id stringlengths 40 40 | title stringlengths 15 120 | text stringlengths 41 3.14k | source stringclasses 2
values |
|---|---|---|---|
c29b5bb77b6cbf19db7bd5dd27f2eff24675aad9 | cyclosporin has now replaced some of the azathioprine | cyclosporin has now replaced some of the azathioprine use due to a longer survival time, especially in heart-related transplantations. moreover, despite being considerably more expensive, mycophenolate mofetil is also increasingly being used in place of azathioprine in organ transplantation, as it is associated with le... | wikipedia |
cfb9903efc3507a991a22a24855f41014bbe8239 | in april 1962, with regimens consisting of azathioprine | in april 1962, with regimens consisting of azathioprine and prednisone, the transplantation of kidneys to unrelated recipients (allotransplantation) was successful for the first time. for many years, this kind of dual therapy with azathioprine and glucocorticoids was the standard antirejection regimen, until cyclospori... | wikipedia |
79ee09fdbe8bd0aae50e76220fb3b79b89701916 | robert schwartz investigated the effect of 6-mp on | robert schwartz investigated the effect of 6-mp on the immune response in 1958 and discovered that it profoundly suppresses the formation of antibodies when given to rabbits together with antigens. following the work done by sir peter medawar and gertrude elion in discovering the immunological basis of rejection of tra... | wikipedia |
e1c7be0426aad44d2d4d98595025cf47ea7d4d34 | azathioprine was synthesized by george herbert hitchings and | azathioprine was synthesized by george herbert hitchings and gertrude elion in 1957 (named bw 57-322) to produce 6-mp in a metabolically active, but masked form, and at first used as a chemotherapy drug. | wikipedia |
7cd03c76786461b0cea4ef2e781f9ab43b0d7a82 | azathioprine is synthesized from 5-chloro-1-methyl-4-nitro-1 h -imidazole and | azathioprine is synthesized from 5-chloro-1-methyl-4-nitro-1 h -imidazole and 6-mercaptopurine in dimethyl sulfoxide. the synthesis of the former starts with an amide from methylamine and diethyl oxalate, which is then cyclized and chlorinated with phosphorus pentachloride; the nitro group is introduced with nitric and... | wikipedia |
7021496bada094c6d7bf63b82dbdbced3964b1dd | azathioprine is a thiopurine linked to a second | azathioprine is a thiopurine linked to a second heterocycle (an imidazole derivative) via a thioether. it is a pale yellow solid with a slightly bitter taste and a melting point of 238–245 °c. it is practically insoluble in water and only slightly soluble in lipophilic solvents such as chloroform, ethanol, and diethyle... | wikipedia |
346aa0147d74585308424dbb27e60b14d8d5f318 | azathioprine is converted within tissues to 6-mp, some | azathioprine is converted within tissues to 6-mp, some of which is converted, in turn, to 6-thioguanine by the addition of an amino group. both 6-mp and 6-thioguanine are conjugated with ribose, and then phosphorylated to form the nucleotides thioinosinic acid and thioguanylic acid, respectively. these nucleotides masq... | wikipedia |
00167f8db90495b0bf4a6556d8ce83f657785749 | azathioprine inhibits purine synthesis. purines are needed to | azathioprine inhibits purine synthesis. purines are needed to produce dna and rna. by inhibiting purine synthesis, less dna and rna are produced for the synthesis of white blood cells, thus causing immunosuppression. | wikipedia |
58767f02e7c56c6abc6c1ca04aaf9aeb0ffa5bd1 | azathioprine is a prodrug, a substance that is | azathioprine is a prodrug, a substance that is not an active drug itself, but is activated in the body. this happens in several steps; at first, it is slowly and almost completely converted to 6-mercaptopurine (6-mp) by reductive cleavage of the thioether (– s –). this is mediated by glutathione and similar compounds i... | wikipedia |
2cb19e534fceaea63caa4d57f3f293e6215c1f50 | azathioprine is absorbed from the gut to about | azathioprine is absorbed from the gut to about 88%. bioavailability varies greatly between individual patients, between 30 and 90%, because the drug is partly inactivated in the liver. highest blood plasma concentrations, counting not only the drug itself, but also its metabolites, are reached after 1–2 hours, and the ... | wikipedia |
81968022a4436bcc8f3fe45a016b164c090bc7d8 | traditionally, as for all cytotoxic drugs, the manufacturer | traditionally, as for all cytotoxic drugs, the manufacturer advises not to breastfeed whilst taking azathioprine, but the "lactation risk category" reported by thomas hale in his book medications and mothers' milk lists azathioprine as "l3", termed "moderately safe". | wikipedia |
958d2e945ea6ac4747330c9cc9ee8efe7866a4a4 | azathioprine can cause birth defects. a 2003 population-based | azathioprine can cause birth defects. a 2003 population-based study in denmark showed that the use of azathioprine and related mercaptopurine resulted in a seven-fold incidence of fetal abnormalities, as well as a 20-fold increase in miscarriage. birth defects in a child whose father was taking azathioprine have also b... | wikipedia |
d16f5504233714ed15e121b901de1b62502ae2c9 | azathioprine decreases the effects of the anticoagulant warfarin | azathioprine decreases the effects of the anticoagulant warfarin and of nondepolarizing muscle relaxants, but increases the effect of depolarizing muscle relaxants. it can also interfere with niacin (vitamin b), resulting in at least one case to pellagra and fatal medullary aplasia. | wikipedia |
2c996625890b6bd751ff71c9115ebe36843300de | other purine analogues, such as allopurinol, inhibit xanthine | other purine analogues, such as allopurinol, inhibit xanthine oxidase, the enzyme that breaks down azathioprine, thus increasing the toxicity of azathioprine. low doses of allopurinol, though, have been shown to safely enhance the efficacy of azathioprine, especially in inflammatory bowel disease nonresponders. this ma... | wikipedia |
8bd38d63d03f5e0ccdf20a0e239540338c3e42ec | large single doses are generally well tolerated; a | large single doses are generally well tolerated; a patient who took 7.5 g azathioprine (150 tablets) at once showed no relevant symptoms apart from vomiting, slightly decreased white blood cell count, and marginal changes in liver function parameters. main symptoms of long-term overdosing are infections of unclear orig... | wikipedia |
83be0ea7d396a5f1fa0805b0ea4b8bfa431b19e6 | in transplant patients, skin cancer is 50 to | in transplant patients, skin cancer is 50 to 250 times more common than in the general population, and between 60 and 90% of patients are affected 20 years after transplantation. the use of immunosuppressive medication including azathioprine in organ transplantation has been linked to increased rates of developing skin... | wikipedia |
69fbda3a5dce777c5c6ca19020da9ebdea8902d3 | cases of hepatosplenic t-cell lymphoma – a rare | cases of hepatosplenic t-cell lymphoma – a rare type of lymphoma – have been reported in patients treated with azathioprine. the majority occurred in patients with inflammatory bowel disease. adolescents and young adult males were the majority of cases. they presented with a very aggressive disease course, and with one... | wikipedia |
9ccf770209b4129ff32b7018bb535253fd8d3f63 | the various diseases requiring transplantation may in themselves | the various diseases requiring transplantation may in themselves increase the risks of non-hodgkin lymphoma, squamous cell carcinomas of the skin, hepatobiliary carcinomas, and mesenchymal tumours to which azathioprine may add additional risks. those receiving azathioprine for rheumatoid arthritis may have a lower risk... | wikipedia |
891f50b19a8783c8e8381e9e0feb40cdc1d4d877 | the risks involved seem to be related both | the risks involved seem to be related both to the duration and the dosage used. people who have previously been treated with an alkylating agent may have an excessive risk of cancers if treated with azathioprine. epidemiological studies by international agency for research on cancer have provided "sufficient" evidence ... | wikipedia |
eca19f632118c2aeb8f54ce66fd78a7c3c451f45 | azathioprine is listed as a human carcinogen in | azathioprine is listed as a human carcinogen in the 12th report on carcinogens by the national toxicology program of u.s. department of health and human services, asserting that it is "known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans." since august 2009, the u.s. fda... | wikipedia |
f99f69df3303f13e67ced53d45b3c8eabc5c07ad | the enzyme thiopurine s-methyltransferase (tpmt) is responsible for | the enzyme thiopurine s-methyltransferase (tpmt) is responsible for various activation and deactivation steps in azathioprine's mechanism of action. the first metabolic step that azathioprine undergoes in the body is the conversion to 6-mercaptopurine (6-mp; see pharmacokinetics), which is itself an immunosuppressant p... | wikipedia |
3a03d8ddf743cf9d8838c5cbfc0e2e27f22d2d6a | nausea and vomiting are common adverse effects, especially | nausea and vomiting are common adverse effects, especially at the beginning of a treatment. such cases are met with taking azathioprine after meals or transient intravenous administration. side effects that are probably hypersensitivity reactions include dizziness, diarrhea, fatigue, and rashes. hair loss is often seen... | wikipedia |
e8033add5948be09d9ddb8124898c67b617f0162 | it was widely used for the treatment of | it was widely used for the treatment of multiple sclerosis until the first half of the 1990s. concerns about increased risk of malignancy has led to a decreased use, yet it is still used in maintenance treatment for people who frequently relapse. a 2007 cochrane review found that azathioprine reduced the number of rela... | wikipedia |
14f7a68353f47f27bdd45fe7cdcd2e21aa470b41 | it is used as an add-on therapy when | it is used as an add-on therapy when steroid therapy is given by mouth for pemphigus and myasthenia gravis, as a "steroid-sparing" agent. azathioprine is also used to maintain remission in people who have granulomatosis with polyangiitis. | wikipedia |
130f8ed7db94c77822105a60b2197282ddf09b32 | azathioprine treatment is associated with an increased risk | azathioprine treatment is associated with an increased risk of lymphoma, but if this is due to the drug or a predisposition related to crohn's disease is unclear. lower doses of azathioprine are used as a therapy in children with refractory or corticosteroid-dependent crohn's disease, without causing many side effects.... | wikipedia |
72777f6726c2d9ea565b14e25903d508c72746c0 | azathioprine has been used in the management of | azathioprine has been used in the management of moderate to severe chronically active crohn's disease, to maintain clinical remission (absence of disease activity) in corticosteroid-dependent patients, and to provide benefit in people with fistulizing crohn's disease. the onset of action is slow, and it may require sev... | wikipedia |
67c56e7917e4d799737c0f1ab378f6b74a3c6117 | being a disease-modifying antirheumatic drug (dmard), azathioprine has | being a disease-modifying antirheumatic drug (dmard), azathioprine has been used for the management of the signs and symptoms of adult rheumatoid arthritis. nonsteroidal anti-inflammatory drugs and corticosteroids may be combined or continued (if they were already in use) with azathioprine, but the combination with oth... | wikipedia |
53eb89ddf4afaf7abec53864cc0b392fc529d455 | azathioprine is used to prevent rejections of kidney | azathioprine is used to prevent rejections of kidney or liver allografts, usually in conjunction with other therapies including corticosteroids, other immunosuppressants, and local radiation therapy. the administration protocol starts either at the time of transplantation or within the following two days. | wikipedia |
7563a8c084044fe602dd920669fb774b2557314c | azathioprine is used alone or in combination with | azathioprine is used alone or in combination with other immunosuppressive therapy to prevent rejection following organ transplantation, and to treat an array of autoimmune diseases, including rheumatoid arthritis, pemphigus, systemic lupus erythematosus, behçet's disease, and other forms of vasculitis, autoimmune hepat... | wikipedia |
194aa2fd9584906a954f46c4f5ac99054e38aa0c | azathioprine was first made in 1957. it is | azathioprine was first made in 1957. it is on the world health organization's list of essential medicines. in 2018, it was the 358th most commonly prescribed medication in the united states, with more than 800,000 prescriptions. | wikipedia |
505238fd54831711a68de76773b3f75e9b85eb09 | common side effects include bone-marrow suppression and vomiting. | common side effects include bone-marrow suppression and vomiting. bone-marrow suppression is especially common in people with a genetic deficiency of the enzyme thiopurine s-methyltransferase. other serious risk factors include an increased risk of certain cancers. use during pregnancy may result in harm to the baby. a... | wikipedia |
4c964ddc681b2144ae013611ff8180d481135d11 | azathioprine, sold under the brand name imuran, among | azathioprine, sold under the brand name imuran, among others, is an immunosuppressive medication. it is used for the treatment of rheumatoid arthritis, granulomatosis with polyangiitis, crohn's disease, ulcerative colitis, and systemic lupus erythematosus; and in kidney transplants to prevent rejection. it is listed by... | wikipedia |
3bf241392040696334afe7f222eafc8a580f142c | guangji bridge, also known as xiangzi bridge, is | guangji bridge, also known as xiangzi bridge, is an ancient bridge that crosses the han river east of chaozhou, guangdong province, china. a key cultural relic under national protection, the bridge is renowned as one of china's four famous ancient bridges, the other three being zhaozhou bridge, lugou bridge, and luoyan... | wikipedia |
b787d473a4ad31308c4af63c26d611c47b422d63 | guangji the monk invited eighteen arhats to help | guangji the monk invited eighteen arhats to help him build the bridge in the west. he went on sanpu mountain to get stones. he changed the stones into cattle and sheep and chased them back. on the way, he met an evil landlord who tried to stop him and get his cattle and sheep. guangji lost some cattle, so part of the b... | wikipedia |
f1a803aad982887b1b48b511f3fbad99546c696e | when han yu, a famous poet in the | when han yu, a famous poet in the history of china, came to chaozhou, he always climbed the bijia mountain (now called han mountain). from the top of the mountain, he saw the river and the difficulty of crossing it, so he asked his nephew han xiangzi and a monk guangji to build a bridge. han xiangzi built the east brid... | wikipedia |
121c8568550ce6c7548cf94b8e9ba405a7ecffce | each pier of guangji bridge has a history | each pier of guangji bridge has a history of several hundred years. from the song dynasty when the first one was built to the year when there were 24, it lasted over 300 years. in ancient times, with their backwardness, it was unimaginable that people could build such a long bridge. therefore, there is a legend that it... | wikipedia |
f53852e8ebebef2220da2699cf8324fd656a6bce | this bridge has the features of a beam | this bridge has the features of a beam bridge, arch bridge, and pontoon bridge, which makes it unique in china. on the bridge, there were various rooms and pavilions, with ox statues on the west and east bridge. people did business on it, so it was also known as "in one li one the bridge, there is one li of business ma... | wikipedia |
140f2840cf9323923e1bee54d2a209634e938b43 | in chaozhou, there is a street called paifang | in chaozhou, there is a street called paifang street. beside this street, there are the many archways of the bridge. one of the chaozhou eight famous scenes is of the rising river of han river (湘桥春涨). every year, the bridge attracts a large number of visitors. the construction of the xiamen-shenzhen railway enabled a g... | wikipedia |
dfec60f05b4a4eed18ee30b40f63a105c42f55f4 | after over 400 years, the pavilions are gone, | after over 400 years, the pavilions are gone, and the ox statue on the east pier washed away by floods. in 1958, a beam bridge supplanted the pontoon bridge. in 1989, another bridge was built to connect the east and west banks, which makes it possible to protect the ancient bridge. in 2009, guangji bridge, having been ... | wikipedia |
1d334399638165a0d35c7a2c3ff7548384001cc3 | in 1724 (the second year of yongzheng (雍正二年), | in 1724 (the second year of yongzheng (雍正二年), zhang ziqian, magistrate of a prefecture, repaired the bridge and had two statues of oxen cast, one for the west bridge and the one for the east, which were meant to protect the bridge. in 1842, the eastern ox statue was lost to a flood. there is a folksong about it, which ... | wikipedia |
0d88b8fef59776b9f97e0418b72b81a355f3c779 | in 1513 (the eighth year of zhengde), another | in 1513 (the eighth year of zhengde), another magistrate of a prefecture, tan lun, added a pier and removed six boats; and the guangji bridge then consisted of 18 boats and 24 piers. people described it as, "eighteen shuttle boats twenty-four continents" (十八梭船二十四洲). | wikipedia |
e83a3218402e2bf43bb9c07e325737aae90d3639 | in the years between the late song dynasty | in the years between the late song dynasty and yuan dynasty, the surrounding area of the bridge was sometimes prosperous and sometimes poor. in 1435 (ming dynasty), a magistrate of a prefecture (知府) named wang yuan had it reconstructed. when it was finished, the west bridge had 10 piers supporting 9 spans and the east ... | wikipedia |
84bb0a6a7248246e3f2f64571e96e3f42fb0d043 | in the year 1174 (chunxi year 淳熙元年间), it | in the year 1174 (chunxi year 淳熙元年间), it was broken up by flooding, so another magistrate, of chang wei prefecture, had workers start to reconstruct it, beginning with bridge piers on the west bank. by 1194, several magistrates of the prefecture—including zhu jiang, wang zhenggong, ding yinyuan, and wang shujin—had bee... | wikipedia |
cbdf7699545e1ef4d5eb77d44b38b47627114524 | there is an old saying, " 到潮不到桥，枉向潮州走一遭 ", | there is an old saying, " 到潮不到桥，枉向潮州走一遭 ", that means if you go to chaozhou without visiting the bridge, you cannot say that you have been to chaozhou. mao yisheng, a famous expert on the bridge, said, "a part of guangji bridge is connected by boats as a pontoon bridge. when it is open, there is a channel for ships and... | wikipedia |
01b3d2d9ccfe2f2b4d310c6826ac83180b82d1ba | guangji bridge (simplified chinese: 广济桥; traditional chinese: 廣濟橋; | guangji bridge (simplified chinese: 广济桥; traditional chinese: 廣濟橋; pinyin: guǎngjì qiáo; lit. ' great charity bridge '), also known as xiangzi bridge (simplified chinese: 湘子桥; traditional chinese: 湘子橋; pinyin: xiāngzǐ qiáo), is an ancient bridge that crosses the han river east of chaozhou, guangdong province, china. a ... | wikipedia |
5b6a5bdf329ea2331fdc2cbfed4b4afcd5ddc149 | onguéné won the 2016 uefa european under-19 championship | onguéné won the 2016 uefa european under-19 championship with france. in august 2018 onguéné switched his allegiance to cameroon and was nominated for the match against comoros in the 2019 africa cup of nations qualification group b. he made his debut for cameroon in a 1–0 win over malawi national football team on 12 o... | wikipedia |
ee404d30d9944cd5bfb71338927733d32f33c220 | on 25 march 2022, onguéné signed a five-year | on 25 march 2022, onguéné signed a five-year contract with eintracht frankfurt in germany, effective 1 july 2022. on 5 january 2023, onguéné returned to red bull salzburg on loan until the end of the season having failed to make an appearance for frankfurt. he did not make any appearances for red bull during this stint... | wikipedia |
500905f9f069179bb4dc9fcd36cbb3b28a5abf85 | on 31 january 2017, onguéné moved to vfb | on 31 january 2017, onguéné moved to vfb stuttgart. he was loaned to fc red bull salzburg on 31 august 2017 until the end of the season. in june 2018 onguéné moved permanently to salzburg. | wikipedia |
aa34f827a790a0b77cf0c5fb8042e5ac15b85d31 | Šatka was listed as an alternate in the | Šatka was listed as an alternate in the senior team for the two qualifying matches against slovenia and england on 1 september 2017. in march 2018, he was called up to the senior team for the first time for two fixtures at the 2018 king's cup. despite being an unused substitute for the 2–1 victory over the united arab ... | wikipedia |
7d389ef8e8fbe2658d46a329d75614ad87f006ef | Šatka agreed to sign for ekstraklasa club lech | Šatka agreed to sign for ekstraklasa club lech poznań on 29 june 2019 on a four-year contract, only joining the club in mid-july after dunajská streda's tie in the 2019–20 uefa europa league first qualifying round. | wikipedia |
6da4cfb1c74e0d4494c6a38c7bb84ee0dbe998c5 | Šatka returned to slovakia to join dunajská streda | Šatka returned to slovakia to join dunajská streda on 10 january 2017 on a six-month loan deal. satka left newcastle when his contract expired at the end of the 2016–17 season. | wikipedia |
1190d0b70c2cd8841e4c632f8599fafe2138b1ed | Šatka joined league two club york city on | Šatka joined league two club york city on 29 january 2016 on a one-month youth loan, and debuted on 6 february as a 58th-minute substitute for matty dixon in a 2–0 away loss to northampton town. | wikipedia |
ffa82a08623c6fb0cf8045a53df3814028a2a78e | Šatka was born in ilava, trenčín region. a | Šatka was born in ilava, trenčín region. a product of dubnica, he joined newcastle united in 2012. in 2014, he was included in the senior squad for a friendly tournament to be held in new zealand. on 3 january 2015, Šatka made his senior debut in an fa cup match against leicester city, which his team lost. | wikipedia |
00a331672980cb09b2bf132cb49db625c328e843 | Ľubomír Šatka (slovak pronunciation:; born 2 december 1995) | Ľubomír Šatka (slovak pronunciation:; born 2 december 1995) is a slovak professional footballer who plays as a centre-back for süper lig club samsunspor and the slovakia national team. | wikipedia |
1d4cfc7fc7b812f12ccaad08462db2bab26753ae | john phillip "jake" fendley was an american basketball | john phillip "jake" fendley was an american basketball player for the fort wayne pistons of the nba. he was drafted with the fourth pick in the third round of the 1951 nba draft. he played two seasons for the pistons, appearing in 103 career games. in his career, jake averaged 2.8 points per game, 1.2 rebounds per game... | wikipedia |
d5ce68d41c9fb5951e9f6542c25f5d57f5c8d285 | john phillip "jake" fendley (june 12, 1929 – | john phillip "jake" fendley (june 12, 1929 – august 9, 2002) was an american basketball player for the fort wayne pistons of the nba. he was drafted with the fourth pick in the third round of the 1951 nba draft. he played two seasons for the pistons, appearing in 103 career games. in his career, jake averaged 2.8 point... | wikipedia |
8a1ee9bf91a1963bef5b405eee349974464025cb | rouché–capelli theorem is a theorem in linear algebra | rouché–capelli theorem is a theorem in linear algebra that determines the number of solutions for a system of linear equations, given the rank of its augmented matrix and coefficient matrix. the theorem is variously known as the: rouché–capelli theorem in english speaking countries, italy and brazil; | wikipedia |
cd134f7afc49bc162b1cdec1140d57a44b75f74f | the rank of a matrice is number of | the rank of a matrice is number of nonzero rows in its reduced row echelon form. if the ranks of the coefficient matrix and the augmented matrix are different, then the last non zero row has the form, {\displaystyle,} corresponding to the equation 0 = 1. otherwise, the i th row of the reduced row echelon form allows ex... | wikipedia |
bb8da67933e3e03db1221b8b90af47f1715e7630 | a system of linear equations with n variables | a system of linear equations with n variables and coefficients in a field k has a solution if and only if its coefficient matrix a and its augmented matrix have the same rank. if there are solutions, they form an affine subspace of k n {\displaystyle k^{n}} of dimension n − rank(a). in particular: | wikipedia |
7a65d5d8a18f93d397e30f41a5871249f47481e0 | the lyman bridge crosses the connecticut river to | the lyman bridge crosses the connecticut river to connect west lebanon, new hampshire, to white river junction, vermont. it is named for elias lyman, who built the original bridge at this location. the current bridge was opened on saturday, october 28, 2017. the lyman bridge carries u.s. route 4 and a pedestrian walkwa... | wikipedia |
d6eba447af322cc18380ac68162d382e204d5ba3 | the lyman bridge crosses the connecticut river to | the lyman bridge crosses the connecticut river to connect west lebanon, new hampshire, to white river junction, vermont. it is named for elias lyman, who built the original bridge at this location. the current bridge was opened on saturday, october 28, 2017. | wikipedia |
a77e0106fb69bb4bc842997bbb6608f9daeae224 | paul roos is a former australian rules football | paul roos is a former australian rules football coach who coached the sydney swans and melbourne football club in the australian football league (afl). as a player, he represented fitzroy and sydney during the 1980s and 1990s. a versatile key-position player, roos was a strong mark who was excellent at ground level, an... | wikipedia |
dbd534a4582585ccd46db5ec287c077c4b71ded1 | in 1992, roos married american native tami hardy, | in 1992, roos married american native tami hardy, a meditation teacher from san diego. they have two sons, dylan and tyler, the latter of whom appeared on the amazing race australia in 2019 and is currently dating american tennis player amanda anisimova. | wikipedia |
a6a8f813f1dbca8edc0cb1d4f07477352a8ed3d8 | the thing that concerns me the most is | the thing that concerns me the most is you can interchange a guy in the third quarter so he comes off, can't come back on again, and you get an injury in the last quarter of the game and you've got a healthy player sitting on the bench doing nothing and an unhealthy player still in your rotations. that really, really c... | wikipedia |
0a0456244d81db2c12a6a5e5baa4ab891fea213a | prior to being appointed as the senior coach | prior to being appointed as the senior coach of the melbourne demons in 2013, roos was reluctant to coach another club after leaving the sydney swans. despite informal inquiries from other clubs like west coast, adelaide, melbourne, gold coast, carlton, and the successor to his old club fitzroy, the brisbane lions, roo... | wikipedia |
c0155208f389cda336c1cef8bd0d906383453a30 | after retiring from coaching at afl level, roos | after retiring from coaching at afl level, roos was appointed head coach of the qbe sydney swans academy, he is the main leader of the academy which has over 300 players. in addition, he had several football-related media roles, including writing for the herald sun and doing match day analysis for fox footy. he also ho... | wikipedia |
e66524eaa67023bbbe4c5ea2b89004e5f1e4bd72 | in the 2015 season, melbourne demons under roos | in the 2015 season, melbourne demons under roos finished in thirteenth place on the ladder with seven wins and fifteen losses. in the 2016 season, melbourne demons under roos finished in eleventh place on the ladder with ten wins and twelve losses. | wikipedia |
48ceaf755cbcac2182bed0bb04a5786766c2628f | he has been accredited for helping the demons | he has been accredited for helping the demons improve their fortunes on the field; the club under roos in his first season as melbourne demons football club senior coach in the 2014 season won four games for the season and eighteen losses, where they finished seventeenth, which is the second-last placed position on the... | wikipedia |
5a52814706b9e8711d11402d5270ecbb2cc36cd5 | on 6 september 2013, roos was appointed senior | on 6 september 2013, roos was appointed senior coach of the melbourne football club on a two-year contract, with the option of a third year. roos replaced melbourne football club caretaker senior coach neil craig, who replaced mark neeld, after neeld was sacked in the middle of the 2013 season. on 28 july 2014, roos si... | wikipedia |
cd8de0683ca881f1b1f2a710c2f4148fa3b7fb1d | roos coached out the 2010 afl season where | roos coached out the 2010 afl season where the sydney swans returned to the finals after last year's absence from the finals. they defeated carlton by five points in its home elimination final but the following week were eliminated by the western bulldogs in the second week of the finals by the same margin. he retired ... | wikipedia |
b24c7557388fc74a59a30de51c72f6c98d4aae54 | the 2009 season, turned out to be roos' | the 2009 season, turned out to be roos' worst ever season at the swans, and the swans' worst season since 1995, when it failed to make the finals, winning only eight games (five of which came in the first nine rounds of the season) and finishing in 12th position. at the end of the 2009 season, roos announced that he wo... | wikipedia |
921781d8ea06606916457b81cfe54cb2f08d83f3 | in early 2008, roos was alleged to have | in early 2008, roos was alleged to have been in the centre of a match-fixing controversy involving wingman jarrad mcveigh. his alleged instructions to mcveigh was to "go forward, just don't kick a goal" during the final stages of the swans' nab cup match against hawthorn, which the swans lost by two points. roos was cl... | wikipedia |
51ce893aa615c55d04075693bea9acfe2cf6f826 | roos also accused carlton of tanking to gain | roos also accused carlton of tanking to gain a third successive priority draft pick when the blues lost its final 11 matches of the regular season, most by lopsided margins (which ultimately led to the sacking of his carlton counterpart denis pagan). this included a 62-point pasting from roos' swans in round 15, the pe... | wikipedia |
8625d42e7c905be70ded347f4aff6196b23b8fc5 | in round 12, 2007, sydney faced collingwood, and | in round 12, 2007, sydney faced collingwood, and lost in a game that roos described as the worst game he had ever coached in his five-year stint at the swans. he responded by dropping star forward barry hall, who had been struggling with injury. | wikipedia |
c36efd6bd974132b1a86a4a61a1cd6f3636b89bd | things became serious when the swans lost at | things became serious when the swans lost at home to the rampant adelaide crows by 39 points, 15.11 (101) to 8.14 (62). roos cited a lack of hunger and even went so far as to say that his team was "clearly incapable of winning the premiership", but the sydney swans under roos managed to reach the 2006 afl grand final a... | wikipedia |
fac6ce8596fa0ca54c9270373c0055309716f864 | roos proved his critics wrong by leading the | roos proved his critics wrong by leading the swans to their first premiership in 72 years, with a hard-fought win against the west coast eagles in the most thrilling grand final for a number of years. many believe that the afl's change of rules for the 2006 season was in direct response to the swans' style of play, but... | wikipedia |
30673b4632769796a6cd651b77200f4dad31a7ae | roos and his swans were criticised for their | roos and his swans were criticised for their game plan in a match against st kilda in mid-2005. this led to the media, led by andrew demetriou and the network ten commentary team, led by stephen quartermain, tim lane and robert walls describing their game plan as "disgusting" and "ugly". the swans misbehaved during the... | wikipedia |
68c1504202f0474761bccd0be791a1d276710213 | in 2005, roos' coaching style was criticised by | in 2005, roos' coaching style was criticised by afl ceo andrew demetriou, who referred to the swans' defensive and negative style of play (presumably the tactics of flooding, and retaining possession through short chip kicks). demetriou even went so far as to claim that the swans would never win a premiership playing s... | wikipedia |
811fbfd80d6dc0bb718f8fdb4661cda5e2928d68 | roos also implemented a policy of giving up | roos also implemented a policy of giving up first round draft picks in exchange for players from other clubs: namely, darren jolly, ted richards, peter everitt, martin mattner, rhyce shaw and shane mumford in the years 2004 – 2009 inclusive. all of whom earned more game-time than they did at their original clubs; this ... | wikipedia |
c77727f9dd91614a5120b5db142207eb142d8242 | under roos' coaching, sydney swans participated in every | under roos' coaching, sydney swans participated in every finals series between 2003 and 2008. they made it to the preliminary final stage in 2003, the semi-final stage in 2004, won the premiership in 2005 and almost retained it in 2006, losing the grand final by only one point, and then got eliminated in the first week... | wikipedia |
f6ba4c6cd119454d68f61f760b291551d1652c3e | as caretaker senior coach, roos immediately transformed the | as caretaker senior coach, roos immediately transformed the dispirited swans players. several who had struggled under eade blossomed under his leadership. surprisingly, the swans won most of their remaining games that year (six of their last ten), and the fans soon let it be known who they wanted as coach by reviving t... | wikipedia |
7aadbdf5802dfb32f5c2c6a962ef063ebfabe360 | returning to australia and the sydney swans, roos | returning to australia and the sydney swans, roos then became an assistant coach under senior coach rodney eade in 2001. part-way through the 2002 season, with the swans' record becoming worse by the week, eade resigned. the club administration started the search for a new coach and it is widely believed that negotiati... | wikipedia |
cd1d90ff56e9a90799b673113bbd4023ffcde4e6 | when his playing career ended, in 1999, roos | when his playing career ended, in 1999, roos moved to the united states, his wife’s homeland, roos then spent some time in the united states and coached the national side to victory over canada. he is often credited as one of the key people in the success of the fledgling united states australian football league, estab... | wikipedia |
431f844bd7a275b9d1d4d882d5b25a564b9b6971 | roos joined sydney swans in 1995 on a | roos joined sydney swans in 1995 on a three-year contract. while roos was at the swans, he was one of sydney's best in the 1996 afl grand final loss to north melbourne. he again qualified as an all-australian in 1996 and 1997. he finished his playing career at the sydney swans with 87 games and 19 goals at the end of 1... | wikipedia |
9114fb6055fed5f2c4dcc048f15dea64e93ea076 | roos left fitzroy at the end of 1994 | roos left fitzroy at the end of 1994 to join the sydney swans. in leaving fitzroy for sydney, roos cited financial difficulty, the departure of key players (such as gary pert to collingwood) and the club's relocation to the western oval as the main reasons for moving to sydney. | wikipedia |
10decb18a6284e4c451e1a871b1fc62f875d37c8 | during his playing career at fitzroy, roos was | during his playing career at fitzroy, roos was selected as an all-australian in 1985, 1987, 1988, 1991 (as captain) and 1992 (as captain). he also represented victoria in state of origin as captain. | wikipedia |
5d562ceb33343451e40cfef40458a60c8662c850 | roos made his senior vfl debut for fitzroy | roos made his senior vfl debut for fitzroy in round 4 of the 1982 season against sydney, the club he would eventually move to 13 years later. also making his debut along with roos was 16-year-old gary pert, who became one of roos' best teammates. in round 9, he was named at full-forward against st kilda and kicked seve... | wikipedia |
8814e1e824ce1c2091bea1dd53be00b655ee6004 | roos grew up in the melbourne suburb of | roos grew up in the melbourne suburb of donvale and played junior football with beverley hills football club in doncaster east. he attended donvale high school from 1975 until 1981. as beverley hills was in fitzroy 's recruiting zone, roos was selected to play for the fitzroy lions in their under 19's team. | wikipedia |
b7afe705c458f2de482f633222c2aa68763384c8 | after finishing as a player, roos went on | after finishing as a player, roos went on to become a successful coach. he was the senior coach of the sydney swans from 2002 to 2010 and guided the swans to the 2005 premiership after they had finished the regular season in 3rd place on the ladder. the swans' previous premiership had been 72 years earlier when they we... | wikipedia |
c605c412d1eda15fba52cfcedd2a3ce9862880a8 | roos was inducted into the australian football hall | roos was inducted into the australian football hall of fame in 2005. he has won many accolades throughout his career: he was named all-australian seven times; received the league's most valuable player (mvp) award; and represented victoria on 14 occasions in state of origin. he is also the afl/vfl record holder for the... | wikipedia |
88f877c99c463f6b0dadb07afde69ae81c9ca36d | a versatile key-position player, roos was a strong | a versatile key-position player, roos was a strong mark who was excellent at ground level, and in his prime was rated the best footballer in australia. he was one of the fitzroy lions' finest players in its final years, and was named at centre half back in fitzroy's team of the century. in his 17 seasons of league foot... | wikipedia |
174f159adc6d66469c8f289000f815fbbdf8c40c | paul roos (born 27 june 1963) is a | paul roos (born 27 june 1963) is a former australian rules football coach who coached the sydney swans and melbourne football club in the australian football league (afl). as a player, he represented fitzroy and sydney during the 1980s and 1990s. | wikipedia |
135f512a90750614c940f00188c19f3dda6d01a3 | in mathematics and economics, transportation theory or transport | in mathematics and economics, transportation theory or transport theory is a name given to the study of optimal transportation and allocation of resources. the problem was formalized by the french mathematician gaspard monge in 1781. in the 1920s a.n. tolstoi was one of the first to study the transportation problem mat... | wikipedia |
e4fbb6475a7f49593e5ec1983604687f78bbc0fe | denoting a {\textstyle a} as the | x | denoting a {\textstyle a} as the | x | × | y | {\textstyle \left\vert \mathbf {x} \right\vert \times \left\vert \mathbf {y} \right\vert } matrix of term a x y = exp (− c x y / ε) {\textstyle a_{xy}=\exp \left(-c_{xy}/\varepsilon \right)}, solving the dual is therefore equivalent to looking for two diagonal positive mat... | wikipedia |
64f7c01eec637c89623246580df05252c5214292 | where, compared with the unregularized version, the "hard" | where, compared with the unregularized version, the "hard" constraint in the former dual (φ x + ψ y − c x y ≥ 0 {\textstyle \varphi _{x}+\psi _{y}-c_{xy}\geq 0}) has been replaced by a "soft" penalization of that constraint (the sum of the ε exp ((φ x + ψ y − c x y) / ε) {\textstyle \varepsilon \exp \left((\varphi _{x}... | wikipedia |
a8d1b0fd4d0a339ffb35eed2ae11730d48ba0351 | for μ {\displaystyle \mu } -almost all x | for μ {\displaystyle \mu } -almost all x ∈ x {\displaystyle x\in x} for some locally lipschitz, c {\displaystyle c} -concave and maximal kantorovich potential φ {\displaystyle \varphi }. (here ∇ φ {\displaystyle \nabla \varphi } denotes the gateaux derivative of φ {\displaystyle \varphi }.) | wikipedia |
1160bda89c7a01ca11b5584817b0a47c741123d8 | let μ ∈ p p r (x) {\displaystyle | let μ ∈ p p r (x) {\displaystyle \mu \in {\mathcal {p}}_{p}^{r}(x)}, ν ∈ p p (x) {\displaystyle \nu \in {\mathcal {p}}_{p}(x)}, c (x, y) = | x − y | p / p {\displaystyle c(x,y)=|x-y|^{p}/p} for p ∈ (1, ∞), p − 1 + q − 1 = 1 {\displaystyle p\in (1,\infty),p^{-1}+q^{-1}=1}. then the kantorovich problem has a unique solut... | wikipedia |
d1184e9a4618d548e5636de976c2b1307e2a5e6f | let x {\displaystyle x} be a separable hilbert | let x {\displaystyle x} be a separable hilbert space. let p p (x) {\displaystyle {\mathcal {p}}_{p}(x)} denote the collection of probability measures on x {\displaystyle x} that have finite p {\displaystyle p} -th moment; let p p r (x) {\displaystyle {\mathcal {p}}_{p}^{r}(x)} denote those elements μ ∈ p p (x) {\displa... | wikipedia |
e0948eb727be50db814c3e7e9fd5eb07275a4c0c | assume the particular case μ = n (0, | assume the particular case μ = n (0, Σ x) {\textstyle \mu ={\mathcal {n}}\left(0,\sigma _{x}\right)}, ν = n (0, Σ y) {\textstyle \nu ={\mathcal {n}}\left(0,\sigma _{y}\right)}, and c (x, y) = | y − a x | 2 / 2 {\textstyle c(x,y)=\left\vert y-ax\right\vert ^{2}/2} where a {\textstyle a} is invertible. one then has | wikipedia |
279856c202801804a4fa31b243989287d85b25fc | in the case when c (x, y) = | in the case when c (x, y) = | x − y | 2 / 2 {\textstyle c\left(x,y\right)=\left\vert x-y\right\vert ^{2}/2}, one can show that the set of x ∈ x {\textstyle x\in \mathbf {x} } assigned to a particular site j {\textstyle j} is a convex polyhedron. the resulting configuration is called a power diagram. | wikipedia |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.