IdA string | IdB string | labels int64 | mechanism string | effect string | score float64 | sentence string | signor_id string |
|---|---|---|---|---|---|---|---|
P53611 | P20339 | 1 | lipidation | up-regulates activity | 0.491 | Prenylation (or geranylgeranylation) of Rab GTPases is catalysed by RGGT (Rab geranylgeranyl transferase) and requires REP (Rab escort protein). In the classical pathway, REP associates first with unprenylated Rab, which is then prenylated by RGGT. In the alternative pathway, REP associates first with RGGT; this compl... | SIGNOR-265573 |
Q15256 | P49023 | 1 | dephosphorylation | down-regulates activity | 0.2 | Here, we show that paxillin is a direct substrate of PTPRT and that PTPRT specifically regulates paxillin phosphorylation at tyrosine residue 88 (Y88) in colorectal cancer (CRC) cells. We engineered CRC cells homozygous for a paxillin Y88F knock-in mutant and found that these cells exhibit significantly reduced cell mi... | SIGNOR-248720 |
Q00613 | Q92630 | 0 | phosphorylation | up-regulates activity | 0.318 | To test whether in a similar way DYRK2 phosphorylates and activates HSF1 in human cancer cells, we overexpressed DYRK2 and, by use of phosphospecific antibodies, we observed that the levels of endogenous HSF1 phosphorylated at S326 and S320 (two main phosphorylation events linked to HSF1 activation) were increased (Fig... | SIGNOR-278355 |
Q2M1Z3 | P49841 | 0 | phosphorylation | up-regulates activity | 0.302 | We show that GSK-3alpha and -beta interact with CdGAP in mammalian cells. We also demonstrate that GSK-3 phosphorylates CdGAP both in vitro and in vivo on Thr-776, which we have previously shown to be an ERK 1/2 phosphorylation site involved in CdGAP regulation. | SIGNOR-262879 |
Q13464 | Q2V2M9 | 1 | phosphorylation | up-regulates activity | 0.275 | In addition we were able to throw light on the mechanism of activation of FHOD3 by ROCK1 and could demonstrate the effects of constitutively active FHOD3 on actin filament synthesis in cardiomyocytes.|ROCK1 can directly phosphorylate FHOD3 and FHOD3 seems to be the downstream mediator of the exaggerated actin filament ... | SIGNOR-278903 |
O95863 | P49841 | 0 | phosphorylation | down-regulates | 0.557 | Snail is a well-known zn-finger transcription factor that promotes emt by repressing e-cadherin expression. It is known that snail is phosphorylated by gsk3beta and degraded by beta-trcp-mediated ubiquitination. A variant of snail (snail-6sa), which abolishes these phosphorylations, is much more stable and resides excl... | SIGNOR-129402 |
O43474 | P04637 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.56 | Previous work has shown that the Kruppel-like factor 4 (KLF4) transcription factor represses p53 transcription by binding to the PE21 element. | SIGNOR-270544 |
P00533 | Q92529-2 | 1 | phosphorylation | up-regulates activity | 0.617 | We also obtained tryptic phosphopeptide maps of N-Shc protein phosphorylated in vitro by other tyrosine kinases, TrkB, v-Src and EGFR. The overall patterns of the phosphopeptide maps generated by these tyrosine kinases were similar, although there were some differences among these maps (Figure 4a–d).We performed phosph... | SIGNOR-273922 |
Q9Y2H1 | P21333 | 1 | phosphorylation | up-regulates activity | 0.2 | Activated Ndr2 Promotes FLNa Release From LFA-1.|Taken together the data depicted in Figures xref and xref indicate that Ndr2 phosphorylates FLNa at S2152 both in vitro and in vivo . | SIGNOR-278501 |
Q9BQL6 | Q8IWT3 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | M-phase-specific CDK1–cyclin B1 complex directly binds KIND1 and KIND2 and phosphorylates a conserved proline-directed CDK1 consensus motif in the flexible and intrinsically disordered loop of the F1 domain. This then results in the recruitment of the CUL9–FBXL10 complex, modification with K48-linked polyubiquitin chai... | SIGNOR-276718 |
Q16539 | Q12948 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.2 | P38 interacts with and phosphorylates the Ser241 and ser272 sites of FOXC1 to maintain its stability by inhibiting ubiquitination and degradation. | SIGNOR-275913 |
P08311 | P55085 | 1 | cleavage | down-regulates activity | 0.526 | PAR1E and PAR2E (10 microM) were incubated in the presence of the different proteases | The enzymes were used at the following concentrations: 0.5 unit/mL thrombin, 2.5 nM trypsin, 20 nM plasmin, 20 nM cathepsin G, 20 nM elastase, 20 nM proteinase 3, and 2 units/mL calpain I and II|Protease-activated receptors (PARs) m... | SIGNOR-263585 |
P23769 | P31749 | 0 | phosphorylation | down-regulates | 0.524 | We show that insulin induces gata2 phosphorylation on serine 401 in a pi-3k/akt-dependent manner. Insulin-dependent phosphorylation of serine 401 impairs gata2 translocation to the nucleus and its dna binding activity | SIGNOR-135614 |
P80370 | Q9Y261 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.332 | Taken together, these data suggest that Foxa-2 is a direct transcriptional activator of the Pref-1 gene. | SIGNOR-254971 |
P13051 | P49841 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.2 | Here we show that glycogen synthase kinase 3 (GSK-3) interacts with and phosphorylates UNG2 at Thr60 and that Thr60 phosphorylation requires a Ser64 priming phosphorylation event.|phosphorylation of Thr60 and Ser64 creates a cyclin E/c-Myc-like phosphodegron that promotes polyubiquitylation and proteasome-mediated degr... | SIGNOR-264885 |
P48730 | P35222 | 1 | phosphorylation | down-regulates | 0.626 | However, ckiepsilon has been recently shown to interact with axin (sakanaka et al. 1999;rubinfeld et al. 2001), and it was proposed that this kinase mediates axin-induced apc phosphorylation, thereby stabilizing the -catenin degradation complex (rubinfeld et al. 2001). We have, therefore, evaluated cki as a candidate s... | SIGNOR-87441 |
Q14258 | Q15911 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.451 | In the present study we show that EFP (oestrogen-responsive finger protein) is an E3 ubiquitin ligase mediating oestrogen-induced ATBF1 protein degradation. Knockdown of EFP increases ATBF1 protein levels, whereas overexpression of EFP decreases ATBF1 protein levels. | SIGNOR-272048 |
Q9H3D4 | P23443 | 0 | phosphorylation | down-regulates | 0.2 | Atm kinase is a master switch for the delta np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon dna damage. We previously found that the pro-apoptotic dna damaging agent, cisplatin, mediated the proteasome-dependent degradation of delta np63 alpha associated with its increas... | SIGNOR-180771 |
P23470 | P24941 | 1 | dephosphorylation | down-regulates activity | 0.298 | PTPRG activation by the P1-WD peptide affected the tyrosine phosphorylation of several signaling molecules. Data analysis identified 31 molecules whose phosphorylation was modified in a statistically significant manner (Table I). inhibition of ABL1, BMX, BTK, DAB1, ITGB1, JAK2, KDR, KIT, LIMK1, MET, PDGFRB, SHC1, and V... | SIGNOR-254695 |
Q05209 | P12931 | 1 | dephosphorylation | up-regulates activity | 0.542 | PTP-PEST increases dephosphorylation of Src at Y527 and activates it.|The data presented here supports our hypothesis that PTP-PEST activates Src via dephosphorylating it at Y527 (Tyr530 in human c-Src equivalent to Tyr527 in chicken Src). | SIGNOR-277086 |
Q14469 | P09471 | 0 | null | down-regulates | 0.2 | GNAO1 overexpression enhances GSC differentiation by downregulating neural progenitor gene HES1 | SIGNOR-278092 |
Q6NXT2 | Q9NRC8 | 0 | deacetylation | up-regulates activity | 0.2 | Besides confirming the previously reported histone H3K18 deacylation activity, our results revealed that SIRT7 has an astonishingly high activity to catalyze deacylation of H3K36 and is also catalytically active to deacylate H3K37. | SIGNOR-275879 |
Q16659 | O95551 | 1 | phosphorylation | up-regulates activity | 0.377 | ERK3 phosphorylates TDP2 and promotes its phosphodiesterase activity, thereby upregualting TDP2-mediated DNA damage response and desensitizing lung cancer cells to Top2 inhibitor-induced growth inhibition.|In the current study, we have found that ERK3, an atypical MAPK, phosphorylates TDP2 at S60 and regulates TDP2 's ... | SIGNOR-278245 |
P28482 | O94953 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.2 | In addition, the phosphorylation of JMJD2B via p-ERK at Thr305, Ser352, Ser566 and Thr1065 contribute to JMJD2B stability. p-ERK stabilizes the JMJD2B protein level by protecting JMJD2B from ubiquitination and proteasome degradation. | SIGNOR-276744 |
Q13635 | P42574 | 0 | cleavage | down-regulates | 0.321 | Like other dependence receptors, ptc1 contains a dependence-as-associated receptor c-terminal motif that is cleaved by caspases at a conserved aspartic acid (asp 1392) in the absence of shh, to expose a proapoptotic domain. | SIGNOR-199111 |
P35222 | P04626 | 0 | phosphorylation | down-regulates activity | 0.766 | Second, ErbB2 phosphorylates \u03b2-catenin at Tyr 654, leading to dissociation of the E-cadherin-\u03b2-catenin membrane complex and increased signaling to Wnt target genes such as cyclin D1 ( ). | SIGNOR-279041 |
Q9UKB1 | P84022 | 1 | ubiquitination | up-regulates | 0.261 | Here, we show that smad3 activated by tgf-beta is degraded by the ubiquitin-proteasome pathway. Smad3 interacts with a ring finger protein, roc1, through its c-terminal mh2 domain in a ligand-dependent manner. An e3 ubiquitin ligase complex roc1-scf(fbw1a) consisting of roc1, skp1, cullin1, and fbw1a (also termed betat... | SIGNOR-108240 |
Q02156 | Q92934 | 1 | phosphorylation | down-regulates | 0.34 | Pkcs phosphorylate bad under in vitro conditions, and the association of phosphorylated bad with pkc-mu or pkc-epsilon, as shown by immunoprecipitation, indicated direct involvement of pkcs in bad phosphorylation. To confirm these results, cells overexpressing pegfp-n1, wt-bad, or bad with a single site mutated (ser112... | SIGNOR-163908 |
P01019 | P08246 | 0 | cleavage | up-regulates activity | 0.275 | Cathepsin G, elastase, and proteinase 3 are serine proteinases released by activated neutrophils. Cathepsin G can cleave angiotensinogen to release angiotensin II, but this activity has not been previously reported for elastase or proteinase 3. In this study we show that elastase and proteinase 3 can release angiotensi... | SIGNOR-256313 |
Q5T447 | Q9UNK0 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.44 | Our co-immunoprecipitation experiments show that Syntaxin 8 directly interacts with HECTd3 and that the overexpression of HECTd3 promotes the ubiquitination of Syntaxin 8. Immunoprecipitates probed with the anti-ubiquitin (Santa Cruz) antibody could be recognized by the anti-ubiquin antibody (Fig. 3a), indicating that... | SIGNOR-271772 |
P16070 | O14672 | 0 | cleavage | up-regulates activity | 0.346 | The ADAM proteases are best known for their role in shedding the extracellular domain of transmembrane proteins. Among the transmembrane proteins shed by ADAM10 are notch, HER2, E-cadherin, CD44, L1 and the EGFR ligands, EGF and betacellulin. | SIGNOR-259847 |
O60674 | Q92783 | 1 | phosphorylation | up-regulates | 0.617 | Stam is associated with jak3 and jak2 tyrosine kinases via its itam region and phosphorylated by jak3 and jak2 upon stimulation with il-2. | SIGNOR-47834 |
Q13535 | Q9Y253 | 1 | phosphorylation | up-regulates | 0.415 | Atr-mediated phosphorylation of dna polymerase _ is needed for efficient recovery from uv damage. We show that, after uv irradiation, pol_ becomes phosphorylated at ser601 by the ataxia-telangiectasia mutated and rad3-related (atr) kinase. Atr-dependent phosphorylation of pol_ is necessary to restore normal survival an... | SIGNOR-171290 |
P19174 | P08631 | 0 | phosphorylation | up-regulates activity | 0.681 | The phosphorylation of purified phospholipase C-gamma 1 (PLC-gamma 1) and PLC-gamma 2 by src-family-protein tyrosine kinases (PTKs) P56lck, p53/56lyn, p59hck, p59fyn, and p60src was studied in vitro. All five PTKs phosphorylated PLC-gamma 1 and PLC-gamma 2, suggesting that both PLC-gamma isozymes can be phosphorylated ... | SIGNOR-249361 |
Q9Y4K3 | O43561 | 1 | ubiquitination | up-regulates activity | 0.345 | Interestingly, this study has demonstrated that the membrane-proximal region of linker for activation of T cells preceding tyrosine-132 mediates its association with TRAF6, which promotes the ubiquitination of linker for activation of T cells and, in turn, the phosphorylation of tyrosine residues on linker for activati... | SIGNOR-278675 |
Q16665 | Q9UBF6 | 0 | ubiquitination | down-regulates activity | 0.2 | SAG (Sensitive to Apoptosis Gene), also known as RBX2 (RING box protein 2), ROC2 (Regulator of Cullins 2), or RNF7 (RING Finger Protein 7), was originally cloned in our laboratory as a redox inducible antioxidant protein and later characterized as the second member of the RBX/ROC RING component of the SCF (SKP1-CUL-F-b... | SIGNOR-271450 |
P35998 | Q05086 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.385 | Our experiments collectively suggest that UBE3A stimulates Wnt pathway activation by interacting with, ubiquitinating, and reducing the levels of multiple (PSMB1, PSMC2, PSMD2, and PSMD7) proteasome subunits. | SIGNOR-265132 |
P17252 | Q8TD43 | 1 | phosphorylation | up-regulates | 0.2 | Phorbol ester-induced activation of protein kinase c (pkc) increased the ca(2+) sensitivity of wild-type trpm4 but not of two mutants mutated at putative pkc phosphorylation sites. | SIGNOR-132243 |
O00418 | Q13131 | 0 | phosphorylation | down-regulates activity | 0.492 | AMPK can phosphorylate three sites in eEF2 kinase in vitro. Of these, Ser-398 appears to be more efficiently phosphorylated than either Ser-78 or Ser-366. Ser-78 and Ser-366 do not appear to be phosphorylated by AMPK within cells. Ser-366 serves to decrease the activity of eEF2 kinase | SIGNOR-250314 |
P49840 | O15084 | 1 | phosphorylation | down-regulates activity | 0.2 | We provide evidence for a dual kinase-mediated regulation of the PITK holoenzyme whereby PITK phosphorylation at S1017 is catalyzed by calcium/calmodulin-dependent kinase II-delta (CaMKIIdelta), promoting the subsequent phosphorylation of S1013 by glycogen synthase kinase-3 (GSK3) in vitro.|the phosphorylation of PITK ... | SIGNOR-264792 |
Q05193 | Q13627 | 0 | phosphorylation | down-regulates | 0.416 | Mnb/dyrk1a was shown to phosphorylate dynamin 1 and alter its interactions with several sh3 domain-containing endocytic accessory proteins.Phosphorylation At s795 and s857 was confirmed in full-length dynamin 1, and s857 was subsequently determined to be the major mnb/dyrk1a phosphorylation site in vitro. Phosphorylati... | SIGNOR-127440 |
P49716 | P49841 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.384 | Phosphorylation of C/EBPdelta by GSK-3beta is required for its degradation by FBXW7alpha. | SIGNOR-279180 |
P08311 | P05546 | 1 | cleavage | down-regulates activity | 0.444 | Amino acid sequence analysis led to the conclusion that both neutrophil elastase and cathepsin G cleave HC at Ile66, which does not affect HC activity, and at Val439, near the reactive site Leu444, which inactivates HC. | SIGNOR-256509 |
P15172 | P26651 | 0 | post transcriptional regulation | down-regulates quantity by destabilization | 0.292 | The TTP binding site in the 3′ UTR of MyoD would permit TTP-mediated mRNA decay | SIGNOR-253597 |
P12931 | Q9UL51 | 1 | phosphorylation | up-regulates activity | 0.267 | We identified a highly conserved tyrosine residue in the C-linker of HCN channels (Tyr476 in HCN2) that confers modulation by Src. Replacement of this tyrosine by phenylalanine in HCN2 or HCN4 abolished sensitivity to Src inhibitors. Mass spectrometry confirmed that Tyr476 is phosphorylated by Src. Our results have fun... | SIGNOR-263199 |
P53041 | Q16543 | 1 | dephosphorylation | down-regulates activity | 0.672 | Activation of protein kinase clients by the Hsp90 system is mediated by the cochaperone protein Cdc37. Cdc37 requires phosphorylation at Ser13|PP5/Ppt1 regulates phosphorylation of Ser13-Cdc37 in vivo, directly affecting activation of protein kinase clients by Hsp90-Cdc37. | SIGNOR-248539 |
Q92769 | P33076 | 1 | deacetylation | down-regulates quantity by repression | 0.413 | We report that CIITA and histone deacetylase 2 (HDAC2) interact in smooth muscle cells and macrophages as assayed by co-immunoprecipitations. HDAC2 deacetylates CIITA whereas both the HDAC inhibitor trichostatin A (TSA) and over-expression of HDAC2 interfering RNA increase CIITA acetylation. HDAC2 down-regulates CIITA ... | SIGNOR-254231 |
Q9Y577 | Q07820 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.444 | Here, we identified Trim17 as a novel E3 ubiquitin-ligase for Mcl-1. Indeed, Trim17 co-immunoprecipitated with Mcl-1. Trim17 ubiquitinated Mcl-1 in vitro. Overexpression of Trim17 decreased the protein level of Mcl-1 in a phosphorylation- and proteasome-dependent manner. Finally, knock down of Trim17 expression reduced... | SIGNOR-272032 |
Q96FW1 | P04637 | 1 | deubiquitination | up-regulates quantity by stabilization | 0.565 | Furthermore, although OTUB1 dramatically induced p53 deubiquitination, its mutant (S16A) and deletion mutant did not have this effec | SIGNOR-276528 |
P41212 | P27361 | 0 | phosphorylation | down-regulates | 0.317 | Tel became phosphorylated by erk on two serine residues, ser213 and ser257, in the internal domain between the hlh and ets domains. Tel lost its abilities to repress transcription through the phosphorylation. | SIGNOR-123656 |
P54646 | Q8IYT8 | 0 | phosphorylation | down-regulates | 0.304 | We could prove that ulk1-mediated phosphorylation of ampk reduced its level of phosphorylation at t172 of the _-subunit and hence interferes with its catalytic activity. I | SIGNOR-173089 |
Q99558 | Q13489 | 0 | ubiquitination | down-regulates | 0.65 | Ciap1/2 (cellular inhibitor of apoptosis 1 and 2) ubiquitinate nik for degradation. | SIGNOR-167298 |
O43353 | Q8WWF5 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | Collectively, ZNRF4 degrades RIP2 protein by targeting the RIP2CARD domain in an E3-ubiquitin ligase activity dependent manner.|Here we show that ZNRF4 induces K48-linked ubiquitination of RIP2 and promotes RIP2 degradation. | SIGNOR-278684 |
P28328 | P28288 | 1 | ubiquitination | up-regulates activity | 0.401 | PEX5 and PMP70 are ubiquitinated by PEX2 during amino acid starvation. | SIGNOR-278708 |
P35611 | Q13464 | 0 | phosphorylation | up-regulates | 0.376 | Rho-associated kinase (rho- kinase), which is activated by the small guanosine triphosphatase rho, phosphorylates alpha-adducin and thereby enhances the f-actin-binding activity of alpha-adducin in vitro. Here we identified the sites of phosphorylation of alpha-adducin by rho-kinase as thr445 and thr480 | SIGNOR-66996 |
P35221 | P68400 | 0 | phosphorylation | down-regulates | 0.39 | We demonstrate here that egfr activation results in disruption of the complex of beta-catenin and alpha-catenin, thereby abrogating the inhibitory effect of alpha-catenin on beta-catenin transactivation via ck2alpha-dependent phosphorylation of alpha-catenin at s641. | SIGNOR-161847 |
Q9P0L2 | P10636 | 1 | phosphorylation | down-regulates activity | 0.429 | We have studied the relationship between the phosphorylation of tau by several kinases (MARK, PKA, MAPK, GSK3) and its assembly into PHFs. MARK and PKA phosphorylate several sites within the repeats (notably the KXGS motifs including Ser262, Ser324, and Ser356, plus Ser320). This type of phosphorylation strongly reduce... | SIGNOR-250173 |
P05412 | P01112 | 0 | phosphorylation | up-regulates activity | 0.5 | c-Jun was first shown to be phosphorylated in its transactivation domain (Ser-63 and Ser-73) by ERKs and p54-JNK. This is consistent with other studies which show that PD98059 inhibits up-regulation of c-Jun protein in Ras-transformed NIH-3T3 cells | SIGNOR-235522 |
Q02878 | Q00987 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.432 | Furthermore, we also demonstrated that RPL6 is a substrate for HDM2-mediated ubiquitination and proteasomal degradation.|The interaction of RPL6 and HDM2 drives HDM2 mediated RPL6 polyubiquitination and proteasomal degradation. | SIGNOR-278630 |
O15550 | P31270 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.263 | Evidence for direct involvement of UTX in regulation of HOX gene activity was demonstrated through UTX knockdown experiments in HEK293T cells in which loss of UTX induced transcriptional repression of HOXA and HOXC clusters. | SIGNOR-260021 |
P27361 | Q14247 | 1 | phosphorylation | up-regulates | 0.422 | Cortactin is regulated by multiple phosphorylation events, including phosphorylation of s405 and s418 by extracellular regulated kinases (erk)1/2. Erk1/2 phosphorylation of cortactin has emerged as an important positive regulatory modification, enabling cortactin to bind and activate the arp2/3 regulator neuronal wisko... | SIGNOR-165212 |
Q12778 | P24941 | 0 | phosphorylation | down-regulates | 0.652 | Cdk2 specifically phosphorylated foxo1 at serine-249 (ser249) in vitro and in vivo. Phosphorylation of ser249 resulted in cytoplasmic localization and inhibition of foxo1. | SIGNOR-150028 |
Q9NPB6 | P37173 | 0 | phosphorylation | up-regulates | 0.466 | We demonstrate that Par6, a regulator of epithelial cell polarity and tight-junction assembly, interacts with TGFbeta receptors and is a substrate of the type II receptor, TbetaRII. [...] These data suggest that T_RII phosphorylates Par6 at its penultimate residue, Ser345. | SIGNOR-227484 |
Q15256 | P17612 | 0 | phosphorylation | down-regulates activity | 0.343 | The PKA phosphorylation site on PTP-SL was identified as the Ser(231) residue. treatment of COS-7 cells with PKA activators, or overexpression of the Calpha catalytic subunit of PKA, inhibited the cytoplasmic retention of ERK2 and p38alpha by wild-type PTP-SL, but not by a PTP-SL S231A mutant.‚ | SIGNOR-250038 |
P00519 | P15941 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.455 | The results demonstrate that ABL1 phosphorylates MUC1 on Tyr-60 and forms a complex with MUC1 by binding of the ABL1 SH2 domain to the pTyr-60 site. | SIGNOR-260830 |
O00139 | Q6IQ55 | 0 | phosphorylation | down-regulates activity | 0.406 | TTBK2 phosphorylates KIF2A primarily at growing MT ends and counteracts the depolymerization activity of KIF2A | SIGNOR-260926 |
P53350 | Q9H2D6 | 1 | phosphorylation | up-regulates | 0.335 | Here we show that tara is a novel polo-like kinase 1 (plk1) target protein. Plk1 interacts with and phosphorylates tara in vivo and in vitro. Actually, the thr-457 in tara was a bona fide in vivo phosphorylation site for plk1. Interestingly, we found that the centrosomal localization of tara depended on the thr-457 pho... | SIGNOR-198353 |
P49841 | Q13237 | 0 | phosphorylation | down-regulates activity | 0.258 | These data indicate that hypertrophic differentiation of growth plate chondrocytes during skeletal growth is promoted by phosphorylation and inactivation of GSK-3beta by cGKII. | SIGNOR-280095 |
Q13490 | Q14249 | 1 | ubiquitination | up-regulates activity | 0.468 | Alternatively, cIAP1 may mediate a vital function of EndoG other than cell death.|Cellular inhibitor of apoptosis protein 1 ubiquitinates endonuclease G but does not affect endonuclease G-mediated cell death. | SIGNOR-278605 |
P23470 | Q8WV28 | 1 | dephosphorylation | up-regulates activity | 0.2 | PTPRG activation by the P1-WD peptide affected the tyrosine phosphorylation of several signaling molecules. Data analysis identified 31 molecules whose phosphorylation was modified in a statistically significant manner (Table I). inhibition of ABL1, BMX, BTK, DAB1, ITGB1, JAK2, KDR, KIT, LIMK1, MET, PDGFRB, SHC1, and V... | SIGNOR-254692 |
Q9GZQ8 | Q9NR19 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | As expected, we found that glucose deprivation induced the binding of TFEB (Figure S4C) and ACSS2 (Figure S4D) to the promoter regions of MAP1LC3B, ATG3, and WIPI-1 as well as mRNA (Figure 3H) and protein (Figure 3I) expression of these genes; | SIGNOR-276562 |
P23588 | P23443 | 0 | phosphorylation | up-regulates | 0.776 | S6k1/s6k2 specifically phosphorylate ser422 in vitro. Substitution of ser422 with ala results in a loss of activity in an in vivo translation assay, indicating that phosphorylation of this site plays an important role in eif4b function. | SIGNOR-123997 |
P53350 | Q76N32 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.44 | We show that the intercentrosomal linker protein Cep68 is degraded in prometaphase through the SCF(βTrCP) (Skp1-Cul1-F-box protein) ubiquitin ligase complex. Cep68 degradation is initiated by PLK1 phosphorylation of Cep68 on Ser 332, allowing recognition by βTrCP. | SIGNOR-275621 |
P42229 | Q07817 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.653 | FLT3-ITD-TKD dual mutants induce hyperactivation of STAT5 and up-regulation of its downstream targets Bcl-x(L) and RAD51 in Ba/F3 cells | SIGNOR-261551 |
Q13315 | Q9NZM5 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.2 | PICT-1 S233 and T289 were identified as the key phosphorylation sites in this pathway, as mutating both to alanine abolished UVB-induced increase of PICT-1 phosporylation. Inhibition of PIKKs or ATM (with wortmannin and KU55933, respectively) prevented the agglomeration and degradation of PICT-1, suggesting that ATM is... | SIGNOR-273506 |
P25098 | P41143 | 1 | phosphorylation | down-regulates activity | 0.2 | Taken together, we have demonstrated that agonist-induced opioid receptor phosphorylation occurs exclusively at two phosphate acceptor sites (T358 and S363) of GRK2 at the DOR carboxyl terminus. | SIGNOR-249660 |
Q05655 | Q16236 | 1 | phosphorylation | up-regulates activity | 0.371 | Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription. | SIGNOR-249161 |
P78504 | Q86YT6 | 0 | ubiquitination | up-regulates activity | 0.693 | Mib1 is essential for the generation of functional notch ligands and regulates the classical notch ligands dll1, dll4, jag1, and jag2 in vertebrates mib1 is an essential e3 ubiquitin ligase for jag1 in the developing cerebellum. | SIGNOR-97388 |
P04637 | P19525 | 0 | phosphorylation | up-regulates | 0.571 | The double-stranded rna activated protein kinase pkr physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro. | SIGNOR-68033 |
P00519 | P37840 | 1 | phosphorylation | up-regulates quantity | 0.424 | C-Abl interacts with alpha-synuclein and phosphorylates alpha-synuclein at Y39 (XREF_FIG) . | SIGNOR-279582 |
P49841 | Q99612 | 1 | phosphorylation | up-regulates activity | 0.2 | Functionally, GSK3beta enhanced KLF6 mediated growth suppression, which was abrogated by the KLF6-4A phosphomutant.|These data establish that GSK3\u03b2 directly phosphorylates KLF6, which augments its induction of p21 and resultant growth suppression. | SIGNOR-279373 |
Q00987 | P98177 | 1 | ubiquitination | down-regulates activity | 0.63 | Mdm2 Induces Mono-Ubiquitination of FOXO4.|higher amounts of Mdm2 transfected resulted in reduced FOXO4 transcriptional activity. | SIGNOR-278656 |
O60496 | P23470 | 0 | dephosphorylation | up-regulates activity | 0.2 | PTPRG activation by the P1-WD peptide affected the tyrosine phosphorylation of several signaling molecules. Data analysis identified 31 molecules whose phosphorylation was modified in a statistically significant manner (Table I). inhibition of ABL1, BMX, BTK, DAB1, ITGB1, JAK2, KDR, KIT, LIMK1, MET, PDGFRB, SHC1, and V... | SIGNOR-254698 |
O15162 | Q05655 | 0 | phosphorylation | up-regulates | 0.424 | Following the induction of apoptosis, however, phosphorylation of serine residues decreased and it increased on threonine, consistent with the predicted pkc phosphorylation site at thr-161. Transfection of cho cells with scramblase and pkc_, but not scramblase or pkc_ alone, increased scramblase activity | SIGNOR-76904 |
P17706 | P09619 | 1 | dephosphorylation | down-regulates activity | 0.564 | The PDGF beta receptor is negatively regulated by protein tyrosine phosphatases (PTPs).|In summary, our findings identify TC-PTP as a previously unrecognized negative regulator of PDGF beta receptor signaling and support the general notion that PTPs display site selectivity in their action on tyrosine kinase receptors.... | SIGNOR-248389 |
P17612 | Q92736 | 1 | phosphorylation | up-regulates activity | 0.478 | PKA-mediated hyperphosphorylation of a conserved serine, Ser-2843 in skeletal RyR and Ser-2809 in cardiac RyR, results in an aberrant SR function during heart failure. hyperphosphorylated RyRs are leaky and therefore lead to a reduced SR Ca2+ load and impaired contractile function in heart failure | SIGNOR-250079 |
P07949 | Q12913 | 0 | dephosphorylation | down-regulates activity | 0.277 | The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins.|PTPRJ expression induces dephosphorylation of the RET(C634R) and, probably via an indirect mechanism, RET/PTC1 oncoproteins on two key RET autophosphorylation sites (Tyr1062 and Tyr905). This... | SIGNOR-248701 |
P25963 | O14965 | 0 | phosphorylation | down-regulates activity | 0.541 | The results of the in vitro kinase assay, using purified human recombinant AURKA and IkappaBalpha proteins, confirmed that AURKA can directly phosphorylate IkappaBalpha (Ser32) at a concentration as low as 2.5 ng/mul (XREF_FIG).|While an earlier study suggested that AURKA down-regulates IkappaBalpha indirectly through ... | SIGNOR-278912 |
O00213 | P00519 | 0 | phosphorylation | up-regulates | 0.415 | The c-abl tyrosine kinase phosphorylates the fe65 adaptor protein to stimulate fe65/amyloid precursor protein nuclear signaling. Here, we show that active c-abl stimulates app/fe65-mediated gene transcription and that this effect is mediated by phosphorylation of fe65 on tyrosine 547 within its second ptb domain. | SIGNOR-123476 |
P06493 | Q16512 | 1 | phosphorylation | up-regulates activity | 0.436 | CDK1 phosphorylates PKN1 at S533, S537, S562, and S916 in vitro and in cells during drug-induced mitotic arrest. Immunofluorescence staining further confirmed that PKN1 phosphorylation occurs during normal mitosis in a CDK1-dependent manner.Knockdown of PKN1 significantly inhibited anchorage-independent growth and migr... | SIGNOR-276831 |
P36873 | O15169 | 1 | dephosphorylation | down-regulates activity | 0.269 | The data suggest that PP1 controls Wnt signaling through interaction with, and regulated dephosphorylation of, axin| Axin phosphorylation markedly enhances the binding of glycogen synthase kinase 3, leading to a more active beta-catenin destruction complex. Wnt-regulated changes in axin phosphorylation, mediated by PP1... | SIGNOR-248494 |
O00743 | O43318 | 1 | dephosphorylation | down-regulates activity | 0.372 | Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway|From proteomic analysis of TAK1-binding proteins, we identified protein phosphatase 6 (PP6), a type-2A phosphatase, and demonstrated that PP6 associated with and inactivated TAK1 by dephosphorylation of Thr-187. | SIGNOR-248292 |
Q96PU5 | P35498 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.292 | The control of Nav density at the cell membrane is crucial to ensuring normal neuronal excitability. Navs are subject to posttranslational modifications that may influence their cell membrane availability. Ubiquitylation is a key process that orchestrates the internalization and subsequent degradation or recycling of ... | SIGNOR-253457 |
Q12948 | Q16539 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.2 | P38 interacts with and phosphorylates the Ser241 and ser272 sites of FOXC1 to maintain its stability by inhibiting ubiquitination and degradation. | SIGNOR-275913 |
P08581 | Q92990 | 1 | relocalization | down-regulates | 0.331 | Significantly, nonphosphorylated hgf receptor prevents fap68 from stimulating p70s6k. fap68 binding to met requires the last 30 amino acids of the c-terminal tail, which are unique to the hgf receptor. | SIGNOR-110726 |
P53350 | Q99741 | 1 | phosphorylation | up-regulates | 0.566 | Binding between cdc6 and plk1 occurs through the polo-box domain of plk1, and cdc6 is phosphorylated by plk1 on t37. These results suggest that plk1-mediated phosphorylation of cdc6 promotes the interaction of cdc6 and cdk1, leading to the attenuation of cdk1 activity, release of separase, and subsequent anaphase progr... | SIGNOR-169184 |
P55010 | P68400 | 0 | phosphorylation | up-regulates | 0.394 | We find that eif5 is associated with ck2 when the kinase activity is at the highest level in vivo, and is phosphorylated at ser389 and ser390 by ck2. | SIGNOR-141159 |
O00311 | P49736 | 1 | phosphorylation | up-regulates | 0.962 | In this work, by in vitro kinase reactions and mass spectrometry analysis of the products, we have mapped phosphorylation sites in the n terminus of mcm2 by cdc7, cdk2, cdk1, and ck2 | SIGNOR-143984 |
P49841 | O75925 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.332 | We discovered a ubiquitin E3 ligase, HECTD2, which ubiquitinated and mediated the degradation of PIAS1, thus increasing inflammation in an experimental pneumonia model. We found that GSK3β phosphorylation of PIAS1 provided a phosphodegron for HECTD2 targeting. | SIGNOR-276923 |
Q9BXM7 | P10636 | 1 | phosphorylation | down-regulates activity | 0.384 | Simultaneously overexpressing PINK1 significantly reduced the levels of exogenous total and phosphorylated tau proteins (Figures 4A,B,E).|Taken together, our data revealed that PINK1 overexpression promoted degradation of abnormal accumulated tau via the autophagy-lysosome pathway, indicating that PINK1 may be a potent... | SIGNOR-279250 |
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