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36,897,581 | Adjustment for Social Risk Factors in a Measure of Clinician Quality Assessing Acute Admissions for Patients With Multiple Chronic Conditions. | Adjusting quality measures used in pay-for-performance programs for social risk factors remains controversial. To illustrate a structured, transparent approach to decision-making about adjustment for social risk factors for a measure of clinician quality that assesses acute admissions for patients with multiple chronic... |
36,897,543 | Cerebral Hemodynamics Underlying Artery-to-Artery Embolism in Symptomatic Intracranial Atherosclerotic Disease. | Artery-to-artery embolism (AAE) is a common stroke mechanism in intracranial atherosclerotic disease (ICAD), associated with a considerable risk of recurrent stroke. We aimed to investigate cerebral hemodynamic features associated with AAE in symptomatic ICAD. Patients with anterior-circulation, symptomatic ICAD confir... |
36,897,542 | Residual risks and evolving atherosclerotic plaques. | Atherosclerotic disease of the coronary and carotid arteries is the primary global cause of significant mortality and morbidity. The chronic occlusive diseases have changed the epidemiological landscape of health problems both in developed and the developing countries. Despite the enormous benefit of advanced revascula... |
36,897,464 | Is the robotic rehabilitation that is added to intensive body rehabilitation effective for maximization of upper extremity motor recovery following a stroke A randomized controlled study. | Trunk stabilization, which is a factor that directly affects the performance of affected upper-limb movements in stroke patients, is of critical importance in the performance of selective motor control. This study aimed to investigate the effects on upper-limb motor function of the addition of robotic rehabilitation (R... |
36,897,243 | Effect of phosphodiesterase type 5 inhibitors on major adverse cardiovascular events and overall mortality in a large nationwide cohort of men with erectile dysfunction and cardiovascular risk factors A retrospective, observational study based on healthcare claims and national death index data. | Treatment with phosphodiesterase type 5 inhibitors (PDE-5is) is effective in treating erectile dysfunction (ED). The objective of this study was to determine the effect of PDE-5is on the incidence of major adverse cardiovascular (CV) events (MACE composite outcome of CV death, hospitalization for myocardial infarction,... |
36,897,149 | Risk factors variability and cardiovascular risk among patients with diabetes a nationwide observational study. | Cardiovascular risk factors control is fluctuating, tends to change over time, and is potentially impacted by multifactorial interactions. Currently, the existence of risk factors, rather than their variability or interplay with one another, is used to define the population at risk. The association between variability ... |
36,897,101 | Real-World Outcomes of Endovascular Thrombectomy for Basilar Artery Occlusion Results of the BArONIS Study. | To evaluate clinical outcomes of endovascular thrombectomy (EVT) for acute basilar artery occlusion (BAO) using population-level data from the United States. Weighted discharge data from the National Inpatient Sample were queried to identify adult patients with acute BAO during the period of 2015 to 2019 treated with E... |
36,897,060 | Association between comorbidities and longitudinal changes in total testosterone among men from the Baltimore Longitudinal Study of Aging. | Previous cross-sectional and longitudinal studies have described decreasing testosterone levels with age in men, without consideration of acquired comorbidities in aging males. We evaluated the longitudinal association between age and testosterone levels as well as the impact of several comorbidities on this relationsh... |
36,897,048 | Mecp2 deletion results in profound alterations of developmental and adult functional connectivity. | As a regressive neurodevelopmental disorder with a well-established genetic cause, Rett syndrome and its Mecp2 loss-of-function mouse model provide an excellent opportunity to define potentially translatable functional signatures of disease progression, as well as offer insight into the role of Mecp2 in functional circ... |
36,896,884 | Systematic Review and Meta-Analysis of Ex-Situ and In-Situ Fenestrated Stent-Grafts for Endovascular Repair of Aortic Arch Pathologies. | To gain insight into safety and efficacy of in situ and ex-situ fenestration techniques for total endovascular arch repair. The term ex-situ fenestration is referring to physician-modified stent-graft technique where fenestration is performed on a back table. Electronic search was conducted according to PRISMA (Preferr... |
36,896,833 | Non-homogeneous continuous-time Markov chain with covariates Applications to ambulatory hypertension monitoring. | Hypertension significantly increases the risk for many health conditions including heart disease and stroke. Hypertensive patients often have continuous measurements of their blood pressure to better understand how it fluctuates over the day. The continuous-time Markov chain (CTMC) is commonly used to study repeated me... |
36,896,796 | Long-term outcomes in heart failure with preserved ejection fraction Predictors of cardiac and non-cardiac mortality. | Heart failure (HF) with preserved ejection fraction (HFpEF) is associated with cardiovascular (CV) and non-CV events, but long-term risk is poorly studied. We assessed incidence and predictors of the long-term CV and non-CV events. Patients presenting with acute HF, EF ≥ 45%, and N-terminal pro-brain natriuretic peptid... |
36,896,774 | Prognostic implications of stress hyperglycemia ratio in patients with myocardial infarction with nonobstructive coronary arteries. | The role of stress hyperglycemia in acute myocardial infarction (AMI) has long been emphasized. Recently, the stress hyperglycemia ratio (SHR), a novel index reflecting an acute glycemia rise, has shown a good predictive value in AMI. However, its prognostic power in myocardial infarction with nonobstructive coronary a... |
36,896,637 | Left atrial appendage filling defect in exclusive early-phase scanning of dual-phase cardiac computed tomography an indicator for elevated thromboembolic risk. | Dual-phase cardiac computed tomography (CCT) has been applied to detect left atrial appendage (LAA) thrombosis, which is characterized as the presence of left atrial appendage filling defects (LAADF) in both early- and delayed-phase scanning. However, the clinical implication of LAAFD in exclusive early-phase scanning ... |
36,896,626 | Preclinical Common Data Elements for General Pharmacological Studies (Pharmacokinetic Sample Collection, Tolerability, and Drug Administration). A Report of the TASK3-WG1A General Pharmacology Working Group of the ILAEAES Joint Translational Task Force. | Growing concerns over rigor and reproducibility of preclinical studies, including consistency across laboratories and translation to clinical populations, have triggered efforts to harmonize methodologies. This includes the first set of preclinical common data elements (CDEs) for epilepsy research studies, as well as C... |
36,896,424 | The Impact of Complete Revascularization in Symptomatic Severe Left Ventricular Dysfunction between Coronary Artery Bypass Graft and Percutaneous Coronary Intervention. | The study aimed to compare the clinical outcomes between the patients receiving coronary artery bypass surgery (CABG) or percutaneous coronary intervention (PCI) for the patients with symptomatic severe left ventricular (LV) dysfunction and coronary artery disease (CAD). Between February 2007 and February 2020, a total... |
36,896,382 | Pictorial Essay of Cervical Duplex Ultrasonography. | null |
36,896,363 | Indian Society of Critical Care Medicine Consensus Statement for Prevention of Venous Thromboembolism in the Critical Care Unit. | Deep vein thrombosis (DVT) is a preventable complication of critical illness, and this guideline aims to convey a pragmatic approach to the problem. Guidelines have multiplied over the last decade, and their utility has become increasingly conflicted as the reader interprets all suggestions or recommendations as someth... |
36,896,347 | Depression, anxiety, insomnia, stress, and the way of coping emotions as risk factors for ischemic stroke and their influence on stroke severity A case-control study in Lebanon. | Stroke is a leading cause of disability and death worldwide. There are numerous debates regarding the relationship between depression, anxiety, insomnia, perceived stress, and ischemic stroke. Moreover, no research on the efficacy of emotion regulation, which is critical for various components of healthy affective and ... |
36,896,249 | Standardized tools for assessing balance and mobility in stroke clinical practice guidelines worldwide A scoping review. | Use of standardized tools to assess balance and mobility limitations is a recommended practice in stroke rehabilitation. The extent to which clinical practice guidelines (CPGs) for stroke rehabilitation recommend specific tools and provide resources to support their implementation is unknown. To identify and describe s... |
36,896,226 | Glucagon-Like Peptide 1 Receptor Agonists Versus Sodium-Glucose Cotransporter 2 Inhibitors for Atherosclerotic Cardiovascular Disease in Patients With Type 2 Diabetes. | Beyond improving hemoglobin A1c (HbA1c) in adults with type 2 diabetes, glucagon-like peptide 1 receptor agonists (GLP-1RA) have been approved for reducing risk of major adverse cardiovascular events (MACE) with established cardiovascular disease (CVD) or multiple CV risk factors. Sodium-glucose cotransporter 2 inhibit... |
36,896,224 | The Complexity of Peripheral Arterial Disease and Coronary Artery Disease in Diabetic Patients An Observational Study. | Atherosclerosis is a systemic disease that causes luminal narrowing. Patients with peripheral arterial disease (PAD) also exhibit an increased risk of death from cardiovascular complications. This risk is the same for symptomatic or asymptomatic patients. Over a 5-year period, patients with PAD have a 20% chance of suf... |
36,895,909 | Stroke and the risk of gastrointestinal disorders A Mendelian randomization study. | The issue of whether a stroke is causally related to gastrointestinal disorders was still not satisfactorily understood. Therefore, we investigated if there is a connection between stroke and the most prevalent gastrointestinal disorders, including peptic ulcer disease (PUD), gastroesophageal reflux disease (GERD), irr... |
36,895,904 | Peripheral eosinophil trends and clinical outcomes after non-traumatic subarachnoid hemorrhage. | Uncontrolled systemic inflammation after non-traumatic subarachnoid hemorrhage (SAH) is associated with worse outcomes. Changes in the peripheral eosinophil count have been linked to worse clinical outcomes after ischemic stroke, intracerebral hemorrhage, and traumatic brain injury. We aimed to investigate the associat... |
36,895,903 | A deep learning approach to predict collateral flow in stroke patients using radiomic features from perfusion images. | Collateral circulation results from specialized anastomotic channels which are capable of providing oxygenated blood to regions with compromised blood flow caused by arterial obstruction. The quality of collateral circulation has been established as a key factor in determining the likelihood of a favorable clinical out... |
36,895,902 | Machine learning-based prediction of clinical outcomes after first-ever ischemic stroke. | Accurate prediction of clinical outcomes in individual patients following acute stroke is vital for healthcare providers to optimize treatment strategies and plan further patient care. Here, we use advanced machine learning (ML) techniques to systematically compare the prediction of functional recovery, cognitive funct... |
36,895,900 | Low-dose vs. standard-dose alteplase for Chinese patients with acute ischemic stroke A propensity score analysis. | Previous studies have stimulated debates on low-dose alteplase administration in acute ischemic stroke (AIS) among the Asian population. We sought to evaluate the safety and efficacy of low-dose alteplase in Chinese patients with AIS using a real-world registry. We analyzed data from the Shanghai Stroke Service System.... |
36,895,896 | Bilateral vertebral artery dissection extending to the left posterior cerebral artery A case report. | Intracranial artery dissection accounts for a small percentage (1%-2%) of all ischemic strokes. Vertebral artery dissection sometimes extends to the basilar artery but very rarely to the posterior cerebral artery. We report a case of bilateral vertebral artery dissection extending to the left posterior cerebral artery ... |
36,895,838 | Pregnancy loss and risk of incident CVD within 5 years Findings from the Womens Health Initiative. | Previous studies have demonstrated an increased risk of cardiovascular disease (CVD) in women with a history of pregnancy loss. Less is known about whether pregnancy loss is associated with age at the onset of CVD, but this is a question of interest, as a demonstrated association of pregnancy loss with early-onset CVD ... |
36,895,817 | Risk Factors and Functional Outcomes with Early Neurological Deterioration after Mechanical Thrombectomy for Acute Large Vessel Occlusion Stroke. | Early neurological deterioration (END) is associated with a poor survival after mechanical thrombectomy (MT) in acute ischemic stroke (AIS). To assess risk factors and functional outcomes of END after MT in patients, we analyzed data from 79 patients who received MT with large-vessel occlusion. END after MT in patients... |
36,895,816 | A Comparison of Outcomes Using Combined Intra- and Extradural versus Extradural-Only Repair of Tegmen Defects. | null |
36,895,711 | Creative Art Therapy for Improving Depression, Anxiety, and Stress in Patients with Stroke A Quasi-Interventional Study. | Creative art therapy is a psychotherapeutic approach used to enhance the mental health status of patients. This study aimed to evaluate the effect of creative art therapy on the levels of depression, anxiety, and stress in Jordanian patients following stroke. One-group pretest-posttest design was used it included four ... |
36,895,619 | Current and Novel Therapeutical Approaches of Classical Homocystinuria in Childhood With Special Focus on Enzyme Replacement Therapy, Liver-Directed Therapy and Gene Therapy. | Classical homocystinuria is a hereditary defect of the enzyme cystathionine beta synthase, which is produced in the liver. If this enzyme fails, the synthesis pathway of cysteine from methionine is interrupted, leading to the accumulation of homocysteine in the blood plasma and homocysteine in the urine. After birth, t... |
36,895,511 | Mean Platelet Volume to Platelet Count Ratio Predicts Left Atrial Stasis in Patients with Non-Valvular Atrial Fibrillation. | The mean platelet volume to platelet count ratio (MPVPC) has been investigated in the diagnosis, prognosis and risk stratification in several diseases. However, the predictive role of MPVPC in left atrial stasis (LAS) of non-valvular atrial fibrillation (NVAF) patients remains unknown. A total of 217 consecutive NVAF p... |
36,895,446 | Dementia prevention in memory clinics recommendations from the European task force for brain health services. | Observational population studies indicate that prevention of dementia and cognitive decline is being accomplished, possibly as an unintended result of better vascular prevention and healthier lifestyles. Population aging in the coming decades requires deliberate efforts to further decrease its prevalence and societal b... |
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36,895,362 | Is the excellent air quality a protective factor of health problems for Taitung County in eastern Taiwan Perspectives from visual analytics. | Taitung, an agricultural country in Eastern Taiwan, was famous for its fresh air with less industrial and petrochemical pollution. Air pollution may induce cardiovascular disease, chronic obstructive pulmonary disease (COPD), asthma, and stroke, poor air quality also resulted in a higher depression rate and less feelin... |
36,895,340 | Experience and lessons learned from blunt cerebrovascular injuries A case report. | Blunt cerebrovascular injuries are rare and serious complications of trauma that can lead to cerebral vascular dissection or aneurysm. Improving awareness of blunt cerebrovascular injuries and using computed tomography angiography to pre-screen patients at high risk is recommended by current guidelines to prevent the o... |
36,895,302 | Unexpected paradoxical embolization following catheter-directed thrombectomy with the FlowTriever™ system in a patient with pulmonary embolism a case report. | The optimal therapy for patients suffering from acute pulmonary embolism (PE) classified as intermediate-high risk still needs to be identified. Catheter-directed thrombectomy (CDTE) is a safe procedure to reduce thrombus burden immediately. The lack of randomized trials is one reason catheter-directed thrombolysis (CD... |
36,895,285 | From Molecule to Patient Rehabilitation The Impact of Transcranial Direct Current Stimulation and Magnetic Stimulation on Stroke-A Narrative Review. | Stroke is a major health problem worldwide, with numerous health, social, and economic implications for survivors and their families. One simple answer to this problem would be to ensure the best rehabilitation with full social reintegration. As such, a plethora of rehabilitation programs was developed and used by heal... |
36,895,216 | Controversies and challenges of coil embolization for intracranial aneurysm in a continuous-flow LVAD implanted patient A case report. | Continuous-flow left ventricular assist device (CF-LVAD) technology has rapidly developed to support the failing heart refractory to standard medical treatments. Although the expected prognosis has improved dramatically, ischemic and hemorrhagic strokes are possible complications and the leading causes of death in the ... |
36,895,213 | Traumatic dissection of the anterior cerebral artery secondary to a rugby related impact A case report with emphasis on the usefulness of T1-VISTA. | Cerebrovascular injuries (CVIs) are not usually considered in the differential diagnosis of sport-related head injuries (SRHIs). We encountered a rugby player with traumatic dissection of the anterior cerebral artery (ACA) after impact on the forehead. Head magnetic resonance imaging (MRI) with T1-volume isotropic turb... |
36,895,212 | Herpes simplex virus encephalitis mimicking acute ischemic stroke. | Infections of the central nervous system might present in an acute form such as to be similar with the clinical characteristics of a stroke. This situation will hamper a correct diagnosis and a prompt treatment that can otherwise be successful. We present the case of a herpes virus encephalitis that came up in the emer... |
36,895,190 | Thirty-day and one-year outcomes of the Navitor transcatheter heart valve in patients with aortic stenosis the prospective, multicentre, global PORTICO NG Study. | The Navitor transcatheter heart valve (THV) is a self-expanding valve, with an intra-annular leaflet position and an outer cuff intended to reduce paravalvular leak (PVL). The aim of the PORTICO NG Study is to assess the safety and performance of the Navitor THV in patients with symptomatic, severe aortic stenosis who ... |
36,895,175 | Outflow cannula alignment in continuous flow left ventricular devices is associated with stroke. | We sought to evaluate whether differences in left ventricular assist device (LVAD) canula alignment are associated with stroke. There is a paucity of clinical data on contribution of LVAD canulae alignment to strokes. We conducted a retrospective analysis of patients who underwent LVAD implantation at Houston Methodist... |
36,895,123 | Coexistence of large meningioma and arteriovenous malformationA case report and literature review. | The simultaneous presence of a giant intracranial meningioma and an arteriovenous malformation(AVM)in the same cerebral hemisphere is extremely rare. The treatment should be individualized depending on the case. A 49-year-old man presented with hemiparesis. Preoperative neuroimaging revealed a giant lesion and an AVM o... |
36,895,094 | Genetic propensity for cerebral amyloidosis and risk of mild cognitive impairment and Alzheimers disease within a cognitive reserve framework. | We constructed a polygenic risk score (PRS) for β-amyloid (PRSAβ42) to proxy AD pathology and investigated its association with incident Alzheimers disease (AD)amnestic mild cognitive impairment (aMCI) and the influence of cognitive reserve (CR), proxied by educational years, on the relationship between PRSAβ42 and ADa... |
36,891,251 | Development and feasibility testing of action observation training videos in acute stroke survivors Preliminary findings. | null |
36,895,041 | A 14-year-old boy with multiple trauma and bilateral basal ganglia hemorrhage due to coronavirus disease 2019 a case report. | In December 2019, coronavirus disease 2019 spread worldwide, causing acute respiratory distress syndrome. Coronavirus disease 2019 presents from an asymptomatic infection to severe disease causing multiorgan failure. Neurological manifestations were observed in some patients, including intracerebral hemorrhage. Bilater... |
36,894,947 | GAS6-AS1, a long noncoding RNA, functions as a key candidate gene in atrial fibrillation related stroke determined by ceRNA network analysis and WGCNA. | Stroke attributable to atrial fibrillation (AF related stroke, AFST) accounts for 13 26% of ischemic stroke. It has been found that AFST patients have a higher risk of disability and mortality than those without AF. Additionally, its still a great challenge to treat AFST patients because its exact mechanism at the mole... |
36,894,748 | Spectrum of Complications and Complication Rates After Diagnostic Catheter Angiography in Neuroradiology. | To retrospectively evaluate the total complication rates and type of complications after diagnostic cerebral and spinal catheter angiography. Data from 2340 patients undergoing diagnostic angiography over a period of 10 years in a neuroradiologic center were retrospectively evaluated. Local, systemic, neurological, and... |
36,894,695 | Association between exercise habit changes and incident dementia after ischemic stroke. | We aimed to investigate the effects of exercise habit changes on the risk of incident dementia after ischemic stroke using the Korean National Health Insurance Services Database. This study included 223,426 patients with a new diagnosis of ischemic stroke between 2010 and 2016 who underwent two serial ambulatory health... |
36,894,627 | Sustained overexpression of spliced X-box-binding protein-1 in neurons leads to spontaneous seizures and sudden death in mice. | The underlying etiologies of seizures are highly heterogeneous and remain incompletely understood. While studying the unfolded protein response (UPR) pathways in the brain, we unexpectedly discovered that transgenic mice (XBP1s-TG) expressing spliced X-box-binding protein-1 (Xbp1s), a key effector of UPR signaling, in ... |
36,894,360 | Rationale and design of a randomized controlled pilot trial to assess stent retriever thrombectomy for thrombus burden reduction in patients with acute myocardial infarction The RETRIEVE-AMI study. | ST-elevation myocardial infarction (STEMI) is typically caused by thrombotic occlusion of a coronary artery with subsequent hypoperfusion and myocardial necrosis. In approximately half of patients with STEMI, despite successful restoration of epicardial coronary patency, downstream myocardium perfusion remains impeded.... |
36,894,350 | Early and long-term outcomes of bioprosthetic versus mechanical tricuspid valve replacement A nationwide population-based study. | We compared early and long-term clinical outcomes of bioprosthetic versus mechanical tricuspid valve replacement in a nationwide study based on the database from the National Health Insurance Service. Of 1425 patients who underwent tricuspid valve replacement from 2003 to 2018, 1241 patients were enrolled after excludi... |
36,894,122 | Does left atrial appendage morphology and dimension differ amongst etiological stroke subtypes in patients without known Atrial Fibrillation Results from the Left Atrial Appendage morphology and dimension assessment by TEE in patients with stroke without known Atrial Fibrillation (LAMDA-STROKE) Study.. | Complex left atrial appendage (LAA) morphology is increasingly associated with cryptogenic ischemic stroke as compared to cardioembolic stroke due to atrial fibrillation (AF). However, data on such an association in patients with other etiological stroke subtypes in the absence of AF is limited. The study aimed to asse... |
36,894,102 | Long-term exposure to fine particulate matter and cardiovascular disease The mitigation role of environmental concerns. | Although it is widely acknowledged that environmental concerns can reduce PM |
36,893,948 | Identification and characterization of new candidates for abdominal aortic aneurysm screening in patients outside of current accepted guidelines. | Previous studies have identified groups of patients with abdominal aortic aneurysm (AAA) that fall outside of currently accepted screening guidelines. Population-based studies have found AAA screening would be cost-effective at a prevalence of 0.5-1%. The goal of this study was to determine the prevalence of AAA in pat... |
36,893,934 | Identifying treatment heterogeneity in atrial fibrillation using a novel causal machine learning method. | Lifelong oral anticoagulation is recommended in patients with atrial fibrillation (AF) to prevent stroke. Over the last decade, multiple new oral anticoagulants (OACs) have expanded the number of treatment options for these patients. While population-level effectiveness of OACs has been compared, it is unclear if there... |
36,893,911 | Stroke-induced hexokinase 2 in circulating monocytes exacerbates vascular inflammation and atheroprogression. | Stroke accelerates inflammatory monocyte recruitment to the endothelium and consequent atheroprogression via high-mobility group box 1-receptor for advanced glycation end products (Hmgb1-RAGE) signaling. Notably, Hmgb1 interacts with multiple Toll-like receptors (TLRs) and promotes TLR4-mediated pro-inflammatory myeloi... |
36,893,841 | Not Available. | Acute pulmonary embolism (PE) is a major cause of morbidity and mortality in Portugal. It is the third most common cause of cardiovascular death after stroke and myocardial infarction. However, the management of acute PE remains poorly standardized, and there is a lack of access to mechanical reperfusion when indicated... |
36,893,823 | An MMP-9 exclusive neutralizing antibody attenuates blood-brain barrier breakdown in mice with stroke and stroke patient-derived MMP-9 activity. | Rapid upregulation of matrix metalloproteinase 9 (MMP-9) leads to blood-brain barrier (BBB) breakdown following stroke, but no MMP-9 inhibitors have been approved in clinic largely due to their low specificities and side effects. Here, we explored the therapeutic potential of a human IgG monoclonal antibody (mAb), L13,... |
36,893,798 | Ozone pollution and hospital admissions for cardiovascular events. | The available literature on morbidity risk of cardiovascular diseases associated with ambient ozone pollution is still limited. This study examined the potential acute effects of exposure to ambient ozone pollution on hospital admissions of cardiovascular events in China. A two-stage multi-city time-series study approa... |
36,893,755 | Choroid plexus-targeted NKCC1 overexpression to treat post-hemorrhagic hydrocephalus. | Post-hemorrhagic hydrocephalus (PHH) refers to a life-threatening accumulation of cerebrospinal fluid (CSF) that occurs following intraventricular hemorrhage (IVH). An incomplete understanding of this variably progressive condition has hampered the development of new therapies beyond serial neurosurgical interventions.... |
36,893,741 | Increased Two-Hour Post-Load Plasma Glucose Fluctuation Corresponds with Worse Clinical Prognoses among Acute Ischemic Stroke Patients without a History of Diabetes Mellitus. | This study aimed to evaluate the relationship between 2-h post-load minus fasting plasma glucose (2hPG-FPG) and 1-year clinical outcomes, such as death, stroke recurrence, and modified Rankin Scale (mRS) ≥2-3 among acute ischemic stroke (AIS) patients without diabetes mellitus (DM) history. 1,214 AIS patients without D... |
36,893,661 | Segmentation of acute stroke infarct core using image-level labels on CT-angiography. | Acute ischemic stroke is a leading cause of death and disability in the world. Treatment decisions, especially around emergent revascularization procedures, rely heavily on size and location of the infarct core. Currently, accurate assessment of this measure is challenging. While MRI-DWI is considered the gold standard... |
36,893,513 | Mechanical thrombectomy for acute large vessel occlusion stroke beyond 24 h. | Multiple trials have shown that mechanical thrombectomy (MT) is superior to medical therapy. However, no robust evidence is available regarding MT beyond 24 h. In this study, we aimed to determine the safety and efficacy of endovascular stroke therapy in this late window. We conducted a retrospective study of prospecti... |
36,893,382 | Interhemispheric Asymmetries in Intracortical Facilitation Correlate With Fatigue Severity in Individuals With Poststroke Fatigue. | Poststroke fatigue (PSF) contributes to increased mortality and reduces participation in rehabilitative therapy. Although PSFs negative influences are well known, there are currently no effective evidence-based treatments for PSF. The lack of treatments is in part because of a dearth of PSF pathophysiological knowledge... |
36,893,378 | Outpatient EEG in Routine Clinical Care of Patients With Stroke-Related Acute Symptomatic Seizure Concerns. | Acute symptomatic seizures (ASyS) after stroke contribute the highest risk to poststroke epilepsy (PSE) development. We investigated the use of outpatient EEG (oEEG) among stroke patients with ASyS concerns. Adults with acute stroke, ASyS concerns (underwent cEEG), and outpatient clinical follow-up were included (study... |
36,893,103 | Clinical criteria to exclude acute vascular pathology on CT angiogram in patients with dizziness. | Patients presenting to the emergency department (ED) with dizziness may be imaged via CTA head and neck to detect acute vascular pathology including large vessel occlusion. We identify commonly documented clinical variables which could delineate dizzy patients with near zero risk of acute vascular abnormality on CTA. W... |
36,893,099 | In-hospital stress and patient outcomes A systematic review and meta-analysis. | Hospital inpatients are exposed to high levels of stress during hospitalisation that may increase susceptibility to major adverse health events post-hospitalisation (known as post-hospital syndrome). However, the existing evidence base has not been reviewed and the magnitude of this relationship remains unknown. Theref... |
36,893,079 | The impact of visuospatial and executive function on activity performance and outcome after robotic or conventional gait training, long-term after stroke-as part of a randomized controlled trial. | Visuospatial and executive impairments have been associated with poor activity performance sub-acute after stroke. Potential associations long-term and in relation to outcome of rehabilitation interventions need further exploration. To explore associations between visuospatial and executive function and 1) activity per... |
36,893,016 | Elevated levels of total homocysteine after ischemic stroke a potential marker for in-hospital outcomes. | Our goal was to determine the risk conferred by elevated total homocysteine (tHcy) levels on recurrent stroke and cardiovascular disease (CVD) events after an ischemic stroke (IS), using data from the Chinese Stroke Center Alliance (CSCA). The study consisted of 746,854 total participants with IS. Subjects were split i... |
36,893,015 | Deep isoflurane anesthesia is associated with alterations in ion homeostasis and specific NaK-ATPase impairment in the rat brain. | Maintenance of ion homeostasis is essential for normal brain function. Inhalational anesthetics are known to act on various receptors but their effects on ion homeostatic systems, such as the NaK-ATPase, remain largely unexplored. Based on reports demonstrating global network activity and wakefulness modulation by inte... |
36,892,998 | Synaptotagmin-3 interactions with GluA2 mediate brain damage and impair functional recovery in stroke. | Synaptotagmin III (Syt3) is a Ca |
36,892,855 | Interprofessional Education Through a Monthly Stroke Support Group. | Interprofessional education (IPE) is an accreditation requirement in many health professional programs. A semester-long community-based stroke support group was designed with participation from faculty and health professional students in the occupational therapy, physical therapy, speech and language pathology, and the... |
36,892,728 | MiR-17-5p Mediates the Effects of ACE2-Enriched Endothelial Progenitor Cell-Derived Exosomes on Ameliorating Cerebral Ischemic Injury in Aged Mice. | Aging is one of the key mechanisms of vascular dysfunction and contributes to the initiation and progression of ischemic stroke (IS). Our previous study demonstrated that ACE2 priming enhanced the protective effects of exosomes derived from endothelial progenitor cells (EPC-EXs) on hypoxia-induced injury in aging endot... |
36,892,672 | Nootropic Activity of Prospekta in a Blind Placebo-Controlled Study in a Model of Focal Cerebral Ischemia in Rats. | Analysis of the pharmacological activity of the original drug Prospekta in a rat model of focal cerebral ischemia revealed its nootropic effect course treatment in the post-ischemic period led to recovery of the neurological status of animals at the peak of neurological deficit. Evaluation of the therapeutic potential ... |
36,892,520 | Lower-extremity constraint-induced movement therapy improved motor function, mobility, and walking after stroke. | To regain the ability to walk is one of the most commonly stated goals for people who have had a stroke due to its importance in everyday life. Walking ability affects patients mobility, self-care, and social lives. Constraint-induced movement therapy (CIMT) is known to be effective in improving upper extremity outcome... |
36,892,446 | Risk-related clinical outcomes after minimally invasive mitral valve surgery insights from the mini-mitral international registry (MMIR). | With the popularization of catheter-based mitral valve procedures, evaluating risk-specific differentiated clinical outcomes after contemporary mitral valve surgery is crucial. In this study, we assessed the operative results of minimally invasive mitral valve operations across different patient risk profiles and evalu... |
36,892,435 | Left Atrial Appendage Amputation concomitant to Cardiac Surgery in Patients with Sinus Rhythm. | Since recent data demonstrated the benefit of left atrial appendage (LAA) amputation in patients with atrial fibrillation, the long-term impact of LAA amputation on stroke rate and mortality in patients with no history of atrial fibrillation is still unknown. Patients with no history of atrial fibrillation who underwen... |
36,892,301 | Characteristics of stroke-like lesions on cerebral imaging. | <p><strong>Objective<strong> ndash Stroke-like lesions (SLLs) are pathognomonic for mitochondrial enceshyphashylopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome but occur in other mitochondrial and non-mitochondrial disorders as well. This mini-review aims at summarising and discussing recent findings... |
36,892,300 | The effects of mindfulness-based interventions in post-stroke rehabilitation. | <p>Stroke is nowadays one of the most prevalent diseases worldwide causing devastating impairments and negative consequences for survivors. It is a main cause of adult onset disability and it can have a negative impact on psychological health, cognitive function and quality of life. Post-stroke rehabilitation may reduc... |
36,892,196 | Mechanisms underlying the effect of voluntary running on adult hippocampal neurogenesis. | Adult hippocampal neurogenesis is important for preserving learning and memory-related cognitive functions. Physical exercise, especially voluntary running, is one of the strongest stimuli to promote neurogenesis and has beneficial effects on cognitive functions. Voluntary running promotes exit of neural stem cells (NS... |
36,892,123 | Choice and Timing of Antithrombotic After Ischemic Stroke, Intracerebral Hemorrhage or Cerebral Venous Thrombosis. | Stroke is a multifactorial vascular disease and remains a leading cause of disability in the United States. Strokes can be ischemic or hemorrhagic in nature and secondary to arterial or venous disease, making determining the etiology and secondary prevention strategy important for preservation of the injured brain, pre... |
36,892,077 | Variability in Nonvitamin K Oral Anticoagulant Dose Eligibility and Adjustment According to Renal Formulae and Clinical Outcomes in Patients With Atrial Fibrillation With and Without Chronic Kidney Disease Insights From ORBIT-AF II. | Background Nonvitamin K oral anticoagulants require dose adjustment based on kidney function.The most common estimate of kidney function employed in clinical practice is estimated glomerular filtration rate (eGFR) however, product monographs recommend the use of the Cockcroft-Gault estimated creatinine clearance (eCrCl... |
36,892,072 | Role of Polymorphonuclear Myeloid-Derived Suppressor Cells and Neutrophils in Ischemic Stroke. | Background Immune cells play a vital role in the pathology of ischemic stroke. Neutrophils and polymorphonuclear myeloid-derived suppressor cells share a similar phenotype and have attracted increasing attention in immune regulation research, yet their dynamics in ischemic stroke remain elusive. Methods and Results Mic... |
36,892,027 | The effect of statins on the differentiation and function of central nervous system cells. | Statins (3-hydroxy-3-methylglutaryl-CoA reductase inhibitors) reduce plasma cholesterol and improve endothelium-dependent vasodilation, inflammation, and oxidative stress. The effect of statins on the central nervous system (CNS), particularly on cognition and neurological disorders such as cerebral ischemic stroke, mu... |
36,892,020 | Neutrophil Extracellular Traps in Cerebral IschemiaReperfusion Injury Friend and Foe. | Cerebral ischemic injury, one of the leading causes of morbidity and mortality worldwide, triggers various central nervous system (CNS) diseases, including acute ischemic stroke (AIS) and chronic ischemia-induced Alzheimers disease (AD). Currently, targeted therapies are urgently needed to address neurological disorder... |
36,891,929 | What is resistant arterial hypertension | The current review is to describe the definition and prevalence of resistant arterial hypertension (RAH), the difference between refractory hypertension, patient characteristics and major risk factors for RAH, how RAH is diagnosed, prognosis and outcomes for patients. According to the WHO, approximately 1.28 billion ad... |
36,891,906 | Frequency and Size of In Situ Thrombus Within Patent Foramen Ovale. | High-resolution optical coherence tomography can detect in situ thrombi within patent foramen ovale (PFO), which can become a dangerous embolic source. This study aimed to investigate the frequency and size of in situ thrombus within PFO using optical coherence tomography. The cross-sectional study was conducted at Fuw... |
36,891,905 | Genetically Proxied CRP (C-Reactive Protein) Levels and Lobar Intracerebral Hemorrhage Risk. | Recent evidence suggests that higher CRP (C-reactive protein) levels are associated with lower risk of Alzheimer disease, speculating that CRP might be involved in Aβ clearance mechanisms. Testing this hypothesis, we explored whether genetically proxied CRP levels are also associated with lobar intracerebral hemorrhage... |
36,891,895 | Ablation of Ventricular Preexcitation to Cure Preexcitation-Induced Dilated Cardiomyopathy in Infants Diagnosis and Outcome. | To investigate the clinical features of preexcitation-induced dilated cardiomyopathy in infants and evaluate safety and efficacy of radiofrequency ablation (RFCA) in these patients. This study included 10 infants (4 males and 6 females) with mean age of 6.78±3.14 months, mean weight of 8.11±1.71 kg, and mean left ventr... |
36,891,870 | Impaired gating of γ- and ε-AChR respectively causes Escobar syndrome and fast-channel myasthenia. | To dissect the kinetic defects of acetylcholine receptor (AChR) γ subunit variant in an incomplete form of the Escobar syndrome without pterygium and compare it with those of a variant of corresponding residue in the AChR ε subunit in a congenital myasthenic syndrome (CMS). Whole exome sequencing, α-bungarotoxin bindin... |
36,891,829 | Knockdown of A20 attenuates microglial susceptibility to OGDR-induced ferroptosis and upregulates inflammatory responses. | The A20 protein is considered to have a potent anti-inflammatory effect, but its mechanism of action in the regulation of ferroptosis and inflammation after stroke is still unknown. In this study, the A20-knockdown BV2 cell line (sh-A20 BV2) was constructed at first, and the oxygen-glucose deprivationre-oxygenation (OG... |
36,891,765 | Systematic Review and Meta-Analysis of the Outcome of Different Treatments for Innominate Artery Stenosis or Occlusion. | The present study reported the outcomes of different treatments for innominate artery (IA) atherosclerotic stenosis or occlusion. We performed a systematic review of the literature (4 database searched last search February 2022), including articles with ≥5 patients. We performed meta-analyses of proportions for differe... |
36,891,666 | Causal association of cardiovascular disease with erectile dysfunction A two-sample bidirectional Mendelian randomization analysis. | The association between cardiovascular diseases (CVD), including ischemic stroke (IS), heart failure (HF), myocardial infarction (MI), and coronary heart disease (CHD), and erectile dysfunction (ED) remains unclear from observational studies. We explored the potential bidirectional association between CVD and ED by Men... |
36,891,664 | Meta-analysis and meta-regression of the total endovascular aortic repair in aortic arch. | null |
36,891,635 | Favorable Remodeling After TEVAR in Uncomplicated Acute and Subacute Type B Aortic Dissection in Comparison to Conservative Treatment A Midterm Analysis. | The purpose of the study was to evaluate the midterm and long-term outcomes of patients who underwent thoracic endovascular aortic repair (TEVAR) procedure to treat an uncomplicated acute and subacute type B aortic dissection (uATBAD) with high risk for subsequent aortic complications compared with the group of patient... |
36,891,624 | KARER intervention on care ability and burden for caregiving relatives of disabled patients with cardiocerebrovascular diseases EMICARE mixed randomized clinical protocol. | Determine efficacy of KARER educational intervention on caring ability and burden of caregiving relatives of disabled patients with stroke and cardiovascular diseases. Clinical, randomized, controlled and double blinded trial with a mixed approach. Study population will be made up of 96 caregiving relatives of patients... |
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