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78be98017a303e10326bb0724715d4796a6819e7
detmers was the first woman to hold a
detmers was the first woman to hold a research position in ohio for the ohio agricultural experiment station, holding it from 1880 to 1892. from 1893 to 1906, she taught science and german in columbus schools, returning to osu in 1906. her 1912 dissertation was a study of buckeye lake's ecology. in 1914, she became ass...
wikipedia
361ba0bf99c182d75f3efc416d41e403abef65a3
detmers was born in dixon, lee county, illinois,
detmers was born in dixon, lee county, illinois, on january 16, 1867, to henry detmers and heimke. her father was the founder of the ohio state university veterinary college. she studied at the university, graduating in 1887 with a b.s. she returned to graduate with an m.s. in 1891.
wikipedia
477ddbb8748550b4b4cacfd45393d3a22ef87ffc
beau mcdonald is a former australian rules footballer
beau mcdonald is a former australian rules footballer in the australian football league. he was recruited as the number 73 draft pick in the 1997 afl draft from swan districts. he made his debut for the brisbane lions in round 4, 1998 against north melbourne. beau mcdonald played 91 senior games for the brisbane lions ...
wikipedia
8c58543f71fa9b99bd93d3cad5e8259b02c8dc5a
beau mcdonald played 91 senior games for the
beau mcdonald played 91 senior games for the brisbane lions including the 2001 and 2002 grand final victories however a string of injuries, a dislocated shoulder in the 2002 afl grand final and an acl knee injury the following year would limit his output to 27 games over the following 5 seasons.
wikipedia
1ca21b91cf03ea6313e4764796c3de0024a18459
bau is the main village on bau island,
bau is the main village on bau island, fiji. once integral to the power and economy of the chiefly village, the villages of lasakau and soso are also located on the twenty-two acre island which became the centre of traditional power throughout the fiji islands in the nineteenth century. because of its historic signific...
wikipedia
9137dfaa8800b99b55bf9d33082cf60384a500cb
bau is the main village on bau island,
meters from the north eastern end of bau off muaidule. today, because of the village's growing population and the restrictive dwelling space on the island, many bauan families live as a community at taro settlement opposite the island on the viti levu coast, next to the main nausori-bau road.
wikipedia
8493d74a91220cf788fb9855bed1817e894dac2c
many bauan villagers since seru epenisa cakobau -
many bauan villagers since seru epenisa cakobau - the leading fijian chief who ceded fiji to the united kingdom - have played significant roles in fiji's history. they include ratu epeli nailatikau, ratu timoci tavanavanua, ratu joni madraiwiwi, ratu sir lala sukuna, ratu penaia kadavulevu, ratu popi seniloli, ratu edw...
wikipedia
e2c1748dc56b0d0827fe55f1aa1f79e8a50fd1f8
the vunivalu's residence named mataiweilagi is situated on
the vunivalu's residence named mataiweilagi is situated on the south east shore front of the village. other chiefly residences that remain in the village are naicobocobo, naisogolaca, muaidule, nadamele, and 'qaranikula'. the district school, the methodist division missionary's residence and the chiefly mausoleum is si...
wikipedia
db05c6d8ff8b8c0e5b5b6c80e5286e6fdf758aa1
during her visit, queen elizabeth conferred on the
during her visit, queen elizabeth conferred on the vunivalu and governor general ratu sir george cakobau a rare and exclusive honour of the royal victorian chain displaying her affection for the high chief of bau and for the people of fiji. the village is the traditional home of the vunivalu tui kaba - the paramount ch...
wikipedia
2f6843f21a4a13fc9381ac82bb829c15d830328b
because of its historic significance, in 1968 the
because of its historic significance, in 1968 the leader of the opposition, a. d. patel proposed setting aside funds to preserve the island. the main historic buildings in the village are the ratu seru cakobau church, the vatanitawake temple and the ulu ni vuaka meeting house situated around the village green or rara. ...
wikipedia
c75177a5c0e1615e719c3ade5d73f3026ace583e
bau (fijian pronunciation:) is the main village on
bau (fijian pronunciation:) is the main village on bau island, fiji. once integral to the power and economy of the chiefly village, the villages of lasakau (traditional fishermen) and soso (traditional carpenters) are also located on the twenty-two acre island which became the centre of traditional power throughout the...
wikipedia
c1ab46ecb76e8b60468748b6a621d925755a56e1
the bo'ai special zone is a restricted zone
the bo'ai special zone is a restricted zone in zhongzheng district, taipei, taiwan, for the protection of the presidential office building. it is in the historic center of taipei and includes other government office buildings and historic sites.
wikipedia
6312d94909d47e41d6deef83025f313bd8ba5364
the zone was claimed jointly by the ministry
the zone was claimed jointly by the ministry of national defense and ministry of the interior according to the national security act to protect the head of state and commander-in-chief. the zone covers of the surrounding area of the presidential office building within distance between 200 and 500 meters. buildings buil...
wikipedia
9172a38d8a900177b8eb1de9cf770268d545e244
the bo'ai special zone is located in the
the bo'ai special zone is located in the historic center of taipei. taipei has been the capital of taiwan since the late-19th century. the japanese constructed the modern government buildings starting in the 1910s; the governor-general of taiwan 's office came first, followed by surrounding government buildings. the cl...
wikipedia
c1ab46ecb76e8b60468748b6a621d925755a56e1
the bo'ai special zone is a restricted zone
the bo'ai special zone is a restricted zone in zhongzheng district, taipei, taiwan, for the protection of the presidential office building. it is in the historic center of taipei and includes other government office buildings and historic sites.
wikipedia
c782692d679002f5d51579fb99bc1d0373a2b7f0
the bloomvale historic district is located east of
the bloomvale historic district is located east of the hamlet of salt point, new york, united states. it is a collection of buildings and structures around the intersection of clinton corners road, state highway ny 82 and the east branch of wappinger creek. most of it is in the town of pleasant valley; the eastern port...
wikipedia
e7f4d03779d74697698c577c4cb4a9470fd95b23
the only surviving workers' home is to the
the only surviving workers' home is to the south of the mill site, on a rise above the road. the former mill manager's house further south is still extant. it has been altered and enlarged and is no longer considered sufficiently historic, so the district boundaries were drawn to exclude it.
wikipedia
f477fbb676ffbf5cadf65e97170438cd8fd0e89e
further east, along the creek, a high table
further east, along the creek, a high table that creates a waterfall marks the site of the 19th-century cotton mill, with a mill pond still behind it. foundation and ground floor wall sections are all that remain of the 45-by-96-foot (14 by 29 m) two-story structure. to the north and east are smaller remains of foundat...
wikipedia
78e1a92f194e1ec97cb1a7cd33b23329483d1363
the 1913 stone cider mill, its 2½-foot–thick (76
the 1913 stone cider mill, its 2½-foot–thick (76 cm) walls built partly with stones from the ruined cotton mill, sits to the south of the creek a short distance east of route 82. it has since been converted into a house. a small shed behind it is the other non-contributing property in the district. to the house's north...
wikipedia
13733d56edc0bdd5bad6ace3232241b97e21aa39
during the 19th century, a kitchen wing was
during the 19th century, a kitchen wing was added to the south and a veranda, since removed, added to the front. two other buildings are amid the five acres (2 ha) of lawns and landscaping on the property, a contributing wellhouse and noncontributing garage. barns that were once on the property no longer exist; one was...
wikipedia
8911290c56906c3c2a0dae6ce3e360102e26afe3
inside the house follows a central hall plan
inside the house follows a central hall plan with large rooms in the front on either side and smaller ones in back that has been minimally altered. most of the interior trim is restrained. doors are paneled on only one side, and the cherry stair rail has no additional finish. the most decorated piece in the house is on...
wikipedia
5efcac5ce63e403312355f00803610656c0906a8
isaac bloom built this five- bay two-story clapboard
isaac bloom built this five- bay two-story clapboard -sided side- gabled federal style mansion in approximately 1801, at the height of his prosperity. its front facade facing northeast, allowing a view of the mill property. exterior decoration includes a palladian window, door sidelights and leaded glass transom. windo...
wikipedia
401ad4b99724a3dd1736cd7e73650baff0114995
swezey may or may not have been successful
swezey may or may not have been successful with his cider mill, but he continued to subdivide and sell portions of the onetime bloom property for the rest of his life. after his death in 1945, his widow sold the mill property and 50 acres (20 ha) to joseph denatale of yonkers. in 1950 the house's veranda was removed; i...
wikipedia
cf0ac4f4b6c4a184dd55da4631f513247ba4d597
in 1919 the bloom mansion, somewhat neglected by
in 1919 the bloom mansion, somewhat neglected by a succession of owners during the previous century save for the addition of a veranda and kitchen wing, received new attention. new owners, and local historians, recognized its historic importance and kept it to better standards as dutchess county began to become a popul...
wikipedia
eed8b1d0d0ebcea8f8b41a19ebde80cd9f237b83
the workers had gradually moved out after the
the workers had gradually moved out after the fire, and the last vestige of bloomvale's industrial prime ended when the chapel stopped holding services in 1910. swezey, who expanded the mill property to 500 acres (200 ha), built a 40-foot (12 m) -square cider mill out of the ruined stones from the cotton mill, with hel...
wikipedia
4397779eb229fbf3b312e90063ec726665242b7f
this period of the mill's history is sketchy.
this period of the mill's history is sketchy. local lore holds that the cotton mill burned down in 1873, but it is difficult to tell from the written record, since all the property transfers from this period refer to the "bloomvale factory." the 1875 sale price, the first one after the date of the fire, is the lowest a...
wikipedia
deca241e8714c9087314fb8f082ae0383ca37538
two years after the census, pond sold the
two years after the census, pond sold the mill to a group of investors from philadelphia for $17,000 ($ 432,000 in contemporary dollars). he had to foreclose on them three years later, in 1875. the property was sold at auction for $3,916 ($ 109,000 in contemporary dollars) to another philadelphia man, henry carson.
wikipedia
2ccf506a10c7196f305a140b5ce81e15703b7ad6
the high purchase price led rosencranz's mortgage, like
the high purchase price led rosencranz's mortgage, like the blooms', into default. in 1862 a man named benjamin pond acquired the property after foreclosure for $2,100 ($ 64,000 in contemporary dollars). rosencranz apparently remained as its manager or in some significant capacity since the 1870 census 's industrial sc...
wikipedia
5102d120db37b5b7023be5b5a1ed2a5a866a689c
the only recorded use of "bloomdale" is on
the only recorded use of "bloomdale" is on the 1856 deed from the hazards' sale of the property to troy industrialist david thomas vail, for $6,000 ($ 203,000 in contemporary dollars). it is possible that it was a misnomer. the deed also suggests that merritt and frost fulfilled the terms of their lease but did not ren...
wikipedia
0d9827dacd932b1ba5ea82b318486781e396f7b7
hazard was unable to industrialize the bloom mill,
hazard was unable to industrialize the bloom mill, since it is still described as a sawmill and gristmill in his 1839 will. his wife and daughters subdivided the farm property, which they continued to live on, and leased the mill to an isaac merritt and charles frost in 1845, on the condition that the two built a cotto...
wikipedia
8bb23a7e09a5abd2da3aea8973241a0497380457
a mortgage the family took out was nevertheless
a mortgage the family took out was nevertheless allowed to default, and in 1826 the blooms lost the properties to a william thurston of new york city. four years later, in 1830, he in turn sold it to rowland hazard of south kingstown, rhode island. his family was already involved in the emerging textile industry, with ...
wikipedia
1e158619d20539e07a9be431147fa7e5093d449d
after isaac bloom's death, his estate was divided
after isaac bloom's death, his estate was divided among his six surviving children and the children of a seventh who had died before him. the complicated and delicate subdivision of his land this entailed required that it be surveyed accurately, and this was done in 1809, adding considerably to the historical record. i...
wikipedia
0d4424de1f3524af315a121b9ce48d4940ddc5e7
bloomvale was his country seat, and he built
bloomvale was his country seat, and he built the large federal style mansion on the southwest corner of the two roads around 1801. it is angled diagonally, to face the mill and the creek. its decoration and size epitomize the highest of the federal style in rural dutchess county of that time. today the building is the ...
wikipedia
6b6b3f4391652728258a42903cbed3a46149f66c
bloom's 1808 obituary records that he was in
bloom's 1808 obituary records that he was in the local militia during the revolutionary war. after independence, he continued to devote himself to public service. he served as the first town clerk after the war, in clinton, of which bloomvale was still part at that time. after service as a county judge, a title he kept...
wikipedia
9aa390f6a31f0ee9a96b27e6ba753ae5c9066b83
the mill continued to be referred to as
the mill continued to be referred to as "filkin's mill" in land records for the rest of the century. sometime around the revolution, though, it became just a name, as isaac filkins sold the mill property to a younger man named isaac bloom, who may have come to dutchess county from what is now brooklyn. the younger man ...
wikipedia
ff0cc247e549ae5753088691a41af2507e2968e6
the first record of a mill at bloomvale
the first record of a mill at bloomvale is a 1749 deed for a nearby tract that describes it as being "west of the kill that isaac filkins grist mill stands on." filkins had inherited the land from his father henry, one of the great nine partners of the area's royal land grant. 11 years earlier, in 1738; it is not known...
wikipedia
7fad1320f8f31e33ba97507e935ea78d19f3cdec
originally built to attract settlement to the region,
originally built to attract settlement to the region, the mill property has passed through three distinct phases of use during its period of historical significance. it remained a gristmill and sawmill, supporting the area's farmers, into the mid-19th century, well after bloom's ownership. redeveloped as an industrial ...
wikipedia
c542f1616a48b6298fe4573471cbb288c4d8c7a4
the area is wooded, with little land cleared
the area is wooded, with little land cleared around the buildings and structures. there are a total of five buildings and eight structures in the district, most of which relate to the area's history as a mill site and date to the 19th century. two of the buildings (a house and modern garage), and one of the structures ...
wikipedia
11f22671b80cadd7d1b96b2212fff67cc03c91d8
the district is an irregularly shaped 38-acre (15
the district is an irregularly shaped 38-acre (15 ha) parcel extending east and west from the junction of route 82 and clinton corners. its boundaries are those of the lots with the contributing properties on them. the creek forms the boundary on the east and southeast.
wikipedia
98dc2cafe030a9ca3a90d713f8ae85137023d7a7
the village (and thus the district) was named
the village (and thus the district) was named after isaac bloom, a landowner and politician in the area during and after the revolutionary war who built a federal style mansion and operated the first mill on the creek (and thus sometimes historically known as bloom ' s mill or bloomdale). by the mid-19th century it had...
wikipedia
647d421a499acab9350aa02a8df4320d0cefcd35
the bloomvale historic district is located east of
the bloomvale historic district is located east of the hamlet of salt point, new york, united states. it is a collection of buildings and structures around the intersection of clinton corners road (dutchess county route 13), state highway ny 82 and the east branch of wappinger creek. most of it is in the town of pleasa...
wikipedia
662ff3a6e58ee6be85c906732fd632942ae16155
glucan endo-1,3-β-d-glucosidase is an enzyme with systematic name
glucan endo-1,3-β-d-glucosidase is an enzyme with systematic name 3-β-d-glucan glucanohydrolase. this enzyme catalyses the following chemical reaction this enzyme is marginally active on mixed-link (1→3,1→4)-β-d-glucans.
wikipedia
0a1a986ab6fa8dc85a6d7507c9ed78e6b913776c
glucan endo-1,3-β- d -glucosidase (ec 3.2.1.39, endo-1,3-β-glucanase, laminarinase,
glucan endo-1,3-β- d -glucosidase (ec 3.2.1.39, endo-1,3-β-glucanase, laminarinase, laminaranase, oligo-1,3-glucosidase, callase, beta-1,3-glucanase, kitalase (trademark), 1,3-β-d-glucan 3-glucanohydrolase, endo-(1,3)-β- d -glucanase, (1→3)-β-glucan 3-glucanohydrolase, endo-1,3-β-d-glucanase, endo-1,3-β-glucosidase, 1,...
wikipedia
a4a7c9dc8a6b5e092c495af9d7de2c6365a314fd
blackbird guitars is a musical instrument company that
blackbird guitars is a musical instrument company that manufactures acoustic guitars and ukuleles from composite materials, including carbon fiber and ekoa, a flax linen reinforcement fabric in a bio-epoxy matrix. the company has made contributions to both the field of luthiery and the field of composite design, notabl...
wikipedia
ea05814046466bb7a3d6a4dccb100b2f896932c2
in 2010, the company released a carbon fiber
in 2010, the company released a carbon fiber ukulele, a tenor size model. in 2011, the company released a carbon fiber oo-sized guitar called the lucky 13. in 2013, the company released a concert size ukulele called the clara, which was the first musical instrument built with ekoa. blackbird has received innovation awa...
wikipedia
61d2d374d18391b1e1842066bffc2fa12a83deb1
the company was founded in 2005 by joe
the company was founded in 2005 by joe luttwak and kyle wolf in san francisco with the intent of producing travel guitars with composite materials, which are more durable than wooden guitars. in 2007, blackbird released its first model, a carbon fiber steel string travel guitar called the rider, which was the first all...
wikipedia
856ada1b225d0e08ca1307e0aabf2591a1c281f4
blackbird guitars is a musical instrument company that
blackbird guitars is a musical instrument company that manufactures acoustic guitars and ukuleles from composite materials, including carbon fiber and ekoa, a flax linen reinforcement fabric in a bio-epoxy matrix. the company has made contributions to both the field of luthiery and the field of composite design, notabl...
wikipedia
76f788249ed8164fdd97d9f64285e3d82c7116a5
ernesto cesàro was an italian mathematician who worked
ernesto cesàro was an italian mathematician who worked in the field of differential geometry. he wrote a book, lezioni di geometria intrinseca, on this topic, in which he also describes fractal, space-filling curves, partly covered by the larger class of de rham curves, but are still known today in his honor as cesàro ...
wikipedia
f78615191e879b546c5bf7c455dd0dab4ff173cc
among his other works are introduction to the
among his other works are introduction to the mathematical theory of infinitesimal calculus (1893), algebraic analysis (1894), elements of infinitesimal calculus (1897). he proposed a possible definition of a limit of divergent sequence, known today as "cesàro's sum," given by the limit of the mean of the sequence part...
wikipedia
a35056f8cd97d9f983ebf00b9ce63209a3613cb6
cesàro's main contributions are in the field of
cesàro's main contributions are in the field of differential geometry. lessons of intrinsic geometry, written in 1894, explains in particular the construction of a fractal curve. after that, cesàro also studied the "snowflake curve" of von koch, continuous but not differentiable in any of its points.
wikipedia
1e0f495fb2ba67c63ad8e191c9b573e2bf69f585
the following year, he obtained a mathematics chair
the following year, he obtained a mathematics chair at the university of palermo, which he kept until 1891. he settled in rome, where he stayed as a professor at the sapienza university until his accidental death, while trying to rescue his youngest son manlio from drowning.
wikipedia
e69e2dbbf05e65b9ea1a224a301f62595bfc52b8
after a rather disappointing start of his academic
after a rather disappointing start of his academic career and a journey through europe - with the most important stop at liège, where his older brother giuseppe raimondo pio cesàro was teaching mineralogy at the local university - ernesto cesàro graduated from the university of rome in 1887, while he was already part o...
wikipedia
086904d920cac06268436380fc26c8db4400139b
ernesto cesàro (12 march 1859 – 12 september
ernesto cesàro (12 march 1859 – 12 september 1906) was an italian mathematician who worked in the field of differential geometry. he wrote a book, lezioni di geometria intrinseca (naples, 1890), on this topic, in which he also describes fractal, space-filling curves, partly covered by the larger class of de rham curves...
wikipedia
f38d6c1d080c61aa8b7f1618710ece09728f26ca
kebebew is a fellow of the american college
kebebew is a fellow of the american college of surgeons, a member of the american thyroid association, american association of endocrine surgeons, and the society of black academic surgeons. kebebew is the goodwill ambassador for the nonprofit ethiopia reads, which promotes children’s literacy.
wikipedia
53b5959901359e8df9727fcd8648e22315e46c22
as of 2020, he has published over 400
as of 2020, he has published over 400 scientific articles, as well as textbooks and chapters, opinion pieces, reviews, and newsletter articles. his focus is on developing effective therapies for fatal, rare, and neglected endocrine cancers, identifying new methods, strategies, and technologies for improving the diagnos...
wikipedia
bac11df38f32ae08722ccc01cb5a91f091db5e35
in 2018, kebebew became the chief of general
in 2018, kebebew became the chief of general surgery and the harry a. oberhelman, jr., and mark l. welton professor of surgery at stanford university. he oversees the entire general surgery division, which includes colorectal surgery, minimally invasive and bariatric surgery, trauma/critical care and acute care surgery...
wikipedia
030ce7ea1d552b3527afd28c7c287480a905f2be
in 2009, kebebew became one of the handful
in 2009, kebebew became one of the handful of african american tenured senior investigators at the national institutes of health (nih) within the national cancer institute (nci). under the leadership of harold e. varmus, kebebew became the inaugural chief of the endocrine oncology surgery branch, overseeing $10 million...
wikipedia
a2caf793f1058939406d179a116f485204eb37d9
he received a t32 nih surgical oncology fellowship
he received a t32 nih surgical oncology fellowship during 1997–1999 and worked in the endocrine oncology laboratory of drs. orlo h. clark and quan-yang duh. after finishing his training in 2002, kebebew became an assistant professor of surgery at ucsf. he established his research and continued to operate on hundreds of...
wikipedia
82333c90ecc11d4951ec6e55a27fe503f5d65988
electron kebebew was born in addis ababa, ethiopia
electron kebebew was born in addis ababa, ethiopia on february 26, 1968. kebebew graduated from the university of california, los angeles in 1991 with a b.s. in chemical engineering. in 1995, he graduated with a medicine degree from the university of california, san francisco where he also went on to do his general sur...
wikipedia
61cc4e5efffa6252a88ab413abd270cd46da2cc5
the gelt bridge or gelt viaduct is a
the gelt bridge or gelt viaduct is a skew arch railway viaduct in the parish of hayton, east of carlisle in cumbria, north west england. built from 1832, it is one of the earliest and largest skew bridges in britain. it is a grade ii* listed building.
wikipedia
e3024e3da0b42c36e7fdfc9b45a04ebfec39f933
the bridge was designed by francis giles, engineer
the bridge was designed by francis giles, engineer to the newcastle & carlisle railway, and built by the contractor, john mckay. construction began in 1832 and the bridge was completed by 1835, making it one of the earliest railway skew bridges and one of the largest of its era. the viaduct is still in use, carrying th...
wikipedia
2e3fc45305c269d3f77a46911b7cb4d9325bd356
the bridge consists of three skew arches, each
the bridge consists of three skew arches, each with a span of 30 feet (9 metres), standing on two rusticated pillars. it carries the railway 60 feet (18 metres) over the river gelt in a deep but narrow gorge. the bridge has a skew angle of 27 degrees. it is built from rusticated red sandstone, with smoothed voussoirs a...
wikipedia
70c4932311d0527aa078767e78594174eb91f85b
giles was the consulting engineer for the entire
giles was the consulting engineer for the entire line but was also directly responsible for the principal works at the western end, which presented some of the greatest engineering challenges on the route, including the gelt bridge and the corby bridge (or wetheral viaduct) and corby viaduct some five miles closer to c...
wikipedia
5b44945febcfdf9da99330414ca1456083cb737d
the idea of linking newcastle upon tyne on
the idea of linking newcastle upon tyne on england's east coast with carlisle on the west dates back to at least the 1770s, when proposals were tabled for a canal. the prospectus for the newcastle & carlisle railway was published in 1825 and construction work began in 1829 under the supervision of francis giles. the li...
wikipedia
8f4f1da3067d6664814217dbe17ab473795ddbeb
the gelt bridge or gelt viaduct (also known
the gelt bridge or gelt viaduct (also known as middle gelt bridge) is a skew arch railway viaduct in the parish of hayton, east of carlisle in cumbria, north west england. built from 1832, it is one of the earliest and largest skew bridges in britain. it is a grade ii* listed building.
wikipedia
92cdd36513fc83cbe0997c80a749460926f3628e
edward thomas ryan is an american microbiologist, immunologist,
edward thomas ryan is an american microbiologist, immunologist, and physician at harvard university and massachusetts general hospital. ryan served as president of the american society of tropical medicine and hygiene from 2009 to 2010. ryan is professor of immunology and infectious diseases at the harvard t.h. chan sc...
wikipedia
8180af3a756e67e8adb631fcd1cac6d291de81a4
ryan has authored or co-authored over 300 publications,
ryan has authored or co-authored over 300 publications, including over 200 in the peer-reviewed literature. he also has served in editorial capacities for plos neglected tropical diseases, the cdc yellow book (health information for international travel), microbes and infections, and is senior editor of hunter’s tropic...
wikipedia
dfc2e429ddd715c3ecb33f6036a5e3b13be8a6e7
ryan teaches at harvard college, harvard medical school
ryan teaches at harvard college, harvard medical school and the harvard school of public health. he trains post-doctoral fellows and students in his laboratory, as well as intern, resident, fellow and student clinicians-in-training at the massachusetts general hospital. he directs a fogarty international center trainin...
wikipedia
2c91ef03a9044a3196f4e16d327c5f45b899491a
ryan is a staff physician and pediatrician at
ryan is a staff physician and pediatrician at the massachusetts general hospital. he is board certified in both internal medicine and infectious diseases, and has expertise in global infectious diseases and tropical medicine, including clinical parasitology, virology, bacteriology and mycology. ryan is the director of ...
wikipedia
01cc4b009baff56579b45d66da9606a1c3faedcb
when the covid-19 pandemic began, ryan pivoted his
when the covid-19 pandemic began, ryan pivoted his focus to working collaboratively on covid-19. efforts included development of an eua (expanded access authorized) laboratory-based pcr test, development of serologic assays for sars-cov-2 (the virus that causes covid-19), analysis of persistence and decay of human anti...
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f99058e649e5b08bf186fceb878f062c6b20a8ce
ryan co-directs the global travepinet (gten) consortium and
ryan co-directs the global travepinet (gten) consortium and program with dr. regina larocque. gten's focus has been to advance the health of u.s. residents who cross international borders. the gten network and its support tools were developed with support from the centers for disease control and prevention with the goa...
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b713a0ef8134aea76bc48c8db06cd2a2b5a29564
ryan's efforts on shigellosis have focused on vaccine
ryan's efforts on shigellosis have focused on vaccine development and host-pathogen interactions. in 2006, ryan showed that administration of antibiotics to children with shigellosis in bangladesh did not increase toxin production by the bacterium. this finding supports targeted antimicrobial treatment of humans with s...
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f09bfd47b2c608bcaf63d24baf1a5d499b6b27b4
ryan's efforts in typhoid have largely focused on
ryan's efforts in typhoid have largely focused on using high throughput analyses to characterize both pathogen responses during typhoid fever, including bacterial gene expression in infected humans, and human immune responses to bacterial infection. this collaborative work with charles and qadri has identified a biomar...
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a45c34694c57f6c6df88db35cbd0672e2c28aa71
together with dr. stephen calderwood, dr. jason harris,
together with dr. stephen calderwood, dr. jason harris, dr. regina larocque, dr. daniel leung, dr. richelle charles and colleagues at harvard, and dr. firdausi qadri and colleagues at the icddrb, ryan has focused on advancing understanding of host-pathogen and immune responses during cholera, a human-restricted infecti...
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821f08aa9fc19c8185d609735883630b01880ce5
ryan was born in new york city and
ryan was born in new york city and educated at the horace mann school. he received his bachelor's degree in biochemical sciences at princeton university. he received a doctorate in medicine from harvard university. he performed medical residency and fellowship training in infectious diseases at the massachusetts genera...
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5264b36a7a6b233906ddedd85f809318483667af
ryan's investigative work has focused on tropical, emerging
ryan's investigative work has focused on tropical, emerging and global infectious diseases, especially understanding host-pathogen interactions, and relating that knowledge to the discovery, development, and implementation of advanced diagnostics and vaccines. particular areas of focus include cholera, typhoid, shigell...
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0653b773f857d3cb4e64d0ebeef03105a629e286
edward thomas ryan (born september 5, 1962) is
edward thomas ryan (born september 5, 1962) is an american microbiologist, immunologist, and physician at harvard university and massachusetts general hospital. ryan served as president of the american society of tropical medicine and hygiene from 2009 to 2010. ryan is professor of immunology and infectious diseases at...
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515ea1d2b3ca6bdec33b6fdd737d0ad61bce2540
the fly pentop computer and fly fusion pentop
the fly pentop computer and fly fusion pentop computer are personal electronics products manufactured by leapfrog enterprises inc. they are called a "pentop" computer by its manufacturer, because they consist of a pen with a computer inside. in 2009, leapfrog discontinued both the manufacture and support of the device ...
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d27bf0792b6e37bdf329de68d1a0eab0aba003a5
fly fusion pentop chips and accessories will not
fly fusion pentop chips and accessories will not work in an original fly 1.0 pentop computer. also, some fly 1.0 products, such as "fly through algebra" contain a chip that will not fit into the fly fusion pentop computer's slot, and cannot be used with the updated fly fusion.
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347f294c4cb1f46e76a967e351d241c8374f3e73
the pen is much smaller and thinner than
the pen is much smaller and thinner than the original fly 1.0 pentop computer. also, it is now a silver color with dark grey accents. the fly fusion can upload and transfer text that was written on paper to a word-processing program, such as microsoft word. mp3 music files can also be downloaded to the pen, allowing it...
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80a4443745f8018e0417fd1dd297fc69deeeabf1
as of 2009, leapfrog had discontinued both versions
as of 2009, leapfrog had discontinued both versions of the fly pentop computer. this also included a halt of all support accessories such as notepads and ink refills which are required for continued use of the pen. the inventor of the fly pentop, jim marggraff, left leapfrog and founded livescribe in january 2007.
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65da26ac10a982d277f2d642cda9a62f22cf1955
the fly fusion pentop computer is the second
the fly fusion pentop computer is the second and last version of the fly 1.0 pentop computer. this pen, like its predecessor, is included with digitized paper that allows the pen's camera (located near to the pen's tip) to "read" what you write. the pen still uses the familiar "flycons" and can play compatible games.
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80dc961a33d0c952a6a25d41d4a48b22602a58d5
many critics of the computer have pointed out
many critics of the computer have pointed out the length of time required for the pen to correctly recognise input from the user. also, some have criticized the lack of a screen, since audio feedback and lights are the only way to get a response from the devices.
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83c996b3f37d52b0fcc3b113a506082bdd8b8f39
activities available for the fly included a spanish
activities available for the fly included a spanish language translator, spelling and mathematical software, and a personal journal. activities for the fly pen came in packs that include a game pad - a different piece of digital paper - or a cartridge. using a game pad begins with the user "downloading" the game from t...
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d7e92edeb79cee41d286873a951e4746225ae199
leapfrog sold several different types of paper with
leapfrog sold several different types of paper with which the pen could be used, often in conjunction with a related programming cartridge. the paper may include special instructions for using the pen, as well as cosmetic alterations to the paper reflecting the subject for which it is intended.
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4351763bc078257a554ecda943b3f4c653f9b3b0
the pen uses digital paper and pattern decoding
the pen uses digital paper and pattern decoding technology developed by anoto to track where the user writes on the page. it uses vision objects' myscript character recognition technology to read what's been written, and can read aloud nearly any word in u.s. english. one notable thing is that the fly uses only capital...
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1fabe74b221fd94f993cbe724847c7da71ae6811
the fly, released in 2005, is a customizable
the fly, released in 2005, is a customizable pen that is intended to assist children with schoolwork. there are several bundled and add-on applications available, including a notepad, calculator, language and writing assistant, and educational games; many of these require the use of a small cartridge that can be insert...
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4a4c9de21762d87e2aa2200a6000140a04f4968e
in 2009, leapfrog discontinued both the manufacture and
in 2009, leapfrog discontinued both the manufacture and support of the device and all accessory products, such as notepads and ink refills which are required for continued use. the inventor of the fly pentop, jim marggraff, left leapfrog and founded livescribe in january 2007.
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cc5828f4be36abf51f682f910339c186e7699001
soon, however, professor sieper's interest was directed towards
soon, however, professor sieper's interest was directed towards the modern period of english literature, and he devoted himself to the study of the aesthetic movement in the romantic and the victorian age. the fruits of his researches in this never forsook the cause he had espoused. in numerous newspaper articles he pl...
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079162e16ce2dde1f2a7c8922de062d83ed0afab
the exponential mechanism is a technique for designing
the exponential mechanism is a technique for designing differentially private algorithms. it was developed by frank mcsherry and kunal talwar in 2007. their work was recognized as a co-winner of the 2009 pet award for outstanding research in privacy enhancing technologies. most of the initial research in the field of d...
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cda736d23b315c2614e5c41e4dc6b10e0163063e
in the above example of the usage of
in the above example of the usage of exponential mechanism, one can output a synthetic dataset in a differentially private manner and can use the dataset to answer queries with good accuracy. other private mechanisms, such as posterior sampling, which returns parameters rather than datasets, can be made equivalent to t...
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50058cec990b63d24fd03384454a8378bf6a8071
b:= {\displaystyle b:=\,\!} the event that the exponential
b:= {\displaystyle b:=\,\!} the event that the exponential mechanism outputs some dataset d ^ {\displaystyle {\widehat {d}}\,\!} such that q (d, d ^) ≤ − α {\displaystyle q(d,{\widehat {d}})\leq -\alpha \,\!}.
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4a59ea4ec2f030c6462ce306bdc0d07cb9a21b43
let a:= {\displaystyle a:=\,\!} the event that the
let a:= {\displaystyle a:=\,\!} the event that the exponential mechanism outputs some dataset d ^ {\displaystyle {\widehat {d}}\,\!} such that q (d, d ^) ≥ − α / 2 {\displaystyle q(d,{\widehat {d}})\geq -\alpha /2\,\!}.
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97b40ef875ce154933699556c1988d1425d5d28b
to show that the mechanism satisfies the (α,
to show that the mechanism satisfies the (α, δ) {\displaystyle (\alpha,\delta)\,\!} -usefulness, we should show that it outputs some dataset d ^ {\displaystyle {\widehat {d}}\,\!} with q (d, d ^) ≥ − α {\displaystyle q(d,{\widehat {d}})\geq -\alpha \,\!} with probability 1 − δ {\displaystyle 1-\delta \,\!}. there are a...
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a78ad62ad5b99e3ce43505987eae1d5405264b11
we define (q (d), q (d ^)) =
we define (q (d), q (d ^)) = − max h ∈ h | q h (d) − q h (d ^) | {\displaystyle (q(d),q({\widehat {d}}))=-\max _{h\in h}|q_{h}(d)-q_{h}({\widehat {d}})|\,\!}.
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f4c9ca602a338b63444a70205516ce9a1866cb9c
definition: for any function q: (({ 0, 1
definition: for any function q: (({ 0, 1 } k) n × ({ 0, 1 } k) m) → r {\displaystyle q:((\{0,1\}^{k})^{n}\times (\{0,1\}^{k})^{m})\rightarrow \mathbb {r} \,\!} and input dataset d {\displaystyle d\,\!}, the exponential mechanism outputs each dataset d ^ {\displaystyle {\widehat {d}}\,\!} with probability proportional t...
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32668c2ba1f03000c5fdcf5a7766a1950fe9c906
where probability is over the distribution of the
where probability is over the distribution of the dataset. thus, if the rhs is less than one then we know for sure that the data set d ^ {\displaystyle {\widehat {d}}\,\!} exists. to bound the rhs to less than one we need m ≥ λ (vcdim (h) log (m / vcdim (h)) / α 2) {\displaystyle m\geq \lambda (\operatorname {vcdim} (h...
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763ed50f29369c65412fd39d143bf181299071ec
lemma: given any dataset d {\displaystyle d\,\!} there
lemma: given any dataset d {\displaystyle d\,\!} there exists a dataset d ^ {\displaystyle {\widehat {d}}\,\!} of size = o (vcdim (h) log (1 / α)) / α 2 {\displaystyle =o(\operatorname {vcdim} (h)\log(1/\alpha))/\alpha ^{2}\,\!} such that max h ∈ h | q h (d) − q h (d ^) | ≤ α / 2 {\displaystyle \max _{h\in h}|q_{h}(d)-...
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e6ccea7ab4a95349182b3df5c1f47c6d638ea08b
one interesting fact is that the algorithm which
one interesting fact is that the algorithm which we are going to develop generates a synthetic dataset whose size is independent of the original dataset; in fact, it only depends on the vc-dimension of the concept class and the parameter α {\displaystyle \alpha \,\!}. the algorithm outputs a dataset of size o ~ (vcdim ...
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2315a10379d9997607e7d6380ce434a88c7b0395
we can output an (α, δ) {\displaystyle (\alpha,\delta)\,\!}
we can output an (α, δ) {\displaystyle (\alpha,\delta)\,\!} -useful dataset d ^ {\displaystyle {\widehat {d}}\,\!} that preserves ε {\displaystyle \varepsilon \,\!} -differential privacy. as we had mentioned earlier the algorithm need not be efficient.
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