IdA string | IdB string | labels int64 | mechanism string | effect string | score float64 | sentence string | signor_id string |
|---|---|---|---|---|---|---|---|
P17252 | P23677 | 1 | null | down-regulates activity | 0.37 | In contrast, phosphorylation of the A isoform with PKC caused a significant decrease in activity whether assayed in the presence or absence of calcium/calmodulin (to _25% of the unphosphorylated enzyme activity). | SIGNOR-248991 |
P04406 | Q5XX13 | 0 | polyubiquitination | up-regulates activity | 0.2 | Mechanistically, FBXW10 promotes GAPDH polyubiquitination and activation; VRK2-dependent phosphorylation of GAPDH Ser151 residue is critical for GAPDH ubiquitination and activation. | SIGNOR-277841 |
Q13547 | P19784 | 0 | phosphorylation | up-regulates activity | 0.398 | Human HDAC1 protein was analyzed by ion trap mass spectrometry, and two phosphorylated serine residues, Ser(421) and Ser(423), were unambiguously identified. Loss of phosphorylation at Ser(421) and Ser(423) due to mutation to alanine or disruption of the casein kinase 2 consensus sequence directing phosphorylation redu... | SIGNOR-250999 |
P32121 | Q02750 | 0 | phosphorylation | up-regulates activity | 0.587 | Here, we show that activation of serotonin 5-HT2C receptors, which engage Erk1/2 pathway via a _-arrestin-dependent mechanism, promotes MEK-dependent _-arrestin2 phosphorylation at Thr383 | SIGNOR-252027 |
P35568 | P17612 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.2 | Tyrosine phosphorylation of IRS-1 initiates insulin signaling, whereas serine/threonine phosphorylation alters the ability of IRS-1 to transduce the insulin signalInsulin increased the phosphorylation of Ser312, Ser616, Ser636, Ser892, Ser1101, and Ser1223 | SIGNOR-235675 |
O15530 | P05129 | 1 | phosphorylation | up-regulates | 0.2 | One of the most studiedevents controlled by ptdins(3,4,5)p3, comprises the activation of aof agc family protein kinases, including isoforms of protein kinase b (pkb)/akt, p70 ribosomal s6 kinase (s6k), serum- and glucocorticoid-induced protein kinase (sgk) and protein kinase c (pkc), which play crucial roles in regulat... | SIGNOR-126072 |
Q92945 | P12931 | 1 | post transcriptional regulation | up-regulates quantity by expression | 0.271 | We show here that this component of the DCS complex is hnRNP H and that, like hnRNP F and KSRP, hnRNP H is needed for src N1 splicing in vitro. | SIGNOR-261274 |
Q9UJU2 | Q8WVD3 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.307 | Here, we show that NARF induces the ubiquitylation of TCF/LEF in vitro and in vivo, and functions as an E3 ubiquitin-ligase that specifically cooperates with the E2 conjugating enzyme E2-25K. We found that NLK augmented NARF binding and ubiquitylation of TCF/LEF, and this required NLK kinase activity. The ubiquitylated... | SIGNOR-271595 |
Q8IX90 | P06493 | 0 | phosphorylation | up-regulates activity | 0.394 | Cdk1 treatment further enhanced the binding of Ska3 2D to Ndc80, suggesting that phosphorylation of other Cdk1 sites in Ska3 further contributes to the Ndc80C-Ska3 interaction, although this contribution is not apparent in our kinetochore localization assay.We next purified the GST-Ndc80C Bonsai construct that lacks th... | SIGNOR-278376 |
P24941 | P23771 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.362 | Phosphorylation of GATA3 Thr-156 was detected in mouse thymocytes, and cyclin-dependent kinase 2 (CDK2) was identified as a respondent for phosphorylation at Thr-156. | SIGNOR-276634 |
Q15910 | Q9Y297 | 0 | ubiquitination | down-regulates | 0.376 | _-trcp ubiquitinates ezh2 and jak2-mediated phosphorylation on y641 directs _-trcp-mediated ezh2 degradation. | SIGNOR-204481 |
Q9UQ80 | P19525 | 0 | phosphorylation | up-regulates activity | 0.243 | Ebp1 itself is phosphorylated by the PKR protein kinase, suggesting that the effects of Ebp1 overexpression evidenced in vivo on eIF2alpha phosphorylation could be achieved by competition between Ebp1 and eIF2alpha for PKR kinase activity. | SIGNOR-279170 |
P28329 | Q9UQM7 | 0 | phosphorylation | up-regulates | 0.372 | We show that chat is differentially phosphorylated by protein kinase c (pkc) isoforms on four serines (ser-440, ser-346, ser-347, and ser-476) and one threonine (thr-255). This phosphorylation is hierarchical, with phosphorylation at ser-476 required for phosphorylation at other serines. Phosphorylation at some, but no... | SIGNOR-96628 |
O14867 | Q8NEZ5 | 0 | ubiquitination | down-regulates quantity | 0.282 | Here, we show that heme triggers the degradation of Bach1, a pro-metastatic transcription factor, by promoting its interaction with the ubiquitin ligase Fbxo22. | SIGNOR-259331 |
P61586 | Q12774 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.617 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260533 |
P28482 | Q86UR1 | 1 | phosphorylation | down-regulates | 0.326 | These results demonstrated a critical role of noxa1 phosphorylation on ser-282 and ser-172 in preventing nox1 hyperactivation through the decrease of noxa1 interaction to nox1 and rac1. | SIGNOR-163659 |
Q99836 | P12931 | 0 | phosphorylation | up-regulates activity | 0.445 | Because MyD88 was phosphorylated at the tyrosine 58 residue in hemi-ITAM by LPS ( xref ), whether Src phosphorylates MyD88 at the tyrosine 58 residue was examined further, and MyD88 was phosphorylated by Src at Y58 ( xref ).|Src activates MyD88 by phosphorylation at Y58 via the Src kinase domain. | SIGNOR-279655 |
P11498 | Q16654 | 0 | phosphorylation | down-regulates activity | 0.373 | PDK4 phosphorylates and inhibits the pyruvate dehydrogenase complex (PDC) which catalyzes the conversion of pyruvate to acetyl-CoA in the glucose oxidation pathway. | SIGNOR-278974 |
P62877 | P03372 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.344 | I3C-dependent activation of the aryl hydrocarbon receptor (AhR) initiates Rbx-1 E3 ligase-mediated ubiquitination and proteasomal degradation of ERalpha protein. | SIGNOR-271434 |
Q13188 | Q9H2K8 | 0 | phosphorylation | up-regulates | 0.291 | In addition, the thousand-and-one (tao) amino acids kinase or taok1 3 has been shown to directly phosphorylate and activate hpo or mst1/2 | SIGNOR-201333 |
Q13153 | Q96P20 | 1 | phosphorylation | up-regulates activity | 0.2 | Pak1 phosphorylates NLRP3 to promote inflammasome activation. | SIGNOR-277547 |
P07332 | P15311 | 0 | relocalization | up-regulates | 0.395 | The recruitment and the activation of fes to the cell-cell contacts in confluent cells depend on its interaction with ezrin. | SIGNOR-159496 |
Q92696 | P20336 | 1 | lipidation | up-regulates activity | 0.569 | Prenylation (or geranylgeranylation) of Rab GTPases is catalysed by RGGT (Rab geranylgeranyl transferase) and requires REP (Rab escort protein). In the classical pathway, REP associates first with unprenylated Rab, which is then prenylated by RGGT. In the alternative pathway, REP associates first with RGGT; this compl... | SIGNOR-265574 |
P00519 | O60504 | 1 | phosphorylation | up-regulates activity | 0.412 | Abl kinase interacts with and phosphorylates vinexin. | SIGNOR-280172 |
Q96GD4 | Q9NP77 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.254 | Here we report that Aurora B kinase directly interacts with and phosphorylates Ssu72, a new cohesin-binding phosphatase, at Ser 19 in vitro and in vivo. The Aurora B-mediated phosphorylation of Ssu72 causes the structural modification of Ssu72 protein, downregulates phosphatase activity and triggers the ubiquitin-depen... | SIGNOR-275529 |
Q04206 | P05231 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.692 | Recent reports show that in mice the microbiome, comprising commensal microorganisms that colonize body surfaces, promotes a partial and low-grade M1-like phenotype in macrophages throughout the body, including those in lymphoid organs (119, 120). This M1-like priming of macrophages induces chromatin remodeling with in... | SIGNOR-251737 |
P05067 | Q9Y5Z0 | 0 | cleavage | up-regulates activity | 0.544 | BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.|Figure 6 Preferred BACE1 and BACE2 cleavage sites. (A) Sequence of APP indicating α- and β-cleavage sites, BACE1- and BACE2-cleavage sites, and the location of mutations analyzed here. ... | SIGNOR-261773 |
O75061 | P11142 | 1 | relocalization | up-regulates activity | 0.883 | Hsc70, recruited by the J-domain protein auxilin, mediates clathrin uncoating and release of a free vesicle, primed to fuse with a target membrane. | SIGNOR-260719 |
P35580 | Q05513 | 0 | phosphorylation | down-regulates | 0.269 | After egf stimulation, apkc_ translocates from the nucleus to the cytoplasm (figure 3) and is therefore able to interact with myosin ii-b. apkc_ phosphorylates nmhc ii-b on ser1937, which is located on the nonhelical tailpiece, leading to filament disassembly at certain sites of the cell | SIGNOR-146100 |
P07948 | Q12972 | 1 | phosphorylation | down-regulates activity | 0.312 | Tyrosine phosphorylation of NIPP1 by Lyn was abolished by the Tyr-264 to Asp mutation. | SIGNOR-251405 |
P49841 | Q15853 | 1 | phosphorylation | up-regulates activity | 0.283 | Although no study has yet correlated the activity of GSK3beta with the activity of USF2 in a certain tumor setting, the findings of the present study would favor the tumor promoting aspects of GSK3beta and USF2 since GSK3beta activated USF2 enhanced cell migration which may be important in terms of tumor cell metastasi... | SIGNOR-278158 |
P23458 | P38484 | 1 | phosphorylation | up-regulates activity | 0.66 | The activation of this signaling pathway involves the binding of IFN-g to two IFN-g receptor (IFN-gR) subunits, made up of respective IFNgR1:IFNgR2 pairs, which dimerize upon IFN-g binding to form the IFN-gR complex. Two JAKs, JAK1and JAK2,which bind to each IFN-gR subunits, respectively through their N-terminal domain... | SIGNOR-249491 |
P01112 | P21359 | 0 | gtpase-activating protein | down-regulates activity | 0.813 | Nf1encodes neurofibromin, a protein with multiple functions including ras inactivation (ras gtpase-activating protein or rasgap) and adenylyl cyclase (ac) activation | SIGNOR-204357 |
Q15759 | P15336 | 1 | phosphorylation | up-regulates | 0.756 | Our results indicate that atf-2 not only directly binds to smad3/4 hetero-oligomers but also that atf-2 is phosphorylated by tgf-beta signaling via tak1 and p38. The two pathways, smad and tak1, synergistically enhance the activity of atf-2 which acts as their common nuclear target | SIGNOR-65586 |
O15519 | Q96J02 | 0 | ubiquitination | down-regulates quantity | 0.614 | Depends on JNK-mediated phosphorylation and activation of the E3 ubiquitin ligase Itch, which specifically ubiquitinates c-FLIP and induces its proteasomal degradation. | SIGNOR-245307 |
P48730 | Q9Y6Q9 | 1 | phosphorylation | up-regulates | 0.284 | In this study, we show that both eralpha and aib1 are substrates for ck1delta in vitro, and identify a novel aib1 phosphorylation site (s601) targeted by ck1delta, significant for the co-activator function of aib1. | SIGNOR-184946 |
Q8IVT5 | P27448 | 0 | phosphorylation | down-regulates activity | 0.642 | C-TAK1 phosphorylates KSR1 at S392, forming a 14-3-3 binding site.|In mammalian cells, C-TAK1 has been shown to negatively regulate KSR1 by phosphorylation of Ser392. | SIGNOR-279225 |
Q92993 | Q13315 | 1 | acetylation | up-regulates activity | 0.8 | Here, we report that sirtuin 7 (SIRT7)-mediated deacetylation is essential for dephosphorylation and deactivation of ATM. We show that SIRT7, a class III histone deacetylase, interacts with and deacetylates ATM in vitro and in vivo. |Upon DNA damage, ATM is activated via a series of highly organized machineries, includ... | SIGNOR-275891 |
P63000 | Q8IYU2 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.367 | The CNF1 toxin of pathogenic Escherichia coli addresses Rac1 to ubiquitin-proteasome system (UPS). We report the essential role of the tumor suppressor HACE1, a HECT-domain containing E3 ubiquitin-ligase, in the targeting of Rac1 to UPS. HACE1 binds preferentially GTP-bound Rac1 and catalyzes its polyubiquitylation | SIGNOR-255538 |
P42771 | Q8IXJ9 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.3 | Modeling ASXL1 mutation revealed impaired hematopoiesis caused by derepression of p16Ink4a through aberrant PRC1-mediated histone modification. These results indicated that loss of protein interaction between Asxl1 mutant and Bmi1 affected the activity of PRC1, and subsequent derepression of p16Ink4a by aberrant histon... | SIGNOR-260119 |
P28482 | Q07343 | 1 | phosphorylation | up-regulates activity | 0.268 | The short-form PDE4B2 isoenzyme was activated by Erk2 phosphorylation. These functional changes in PDE activity were mimicked by mutation of the target serine for Erk2 phosphorylation to the negatively charged amino acid, aspartic acid. | SIGNOR-275970 |
O75925 | O15111 | 0 | phosphorylation | up-regulates activity | 0.38 | In addition, we show that IKKalpha is associated with PIAS1 and mediates the S90 phosphorylation of PIAS1.|Mutational studies indicate that Ser90 phosphorylation is required for PIAS1 to repress transcription. | SIGNOR-278926 |
P61586 | Q2M1Z3 | 0 | gtpase-activating protein | down-regulates activity | 0.529 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260488 |
P35318 | P05549 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.267 | These findings suggest that NF-IL6 and AP-2 sites in the promoter region are the functional elements in the transcriptional regulation of human AM gene in vascular endothelial cells. | SIGNOR-254048 |
Q13233 | P45985 | 1 | phosphorylation | up-regulates activity | 0.729 | The gck-ctd-mekk1 interaction is sufficiently stable to support mekk1 s phosphorylation of its substrate, sek1 | SIGNOR-236380 |
Q15831 | Q9H093 | 1 | phosphorylation | up-regulates | 0.273 | A total of 12 human kinases (nuak1, nuak2, brsk1, brsk2, qik, qsk, sik, mark1, mark2, mark3, mark4 and melk) are related to ampk. Here we demonstrate that lkb1 can phosphorylate the t-loop of all the members of this subfamily, apart from melk, increasing their activity >50-fold. | SIGNOR-122717 |
Q14258 | P06744 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.25 | Gp78 is a ubiquitin ligase that plays a vital role in endoplasmic reticulum (ER)-associated degradation (ERAD). Here we report that autocrine motility factor (AMF), also known as phosphoglucose isomerase (PGI), is a novel substrate of gp78. We show that polyubiquitylation of AMF requires cooperative interaction between... | SIGNOR-272178 |
P10636 | Q96L34 | 0 | phosphorylation | down-regulates activity | 0.419 | AMPK phosphorylation inhibits tau binding of microtubules. In order to study further the phosphorylation of tau by AMPK, we compared phosphorylation of tau by MARK4 or AMPK using a panel of phospho-tau antibodies (Figure 2A). Five phosphorylation sites common to both kinases were identified (Thr231, Ser262, Ser356, Ser... | SIGNOR-273935 |
P46108 | P52564 | 0 | phosphorylation | up-regulates | 0.2 | Mapkk6 was shown to phosphorylate and specifically activate the p38/mpk2 sub-family of the mitogen-activated protein kinase superfamily. | SIGNOR-42384 |
Q9Y6D6 | P17612 | 0 | phosphorylation | up-regulates activity | 0.2 | Within 20 min after addition of 8-Br-cAMP, BIG1 accumulated in nuclei, and this effect was blocked by protein kinase A (PKA) inhibitors H-89 and PKI, suggesting a dependence on PKA-catalyzed phosphorylation. |Mutant BIG1 (S883A) in which Ala replaced Ser-883, a putative PKA phosphorylation site, did not move to the nuc... | SIGNOR-272146 |
Q15910 | Q16539 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.372 | Here, we show that p38α kinase promotes EZH2 degradation in differentiating muscle cells through phosphorylation of threonine 372 | SIGNOR-255663 |
O60281 | P01241 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | Rat Zn-15 is a transcription factor activating GH gene expression by synergistic interactions with Pit-1, named for 15 DNA-binding zinc fingers, including fingers IX, X, and XI that are responsible for GH promoter binding. | SIGNOR-268969 |
A0A1B0GVQ0 | Q00535 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.2 | Cdk5 also phosphorylates PSD-95-interacting protein Spine Associated RapGAP (SPAR), resulting in its degradation ([98], Table 2). | SIGNOR-280219 |
P57078 | Q13489 | 0 | polyubiquitination | up-regulates activity | 0.355 | CIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).Together, our results demonstrate that depleting cIAP1/2 inhibits RIP1-4 mediated NF-kB activation without affecting RIP auto-phosphorylation.Lysine residues K51 and K145 of RIP4 are crit... | SIGNOR-272709 |
Q9H3M7 | P28482 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.294 | ERK-dependent Txnip ubiquitination and proteasome degradation depended upon phosphorylation of a PXTP motif threonine (Thr349) located within the C-terminal α-arrestin domain and proximal to a previously characterized E3 ubiquitin ligase-binding site. | SIGNOR-277468 |
P63000 | Q9NRY4 | 0 | gtpase-activating protein | down-regulates activity | 0.724 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260493 |
P01222 | Q92911 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.38 | I– uptake is stimulated by TSH, the master hormone for thyroid gland regulation. TSH stimulation results, at least in part, from the cAMP-mediated increase in NIS biosynthesis. TSH not only stimulates NIS transcription and biosynthesis but is also required for modulating the NIS phosphorylation pattern, maintaining i... | SIGNOR-251995 |
P60484 | Q9UHC7 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.43 | EGFR/PI3K/AKT-mediated ubiquitination and degradation of PTEN are dependent on the MKRN1 E3 ligase.|In fact, epidermal growth factor-stimulated pAKT phosphorylates and subsequently stabilizes MKRN1, which then ubiquitinates and induces the degradation of PTEN. | SIGNOR-278830 |
Q9NZ42 | P34925 | 1 | cleavage | up-regulates | 0.2 | Ryk activity is modulated through cleavage of its icd by gamma-secretase | SIGNOR-182145 |
P61586 | O94827 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.771 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260566 |
Q9Y297 | Q13131 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.2 | Glucose deprivation activates AMPK kinase to phosphorylate β-TrCP1 and promotes the subsequent ubiquitination and degradation of β-TrCP1 by β-TrCP2, but does not promote β-TrCP2 degradation by β-TrCP1. | SIGNOR-277475 |
P19484 | P00519 | 0 | phosphorylation | down-regulates activity | 0.2 | Our data show that c-Abl promotes TFEB tyrosine phosphorylation and that its inhibition induces TFEB activity.|c-Abl Inhibition Activates TFEB and Promotes Cellular Clearance in a Lysosomal Disorder Summary The transcription factor EB ( TFEB ) has emerged as a master regulator of lysosomal biogenesis , exocytosis , and... | SIGNOR-279583 |
P61586 | A1A4S6 | 0 | gtpase-activating protein | down-regulates activity | 0.668 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260465 |
P50613 | P24928 | 1 | phosphorylation | down-regulates | 0.789 | Although there is some inconsistency in the literature, it is generally thought that cdk7, a component of the transcription factor (tf) iih, is a major ser-5 kinase, whereas cdk9, a component of positive transcription elongation factor (p-tef) b, is a major ser-2 kinase within cells. These results suggest that subseque... | SIGNOR-120024 |
Q05397 | A6NI28 | 1 | phosphorylation | up-regulates activity | 0.309 | FAK and Src Mediated Phosphorylation of GRAF3 at Y376 Promotes Allosteric Activation. | SIGNOR-280097 |
O43683 | Q13257 | 1 | relocalization | up-regulates activity | 0.96 | Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity | SIGNOR-252018 |
P13501 | Q9BZS1 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.434 | Given its role as a potent chemoattractant for T cells, CCL5 can be utilized to attract Tregs to malignant epithelial cells. Wang et al. demonstrated that Forkheadbox protein 3 (FOXP3), a key transcription factor for Tregs, was highly ex- pressed in pancreatic cancer cell lines, which, in turn, upregulated CCL5 express... | SIGNOR-277727 |
P69905 | P14384 | 0 | cleavage | down-regulates activity | 0.2 | Both human plasma carboxypeptidase N (CPN) and membrane-bound carboxypeptidase M (CPM) released the C-terminal arginine (alpha-Arg141) of the alpha chain of human adult hemoglobin. Thus, the hydrolysis of hemoglobin by CPM and CPN demonstrated the contribution of the alpha-Arg141 residue to sustaining the tetrameric st... | SIGNOR-256507 |
Q9HAV4 | P28482 | 0 | phosphorylation | down-regulates activity | 0.301 | Here we show that ERK suppresses pre-miRNA export from the nucleus through phosphorylation of exportin-5 (XPO5) at T345/S416/S497. After phosphorylation by ERK, conformation of XPO5 is altered by prolyl isomerase Pin1, resulting in reduction of pre-miRNA loading. | SIGNOR-262984 |
P68400 | P43629 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.2 | Functional studies of the wild-type receptor and serine/threonine mutants indicated that phosphorylation of Ser(394) by protein kinase C slightly suppresses KIR3DL1 inhibitory function, and reduces receptor internalization and turnover.Both CKII and PKC phosphorylate KIR3DL1 in vitro. Ser364 can be phosphorylated after... | SIGNOR-276077 |
P53355 | P12931 | 0 | phosphorylation | down-regulates activity | 0.273 | Here, we show that the leukocyte common antigen-related (LAR) tyrosine phosphatase dephosphorylates DAPK at pY491/492 to stimulate the catalytic, proapoptotic, and antiadhesion/antimigration activities of DAPK. Conversely, Src phosphorylates DAPK at Y491/492, which induces DAPK intra-/intermolecular interaction and in... | SIGNOR-276074 |
P12882 | Q06413 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.383 | Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. We show that the upstream promoter region of the gene most abundantly expressed in mouse skeletal muscles, IIb MyHC, retains binding activity and transcriptional activation for three positive tra... | SIGNOR-238754 |
P24928 | Q14004 | 0 | phosphorylation | up-regulates activity | 0.541 | Together, these studies demonstrate the important, yet largely redundant, role for CDK12 and CDK13 for the regulation of POLII CTD phosphorylation at multiple residues, as well as the global role for both of these kinases in regulating POLII occupancy across the genome.|CDK12 and CDK13 are thus evolutionarily related a... | SIGNOR-273054 |
O00429 | P00519 | 0 | phosphorylation | up-regulates activity | 0.26 | In this study, we found that c-Abl phosphorylated Drp1 at tyrosine 266, 368 and 449 in vitro and in vivo, which augmented the GTPase activity of Drp1 and promoted Drp1-mediated mitochondrial fragmentation. | SIGNOR-277328 |
Q16539 | Q14934 | 1 | phosphorylation | down-regulates activity | 0.402 | P38 MAP kinase phosphorylates Ser168 and Ser170 of NFATc4. Mutational replacement of Ser168,170 with Ala promotes NFATc4 nuclear localization and increases NFATc4-mediated transcription activity. | SIGNOR-250107 |
P49841 | P03372 | 1 | phosphorylation | up-regulates | 0.34 | The gsk-3 inhibitor lithium chloride was used to determine the role of gsk-3 in phosphorylation of ser-102, -104, and -106 and ser-118 in vivo and to explore the role of these serines in the regulation of eralpha function. Treatment of cells with lithium chloride resulted in dephosphorylation of ser-104 and -106 and se... | SIGNOR-139316 |
Q92598 | P19784 | 0 | phosphorylation | down-regulates activity | 0.327 | Protein kinase CK2 phosphorylates Hsp105 alpha at Ser509 and modulates its function. | the phosphorylation of Hsp105 alpha at Ser(509) abolished the inhibitory activity of Hsp105 alpha in vitro. | SIGNOR-251008 |
Q15751 | P62195 | 1 | ubiquitination | down-regulates quantity | 0.2 | HERC1 interacts with and ubiquitinates nascent PSMC5.|PSMC5 produced in the absence of PAAF1 is presumably misfolded (consistent with its aggregation in the PURE system), triggering PSMC5 degradation by a HERC1-independent pathway. | SIGNOR-278812 |
Q00987 | Q06187 | 0 | phosphorylation | down-regulates activity | 0.278 | Phosphorylation of MDM2 by BTK suppresses its ubiquitination activity. | SIGNOR-278330 |
P43694 | Q9UI47 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.25 | GATA-4 and MEF2C are known to bind to the GATA box 2 in the major promoter of CTNNA3 and this element is essential in directly regulating expression of CTNNA3 in cardiac muscle cells. The co-transfection of GATA-4 with MEF2C leads to a synergistic activation of the CTNNA3 promoter | SIGNOR-265490 |
O15350 | P45983 | 0 | phosphorylation | up-regulates activity | 0.42 | Therefore, it is likely that p73 recruitment to the \u0394Np73 promoter is mediated by its JNK-1-dependent phosphorylation. | SIGNOR-279219 |
P49840 | P17612 | 0 | phosphorylation | down-regulates | 0.372 | Phosphorylation of ser21 and inactivation of glycogen synthase kinase 3 by protein kinase a. | SIGNOR-83221 |
O60260 | O00429 | 1 | ubiquitination | down-regulates quantity | 0.2 | Parkin interacts with and subsequently ubiquitinates Drp1, thus promoting its proteasome dependent degradation .|We have demonstrated that parkin promotes Drp1 degradation after OGDR insult. | SIGNOR-278589 |
O75154 | P06493 | 0 | phosphorylation | up-regulates quantity | 0.2 | FIP3 is phosphorylated on S102 in a cell cycle-dependent manner. We identify four sites of phosphorylation of FIP3 in vivo, S-102, S-280, S-347 and S-450 and identify S-102 as a target for Cdk1-cyclin B in vitro. Of these, we show that S-102 is phosphorylated in metaphase and is dephosphorylated as cells enter telophas... | SIGNOR-273588 |
P29474 | P00519 | 0 | phosphorylation | up-regulates activity | 0.2 | Two kinases, i.e. abelson-tyrosine protein kinase (ABL)1 and Src were identified as eNOS Tyr81 kinases as their inhibition and down-regulation significantly reduced the basal and Yoda1-induced tyrosine phosphorylation and activity of eNOS. | SIGNOR-277519 |
Q8TEW0 | Q7KZI7 | 0 | phosphorylation | up-regulates | 0.493 | Gab1 brings par1 and par3 into a transient complex, stimulating par3 phosphorylation by par1 | SIGNOR-198742 |
P08631 | Q92556 | 1 | phosphorylation | up-regulates | 0.606 | We previously showed that elmo1 binds directly to the hck sh3 domain and is phosphorylated by hck. In this study, we used mass spectrometry to identify the following sites of elmo1 phosphorylation: tyr 18, tyr 216, tyr 511, tyr 395, and tyr 720. Mutant forms of elmo1 lacking these sites were defective in their ability ... | SIGNOR-138154 |
P35548 | Q9Y458 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.309 | the main function of TBX22 as shown in misexpression experiments is to decrease proliferation. We subsequently uncovered three targets of TBX22, DLX5, MSX2, and TBX22 itself. All are downregulated in the presence of viral-derived hTBX22. | SIGNOR-265567 |
P07948 | P31995 | 1 | phosphorylation | up-regulates activity | 0.2 | Fyn and Blk definitely phosphorylate Y-282 in the ITAM of FcgRIIa/c, whereas the non-ITAM tyrosine residue (Y-275) becomes phosphorylated by Syk, as the phosphorylation of double point mutants shows. In addition to these tyrosine residues, Fyn, Blk, and Syk might phosphorylate the most C-terminal tyrosine residue (Y-29... | SIGNOR-262676 |
P17612 | P52888 | 1 | phosphorylation | up-regulates activity | 0.307 | PKA phosphorylation is suggested to play a regulatory role in EP24.15 enzyme activity. Mutation analysis of each putative PKA site, in vitro phosphorylation, and phosphopeptide mapping indicated serine 644 as the phosphorylation site. The most dramatic change upon PKA phosphorylation was a substrate-specific, 7-fold in... | SIGNOR-250060 |
P62805 | Q14493 | 0 | translation regulation | up-regulates quantity by expression | 0.2 | Synthesis of mature histone mRNA requires only a single processing reaction: an endonucleolytic cleavage between a conserved stem-loop and a purine-rich downstream element to form the 3' end. The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cy... | SIGNOR-265376 |
Q12913 | O43561 | 1 | dephosphorylation | down-regulates activity | 0.353 | Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation | SIGNOR-248696 |
Q07820 | P49841 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.5 | MCL-1 was phosphorylated by GSK-3 at a conserved GSK-3 phosphorylation site (S159). S159 phosphorylation of MCL-1 was induced by IL-3 withdrawal or PI3K inhibition and prevented by AKT or inhibition of GSK-3, and it led to increased ubiquitinylation and degradation of MCL-1. | SIGNOR-251242 |
P48729 | P30304 | 1 | phosphorylation | down-regulates | 0.333 | Here, we report that casein kinase 1 alpha (ck1alpha) phosphorylates cdc25a on both s79 and s82 in a hierarchical manner requiring prior phosphorylation of s76 by chk1 or gsk-3beta. This facilitates beta-trcp binding and ubiquitin-mediated proteolysis of cdc25a | SIGNOR-164734 |
P12931 | O14874 | 1 | phosphorylation | up-regulates activity | 0.2 | Src phosphorylated BCKDK at the tyrosine 246 (Y246) site in vitro and ex vivo. Knockdown and knockout of Src downregulated the phosphorylation of BCKDK. Importantly, phosphorylation of BCKDK by Src enhanced the activity and stability of BCKDK, thereby promoting the migration, invasion, and EMT of CRC cells. | SIGNOR-275583 |
Q8N3U4 | P53350 | 0 | dephosphorylation | down-regulates activity | 0.737 | Two phosphorylation sites in Scc1 (Thr144 and Thr312) match the consensus proposed by Nakajima et al. [24]. These two sites, in addition to one in Scc1 (Ser454) and three in SA2 (Thr1109, Ser1137, and Ser1224) conform with the consensus proposed by Barr et al. [25]. These findings are consistent with the possibility th... | SIGNOR-275534 |
Q9H0M0 | Q4VCS5 | 1 | ubiquitination | up-regulates quantity by stabilization | 0.275 | Here low serum and high LATS1 activity are found to enhance the levels of the 130-kDa isoform of angiomotin (Amot130) through phosphorylation by LATS1/2 at serine 175, which then forms a binding site for 14-3-3. Such phosphorylation, in turn, enables the ubiquitin ligase atrophin-1 interacting protein (AIP)4 to bind, u... | SIGNOR-275847 |
O15194 | Q15797 | 1 | dephosphorylation | down-regulates activity | 0.498 | Smad proteins transduce bone morphogenetic protein (BMP) and transforming growth factor-beta (TGFbeta) signals upon phosphorylation of their C-terminal SXS motif by receptor kinases.|Phosphatases that dephosphorylate the linker region are therefore likely to play an integral part in the regulation of Smad activity. We ... | SIGNOR-248314 |
P49841 | Q99684 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.2 | GSK3β-mediated GFI1 S94/S98 phosphorylation triggered its interaction with FBXW7, resulting in SCFFBXW7-mediated ubiquitination and degradation. | SIGNOR-277465 |
P53779 | O14733 | 0 | phosphorylation | up-regulates | 0.582 | Two mapkks, sek1 and mkk7, synergistically activate jnk. Sek1 prefers the tyr-185 residue, and mkk7 prefers the thr-183 residue (17, 19). | SIGNOR-137609 |
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