IdA string | IdB string | labels int64 | mechanism string | effect string | score float64 | sentence string | signor_id string |
|---|---|---|---|---|---|---|---|
Q09472 | Q9HCU9 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.363 | BRMS1 suppresses lung cancer metastases through an E3 ligase function on histone acetyltransferase p300. BRMS1 induces polyubiquitination of p300, resulting in its proteasome-mediated degradation. | SIGNOR-266408 |
O14654 | P78368 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.2 | IRS4 was phosphorylated at Ser859 by CK1γ2 in vitro and in vivo, which promoted the polyubiquitination and degradation of IRS4 through the ubiquitin/lysosome pathway by the carboxyl terminus of Hsc70-interacting protein(CHIP). | SIGNOR-277615 |
P28482 | Q8WZ42 | 1 | phosphorylation | up-regulates quantity | 0.387 | ERK2 phosphorylates three serines in titin\u2019s N2B-Us: S3918, S3960, and S4010 (the latter of which is well conserved) (). | SIGNOR-279636 |
Q05513 | Q9Y243 | 1 | phosphorylation | up-regulates activity | 0.546 | Full activation of the PKB enzyme requires phosphorylation of a threonine in the activation | SIGNOR-249153 |
P35226 | P68400 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.269 | Here we report that CK2α, a nuclear serine threonine kinase, phosphorylates BMI1 at Serine 110 as determined by in-vitro/ex-vivo kinase assay and mass spectrometry. e-expression of the phosphorylatable but not non-phosphorylatable BMI1 rescued clonal growth in endogenous BMI1 silenced cancer cells leading us to specula... | SIGNOR-277345 |
P00519 | P40692 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.344 | We also observed phosphorylation of MLH1 by ABL1 in an in vitro kinase assay with purified recombinant ABL1 and MLH1, confirming there is a direct phosphorylation between ABL1 and the MLH1 component of the MLH1-PMS2 heterodimer.|we propose that ABL1 prevents MLH1 from being targeted for degradation by the chaperone Hsp... | SIGNOR-279581 |
P12814 | Q9BYB0 | 0 | relocalization | up-regulates activity | 0.2 | SHANK proteins are ‘master’ scaffolding proteins that tether and organize intermediate scaffolding proteins. They are located at excitatory synapses, where they are crucial for proper synaptic development and function. SAPAP proteins subsequently bind to the PDZ domain of members of the SHANK protein family. SHANK prot... | SIGNOR-264585 |
Q9H6T0 | Q6ZNA4 | 0 | ubiquitination | up-regulates activity | 0.388 | These findings suggest that Arkadia ubiquitinates ESRP2 and potentiates the splicing function of ESRP2 ( ). | SIGNOR-278613 |
P25116 | P08311 | 0 | cleavage | down-regulates activity | 0.583 | PAR1E and PAR2E (10 microM) were incubated in the presence of the different proteases | The enzymes were used at the following concentrations: 0.5 unit/mL thrombin, 2.5 nM trypsin, 20 nM plasmin, 20 nM cathepsin G, 20 nM elastase, 20 nM proteinase 3, and 2 units/mL calpain I and II|Protease-activated receptors (PARs) m... | SIGNOR-263564 |
Q96GF1 | Q12981 | 1 | polyubiquitination | up-regulates activity | 0.533 | RNF185 functions as a ubiquitin E3 ligase, enabling BNIP1-p62 interaction. Here we show that human RNF185 is a mitochondrial ubiquitin E3 ligase that regulates selective mitochondrial autophagy in cultured cells. Human BNIP1 colocalizes with RNF185 at mitochondria and is polyubiquitinated by RNF185 through K63-based u... | SIGNOR-271931 |
P60484 | O15327 | 0 | dephosphorylation | down-regulates activity | 0.632 | In support, the increase in PTEN caused by INPP4B knockdown was associated with increased phosphorylation of the Ser380, Thr382, Thr383 and Ser385 cluster of the protein (XREF_FIG), which is known to increase PTEN half-life, in colon cancer cells.|Exogenous INPP4B could pull down and dephosphorylate endogenous PTEN, su... | SIGNOR-277018 |
P36873 | P04637 | 1 | dephosphorylation | down-regulates activity | 0.318 | Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities|In addition, our results reveal that one of the molecular mechanisms by which PP-1 promotes cell survival is to dephosphorylate p53, and thus negatively regulate p53-dependent death ... | SIGNOR-248499 |
Q13976 | P19429 | 1 | phosphorylation | up-regulates activity | 0.357 | Phosphorylation at ser 23/24 (e.g., by pka or pkg) results in reduction in myofilament ca2+ sensitivity and an increase in crossbridge cycling rate, leading to acceleration of relaxation and an increase in power output but a reduced economy of contraction. Conversely, phosphorylation at ser 43/45 (by pkc) is associated... | SIGNOR-134644 |
Q8N2Q7 | P78352 | 1 | relocalization | up-regulates activity | 0.776 | Like NRXNs, NLGNs bind to intracellular PDZ-domain proteins, but in contrast to NRXNs, NLGNs bind to class I PDZ domains such as those contained in PSD95, a postsynaptic MAGUK protein65. PSD95 and its homologues are centrally involved in recruiting glutamate receptors at postsynaptic sites66. Similarly to CASK, PSD95 b... | SIGNOR-264191 |
Q4VCS5 | Q9H0M0 | 0 | ubiquitination | up-regulates quantity by stabilization | 0.275 | Here low serum and high LATS1 activity are found to enhance the levels of the 130-kDa isoform of angiomotin (Amot130) through phosphorylation by LATS1/2 at serine 175, which then forms a binding site for 14-3-3. Such phosphorylation, in turn, enables the ubiquitin ligase atrophin-1 interacting protein (AIP)4 to bind, u... | SIGNOR-275847 |
Q9BSJ6 | Q8TAS1 | 0 | phosphorylation | up-regulates | 0.2 | Cats is a substrate of kis and mapped the phosphorylation site to cats serine 131 (s131). Kis enhances the transcriptional repressor activity of cats | SIGNOR-192702 |
Q16539 | Q9H1K0 | 1 | phosphorylation | up-regulates | 0.2 | We found that p38alpha can phosphorylate the rab5 effectors eea1 and rabenosyn-5 on thr-1392 and ser-215, respectively, and these phosphorylation events regulate the recruitment of eea1 and rabenosyn-5 to membranes | SIGNOR-140143 |
Q13188 | P31749 | 0 | phosphorylation | down-regulates | 0.356 | We determined that mst2 phosphorylation by akt limits mst2 activity in two ways: first, by blocking its binding to rassf1a and by promoting its association into the raf-1 inhibitory complex, and second, by preventing homodimerization of mst2, which is needed for its activation. we identified t117 and t384 as akt phosp... | SIGNOR-163533 |
O96017 | P78527 | 0 | phosphorylation | up-regulates | 0.59 | We have found that dna-pk is the major constituent of an activity present in extracts of mammalian cells that phosphorylates chk2. Our results suggest that hypophosphorylated chk2 can be phosphorylated at thr68 by dna-pk in vitro. | SIGNOR-133384 |
Q76NI1 | P11137 | 1 | phosphorylation | up-regulates activity | 0.369 | V-KIND enhances Thr phosphorylation of MAP2. | SIGNOR-278950 |
P17252 | O75385 | 1 | phosphorylation | down-regulates activity | 0.2 | ULK1 is phosphorylated by PKCalpha at S423 in vivo and in vitro.|PKC\u03b1 phosphorylation of ULK1 does not change its kinase activity | SIGNOR-279558 |
Q12774 | P61586 | 1 | guanine nucleotide exchange factor | up-regulates activity | 0.617 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260533 |
Q12972 | P17612 | 0 | phosphorylation | down-regulates activity | 0.484 | NIPP-1 is the RNA-binding subunit of a major species of protein phosphatase-1 in the nucleus. The purified recombinant protein was a potent (Ki = 9.9 +/- 0.3 pM) and specific inhibitor of protein phosphatase-1 and was stoichiometrically phosphorylated by protein kinases A and CK2. At physiological ionic strength, phosp... | SIGNOR-250033 |
P18206 | P23470 | 0 | dephosphorylation | down-regulates activity | 0.2 | PTPRG activation by the P1-WD peptide affected the tyrosine phosphorylation of several signaling molecules. Data analysis identified 31 molecules whose phosphorylation was modified in a statistically significant manner (Table I). inhibition of ABL1, BMX, BTK, DAB1, ITGB1, JAK2, KDR, KIT, LIMK1, MET, PDGFRB, SHC1, and V... | SIGNOR-254731 |
P42224 | P07949 | 0 | phosphorylation | up-regulates activity | 0.275 | In detail, RET and PTC3 induced STAT1 overexpression and phosphorylation at Ser 727 and Tyr 701. | SIGNOR-279276 |
P06493 | P39748 | 1 | phosphorylation | down-regulates activity | 0.446 | Phosphorylation of human fen1 by cyclin-dependent kinase modulates its role in replication fork regulation.As a functional consequence of phosphorylation by cdk1-cyclin a in vitro, endo- and exonuclease activities of fen1 are reduced whereas its dna binding is not affected. | SIGNOR-103535 |
Q2MKA7 | Q9ULT6 | 1 | relocalization | down-regulates quantity | 0.803 | Mechanistically, R-spondin interacts with the extracellular domain of ZNRF3 and induces the association between ZNRF3 and LGR4, which results in membrane clearance of ZNRF3. These data suggest that R-spondin enhances Wnt signalling by inhibiting ZNRF3. | SIGNOR-260113 |
P08134 | Q9NQU5 | 0 | phosphorylation | down-regulates activity | 0.2 | It is possible that Pak6 may directly phosphorylate RhoC to regulate its activity.|Nevertheless, our results clearly show that the kinase activity of Pak6 is required to inhibit RhoC induced cell contraction. | SIGNOR-280059 |
Q05655 | Q01543 | 1 | phosphorylation | down-regulates | 0.346 | We have previously demonstrated that in response to transforming growth factor _ (tgf_), fli-1 activity is repressed through a series of sequential posttranslational modifications, consisting of protein kinase c_ (pkc_)-induced thr312 phosphorylation, acetylation by p300/creb binding protein-associated factor, and deta... | SIGNOR-172113 |
P01106 | P30279 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.45 | C-myc directly activates transcription of cyclin d1, cyclin d2 and cdk4, and leads to cdk 4/6 activation. | SIGNOR-27446 |
P04629 | P12931 | 0 | phosphorylation | up-regulates activity | 0.292 | Direct phosphorylation of TrkA by Src family kinases has been demonstrated in vitro, and our studies suggest that Src may lead to selective activation of TrkA. | SIGNOR-279291 |
O43623 | Q9ULU4 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.2 | Our quantitative ChIP experiments confirmed that ZMYND8 and JARID1D were co-localized at Slug, CD44, VEGFA, and EGFR genes (Figures 4F–4I). Our ChIP results also showed that ZMYND8 repressed and occupied other JARID1D target genes, such as the matrix metalloproteinase 1 (MMP1) and MMP3, that we previously reported | SIGNOR-262038 |
Q9BYG3 | P49841 | 0 | phosphorylation | up-regulates activity | 0.2 | The forkhead-associated (FHA) domain of human Ki67 interacts with the human nucleolar protein hNIFK, recognizing a 44-residue fragment, hNIFK226-269, phosphorylated at Thr234. Here we show that high-affinity binding requires sequential phosphorylation by two kinases, CDK1 and GSK3, yielding pThr238, pThr234 and pSer23... | SIGNOR-262698 |
P50613 | P04637 | 1 | phosphorylation | up-regulates | 0.458 | The cdk7-cych-p36 complex of transcription factor iih phosphorylates p53, enhancing its sequence-specific dna binding activity in vitro. serines 371, 376, 378, and 392 may be the potential sites for this kinase. | SIGNOR-51292 |
P11274 | P37231 | 1 | phosphorylation | down-regulates activity | 0.2 | Overexpression of Bcr WT inhibited PPARgamma transcriptional activity (XREF_FIG).|Point-mutation and in vitro kinase analysis showed that PPAR\u03b3 was phosphorylated by Bcr at serine 82. | SIGNOR-279441 |
O15143 | O14965 | 0 | phosphorylation | up-regulates activity | 0.46 | Aurora A phosphorylates Arpc1b on threonine 21, and expression of Arpc1b but not a nonphosphorylatable Arpc1b mutant in mammalian cells leads to Aurora A kinase activation and abnormal centrosome amplification in a Pak1-independent manner. | SIGNOR-279438 |
P35568 | Q13627 | 0 | phosphorylation | up-regulates quantity | 0.2 | DYRK1A interacts with IRS-1 and phosphorylates IRS-1 at Ser-312 and Ser-616.|We found that DYRK1A overexpression up-regulated IRS-1 expression by slowing the turnover of IRS-1 protein. | SIGNOR-279521 |
P49137 | Q07352 | 1 | phosphorylation | down-regulates | 0.62 | Mk2-mediated inhibition of brf1 requires phosphorylation at s54, s92, and s203. Phosphorylation of brf1 by mk2 does not appear to alter its ability to interact with ares or to associate with mrna decay enzymes. Thus, mk2 inhibits brf1-dependent amd through direct phosphorylation. | SIGNOR-161274 |
P05114 | P17252 | 0 | phosphorylation | down-regulates | 0.307 | Protein kinases that phosphorylate hmg-14 17 at the major sites have been implicated from previous in vitro studies. Protein kinase c and a similar calcium phospholipid-dependent kinase have been reported to phosphorylate both proteins in vitro, where the phosphorylation of hmg-17 occurs predominantly at ser24 and to a... | SIGNOR-76286 |
P68400 | P18146 | 1 | phosphorylation | down-regulates activity | 0.464 | Casein kinase II associates with Egr-1 and acts as a negative modulator of its DNA binding and transcription activities in NIH 3T3 cells. | There are three CKII recognition sites (S376XXD, T389XE, and T516XXXD) in fragment 10. | SIGNOR-250858 |
Q12778 | P48729 | 0 | phosphorylation | down-regulates | 0.418 | Additionally, ck1, dyrk1a, and cdk2 also phosphorylate foxos at various sites to inhibit foxos activity | SIGNOR-183658 |
Q9NTX7 | O15234 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.262 | Here, we identify RNF146, a RING-domain E3 ubiquitin ligase, as a positive regulator of Wnt signalling. RNF146 promotes Wnt signalling by mediating tankyrase-dependent degradation of axin. Mechanistically, RNF146 directly interacts with poly(ADP-ribose) through its WWE domain, and promotes degradation of PARsylated pro... | SIGNOR-263339 |
O75582 | P16220 | 1 | phosphorylation | up-regulates | 0.731 | Msk1 is localized in the nucleus of unstimulated or stimulated cells, and phosphorylates creb at ser133_ .MSK1 Is activated in vitro by mapk2/erk2 or sapk2/p38. Endogenous msk1 is activated in 293 cells by either growth factor/phorbol ester stimulation, or by exposure to uv radiation, and oxidative and chemical stres m... | SIGNOR-59458 |
P30411 | Q05655 | 0 | phosphorylation | down-regulates activity | 0.301 | In addition, we found a protein kinase C-dependent phosphorylation of Ser(346) that was mutually exclusive with the basal phosphorylation at Ser(348) and therefore may be implicated in differential regulation of B2 receptor activation. Functional analysis of receptor mutants revealed that a low phosphorylation stoichio... | SIGNOR-249108 |
O14939 | P17252 | 0 | phosphorylation | up-regulates | 0.692 | The phosphorylation sites in phospholipase d2 (pld2) induced by activation of protein kinase calpha (pkcalpha) in cos 7 cells were analyzed by mass spectrometry. Ser134, 146, and 243, and thr72, 99/100, and 252 were identified. These sites were mutated to ala and the double mutation of ser243 and thr252 eliminated the ... | SIGNOR-138355 |
P46734 | Q9Y463 | 1 | phosphorylation | up-regulates | 0.348 | Mkk3 enhanced mirk kinase activity. Mkk3 possibly activates mirk by phosphorylating it. | SIGNOR-86731 |
P29353 | Q05655 | 0 | phosphorylation | up-regulates | 0.569 | Pkc delta phosphorylates p52shca at ser29 to regulate erk activation in response to h2o2. | SIGNOR-149398 |
P35222 | Q8N752 | 0 | phosphorylation | down-regulates | 0.508 | We show that a complex of axin and casein kinase i (cki) induces beta-catenin phosphorylation at a single site: serine 45 (s45). | SIGNOR-87430 |
P25490 | Q92769 | 0 | deacetylation | down-regulates activity | 0.769 | Previous studies have established that YY1 interacts with histone acetyltransferases p300 and CREB-binding protein (CBP) and histone deacetylase 1 (HDAC1), HDAC2, and HDAC3. Here, we present evidence that the activity of YY1 is regulated through acetylation by p300 and PCAF and through deacetylation by HDACs. YY1 was a... | SIGNOR-268836 |
P46940 | Q02156 | 0 | phosphorylation | up-regulates | 0.2 | Using a mass spectrometry-based assay, we show that egf induces phosphorylation of iqgap1 ser(1443), a residue known to be phosphorylated by pkcthe nonphosphorylatable iqgap1 s1441a/s1443a had no effect. In contrast, the s1441e/s1443d mutation markedly enhanced the ability of iqgap1 to induce neurite outgrowth. | SIGNOR-128718 |
P02749 | P00747 | 0 | cleavage | down-regulates activity | 0.458 | Plasmin can reduce the function of human beta2 glycoprotein I by cleaving domain V into a nicked form| The cleavage site of r-Domain V and beta2GPI by plasmin was proved to be Lys 317-Thr 318 by amino acid sequence analysis of the digest and of the C-terminal peptide isolated by high-performance liquid chromatography. ... | SIGNOR-266996 |
Q8TDX7 | Q8TD19 | 0 | phosphorylation | up-regulates activity | 0.715 | Nercc1 catalyzes the phosphorylation of nek6 (ser206) and the equivalent site on nek7 (ser195), resulting in a 20-25-fold activation of nek6/7 kinase activity | SIGNOR-103030 |
P53350 | P25490 | 1 | phosphorylation | up-regulates | 0.392 | More recently, we identified and mapped multiple phosphorylation sites in yy1, including, threonine 39, serine 118, serine 247, threonine 348 and threonine 378. The first kinase proven to phosphorylate yy1 in vivo was plk1, which phosphorylates threonine 39 during g2/m stage of the cell cycle [25]. Ck2_ is another kina... | SIGNOR-200087 |
P01112 | Q7Z5G4 | 0 | palmitoylation | up-regulates activity | 0.349 | Covalent lipid modifications mediate the membrane attachment and biological activity of Ras proteins. All Ras isoforms are farnesylated and carboxyl-methylated at the terminal cysteine; H-Ras and N-Ras are further modified by palmitoylation. Here we report that H- and N-Ras are palmitoylated by a human protein palmito... | SIGNOR-261351 |
O60260 | P55036 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.2 | S5a/Rpn10 is a ubiquitin (Ub)-binding protein that is a subunit of the 26S proteasome but also exists free in the cytosol. It binds poly-Ub chains through its two Ub-interacting motifs (UIMs). We discovered that, unlike typical substrates of Ub ligases (E3s), S5a can be ubiquitinated by all E3s tested including multime... | SIGNOR-272749 |
Q13557 | P51787 | 1 | phosphorylation | down-regulates activity | 0.2 | CaMKII regulates KCNQ1 at S484 during sustained β-AR stimulation to inhibit IKs. The ability of CaMKII to inhibit IKs may contribute to arrhythmogenicity during HF. | SIGNOR-275479 |
Q9Y243 | O15119 | 1 | phosphorylation | up-regulates activity | 0.354 | We have identified TBX3 as a key substrate of AKT3 in melanomagenesis. we have identified the AKT3 target site at serine residue 720 in the TBX3 protein and show that this site is phosphorylated in vivo. the phosphorylation at S720 promotes TBX3 protein stability, nuclear localization, transcriptional repression of E-c... | SIGNOR-223534 |
Q92886 | Q9HCK8 | 0 | transcriptional regulation | down-regulates quantity | 0.2 | Many of the most significantly up-regulated genes in Chd8+/− and Chd8−/− NPCs are involved in later stages of neuronal development, including Ascl1 [a central driver of neural reprogramming (29)], Dcx, Map2, Nefm, Neurod4, and Neurog1 (Fig. 2 E and F). Additionally, we found that Sox3 is derepressed in both Chd8+/− and... | SIGNOR-268919 |
Q8IWV1 | P06239 | 0 | phosphorylation | up-regulates activity | 0.399 | Upon stimulation via the B or T cell receptors, LAX is rapidly phosphorylated by Src and Syk family tyrosine kinases and interacts with Grb2, Gads, and p85. | SIGNOR-273528 |
Q9Y4K3 | P0C6X7-PRO_0000037311 | 0 | deubiquitination | down-regulates activity | 0.2 | Also, SARS-CoVPLPro catalyzed deubiquitination ofTNF-receptor-associatedfactor3(TRAF3)and TRAF6, thereby suppressing IFN-I and proinflammatory cytokines induced by TLR7 agonist | SIGNOR-260248 |
Q13464 | P26038 | 1 | phosphorylation | up-regulates activity | 0.688 | Rho-associated kinase (Rho-kinase), which is activated by the small GTPase Rho, phosphorylates moesin at Thr558 in vitro. Here, using a site- and phosphorylation state-specific antibody, we found that the expression of dominant active RhoA in COS7 cells induced moesin phosphorylation and the formation of microvilli-lik... | SIGNOR-249014 |
Q02750 | P35568 | 1 | phosphorylation | down-regulates | 0.352 | Thus, at least three kinases mediate phosphorylation of ser307, including jnk, serine kinases in the pi 3-kinase cascade that are activated byinsulinor igf-1, and mek1-sensitive kinase cascades during tnf-alfa stimulation. | SIGNOR-236611 |
P20719 | O15550 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.27 | Evidence for direct involvement of UTX in regulation of HOX gene activity was demonstrated through UTX knockdown experiments in HEK293T cells in which loss of UTX induced transcriptional repression of HOXA and HOXC clusters. | SIGNOR-260023 |
P61586 | Q9UKW4 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.711 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260584 |
Q13976 | O96001 | 1 | phosphorylation | up-regulates | 0.656 | Recombinant human G-substrate was phosphorylated efficiently by cGMP-dependent protein kinase exclusively at Thr residues, and it was recognized by antibodies specific for rabbit phospho-G-substrate. The amino acid sequences surrounding the sites of phosphorylation in G-substrate are related to those around Thr-34 and ... | SIGNOR-263148 |
P42224 | P17706 | 0 | dephosphorylation | down-regulates activity | 0.734 | Upon ligand binding, IL-2R , IL-6R or LeptinR , IFN-_R , IFN-_R and PRLR or growth hormone (GH) receptor associated JAKs become activated. These JAKs mediate phosphorylation of specific tyrosine residues and recruit STATs. Activated STATs are released from the receptor and translocate to the nucleus. PTP1B dephosphory... | SIGNOR-133279 |
O15379 | Q8NHE4 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.2 | Consistent with previous data, HDAC3 only bound to the ATP6V0E2 promoter in the presence of ALDH2.|Taken together, our data demonstrate that in the macrophages of LDLR-KO or ALDH2 rs671 mutant, AMPK phosphorylates ALDH2 at T356, which enables its nuclear translocation. Once in the nucleus, ALDH2 binds to HDAC3 and supp... | SIGNOR-271868 |
Q96J02 | O95999 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.276 | The HECT domain ubiquitin ligases NEDD4 and Itch promote ubiquitination and degradation of Bcl10, thus downmodulating NF-kappa B activation. | SIGNOR-271414 |
Q96PD2 | P06241 | 0 | phosphorylation | up-regulates activity | 0.35 | Mutagenesis analysis of ESDN's seven intracellular tyrosines in YxxP motifs found several contribute to the binding of ESDN to the SH2 domains of both CrkCT10 regulator of kinase Crk-Like (CrkL) and a representative SFK Fyn. Quantitative mass spectrometry showed that at least three of these (Y565, Y621 and Y750), as we... | SIGNOR-273946 |
O00141 | P15056 | 1 | phosphorylation | down-regulates activity | 0.344 | Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf.|We observed that SGK inhibits B-Raf activity. | SIGNOR-279110 |
P68400 | O75822 | 1 | phosphorylation | up-regulates activity | 0.326 | CK2 phosphorylates the eIF3j subunit at Ser127. CK2-phosphorylation of eIF3j triggers its association with the eIF3 complex. | SIGNOR-266402 |
P19174 | P38936 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.262 | Phosphorylation at Ser-146 by PKCδ increases p21 stability | SIGNOR-262962 |
Q13490 | P57078 | 1 | polyubiquitination | up-regulates activity | 0.355 | CIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).Together, our results demonstrate that depleting cIAP1/2 inhibits RIP1-4 mediated NF-kB activation without affecting RIP auto-phosphorylation.Lysine residues K51 and K145 of RIP4 are crit... | SIGNOR-272708 |
P06241 | Q9HBA0 | 1 | phosphorylation | up-regulates activity | 0.35 | ROS could be detected by Fyn, which is required to activate TRPV4 in a redox-sensitive manner.|The Ca 2+ response to H 2 O 2 required the basal phosphorylation of TRPV4 by the Src kinase Fyn, which may serve as the redox sensor responsible for TRPV4 activation (Figure 2 ) [220] , and was able to increase barrier permea... | SIGNOR-279991 |
P16949 | Q00535 | 0 | phosphorylation | down-regulates | 0.376 | Involved in the regulation of the microtubule (mt) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. The kinases involved in phosphorylating stmn ser-16 and ser-63 include camp-dependent protein kinase (pka) and pak1, whereas stmn ser-25 and ser-38 have been show... | SIGNOR-166682 |
Q9Y4K3 | P49768 | 1 | ubiquitination | up-regulates quantity by stabilization | 0.559 | We have also observed that ubiquitination of PS1 by TRAF6 increases the stability of PS1 holoprotein, and TRAF6-deficiency coincides with reduced endogenous PS1 and PS2 levels. | SIGNOR-278601 |
P07947 | O15524 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.2 | Samples from human lymphomas that often overexpress SOCS1 also displayed SRC family kinase activation, constitutive phosphorylation of SOCS1 on Y80, and SOCS1 cytoplasmic localization. | SIGNOR-277453 |
P62136 | P27361 | 1 | dephosphorylation | down-regulates | 0.444 | P-erk1/2 proteins were efficiently dephosphorylated in vitro by protein phosphatases 1 and 2a (pp1/2a) and mapk phosphatase 3 (mkp3). the dual specificity phosphatases that specifically dephosphorylate and inactivate the p-erk1/2 are called mapk phosphatases | SIGNOR-103155 |
Q00613 | Q9H422 | 0 | phosphorylation | up-regulates activity | 0.335 | We show that Yak1 directly phosphorylates Hsf1 in vitro, leading to the increase in DNA binding activity of Hsf1. | SIGNOR-279054 |
Q9UHW9 | Q9BYP7 | 0 | phosphorylation | down-regulates activity | 0.444 | WNK3, which inhibits the activity of KCC3, promoted phosphorylation of Ser-96 as well as Thr-991 and Thr-1048. | SIGNOR-260912 |
Q9BXM7 | O15379 | 1 | phosphorylation | up-regulates activity | 0.2 | PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death.|PINK1 prevents H2O2-induced C-terminal cleavage of HDAC3 via phosphorylation of HDAC3 at Ser-424, which is reversed by protein phosphatase 4c. | SIGNOR-279093 |
Q6PIY7 | P17612 | 0 | phosphorylation | down-regulates activity | 0.2 | We found that Gld2 activity is regulated by site-specific phosphorylation in its disordered N-terminal domain. We identified two phosphorylation sites (S62, S110) where phosphomimetic substitutions increased Gld2 activity and one site (S116) that markedly reduced activity. Using mass spectrometry, we confirmed that HEK... | SIGNOR-259402 |
P06737 | O15294 | 0 | glycosylation | up-regulates activity | 0.2 | O-GlcNAcylation at Ser-430 promotes PYGL activity | SIGNOR-267988 |
P07948 | P43405 | 1 | phosphorylation | up-regulates activity | 0.61 | Lyn phosphorylates and activates Syk and LAT. | SIGNOR-279415 |
Q9NS91 | Q12888 | 1 | ubiquitination | up-regulates activity | 0.611 | RAD18 associates with 53BP1 and is recruited to DSB sites in a 53BP1 dependent manner specifically during G1-phase, RAD18 monoubiquitinates KBD domain of 53BP1 at lysine 1268 in vitro.|These results suggest that RAD18 directed modification at Lysine 1268 of 53BP1 promotes the retention of 53BP1 at DSBs. | SIGNOR-278593 |
P07197 | Q9HCK8 | 0 | transcriptional regulation | down-regulates quantity | 0.2 | Many of the most significantly up-regulated genes in Chd8+/− and Chd8−/− NPCs are involved in later stages of neuronal development, including Ascl1 [a central driver of neural reprogramming (29)], Dcx, Map2, Nefm, Neurod4, and Neurog1 (Fig. 2 E and F). Additionally, we found that Sox3 is derepressed in both Chd8+/− and... | SIGNOR-268917 |
Q06413 | Q9UI47 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.241 | GATA-4 and MEF2C are known to bind to the GATA box 2 in the major promoter of CTNNA3 and this element is essential in directly regulating expression of CTNNA3 in cardiac muscle cells. The co-transfection of GATA-4 with MEF2C leads to a synergistic activation of the CTNNA3 promoter | SIGNOR-265491 |
P49674 | Q01974 | 1 | phosphorylation | up-regulates | 0.268 | We also show that ror2 is phosphorylated by ckiepsilon on serine/threonine residues. | SIGNOR-129117 |
O15111 | P42224 | 1 | phosphorylation | up-regulates activity | 0.331 | In addition, IKK\u03b1 also phosphorylated STAT1 in a type I IFN-independent manner [Fig 8, a dashed line (B)]. | SIGNOR-279732 |
P06493 | Q9UJX2 | 1 | phosphorylation | up-regulates | 0.636 | Apc activation is thought to depend on apc phosphorylation and cdc20 binding. We have identified 43 phospho_sites on apc of which at least 34 are mitosis specific. Of these, 32 sites are clustered in parts of apc1 and the tetratricopeptide repeat (tpr) subunits cdc27, cdc16, cdc23 and apc7. In vitro, at least 15 of the... | SIGNOR-119821 |
Q6P2H3 | P53350 | 0 | phosphorylation | up-regulates activity | 0.248 | In summary, our results identify Cep85 as a platform to directly relay the activities of Plk1 and Mst2 to Nek2A activation at centrosomes through phospho-Nek2A-assistant Cep85 phosphorylation by Plk1 at the onset of mitosis.|Plk1 Heavily Phosphorylates the Nek2A-Binding Domain in Cep85 at Centrosomes in Late G2. | SIGNOR-278367 |
P17612 | Q9P0L9 | 1 | phosphorylation | up-regulates activity | 0.2 | PKD2L1 channel activation by PKA phosphorylation. In this study, we observed the activity of PKD2L1 channel increased by the downstream cascades of β2AR and found the clustered phosphorylation sites, Ser-682, Ser-685, and Ser-686 that are significant in the channel regulation by phosphorylation. | SIGNOR-273562 |
Q02750 | Q01538 | 1 | phosphorylation | down-regulates activity | 0.261 | Altogether our findings reveal that Myt1 is inactivated by MEK1 mediated phosphorylation to fragment the Golgi complex in G2 and for the entry of cells into mitosis.|MEK1 inactivates Myt1 to regulate Golgi membrane fragmentation and mitotic entry in mammalian cells. | SIGNOR-279052 |
P20138 | P06239 | 0 | phosphorylation | up-regulates | 0.271 | Human cd33 has two tyrosine residues in its cytoplasmic domain (y340 and y358). When phosphorylated, these tyrosines could function as docking sites for the phosphatases, shp-1 and/or shp-2, enabling cd33 to function as an inhibitory receptor. Lck is effective at phosphorylating y340 | SIGNOR-78960 |
P13807 | Q16821 | 0 | dephosphorylation | up-regulates | 0.502 | In skeletal muscle, the activation of glycogen synthase by insulin involves the dephosphorylation of serine residues that are phosphorylated by gsk3 and dephosphorylated by the glycogen-associated form of protein phosphatase-l (pp1g). | SIGNOR-37301 |
P00519 | Q06187 | 1 | phosphorylation | down-regulates activity | 0.336 | In this report we describe for the first time that ABL1 and Btk physically interact and that ABL1 can phosphorylate tyrosine 223 in the SH3 domain of Btk. | This is presumably due to the negative regulatory effectof Btk SH3 domain phosphorylation caused by ABL1,which would result in a decreased catalytic activity ofBtk... | SIGNOR-260801 |
Q04206 | Q9Y618 | 1 | relocalization | down-regulates activity | 0.404 | Furthermore, overexpression of Flt3-ITD led to a partial relocalization of SMRT protein from the nucleus to the cytoplasm. This indicates that shuttling of p65 was necessary for Flt3-ITD-mediated SMRT nuclear export. | SIGNOR-261539 |
Q969H0 | Q71F56 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.359 | The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator. We show that Fbw7, a tumor suppressor and ubiquitin ligase, binds to CDK8-Mediator and targets MED13/13L for degradation. MED13/13L physically link the CDK8 module to Mediator, and Fbw7 loss increases CDK8 modul... | SIGNOR-266688 |
Q9BXM7 | Q12931 | 1 | phosphorylation | up-regulates activity | 0.612 | This would mean that PINK1 knockdown should reduce TRAP1 activity, thereby potentiating BAY induced cell death.|PINK1 can phosphorylate TRAP1 to prevent apoptosis induced by oxidative stress. | SIGNOR-278186 |
Q99728 | P03372 | 1 | ubiquitination | down-regulates quantity | 0.427 | As shown in xref , both FOXK2 and BARD1 enhanced the ubiquitination of ER\u03b1, with the extent of ubiquitination being enhanced when both FOXK2 and BARD1 were overexpressed.|These findings suggested that FOXK2 might act as a negative regulator of Estrogen receptor\u03b1, and its association with both Estrogen recepto... | SIGNOR-278803 |
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