IdA string | IdB string | labels int64 | mechanism string | effect string | score float64 | sentence string | signor_id string |
|---|---|---|---|---|---|---|---|
P27361 | Q9UKX7 | 1 | phosphorylation | down-regulates activity | 0.2 | Erk phosphorylates nup50 at ser221 and ser315 phosphorylation of nup50 reduces affinity for importin-beta | SIGNOR-187378 |
Q14289 | P40763 | 1 | phosphorylation | up-regulates activity | 0.428 | These results imply that following EGF stimulation, PYK2 enhances a STAT3-dependent IL8 expression, thus creating a positive feedback loop between ErbB receptors, PYK2, and IL8.|These results suggest that PYK2-induced STAT3 phosphorylation is crucial for IL8 secretion, while IL8 is crucial for EGF-induced MMP9 transcri... | SIGNOR-279429 |
P45984 | P41970 | 1 | phosphorylation | down-regulates activity | 0.323 | JNK binds to the J box in the middle of the protein, and binding is required for phosphorylation of the adjacent EXport motif. Both the binding and phosphorylation sites (the JEX element) are important for Net export. | SIGNOR-250138 |
P16104 | P78527 | 0 | phosphorylation | up-regulates | 0.2 | Dna-dependentprotein_ kinase_ (dna-pk) that phosphorylate h2ax at dsbs | SIGNOR-192443 |
Q13315 | Q9UQ84 | 1 | phosphorylation | up-regulates | 0.83 | The phosphorylation of exo1 by atm appears to regulate the activity of exo1 following resection, allowing optimal rad51 loading and the completion of hr repair. | SIGNOR-162304 |
P17542 | P17612 | 0 | phosphorylation | down-regulates | 0.2 | Thus, our data revealed a novel interplay between pka phosphorylation and tal1-mediated epigenetic regulation that regulates hematopoietic transcription and differentiation programs during hematopoiesis and leukemogenesis. | SIGNOR-195987 |
Q8IUD6 | O95786 | 1 | ubiquitination | up-regulates activity | 0.764 | Our data suggest that Riplet/RNF135 is a novel factor of the RIG-I pathway that is involved in the evoking of human innate immunity against RNA virus infection, and activates RIG-I through ubiquitination of its C-terminal region. | SIGNOR-265569 |
P31751 | P49815 | 1 | phosphorylation | down-regulates | 0.729 | We demonstrate here that tuberin is phosphorylated on s939 and t1462 in response to pi3k activation. Our results are consistent with akt being the pi3k-depen-dent tuberin kinase. The pi3k-akt-mediated phosphorylation of tuberin would inhibit the function of the tuberin-hamartin complex. | SIGNOR-91041 |
P21127 | Q9Y2W1 | 1 | phosphorylation | up-regulates activity | 0.206 | In addition, genetic knockout of CLK1 or chemical inhibition in mice ameliorated diet-induced obesity and insulin resistance at 22\u00b0C. Through proteomics, we uncovered thyroid hormone receptor-associated protein 3 (THRAP3) as an interacting partner of CLK1, further confirmed by co-immunoprecipitation assays.|We fur... | SIGNOR-280209 |
P06493 | O94761 | 1 | phosphorylation | up-regulates activity | 0.355 | During S/G2 phases, CDK1 and CDK2 (CDK1/2) phosphorylate RECQL4 on serines 89 and 251, enhancing MRE11/RECQL4 interaction and RECQL4 recruitment to DSBs. | SIGNOR-277375 |
P01106 | P42771 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.766 | C-myc also directly represses transcription of cdk kinase inhibitors including p27kip1, p21cip1, p15ink4b and p16ink4a | SIGNOR-102743 |
Q38SD2 | P00533 | 0 | phosphorylation | down-regulates activity | 0.343 | In this study, we demonstrate that EGFR regulates the kinase activity of LRRK1 via tyrosine phosphorylation and that this is required for proper endosomal trafficking of EGFR. Phosphorylation of LRRK1 at Tyr-944 results in reduced LRRK1 kinase activity. | SIGNOR-262856 |
P49674 | O15169 | 1 | phosphorylation | up-regulates | 0.747 | We conclude that a major role of axin in the wnt is to provide the kinase activity that initiates the betBeta-catenin phosphorylation cascade at s45. This process is mediated by cki, the alfa, delta, or ? Isoform, all detected in association with axin by lc/ms. | SIGNOR-87444 |
P31749 | O43524 | 1 | phosphorylation | down-regulates activity | 0.91 | Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14?3?3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function | SIGNOR-252523 |
P25054 | P17612 | 0 | phosphorylation | down-regulates activity | 0.307 | Changing a serine residue (Ser(2054)) to aspartic acid mutated the potential protein kinase A site adjacent to NLS2(APC), resulting in both inhibition of the NLS2(APC)-mediated nuclear import of a chimeric beta-galactosidase fusion protein and a reduction of full-length APC nuclear localization. | SIGNOR-250335 |
P18031 | P25963 | 1 | dephosphorylation | down-regulates | 0.354 | Ptp1b is able to dephosphorylate phosphorylated-tyr-42 on ikappabalpha | SIGNOR-45004 |
P27361 | Q15831 | 1 | phosphorylation | down-regulates activity | 0.39 | Directly and/or through the activation of p90RSK, ERK phosphorylates LKB-1 at Ser325 and Ser428. The phosphorylation of LKB-1 causes the dissociation of LKB-1 from AMPK, resulting in the impaired activation of AMPK. | SIGNOR-209880 |
Q92830 | P0DPK2 | 1 | acetylation | down-regulates activity | 0.2 | The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. | SIGNOR-269597 |
P46934 | P42261 | 1 | ubiquitination | down-regulates quantity | 0.419 | Finally, we show that ubiquitination of GluA1 by Nedd4-1 becomes more prevalent as neurons mature.|The ability of Nedd4-1 to reduce surface GluA1 levels required its ligase activity, since co-expression of a catalytically-inactive version of Nedd4-1 (Nedd4-1 CS) did not decrease surface GluA1 levels . | SIGNOR-278572 |
O60729 | P04637 | 1 | dephosphorylation | down-regulates activity | 0.333 | The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53|. Furthermore, the hCdc14 phosphatases were found to dephosphorylate p53 specifically at the p34Cdc2/clb phosphorylation site (p53-phosphor-Ser315)|Earlier studies showed that Ser315 phosphorylation increases the sequence-sp... | SIGNOR-248332 |
Q9C0A6 | P84243 | 1 | methylation | up-regulates activity | 0.2 | SETD5 Exhibits Intrinsic Methyltransferase Activity on H3K36. This assay showed that SETD5 has specific histone methyltransferase activity toward K36 but not for other residues such as K4 and K27 (Figure 8B). we revealed that SETD5 is endowed with H3K36 methyltransferase, which is necessary for RNA elongation and proce... | SIGNOR-264622 |
Q9Y4P1 | Q9GZQ8 | 1 | cleavage | up-regulates | 0.803 | Human atg4 homologues cleave the carboxyl termini of the three human atg8 homologues, microtubule-associated protein light chain 3 (lc3), gabarap, and gate-16. | SIGNOR-125449 |
P00533 | P51452 | 0 | dephosphorylation | down-regulates activity | 0.357 | We found that EGF receptor (EGFR) was a direct substrate of VHR and that overexpression of VHR down-regulated EGFR phosphorylation, particularly at Tyr-992 residue. Expression of VHR inhibited the activation of phospholipase Cγ and protein kinase C, both downstream effectors of Tyr-992 phosphorylation of EGFR. | SIGNOR-248532 |
Q9UNW9 | Q16566 | 0 | phosphorylation | up-regulates quantity | 0.255 | CaMKIV Phosphorylates Nova-2 and Regulates Its Nuclear Localization. CaMKIV Phosphorylates Nova-2 and Regulates Its Nuclear Localization. Conversely, Nova-2 with single or double mutations to alanine (2A and 1A2A) was predominantly nuclear, like the WT (Figures 5H and and5I).5I). In contrast, glutamate mutations at s... | SIGNOR-273521 |
P38936 | Q15831 | 0 | phosphorylation | down-regulates activity | 0.488 | Mass spectrometry analysis of the phosphorylated CDKN1A identified Thr80 as the residue phosphorylated by LKB1 in vitro (Figure 4A and S5A).|UVB induced phosphorylation of LKB1 T366 mediates CDKN1A degradation. | SIGNOR-278253 |
P03372 | P06850 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.34 | Evidence of direct estrogenic regulation of human corticotropin-releasing hormone gene expression. Potential implications for the sexual dimophism of the stress response and immune/inflammatory reaction.|Gel retardation and immunoprecipitation demonstrated specific association between the perfect half-palindromic EREs ... | SIGNOR-268721 |
P10915 | P14780 | 0 | cleavage | down-regulates quantity by destabilization | 0.341 | Matrix metalloproteinases cleave at two distinct sites on human cartilage link protein. Sequencing studies of modified link protein components revealed that stromelysins-1 and -2, gelatinases A and B and collagenase cleaved specifically between His16 and Ile17, and matrilysin, stromelysin-2 and gelatinase A cleaved bet... | SIGNOR-256328 |
P11274 | Q8TBB1 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.267 | We used the Ligand of Numb protein X (LNX) family of E3s, a group of PDZ domain-containing RING-type E3 ubiquitin ligases, to demonstrate the feasibility of this strategy. Many potential substrates of LNX E3s were identified. Eight of the nine selected candidates were ubiquitinated in vitro, and two novel endogenous su... | SIGNOR-272903 |
P04049 | P28482 | 0 | phosphorylation | down-regulates activity | 0.632 | Here, we identify six residues of Raf-1 (S29, S43, S289, S296, S301, and S642) that become hyperphosphorylated in a manner coincident with Raf-1 inactivation. | Five of the identified sites are proline-directed targets of activated ERK, and phosphorylation of all six sites requires MEK signaling, indicating a negative ... | SIGNOR-249441 |
P78317 | P29590 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.487 | Upon TGF-β induction, interaction of Arkadia with phosphorylated Smad2 triggers degradation of SnoN, whereas upon arsenic treatment, interaction of Arkadia with poly-SUMO in PML nuclear bodies induces degradation of polysumoylated PML together with RNF4. | SIGNOR-272884 |
P23443 | O00418 | 1 | phosphorylation | down-regulates activity | 0.736 | We show that two such kinases, p70 s6 kinase (regulated via mtor) and p90(rsk1) (activated by erk), phosphorylate eef2k at a conserved serine and inhibit its activity | SIGNOR-109712 |
P31749 | P53602 | 1 | phosphorylation | up-regulates activity | 0.2 | Akt modulated the pathway by phosphorylating mevalonate diphosphate decarboxylase (MDD) at Ser96. These data suggest that Akt regulates Rac1 activity by directly phosphorylating MDD at Ser96, which augments Rac1 geranylgeranylation. | SIGNOR-265891 |
P63000 | P36897 | 0 | null | up-regulates activity | 0.28 | Thus, TGF-_1 rapidly stimulates activity of both RhoA and Rac1 and this activation requires ALK5/T_RI kinase activity. | SIGNOR-227496 |
P27361 | P03372 | 1 | phosphorylation | up-regulates | 0.704 | In several estrogen response element-containing genes, the s118a mutation strongly reduced induction by e(2), and u0126 did not further reduce expression. Here, we show that serines 104 (s104) and 106 (s106) are also phosphorylated by mapk in vitro and upon stimulation of mapk activity in vivo.Phosphorylation at serine... | SIGNOR-156864 |
O43294 | P06241 | 0 | phosphorylation | up-regulates activity | 0.34 | Hic-5 is a CAKbeta-binding protein localized at focal adhesions. Here we show that overexpression of CAKbeta or Fyn, but not FAK, enhanced the tyrosine phosphorylation of coexpressed Hic-5 in COS-7 cells. The Y60F mutant of Hic-5 was not phosphorylated, and Hic-5 phosphorylated on tyrosine 60 was bound specifically to ... | SIGNOR-262875 |
P20823 | Q8IVM8 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | Luciferase reporter gene constructs containing the OAT5 (SLC22A10) and OAT7 (SLC22A9) promoter regions were transactivated by HNF-1 in HepG2 cells. | SIGNOR-268982 |
P20749 | Q9BZK7 | 0 | ubiquitination | down-regulates | 0.401 | We also defined the e3 ligase tblr1 as a protein involved in bcl-3 degradation | SIGNOR-166111 |
Q14247 | P27361 | 0 | phosphorylation | up-regulates | 0.422 | Cortactin is regulated by multiple phosphorylation events, including phosphorylation of s405 and s418 by extracellular regulated kinases (erk)1/2. Erk1/2 phosphorylation of cortactin has emerged as an important positive regulatory modification, enabling cortactin to bind and activate the arp2/3 regulator neuronal wisko... | SIGNOR-165212 |
P11802 | P05067 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.258 | These include a significant increase in APP phosphorylation at Thr 668 by cdk2, cdk4, and cdk5, which increases its beta-amyloid production and APP proteolysis by the activated caspases during cell cycle ( xref ; xref ; xref ; xref ). | SIGNOR-280214 |
P04150 | O15055 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.5 | GR directly regulates transcription of circadian clock components in mouse and human primary MSCs. Per2, E4bp4, Per1, and Timeless rapidly respond to glucocorticoid stimulation. Primary glucocorticoid receptor (GR) target genes are those at which GR occupies a nearby genomic glucocorticoid response element (GRE) and re... | SIGNOR-268049 |
Q13526 | P17612 | 0 | phosphorylation | down-regulates activity | 0.2 | Pka and pkc readily phosphorylated pin1 and its ww domain in summary, we have demonstrated that phosphorylation of the pin1 ww domain on ser16 regulates its ability to function as a pser/thr-binding module. |To examine the importance of Ser16 of Pin1, it was mutated to Glu to mimic pSer, and the mutant Pin1S16E failed... | SIGNOR-112164 |
Q9UNH5 | Q96R06 | 1 | dephosphorylation | down-regulates activity | 0.2 | We also demonstrate that Cdc14A dephosphorylates Astrin, and therefore the overexpression of Cdc14A sequesters Astrin in the centrosome and results in aberrant chromosome alignment. | SIGNOR-277066 |
O75553 | P06241 | 0 | phosphorylation | down-regulates activity | 0.614 | Tyrosine phosphorylation of Dab1 by Fyn inhibits its interaction with APP, while increasing its interaction with Fyn. | SIGNOR-278476 |
Q9Y2K2 | Q53ET0 | 1 | phosphorylation | down-regulates activity | 0.635 | We found that QSK and SIK phosphorylated TORC2 at Ser171 as well as at least two additional residues, namely Ser70 and Ser348|QIK also phosphorylates the CREB co-activator TORC2, in unstimulated cells, to sequester it in the cell cytoplasm, thereby inhibiting CREB-dependent gene-expression | SIGNOR-249170 |
P06239 | Q08881 | 1 | phosphorylation | up-regulates | 0.554 | Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity. The major site of Lck phosphorylation on Itk was mapped to the conserved tyrosine (Tyr511) in the activation loop of the Itk kinase domain. | SIGNOR-251380 |
P12931 | Q13761 | 1 | phosphorylation | down-regulates activity | 0.58 | In this study, we provide evidence that Src phosphorylates RUNX3 at multiple tyrosine residues.|Our finding that Src inactivates RUNX3 by cytoplasmic sequestration in gastric cancer and breast cancer suggests that the inactivation of RUNX3 may be a key function of oncogenic kinases. | SIGNOR-278199 |
Q9NWZ3 | Q96FA3 | 1 | phosphorylation | up-regulates activity | 0.658 | The E3 ubiquitin ligase Pellino can be activated by phosphorylation in vitro, catalyzed by IL-1 receptor-associated kinase 1 (IRAK1) or IRAK4. Here, we show that phosphorylation enhances the E3 ligase activity of Pellino 1. Unusually, the full activation of Pellino 1 can be achieved by phosphorylating any one of severa... | SIGNOR-276128 |
P49841 | Q96RG2 | 0 | phosphorylation | down-regulates activity | 0.288 | In vitro, PASK directly phosphorylates GSK3\u03b2 on its inactivating phosphorylation site Ser(9).|We conclude that PASK phosphorylates and inactivates GSK3\u03b2, thereby preventing PDX-1 serine phosphorylation and alleviating GSK3\u03b2-mediated PDX-1 protein degradation in pancreatic \u03b2-cells. | SIGNOR-279639 |
P45983 | Q6JBY9 | 1 | phosphorylation | down-regulates activity | 0.286 | CapZIP was also phosphorylated rapidly by SAPK3/p38γ and SAPK4/p38δ, and even faster and more extensively by JNK1α1, these protein kinases phosphorylating CapZIP in vitro to >3, approx. 2 and >5 mol of phosphate/mol of protein respectively within a few minutes. Following tryptic digestion and C18 chromatography, furthe... | SIGNOR-263085 |
P19544 | Q93008 | 0 | deubiquitination | up-regulates quantity by stabilization | 0.2 | Here, we find that CDC14B antagonizes CDK1-mediated activating mitotic phosphorylation of the deubiquitinase USP9X at serine residue 2563, which we show to be essential for USP9X to mediate mitotic survival. Starting from an unbiased proteome-wide screening approach, we specify Wilms' tumor protein 1 (WT1) as the relev... | SIGNOR-275614 |
Q9GZV5 | Q9NRM7 | 0 | phosphorylation | down-regulates | 0.698 | Activated lats1/2 in turn phosphorylate and inhibit yap/taz transcription co-activators | SIGNOR-175787 |
O15360 | Q13131 | 0 | phosphorylation | up-regulates activity | 0.332 | FANCA was phosphorylated by AMPK at S347 and phosphorylation increased with MMC treatment. MMC-induced FANCD2 monoubiquitination and nuclear foci formation were compromised in a U2OS cell line that stably overexpressed the S347A mutant form of FANCA compared to wild-type FANCA-overexpressing cells, indicating a require... | SIGNOR-277264 |
P00519 | Q8WYQ5 | 1 | phosphorylation | up-regulates activity | 0.2 | The kinase ABL phosphorylates the microprocessor subunit DGCR8 to stimulate primary microRNA processing in response to DNA damage. When coexpressed in HEK293T cells, ABL phosphorylated DGCR8 at Tyr(267). | SIGNOR-262604 |
P31146 | Q00535 | 0 | phosphorylation | up-regulates activity | 0.288 | We here show that phosphorylation of coronin 1 on Thr(418/424) by cyclin-dependent kinase (CDK) 5 activity was responsible for coronin 1-G_s association and the modulation of cAMP production. Together these results show an essential role for CDK5 activity in promoting the coronin 1-dependent cAMP/PKA pathway. | SIGNOR-245187 |
Q6ZWH5 | P04637 | 1 | phosphorylation | up-regulates activity | 0.256 | Here, we describe a function for NEK10 in the regulation of p53 transcriptional activity through tyrosine phosphorylation. NEK10 loss increases cellular proliferation by modulating the p53-dependent transcriptional output. NEK10 directly phosphorylates p53 on Y327, revealing NEK10's unexpected substrate specificity. A... | SIGNOR-273881 |
Q7Z2E3 | P05129 | 0 | phosphorylation | up-regulates | 0.32 | We show the novel molecular consequences of increased kinase activities of mutants: aprataxin (aptx), a dna repair protein causative for autosomal recessive ataxia, was found to be a preferential substrate of mutant pkc gamma, and phosphorylation inhibited its nuclear entry. ollectively, phosphorylation occurred at th... | SIGNOR-186409 |
O60315 | P11473 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | ZEB, a Krüppel-type transcription factor known to repress the transcription of several genes, binds to two sites within the VDR promoter and activates the transcription of this receptor in a cell-specific manner. Transfection of ZEB into SW620 colon carcinoma cells results in an up-regulation of the expression of endog... | SIGNOR-268954 |
Q13043 | Q9NRM7 | 1 | phosphorylation | up-regulates | 0.636 | Activation of mst1/2 leads to phosphorylation and activation of their direct substrates, lats1/2. | SIGNOR-175821 |
P61073 | P54578 | 0 | deubiquitination | up-regulates quantity by stabilization | 0.448 | The physical interaction of CXCR4 and USP14 is paralleled by USP14-catalyzed deubiquitination of the receptor|We also observed that ubiquitination of CXCR4 facilitated receptor degradation, whereas overexpression of USP14 or RNAi-induced knockdown of USP14 blocked CXCL12-mediated CXCR4 degradation | SIGNOR-265057 |
P29320 | P18031 | 0 | dephosphorylation | down-regulates activity | 0.417 | Nevertheless, the finding that phosphorylation of the activation loop tyrosine (EphA3-Y779), a recently identified PTP1B substrate (Mertins et al., 2008), is essential for ligand-induced endocytosis (Janes et al., 2009) | SIGNOR-248426 |
Q9P0J1 | O60674 | 0 | phosphorylation | down-regulates activity | 0.264 | Here we report that phosphorylation at another tyrosine residue, Tyr-94, inhibits PDP1 by reducing the binding ability of PDP1 to lipoic acid, which is covalently attached to the L2 domain of dihydrolipoyl acetyltransferase (E2) to recruit PDP1 to PDC. We found that multiple oncogenic tyrosine kinases directly phosphor... | SIGNOR-276642 |
P63000 | O75044 | 0 | gtpase-activating protein | down-regulates activity | 0.588 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260516 |
P42345 | O00141 | 1 | phosphorylation | up-regulates | 0.849 | Mtor phosphorylated sgk1, but not sgk1-s422a, in vitro. Sgk1 phosphorylated p27 in vitro. These data implicate sgk1 as an mtorc1 (mtor-raptor) substrate. mtor may promote g1 progression in part through sgk1 activation | SIGNOR-179113 |
P78527 | P49917 | 1 | phosphorylation | down-regulates | 0.808 | Using tandem mass spectrometry, we identified a dna-pk phosphorylation site at thr-650 in human lig4 and a potential second phosphorylation site at ser-668 or ser-672. Phosphorylation of lig4 per se was not required for lig4 dna end joining activity. Substitution of these amino acids with alanine, individually or in co... | SIGNOR-125877 |
O15027 | P28482 | 0 | phosphorylation | up-regulates activity | 0.352 | Recombinant active ERK2 also phosphorylated Sec16 (XREF_FIG). | SIGNOR-280022 |
P01880 | Q86YJ5 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | MARCH9, a member of the RING-CH family of transmembrane E3 ubiquitin ligases, down-regulates CD4, major histocompatibility complex-I (MHC), and ICAM-1 in lymphoid cells. To identify novel MARCH9 substrates, we used high throughput flow cytometry and quantitative mass spectrometry by stable isotope labeling by amino aci... | SIGNOR-271542 |
P49815 | Q15382 | 1 | gtpase-activating protein | down-regulates activity | 0.922 | Tsc2 functions as a gap to inhibit rheb activity. Tsc2 displays gap (gtpase-activating protein) activity specifically towards the small g protein rheb and inhibits its ability to stimulate the mtor signaling pathway. It has recently been shown that tsc2 has gtpase-activating protein (gap) activity towards the ras famil... | SIGNOR-128432 |
Q9H3R0 | Q16695 | 1 | demethylation | down-regulates activity | 0.2 | As one member of the Jumonji-C histone demethylase family, JMJD2C has the ability to demethylate tri- or di-methylated histone 3 and 2 in either K9 (lysine residue 9) or K36 (lysine residue 36) sites by an oxidative reaction, thereby affecting heterochromatin formation, genomic imprinting, X-chromosome inactivation, an... | SIGNOR-263866 |
Q13535 | Q9Y2K6 | 1 | phosphorylation | down-regulates activity | 0.306 | On the other hand, USP20 is phosphorylated by ATR, which disrupts the interaction between USP20 and HERC2, resulting in USP20 stabilization.|USP20 phosphorylation by ATR is important for its stabilization and checkpoint activation. | SIGNOR-278393 |
Q7Z434 | Q14790 | 1 | relocalization | up-regulates | 0.587 | Another protein suggested to play a role in caspase-8 translocation to mitochondria is the mitochondrial membrane protein cardif | SIGNOR-143572 |
Q9C0A6 | Q16695 | 1 | methylation | up-regulates activity | 0.2 | SETD5 Exhibits Intrinsic Methyltransferase Activity on H3K36. This assay showed that SETD5 has specific histone methyltransferase activity toward K36 but not for other residues such as K4 and K27 (Figure 8B). we revealed that SETD5 is endowed with H3K36 methyltransferase, which is necessary for RNA elongation and proce... | SIGNOR-264621 |
P52565 | P63000 | 1 | guanine nucleotide exchange factor | down-regulates activity | 0.811 | Here, we report the expression of plexin-B3 in glioma cells, which upon stimulation by its ligand Sema5A results in significant inhibition of cell migration and invasion. A search for the underlying mechanism revealed direct interaction of plexin-B3 with RhoGDP dissociation inhibitor α (RhoGDIα), a negative regulator o... | SIGNOR-268436 |
P05412 | P28562 | 0 | dephosphorylation | down-regulates activity | 0.455 | However, adenovirus mediated overexpression of MKP-1 only slightly decreased JNK and c-Jun phosphorylation compared with the severe inactivation of JNK activities induced by MKK7 knockdown.|The results suggested that HDACI-induced MKP-1 contributes to inactivation of JNK instead of ERK, consistent with the previous rep... | SIGNOR-277102 |
P17612 | P13569 | 1 | phosphorylation | up-regulates | 0.485 | Cftr, the protein associated with cystic fibrosis, is phosphorylated on serine residues in response to camp agonists. Serines 660, 737, 795, and 813 were identified as in vivo targets for phosphorylation by protein kinase a.mutagenesis of all four sites abolished the response. | SIGNOR-21312 |
P30301 | P17612 | 0 | phosphorylation | down-regulates activity | 0.312 | Phosphorylation at one of these sites (serine 243) could be increased by A kinase in vitro. phosphorylation of MIP reconstituted into single bilayers increased the voltage dependence and long-term closures of the channels observed. | SIGNOR-250018 |
Q9UPX8 | P12814 | 1 | relocalization | up-regulates activity | 0.297 | SHANK proteins are ‘master’ scaffolding proteins that tether and organize intermediate scaffolding proteins. They are located at excitatory synapses, where they are crucial for proper synaptic development and function. SAPAP proteins subsequently bind to the PDZ domain of members of the SHANK protein family. SHANK prot... | SIGNOR-264584 |
P55211 | P31749 | 0 | phosphorylation | down-regulates activity | 0.775 | Akt phosphorylated recombinant casp9 in vitro on serine-196 and inhibited its protease activity | SIGNOR-252581 |
Q00535 | P12830 | 1 | phosphorylation | down-regulates activity | 0.298 | Using both the Cdk inhibitor roscovitine and an RNA interference strategy, it was also demonstrated that Cdh1 was phosphorylated by Cdk5, an enzyme that can be persistently activated when bound to p25 [ xref ], the proteolytic product of p35 that has previously been shown to accumulate in the neurons of patients with A... | SIGNOR-279679 |
P08581 | Q13480 | 1 | phosphorylation | up-regulates activity | 0.674 | Gab-1 is phosphorylated on the same residues by HGF and EGF receptors. Among 16 peptides only nine were phosphorylated by the EGF and HGF receptors, namely peptides containing the tyrosine residues 285, 307, 373, 407, 448, 473, 590, 628 and 660. we show that in the response to HGF or EGF, Gab1 is phosphorylated in vivo... | SIGNOR-250290 |
P04004 | P68400 | 0 | phosphorylation | up-regulates activity | 0.328 | Therefore, we expressed Vn in a baculovirus system and show (i) that the CKII phosphorylation of wt-Vn enhances the adhesion of bovine aorta endothelial cells; (ii) that the double mutant T50E/T57E (in which the neutral Thr residues are replaced by the negatively charged Glu residues considered analogs of Thr-P) has a... | SIGNOR-250971 |
P27361 | P19793 | 1 | phosphorylation | down-regulates activity | 0.523 | In colon cancer cells, the Ras/mitogen‐activated protein kinase (MAPK) pathway phosphorylates RXRalpha, which impairs its function as a heterodimeric partner for PPARgamma|A point‐mutated RXRalpha T82A/S260A, which mimics the unphosphorylated form of RXRalpha, can form a heterodimer with PPARgamma and thereby activate ... | SIGNOR-88662 |
Q99466 | Q15369 | 0 | ubiquitination | down-regulates | 0.2 | Using proteomic techniques, several components of the elongin c complex were identified as candidate notch4(icd) interactors. Elongin c complexes can function as ubiquitin ligases capable of regulating proteasomal degradation of specific protein substrates. Our studies indicate that ectopic elongin c expression stimula... | SIGNOR-176779 |
P12931 | Q92974 | 1 | phosphorylation | up-regulates activity | 0.415 | Src activates GEF-H1. | SIGNOR-277478 |
Q9UBK2 | Q969K3 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.319 | Mechanistically, PGC1α was phosphorylated at serine (S) 636 by DNA-dependent protein kinase in response to irradiation. Phosphorylation at S636 promoted the degradation of PGC1α by facilitating its binding to the E3 ligase RNF34. | SIGNOR-277912 |
P68400 | P83916 | 1 | phosphorylation | down-regulates | 0.303 | Two recent papers suggest that hp1 recruitment to damage sites, rather than its rapid mobilization, is the predominant behaviour exhibited by this protein. Our findings reconcile recent findings in a new model, wherein rapid hp1beta mobilization from dsbs is mediated by its phosphorylation on thr51 by ck2 | SIGNOR-187450 |
Q00059 | P17612 | 0 | phosphorylation | up-regulates | 0.2 | Here, we demonstrate that tfam is phosphorylated within its hmg box 1 (hmg1) by camp-dependent protein kinase in mitochondria. Hmg1 phosphorylation impairs the ability of tfam to bind dna and to activate transcription. | SIGNOR-199934 |
Q9NRC8 | Q9NR31 | 1 | deacetylation | up-regulates activity | 0.2 | SIRT7 interacts with the helicase DDX21. Deacetylation by SIRT7 is required for DDX21 activity and R-loop unwinding | SIGNOR-260978 |
P00533 | P23470 | 0 | dephosphorylation | down-regulates activity | 0.481 | PTPRG activation by the P1-WD peptide affected the tyrosine phosphorylation of several signaling molecules. Data analysis identified 31 molecules whose phosphorylation was modified in a statistically significant manner (Table I). inhibition of ABL1, BMX, BTK, DAB1, ITGB1, JAK2, KDR, KIT, LIMK1, MET, PDGFRB, SHC1, and V... | SIGNOR-254699 |
Q9BVJ7 | P27361 | 1 | dephosphorylation | down-regulates activity | 0.31 | In particular, DUSP23 can dephosphorylate and inactivate MAPK3 ( xref ).|In particular, DUSP23 can dephosphorylate and inactivate MAPK3. | SIGNOR-277103 |
Q13554 | Q14524 | 1 | phosphorylation | up-regulates activity | 0.408 | Among the sites identified, only six were previously suggested to be the targets for specific kinases using in silico and/or in vitro analyses: S36 and S525 were attributed to the regulation by PKA; S484 and S664 were assigned to the serum- and glucocorticoid-inducible kinase 3 (SGK3); and S516 and S571 were ascribed t... | SIGNOR-275773 |
Q9HCK8 | Q9BT81 | 1 | transcriptional regulation | down-regulates quantity | 0.2 | Many of the most significantly up-regulated genes in Chd8+/− and Chd8−/− NPCs are involved in later stages of neuronal development, including Ascl1 [a central driver of neural reprogramming (29)], Dcx, Map2, Nefm, Neurod4, and Neurog1 (Fig. 2 E and F). Additionally, we found that Sox3 is derepressed in both Chd8+/− and... | SIGNOR-268922 |
P11309 | P42229 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.375 | The results of 2 microarray experiments demonstrated that the aberrant activation of STAT proteins by Flt3-ITDs resulted in the up-regulation of several STAT5-responsive genes, such as Pim-1, Pim-2, and members of the SOCS (suppressor of cytokine signaling) protein family. These results are particularly interesting bec... | SIGNOR-249621 |
Q5S007 | Q96CW1 | 1 | phosphorylation | up-regulates activity | 0.259 | These data confirmed that LRRK2 phosphorylates AP2M1 at Thr 156 in vitro. | SIGNOR-278183 |
P12931 | Q13972 | 1 | phosphorylation | down-regulates activity | 0.47 | These proximal Src kinases could potentially directly or indirectly phosphorylate Rasgrf-1 upon BCR activation and thereby further increase its GEF activity. | SIGNOR-280133 |
Q15139 | A6ND36 | 1 | phosphorylation | up-regulates activity | 0.2 | Taken together, these data demonstrate that FAM83G S356 phosphorylation modulates HSP27 phosphorylation and apoptosis regulation and that HSP27 is a counterpart of FAM83G.|an active form of PKD1/PKCm could phosphorylate the FAM83G peptide, including the S356 portion.|We also demonstrated that the phosphorylation of the... | SIGNOR-264764 |
P18031 | P49759 | 0 | phosphorylation | up-regulates activity | 0.347 | The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B. | although CLK1 and CLK2 directly phosphorylate PTP-1B on both Ser50 and Ser242/Ser243, the preferred CLK phosphorylation site is Ser50, as it is preferentially phosphorylated at an approximate ratio of 9:1 over the Ser2... | SIGNOR-250773 |
P17706 | P06213 | 1 | dephosphorylation | down-regulates | 0.622 | Finally, we have tested the set of ptps for their ability to dephosphorylate a phosphopeptide corresponding to the irk autophosphorylation site. tc-ptp, sap-1, and ptp-1b all tested positive, but ptp-? Showed no activity, although the same gst-ptp preparation could efficiently convert pnpp (tablei). Interestingly, many... | SIGNOR-75914 |
Q9Y385 | Q92813 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.379 | ER residency places D2 physically close to an array of proteins that interact and modify the D2 molecule via ubiquitination and targeting to the proteasomal system, explaining its relatively short half-life. Both ubiquitin conjugases UBC6 and or UBC7 interact with D2 and support D2 ubiquitination. Two Lys residues in D... | SIGNOR-267481 |
O75376 | P37231 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.708 | In differentiated adipocyte cell lines, SIRT1 inhibits adipogenesis and enhances fat mobilization through lipolysis by suppressing the activity of PPARγ. SIRT1 achieves this by promoting the assembly of a corepressor complex, involving NCoR1 and SMRT, on the promoters of PPARγ target genes to repress their transcriptio... | SIGNOR-253507 |
P29375 | P84243 | 1 | demethylation | up-regulates activity | 0.2 | KDM5 subfamily is capable of removing tri‐ and di‐ methyl marks from lysine 4 on histone H3 (H3K4). Depending on the methylation site, its effect on transcription can be either activating or repressing. | SIGNOR-264301 |
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