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36,881,169 | Clinical outcomes in heart failure patients with and without atrial fibrillation receiving sodium-glucose cotransporter-2 inhibitor. | We report a retrospective analysis of a nationwide health database to study the association between sodium-glucose cotransporter-2 inhibitor (SGLT2I) use and the incidence of adverse clinical outcomes among heart failure (HF) patients with and without atrial fibrillation (AF) stratified by CHA2DS2-VASc score. The outco... |
36,881,162 | Application of the 1-2-3-4-day rule to stroke severity at baseline versus at 24 h to start direct oral anticoagulant for atrial fibrillation within 7 days from symptom onset. | The aim of this study is to compare the 1-2-3-4-day rule applied to stroke severity at baseline versus at 24 h to start DOAC for AF within 7 days from symptom onset. We conducted a prospective cohort observational study based on 433 consecutive AF-related stroke patients starting DOAC within 7 days from symptom onset. ... |
36,881,121 | Percutaneous transluminal angioplasty andor stenting for the treatment of basilar artery stenosis a systematic review and meta-analysis. | Basilar artery stenosis (BAS) carries high morbidity and mortality, with variable outcomes after endovascular treatments. We systematically reviewed the literature on percutaneous transluminal angioplasty andor stenting (PTAS) for BAS. PubMed, EMBASE, Web-of-Science, Scopus, and Cochrane were searched upon the PRISMA g... |
36,881,086 | Physiotherapy Efficiency in Post-stroke Upper Extremity Spasticity TENS | Post-stroke spasticity is a significant debilitating condition with negative consequences on individual functional independence and quality of life. This study aimed to identify the differences between transcutaneous electrical stimulation (TENS), ultrasound therapy and paraffin procedures on post-stroke upper extremit... |
36,880,855 | Prognostic performance of serum YKL-40 for one-year clinical outcomes in acute ischemic stroke. | Effects of YKL-40 on one-year clinical outcomes including poor clinical outcome, all-cause mortality, and stroke recurrence among acute ischemic stroke (AIS) patients remained elusive. The purpose of this study was to explore the association between serum YKL-40 at admission and one-year clinical outcomes in AIS patien... |
36,880,851 | Longitudinal wall shear stress evaluation using centerline projection approach in the numerical simulations of the patient-based carotid artery. | In this numerical study, areas of the carotid bifurcation and of a distal stenosis in the internal carotid artery are closely observed to evaluate the patients current risks of ischemic stroke. An indicator for the vessel wall defects is the stress exerted by blood on the vessel tissue, typically expressed by the ampli... |
36,880,849 | Modulation of bodily response to chill stimuli by impaired structural connectivity of the left insula- a functional and lesion quantification study in stroke patients. | The insula has important function in monitoring and integrating physiological responses to a personal experience of multimodal input. The experience of chills in response to auditory stimuli is an important example for a relevant arousing experience coupled with bodily response. A group study about altered chill experi... |
36,880,803 | N-terminal truncated cardiac troponin I enhances Frank-Starling response by increasing myofilament sensitivity to resting tension. | Cardiac troponin I (cTnI) of higher vertebrates has evolved with an N-terminal extension, of which deletion via restrictive proteolysis occurs as a compensatory adaptation in chronic heart failure to increase ventricular relaxation and stroke volume. Here, we demonstrate in a transgenic mouse model expressing solely N-... |
36,880,639 | Cardiac patterns for differentiation of neurogenic stunned myocardium in aneurysmal subarachnoid hemorrhage versus acute ischemic stroke. | Neurogenic stunned myocardium (NSM) has heterogeneous presentations for acute ischemic stroke (AIS) and aneurysmal subarachnoid hemorrhage (SAH). We sought to better define NSM and differences between AIS and SAH by evaluating individual left ventricular (LV) functional patterns by speckle tracking echocardiography (ST... |
36,880,556 | Neurological complications of critically ill COVID-19 patients. | COVID-19 and systemic critical illness are both associated with neurological complications. We provide an update on the diagnosis and critical care management of adult patients with neurological complications of COVID-19. Large prospective multicentre studies conducted in the adult population over the last 18 months im... |
36,880,555 | Transfusion medicine approaches for spontaneous intracerebral hemorrhage patients. | Spontaneous intracerebral hemorrhage (ICH) is the deadliest stroke subtype. Acute treatments necessitate rapid hemorrhage control to minimize secondary brain injury. Here, we discuss the overlap of transfusion medicine and acute ICH care relating to diagnostic testing and therapies relevant for coagulopathy reversal an... |
36,880,515 | Ischemic stroke caused by spontaneous anterior circulation intracranial arterial dissections patient series. | Intracranial arterial dissections (IADs) are classically associated with the vertebrobasilar system, yet are a devastating cause of ischemic stroke within the anterior circulation. Current literature regarding the surgical management of anterior circulation IAD is lacking. As a result, data on 9 patients presenting wit... |
36,880,378 | Differences in Myocardial Remodeling and Tissue Characteristics in Chronic Isolated Aortic and Mitral Regurgitation. | The left ventricular hemodynamic load differs between aortic regurgitation (AR) and primary mitral regurgitation (MR). We used cardiac magnetic resonance to compare left ventricular remodeling patterns, systemic forward stroke volume, and tissue characteristics between patients with isolated AR and isolated MR. We asse... |
36,880,333 | One-year outcomes after transcatheter aortic valve implantation with the latest-generation SAPIEN balloon-expandable valve the S3U registry. | Initial data about the performance of the new-generation SAPIEN 3 Ultra (S3U) valve are highly promising. However, evidence about the longer-term performance and safety of the S3U is scarce. We aimed to investigate the 1-year clinical and echocardiographic outcomes of transcatheter aortic valve implantation (TAVI) usin... |
36,880,290 | Intravenous thrombolysis versus antiplatelet therapy in minor stroke patients with large vessel occlusion. | Our study aimed to explore the effectiveness and safety of intravenous t-PA compared with dual antiplatelet therapy (DAPT) and aspirin alone for minor stroke with National Institutes of Health Stroke Scale (NIHSS) score ≤5 and large vessel occlusion (LVO). Patients with minor stroke harboring LVO within 4.5-h time wind... |
36,880,201 | Outcomes of endovascular repair of infrarenal penetrating aortic ulcers. | null |
36,880,143 | Comparative assessment of the effects of dobutamine and levosimendan on right ventricular ejection fraction in patients with biventricular heart failure. | Aim The primary objective of this study was to comparatively assess the effects of levosimendan and dobutamine on RVEF, right ventricular diastolic function, and hormonal balance in patients with biventricular heart failure. The secondary objective was to investigate the relationship between the RVEF and the peak systo... |
36,880,138 | Cardiovascular effects of omega-3 polyunsaturated fatty acids position of omega-3 polyunsaturated fatty acids in Russian and international guidelines. Council of Experts. | This Expert Council focuses on the meta-analysis of studies on the risk of atrial fibrillation (AF) in patients taking omega-3 polyunsaturated fatty acids (PUFA) and of data on the omega-3 PUFA treatment in patients with cardiovascular and kidney diseases.The major statements of the Expert Council the meta-analysis of ... |
36,880,137 | Risk Assessment of Adverse Outcomes in Symptomatic Patients With Arterial Hypertension and Chronic Heart Failure With Preserved Ejection Fraction Using THE HFA-PEFF Algorithm. | Aim To study the incidence of heart failure (HF) in patients with arterial hypertension (AH), symptoms of HF, and left ventricular ejection fraction (LV EF) ≥50 % using a novel, modified HFA-PEFF diagnostic algorithm and to evaluate the liver hydration status and density depending on the established HF profiles and the... |
36,880,119 | Efficacy of mirror therapy on lower limb motor recovery, balance and gait in subacute and chronic stroke A systematic review. | Mirror therapy (MT) has been proposed to be an effective therapeutic regimen for lower limb stroke rehabilitation. This review is the first to evaluate the efficacy of MT in subacute and chronic stroke for lower-limb motor functions, balance and gait focusing on particular stage of stroke with specific outcome measures... |
36,880,077 | Sex Differences in Stress-Induced (Takotsubo) Cardiomyopathy. | Takotsubo cardiomyopathy (TC) affects predominantly women. Prior studies have suggested that men might have worse short-term outcomes, but limited data are available regarding long-term outcomes. We hypothesized that men, compared to women, with TC have worse short- and long-term outcomes. A retrospective study of pati... |
36,880,067 | A Survey of Female-Specific Cardiovascular Protocols in Emergency Departments in Canada. | Cardiovascular diseases (CVD) remain the leading cause of death for women. However, systematic inequalities exist in how women experience clinical cardiovascular (CV) policies, programs, and initiatives. In collaboration with the Heart and Stroke Foundation of Canada, a question regarding female-specific CV protocols i... |
36,880,055 | Voluntary running exercise modifies astrocytic population and features in the peri-infarct cortex. | Rehabilitative exercise following a brain stroke has beneficial effects on the morphological plasticity of neurons. Particularly, voluntary running exercise after focal cerebral ischemia promotes functional recovery and ameliorates ischemia-induced dendritic spine loss in the peri-infarct motor cortex layer 5. Moreover... |
36,880,009 | Correlation Between Cardiac Index, Plasma Troponin I, Myocardial Histopathology, CPB and AoX Duration in Glutamine versus No Glutamine Administered Patients with Low Ejection Fraction Undergoing Elective On-Pump CABG Surgery Secondary Analysis of an RCT. | On-pump coronary artery bypass graft (CABG) causes myocardial ischemia, through the cardiopulmonary bypass (CPB) and aortic cross-clamping (AoX). Glutamine supplementation protects cardiac cells during cardiac ischemia. This study analysed the correlation between cardiac index (CI), plasma troponin I, myocardial histop... |
36,879,781 | Stock volatility and hospital admissions for cardiovascular disease results from the National Insurance Claims for Epidemiological Research (NICER) study. | The association between stock volatility and cardiovascular diseases (CVD) was described during the 2008 Global Stock Market Crash however, whether the finding in an occasional stock market crash is spurious remains unclear. A time-series design was used to evaluate the association between short-term exposure to daily ... |
36,879,780 | Projections of future coronary heart disease and stroke mortality in Japan until 2040 a Bayesian age-period-cohort analysis. | We aimed to estimate the future burden of coronary heart disease (CHD) and stroke mortalities by sex and all 47 prefectures of Japan until 2040 while accounting for effects of age, period, and cohort and integrating them to be at the national level to account for regional differences among prefectures. We estimated fut... |
36,879,744 | Atherosclerotic patients with diabetes mellitus may break through the threshold of healthy TMAO levels formed by long-term statins therapy. | Cardiovascular disease (CVD) is the leading course of disease-related death in both developed and developing countries. Atherosclerosis is main pathology of CVD, and its severity is thought to be related to trimethylamine N-oxide (TMAO) level in plasma. Therefore, it is necessary to deeply understand the synergistic pa... |
36,879,687 | A Case of Metastatic Choriocarcinoma With Intracerebral Hemorrhage Caused by a Ruptured Pseudoaneurysm. | A rare cause of cerebral hemorrhage is the metastasis of choriocarcinoma from gynecology. Herein, we report a case of a patient with brain metastasis of choriocarcinoma with cerebral hemorrhage. A 14-year-old female who had undergone surgery for a hydatidiform molar pregnancy presented with a disturbance of consciousne... |
36,879,558 | Dual-sized hollow particle incorporated fibroin thermal insulating coatings on catheter for cerebral therapeutic hypothermia. | Selective endovascular hypothermia has been used to provide cooling-induced cerebral neuroprotection, but current catheters do not support thermally-insulated transfer of cold infusate, which results in an increased exit temperature, causes hemodilution, and limits its cooling efficiency. Herein, air-sprayed fibroinsil... |
18,287,059 | GeneReviews | Fabry disease is the most common of the lysosomal storage disorders and results from deficient activity of the enzyme alpha-galactosidase A (α-Gal A), leading to progressive lysosomal deposition of globotriaosylceramide and its derivatives in cells throughout the body. The classic form, occurring in males with less tha... |
36,879,557 | TLR4 Enhances Cerebral IschemiaReperfusion Injury via Regulating NLRP3 Inflammasome and Autophagy. | Ischemic stroke is a kind of central nervous disease characterized by high morbidity, high mortality, and high disability. Inflammation and autophagy play important roles in cerebral ischemiareperfusion (CIR) injury. The present study characterizes the effects of TLR4 activation on inflammation and autophagy in CIR inj... |
36,879,362 | Cardiovascular outcomes among patients with castration-resistant prostate cancer A comparative safety study using US administrative claims data. | Cardiovascular conditions are the most prevalent comorbidity among patients with prostate cancer, regardless of treatment. Additionally, cardiovascular risk has been shown to increase following exposure to certain treatments for advanced prostate cancer. There is conflicting evidence on risk of overall and specific car... |
36,879,191 | EPO regulates neuronal differentiation of adult human neural-crest derived stem cells in a sex-specific manner. | Sexual differences in the biology of human stem cells are increasingly recognized to influence their proliferation, differentiation and maturation. Especially in neurodegenerative diseases such as Alzheimers disease (AD), Parkinsons disease (PD) or ischemic stroke, sex is a key player for disease progression and recove... |
36,879,184 | The impact of stroke on the ability to live an independent life at old age a community-based cohort study of Swedish men. | Few studies with controls from the same cohort have investigated the impact of stroke on the ability to live an independent life at old age. We aimed to analyze how great an impact being a stroke survivor would have on cognition and disability. We also analyzed the predictive value of baseline cardiovascular risk facto... |
36,879,127 | Long-term outcomes and quantitative radiologic analysis of extracranial-intracranial bypass for hemodynamically compromised chronic large artery occlusive disease. | This study aimed to demonstrate the effectiveness of nonemergent extracranial-to-intracranial bypass (EIB) in symptomatic chronic large artery atherosclerotic stenosis or occlusive disease (LAA) through quantitative analysis of computed tomography perfusion (CTP) parameters using RAPID software. We retrospectively anal... |
36,878,887 | Creatinine Index A retrospective cohort study in an urban Australian dialysis context. | Maintenance haemodialysis is a catabolic state associated with significant decrease in lean body mass (LBM) and protein energy wasting. LBM can be derived or estimated from creatinine kinetic modelling, specifically the creatinine index (CI). This has been demonstrated in cohort studies predict mortality. 179 patients ... |
36,878,818 | The Validation of Cardiac Index and Stroke-Volume Variation Measured by the Pulse-Wave Transit Time-Analysis Versus Conventional Pulse-Contour Analysis After Off-Pump Coronary Artery Bypass Grafting Observational Study. | To compare the reliability of cardiac index (CI) and stroke-volume variation (SVV) measured by the pulse-wave transit-time (PWTT) method using estimated continuous cardiac output (esCCO) technique with conventional pulse-contour analysis after off-pump coronary artery bypass grafting (OPCAB). A single-center, prospecti... |
36,878,764 | Recommended and observed statin use among U.S. adults - National Health and Nutrition Examination Survey, 2011-2018. | The American College of CardiologyAmerican Heart Association Blood Cholesterol Guideline was published in 2013 (2013 Cholesterol Guideline) and the Multi-society Guideline on the Management of Blood Cholesterol in 2018 (2018 Cholesterol Guideline). To compare differences in population level estimates for statin recomme... |
36,878,722 | Neurologic Improvement in Acute Cerebral Ischemia Frequency, Magnitude, Predictors, and Clinical Outcomes. | Investigations of rapid neurologic improvement (RNI) in patients with acute cerebral ischemia (ACI) have focused on RNI occurring after hospital arrival. However, with stroke routing decisions and interventions increasingly migrating to the prehospital setting, there is a need to delineate the frequency, magnitude, pre... |
36,878,701 | Safety and Efficacy of Tenecteplase and Alteplase in Patients With Tandem Lesion Stroke A Post-Hoc Analysis of the EXTEND-IA TNK Trials. | The safety and efficacy of tenecteplase in patients with tandem lesion stroke is unknown. We performed a comparative analysis of tenecteplase versus alteplase in patients with tandem lesions. We first compared the treatment effect of tenecteplase and alteplase in patients with tandem lesions using individual patient da... |
36,878,689 | Penumbra salvage in extensive stroke exploring limits for reperfusion therapy. | The effect of thrombectomy in patients presenting with extensive ischemic stroke at baseline is currently being investigated it remains uncertain to what extent brain tissue may be saved by reperfusion in such patients. Penumbra salvage volume (PSV) has been described as a tool to measure the volume of rescued penumbra... |
36,878,688 | Development of a clot-adhesive coating to improve the performance of thrombectomy devices. | The first-pass complete recanalization by mechanical thrombectomy (MT) for the treatment of stroke remains limited due to the poor integration of the clot within current devices. Aspiration can help retrieval of the main clot but fails to prevent secondary embolism in the distal arterial territory. The dense meshes of ... |
36,878,687 | CT hyperdense cerebral artery sign reflects distinct proteomic composition in acute ischemic stroke thrombus. | Hyperdense cerebral artery sign (HCAS) is an imaging biomarker in acute ischemic stroke (AIS) that has been shown to be associated with various clinical outcomes and stroke etiology. While prior studies have correlated HCAS with histopathological composition of cerebral thrombus, it is unknown whether and to what exten... |
36,878,673 | Comparative effect of varenicline and nicotine patches on preventing repeat cardiovascular events. | To determine the comparative effectiveness of postdischarge use of varenicline versus prescription nicotine replacement therapy (NRT) patches for the prevention of recurrent cardiovascular events and mortality and whether this association differs by sex. Our cohort study used routinely collected hospital, pharmaceutica... |
36,878,613 | Blood pressure-related white matter microstructural disintegrity and associated cognitive function impairment in asymptomatic adults. | We aimed to investigate the white matter (WM) microstructuralcytostructural disintegrity patterns related to higher systolic blood pressure (SBP), and whether they mediate SBP effects on cognitive performance in middle-aged adults. Using the UK Biobank study of community-dwelling volunteers aged 40-69 years, we include... |
36,878,612 | Loss of life expectancy due to stroke and its subtypes in urban and rural areas in China, 2005-2020. | Stroke is characterised by high mortality and disability rate in China. This study aimed to explore the temporal trends in years of life lost (YLL) and loss of life expectancy due to stroke and its subtypes in urban and rural areas in China during 2005-2020. Data were obtained from China National Mortality Surveillance... |
36,878,404 | Intraoperative hypotension and postoperative stroke in older patients who had brain tumour resections a retrospective cohort analysis. | At some level intraoperative hypotension causes strokes. Elderly neurosurgical patients are presumably at especially high risk. We therefore tested the primary hypothesis that intraoperative hypotension is associated with postoperative stroke in older brain tumour patients. We considered patients more than 65 years old... |
36,878,327 | Constraint-induced movement therapy alleviates motor impairment by inhibiting the accumulation of neutrophil extracellular traps in ischemic cortex. | Stroke is a major cause of mortality and morbidity and most acute strokes are ischemic. Evidence-based medicine has demonstrated the effectiveness of constraint-induced movement therapy (CIMT) in the recovery of motor function in patients after ischemic stroke, but the specific treatment mechanism remains unclear. Here... |
36,878,206 | Cerebellar Superficial Siderosis in Cerebral Amyloid Angiopathy on 1.5T T2-Weighted Imaging. | Cerebellar superficial siderosis (SS) has been recently reported to be present in about 10% of both hereditary and sporadic cerebral amyloid angiopathy (CAA) on 3T MRI using primarily susceptibility-weighted imaging. Our aim was to assess cerebellar SS in sporadic CAA patients using 1.5T T2-weighted MRI and to evaluate... |
36,878,192 | Dantrolene Significantly Improves Cerebral Blood Flow in a Rat Model of Hemorrhagic Vasospasms. | A cerebral vasospasm (CVSP) is a potent vasoconstriction of the cerebral vasculature and the primary cause of morbidity and mortality following a subarachnoid hemorrhage. The middle cerebral artery (MCA) is commonly affected by CVSPs. Concomitant administration of dantrolene and nimodipine synergistically reduces vasos... |
36,878,177 | CANNA-TICS Efficacy and safety of oral treatment with nabiximols in adults with chronic tic disorders - Results of a prospective, multicenter, randomized, double-blind, placebo controlled, phase IIIb superiority study. | Preliminary data suggest that cannabis-based medicines might be a promising new treatment for patients with Tourette syndrome (TS)chronic tic disorders (CTD) resulting in an improvement of tics, comorbidities, and quality of life. This randomized, multicenter, placebo-controlled, phase IIIb study aimed to examine effic... |
36,878,172 | Role of conformational dynamics in pathogenic protein aggregation. | The accumulation of pathogenic protein oligomers and aggregates is associated with several devastating amyloid diseases. As protein aggregation is a multi-step nucleation-dependent process beginning with unfolding or misfolding of the native state, it is important to understand how innate protein dynamics influence agg... |
36,878,154 | Quality assessment of stroke radiomics studies Promoting clinical application. | To evaluate the quality of radiomics studies on stroke using a radiomics quality score (RQS), Minimum Information for Medial AI reporting (MINIMAR) and Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD) to promote clinical application. PubMed MEDLINE and Embase were... |
36,878,125 | SAN-Net Learning generalization to unseen sites for stroke lesion segmentation with self-adaptive normalization. | There are considerable interests in automatic stroke lesion segmentation on magnetic resonance (MR) images in the medical imaging field, as stroke is an important cerebrovascular disease. Although deep learning-based models have been proposed for this task, generalizing these models to unseen sites is difficult due to ... |
36,878,110 | Safety and feasibility of transcranial direct current stimulation stratified by corticospinal organization in children with hemiparesis. | Children with hemiparesis (CWH) due to stroke early in life face lifelong impairments in motor function. Transcranial direct current stimulation (tDCS) may be a safe and feasible adjuvant therapy to augment rehabilitation. Given the variability in outcomes following tDCS, tailored protocols of tDCS are required. We eva... |
36,878,093 | Loureirin C inhibits ferroptosis after cerebral ischemia reperfusion through regulation of the Nrf2 pathway in mice. | Ischemic stroke (IS) is considered as a serious cerebral vascular disease. Ferroptosis is a novel type of regulated cell death (RCD), that closely related to the occurrence and progress of IS. Loureirin C, a type of dihydrochalcone compound derived from the Chinese Dragons blood (CDB). The effective components extracte... |
36,877,853 | Regressive changes in sizes of somatosensory cuneate nucleus after sensory loss in primates. | Neurons in the early stages of processing sensory information suffer transneuronal atrophy when deprived of their activating inputs. For over 40 y, members of our laboratory have studied the reorganization of the somatosensory cortex during and after recovering from different types of sensory loss. Here, we took advant... |
36,877,807 | Treat-to-Target or High-Intensity Statin in Patients With Coronary Artery Disease A Randomized Clinical Trial. | In patients with coronary artery disease, some guidelines recommend initial statin treatment with high-intensity statins to achieve at least a 50% reduction in low-density lipoprotein cholesterol (LDL-C). An alternative approach is to begin with moderate-intensity statins and titrate to a specific LDL-C goal. These alt... |
36,877,792 | Comparison of 3 CT Perfusion Software Packages in Estimation of Ischemic Lesions in Acute Ischemic Stroke Patients. | The aim of this study was to compare 3 computed tomography perfusion (CTP) software packages in the estimation of infarct core volumes, hypoperfusion volumes, and mismatch volumes. Forty-three patients with large vessel occlusion in the anterior circulation who underwent CTP imaging were postprocessed by 3 software pac... |
36,877,597 | Toll-like receptors (TLR2 and TLR4) antagonist mitigates the onset of cerebral small vessel disease through PI3KAktGSK3β pathway in stroke-prone renovascular hypertensive rats. | To examine the effect and mechanism of Toll-Like Receptors (TLR2, TLR4) antagonist in CSVD. The rat model of stroke-induced renovascular hypertension (RHRSP) was constructed. TLR2 and TLR4 antagonist was administrated by Intracranial injection. Morris water maze was used to observe the behavioral changes of rat models.... |
36,877,507 | Limb to Cranial Overflow Dystonia in a Patient After Stroke. | This case report describes noncontiguous overflow dystonia in a patient with diabetes, hypertension, and a history of left putaminal hemorrhage and right hemiparesis. |
36,877,443 | Real-World Racial Variation in Treatment and Outcomes Among Patients with Peripheral Artery Disease. | Prior studies have found considerable disparities in prevalence and outcomes for patients with peripheral arterial disease (PAD). This study compared rates of diagnostic testing, treatment patterns, and outcomes after diagnosis of PAD among commercially insured Black and White patients in the United States. Optums de-i... |
36,877,331 | Secondary Ischemic Stroke Prevention. | The health burden of ischemic stroke is high and will continue to increase with an aging population. Recurrent ischemic stroke is increasingly recognized as a major public health concern with potentially debilitating sequelae. Thus, it is imperative to develop and implement effective strategies for stroke prevention. W... |
36,877,180 | The Lived Experience of Serious Stroke Survival A Hermeneutic Phenomenological Case Study. | The aim of this study was to describe the lived experiences of a serious stroke survivor. This is a hermeneutic phenomenological case study. Data were collected via observations and conversations during 75 visits, 14 brief audiotaped interviews, field notes, and conversations with family members, close friends, and car... |
36,877,177 | Coordinated Care to Optimize Cardiovascular Preventive Therapies in Type 2 Diabetes A Randomized Clinical Trial. | Evidence-based therapies to reduce atherosclerotic cardiovascular disease risk in adults with type 2 diabetes are underused in clinical practice. To assess the effect of a coordinated, multifaceted intervention of assessment, education, and feedback vs usual care on the proportion of adults with type 2 diabetes and ath... |
36,877,129 | Short-term risk of periprocedural stroke relative to radial vs. femoral access systematic review, meta-analysis, study sequential analysis and meta-regression of 2,188,047 real-world cardiac catheterizations. | To verify whether transradial (TRA) compared to transfemoral (TFA) cardiac catheterization reduces the risk of periprocedural stroke (PS). We reviewed (CRD42021277918) published real-world cohorts reporting the incidence of PS within 3 days following diagnostic or interventional catheterization. Meta-analyses and meta-... |
36,876,995 | When is the best time to screen and evaluate for treatable genetic disorders A lifespan perspective. | This paper focuses on the question of, When is the best time to identify an individual at risk for a treatable genetic condition In this review, we describe a framework for considering the optimal timing for pursuing genetic and genomic screening for treatable genetic conditions incorporating a lifespan approach. Utili... |
36,876,965 | Expression of Tie2 (angiopoietin receptor) on the monocyte subpopulations from ischemic stroke patients Histological and flowcytometric studies. | Different subpopulations of monocytes play roles in phagocytosis, inflammation, and angiogenic processes e.g., Tie2-expressing monocytes (TEMs). The brain is flooded with macrophages that are derived from monocytes within 3-7 days after a stroke. This study aimed to determine the expression level of Tie2 (an angiopoiet... |
36,876,946 | Telerehabilitation Initiated Early in Post-Stroke Recovery A Feasibility Study. | Enhanced neural plasticity early after stroke suggests the potential to improve outcomes with intensive rehabilitation therapy. Most patients do not get such therapy, however, due to limited access, changing rehabilitation therapy settings, low therapy doses, and poor compliance. To examine the feasibility, safety, and... |
36,876,740 | Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients. | Bempedoic acid, an ATP citrate lyase inhibitor, reduces low-density lipoprotein (LDL) cholesterol levels and is associated with a low incidence of muscle-related adverse events its effects on cardiovascular outcomes remain uncertain. We conducted a double-blind, randomized, placebo-controlled trial involving patients w... |
36,876,682 | MTHFR C677T polymorphism, homocysteine, burden, and location of AMI and ACI. | We aimed to investigate the relationship between homocysteine levels and MTHFR C677T polymorphisms and acute ischemic vascular events and focused on the differential effects of the MTHFR C677T polymorphisms on the burden and location of AMI and ACI. 102 acute cerebral infarction (ACI) and acute myocardial infarction (A... |
36,876,663 | Correlation research of serum substance P, CCK-8, and 5-HT values with depression levels in stroke survivors. | This study aimed to investigate the correlation of serum octapeptide cholecystokinin-8 (CCK-8), substance P (SP), and 5-hydroxytryptryptamine (5-HT) values with depression levels in patients with post-stroke depression (PSD). It also aimed to explore the potential approach for the early diagnosis of PSD. A correlation ... |
36,876,481 | Optogenetic Spreading Depolarizations Do Not Worsen Acute Ischemic Stroke Outcome. | Spreading depolarizations (SDs) are believed to contribute to injury progression and worsen outcomes in focal cerebral ischemia because exogenously induced SDs have been associated with enlarged infarct volumes. However, previous studies used highly invasive methods to trigger SDs that can directly cause tissue injury ... |
36,876,480 | Change in Smoking Behavior and Outcome After Ischemic Stroke Post-Hoc Analysis of the SPS3 Trial. | Cigarette smoking is a known risk factor for cardiovascular disease, including ischemic stroke. The literature regarding the rate of persistent smoking after acute ischemic stroke and its effect on subsequent cardiovascular events is scarce. With this study, we aimed to report the rate of persistent smoking after ische... |
36,876,365 | Features of gas exchange and metabolism of the brain during revascularization of the carotid arteries. | The relevance of the stated topic of scientific research is determined by the fact that stroke is still the most important medical and social problem both in the world as a whole and in the Republic of Kazakhstan in particular due to high rates of morbidity, mortality, and disability. In addition, cerebrovascular disea... |
36,876,240 | Percutaneous atrial septal defect closure in Ebsteins anomaly. | We report a patient with Ebsteins anomaly, on chronic milrinone therapy for right ventricular failure, who underwent palliative percutaneous closure of her atrial septal defect (ASD) due to recurring strokes. Repeated evaluation of right-sided pressures was performed prior to ASD closure to determine if our patient cou... |
36,876,238 | Improvement in Hypertension Control Among Adults Seen in Federally Qualified Health Center Clinics in the Stroke Belt Implementing a Program with a Dashboard and Process Metrics. | Attain 75% hypertension (HTN) control and improve racial equity in control with the American Medical Association Measure accurately, Act rapidly, Partner with patients blood pressure (AMA MAP BP™) quality improvement program, including a monthly dashboard and practice facilitation. Eight federally qualified health cent... |
36,876,237 | Associations in Cigarette Smoking and Health Conditions by RaceEthnicity Among a Diverse Sample of Patients Receiving Treatment in a Federally Qualified Health Care Setting in Chicago. | To examine the association of cigarette use and smoking-related health conditions by raceethnicity among diverse and low-income patients at a federally qualified health center (FQHC). Demographics, smoking status, health conditions, death, and health service use were extracted from electronic medical data for patients ... |
36,876,182 | Race Analysis and Determination of Stroke Frequency - Stroke Length Combinations during the 50-M Freestyle Event. | The aims of this study were to (1) analyze and compare the stroke kinematics between junior and senior elite male swimmers in every section of the race during the 50-m freestyle event, and (2) identify stroke frequency (SF)-stroke length (SL) combinations on swim speed independently for junior and senior swimmers in ea... |
36,876,051 | Emerging role of miRNAs in the regulation of ferroptosis. | Ferroptosis is a kind of cell death which has distinctive features differentiating it from autophagy, necrosis and apoptosis. This iron-dependent form of cell death is described by an increase in lipid reactive oxygen species, shrinkage of mitochondria and decrease in mitochondrial cristae. Ferroptosis is involved in t... |
36,875,966 | Effect of Postoperative Non-Weight-Bearing in Trochanteric Fracture of the Femur A Retrospective Cohort Study Using Propensity Score Matching. | The effects of postoperative early weight-bearing (WB) on walking ability, muscle mass, and sarcopenia have been investigated. Postoperative WB restriction is also reportedly associated with pneumonia and prolonged hospitalization however, its effect on surgical failures has not been studied. This study aimed to assess... |
36,875,933 | The quality of systematic reviewsmeta-analyses assessing the effects of ankle-foot orthosis on clinical outcomes in stroke patients A methodological systematic review. | Given the importance of systematic reviews (SRs) for practitioners, researchers, and policymakers, it is essential to assess them to ensure robust methodology and reliable results before applying them. The purpose of this methodological study was to assess the methodological and reporting quality of recently published ... |
36,875,853 | Association of a low vitamin D status with risk of post-stroke depression A meta-analysis and systematic review. | Although post-stroke depression (PSD) affects one-third of patients following an acute stroke, pooled evidence addressing the correlation between a low vitamin D status and the risk of PSD remains inconclusive. Comprehensive database search of Medline, EMBASE, Cochrane library, and Google Scholar was performed from inc... |
36,875,818 | The combination of positive anti‑WDR1 antibodies with negative anti‑CFL1 antibodies in serum is a poor prognostic factor for patients with esophageal carcinoma. | WD repeat-containing protein 1 (WDR1) regulates the cofilin 1 (CFL1) activity, promotes cytoskeleton remodeling, and thus, facilitates cell migration and invasion. A previous study reported that autoantibodies against CFL1 and β-actin were useful biomarkers for diagnosing and predicting the prognosis of patients with e... |
36,875,705 | High ratio of C-reactive protein to albumin is associated with hemorrhagic transformation and poor functional outcomes in acute ischemic stroke patients after thrombolysis. | In patients with acute ischemic stroke, hemorrhagic transformation (HT) is a common complication after intravenous thrombolysis (IVT). In this study, we evaluated the relationship between the ratio of C-reactive protein to albumin (CAR) before thrombolysis, HT, and functional outcomes in patients with acute ischemic st... |
36,875,697 | Connectomics underlying motor functional outcomes in the acute period following stroke. | Stroke remains the number one cause of morbidity in many developing countries, and while effective neurorehabilitation strategies exist, it remains difficult to predict the individual trajectories of patients in the acute period, making personalized therapies difficult. Sophisticated and data-driven methods are necessa... |
36,875,689 | Rehabilitation Training Can Significantly Increase the Serum IL-11 Levels and Improve the Prognosis in Ischemic Stroke Patients. | We aimed to explore the expression of IL-11 in ischemic stroke patients and its correlation with rehabilitation training and prognosis. The present randomized control study recruited ischemic stroke patients who were admitted during March 2014 to November 2020. All patients underwent computer tomography (CT) and magnet... |
36,875,673 | Design and implementation of informatization for unified management of stroke rehabilitation in urban multi-level hospitals. | With the aging of the population, the prevalence and incidence of stroke in China are increasing every year. China advocates the establishment of a three-level medical service system for stroke rehabilitation, but it lacks uniform information management among all levels of medical institutions. To achieve unified manag... |
36,875,661 | Brain activation of the PFC during dual-task walking in stroke patients A systematic review and meta-analysis of functional near-infrared spectroscopy studies. | Dual-task walking is a good paradigm to measure the walking ability of stroke patients in daily life. It allows for a better observation of brain activation under dual-task walking to assess the impact of the different tasks on the patient when combining with functional near-infrared spectroscopy (fNIRS). This review a... |
36,875,474 | Oxidative stress in cerebrovascular disease and associated diseases. | Cellular aging is the most severe risk factor for neurodegenerative disease. Simultaneously, oxidative stress (OS) is a critical factor in the aging process, resulting from an imbalance between reactive oxygen and nitrogen species and the antioxidant defense system. Emerging evidence indicates that OS is a common cause... |
36,875,470 | High triglyceride-glucose index is associated with poor cardiovascular outcomes in Chinese acute coronary syndrome patients without diabetes mellitus who underwent emergency percutaneous coronary intervention with drug-eluting stents. | Previous research has supported the association between the triglyceride-glucose index (TyG index) and the incidence and prognosis of cardiovascular disease. However, the association between the TyG index and the prognosis of patients with acute coronary syndrome (ACS) without diabetes mellitus (DM) who underwent emerg... |
36,875,261 | Corrigendum Type 2 diabetes increases risk of unfavorable survival outcome for postoperative ischemic stroke in patients who underwent non-cardiac surgery A retrospective cohort study. | This corrects the article DOI 10.3389fnagi.2021.810050.. |
36,875,230 | Converging theories on dreaming Between Freud, predictive processing, and psychedelic research. | Dreams are still an enigma of human cognition, studied extensively in psychoanalysis and neuroscience. According to the Freudian dream theory and Solms modifications of the unconscious derived from it, the fundamental task of meeting our emotional needs is guided by the principle of homeostasis. Our innate value system... |
36,875,164 | Protocol for the FACE study frailty and comorbidity in elderly patients-a multicenter, Chinese observational cohort study. | The present protocol describes an observational cohort study that was designed to propose a therapeutic scheme and formulate an individualized treatment strategy for frail elderly patients diagnosed with multiple diseases in a Chinese, multicenter setting. Over a 3-year period, we will recruit 30,000 patients from 10 h... |
36,875,114 | Case report Discovery of a | Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) and poikiloderma in association with tendon contractures, myopathy, and pulmonary fibrosis (POIKTMP) are rare inherited syndromes resulting from biallelic pathogenic variants in Through informed consent and enrollment onto IRB-approved protocols (N... |
36,875,044 | Durability is improved by both low and high intensity endurance training. | null |
36,875,009 | Interstage Single Ventricle Heart Disease Infants Show Dysregulation in Multiple Metabolic Pathways Targeted Metabolomics Analysis. | Infants with SVHD experience morbidity related to pulmonary vascular inadequacy. Metabolomic analysis involves a systems biology approach to identifying novel biomarkers and pathways in complex diseases. The metabolome of infants with SVHD is not well understood and no prior study has evaluated the relationship between... |
36,874,760 | Ischemic Stroke Secondary to Myocarditis in the Setting of COVID-19. | Coronavirus disease (COVID-19) is primarily a respiratory disease that has also been shown to be associated with neurological complications such as ischemic stroke, Guillain-Barré syndrome, and encephalitis. Ischemic stroke in patients with COVID-19 has mostly been observed in the elderly, those with significant comorb... |
36,874,751 | Stick a Needle in My Eye A Case Report of Penetrating Needlefish Injury Causing Cavernous Sinus Thrombosis and Carotid Cavernous Fistula. | While swimming in the ocean on vacation in Cuba, a previously healthy 17-year-old female was unexpectedly stabbed through her orbit and into her brain by a needlefish. This is a unique case of a penetrating injury causing orbital cellulitis, retro-orbital abscess, cerebral venous sinus thrombosis and carotid cavernous ... |
36,874,558 | Loss of His-bundle and Right Ventricular Septal Capture Following Transcatheter Aortic Valve Replacement-A Case Report. | Conduction abnormalities following transcatheter aortic valve replacement (TAVR) are common. High-grade atrioventricular block (AVB) and new-onset left bundle branch block remain the most reported. These often require the placement of a permanent pacemaker (PPM). His-bundle (HB) pacing is increasingly being utilized as... |
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