IdA string | IdB string | labels int64 | mechanism string | effect string | score float64 | sentence string | signor_id string |
|---|---|---|---|---|---|---|---|
P04637 | Q70YC5 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.29 | Here, analysis of p53-regulated genes activated in the setting of telomere dysfunction identified Zfp365 (ZNF365 in humans) as a direct p53 target that promotes genome stability| Our study identified ZNF365 as a necessary target whose activation by p53 in the presence of critically short telomeres contributes to genomi... | SIGNOR-272476 |
P11274 | P07332 | 0 | phosphorylation | down-regulates activity | 0.368 | In the present study, we demonstrate that BCR Tyr-246 and at least one of the closely spaced tyrosine residues, Tyr-279, Tyr-283, and Tyr-289 (3Y cluster), are phosphorylated by FES both in vitro and in 32Pi-labeled cells. Co-expression of BCR and FES in human 293T cells stimulated the tyrosine autophosphorylation of F... | SIGNOR-251137 |
Q8NEM2 | P04626 | 0 | phosphorylation | up-regulates activity | 0.2 | Blocking HER2 activation using trastuzumab effectively abolished EGF-induced nuclear localization of SHCBP1 in gastric cancer cells [7].|In addition, nuclear translocation of SHCBP1 is a downstream consequence of HER2 activation, which is dependent on phosphorylation of SHCBP1 at the Ser273 site. | SIGNOR-280009 |
P23528 | Q96S53 | 0 | phosphorylation | down-regulates activity | 0.503 | Like tesk1, tesk2 phosphorylated cofilin specifically at ser-3 and induced formation of actin stress fibers and focal adhesions. | SIGNOR-108753 |
P49662 | Q63HK5 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.27 | Chromatin immunoprecipitation showed a direct interaction of FE65 and Teashirt3 with the promoter region of CASP4. The results were consistent with a model in which reduced expression of Teashirt3, mediated by genetic or other causes, increases caspase-4 expression, leading to progression of AD. | SIGNOR-264815 |
P22455 | P42224 | 1 | phosphorylation | up-regulates activity | 0.348 | Activation of Stat1 and Stat3 by FGFR derivatives. Lysates of 293T cells transfected as indicated were analysed by Western blotting using Phospho-Stat1 (Y701) antisera (top) or Stat1 antisera (bottom). (b) The same lysates in (a) were re-examined for phosphorylated Stat3 by Western blotting with Phospho-Stat3 (Y705) (t... | SIGNOR-251141 |
Q9BT67 | P46934 | 1 | relocalization | up-regulates activity | 0.589 | Ndfip1 is primarily localized in the Golgi apparatus where it recruits Nedd4-2 to mediate the degradation of mature hERG proteins during channel trafficking to the plasma membrane. Although Ndfip2 directs Nedd4-2 to the Golgi apparatus, it also recruits Nedd4-2 to the multivesicular bodies (MVBs), which may impair MVB ... | SIGNOR-260997 |
Q8WU20 | Q06124 | 1 | phosphorylation | up-regulates | 0.78 | In addition to the direct interactions with grb2, tyrosine-phosphorylated frs2 forms a complex with the sh2 domain-containing protein tyrosine phosphatase shp2. This interaction results in tyrosine phosphorylation of shp2 and complex formation between shp2 and grb2. the catalytic activity of shp2 is essential for a su... | SIGNOR-58196 |
Q9H9S0 | Q02156 | 0 | phosphorylation | up-regulates activity | 0.329 | Taken together, our results demonstrate that PKC\u03b5-mediated phosphorylation at T200 and T280 enhances Nanog protein stability in head and neck squamous cell carcinoma.|These observations confirm that PKCepsilon modulates Nanog transcriptional activity and demonstrate that Nanog is phosphorylated by PKCepsilon at T2... | SIGNOR-278203 |
O00327 | Q14995 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.467 | A retinoic acid receptor-related orphan receptor (ROR) response element within the BMAL1 promoter is responsive to both ROR and REV-ERB (encoded by the genes NR1D1 and NR1D2); ROR activates the transcription of BMAL1, whereas REV-ERB suppresses its transcription. | SIGNOR-268006 |
O15111 | Q8N3F0 | 1 | phosphorylation | down-regulates activity | 0.2 | INKIT interacted with IKKα/β and TBK1/IKKɛ, impairing the recruitment and phosphorylation of p65 and IRF3. Viral infection induced IKK-mediated phosphorylation of INKIT at Ser58, resulting in its dissociation from the IKKs. Our findings thus uncover INKIT as a regulator of innate antiviral responses. | SIGNOR-273612 |
O75496 | P00519 | 0 | phosphorylation | up-regulates activity | 0.355 | Taken together, suggests that c-Abl binds and phosphorylates geminin on Y150 in G2/M/early G1 phases. | SIGNOR-278505 |
P01178-PRO_0000020496 | P16519 | 0 | cleavage | up-regulates quantity | 0.2 | Oxytocin-extended form is further cleaved by enzymatic activity to yield the nine-amino-acid active peptide, OT. The proteolysis may involve several pro-hormone convertases, convertase 2 (PC2) (20p11-1-11.2) and convertase 5 (PC5) (9q21.3) (Gabreels et al 1998). Both enzymes are found in OT neurosecretory vesicles and ... | SIGNOR-270337 |
Q5TKA1 | Q00526 | 0 | phosphorylation | up-regulates | 0.2 | In this report, we demonstrate that cyclin e1/cdk3 phosphorylates lin-9 on thr-96. Mutating thr-96 to alanine inhibits activation of cyclins a2 and b1 promoters, whereas a phosphomimetic asp mutant strongly activates their promoters and triggers accelerated entry into g2/m phase in 293t cells. | SIGNOR-204529 |
P13498 | Q05655 | 0 | phosphorylation | up-regulates | 0.2 | Phosphorylation of p22phox on threonine 147 enhances NADPH oxidase activity by promoting p47phox binding. | Threonine 147 of p22phox Is Phosphorylated by PKC-α and PKC-δ in Vitro | SIGNOR-260892 |
Q9BV73 | Q68D86 | 1 | relocalization | up-regulates activity | 0.2 | CCDC102B is recruited to the centrosome by C-Nap1 (also known as CEP250) and interacts with the centrosome linker components rootletin and LRRC45. CCDC102B decorates and facilitates the formation of rootletin filaments. Furthermore, CCDC102B is phosphorylated by Nek2A (an isoform encoded by NEK2) and is disassociated f... | SIGNOR-275625 |
P48163 | Q96HS1 | 0 | dephosphorylation | up-regulates activity | 0.2 | PGAM5-mediated dephosphorylation of malic enzyme 1 (ME1) at S336 allows increased ACAT1-mediated K337 acetylation, leading to ME1 dimerization and activation, both of which are reversed by NEK1 kinase-mediated S336 phosphorylation. SIRT6 deacetylase antagonizes ACAT1 function in a manner that involves mutually exclusiv... | SIGNOR-275569 |
P05771 | P11388 | 1 | phosphorylation | up-regulates activity | 0.359 | Here, we have shown that the enzymatic activity of topoisomerase II alpha protein purified from HeLa cell nuclei was strongly enhanced following phosphorylation by protein kinase C. | Site-directed mutagenesis studies indicated that phosphorylation of serine 29 generated both of these phosphopeptides. | SIGNOR-249195 |
P63000 | Q53QZ3 | 0 | gtpase-activating protein | down-regulates activity | 0.581 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260470 |
P13611 | P04637 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.29 | By using in vitro and in vivo assays, we showed CSPG2 to be directly transactivated by p53. | SIGNOR-255441 |
Q13002 | O60260 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | Parkin interacts with and ubiquitinates the GluK2 KAR subunit and regulates GluK2 levels and KAR currents.|The loss of parkin function increases surface and total GluK2 levels, and consistently increases KAR currents. | SIGNOR-278541 |
Q9Y5Z0 | P05067 | 1 | cleavage | up-regulates activity | 0.544 | BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.|Figure 6 Preferred BACE1 and BACE2 cleavage sites. (A) Sequence of APP indicating α- and β-cleavage sites, BACE1- and BACE2-cleavage sites, and the location of mutations analyzed here. ... | SIGNOR-261773 |
Q99814 | Q9H3R0 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | To this end, we confirm that KDM3A, KDM4B, KDM4C, KDM5B, KDM5C, and KDM62 are direct targets of HIF-1a while extent the list of known targets to KDM2A, KDM2B, KDM4D, KDM5A, and KDM6A. The results demonstrated that majority of the KDMs were similarly induced (KDM2A, KDM2B, KDM3A, KDM4B, KDM4C, KDM4D, KDM5A, KDM5B, KDM5C... | SIGNOR-271585 |
P36956 | P17676 | 0 | transcriptional regulation | up-regulates quantity | 0.41 | These results show that GSK3β is involved in regulating phosphorylation and activation of C/EBPβ and that this transcription factor is required to transactivate srebf1a expression, leading to the early steps of adipogenesis | SIGNOR-251645 |
Q9C0C9 | O43541 | 1 | ubiquitination | down-regulates | 0.464 | We showed that ube2o functions as an e2-e3 hybrid to monoubiquitinate smad6 at lysine 174 | SIGNOR-192255 |
P68400 | O14737 | 1 | phosphorylation | up-regulates | 0.2 | Programmed cell death 5 (pdcd5), a protein involved in cell death and down-regulated in different forms of human tumors. Pdcd5 is phosphorylated in vitro by both ck2alpha subunit and by the ck2 holoenzyme at a residue, s118, which is found phosphorylated in vivo. Transfection of the non-phosphorylatable mutant (s118a) ... | SIGNOR-187106 |
Q14934 | P27361 | 0 | phosphorylation | up-regulates | 0.289 | The formation of rsk-nfatc4-dna transcription complex is also apparent upon adipogenesis. Bound rsk phosphorylates ser(676) and potentiates nfatc4 dna binding by escalating nfat-dna association. Ser(676) is also targeted by the erk map kinase, which interacts with nfat at a distinct region than rsk. Thus, integration o... | SIGNOR-133276 |
Q9NYY3 | Q969H0 | 1 | phosphorylation | down-regulates | 0.483 | Plk2 regulates centriole duplication through phosphorylation-mediated degradation of fbxw7 (human cdc4).Plk2 phosphorylates fbxw7 on serine 176 | SIGNOR-196448 |
P08670 | P06493 | 0 | phosphorylation | down-regulates | 0.362 | These results strongly suggest that cdc2 kinase is the kinase which phosphorylates vimentin ser55 in the entire cytoplasm during mitosis and that the appearance of immunoreactivities with antibody 4a4 in cell staining indeed reflect the vimentin phosphorylation by cdc2 kinase. immunofluorescent evidence using antibody... | SIGNOR-35492 |
O60674 | Q12913 | 0 | dephosphorylation | down-regulates activity | 0.323 | These results support PTPRJ preferentially dephosphorylating Y813 and Y868 in JAK2.|We revealed that PTPRJ negatively regulates leptin signaling by dephosphorylating specific tyrosine residues (Y813 and Y868) in JAK2, the simultaneous phosphorylation of which plays a pivotal role in JAK2 activation. | SIGNOR-277094 |
O14672 | P26378 | 0 | post transcriptional regulation | up-regulates quantity | 0.2 | Neuronal ELAV (nELAV) proteins are RNA-binding proteins which play a physiological role in controlling gene expression in memory formation, and their alteration may contribute to cognitive impairment associated with neurodegenerative pathologies such as Alzheimer's disease (AD). The experiments show for the first time ... | SIGNOR-266865 |
P11802 | P19532 | 1 | phosphorylation | up-regulates activity | 0.2 | CDK4 and CDK6 interact with TFEB and TFE3 in the nucleus We next investigated how CDK4 and CDK6 activate TFEB and TFE3 .|We found that CDK4 and CDK6 interact with and phosphorylate nuclear TFEB and TFE3, thereby promoting their shuttling to the cytoplasm. | SIGNOR-279514 |
O75385 | Q15437 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.2 | Here, we show that the F-box protein FBXW5 targets SEC23B, a component of COPII, for proteasomal degradation and that this event limits the autophagic flux in the presence of nutrients. In response to starvation, ULK1 phosphorylates SEC23B on Serine 186, preventing the interaction of SEC23B with FBXW5 and, therefore, i... | SIGNOR-265285 |
Q13501 | Q9UHD2 | 0 | phosphorylation | up-regulates | 0.709 | Tbk-1 coordinated assembly and function of the autophagic machinery and phosphorylated the autophagic adaptor p62 (sequestosome 1) on ser-403, a residue essential for its role in autophagic clearance. | SIGNOR-191944 |
P08235 | P28482 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.286 | Taken together, these data suggest that ERK1/2 directly phosphorylates the MR on several serine residues present in its NTD, that the upward shift of MR is mainly due to receptor phosphorylation, and finally that these sites represent the major aldosterone-inducible targets for MR phosphorylation.MR phosphorylation li... | SIGNOR-276101 |
Q14457 | O75385 | 0 | phosphorylation | up-regulates activity | 0.771 | In the nucleation step of autophagy, The ULK1 complex phosphorylates and activates the Beclin-1-VPS34 complex. | SIGNOR-278503 |
P45983 | P04637 | 1 | phosphorylation | up-regulates | 0.796 | Activated jnk phosphorylates p53 | SIGNOR-59812 |
P35368 | P17252 | 0 | phosphorylation | down-regulates activity | 0.39 | Phorbol ester-induced phosphorylation of the Ser394 and Ser400 as well as GRK2-mediated phosphorylation of the Ser404, Ser408, and Ser410, resulted in the desensitization of alpha1BAR-mediated inositol phosphate response. | SIGNOR-248988 |
P61244 | P68400 | 0 | phosphorylation | down-regulates | 0.361 | Here, we have mapped the nh2-terminal in vivo phosphorylation sites of max to ser2 and ser11[...] | SIGNOR-35772 |
P04004 | P05129 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.285 | Phosphorylation of vitronectin on Ser362 by protein kinase C attenuates its cleavage by plasmin. | SIGNOR-248964 |
P40763 | Q99558 | 0 | phosphorylation | up-regulates activity | 0.26 | Activation of Stat3 by NIK requires NIK kinase activity as showed by kinase assays.|When we transfected NIK into LNCaP cells, NIK was able to phosphorylate Stat3 at both tyrosine 705 and serine 727 residues ( Fig. 3 A). | SIGNOR-279341 |
P52655 | P19784 | 0 | phosphorylation | up-regulates activity | 0.374 | We now show that human TFIIA is phosphorylated in vivo on serine residues that are partially conserved between yeast and human TFIIA large subunits. Alanine substitution mutation of serine residues 316 and 321 in TFIIA alphabeta reduced TFIIA phosphorylation significantly in vivo. Additional alanine substitutions at se... | SIGNOR-250996 |
O14980 | Q13485 | 1 | relocalization | down-regulates | 0.3 | We demonstrate that inhibition of crm1-mediated nuclear export by treatment of cells with leptomycin b results in endogenous smad4 accumulating very rapidly in the nucleus. | SIGNOR-84247 |
P12931 | P49789 | 1 | phosphorylation | up-regulates activity | 0.466 | The human tumor suppressor Fhit is a homodimeric histidine triad (HIT) protein of 147 amino acids which has Ap3A hydrolase activity. We have recently discovered that Fhit is phosphorylated in vivo and is phosphorylated in vitro by Src kinaseMALDI-TOF and HPLC-ESI tandem mass spectrometry of intact Fhit and proteolytic ... | SIGNOR-247134 |
O95295 | P17612 | 0 | phosphorylation | up-regulates activity | 0.307 | PKA-phosphorylation of Snapin significantly increases its binding to synaptosomal-associated protein-25 (SNAP-25). Mutation of Snapin serine 50 to aspartic acid (S50D) mimics this effect of PKA phosphorylation | SIGNOR-250053 |
P43354 | Q13164 | 0 | phosphorylation | up-regulates activity | 0.2 | Activation of MEK, which in turns activates ERK5, does enhance the ERK5 induced nurr1 activity, while no increase is observed in the presence of a dn MEK5 or of the unphosphorylated ERK5 AEF, in which amino acids phosphorylated by MEK5 are mutated.|The A/B domain of nurr1 is highly phosphorylated in the presence of ERK... | SIGNOR-279215 |
Q9H1K1 | P42345 | 0 | phosphorylation | up-regulates | 0.2 | Here, we demonstrate that mtorc1 associates with iscu and phosphorylates iscu at serine 14. This phosphorylation stabilized iscu protein. | SIGNOR-201595 |
Q09472 | P31749 | 0 | phosphorylation | up-regulates | 0.697 | We find that suberoylanilide hydroxamic acid stimulates akt activity, which is required to phosphorylate p300 at ser(1834). Akt-mediated phosphorylation of p300 dramatically increases its acetyltransferase activity | SIGNOR-148983 |
Q2M1Z3 | P60953 | 1 | gtpase-activating protein | down-regulates activity | 0.673 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260490 |
P29401 | Q8N531 | 0 | ubiquitination | up-regulates activity | 0.2 | Mechanistically, VRK2 promoted Thr287 phosphorylation of TKT and then recruited FBXL6 to promote TKT ubiquitination and activation. | SIGNOR-277843 |
P27986 | P06239 | 0 | phosphorylation | down-regulates activity | 0.623 | the regulatory p85 subunit of phosphatidylinositol 3-kinase is phosphorylated on tyrosine residues. We report that this phosphorylation event is readily catalyzed by the Abl and Lck protein-tyrosine kinases in vitro, by Bcr-Abl or a catalytically activated Lck-Y505F in co-transfected COS cells. we have mapped a major p... | SIGNOR-251383 |
Q12913 | P36888 | 1 | dephosphorylation | down-regulates activity | 0.49 | Moreover, activated FLT3 could be dephosphorylated by recombinant DEP-1 in vitro.|The data indicate that DEP-1 is negatively regulating FLT3 signaling activity and that its loss may contribute to but is not sufficient for leukemogenic cell transformation. | SIGNOR-277092 |
Q13464 | P60484 | 1 | phosphorylation | up-regulates | 0.656 | In addition, active rhoa is able to stimulate the phospholipid phosphatase activity of pten in human embryonic kidney cells and leukocytes, and this regulation seems to require rhoa's downstream effector, rhoa-associated kinase (rock). together with the observation that individual substitution of ser 229 and thr 223 r... | SIGNOR-134855 |
Q01484 | Q92823 | 0 | relocalization | up-regulates quantity | 0.737 | Neurofascin, L1, NrCAM, NgCAM, and neuroglian are membrane-spanning cell adhesion molecules with conserved cytoplasmic domains that are believed to play important roles in development of the nervous system. This report presents biochemical evidence that the cytoplasmic domains of these molecules associate directly with... | SIGNOR-266719 |
Q9Y4D1 | P12931 | 0 | phosphorylation | up-regulates activity | 0.325 | Our findings reveal a novel mechanism by which reversible tyrosine phosphorylation of DAAM1 by Src and PTPN3 regulates actin dynamics and lung cancer invasiveness.|PTPN3 suppresses lung cancer cell invasiveness by counteracting Src mediated DAAM1 activation and actin polymerization. | SIGNOR-280128 |
P37840 | P53355 | 0 | phosphorylation | up-regulates quantity | 0.27 | We demonstrated that DAPK1 directly phosphorylates \u03b1-synuclein at Ser129, and induces the formation of insoluble \u03b1-synuclein aggregates. | SIGNOR-278440 |
O15530 | Q05513 | 1 | phosphorylation | up-regulates | 0.577 | Our findings suggest that insulin, via pip(3), provokes increases in pkc-zeta enzyme activity through (a) pdk-1-dependent t410 loop phosphorylation, (b) t560 autophosphorylationcytoskeletal reorganization;tnni1(induces);desmin(induces);tpm1(induces);myo1c(induces);tnnt1(induces); | SIGNOR-85501 |
P49841 | Q13144 | 1 | phosphorylation | down-regulates activity | 0.579 | The largest (epsilon) subunit of eIF2B is a substrate for glycogen synthase kinase (GSK)-3 in vitro, and phosphorylation by GSK3 inhibits the activity of eIF2B. The site of phosphorylation has previously been identified as Ser(535). | SIGNOR-251236 |
Q9UHD2 | Q92630 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.413 | We further found that DYRK2 phosphorylated Ser527 of TBK1, which is essential for the recruitment of NLRP4 and for the E3 ubiquitin ligase DTX4 to degrade TBK1. | SIGNOR-276939 |
P15923 | P49137 | 0 | phosphorylation | up-regulates | 0.52 | Neverthless, some transcription factors, such as e47, er81, srf and creb are also phosphorylated by mk2 | SIGNOR-166643 |
Q15418 | P78371 | 1 | phosphorylation | up-regulates | 0.249 | Furthermore, both the s260a and s260d mutants showed a decreased folding capacity as compared to cells expressing the wild-type cct_ subunit ( fig.?_5e), suggesting that a cyclic phosphorylation of the s260 site by s6k1 is likely to be important for chaperonin function and that mutation of this site interferes with thi... | SIGNOR-172986 |
Q14469 | P04150 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.2 | HES1 binding to the promoter of the NC3C1 gene inhibits its expression and results in insufficient production of the encoded glucocorticoid receptor- rendering these cells resistant to treatment with dexamethasone | SIGNOR-251674 |
P67775 | P27361 | 1 | dephosphorylation | down-regulates | 0.647 | P-erk1/2 proteins were efficiently dephosphorylated in vitro by protein phosphatases 1 and 2a (pp1/2a) and mapk phosphatase 3 (mkp3). | SIGNOR-103162 |
Q9HB96 | O14757 | 0 | phosphorylation | up-regulates | 0.716 | Chk1 directly phosphorylates the fance subunit of the fa core complex on two conserved sites (threonine 346 and serine 374). chk1-mediated phosphorylation of fance is required for the fanconi anemia/brca pathway. | SIGNOR-153023 |
Q9H9Z2 | P28482 | 0 | phosphorylation | down-regulates activity | 0.262 | Here we show that Lin28a is directly phosphorylated by ERK1/2 kinases at Ser-200. | SIGNOR-277338 |
O43303 | P24941 | 0 | phosphorylation | down-regulates activity | 0.515 | GST-tagged recombinant CP110 (GST-wt) was robustly phosphorylated by cyclin E/CDK2 (Figure 2A). Expression of a mutant derivative of CP110 refractory to CDK phosphorylation provokes marked polyploidy. We localized the majority (nine of ten) of potential CDK2 phosphorylation sites in CP110 to an amino-terminal fragmen... | SIGNOR-265956 |
P49841 | Q9Y6K9 | 1 | phosphorylation | down-regulates quantity | 0.431 | For analysis of phosphorylation of NEMO on Ser8 and Ser17 by GSK-3, we generated phospho-specific antibodies (anti-phospho-NEMO-Ser8 and anti-phospho-NEMO-Ser17) while anti-phospho-NEMO-Ser31 and anti-phospho-NEMO-Ser43 were commercially available. Indeed, GSK-3\u03b2 was able to phosphorylate all four serines of rhNEM... | SIGNOR-279527 |
P17252 | P15311 | 1 | phosphorylation | up-regulates | 0.547 | Phosphorylation of ezrin is required for both conformational activation and for signaling to downstream events. The activating c-terminal threonine phosphorylation on t567 was first described to be downstream of the rho pathway (matsui et al., 1998). Additional studies have implicated protein kinase c (pkc) in the ph... | SIGNOR-133223 |
P28482 | Q99967 | 1 | phosphorylation | up-regulates activity | 0.454 | CITED2 coactivation is enhanced by activation of MAPK1 and requires T166.|CITED2 is phosphorylated by MAPK1 at S85, T166 and T175. | SIGNOR-278410 |
P28562 | P45983 | 1 | dephosphorylation | down-regulates | 0.789 | Jnk1 phosphorylation and activation was inhibited by expression of both mkp1 and mkp2. | SIGNOR-46079 |
Q00535 | P07197 | 1 | phosphorylation | down-regulates quantity | 0.42 | Converse to the effect of PKA overexpression, overexpression of CDK5 and its activator, p35, decreased the association between spinophilin and NF-M as well as the expression of NF-M.|Moreover, CDK5 phosphorylates NF-M [ xref ], and this was also apparent in our data, given a dramatic molecular weight shift in the NF-M ... | SIGNOR-279683 |
P16104 | O76064 | 0 | ubiquitination | up-regulates | 0.2 | Rnf8 can ubiquitylate histone h2a and h2ax, | SIGNOR-159309 |
Q13882 | P51692 | 1 | phosphorylation | up-regulates | 0.429 | Phosphospecific antibodies, mutational analysis, and in vitro kinase assays demonstrated that brk specifically mediated stat5b phosphorylation at the activating tyrosine, y699. | SIGNOR-159066 |
P24941 | Q01196 | 1 | phosphorylation | up-regulates activity | 0.2 | We have identified four phosphorylation sites on aml1c that are necessary for transcriptional activity of aml1c in k562 and 293t cells (27).4 mutation of these four sites (serine 276, serine 293, serine 303, and threonine 300) to alanine abolishes transcriptional activation, whereas mutation of these sites to aspartic ... | SIGNOR-138932 |
Q12772 | Q8WU17 | 0 | ubiquitination | down-regulates quantity | 0.477 | Induction of TRC8 destabilized the precursor forms of the transcription factors SREBP-1 and SREBP-2. TRC8 destablizes SREBP precursors in a RING and proteasome-dependent manner | SIGNOR-271958 |
P12931 | P10398 | 1 | phosphorylation | up-regulates activity | 0.489 | A-raf behaves like raf-1, being weakly activated by oncogenic ras more strongly activated by oncogenic src, and these signals synergize to give maximal activation | SIGNOR-236459 |
Q96PX1 | P24941 | 0 | phosphorylation | up-regulates activity | 0.287 | CDK2 promotes phosphorylation of RNF157 at the same Ser 660-663 residues that become phosphorylated downstream of combined PI3K and MAPK pathway activity. | SIGNOR-279016 |
Q15208 | P49841 | 0 | phosphorylation | down-regulates activity | 0.278 | GSK-3β phosphorylated STK38 on residues S6 and T7 in vitro, depending largely on a PKA-mediated priming phosphorylation of STK38 on residues S10 and S11, respectively. Our results indicate that that GSK-3β inhibits STK38's full activation, and suggest that STK38 activation is required to prevent cell death in response... | SIGNOR-276392 |
Q8IVT5 | Q7Z569 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.661 | Here we report on a novel interaction between the E3 ligase BRAP (also referred to as IMP), a negative regulator of the MAPK scaffold protein KSR, and two closely related deubiquitylases, USP15 and USP4. USP15 as well as USP4 oppose the autoubiquitylation of BRAP, whereas BRAP promotes the ubiquitylation of USP15. | SIGNOR-272028 |
P41229 | P78317 | 0 | sumoylation | up-regulates activity | 0.2 | Hendriks and coworkers showed that, in response to alkylation damage by methyl methanesulfonate (MMS), SUMOylated JARID1B (KDM5B) is ubiquitylated by the SUMOtargeted ubiquitin ligase RNF4 and degraded by the proteasome, whereas JARID1C (KDM5C) is SUMOylated and recruited to the chromatin to demethylate histone H3K4 (H... | SIGNOR-271576 |
Q9NZ42 | P49768 | 1 | cleavage | up-regulates | 0.959 | Our data reveal a direct role of pen-2 in proteolytic cleavage of ps1 and a regulatory function of aph-1, in coordination with pen-2, in the biogenesis of the ps1 complex. | SIGNOR-97113 |
Q16549 | P30305 | 1 | phosphorylation | down-regulates | 0.2 | We propose that regulation of cdc25b phosphorylation by p38 is a critical event for initiating the g2/m checkpoint after ultraviolet radiation | SIGNOR-107423 |
P24941 | P25205 | 1 | phosphorylation | up-regulates | 0.796 | In this study, we demonstrate that mcm3 is a substrate of cyclin e/cdk2 and can be phosphorylated by cyclin e/cdk2 at thr-722. | SIGNOR-176656 |
Q99962 | O75116 | 0 | phosphorylation | down-regulates | 0.439 | We identified the phosphorylation site of endophilin a1 at thr-14 endophilin t14d inhibited egf receptor internalization. Furthermore, phosphorylation of endophilin by rho-kinase inhibited the binding to cin85. | SIGNOR-140466 |
Q16537 | Q9P2K6 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.2 | PPP2R5ϵ is a KLHL42 substrate and affects TGF-β signaling in SSc. Lys-84 is a candidate ubiquitin acceptor site within PPP2R5ϵ. | SIGNOR-272205 |
O75592 | P49815 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.356 | We show that Pam associates with E2 ubiquitin conjugating enzymes, and tuberin can be ubiquitinated by Pam through its RING finger domain. | SIGNOR-278704 |
P16885 | P43405 | 0 | phosphorylation | up-regulates activity | 0.753 | Syk in turn phosphorylates and activates the B cell linker protein (BLNK), phosphoinositide 3-kinase (PI3K) and phospholipase C\u03b32 (PLC\u03b32).|Syk in turn phosphorylates and activates the B cell linker protein (BLNK), phosphoinositide 3-kinase (PI3K) and phospholipase Cgamma2 (PLCgamma2). | SIGNOR-278995 |
P62714 | P05771-2 | 1 | dephosphorylation | down-regulates activity | 0.469 | Specifically, the threonine at position 500 (T500) on the activation loop, and T641 and S660 on the carboxyl terminus of protein kinase C beta II are phosphorylated in vivo. T500 and S660 are selectively dephosphorylated in vitro by protein phosphatase 2A to yield an enzyme that is still capable of lipid-dependent acti... | SIGNOR-248587 |
P49760 | Q9UBK2 | 1 | phosphorylation | down-regulates activity | 0.2 | Clk2 could also repress PGC-1alpha activation of Foxo1 on the IRS response element , as well as repress the Pepck promoter .|Clk2 phosphorylates and represses PGC-1\u03b1. | SIGNOR-278228 |
P06493 | Q12778 | 1 | phosphorylation | down-regulates | 0.511 | Overexpression of cdk1 inhibits the transcriptional activity of foxo1 in pca cells through s249 phosphorylation on foxo1. | SIGNOR-178202 |
Q05513 | Q5JVS0 | 1 | phosphorylation | down-regulates activity | 0.292 | We found a strong phosphorylation of Ki-1/57 by PKCalphabeta, PKCdelta, PKClambda/zeta, and especially by PKCsigma, however not by PKCmi. These data show that Ki-1/57 can serve in principal as a substrate for a wide variety of different PKC isoforms but also that its phosphorylation is strongest with PKCsigma. | This s... | SIGNOR-249257 |
P29466 | P49768 | 1 | cleavage | up-regulates activity | 0.385 | Remarkably, the caspases acting on PS1 could be subdivided in two groups. One group, containing caspase-8, -6 and -11, cleaved PS1 after residues ENDD329 and to a lesser extent after residues AQRD341. A second group consisting of caspase-3, -7 and -1 acted uniquely on AQRD341. Importantly, these two cleavage sites were... | SIGNOR-261755 |
P02458 | P03956 | 0 | cleavage | down-regulates quantity by destabilization | 0.445 | MMP-1 cleaves type II collagen at the peptide bond Gly906-Leu907 Proteolysis of triple-helical collagen is an important step in the progression toward irreversible tissue damage in osteoarthritis. Earlier work on the expression of enzymes in cartilage suggested that collagenase-1 (MMP-1) contributes to the process. | SIGNOR-256341 |
P49407 | P27361 | 0 | phosphorylation | down-regulates | 0.716 | Erk1 and erk2 phosphorylate beta-arrestin1 at ser-412 in vitro. . in the resting state, cytosolic arrestin1 proteins are constitutively phosphorylated by extracellular signal-regulated kinase (erk) at ser412, located within their distal c terminus. erk-phosphorylated arrestin1 is unable to associate with clathrin cages... | SIGNOR-67634 |
P09668 | P02818 | 1 | cleavage | down-regulates quantity by destabilization | 0.283 | This study has been undertaken to compare the degradation of BGP by the cysteine proteinases cathepsins L, B, H, S, and the aspartic proteinase cathepsin D. Cathepsins B, L, H, and S readily cleave BGP at the G7-A8 bond; cathepsin L also cleaves at R43-R44; cathepsin B also cleaves at R44-F45; and cathepsin D cleaves o... | SIGNOR-256325 |
Q16566 | Q9UNW9 | 1 | phosphorylation | up-regulates quantity | 0.255 | CaMKIV Phosphorylates Nova-2 and Regulates Its Nuclear Localization. CaMKIV Phosphorylates Nova-2 and Regulates Its Nuclear Localization. Conversely, Nova-2 with single or double mutations to alanine (2A and 1A2A) was predominantly nuclear, like the WT (Figures 5H and and5I).5I). In contrast, glutamate mutations at s... | SIGNOR-273521 |
Q14643 | Q96K19 | 0 | polyubiquitination | down-regulates activity | 0.431 | In summary, here we present evidence that RNF170 is an E3 ligase that mediates IP3 receptor ubiquitination and processing by the UPP and that it is recruited to activated IP3 receptors by the erlin1/2 complex to which it is constitutively bound. | SIGNOR-271913 |
O75116 | Q9UBR4 | 1 | phosphorylation | up-regulates activity | 0.2 | Rok-\u03b1 phosphorylates and activates LIM kinase, which in turn phosphorylates and inactivates cofilin. | SIGNOR-280110 |
O15350 | Q05655 | 0 | phosphorylation | up-regulates | 0.307 | The results show that pkcdeltacf phosphorylates the p73beta transactivation and dna-binding domains. pkcdeltacf-mediated phosphorylation of p73beta is associated with accumulation of p73beta and induction of p73beta-mediated transactivation. | SIGNOR-90279 |
Q9Y4I1 | P31751 | 0 | phosphorylation | up-regulates activity | 0.458 | Here we identify an Akt consensus phosphorylation motif in the actin-based motor protein myosin 5a and show that insulin stimulation leads to phosphorylation of myosin 5a at serine 1650. This Akt-mediated phosphorylation event enhances the ability of myosin 5a to interact with the actin cytoskeleton.Taken together, the... | SIGNOR-262632 |
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