphetamine (DOM) is a kind of hallucinogen of phenylalkylamine. Psychedelic effects mainly include audiovisual synesthesia, complex imagery, disembodiment etc. that can impair control and cognition leading to adverse consequences such as suicide. By now, there are no specific drugs regarding the ... |
36,750,905 | Behavioral, biochemical and histopathological toxic profiles induced by sub-chronic cannabimimetic WIN55, 212-2 administration in mice. | WIN55, 212-2 mesylate is a synthetic cannabinoid (SC) agonist of CB1 and CB2 receptors with much higher affinity to CB1 receptor than tetrahydrocannabinol and many potential therapeutic effects. Few studies have evaluated SCs effects on more complex animal behavior and sex differences in cannabinoids toxicology. The cu... |
36,743,241 | What good are psychedelic humanities | The revival of psychedelic research has been dominated by the biomedical sciences. Yet it raises questions that cannot be answered by laboratory experiments and clinical trials alone. Among these are questions pertaining to the conceptual and practical frameworks that render experimental and clinical findings meaningfu... |
36,741,125 | Classic psychedelics do not affect T cell and monocyte immune responses. | Classic psychedelics have been shown to exert therapeutic potential for the treatment of various psychiatric disorders, neuropsychiatric diseases, and neuronal damage. Besides their psychopharmacological activity, psychedelics have been reported to modulate immune functions. There has thus far been a sparse exploration... |
36,740,601 | Association between cannabis use and blood pressure levels according to comorbidities and socioeconomic status. | The associations between blood pressure and cannabis use remain inconsistent. The purpose of our study was to examine gender stratified associations of cannabis use and blood pressure systolic, diastolic blood pressure (BP), pulse pressure (PP) levels among the general UK Biobank population based study. Among 91,161 vo... |
36,740,518 | A complex systems perspective on psychedelic brain action. | Recent findings suggesting the potential transdiagnostic efficacy of psychedelic-assisted therapy have fostered the need to deepen our understanding of psychedelic brain action. Functional neuroimaging investigations have found that psychedelics reduce the functional segregation of large-scale brain networks. However, ... |
36,740,140 | Single-dose psilocybin for a treatment-resistant episode of major depression Impact on patient-reported depression severity, anxiety, function, and quality of life. | COMP360 is a proprietary, synthetic formulation of psilocybin being developed for treatment-resistant depression (TRD), a burdensome, life-threatening illness with high global impact. Here, we expand upon the previous report of primary outcomes from a phase 2 study of COMP360 in individuals with TRD-the largest randomi... |
36,740,030 | Reduced emergent character of neural dynamics in patients with a disrupted connectome. | High-level brain functions are widely believed to emerge from the orchestrated activity of multiple neural systems. However, lacking a formal definition and practical quantification of emergence for experimental data, neuroscientists have been unable to empirically test this long-standing conjecture. Here we investigat... |
36,738,015 | Effect of acrolein on the formation of harman and norharman in chemical models and roast beef patties. | Harman and norharman were the most abundant β-carboline-type heterocyclic amines (HCAs) detected in various foodstuffs. Unsaturated fatty acids in foods may undergo rapid oxidative deterioration during transportation, storage and heat treatment, forming reactive carbonyl species (RCS). This work studied the effects of ... |
36,736,229 | Adult use of highly-potent Δ9-THC cannabis concentrate products by U.S. state cannabis legalization status, 2021. | Compared to plantflower cannabis products, cannabis concentrates have higher average potency of delta-9-tetrahydrocannabinol (Δ9-THC), which may be associated with greater likelihood of cannabis-related harms. Information on factors associated with use of cannabis concentrates is needed. Respondents were 4,328 adult pa... |
36,735,751 | LSD-induced increase of Ising temperature and algorithmic complexity of brain dynamics. | A topic of growing interest in computational neuroscience is the discovery of fundamental principles underlying global dynamics and the self-organization of the brain. In particular, the notion that the brain operates near criticality has gained considerable support, and recent work has shown that the dynamics of diffe... |
36,732,585 | Individualized fMRI connectivity defines signatures of antidepressant and placebo responses in major depression. | Though sertraline is commonly prescribed in patients with major depressive disorder (MDD), its superiority over placebo is only marginal. This is in part due to the neurobiological heterogeneity of the individuals. Characterizing individual-unique functional architecture of the brain may help better dissect the heterog... |
36,729,996 | Reduced death anxiety as a mediator of the relationship between acute subjective effects of psychedelics and improved subjective well-being. | Research over the past several decades suggests that meaningful psychedelic experiences can engender long-term effects on subjective wellbeing. However, less research has investigated the psychological mechanisms through which these effects may emerge. In the present study, participants ( |
36,729,145 | Reconsidering dissociation as a predictor of antidepressant efficacy for esketamine. | The relationship between subjective drug experience and antidepressant outcomes for ketamine derivatives is poorly understood but of high clinical relevance. Esketamine is the patented (S)-enantiomer of ketamine and has regulatory approval for psychiatric applications. We examined the relationship between acute dissoci... |
36,724,866 | The high frequency oscillation in orbitofrontal cortex is susceptible to phenethylamine psychedelic 25C-NBOMe in male rats. | Serotoninergic psychedelics induced extensive alterations in perception and cognition, which has been attributable to its disruptive effect on oscillatory rhythms of prefrontal cortex. However, there is a lack of information how serotoninergic psychedelics affect the intra-prefrontal network, which intrinsically intera... |
36,720,405 | Prevalence and associations of challenging, difficult or distressing experiences using classic psychedelics. | Previous studies have investigated challenging, difficult, or distressing classic psychedelic experiences, but little is known about the prevalence and associations of such experiences. Using nationally representative data of the US adult population (N 2822), this study examined the prevalence and associations of chall... |
36,718,782 | Quantifying the Root-to-Shoot Transfer of 4,4-Methylenedianiline Using Pressure Chamber and Intact Plant Methods. | The high-production-volume chemical 4,4-methylenedianiline (4,4-MDA) is an aromatic amine used to manufacture 4,4-methylenedianiline diisocyanate for polyurethane production. Based on 4,4-MDAs octanolwater partition coefficient (K |
36,715,317 | Towards mapping neuro-behavioral heterogeneity of psychedelic neurobiology in humans. | Precision psychiatry aims to identify markers of inter-individual variability that allow predicting the right treatment for each patient. However, bridging the gap between molecular-level manipulations and neural systems-level functional alterations remains an unsolved problem in psychiatry. After decades of low succes... |
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