pubmed_id int64 8.72M 36.9M | title stringlengths 1 580 ⌀ | abstract stringlengths 1 6.54k ⌀ |
|---|---|---|
36,561,896 | Treatment-Resistant Bipolar Depression Therapeutic Trends, Challenges and Future Directions. | Bipolar disorder (BD) is a chronic mental illness impacting 1-2% of the population worldwide and causing high rates of functional impairment. Patients with BD spend most of their time in depressive episodes and up to one-third of patients do not respond to adequate doses of medications. Although no consensus exists for... |
36,557,949 | Microwave- and Ultrasound-Assisted Extraction of Cannabinoids and Terpenes from Cannabis Using Response Surface Methodology. | Limited studies have explored different extraction techniques that improve cannabis extraction with scale-up potential. Ultrasound-assisted and microwave-assisted extraction were evaluated to maximize the yield and concentration of cannabinoids and terpenes. A central composite rotatable design was used to optimize ind... |
36,557,913 | Cold Ethanol Extraction of Cannabinoids and Terpenes from Cannabis Using Response Surface Methodology Optimization and Comparative Study. | Efficient cannabis biomass extraction can increase yield while reducing costs and minimizing waste. Cold ethanol extraction was evaluated to maximize yield and concentrations of cannabinoids and terpenes at different temperatures. Central composite rotatable design was used to optimize two independent factors sample-to... |
36,555,842 | Dysmenorrhoea Can Medicinal Cannabis Bring New Hope for a Collective Group of Women Suffering in Pain, Globally | Dysmenorrhoea effects up to 90% of women of reproductive age, with medical management options including over-the-counter analgesia or hormonal contraception. There has been a recent surge in medicinal cannabis research and its analgesic properties. This paper aims to critically investigate the current research of medic... |
36,555,217 | Arylcyclohexylamine Derivatives Pharmacokinetic, Pharmacodynamic, Clinical and Forensic Aspects. | Since the 2000s, an increasing number of new psychoactive substances (NPS) have appeared on the drug market. Arylcyclohexylamine (ACH) compounds such as ketamine, phencyclidine and eticyclidine derivatives are of particular concern, given their rapidly increasing use and the absence of detailed toxicity data. First use... |
36,555,111 | Cannabidiol and Beta-Caryophyllene in Combination A Therapeutic Functional Interaction. | Cannabis contains over 500 distinct compounds, which include cannabinoids, terpenoids, and flavonoids. However, very few of these compounds have been studied for their beneficial effects. There is an emerging concept that the constituents of the cannabis plant may work in concert to achieve better therapeutic benefits.... |
36,554,603 | Epigenomic and Other Evidence for Cannabis-Induced Aging Contextualized in a Synthetic Epidemiologic Overview of Cannabinoid-Related Teratogenesis and Cannabinoid-Related Carcinogenesis. | Twelve separate streams of empirical data make a strong case for cannabis-induced accelerated aging including hormonal, mitochondriopathic, cardiovascular, hepatotoxic, immunological, genotoxic, epigenotoxic, disruption of chromosomal physiology, congenital anomalies, cancers including inheritable tumorigenesis, telome... |
36,553,349 | Hopelessness, Suicidality, and Co-Occurring Substance Use among Adolescent Hallucinogen Users-A National Survey Study. | (1) Objectives Hallucinogens are being explored as a potential treatment of psychiatric disorders. Micro dosing of illicitly purchased hallucinogen drugs is on the rise despite conclusive benefits. We aimed to evaluate the prevalence and odds of hopelessness, suicidality, and co-occurring substance use among adolescent... |
36,551,296 | Efficient Synthesis for Altering Side Chain Length on Cannabinoid Molecules and Their Effects in Chemotherapy and Chemotherapeutic Induced Neuropathic Pain. | (1) Background Recently, a number of side chain length variants for tetrahydrocannabinol and cannabidiol have been identified in cannabis however, the precursor to these molecules would be based upon cannabigerol (CBG). Because CBG, and its side chain variants, are rapidly converted to other cannabinoids in the plant, ... |
36,549,374 | Effects of delta-9 tetrahydrocannabinol on fear memory labilization and reconsolidation A putative role of GluN2B-NMDA receptor within the dorsal hippocampus. | Cannabis preparations could be an effective reconsolidation-based treatment for post-traumatic stress disorder. However, the effects of Δ |
36,549,107 | An electrochemical aptasensor for Δ | We present a novel on-off, cost-effective, rapid electrochemical aptasensor combined with a microfluidics cartridge system for the detection of Δ |
36,545,240 | Subacute effects of a single dose of psilocybin on biomarkers of inflammation in healthy humans An open-label preliminary investigation. | Psilocybin is a serotonergic psychedelic that has gained prominent attention recently as a potential therapeutic for neuropsychiatric disorders including Major Depressive Disorder. Pre-clinical and initial studies in humans suggest that serotonin 2A receptor agonists, including serotonergic psychedelics, have anti-infl... |
36,545,038 | The economics of psychedelic-assisted therapies A research agenda. | After a long hiatus, psychiatry is undergoing a resurgence of interest in psychedelic drugs as therapy for a wide range of mental health disorders Accumulating clinical evidence suggests substantial potential for psychedelics used in a therapeutic context, as treatment for, among other disorders, depression, post-traum... |
36,545,037 | Moderators of ayahuascas biological antidepressant action. | The understanding of biological responses to psychedelics with antidepressant potential is imperative. Here we report how a set of acute parameters, namely emotional (depressive symptoms), cognitive (psychedelic experience), and physiological (salivary cortisol), recorded during an ayahuasca dosing session, modulated s... |
36,536,916 | Single-dose psilocybin for treatment-resistant obsessive-compulsive disorder A case report. | Classic psychedelics, such as psilocybin, act on the brains serotonin system and produce striking psychological effects. Early work in the 1950s and 1960s and more recent controlled studies suggest benefit from psychedelic treatment in a number of conditions. A few case reports in recreational users and a single experi... |
36,535,992 | Associations between MDMAecstasy, classic psychedelics, and suicidal thoughts and behaviors in a sample of U.S. adolescents. | Suicide is one of the leading causes of death amongst adolescents and decades of research have failed to curb suicide rates within this population. There is thus a need to better understand factors that correlate with adolescent suicidal thoughts and behaviors (STBs). MDMAecstasy and classic psychedelics represent two ... |
36,535,547 | Psychotherapists openness to engage their patients in Psilocybin-Assisted Therapy for mental health treatment. | Despite psychedelic research initially ceasing in the 1970-80s, the findings documented encouraged researchers to re-examine the safety and efficacy of treating mental health with psychedelics. Of particular focus, psilocybin has shown to have therapeutic potential for a variety of mental health problems and was grante... |
36,534,415 | Meditation trips A thematic analysis of the combined naturalistic use of psychedelics with meditation practices. | Similarities between meditative and psychedelic states have long been recognized. Recently, parallels in the psychological mechanisms mediating the beneficial effects of mindfulness and psychedelic treatments-as well as their potential therapeutic complementarity-have been noted. However, empirical research in this are... |
36,534,233 | Research into Psychedelic-Assisted Psychotherapy for Anorexia Nervosa Should be Funded. | Eating disorders are debilitating diseases that have twin impacts on the body and mind and are associated with a number of physiological and psychological comorbidities (Blinder, Cumella, and Sanathara 2006 Casiero and Frishman 2006), including increased suicide risk (Arcelus et al. 2011 Lipson and Sonneville 2020). In... |
36,532,196 | Lower-dose psycholytic therapy - A neglected approach. | Lysergic acid diethylamide (LSD) and similar psychoactive drugs have been used in psychotherapy since 1949, when the first clinical study with lower-dose LSD showed therapeutically relevant effects. This caused an intense interest among psychotherapists and researchers, alike, on an international scale. In 1960, the us... |
36,532,184 | Therapeutic use of psilocybin Practical considerations for dosing and administration. | The interest in psilocybin as a therapeutic approach has grown exponentially in recent years. Despite increasing access, there remains a lack of practical guidance on the topic for health care professionals. This is particularly concerning given the medical complexity and vulnerable nature of patients for whom psilocyb... |
36,529,299 | Effect of psilocybin on decision-making and motivation in the healthy rat. | Psilocybin and its active metabolite psilocin are hallucinogenic serotonergic agonists with high affinity for several serotonin receptors. In addition to underlying the hallucinogenic effects of these compounds, serotonin receptor activation also has important effects on decision-making and goal-directed behaviors. The... |
36,529,297 | Effects of prenatal exposure to THC on hippocampal neural development in offspring. | Cannabis use is a worldwide issue with the development of legalization. Prenatal exposure to Δ9-tetrahydrocannabinol (THC), the main psychoactive component of cannabis, is related to affect fetal nervous system development. In our present study, we administered THC to pregnant mice from gestational day 5.5-12.5. Differ... |
36,529,260 | Experimental strategies to discover and develop the next generation of psychedelics and entactogens as medicines. | Research on classical psychedelics (psilocybin, LSD and DMT) and entactogen, MDMA, has produced a renaissance in the search for more effective drugs to treat psychiatric, neurological and various peripheral disorders. Psychedelics and entactogens act though interaction with 5-HT |
36,527,808 | Determination of urinary metabolites of cannabidiol, Δ | In this study, an automated online micro-solid-phase extraction (μSPE)-liquid chromatography-tandem mass spectrometry (LC-MSMS) method was developed and validated for the detection of metabolites of cannabidiol (CBD), Δ |
36,527,355 | A unified model of ketamines dissociative and psychedelic properties. | Ketamine is an N-methyl-d-aspartate antagonist which is increasingly being researched and used as a treatment for depression. In low doses, it can cause a transitory modification in consciousness which was classically labelled as dissociation. However, ketamine is also commonly classified as an atypical psychedelic and... |
36,525,422 | Application of machine learning and complex network measures to an EEG dataset from ayahuasca experiments. | Ayahuasca is a blend of Amazonian plants that has been used for traditional medicine by the inhabitants of this region for hundreds of years. Furthermore, this plant has been demonstrated to be a viable therapy for a variety of neurological and mental diseases. EEG experiments have found specific brain regions that cha... |
36,525,274 | Association of a Positive Drug Screening for Cannabis With Mortality and Hospital Visits Among Veterans Affairs Enrollees Prescribed Opioids. | Cannabis has been proposed as a therapeutic with potential opioid-sparing properties in chronic pain, and its use could theoretically be associated with decreased amounts of opioids used and decreased risk of mortality among individuals prescribed opioids. To examine the risks associated with cannabis use among adults ... |
36,525,085 | Multinational Association of Supportive Care in Cancer (MASCC) expert opinionconsensus guidance on the use of cannabinoids for gastrointestinal symptoms in patients with cancer. | Gastrointestinal symptoms are common in patients with cancer, whether related to treatment or a direct effect of the disease itself. Patients may choose to access cannabinoids outside of their formal medical prescriptions to palliate such symptoms. However, clinical guidelines are lacking in relation to the use of such... |
36,523,876 | Reactivations after 5-methoxy-N,N-dimethyltryptamine use in naturalistic settings An initial exploratory analysis of the phenomenons predictors and its emotional valence. | The psychedelic 5-MeO-DMT has shown clinical potential due to its short duration and ability to induce mystical experiences. However, a phenomenon known as reactivations (similar to flashbacks) is a poorly understood and frequently reported phenomenon which appears associated with 5-MeO-DMT use and warranted further in... |
36,521,179 | Pharmacological Mechanism of the Non-hallucinogenic 5-HT | Ariadne is a non-hallucinogenic analog in the phenylalkylamine chemical class of psychedelics that is closely related to an established synthetic hallucinogen, 2,5-dimethoxy-4-methyl-amphetamine (DOM), differing only by one methylene group in the α-position to the amine. Ariadne has been tested in humans including clin... |
36,517,480 | Merging enzymatic and synthetic chemistry with computational synthesis planning. | Synthesis planning programs trained on chemical reaction data can design efficient routes to new molecules of interest, but are limited in their ability to leverage rare chemical transformations. This challenge is acute for enzymatic reactions, which are valuable due to their selectivity and sustainability but are few ... |
36,517,243 | Cannabinoid CB1 Receptors Are Expressed in a Subset of Dopamine Neurons and Underlie Cannabinoid-Induced Aversion, Hypoactivity, and Anxiolytic Effects in Mice. | Cannabinoids modulate dopamine (DA) transmission and DA-related behavior, which has been thought to be mediated initially by activation of cannabinoid CB1 receptors (CB1Rs) on GABA neurons. However, there is no behavioral evidence supporting it. In contrast, here we report that CB1Rs are also expressed in a subset of D... |
36,516,137 | A sense of the bigger picture A qualitative analysis of follow-up interviews with people with bipolar disorder who self-reported psilocybin use. | People with bipolar disorder (BD) spend more time depressed than manichypomanic, and depression is associated with greater impairments in psychosocial functioning and quality of life than maniahypomania. Emerging evidence suggests psilocybin, the psychoactive compound in magic mushrooms, is a promising treatment for un... |
36,515,406 | Therapeutic uses of psychedelics for eating disorders and body dysmorphic disorder. | Clinical use of psychedelics has gained considerable attention, with promising benefits across a range of mental disorders. Current pharmacological and psychotherapeutic treatments for body dysmorphic disorder (BDD) and eating disorders (EDs) have limited efficacy. As such, other treatment options such as psychedelic-a... |
36,515,370 | Risks and benefits of psilocybin use in people with bipolar disorder An international web-based survey on experiences of magic mushroom consumption. | Psilocybin, the primary psychoactive component of psychedelic magic mushrooms, may have potential for treating depressive symptoms, and consequent applications for bipolar disorder (BD). Knowledge of the risks and benefits of psilocybin in BD is limited to case studies. To support the design of clinical trials, we surv... |
36,513,161 | Psilocybin-assisted therapy improves psycho-social-spiritual well-being in cancer patients. | While psychedelics have been shown to improve psycho-spiritual well-being, the underlying elements of this change are not well-characterized. The NIH-HEALS posits that psycho-social-spiritual change occurs through the factors of Connection, Reflection Introspection, and Trust Acceptance. This study aimed to evaluate th... |
36,512,813 | Psychedelic-Assisted Therapy and Psychedelic Science A Review and Perspective on Opportunities in Neurosurgery and Neuro-Oncology. | After a decades-long pause, psychedelics are again being intensely investigated for treating a wide range of neuropsychiatric ailments including depression, anxiety, addiction, post-traumatic stress disorder, anorexia, and chronic pain syndromes. The classic serotonergic psychedelics psilocybin and lysergic acid diethy... |
36,510,483 | Receptor-mediated effects of Δ | Δ |
36,508,935 | Cannabis use in Attention - DeficitHyperactivity Disorder (ADHD) A scoping review. | Treatments for Adult ADHD include stimulants, two non-stimulant medications, as well as cognitive-behavioral therapy (CBT). These pharmacological agents are often associated with side effects, contributing to poor treatment adherence. Patients with ADHD have regularly stated that cannabis has helped improve their ADHD ... |
36,508,401 | The C4EB study-Transvamix (10% THC 5% CBD) to treat chronic pain in epidermolysis bullosa A protocol for an explorative randomized, placebo controlled, and double blind intervention crossover study. | Patients with the genetic blistering skin condition epidermolysis bullosa (EB) report severe pain as a consequence of skin and mucous membrane lesions including blisters, wounds, and scars. Adequate symptom alleviation is not often achieved using conventional pharmacologic interventions. Finding novel approaches to pai... |
36,507,308 | Integrated world modeling theory expanded Implications for the future of consciousness. | Integrated world modeling theory (IWMT) is a synthetic theory of consciousness that uses the free energy principle and active inference (FEP-AI) framework to combine insights from integrated information theory (IIT) and global neuronal workspace theory (GNWT). Here, I first review philosophical principles and neural sy... |
36,506,427 | Holding on or letting go Patient experiences of control, context, and care in oral esketamine treatment for treatment-resistant depression A qualitative study. | Ketamine and its enantiomer esketamine represent promising new treatments for treatment-resistant depression (TRD). Esketamine induces acute, transient psychoactive effects. How patients perceive esketamine treatment, and which conditions facilitate optimal outcomes, remains poorly understood. Understanding patient per... |
36,503,404 | Assessment of clinical outcomes in patients with post-traumatic stress disorder analysis from the UK Medical Cannabis Registry. | The current paucity of clinical evidence limits the use of cannabis-based medicinal products (CBMPs) in post-traumatic stress disorder (PTSD). This study investigates health-related quality of life (HRQoL) changes and adverse events in patients prescribed CBMPs for PTSD. A case-series of patients from the UK Medical Ca... |
36,503,051 | Maternal behaviours and adult offspring behavioural deficits are predicted by maternal TNFα concentration in a rat model of neurodevelopmental disorders. | Exposure to inflammatory stressors during fetal development is a major risk factor for neurodevelopmental disorders (NDDs) in adult offspring. Maternal immune activation (MIA), induced by infection, causes an acute increase in pro-inflammatory cytokines which can increase the risk for NDDs directly by inducing placenta... |
36,501,395 | Rumors of Psychedelics, Psychotropics and Related Derivatives in | There are almost 1000 species of |
36,500,694 | Development and Validation of the LC-MSMS Method for Determination of 130 Natural and Synthetic Cannabinoids in Cannabis Oil. | Dietary supplements are widely available products used by millions of people around the world. Unfortunately, the procedure of adding pharmaceutical and psychoactive substances has recently been observed, in order to increase the effectiveness of supplements in the form of hemp oils. For this reason, it is extremely im... |
36,499,610 | Psychedelic-Induced Serotonin 2A Receptor Downregulation Does Not Predict Swim Stress Coping in Mice. | Serotoninergic psychedelics such as psilocybin have been reported to elicit a long-lasting reduction in depressive symptoms. Although the main target for serotoninergic psychedelics, serotonin type 2A receptor (5-HT |
36,498,868 | Genetic Variants Associated with Long-Terminal Repeats Can Diagnostically Classify | null |
36,494,088 | Social genetic effects for drug use disorder among spouses. | Preclinical and human studies suggest that a social partners genotype may be associated with addiction-related outcomes. This study measured whether spousal genetic makeup is associated with risk of developing drug use disorder (DUD) during marriage and whether the risk associated with a spouses genotype could be disen... |
36,484,577 | Egocentric Network Characteristics and Cannabis Use in a Sample of Young Adult Medical Cannabis Patients and Nonpatient Users. | Social factors play an important role in young adults substance use behaviors, but little is known about how egocentric social network factors are related to young adults cannabis use. Young adults also report medicinal and recreational uses of cannabis, which may alter the strength of these relationships. Therefore, m... |
36,481,259 | Nasal accumulation and metabolism of Δ | Passive aerosol exposure to Δ |
36,481,228 | Patients recovery and non-recovery narratives after intravenous ketamine for treatment-resistant depression. | Intravenous (IV) ketamine is an effective therapy for treatment-resistant depression. A large data base is confirmatory and steadily expanding. Qualitative studies can inform best practices and suggest new research directions. As part of a clinical trial designed to identify biomarkers of ketamine response, a qualitati... |
36,480,624 | The therapeutic potential of psychedelics. | The development of psychedelics as medicines faces several challenges. |
36,477,925 | Use of the head-twitch response to investigate the structure-activity relationships of 4-thio-substituted 2,5-dimethoxyphenylalkylamines. | 4-Thio-substituted phenylalkylamines such as 2,5-dimethoxy-4-ethylthiophenethylamine (2C-T-2) and 2,5-dimethoxy-4-n-propylthiophenethylamine (2C-T-7) produce psychedelic effects in humans and have been distributed as recreational drugs. The present studies were conducted to examine the structure-activity relationships ... |
36,477,830 | Psychedelic Drug Legislative Reform and Legalization in the US. | Psychedelic drugs are becoming accessible in the US through a patchwork of state legislative reforms. This shift necessitates consensus on treatment models, education and guidance for health care professionals, and planning for implementation and regulation. To assess trends in psychedelics legislative reform and legal... |
36,476,619 | Funnel metadynamics and behavioral studies reveal complex effect of D2AAK1 ligand on anxiety-like processes. | Anxiety is a troublesome symptom for many patients, especially those suffering from schizophrenia. Its regulation involves serotonin receptors, targeted e.g. by antipsychotics or psychedelics such as LSD. 5-HT |
36,476,377 | Rapid antidepressant-like effect of non-hallucinogenic psychedelic analog lisuride, but not hallucinogenic psychedelic DOI, in lipopolysaccharide-treated mice. | Classical psychedelics with 5-hydroxytryptamine-2A receptor (5-HT |
36,476,352 | Effects of ketamine optical isomers, fluoxetine and naloxone on timing in differential reinforcement of low-rate response (DRL) 72-s task in rats. | (S)-ketamine-induced rapid-acting antidepressant effects have revolutionized the pharmacotherapy of major depression however, this medication also produces psychotomimetic effects such as timing distortion. While (R)-ketamine produces fewer dissociative effects, its antidepressant actions are less studied. Depression i... |
36,476,177 | Oxygen and the Spark of Human Brain Evolution Complex Interactions of Metabolism and Cortical Expansion across Development and Evolution. | Scientific theories on the functioning and dysfunction of the human brain require an understanding of its development-before and after birth and through maturation to adulthood-and its evolution. Here we bring together several accounts of human brain evolution by focusing on the central role of oxygen and brain metabol... |
36,476,106 | Journeying to Ixtlan Ethics of Psychedelic Medicine and Research for Alzheimers Disease and Related Dementias. | In this paper, we examine the case of psychedelic medicine for Alzheimers disease and related dementias (ADADRD). These mind-altering drugs are not currently offered as treatments to persons with ADADRD, though there is growing interest in their use to treat underlying causes and associated psychiatric symptoms. We pre... |
36,475,998 | The Next Day Effects of Cannabis Use A Systematic Review. | null |
36,474,478 | Psychedelics and fNIRS neuroimaging exploring new opportunities. | In this Outlook paper, we explain to the optical neuroimaging community as well as the psychedelic research community the great potential of using optical neuroimaging with functional near-infrared spectroscopy (fNIRS) to further explore the changes in brain activity induced by psychedelics. We explain why we believe n... |
36,473,591 | Role of cyclin-dependent kinase 5 in psychosis and the modulatory effects of cannabinoids. | Cyclin-dependent kinase 5 (CDK5) is a serinethreonine kinase that has emerged as a key regulator of neurotransmission in complex cognitive processes. Its expression is altered in treated schizophrenia patients, and cannabinoids modulate CDK5 levels in the brain of rodents. However, the role of this kinase, and its inte... |
36,469,638 | Exploring Potential Bellwethers for Drug-Related Mortality in the General Population A Case for Sentinel Surveillance of Trends in Drug Use among NightclubFestival Attendees. | null |
36,469,097 | Psilocybin mitigates the cognitive deficits observed in a rat model of Fragile X syndrome. | Fragile X syndrome (FXS) is the most common form of inherited intellectual disability (ID) and the leading monogenic cause of autism spectrum disorder (ASD). Serotonergic neurotransmission has a key role in the modulation of neuronal activity during development, and therefore, it has been hypothesized to be involved in... |
36,467,212 | Music programming for psilocybin-assisted therapy Guided Imagery and Music-informed perspectives. | The psychedelic drug psilocybin has been successfully explored as a novel treatment for a range of psychiatric disorders. Administration of psilocybin requires careful attention to psychological support and the setting in which the drug is administered. The use of music to support the acute psychoactive effects of psil... |
36,465,958 | Classic psychedelics, health behavior, and physical health. | Preliminary evidence suggests that classic psychedelics may be effective in the treatment of some psychiatric disorders, yet little remains known about their effects on health behavior and physical health. The purpose of this study was to investigate associations of lifetime classic psychedelic use and psychological in... |
36,465,766 | The Efficacy of Psychedelic-Assisted Therapy in Managing Post-traumatic Stress Disorder (PTSD) A New Frontier | Post-traumatic stress disorder (PTSD) is a significant public health concern for which existing therapies are only marginally effective. Indisputably, the primary line of treatment for PTSD is psychotherapy, according to current treatment guidelines. However, PTSD continues to be a chronic condition even after psychoth... |
36,465,060 | Genetic support of a causal relationship between cannabis use and educational attainment a two-sample Mendelian randomization study of European ancestry. | Excessive cannabis use may lead to lower educational attainment. However, this association may be due to confounders and reverse causality. We tested the potential causal relationship between cannabis use disorder (CUD) or life-time cannabis use (LCU) and educational attainment. Bidirectional two-sample Mendelian rando... |
36,462,291 | The future of hallucination research Can hallucinogens and psychedelic drugs teach us anything | Hallucinations are one of the most interesting and least understood of all human experiences. This commentary addresses the ideas which most influenced my thinking in the past 20 years and what I believe to be the most currently promising area of enquiry. Interest in hallucinations reaches far back into antiquity and a... |
36,459,874 | Validation of analytical method of cannabinoids Novel approach using turbo-extraction. | The development of simple, efficient, and low-cost analytical methods is essential for the evaluation and monitoring of the main cannabinoids in Cannabis-based products. In this sense, the objectives of this study were to develop and validate an analytical method for obtaining and determining cannabinoids in a pool sam... |
36,459,827 | Assessing the prevalence and risk factors of marijuana use in adults with disabilities. | Public support for the legalization of marijuana (cannabis) for medical or recreational use by adults has grown rapidly over the past two decades. Given the growing prevalence and concerns about potential harms, a better understanding is needed of disparities in marijuana use among adults by disability status. Using 20... |
36,459,169 | Matrix-assisted laser-desorptionionization-mass spectrometric imaging of psilocybin and its analogues in psychedelic mushrooms using a cesium chloride-coated target plate. | Fungi with hallucinogenic properties and neurotoxicity have been listed as prohibited drugs in recent years, but there is a lack of in situ quantification of psilocybin and analogues in these samples to avoid the decomposition of these psychoactive tryptamines in time-consuming sample preparation. In this study, matrix... |
36,458,012 | The β-carboline Harmine improves the therapeutic benefit of anti-PD1 in melanoma by increasing the MHC-I-dependent antigen presentation. | Harmine is a dual-specificity tyrosine-regulated kinase 1A (DYRK1A) inhibitor that displays a number of biological and pharmacological properties. Also referred to as ACB1801 molecule, we have previously reported that harmine increases the presentation of major histocompatibility complex (MHC)-I-dependent antigen on me... |
36,457,321 | Sexualized drug use among men who have sex with men in Madrid and Barcelona The gateway to new drug use | This original study compares the prevalences of drug use for any purpose and for sexualized drug use (SDU) among MSM. It also describes relevant characteristics of first SDU, analyzes to what extent SDU has been the first experience (the gateway) with different drugs by age and explores the correlates of SDU. Study par... |
36,457,139 | Stable isotope characterisation of 3,4-methylenedioxyphenyl-2-propanone and 3,4-methylenedioxyamphetamine prepared from piperonal. | Stable isotopic ratios can provide information for illicit drug profiling. The research presented here investigated the variations in stable isotopic ratios of hydrogen (δ Samples of MDA and MDP2P were synthesised from two isotopically characterised starting materials, piperonal and nitroethane. The isotopic compositio... |
36,456,173 | Underground ibogaine use for the treatment of substance use disorders A qualitative analysis of subjective experiences. | Ibogaine is one of the alkaloids naturally found in plants such as Tabernanthe iboga, which has been traditionally used by members of the Bwiti culture. Since the discovery of its anti-addictive properties by Howard S. Lotsof in 1962, ibogaine has been used experimentally to treat substance use disorders (SUD), especia... |
36,455,646 | Considerations in assessing the abuse potential of psychedelics during drug development. | The recent increase in clinical research on the potential therapeutic uses of classic psychedelics has prompted the need to revisit the assessment of the abuse potential of these drugs. The term classic psychedelic is used in this manuscript to describe serotonergic 5-HT |
36,454,483 | Thin-layer chromatography on silver nitrate-impregnated silica gel for analysis of homemade tetrahydrocannabinol mixtures. | Various forms of cannabidiol (CBD)-containing products are sold in Japan. CBD is easily converted to mixtures of ∆ To evaluate potential separation ability, standards of five THC isomers (∆ System A showed clear separation between the five THC isomers and between ∆ AgNO |
36,454,414 | High-sensitivity method for the determination of LSD and 2-oxo-3-hydroxy-LSD in oral fluid by liquid chromatography‒tandem mass spectrometry. | We have developed and validated a high-sensitivity method to quantify lysergic acid diethylamide (LSD) and 2-oxo-3-hydroxy-LSD (OH-LSD) in oral fluid samples using liquid-liquid extraction and liquid chromatography-tandem mass spectrometry (LC‒MSMS). The method was applied to the quantification of both substances in 42... |
36,453,437 | Cannabinoid Poisoning-Related Emergency Department Visits and Inpatient Hospitalizations in Kentucky, 2017 to 2019. | null |
36,452,396 | Self-transcendent experiences as promoters of ecological wellbeing Exploration of the evidence and hypotheses to be tested. | In recent years, much has been written on the role of different mental states and their potential to influence our way of thinking and, perhaps more importantly, the way we act. With the recent acceleration of environmental and mental health issues, alongside the limited effectiveness of existing interventions, an expl... |
36,452,124 | Analgesic potential of macrodoses and microdoses of classical psychedelics in chronic pain sufferers a population survey. | Although several studies and reports have shown the potential analgesic use of serotonergic psychedelics in cancer pain, phantom limb pain and cluster headache, evidence supporting their use for chronic pain is still limited. The past years have seen a considerable renewal of interest toward the therapeutic use of thes... |
36,449,315 | Clinical Trial Design Challenges and Opportunities for Emerging Treatments for Opioid Use Disorder A Review. | Novel treatments for opioid use disorder (OUD) are needed to address both the ongoing opioid epidemic and long-standing barriers to existing OUD treatments that target the endogenous μ-opioid receptor (MOR) system. The goal of this review is to highlight unique clinical trial design considerations for the study of emer... |
36,449,286 | Smoking Behaviors and Prognosis in Patients With Non-Muscle-Invasive Bladder Cancer in the Be-Well Study. | Tobacco smoking is an established risk factor associated with bladder cancer, yet its impact on bladder cancer prognosis is unclear. To examine associations of use of tobacco (cigarettes, pipes, and cigars), e-cigarettes, and marijuana with risk of recurrence and progression of non-muscle-invasive bladder cancer (NMIBC... |
36,446,608 | Maternal and Fetal Exposure to (-)-Δ | (-)-Δ |
36,445,753 | Trends in cannabis use intention around the period of cannabis legalisation in Australia An age-period-cohort model. | This study examines age, time period and birth cohort trends in cannabis use intention and weekly use in Australia over a period in which medicinal cannabis was legalised. Hierarchical age-period-cohort models were used to analyse the National Drug Strategy Household Survey between 2001 and 2019, including 158,395 part... |
36,445,706 | Geographic Accessibility of Retail Cannabis in Northern California and Prenatal Cannabis Use During the COVID-19 Pandemic. | Prenatal cannabis use is associated with health risks for mothers and their children. Prior research suggests that rates of prenatal cannabis use in Northern California increased during the COVID-19 pandemic, but it is unknown whether increases varied with the local cannabis retail and policy environment. To test wheth... |
36,445,079 | DNA Authentication and Chemical Analysis of | The mushroom genus |
36,443,987 | Cannabis use, risk behaviours and harms in Brazil A comprehensive review of available data indicators. | Cannabis use and related healthsocial outcome indicator data for Brazil-where non-medical cannabis is generally illegal-are limited. Towards a comprehensive overview of relevant indicators, we searched primary databases by combining MeSH-index terms related to cannabis, geographic location and subtopic terms (e.g., use... |
36,441,710 | Thalamocortical functional connectivity and cannabis use in men with childhood attention-deficithyperactivity disorder. | Disruptions of the cortico-striato-thalamo-cortical circuit has been implicated in both attention-deficithyperactivity disorder and substance use disorder. Given the high prevalence of cannabis use among patients with attention-deficithyperactivity disorder, we set out to investigate the relationship between the two in... |
36,440,853 | What We Have Gained from Ibogaine α3β4 Nicotinic Acetylcholine Receptor Inhibitors as Treatments for Substance Use Disorders. | For decades, ibogaine─the main psychoactive alkaloid found in |
36,440,420 | MDMA for the treatment of misophonia, a proposal. | Misophonia is a disorder characterized by negative physical and emotional reactions to certain trigger sounds, such as chewing food. Up to 50% of population samples endorse some symptoms of misophonia, with about 20% having symptoms that impair normal life functioning. Most misophonia patients exhibit intense negative ... |
36,437,760 | Antitumorigenic Effect of Cannabidiol in Lung Cancer What Do We Know So Far–A Mini Review. | Lung cancer remains a major factor contributing to morbidity and mortality worldwide. cannabidiol (CBD) and Δ9-tetrahydrocannabinol could serve as a specific treatment for lung cancer, owing to their essential role in lung cancer cell apoptosis. This review evaluated the antitumorigenic mechanisms of CBD in lung cancer... |
36,434,963 | Liquid chromatography-tandem mass spectrometry method for the bioanalysis of N,N-dimethyltryptamine (DMT) and its metabolites DMT-N-oxide and indole-3-acetic acid in human plasma. | The indole alkaloid N,N-dimethyltryptamine (DMT) induces psychedelic effects in humans. In addition to ceremonial and recreational use, DMT is subject to clinical investigations. Sensitive bioanalytical methods are required to assess the pharmacokinetics of DMT and its metabolites in human plasma. Here, a high performa... |
36,434,879 | Alleviation of opioid withdrawal by cannabis and delta-9-tetrahydrocannabinol A systematic review of observational and experimental human studies. | While six U.S. states have already officially authorized cannabinoids to substitute opioids and treat opioid use disorder, the therapeutic benefits of cannabinoids remain unclear, especially when weighted against their adverse effects. We conducted a systematic review of studies examining the association between opioid... |
36,433,778 | Changes in music-evoked emotion and ventral striatal functional connectivity after psilocybin therapy for depression. | Music listening is a staple and valued component of psychedelic therapy, and previous work has shown that psychedelics can acutely enhance music-evoked emotion. The present study sought to examine subjective responses to music before and after psilocybin therapy for treatment-resistant depression, while functional magn... |
36,430,623 | Role of 5-HT2A, 5-HT2C, 5-HT1A and TAAR1 Receptors in the Head Twitch Response Induced by 5-Hydroxytryptophan and Psilocybin Translational Implications. | There is increasing interest in the therapeutic potential of psilocybin. In rodents, the serotonin precursor, 5-hydroxytryptophan (5-HTP) and psilocybin induce a characteristic 5-HT2A receptor (5-HT2AR)-mediated head twitch response (HTR), which is correlated with the human psychedelic trip. We examined the role of oth... |
36,430,546 | Extensive Collection of Psychotropic Mushrooms with Determination of Their Tryptamine Alkaloids. | Since not only psilocybin (PSB) but also PSB-containing mushrooms are used for psychedelic therapy and microdosing, it is necessary to know their concentration variability in wild-grown mushrooms. This article aimed to determine the PSB, psilocin (PS), baeocystin (BA), norbaeocystin (NB), and aeruginascin (AE) concentr... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.