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56.84154510498047 159 WikiText2 |
19550 Hancock performed it with Arie , Kristina Train and Greg Phillinganes at the 2010 Nobel Peace Prize Concert on 11 December . On 13 February 2011 , the recording — with Pink , Seal , Malian singer Oumou Sangaré , India.Arie and Jeff Beck won a Grammy award for Best Pop Vocal Collaboration . |
168.35997009277344 54 WikiText2 |
19551 The song was performed as part of the closing ceremony of the 2012 Summer Olympics . Performed by the Liverpool Philharmonic Youth Choir and the Liverpool Signing Choir , the choirs sang the first verse and accompanied Lennon 's original vocals during the rest of the song . A cover performed by Emeli Sandé was a... |
43.016780853271484 87 WikiText2 |
19552 In 2015 , American singer / songwriter Lady Gaga performed the song at the 2015 European Games opening ceremony . The song was played for 70 @,@ 000 people in Baku , Azerbaijan that served as host of the event . |
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19553 = = Personnel = = |
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19554 John Lennon – vocals , piano |
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19555 Klaus Voormann – bass |
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19556 Alan White – drums |
2336.580810546875 4 WikiText2 |
19557 The Flux Fiddlers – strings |
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19558 = = Charts and certifications = = |
333.2446594238281 7 WikiText2 |
19559 = = = Documentaries = = = |
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19560 = Big Boy ( song ) = |
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19561 " Big Boy " aka " I 'm A Big Boy Now " was the first single ever recorded by the Jackson 5 , which was released by Steeltown Records in January 1968 . The group played instruments on many of their Steeltown compositions , including " Big Boy " . The song was neither a critical nor commercial success , but the Ja... |
35.610843658447266 72 WikiText2 |
19562 The Jackson 5 would release a second single with Steeltown Records before moving to Motown Records . The group 's recordings at Steeltown Records were thought to be lost , but they were rediscovered more than 25 years later . They were remastered and released in 1995 , with " Big Boy " as the promotional lead si... |
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19563 = = First record deal and lead single = = |
1693.8367919921875 10 WikiText2 |
19564 The Jackson 5 began their career performing at talent contests , which they would often win . During a performance at Beckman Junior High in Gary , Indiana , the group were brought to the attention of Gordon Keith — a singer , record producer , and a founder @-@ owner of Steeltown Records , a company also locate... |
42.14169692993164 253 WikiText2 |
19565 = = Reception and Jackson family = = |
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19566 The Jackson family gathered around a radio to hear the song broadcast for the first time . Michael Jackson — who was 9 years old at the time — said of the experience , " [ the family ] all laughed and hugged one another . We felt we had arrived . " The single " Big Boy " did not appear on any of Billboard 's mus... |
51.90462112426758 81 WikiText2 |
19567 = = Leaving Steeltown = = |
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19568 " The Jackson Five " would release a second and final single through Steeltown Records — " We Don 't Have To Be Over 21 ( to Fall in Love ) " . The two singles were to be supported by an eleven track studio album but it was never released . On July 26 , 1968 , the group signed a contract with Motown Records . Ho... |
36.54865646362305 115 WikiText2 |
19569 = = Rediscovery = = |
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19570 The master tapes to " Big Boy " were thought to be lost , but in 1994 , Jackson family friend Ben Brown found the tapes in his parents ' kitchen pantry . Brown reissued the record in 1995 , on the Inverted Records label — a week before Michael Jackson 's HIStory album was issued . He also remastered the song , s... |
54.658607482910156 203 WikiText2 |
19571 = Chagas disease = |
672.6128540039062 4 WikiText2 |
19572 Chagas disease , also known as American trypanosomiasis , is a tropical parasitic disease caused by the protozoan Trypanosoma cruzi . It is spread mostly by insects known as Triatominae or kissing bugs . The symptoms change over the course of the infection . In the early stage , symptoms are typically either not... |
23.76671600341797 159 WikiText2 |
19573 T. cruzi is commonly spread to humans and other mammals by the blood @-@ sucking " kissing bugs " of the subfamily Triatominae . These insects are known by a number of local names , including : vinchuca in Argentina , Bolivia , Chile and Paraguay , barbeiro ( the barber ) in Brazil , pito in Colombia , chinche i... |
45.096946716308594 134 WikiText2 |
19574 Prevention mostly involves eliminating kissing bugs and avoiding their bites . Other preventative efforts include screening blood used for transfusions . A vaccine has not been developed as of 2013 . Early infections are treatable with the medication benznidazole or nifurtimox . Medication nearly always results ... |
51.08573532104492 111 WikiText2 |
19575 It is estimated that 7 to 8 million people , mostly in Mexico , Central America and South America , have Chagas disease as of 2013 . In 2006 , Chagas was estimated to result in 12 @,@ 500 deaths per year . Most people with the disease are poor , and most people with the disease do not realize they are infected .... |
24.91541862487793 131 WikiText2 |
19576 = = Signs and symptoms = = |
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19577 The human disease occurs in two stages : an acute stage , which occurs shortly after an initial infection , and a chronic stage that develops over many years . |
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19578 The acute phase lasts for the first few weeks or months of infection . It usually occurs unnoticed because it is symptom @-@ free or exhibits only mild symptoms that are not unique to Chagas disease . These can include fever , fatigue , body aches , muscle pain , headache , rash , loss of appetite , diarrhea , n... |
34.607025146484375 99 WikiText2 |
19579 The most recognized marker of acute Chagas disease is called Romaña 's sign , which includes swelling of the eyelids on the side of the face near the bite wound or where the bug feces were deposited or accidentally rubbed into the eye . Rarely , young children , or adults may die from the acute disease due to se... |
47.95760726928711 90 WikiText2 |
19580 If symptoms develop during the acute phase , they usually resolve spontaneously within three to eight weeks in approximately 90 % of individuals . Although the symptoms resolve , even with treatment the infection persists and enters a chronic phase . Of individuals with chronic Chagas disease , 60 – 80 % will ne... |
30.82828140258789 119 WikiText2 |
19581 The symptomatic ( determinate ) chronic stage affects the nervous system , digestive system and heart . About two @-@ thirds of people with chronic symptoms have cardiac damage , including dilated cardiomyopathy , which causes heart rhythm abnormalities and may result in sudden death . About one @-@ third of pat... |
44.26860046386719 103 WikiText2 |
19582 20 % to 50 % of individuals with intestinal involvement also exhibit cardiac involvement . Up to 10 % of chronically infected individuals develop neuritis that results in altered tendon reflexes and sensory impairment . Isolated cases exhibit central nervous system involvement , including dementia , confusion , ... |
59.944435119628906 56 WikiText2 |
19583 The clinical manifestations of Chagas disease are due to cell death in the target tissues that occurs during the infective cycle , by sequentially inducing an inflammatory response , cellular lesions , and fibrosis . For example , intracellular amastigotes destroy the intramural neurons of the autonomic nervous ... |
42.814659118652344 83 WikiText2 |
19584 = = Transmission = = |
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19585 In Chagas @-@ endemic areas , the main mode of transmission is through an insect vector called a triatomine bug . A triatomine becomes infected with T. cruzi by feeding on the blood of an infected person or animal . During the day , triatomines hide in crevices in the walls and roofs . |
45.38527297973633 56 WikiText2 |
19586 The bugs emerge at night , when the inhabitants are sleeping . Because they tend to feed on people 's faces , triatomine bugs are also known as " kissing bugs " . After they bite and ingest blood , they defecate on the person . Triatomines pass T. cruzi parasites ( called trypomastigotes ) in feces left near the... |
65.99695587158203 66 WikiText2 |
19587 Scratching the site of the bite causes the trypomastigotes to enter the host through the wound , or through intact mucous membranes , such as the conjunctiva . Once inside the host , the trypomastigotes invade cells , where they differentiate into intracellular amastigotes . The amastigotes multiply by binary fi... |
29.104631423950195 102 WikiText2 |
19588 Dense vegetation ( such as that of tropical rainforests ) and urban habitats are not ideal for the establishment of the human transmission cycle . However , in regions where the sylvatic habitat and its fauna are thinned by economic exploitation and human habitation , such as in newly deforested areas , piassava... |
50.03642272949219 80 WikiText2 |
19589 T. cruzi can also be transmitted through blood transfusions . With the exception of blood derivatives ( such as fractionated antibodies ) , all blood components are infective . The parasite remains viable at 4 ° C for at least 18 days or up to 250 days when kept at room temperature . It is unclear whether T. cru... |
43.15909194946289 71 WikiText2 |
19590 Other modes of transmission include organ transplantation , through breast milk , and by accidental laboratory exposure . Chagas disease can also be spread congenitally ( from a pregnant woman to her baby ) through the placenta , and accounts for approximately 13 % of stillborn deaths in parts of Brazil . |
45.78456497192383 52 WikiText2 |
19591 Oral transmission is an unusual route of infection , but has been described . In 1991 , farm workers in the state of Paraíba , Brazil , were infected by eating contaminated food ; transmission has also occurred via contaminated açaí palm fruit juice and garapa . A 2007 outbreak in 103 Venezuelan school children ... |
79.74109649658203 62 WikiText2 |
19592 Chagas disease is a growing problem in Europe , because the majority of cases with chronic infection are asymptomatic and because of migration from Latin America . |
41.94084167480469 27 WikiText2 |
19593 = = Diagnosis = = |
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19594 The presence of T. cruzi is diagnostic of Chagas disease . It can be detected by microscopic examination of fresh anticoagulated blood , or its buffy coat , for motile parasites ; or by preparation of thin and thick blood smears stained with Giemsa , for direct visualization of parasites . Microscopically , T. c... |
50.417274475097656 121 WikiText2 |
19595 Various immunoassays for T. cruzi are available and can be used to distinguish among strains ( zymodemes of T.cruzi with divergent pathogenicities ) . These tests include : detecting complement fixation , indirect hemagglutination , indirect fluorescence assays , radioimmunoassays , and ELISA . Alternatively , d... |
45.070072174072266 61 WikiText2 |
19596 = = Prevention = = |
1025.7373046875 5 WikiText2 |
19597 There is currently no vaccine against Chagas disease . Prevention is generally focused on decreasing the numbers of the insect that spreads it ( Triatoma ) and decreasing their contact with humans . This is done by using sprays and paints containing insecticides ( synthetic pyrethroids ) , and improving housing ... |
53.9110107421875 97 WikiText2 |
19598 A yeast trap can be used for monitoring infestations of certain species of triatomine bugs ( Triatoma sordida , Triatoma brasiliensis , Triatoma pseudomaculata , and Panstrongylus megistus ) . |
62.575660705566406 30 WikiText2 |
19599 Promising results were gained with the treatment of vector habitats with the fungus Beauveria bassiana . |
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