IdA string | IdB string | labels int64 | mechanism string | effect string | score float64 | sentence string | signor_id string |
|---|---|---|---|---|---|---|---|
A2RUS2 | O75385 | 0 | phosphorylation | up-regulates activity | 0.435 | ULK-mediated phosphorylation of the guanine nucleotide exchange factor DENND3 at serines 554 and 572 upregulates its GEF activity toward the small GTPase Rab12. | SIGNOR-264731 |
P27361 | Q05682 | 1 | phosphorylation | down-regulates | 0.478 | The actin binding properties of the minimal inhibitory region of caldesmon, residues 750-779, alter upon map kinase phosphorylation of ser-759. This phosphorylation leads to markedly diminished actin affinity. | SIGNOR-86741 |
Q03112 | P62136 | 0 | dephosphorylation | down-regulates activity | 0.2 | We also identified EVI1 phosphorylation sites by MS analysis and showed that Ser538 and Ser858 can be phosphorylated and dephosphorylated by two EVI1 interactome proteins, casein kinase II and protein phosphatase-1α. Finally, mutations that impair EVI1 phosphorylation at these sites reduced EVI1 DNA binding through its... | SIGNOR-273430 |
P23469 | P06213 | 1 | dephosphorylation | down-regulates activity | 0.285 | In this study, we showed that receptor-type PTPepsilon (PTP epsilonM) dephosphorylated IR in rat primary hepatocytes and tyrosines 972, 1158, 1162 and 1163| These results suggest that PTPepsilonM is a negative regulator of IR signaling and involved in insulin-induced glucose metabolism mainly through direct dephosphory... | SIGNOR-248444 |
P17612 | Q9HC16 | 1 | phosphorylation | up-regulates | 0.324 | Here we show that pka binds and specifically phosphorylates a3g at thr32 in vitro and in vivo. This phosphorylation event reduces the binding of a3g to vif and its subsequent ubiquitination and degradation, and thus promotes a3g antiviral activity. | SIGNOR-181526 |
Q9HAU4 | P51668 | 1 | ubiquitination | up-regulates activity | 0.702 | Our data further show that SMURF2 monoubiquitinates UBCH5 at lysine 144 to form an active complex required for efficient degradation of a RAS family E3, beta transducing repeat containing protein 1 (beta-TrCP1). | SIGNOR-278718 |
P06493 | P04637 | 1 | phosphorylation | up-regulates activity | 0.579 | The N-terminus of E2F1 can interact directly with a region towards the C-terminus of p53, resulting in increased nuclear retention of p53 and p53-mediated transcription and apoptosis. This is inhibited by competition between p53 and cyclin A at the binding site within E2F19,10. The interaction between p53 and E2F1 is e... | SIGNOR-167779 |
Q03135 | P17096 | 1 | relocalization | up-regulates activity | 0.265 | CAV1 was shown to stimulate GLUT3 transcription via an HMGA1-binding site within the GLUT3 promoter. HMGA1 was found to interact with and activate the GLUT3 promoter and CAV1 increased the HMGA1 activity by enhancing its nuclear localization. | SIGNOR-254428 |
P20810 | P68400 | 0 | phosphorylation | up-regulates activity | 0.2 | We also showed that casein kinase 2, a pro-survival kinase overexpressed in many cancer types, phosphorylated calpastatin at Ser-633. Our results indicate that calpastatin phosphorylation promotes radiation resistance in GBM cells by increasing the activity of calpain proteases, which are known to promote survival and... | SIGNOR-277388 |
O00712 | O75093 | 1 | transcriptional regulation | up-regulates quantity | 0.249 | For example, within the NFI targetome, we identified 6 collagen genes, 13 genes encoding potassium channel or glutamate receptor subunits and a range of factors related to axon guidance (e.g. Slit1, Robo1, Epha4, Epha5, Epha8) | SIGNOR-268899 |
Q13153 | P21333 | 1 | phosphorylation | up-regulates | 0.789 | In flna, the pak1-binding site involves tandem repeat 23 in the carboxyl terminus and phosphorylation takes place on serine 2152. | SIGNOR-92065 |
Q16539 | P41970 | 1 | phosphorylation | up-regulates | 0.379 | Tcf sap-1a is efficiently phosphorylated by p38 map kinase in vitro and in vivo on the homologous residues ser381 and ser387. Mutation of these sites to alanine severely reduces c-fos sre-dependent transcription mediated by sap-1a and p38 map kinase. | SIGNOR-47685 |
P15498 | P29350 | 0 | dephosphorylation | down-regulates activity | 0.576 | SHP-1 dephosphorylates and inactivates the guanine exchange factor Vav1. | SIGNOR-277171 |
Q13131 | P14859 | 1 | phosphorylation | down-regulates | 0.2 | Mitosis-specific phosphorylation site in the homeodomain of oct-1 was phosphorylated in vitro by protein kinase a. Pka-mediated phosphorylation event was identified in the cns-specific pou domain protein brn-2/n-oct-3/pou3f2 (nieto et al. 2007). In this case, the modification, at a position homologous to oct1 s385, was... | SIGNOR-53254 |
P48729 | P10071 | 1 | phosphorylation | down-regulates | 0.6 | In principle, pka, ck-1 and gsk3 can phosphorylate as many as 19 serine residues in gli3: fourpkasites, three primarygsk3sites, four primary ck-1 sites and eight secondary gsk3 and ck-1 sites | SIGNOR-116512 |
O76061 | Q16665 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.297 | With the ChIP assay, we demonstrated the direct binding of HIF-1alpha to STC2 promoter. These findings support the notion that HIF-1 is a potent stimulator of STC2 expression. Collectively, this is the first report to show that STC2 was aberrantly hypermethylated in human cancer cells. The findings demonstrated that ST... | SIGNOR-260389 |
P54868 | Q9NXA8 | 0 | post translational modification | up-regulates activity | 0.343 | We demonstrate that SIRT5 regu-lates succinylation of the rate-limiting ketogenicenzyme 3-hydroxy-3-methylglutaryl-CoA synthase 2(HMGCS2) both in vivo and in vitro.|Succinylation of Lysine Residues within the SubstrateBinding Pocket Inhibits HMGCS2 Activity|Here, we use a label-freequantitative proteomic approach to ch... | SIGNOR-267641 |
P31749 | P07949 | 0 | phosphorylation | up-regulates | 0.323 | The PKB Y315 residue, which is known to be phosphorylated by Src tyrosine kinase, was also a major site of phosphorylation by RET/PTC. RET/PTC-mediated tyrosine phosphorylation results in the activation of PKB kinase activity | SIGNOR-252619 |
P55283 | P07737 | 0 | null | up-regulates activity | 0.335 | Taken together, data obtained from MCF10A cells were consistent with the idea that Rho signaling to Dia1 and profilin-1 was essential for R-cadherin adherens junction formation. | SIGNOR-253111 |
Q14680 | O15530 | 1 | phosphorylation | down-regulates activity | 0.267 | The results showed that MPK38 interacted with and inhibited PDK1 activity via Thr(354) phosphorylation. | SIGNOR-276414 |
Q92529 | Q15303 | 0 | relocalization | up-regulates | 0.497 | Like erbb1, erbb4 recruits grb2, shc and stat5. | SIGNOR-147850 |
Q06124 | Q13224 | 1 | dephosphorylation | down-regulates activity | 0.469 | In addition, surface expression of GluN2B was not reduced in mutant mice and it remains to be investigated how the direct dephosphorylation of GluN2B Y1252 by Shp2 reduces GluN2B function.|The increased GluN2B Y1472 phosphorylation was reversed by a Src family kinase inhibitor, suggesting that Shp2 may negatively regul... | SIGNOR-276950 |
P45984 | P45983 | 0 | phosphorylation | up-regulates | 0.593 | Our studies revealed a novel mechanism in which phosphorylation of jnk2 is mediated by jnk1 before phosphorylation of p53, and then p53 is directly phosphorylated by jnk2 at ser6. | SIGNOR-155205 |
Q92934 | P23443 | 0 | phosphorylation | down-regulates activity | 0.295 | P70S6K, the downstream target of mTORC1, can phosphorylate and inactivate pro apoptotic BAD by producing a reaction that disrupts BAD 's binding to other pro apoptotic molecules thereby allowing cell survival.|p70S6K, the downstream target of mTORC1, can phosphorylate and inactivate pro-apoptotic BAD by producing a rea... | SIGNOR-280016 |
P01106 | P38936 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.779 | C-myc also directly represses transcription of cdk kinase inhibitors including p27kip1, p21cip1, p15ink4b and p16ink4a | SIGNOR-102740 |
Q13526 | P45983 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.272 | Mechanistically, the JNK kinases directly bind to and phosphorylate PIN1 at Ser115, and this phosphorylation prevents PIN1 mono-ubiquitination at Lys117 and its proteasomal degradation. | SIGNOR-277562 |
Q9BPZ3 | O95071 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.445 | We demonstrate a mechanism for this co-regulation that involves an E3 ubiquitin ligase, EDD, which targets Paip2 for degradation. PABP depletion by RNA interference (RNAi) causes co-depletion of Paip2 protein without affecting Paip2 mRNA levels. Upon PABP knockdown, Paip2 interacts with EDD, which leads to Paip2 ubiqui... | SIGNOR-272648 |
O75116 | Q96A00 | 1 | phosphorylation | up-regulates activity | 0.413 | A major kinase for GPCR‐induced CPI‐17 phosphorylation is PKC which is activated by the PLCbeta‐produced signaling messenger diacylglycerol (DAG). It phosphorylates CPI‐17 at Thr38 residue that directly docks at the active site of MLCP, thereby inhibiting its activity and promoting an increase of phosphorylation of myo... | SIGNOR-96696 |
P40429 | O43293 | 0 | phosphorylation | up-regulates | 0.402 | Zipk phosphorylates l13a in vitro / l13a is phosphorylated on ser77 in vitro | SIGNOR-182117 |
Q16539 | O95382 | 0 | phosphorylation | up-regulates activity | 0.2 | These data indicate that MKK6 phosphorylates p38 MAP kinase on Thr-180 and Tyr-182, the sites of phosphorylation that activate p38 MAP kinase | SIGNOR-260916 |
P10275 | O75592 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | We identified several E3 ligases as strong candidates responsible for AR and MYC protein loss as HECTD4, MYCBP2, and TRIM49. HECTD4 and MYCBP2 target AR and MYC for degradation while TRIM49 appears to promote AR and MYC stability. We have shown that these E3 ligases in turn are directly regulated by MYC. MYC in turn r... | SIGNOR-267149 |
Q14118 | Q12955 | 0 | relocalization | up-regulates quantity | 0.259 | We present evidence for an ankyrin-based mechanism for sarcolemmal localization of dystrophin and beta-DG. Ankyrin-B thus is an adaptor required for sarcolemmal localization of dystrophin, as well as dynactin-4. | SIGNOR-266714 |
Q96EP5 | P28482 | 0 | phosphorylation | down-regulates activity | 0.2 | Further experiments showed that DAZAP1 was phosphorylated stoichiometrically in vitro by ERK2 (extracellular-signal-regulated protein kinase 2) at two Thr-Pro sequences (Thr269 and Thr315), and that both sites became phosphorylated in HEK-293 (human embryonic kidney 293) cells in response to PMA or EGF (epidermal growt... | SIGNOR-262970 |
O14522 | P40763 | 1 | dephosphorylation | down-regulates activity | 0.516 | Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T|Phosphorylation of a tyrosine at amino acid Y705 is essential for the function of STAT3, and PTPRT specifically dephosphorylated STAT3 at this position. | SIGNOR-263981 |
Q99684 | P49841 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.2 | GSK3β-mediated GFI1 S94/S98 phosphorylation triggered its interaction with FBXW7, resulting in SCFFBXW7-mediated ubiquitination and degradation. | SIGNOR-277465 |
Q06124 | P12235 | 1 | dephosphorylation | down-regulates activity | 0.271 | Specifically, SHP2-mediated dephosphorylation of ANT1 at Tyr 191 is essential for mitochondrial homeostasis and mitigation of NLRP3 inflammasome activation.|The interaction between SHP2 and ANT1 (Fig.\u00a0 xref ), and the opposite effects of SHP2 and ANT1 shRNAs in the activation of NLRP3 inflammasome (Figs.\u00a0 xre... | SIGNOR-277124 |
Q969H0 | O00141 | 0 | phosphorylation | up-regulates | 0.291 | Here, we report that the serum- and glucocorticoid-inducible protein kinase sgk1 remarkably reduced the protein stability of the active form of notch1 through fbw7activated sgk1 phosphorylated fbw7 at serine 227 | SIGNOR-170404 |
P49841 | Q6NZ36 | 1 | phosphorylation | down-regulates quantity | 0.2 | Furthermore, GSK3beta was able to decrease the cellular FAAP20 levels when overexpressed in wild-type, but not in FBW7 -/- HCT116 cells, indicating that GSK3beta requires downstream FBW7 to regulate the FAAP20 stability.|GSK3\u03b2 phosphorylates FAAP20 at Ser113. | SIGNOR-279048 |
Q03393 | Q13976 | 0 | phosphorylation | up-regulates | 0.257 | Upon expression in cos-1 cells, ptps-s19a was stable but not phosphorylated and had a reduced activity of approximately 33% in comparison to wild-type ptps. Addition of cgmp stimulated phosphotransferase activity 2-fold. Extracts from transfected cos-1 cells overexpressing cgkii stimulated ser(19) phosphorylation more ... | SIGNOR-71680 |
O75807 | P35638 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.454 | ATF4 also induces another bZIP protein C/EBP-homologous protein (CHOP), which is responsible for triggering apoptosis in cells under prolonged ER stress. ATF4 and CHOP further induce growth arrest and DNA damage–inducible protein 34 (GADD34),a regulatory subunit of protein phosphatase 1 (PP1) that dephosphorylates eIF2... | SIGNOR-260173 |
P68400 | Q6ZMG9 | 1 | phosphorylation | up-regulates activity | 0.2 | Most of the phosphorylated residues conformed to a consensus motif for phosphorylation by casein kinase 2 (CK2), and treatment of cells with the CK2-specific inhibitor CX-4945 lowered the phosphorylation levels of CERS2, -4, -5, and -6. Phosphorylation of CERS2 was especially important for its catalytic activity, actin... | SIGNOR-273992 |
Q9UQL6 | P34947 | 0 | phosphorylation | down-regulates activity | 0.356 | GRK5 phosphorylates and promotes the nuclear export of the histone deacetylase, HDAC5. | SIGNOR-279045 |
Q96NY9 | P68400 | 0 | phosphorylation | up-regulates activity | 0.2 | Here, we show that the CK2 kinase phosphorylates MUS81 at Serine 87 in late-G2/mitosis, and upon mild replication stress. Phosphorylated MUS81 interacts with SLX4, and this association promotes the function of the MUS81 complex. | SIGNOR-273626 |
Q6NXT2 | Q92831 | 0 | acetylation | down-regulates activity | 0.2 | The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. | SIGNOR-269617 |
P46019 | P17612 | 0 | phosphorylation | down-regulates activity | 0.325 | Phosphorylation of the alpha and beta subunits by the 3',5'-cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) also relieves inhibition of the gamma subunit and thereby activates the enzyme. | SIGNOR-267410 |
P43405 | P37840 | 1 | phosphorylation | down-regulates | 0.532 | Here, we show that alpha-synuclein (alpha-syn) is an outstanding substrate for the protein tyrosine kinase p72syk (syk), which phosphorylates three tyrosyl residues in its c-terminal domain (y-125, y-133, and y-136), here, we show that _-syn is an outstanding substrate for syk and that once it is tyrosine phosphorylat... | SIGNOR-113065 |
O00571 | Q9UHD2 | 0 | phosphorylation | up-regulates activity | 0.721 | Coexpression of TBK1 strongly increased the activity of DDX3X.|This suggests that DDX3X is rather specifically phosphorylated by TBK1 and IKK-i. | SIGNOR-278997 |
Q6ZNA4 | P61956 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.626 | Arkadia ubiquitinates poly-SUMO2 chains in a SIM- and RING-dependent manner. | SIGNOR-272882 |
Q15418 | Q07352 | 1 | phosphorylation | down-regulates activity | 0.2 | These results indicate that RSK1 directly phosphorylates the C-terminus of ZFP36L1 downstream of ERK, and inhibits the Messenger RNA destabilization activity of ZFP36L1.|These results indicate that RSK1 directly phosphorylates the C-terminus of ZFP36L1 downstream of ERK, and inhibits the mRNA destabilization activity o... | SIGNOR-279280 |
P18031 | P09619 | 1 | dephosphorylation | down-regulates | 0.691 | Ptp1b blocked pdgf-induced tyr716 and tyr751 phosphorylation of the pdgfr. | SIGNOR-179064 |
P51955 | Q15154 | 0 | relocalization | up-regulates | 0.425 | Recruitment of nek2 and c-nap1 to the centrosome is dependent on pcm-1 | SIGNOR-133337 |
Q05655 | P45983 | 1 | phosphorylation | up-regulates | 0.501 | By contrast, after uv stimulation, rela directly induces the expression of pkcdelta, which in turn activates jnk. | SIGNOR-151428 |
Q15417 | Q06187 | 0 | phosphorylation | up-regulates quantity | 0.2 | Co-expression of calponin-3 with various kinases in S2 Schneider cells promoted a phosphorylation of calponin-3 by Syk, but also by the Tec family kinase Btk. | SIGNOR-280196 |
P08575 | P19784 | 0 | phosphorylation | up-regulates activity | 0.434 | Mutational analysis of CK2 consensus sites showed that the target for CK2 was in an acidic insert of 19 amino acids in the D2 domain, and Ser to Ala mutations at amino acids 965, 968, 969, and 973 abrogated CK2 phosphorylation of CD45. CK2 phosphorylation increased CD45 activity 3-fold toward phosphorylated myelin basi... | SIGNOR-251031 |
O00141 | Q96J92 | 1 | phosphorylation | up-regulates activity | 0.415 | In addition, we identified a novel SGK1 phosphorylation site (S1201) in WNK4, and phosphorylation at this site is reduced by Ca(2+)/CaM. | SIGNOR-276421 |
P49841 | P24864 | 1 | phosphorylation | down-regulates | 0.445 | Our experiments suggest that gsk3 is the kinase primarily responsible for phosphorylation of cyclin e on t380 | SIGNOR-118563 |
P53539 | P59595 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | The transcription factors c-Fos, FosB, CREB-1, and ATF2 were all activated by the addition of SARS-CoV N protein to the sample well | SIGNOR-260728 |
Q14258 | Q969H0 | 1 | ubiquitination | down-regulates activity | 0.264 | This newly stabilized TRIM25 then directly ubiquitinates Lys412 of FBXW7α, a core subunit of the SKP1-Cullin-F-box (SCF) ubiquitin ligase complex involved in Myc ubiquitination, thereby stabilizing Myc. | SIGNOR-277457 |
Q14164 | P35813 | 0 | dephosphorylation | down-regulates activity | 0.279 | PPM1A directly dephosphorylates both MAVS and TBK1 and IKKepsilon.|In a similar in vitro phosphatase assay, incubation of PPM1A also eliminated TBK1 and IKKepsilon phosphorylation at Ser 172 residue, evidenced by phospho-S172 immunoblotting (XREF_FIG, F and G).|These observations suggest that PPM1A may block kinase act... | SIGNOR-277072 |
P18848 | O95750 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | Reporter gene analyses using the 5'-promoter region of FGF19 revealed that a functional AARE (amino-acid-response element) was localized in this region, and this site was responsible for inducing its transcription through ATF4 (activating transcription factor 4), which is activated in response to ER stress | SIGNOR-253727 |
P35568 | Q9H0K1 | 0 | phosphorylation | down-regulates quantity | 0.567 | SIK2 is known to attenuate insulin signaling by phosphorylating IRS-1/Ser789 | SIGNOR-265745 |
Q13131 | Q9UQL6 | 1 | phosphorylation | down-regulates | 0.341 | Another recently described set of transcriptional regulators targeted by ampk and its related family members across a range of eukaryotes are the class iia family of histone deacetylases (hdacs) | SIGNOR-176479 |
P17612 | P32245 | 1 | phosphorylation | down-regulates activity | 0.308 | Activation of MC4R by agonist is associated with protein kinase A (PKA) and GRK phosphorylation of serine/threonine residues in the C-terminal tail of MC4R, followed by -arrestin and dynamin-dependent internalization of the receptor. Thr312 and Ser329/330 in the C-terminal tail of MC4R are potential sites for PKA | SIGNOR-250016 |
P35226 | P16104 | 1 | ubiquitination | up-regulates activity | 0.2 | In this process, BMI1 ubiquitinates histone H2A and \u03b3H2AX, thereby facilitating the repair of double-stranded DNA breaks through stimulating homologous recombination and non-homologous end joining. | SIGNOR-278744 |
Q13131 | P08559 | 1 | phosphorylation | up-regulates activity | 0.2 | AMPKα phosphorylates PDHA subunit on Ser295 and Ser314 to activate PDH complex | SIGNOR-276837 |
O00303 | P21127 | 0 | phosphorylation | up-regulates activity | 0.515 | EIF3f is phosphorylated by CDK11p46 at Ser46 during apoptosis.|Phosphorylation of eIF3f plays an important role in regulating its function in translation and apoptosis. Phosphorylation of eIF3f enhances the association of eIF3f with the core eIF3 subunits during apoptosis. | SIGNOR-273133 |
Q9H3R0 | Q99814 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | To this end, we confirm that KDM3A, KDM4B, KDM4C, KDM5B, KDM5C, and KDM62 are direct targets of HIF-1a while extent the list of known targets to KDM2A, KDM2B, KDM4D, KDM5A, and KDM6A. The results demonstrated that majority of the KDMs were similarly induced (KDM2A, KDM2B, KDM3A, KDM4B, KDM4C, KDM4D, KDM5A, KDM5B, KDM5C... | SIGNOR-271585 |
P08581 | P49841 | 1 | phosphorylation | up-regulates activity | 0.308 | MET phosphorylated and activated GSK3B at tyrosine 56, which decreased the expression of PDL1 by liver cancer cells. | SIGNOR-277428 |
P51151 | Q7Z6M1 | 1 | null | up-regulates activity | 0.581 | P40 is a very potent transport factor in that the pure, recombinant protein can stimulate, significantly, an in vitro transport assay that measures transport of mannose 6-phosphate receptors from endosomes to the trans-Golgi network. The functional importance of p40 is confirmed by the finding that anti-p40 antibodies ... | SIGNOR-253088 |
O60674 | O14744 | 1 | phosphorylation | down-regulates | 0.693 | Oncogenic jak2 kinases phosphorylate prmt5 in_vivo phosphorylation of prmt5 by jak2v617f greatly impairs its methyltransferase activity | SIGNOR-171994 |
Q03112 | Q15389 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | We finally observed that the forced expression of Evi1 induced GATA-2 expression in a hematopoietic cell line, EML C1, along with GATA-1, Ang-1, Ang-2 and Tie2 | SIGNOR-266059 |
O14950 | Q13464 | 0 | phosphorylation | up-regulates | 0.624 | Here we found that rho-kinase has an activity for mrlc diphosphorylation at both threonine 18 and serine 19 in nonmuscle cells using sequential column chromatographies. | SIGNOR-91542 |
Q15058 | Q8TDX7 | 0 | phosphorylation | up-regulates activity | 0.371 | Nek7 direct phosphorylation is required for the anaphase localization of Kif14. we generated an EGFP-Kif14-5A construct in which Ser56, Ser607, Ser1217, Ser1219, and Ser1220 were all mutated to Ala. When transfected into HeLa cells, EGFP-Kif14-5A was expressed to similar levels as WT Kif14 (Fig. S3 C), but its localiza... | SIGNOR-266420 |
O43683 | Q96GD4 | 0 | phosphorylation | up-regulates activity | 0.749 | Although our analysis identified only one of the 15 sites implicated in Bub1-Mad1 interaction, it suggests that following its rapamycin-induced dimerization, Ipl1 phosphorylates Bub1, and potentially Mad1, to drive eSAC signaling. | SIGNOR-279010 |
P03951 | P00740 | 1 | cleavage | up-regulates activity | 0.484 | Factor XI (FXI) is the zymogen of an enzyme (FXIa) that contributes to hemostasis by activating factor IX.|The characterization of the apple disk structure, and its relationship to the catalytic domain, have provided new insight into the mechanism of FXI activation, the interaction of FXIa with the substrate factor IX,... | SIGNOR-263537 |
P09493 | P53355 | 0 | phosphorylation | up-regulates activity | 0.277 | We identified, for the first time, death-associated protein kinase 1 (DAP kinase 1) as the kinase that phosphorylates tropomyosin-1 in response to ERK activation by hydrogen peroxide (H(2)O(2)). We also report that the phosphorylation of tropomyosin-1 mediated by DAP kinase occurs on Ser283. Our finding that tropomyos... | SIGNOR-262845 |
P01111 | Q8TEU7 | 0 | guanine nucleotide exchange factor | up-regulates | 0.331 | Gefs catalyse the transition from gdp-bound, inactive ras to gtp-bound, active ras. | SIGNOR-183799 |
P43405 | Q9GZY6 | 1 | phosphorylation | up-regulates activity | 0.592 | Our results indicated that human LAB was primarily phosphorylated on three membrane-distal tyrosines, Tyr(136), Tyr(193), and Tyr(233). Mutation of these three tyrosines abolished Grb2 binding and LAB function. Our data suggested that these tyrosines are the most important tyrosines for LAB function.The dramatic reduct... | SIGNOR-273576 |
O75962 | P63000 | 1 | guanine nucleotide exchange factor | up-regulates activity | 0.692 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260579 |
P11362 | Q96QU1 | 1 | phosphorylation | up-regulates activity | 0.2 | FGFR1 mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia.|We find that on activation, FGFR1 binds and phosphorylates Pcdh15. | SIGNOR-280014 |
P00533 | P40763 | 1 | phosphorylation | up-regulates activity | 0.879 | The transcription factors stat1, stat3, and stat5 are directly phosphorylated by erbb-1, subsequent to which they dimerize through phosphotyrosine-sh2 domain interactions and translocate to the nucleus to activate gene trascription critical for proliferation. | SIGNOR-121965 |
Q14114 | Q05519 | 0 | post transcriptional regulation | up-regulates quantity by stabilization | 0.2 | We demonstrate that SFRS11 directly binds to the 3' UTR of LRP8 mRNA, as well as to the third exon of apoE mRNA, resulting in stabilization of these mRNAs, eventually deactivating JNK signaling. | SIGNOR-269670 |
Q13153 | Q7Z628 | 1 | phosphorylation | down-regulates activity | 0.249 | In this work we show that the Rac/Cdc42hs-regulated protein kinase PAK1 down-regulates the activity of the RhoA-specific guanine nucleotide exchange factor NET1. Specifically, PAK1 phosphorylates NET1 on three sites in vitro: serines 152, 153, and 538. Replacement of serines 152 and 153 with glutamate residues down-reg... | SIGNOR-263018 |
P27361 | P23467 | 0 | dephosphorylation | up-regulates | 0.432 | When cells are stimulated with various ligands such as growth factors, hormones, neurotransmitters, or tumor promoters, erk1/2 is activated through dualphosphorylation at the -ptepy-motif. Subsequently, p-erk1/2 translocates into the nucleus and phosphorylates elk-1, thereby acting as a transcription factor for cell pr... | SIGNOR-103165 |
Q9Y2K7 | Q99814 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | To this end, we confirm that KDM3A, KDM4B, KDM4C, KDM5B, KDM5C, and KDM62 are direct targets of HIF-1a while extent the list of known targets to KDM2A, KDM2B, KDM4D, KDM5A, and KDM6A. The results demonstrated that majority of the KDMs were similarly induced (KDM2A, KDM2B, KDM3A, KDM4B, KDM4C, KDM4D, KDM5A, KDM5B, KDM5C... | SIGNOR-271581 |
Q05513 | P49841 | 1 | phosphorylation | down-regulates | 0.597 | Phospho-gsk3b-specific antibodies also revolved that lkb1 regulates gsk3b phosphorylation at a known inhibitory site, serine-9. This localized phosphorylation is cdc42 and pkc-zeta-dependent. | SIGNOR-119889 |
P11802 | P07947 | 0 | phosphorylation | down-regulates | 0.254 | We purified tyrosine 17 kinases from hela cells and found that the src family non-receptor tyrosine kinase c-yes contributes a large fraction of the tyrosine 17 kinase activity in hela lysatesthis site is equivalent to tyrosine 15 of cyclin dependent kinase 1, which undergoes inhibitory phosphorylation by wee1 and myt1 | SIGNOR-178624 |
Q7L5N7 | P49137 | 0 | phosphorylation | up-regulates activity | 0.2 | Mass spectrometry and mutagenesis analyses identified Ser34 of LPCAT2 as the phosphorylation site to enhance the catalytic activities. The experiments using inhibitors and siRNA against MAPK cascades demonstrated that LPCAT2 phosphorylation through LPS-TLR4 signaling may directly depend on MAPK-activated protein kinase... | SIGNOR-263077 |
P25098 | Q13304 | 1 | phosphorylation | down-regulates activity | 0.2 | As depicted in Fig. 8 A and B, GRK2 silencing resulted in up-regulation of GPR17 and down-regulation of the mature markers CNPase and MBP, indicating a shift of cells toward a less differentiated stage.Having established that, in primary cultured OPCs, LTD 4 mediated desensitization of GPR17 through the primary recruit... | SIGNOR-279999 |
P53990 | Q9UBP0 | 1 | relocalization | up-regulates activity | 0.519 | Our results suggest that inclusion of IST1 into the ESCRT complex allows recruitment of spastin to promote fission of recycling tubules from the endosome. Thus, we reveal a novel cellular role for MT severing and identify a mechanism by which endosomal recycling can be coordinated with the degradative machinery. | SIGNOR-269047 |
P17612 | O76054 | 1 | phosphorylation | up-regulates activity | 0.2 | These results suggest that phosphorylation of SPF by PKA is a dynamic process and that, in the absence of PKA activity, SPF is rapidly inactivated.Thus, phosphorylation of SPF at Ser-289 appears necessary for maximal stimulation of squalene monooxygenase activity in vitro and absolutely required for the stimulation of ... | SIGNOR-276027 |
Q09472 | P15172 | 1 | acetylation | up-regulates | 0.681 | Our results provide direct evidence that myod acetylation functionally activates the protein and show that both pcaf and cbp/p300 are candidate enzymes for myod acetylation in vivo. | SIGNOR-81053 |
P12931 | Q8IXH7 | 1 | phosphorylation | down-regulates activity | 0.336 | Here we show that c-Src interacts with TH1 by GST-pull down assay, coimmunoprecipitation and confocal microscopy assay. The interaction leads to phosphorylation of TH1 at Tyr-6 in vivo and in vitro. Phosphorylation of TH1 decreases its association with A-Raf and PAK1. | SIGNOR-276402 |
Q04912 | P00519 | 1 | phosphorylation | up-regulates activity | 0.272 | This suggests that by interacting with Sdc4, either directly or indirectly, RON is activated via transphosphorylation when clustered, engages the ABL1 SH2 domain, and activates ABL1 by phosphorylation. | SIGNOR-272999 |
P19419 | P45984 | 0 | phosphorylation | up-regulates activity | 0.49 | However, both of these stimuli strongly activate two other mapks, jnk1 and jnk2, and stimulate elk-1 transcriptional activity and phosphorylation jnk phosphorylation sites include ser383 and ser389, the major residues whose phosphorylation is responsible for enhancement of elk-1 trascriptional activity. | SIGNOR-247062 |
Q16539 | Q14814 | 1 | phosphorylation | up-regulates activity | 0.612 | Targeting of ash2l to specific genes is mediated by the transcriptional regulator mef2d. Furthermore, this interaction is modulated during differentiation through activation of the p38 mapk signaling pathway via phosphorylation of mef2d. | SIGNOR-159331 |
Q15910 | Q9C0B5 | 0 | palmitoylation | down-regulates activity | 0.2 | Mechanistic investigations revealed that mutant p53 transcriptionally upregulated ZDHHC5 along with the nuclear transcription factor NF-Y. These events contributed to the development of glioma by promoting the self-renewal capacity and tumorigenicity of glioma stem-like cells, by altering the palmitoylation and phospho... | SIGNOR-261144 |
Q05397 | P51813 | 0 | phosphorylation | up-regulates | 0.551 | Bmx phosphorylated focal adhesion kinase (fak) at tyr577 subsequent to its src-mediated phosphorylation at tyr576. Loss of bmx by rna interference or by genetic deletion in mouse embryonic fibroblasts (mefs) markedly impaired fak activity. | SIGNOR-202139 |
Q13233 | O14733 | 1 | phosphorylation | up-regulates | 0.723 | Here we show that jnkk2, a novel member of the map kinase kinase family, was phosphorylated and activated by mekk1 | SIGNOR-51207 |
P10721 | Q5JUK2 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.346 | Our results suggest that SOHLH1 and SOHLH2 directly stimulate Kit transcription in postnatal spermatogonia, thus activating the signaling involved in spermatogonia differentiation and spermatogenetic progression. | SIGNOR-266205 |
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