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36,800,717 | Association of Hepcidin levels in Type 2 Diabetes Mellitus treated with metformin or combined anti-diabetic agents in Pakistani population. | To evaluate the impact of hepcidin and ferritin in pathogenesis and prognosis of type 2 diabetes mellitus subjects taking only metformin or combined anti-glycaemic agents. The observational case-control study was conducted at the Department of Physiology, Baqai Medical University, Karachi, from August 2019 to October 2... |
36,800,554 | A National Physician Survey of Deintensifying Diabetes Medications for Older Adults With Type 2 Diabetes. | To determine physicians approach to deintensifying (reducingstopping) or switching hypoglycemia-causing medications for older adults with type 2 diabetes. In this national survey, U.S. physicians in general medicine, geriatrics, or endocrinology reported changes they would make to hypoglycemia-causing medications for o... |
36,800,530 | Gastrointestinal Consequences of Type 2 Diabetes Mellitus and Impaired Glycemic Homeostasis A Mendelian Randomization Study. | We conducted a Mendelian randomization (MR) study to examine the associations of type 2 diabetes and glycemic traits with gastrointestinal diseases (GDs). Uncorrelated genetic variants associated with type 2 diabetes (n 231), fasting insulin (n 38), fasting glucose (n 71), and hemoglobin A1c (n 75) at the genome-wide s... |
36,800,369 | An older diabetes-induced mice model for studying skin wound healing. | Advances in wound treatment depend on the availability of animal models that reflect key aspects of human wound healing physiology. To this date, the accepted mouse models do not reflect defects in the healing process for chronic wounds that are associated with type two diabetic skin ulcers. The long term, systemic phy... |
36,800,286 | GLP-1 Receptor Agonists and Risk of Adverse Cerebrovascular Outcomes in Type 2 Diabetes A Systematic Review and Meta-Analysis of Randomized Controlled Trials. | Effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on ischemichemorhhagic stroke and transient ischemic attacks (TIA) in type-2 diabetes mellitus (T2DM) remains undetermined. To pool effects of GLP-1RAs on adverse cerebrovascular outcomes and investigate impact of baseline variables on these effects. PubMe... |
36,800,181 | Association of Hypertensive Disorders of Pregnancy With Future Cardiovascular Disease. | Hypertensive disorders in pregnancy (HDPs) are major causes of maternal and fetal morbidity and are observationally associated with future maternal risk of cardiovascular disease. However, observational results may be subject to residual confounding and bias. To investigate the association of HDPs with multiple cardiov... |
36,799,940 | Human Epicardial Adipose Tissue Expresses Glucose-dependent Insulinotropic Polypeptide, Glucagon and Glucagon-Like Peptide 1 Receptors as Potential Targets of Pleiotropic Therapies. | Human Epicardial Adipose Tissue (EAT) plays a crucial role in the development and progression of coronary artery disease, atrial fibrillation and heart failure. Microscopically, EAT is composed of adipocytes, nerve tissues, inflammatory, stromovascular and immune cells. EAT is a white adipose tissue, albeit it also has... |
36,799,773 | Feasibility of Exenatide, a GLP-1R Agonist, for Treating Cocaine Use Disorder A Case Series Study. | Cocaine use remains a serious public health problem associated with a marked increase in overdose deaths in the past decade. No medications have yet been proven to be effective for the treatment of cocaine use disorder (CUD). Among the highly promising medications have been glucagon-like peptide 1 receptor agonists (GL... |
36,799,658 | Influence of diabetes mellitus on the biochemical parameters and outcomes of multiple myeloma. | The incidence of MM in most registries remains stable or showing only a slightly increase. However, prevalence of MM is increasing due to the increase in overall survival in the last two decades. The aim of this study was to observe changes in biochemical parameters during the diagnosis and treatment of MM. A retrospec... |
36,799,472 | The fecal microbiotas of women of Pacific and New Zealand European ethnicities are characterized by distinctive enterotypes that reflect dietary intakes and fecal water content. | Obesity is a complex, multifactorial condition that is an important risk factor for noncommunicable diseases including cardiovascular disease and type 2 diabetes. While prevention and management require a healthy and energy balanced diet and adequate physical activity, the taxonomic composition and functional attribute... |
36,799,349 | A Cluster Randomized Controlled Trial Comparing Diabetes Prevention Program Interventions for OverweightObese Marshallese Adults. | This study compared the effectiveness of two Diabetes Prevention Program (DPP) interventions on weight loss among overweight and obese Marshallese adults. The study was a two-arm cluster randomized controlled trial conducted in 30 churches in Arkansas and Oklahoma. Marshallese adults with a body mass index ≥25 kgm |
36,799,324 | Dapagliflozin in DELIVER confirmation of the benefit with SGLT2 inhibitors in heart failure with preserved ejection fraction. | Gliflozins (sodium-glucose cotransporter type 2 inhibitors or SGLT2is) first demonstrated a reduction in hospitalisation for heart failure (hHF) in patients with type 2 diabetes (T2DM) at high cardiovascular risk. Then, a reduction in hHF (also combined with cardiovascular mortality) was reported in patients with heart... |
36,799,298 | Large maternal waist circumference in relation to height is associated with high glucose concentrations in an early-pregnancy oral glucose tolerance test-A population-based study. | To explore the role of maternal anthropometric characteristics in early-pregnancy glycemia, we analyzed the associations and interactions of maternal early-pregnancy waist circumference (WC), height and pre-pregnancy body mass index (BMI) with plasma glucose concentrations in an oral glucose tolerance test (OGTT) at 12... |
36,799,287 | The correlations between steady-state concentration, duration of action and molecular weight of GLP-1RAs and their efficacy and gastrointestinal side effects in patients with type 2 diabetes mellitus A systematic review and meta-analysis. | To assess the influence of steady-state concentration, duration of action and molecular weight of glucagon-like peptide-1 receptor (GLP-1RA) onefficacy and gastrointestinal side effects in patients with type 2 diabetes mellitus (T2DM). PubMed, EMBASE, the Cochrane Center Register of Controlled Trials for Studies and Cl... |
36,799,097 | Functional properties and in vitro starch digestibility of infrared treated (micronized) green banana flour. | The consumption of green banana flour (GBF) products has been linked with reduced glycemic index (GI) and low risk of type 2 diabetes and obesity. The purpose of this study was to investigate the effect of micronization (high-intensity infrared heating method) on the molecular, microstructure and in vitro starch digest... |
36,799,018 | Trajectory of Glycated Hemoglobin Over Time Among Type 2 Diabetes Patients with Obesity on U-100 Basal-Bolus Insulin Regimen Using Real-World Data. | Obesity and complex insulin regimens add treatment challenges for T2DM patients on basal-bolus insulin treatment. A consequence of these challenges can be therapeutic inertia manifested in deteriorating or prolonged poor glycemic control. Identify patient clusters with poor glucose control among T2DM patients with obes... |
36,798,918 | Association of Subclinical Hypothyroidism with Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus A Cross-Sectional Study. | Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are recognized as two common health problems. Metabolic diseases, such as dyslipidemia, obesity, and hypertension are known risk factors for NAFLD. In addition to these risk factors, other risk factors have been recently suggested, such as thy... |
36,798,908 | Correlation Between Mean Amplitude of Glycemic Excursion and Bone Turnover Markers in Patients with Type 2 Diabetes A Cross-Sectional Study. | The present study explores the relationship between glycemic excursion and bone turnover markers. A total of 250 patients with type 2 diabetes mellitus (T2DM) (142 female and 108 male patients) were enrolled in this study. All participants underwent 72 hours of continuous glycemic monitoring to evaluate the mean amplit... |
36,798,871 | Identification and Validation of Immune-Related Genes Diagnostic for Progression of Atherosclerosis and Diabetes. | Atherosclerosis and type 2 diabetes mellitus contribute to a large part of cardiovascular events, but the underlying mechanism remains unclear. In this study, we focused on identifying the linking genes of the diagnostic biomarkers and effective therapeutic targets associated with these two diseases. The transcriptomic... |
36,798,845 | Body composition of type 2 diabetes patients in Uganda A case-control study. | The prevalence of obesity among people diagnosed with Type 2 Diabetes Mellitus (T2DM) has been widely documented. However, the specific composition of this bodyweight remains largely unknown. The study aimed to understand the body composition of T2DM patients using the bioelectric impedance analysis technique, comparin... |
36,798,477 | Protective Effects of Rifampicin and Its Analog Rifampicin Quinone in a Mouse Model of Obesity-Induced Type 2 Diabetes. | Advanced glycation end-products (AGEs) form when glucose reacts non-enzymatically with proteins, leading to abnormal protein function, oxidative stress, and inflammation. AGEs are associated with aging and age-related diseases their formation is aggravated during diabetes. Therefore, drugs preventing AGE formation can ... |
36,798,008 | Assessment of prediabetes knowledge among adults in Al-Madinah, Saudi Arabia. | null |
36,797,835 | COVID-19 and diabetes mellitus a review of the incidence, pathophysiology and management of diabetes during the pandemic. | The COVID-19 pandemic has changed the landscape of modern medicine on a global scale. An emerging concern is the recognition of a bidirectional relationship between COVID-19 and diabetes. Diabetes is a risk factor for severe COVID-19 illness. Intriguingly, recent epidemiological and This review provides an overview of ... |
36,797,785 | Maternal hypertensive disorders during pregnancy and the risk of offspring diabetes mellitus in childhood, adolescence, and early adulthood a nationwide population-based cohort study. | Maternal hypertensive disorders during pregnancy (HDP) have been suggested to contribute to the development of offspring cardiovascular disease later in life, but empirical evidence remains inconsistent. This study was aimed to assess the association of maternal overall and type-specific HDPs with diabetes in offspring... |
36,797,773 | Curalin Supplement for Patients with Type 2 Diabetes Mellitus. | To examine the efficacy and safety of Curalin supplement in patients with type 2 diabetes. Adult patients with type 2 diabetes were randomized 11 to receive Curalin supplement or placebo. The primary endpoint was HbA1c decrease at 1-month. The secondary endpoint was decrease in HbA1c by more than 0.5% and 1%, and chang... |
36,797,706 | Triglyceride-glucose index and triglyceride to high-density lipoprotein cholesterol ratio as potential cardiovascular disease risk factors an analysis of UK biobank data. | The triglyceride-glucose (TyG) index and triglyceride to high-density lipoprotein cholesterol (TGHDL-C) ratio, two simple surrogate indicators of insulin resistance, have been demonstrated to predict cardiovascular disease (CVD). However, very few studies have investigated their associations with CVD in European popula... |
36,797,624 | Effect of Biopsychosocial Factors on Glycemic Control in Type 2 Diabetes Mellitus. | To investigate the effect of diabetic patients biopsychosocial factors on type 2 diabetes mellitus (T2DM) outcomes to contribute to diabetes mellitus management. Cross-sectional descriptive study. Place and Duration of the Study Department of Family Medicine, School of Medicine, Firat University, Turkey, from October 2... |
36,797,616 | Common pathogenetic pathways of Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus. | Type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD) are two cardinal manifestations of the metabolic syndrome, which is becoming a growing global pandemic and a health care burden. They constitute a pathogenetic duo, with complex interplay through interrelated, but still partly understood, pat... |
36,797,025 | Couple-based lifestyle intervention to prevent type 2 diabetes protocol for a randomised pilot trial. | Type 2 diabetes is prevalent among US adults. Lifestyle interventions that modify health behaviours prevent or delay progression to diabetes among individuals at high risk. Despite the well-documented influence of individuals social context on their health, evidence-based type 2 diabetes prevention interventions do not... |
36,796,776 | Type 2 diabetes remission in Australian primary care Protocol for an implementation study of the DiRECT-Aus trial. | Type 2 diabetes is one of the most common chronic conditions managed in Australian general practice. DiRECT-Aus is replicating the UK Diabetes Remission Clinical Trial (DiRECT) in general practices across NSW. The aim of the study will be to explore the implementation of DiRECT-Aus to inform future scale-up and sustain... |
36,796,719 | Treatment with semaglutide, a GLP-1 receptor agonist, improves extracellular matrix remodeling in the pancreatic islet of diet-induced obese mice. | The extracellular matrix (ECM) is fundamental for the normal endocrine functions of pancreatic islet cells and plays key roles in the pathophysiology of type 2 diabetes. Here we investigated the turnover of islet ECM components, including islet amyloid polypeptide (IAPP), in an obese mouse model treated with semaglutid... |
36,796,575 | Elevated remnant cholesterol increase 6-year T2DM onset risk. | To investigate the association of remnant cholesterol (RC) with future type 2 diabetes mellites (T2DM) risk, and to assess the underlying impact of some recognized risk factors on it. A total of 11,468 nondiabetic adults in rural China were recruited in 2007-2008 and followed up in 2013-2014. Logistic regression was us... |
36,796,421 | Post-Load Insulin Secretion Patterns are Associated with Glycemic Status and Diabetic Complications in Patients with Type 2 Diabetes Mellitus. | To examine whether the different patterns of post-load insulin secretion can identify the heterogeneity of type 2 diabetes mellitus (T2DM). Six hundred twenty-five inpatients with T2DM at Jining No. 1 Peoples Hospital were recruited from January 2019 to October 2021. The 140 g steamed bread meal test (SBMT) was conduct... |
36,796,312 | Patterns of new glucagon-like peptide-1 receptor agonist use in patients with type 2 diabetes during 2014-2019 from a US database prescriber and patient characteristics. | null |
36,796,293 | The nature of the binding between insulin receptor and serotonin transporter in placenta (review). | The interplay between the insulin receptor (IR) and serotonin transporter (SERT) allows reciprocal regulation of each others physiological roles to ensure appropriate responses to specific environmental and developmental signals. The studies reported herein provided substantial evidence of how insulin signaling influen... |
36,796,216 | Combined systematic pharmacology and urine metabonomics to study the therapeutic mechanism of type 2 diabetic treated with the herbal pair of Salvia miltiorrhiza Bunge and Pueraria montana var. lobata (Willd.) Sanjappa Pradeep. | The herbal pair of Salvia miltiorrhiza Bunge and Pueraria montana var. lobata (Willd.) Sanjappa Pradeep (DG) is commonly used in the treatment of type 2 diabetes (T2DM) in traditional Chinese medicine (TCM). The drug pair DG was designed by Dr. Zhu chenyu to improve the treatment of T2DM. This study combined with syste... |
36,796,135 | Decreased expression of mitochondrial aminoacyl-tRNA synthetases causes downregulation of OXPHOS subunits in type 2 diabetic muscle. | Type 2 diabetes mellitus (T2D) affects millions of people worldwide and is one of the leading causes of morbidity and mortality. The skeletal muscle (SKM) is one of the most important tissues involved in maintaining glucose homeostasis and substrate oxidation, and it undergoes insulin resistance in T2D. In this study, ... |
36,796,023 | Comprehensive care in type 2 diabetes from DiabeIMSS to CADIMSS. | In diabetes, obtaining optimal control is key to reducing chronic complications. Unfortunately, not all patients achieve the recommended goals. Therefore, the challenges to develop and evaluate comprehensive care models are enormous. In October 2008, the Diabetic Patient Care Program (DiabetIMSS) was designed and imple... |
36,795,707 | Protocol Implementation and evaluation of an adolescent-mediated intervention to improve glycemic control and diabetes self-management among Samoan adults. | Diagnoses of Type 2 Diabetes in the United States have more than doubled in the last two decades. One minority group at disproportionate risk are Pacific Islanders who face numerous barriers to prevention and self-care. To address the need for prevention and treatment in this group, and building on the family-centered ... |
36,795,328 | Association Between Diabetes Severity and Risks of COVID-19 Infection and Outcomes. | Little is known about whether diabetes increases the risk of COVID-19 infection and whether measures of diabetes severity are related to COVID-19 outcomes. Investigate diabetes severity measures as potential risk factors for COVID-19 infection and COVID-19 outcomes. In integrated healthcare systems in Colorado, Oregon,... |
36,795,181 | Exercise-induced microbial changes in preventing type 2 diabetes. | The metabolic benefits associated with long-term physical activity are well appreciated and growing evidence suggests that it involves the gut microbiota. Here we re-evaluated the link between exercise-induced microbial changes and those associated with prediabetes and diabetes. We found that the relative abundances of... |
36,794,003 | High-fiber diet ameliorates gut microbiota, serum metabolism and emotional mood in type 2 diabetes patients. | Previous studies have demonstrated that patients with type 2 diabetes mellitus (T2DM) often had the problems of fecal microbiota dysbiosis, and were usually accompanied with psychiatric comorbidities (such as depression and anxiety). Here, we conducted a randomized clinical study to analyze the changes in gut microbiot... |
36,793,876 | Development process of a clinical guideline to manage type 2 diabetes in adults by Ayurvedic practitioners. | Type 2 diabetes mellitus (T2DM), a common chronic health condition, has major health and socioeconomic consequences. In the Indian subcontinent, it is a health condition for which individuals commonly consult Ayurvedic (traditional medical system) practitioners and use their medicines. However, to date, a good quality ... |
36,793,785 | Studies on alpha-synuclein and islet amyloid polypeptide interaction. | null |
36,793,541 | Regional high iron deposition on quantitative susceptibility mapping correlates with cognitive decline in type 2 diabetes mellitus. | To quantitatively evaluate the iron deposition and volume changes in deep gray nuclei according to threshold-method of quantitative susceptibility mapping (QSM) acquired by strategically acquired gradient echo (STAGE) sequence, and to analyze the correlation between the magnetic susceptibility values (MSV) and cognitiv... |
36,793,528 | Angina Bullosa Hemorrhagica. | Angina bullosa hemorrhagica (ABH) is an underrecognized, benign condition of the oral mucosa. A 26-year-old female patient with type 2 diabetes mellitus presented with sudden-onset painless blood blisters on her soft palate. ABH was clinically diagnosed based on the clinical presentation and spontaneously resolved. Som... |
36,793,475 | Triglyceride-glucose index for the detection of subclinical heart failure with preserved ejection fraction in patients with type 2 diabetes. | The triglyceride-glucose (TyG) index has been identified as a reliable and simple surrogate of insulin resistance. In this study, we sought to determine the association between TyG index and cardiac function among asymptomatic individuals with type 2 diabetes (T2DM) without history of any cardiovascular disease. The cr... |
36,793,285 | Clinical effectiveness of second-line antihyperglycemic drugs on major adverse cardiovascular events An emulation of a target trial. | The cardiovascular benefits of multiple antihyperglycemic drugs as add-on therapies to metformin in the real-practice are unclear. This study aimed to directly compare major adverse cardiovascular events (CVE) associated with these multiple drugs. An emulation of a target trial was conducted using a retrospective-cohor... |
36,793,278 | Factors associated with gastrointestinal side effects after liraglutide treatment for type 2 diabetes. | To identify risk factors predictive of or associated with gastrointestinal side effects (GISE) of liraglutide in patients with type 2 diabetes (T2DM). T2DM patients treated with liraglutide for the first time were obtained and grouped into patients without GSEA and patients with GSEA. Baseline variables, including age,... |
36,793,276 | Evolution of sodium-glucose co-transporter 2 inhibitors from a glucose-lowering drug to a pivotal therapeutic agent for cardio-renal-metabolic syndrome. | Cardio-renal-metabolic (CRM) syndrome, which involves type 2 diabetes mellitus (T2DM), chronic kidney disease (CKD), and heart failure (HF), is a serious healthcare issue globally, with high morbidity and mortality. The disorders that comprise CRM syndrome are independent can mutually affect and accelerate the exacerba... |
36,793,123 | Maturity-onset diabetes of the young secondary to HNF1B variants (HNF1B-MODY) a series of 10 patients from a single diabetes center. | Maturity-Onset Diabetes of the Young (MODY) is an autosomal dominant condition and represents 1-5% of all cases of diabetes mellitus. MODY is often misdiagnosed as type 1 or type 2 diabetes. The rare subtype 5 (HNF1B-MODY) is due to hepatocyte nuclear factor 1β (HNF1B) molecular alteration and is remarkable for its mul... |
36,793,056 | Contraction of human brain vascular pericytes in response to islet amyloid polypeptide is reversed by pramlintide. | The islet amyloid polypeptide (IAPP), a pancreas-produced peptide, has beneficial functions in its monomeric form. However, IAPP aggregates, related to type 2 diabetes mellitus (T2DM), are toxic not only for the pancreas, but also for the brain. In the latter, IAPP is often found in vessels, where it is highly toxic fo... |
36,792,995 | The prevalence of left ventricular hypertrophy associated with type-2 diabetes in Shiraz, Iran a cross-sectional study. | Left ventricular hypertrophy (LVH) is a common diagnosis in patients with cardiovascular disease (CVD). The prevalence of LVH among patients with Type-2 Diabetes Mellitus (T2DM), high blood pressure and aging is higher than the healthy population and has been independently associated with an increased risk for future c... |
36,792,682 | A randomized trial on the effect of transcutaneous electrical nerve stimulator on glycemic control in patients with type 2 diabetes. | Transcutaneous electrical nerve stimulator (TENS) has been demonstrated to be beneficial in glycemic control in animal models, but its application in humans has not been well studied. We randomly assigned 160 patients with type 2 diabetes on oral antidiabetic drugs 11 to the TENS study device (n 81) and placebo (n 79).... |
36,792,668 | Fetal growth restriction followed by early catch-up growth impairs pancreatic islet morphology in male rats. | Fetal growth restriction (FGR), followed by postnatal early catch-up growth, is associated with an increased risk of metabolic dysfunction, including type 2 diabetes in humans. This study aims to determine the effects of FGR and early catch-up growth after birth on the pathogenesis of type 2 diabetes, with particular a... |
36,792,418 | Variants in the Control Region of Mitochondrial Genome Associated with type 2 Diabetes in a Cohort of Mexican Mestizos. | According to the International Diabetes Federation, Mexico is seventh place in the prevalence of type 2 diabetes (T2D) worldwide. Mitochondrial DNA variant association studies in multifactorial diseases like T2D are scarce in Mexican populations. The objective of this study was to analyze the association between 18 var... |
36,792,219 | Pathophysiological significance in abdominal fat distribution in non-obese children with type 2 diabetes. | The aim of the study was to determine the pathogenesis of non-obese children with type 2 diabetes, and its relationship with fat distribution. The study participants included 36 obese children with type 2 diabetes (age 13.5 years, BMI 28.3, BMI percentile 91.9) and 30 non-obese children with type 2 diabetes (age 13.5 y... |
36,792,176 | A questionnaire-based survey of medical conditions in adults with Prader-Willi syndrome in Japan implications for transitional care. | Prader-Willi syndrome (PWS) is a multisystem disorder with increased mortality predominantly due to obesity-associated complications therefore, the management of obesity has been centric to therapeutic strategies for PWS. Although a multidisciplinary team approach has been successful for this purpose during childhood, ... |
36,792,168 | Non-obese or lean non-alcoholic fatty liver disease was associated with increased risk of cancer in patients with type 2 diabetes mellitus. | Risk of non-obese or lean non-alcoholic fatty liver disease (NAFLD) for cancer in patients with type 2 diabetes mellitus (T2DM) is less known. We aimed to evaluate independent associations of NAFLD, especially non-obese or lean NAFLD, and body mass index (BMI) on risks of cancer in patients with T2DM. Cross-sectional a... |
36,791,999 | Oral empagliflozin-loaded tri-layer core-sheath fibers fabricated using tri- axial electrospinning Enhanced in vitro and in vivo antidiabetic performance. | Empagliflozin (EM) was successfully loaded in polycaprolactonepoly (L-lactic acid)polymethyl methacrylate (PCLPLAPMMA) fibers. In the rat β-cell line (BRIN-BD11), the insulin expression ratio of pancreatic β-cells was stimulated at high and low glucose by culturing with tri-layer EM-loaded fiber (EMF) for 48 h. The exp... |
36,791,963 | Comorbidity profile and outcomes in patients with chronic heart failure in a Latin American country Insights from the Colombian heart failure registry (RECOLFACA). | Heart failure (HF) is usually accompanied by cardiovascular and non-cardiovascular comorbidities, which may significantly impact its prognosis. In this study we aimed to characterize the comorbidity profile and its impact in mortality in patients with HF diagnosis from the Colombian Heart Failure Registry (RECOLFACA). ... |
36,791,919 | Dysregulated autophagy A key player in the pathophysiology of type 2 diabetes and its complications. | Autophagy is essential in regulating the turnover of macromolecules via removing damaged organelles, misfolded proteins in various tissues, including liver, skeletal muscles, and adipose tissue to maintain the cellular homeostasis. In these tissues, a specific type of autophagy maintains the accumulation of lipid dropl... |
36,791,875 | Trpc6 knockout improves behavioral dysfunction and reduces Aβ production by inhibiting CN-NFAT1 signaling in T2DM mice. | As the prevalence of diabetes and health awareness increase, type 2 diabetes mellitus -associated cognitive dysfunction is receiving increasing attention. However, the pathogenesis is not entirely understood. Transient receptor potential cation channel 6 (TRPC6) is highly correlated with intracellular Ca |
36,791,634 | Diabetes, Ramadan, and driving - Ensuring patient safety while respecting religious autonomy A qualitative study. | Hypoglycaemia due to fasting during Ramadan may affect the ability to perform complex activities among people with type 2 diabetes mellitus (T2D), but it is unclear how this affects ones ability to drive. This study aims to explore driving experiences and coping strategies to ensure safe driving among people with T2D w... |
36,791,500 | Hepatic oleate regulates one-carbon metabolism during high carbohydrate feeding. | Obesity is a major risk factor for type 2 diabetes, coronary heart disease, and strok. These diseases are associated with profound alterations in gene expression in metabolic tissues. Epigenetic-mediated regulation of gene expression is one mechanism through which environmental factors, such as diet, modify gene expres... |
36,791,135 | Factors predicted quality of life of people with type 2 diabetes in western Ethiopia. | Multiple factors predict the quality of life of adults with diabetes. However, the relationships of demographics, self-management practice, and support status with the quality of life of people with diabetes are unknown. Therefore, the study aimed to assess factors related with the quality of life of adults with type 2... |
36,791,131 | Telemedicine and its acceptance by patients with type 2 diabetes mellitus at a single care center during the COVID-19 emergency A cross-sectional observational study. | When Italy was placed under lockdown to contain the COVID-19 pandemic from 9 March to 18 May 2020, alternative approaches to delivering care-such as telemedicine-were promoted for patients with chronic diseases like diabetes mellitus (DM). The aim of this study was to analyze patients perception of, and satisfaction wi... |
36,791,113 | How chronic conditions are understood, experienced and managed within African communities in Europe, North America and Australia A synthesis of qualitative studies. | This review focuses on the lived experiences of chronic conditions among African communities in the Global North, focusing on established immigrant communities as well as recent immigrant, refugee, and asylum-seeking communities. We conducted a systematic and narrative synthesis of qualitative studies published from in... |
36,790,935 | A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor AlphaGamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition. | A new series of analogues or derivatives of the previously reported PPARαγ dual agonist LT175 allowed the identification of ligand |
36,790,894 | Logistic regression with correlated measurement error and misclassification in covariates. | Many areas of research, such as nutritional epidemiology, may encounter measurement errors of continuous covariates and misclassification of categorical variables when modeling. It is well known that ignoring measurement errors or misclassification can lead to biased results. But most research has focused on solving th... |
36,790,703 | The association between road traffic noise and type 2 diabetes a systematic review and meta-analysis of cohort studies. | The association between road traffic noise and type 2 diabetes (T2DM) was inconsistent. To address this, we have synthesized available cohort studies about their association by meta-analysis. PubMed, Web of Science, EBSCO, Cochrane Library, EMBASE, and Scopus databases were searched up to July 2022. The Quality-effect ... |
36,790,626 | Effect of periodontal therapy on insulin resistance in adults with dysglycemia and periodontitis a systematic review and meta-analysis. | This systematic review and meta-analysis aimed to address whether non-surgical periodontal therapy (NSPT) can affect insulin resistance, estimated by the homeostasis model assessment (HOMA), in adults with prediabetes or type 2 diabetes mellitus and periodontitis. Six electronic databases and the gray literature were s... |
36,790,478 | Skeletal muscle and intermuscular adipose tissue gene expression profiling identifies new biomarkers with prognostic significance for insulin resistance progression and intervention response. | Although insulin resistance often leads to type 2 diabetes mellitus, its early stages are often unrecognised, thus reducing the probability of successful prevention and intervention. Moreover, treatment efficacy is affected by the genetics of the individual. We used gene expression profiles from a cross-sectional study... |
36,790,356 | Network-medicine approach for the identification of genetic association of parathyroid adenoma with cardiovascular disease and type-2 diabetes. | Primary hyperparathyroidism is caused by solitary parathyroid adenomas (PTAs) in most cases (⁓85%), and it has been previously reported that PTAs are associated with cardiovascular disease (CVD) and type-2 diabetes (T2D). To understand the molecular basis of PTAs, we have investigated the genetic association amongst PT... |
36,790,138 | Antenatal dietary supplementation with myo-inositol for preventing gestational diabetes. | Gestational diabetes with onset or first recognition during pregnancy is an increasing problem worldwide. Myo-inositol, an isomer of inositol, is a naturally occurring sugar commonly found in cereals, corn, legumes and meat. Myo-inositol is one of the intracellular mediators of the insulin signal and correlates with in... |
36,789,686 | ox-LDL induces autophagy-mediated apoptosis by suppressing secretagogin-regulated autophagic flux in pancreatic β-cells. | Lipotoxicity has been shown to induce the loss of functional β-cell mass and lead to type 2 diabetes, but the mechanism remains unknown. In this study, we aim to explore the role of secretagogin (SCGN) in lipotoxicity-induced β-cell injury. Our results indicate that ox-LDL treatment leads to autophagic cell death, as e... |
36,789,682 | Once-weekly semaglutide use in patients with type 2 diabetes real-world data from the SURE Italy observational study. | SURE Italy, a multicentre, prospective, open-label, observational, real-world study, investigated once-weekly (OW) semaglutide in patients with type 2 diabetes (T2D) in routine clinical practice. Adults with T2D and ≥1 documented HbA Of 579 patients who initiated semaglutide (FAS), 491 completed the study on treatment ... |
36,789,679 | The effect of type 2 diabetes mellitus on multiple obstructive coronary artery disease. | Although type 2 diabetes mellitus (T2DM) individuals easily develop three-vessel disease (3VD) coronary artery disease (CAD), there is very little information available about their left ventricle (LV) functions. The purpose of this study is to evaluate the LV function using two-dimensional speckle tracking echocardiogr... |
36,789,676 | Nonalcoholic fatty liver disease from a primary care perspective. | Nonalcoholic fatty liver disease (NAFLD) affects up to one-third of the US population. Approximately one-fifth of patients with NAFLD have nonalcoholic steatohepatitis (NASH), characterized by hepatocyte damage and inflammation with or without fibrosis. NASH leads to greater risk of liver-related complications and live... |
36,789,288 | A platform for phenotyping disease progression and associated longitudinal risk factors in large-scale EHRs, with application to incident diabetes complications in the UK Biobank. | Modern healthcare data reflect massive multi-level and multi-scale information collected over many years. The majority of the existing phenotyping algorithms use case-control definitions of disease. This paper aims to study the time to disease onset and progression and identify the time-varying risk factors that drive ... |
36,789,179 | Retracted Effect of Application of Treadmill Training on Metabolic Control and Vitamin D Level in Saudi Patients with Type 2 Diabetes Mellitus. | This retracts the article DOI 10.115520223059629.. |
36,789,109 | Adverse Events Related to Tirzepatide. | Tirzepatide is a dual glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA) approved by the US Food and Drug Administration in May 2022 for patients with type 2 diabetes mellitus (T2DM). We aimed to determine the rates of individual adverse events (AEs) related to 3 stud... |
36,789,054 | Application of inulin in bread A review of technological properties and factors affecting its stability. | Due to its dual function, inulin is an important prebiotic compound in the cereal industry, especially in bread production. In other words, improving technological features and creating health properties (such as reducing the risk of type 2 diabetes, heart disease, metabolic syndrome, and osteoporosis) have led to the ... |
36,789,048 | Ursolic acid enhances the effect of exercise training on vascular aging by reducing oxidative stress in aged type 2 diabetic rats. | Ursolic acid (UA) mediates the vasorelaxant activity via nitric oxide (NO) release, and upregulation of endothelial nitric oxide synthase (eNOS) in endothelial cells (ECs) in disease conditions with increased oxidative stress (OS). The present study aimed to reflect on the impact of 8 weeks of a combination of UA suppl... |
36,789,037 | The effect of acorn muffin consumption on glycemic indices and lipid profile in type 2 diabetic patients A randomized double-blind placebo-controlled clinical trial. | Acorn is a nutritious fruit with the reported potential of ameliorating diseases, including diabetes. This research aimed to assess the effects of acorn muffin consumption on glycemic, lipid indices, and appetite in patients with type 2 diabetes. Sixty-six subjects were dichotomized to receive either one muffin contain... |
36,788,855 | Myocardial Infarction as an Initial Presentation of Essential Thrombocythemia With Calreticulin (CALR) Mutation (None Type 1, None Type 2). | Essential thrombocythemia (ET) is one of the classical Philadelphia-negative myeloproliferative neoplasms with different mutations that can be associated with it, like Janus kinase 2 (JAK2), myeloproliferative leukemia protein (MPL), and Calreticulin (CALR) (types 1 and 2). However, there is a lack in the literature co... |
36,788,551 | Association of four lipid-derived indicators with the risk of developing type 2 diabetes a Chinese population-based cohort study. | Studies have reported that lipid-derived indicators are associated with type 2 diabetes (T2D) in various populations however, it is unclear which lipid-derived indicators could effectively predict T2D risk. Therefore, this study aimed to explore the association between four lipid-derived indicators and T2D risk. This w... |
36,788,521 | Are HOMA-IR and HOMA-B good predictors for diabetes and pre-diabetes subtypes | To investigate the association between the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and Homeostasis Model Assessment of Beta-cell function (HOMA-B) with the incidence of diabetes and pre-diabetes subtypes. A total of 3101 normoglycemic people aged 20-70 years were included in the 6-year follow-up st... |
36,788,517 | The effects of aqueous and ethanolic extracts of Rheum ribes on insulin-resistance and apolipoproteins in patients with type 2 diabetes mellitus a randomized controlled trial. | Previous studies have shown that Rheum ribes (R. ribes) could be effective in controlling the blood glucose levels. This study was conducted to determine the effects of R. ribes supplementation on glycemic indices and apolipoproteins in patients with type 2 diabetes mellitus (T2DM). In the present randomized double-bli... |
36,788,497 | Estimating incidence of type 1 and type 2 diabetes using prevalence data the SEARCH for Diabetes in Youth study. | Incidence is one of the most important epidemiologic indices in surveillance. However, determining incidence is complex and requires time-consuming cohort studies or registries with date of diagnosis. Estimating incidence from prevalence using mathematical relationships may facilitate surveillance efforts. The aim of t... |
36,788,467 | Reproducibility and determinants of the metabolic responses during a mixed-meal tolerance test. | The aim of this study was to assess the reproducibility and physiological determinants of mixed-meal tolerance tests (MMTTs) on glucose and insulin responses. While inpatients on a weight-maintaining diet, 894 individuals (574 with normal and 267 with impaired glucose regulation and 53 with type 2 diabetes T2D) underwe... |
36,787,983 | Glomerular Hyperfiltration Predicts Kidney Function Decline and Mortality in Type 1 and Type 2 Diabetes A 21-Year Longitudinal Study. | To evaluate the prognostic value of glomerular hyperfiltration on long-term kidney-related outcomes and mortality in patients with diabetes. We retrospectively analyzed 21-year longitudinal data from 314 patients with long-standing type 1 or type 2 diabetes. Glomerular hyperfiltration was identified based on the age- a... |
36,787,959 | Plasma Lipidomic n-6 Polyunsaturated Fatty Acids and Type 2 Diabetes Risk in the EPIC-Potsdam Prospective Cohort Study. | Evidence on plasma n-6 polyunsaturated fatty acids (PUFAs) and type 2 diabetes risk is inconsistent. We examined the associations of lipid class-specific PUFA concentrations with type 2 diabetes risk. In the prospective European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort (nested case-coho... |
36,787,958 | Association and Interaction of Genetics and Area-Level Socioeconomic Factors on the Prevalence of Type 2 Diabetes and Obesity. | Quantify the impact of genetic and socioeconomic factors on risk of type 2 diabetes (T2D) and obesity. Among participants in the Mass General Brigham Biobank (MGBB) and UK Biobank (UKB), we used logistic regression models to calculate cross-sectional odds of T2D and obesity using 1) polygenic risk scores for T2D and BM... |
36,787,937 | Effects of Intensive Systolic Blood Pressure Lowering on End-Stage Kidney Disease and Kidney Function Decline in Adults With Type 2 Diabetes Mellitus and Cardiovascular Risk Factors A Post Hoc Analysis of ACCORD-BP and SPRINT. | To determine the effects of intensive systolic blood pressure (SBP) lowering on the risk of major adverse kidney outcomes in people with type 2 diabetes mellitus (T2DM) andor prediabetes and cardiovascular risk factors. This post hoc ACCORD-BP subgroup analysis included participants in the standard glucose-lowering arm... |
36,787,923 | Low-Carbohydrate Diet Scores and Mortality Among Adults With Incident Type 2 Diabetes. | The current study aims to prospectively examine the association between postdiagnosis low-carbohydrate diet (LCD) patterns and mortality among individuals with type 2 diabetes (T2D). Among participants with incident diabetes identified in the Nurses Health Study and Health Professionals Follow-up Study, an overall tota... |
36,787,903 | Safety and Efficacy of the Omnipod 5 Automated Insulin Delivery System in Adults With Type 2 Diabetes From Injections to Hybrid Closed-Loop Therapy. | Automated insulin delivery (AID) has rarely been studied in adults with type 2 diabetes. We tested the feasibility of using AID for type 2 diabetes with the Omnipod 5 System in a multicenter outpatient trial. Participants previously were using either basal-only or basal-bolus insulin injections, with or without the use... |
36,787,895 | Proinsulin-to-C-Peptide Ratio as a Marker of β-Cell Function in African American and European American Adults. | The primary purpose of the current study was to test the hypothesis that the proinsulin-to-C-peptide (PI-to-CP) ratio, as an index of proinsulin secretion, would be higher and associated with indices of β-cell function in African American adults relative to European American adults without type 2 diabetes. Participants... |
36,787,839 | Association of Community Walkability and Glycemic Control Among Pregnant Individuals with Pregestational Diabetes. | Neighborhood walkability is a community-level social determinant of health that measures whether people who live in a neighborhood walk as a mode of transportation. Whether neighborhood walkability is associated with glycemic control among pregnant individuals with pregestational diabetes remains to be defined. To eval... |
36,787,689 | Predicting type 2 diabetes prevalence for people with severe mental illness in a multi-ethnic East London population. | Prevalence of type two diabetes mellitus (T2DM) in people with severe mental illness (SMI) is 2-3 times higher than in general population. Predictive modelling has advanced greatly in the past decade, and it is important to apply cutting-edge methods to vulnerable groups. However, few T2DM prediction models account for... |
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