IdA string | IdB string | labels int64 | mechanism string | effect string | score float64 | sentence string | signor_id string |
|---|---|---|---|---|---|---|---|
Q7KZI7 | P46939 | 1 | phosphorylation | up-regulates | 0.424 | Par-1b, interacts with the utrophin-dg complex, and positively regulates the interaction between utrophin and dg. Ser1258 within r9 is specifically phosphorylated by par-1b. | SIGNOR-161915 |
P35372 | P25098 | 0 | phosphorylation | down-regulates activity | 0.2 | These results suggest that two C-terminal amino acids, Ser(355) and Thr(357), are required for short-term homologous desensitization and agonist-induced phosphorylation of mu-opioid receptors expressed in HEK 293 cells | SIGNOR-249661 |
P28482 | Q08499-2 | 1 | phosphorylation | down-regulates | 0.353 | The pde4d2 isoform is inhibited by erk2 phosphorylation | SIGNOR-77563 |
P78347 | P12931 | 0 | phosphorylation | up-regulates activity | 0.453 | C-Src-dependent transcriptional activation of TFII-ITFII-I is a multifunctional transcription factor that is also involved in signal transduction. Here we show that TFII-I undergoes a c-Src-dependent tyrosine phosphorylation on tyrosine residues 248 and 611 and translocates to the nucleus in response to growth factor s... | SIGNOR-247189 |
O75122 | P00519 | 0 | phosphorylation | up-regulates quantity | 0.502 | We find that Abl binds to and phosphorylates CLASP2 in response to extracellular signals such as serum or PDGF. | SIGNOR-279580 |
Q07352 | P31749 | 0 | phosphorylation | down-regulates | 0.657 | Here we report that protein kinase b (pkb/akt) stabilizes are transcripts by phosphorylating brf1 at serine 92 (s92). Recombinant brf1 promoted in vitro decay of are-containing mrna (are-mrna), yet phosphorylation by pkb impaired this activity. | SIGNOR-130376 |
P18848 | P49591 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | QRICH1 promotes the expression of translation-related genes. our combined ChIP-seq and RNA-seq analyses identified that QRICH1 and ATF4 were enriched at the promoters of these specific tRNA synthetases, and that ER stress positively regulated their transcription (Fig. 4I). Together, these findings suggest that QRICH1 a... | SIGNOR-269424 |
P03372 | P68400 | 0 | phosphorylation | down-regulates | 0.246 | Additionally protein kinase ck2 was identified as a kinase that phosphorylated eralpha at s282 and s559 s282 and s559 represent the second and third sites of er_ regulation by ck2. Remarkably, mutation of s282 or s559 to alanine resulted in near opposite functional effects on er_ as compared to mutation of s167 to alan... | SIGNOR-162653 |
P24941 | P17676 | 1 | phosphorylation | up-regulates | 0.395 | Mass spectrometric analysis revealed that cdk2/cyclina phosphorylates c/ebpbeta on thr(188) and is required for phosphorylation (on ser(184) or thr(179)) of c/ebpbeta by gsk3beta and maintenance of dna binding activity. | SIGNOR-196372 |
Q9BQE3 | Q5SQI0 | 0 | acetylation | up-regulates quantity by stabilization | 0.246 | Alpha-Tubulin acetyltransferase (alphaTAT1) is the major α-tubulin lysine-40 (K40) acetyltransferase in mammals, nematodes, and protozoa, and its activity plays a conserved role in several microtubule-based processes.|The tubulin subunits of microtubules are acetylated, and lysine-40 (K40) of the alpha-tubulin subunit ... | SIGNOR-272247 |
P05771 | O75144 | 1 | phosphorylation | up-regulates activity | 0.2 | PKCα and PKCβ are required for phosphorylation of ICOSL and ICOSL-mediated cytokine induction | SIGNOR-273797 |
Q03933 | Q13618 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.326 | Here we show that the PEST sequences of a short-lived protein called HSF2 interact with Cullin3, a subunit of a Cullin-RING E3 ubiquitin ligase, and that this interaction mediates the Cul3-dependent ubiquitination and degradation of HSF2 | SIGNOR-239129 |
Q13131 | P17252 | 0 | phosphorylation | down-regulates activity | 0.2 | Purified PKC and Akt both phosphorylated AMPKα1 Ser487 in vitro with similar efficiency. PKC activation was associated with reduced AMPK activity, as inhibition of PKC increased AMPK activity and phorbol esters inhibited AMPK, an effect lost in cells expressing mutant AMPKα1 Ser487Ala. Consistent with a pathophysiologi... | SIGNOR-276459 |
P00533 | Q9NY28 | 0 | glycosylation | down-regulates activity | 0.2 | Interestingly, the O-GalNAcylation of EGFR, which is the key factor related to the metastasis cascade, was impacted by GALNT8. Furthermore, our results suggested that the GALNT8-mediated O-GalNAcylation led to the suppression of the EGFR signaling pathway and metastatic potential in breast cancer cells. | SIGNOR-269679 |
P04035 | P17612 | 0 | phosphorylation | down-regulates activity | 0.333 | The intact, 100 kd microsomal enzyme and the 53 kd catalytic fragment of rat HMG-CoA reductase are both phosphorylated and inactivated by the AMP-activated protein kinase. this site is highly phosphorylated in intact liver under these conditions (Ser872 in the human enzyme). | SIGNOR-249992 |
Q99717 | O96004 | 1 | transcriptional regulation | up-regulates quantity | 0.2 | Chromatin immunoprecipitation (ChIP) revealed a subset of the BIG (BMP4 induced genes) signature, including Satb2, Smad6, Hand1, Gadd45γ and Gata3, that was bound by Smad1/5 in the developing mandible, revealing direct Smad-mediated regulation | SIGNOR-268941 |
Q6PJ69 | Q96P20 | 1 | ubiquitination | down-regulates activity | 0.2 | These results suggest that TRIM65 could inhibit the activation of the NLRP3 inflammasome in response to multiple agonists.|Thus, TRIM65 deficiency impairs NLRP3 ubiquitination and enhances NLRP3 inflammasome activation, but has no effects on AIM2 or IPAF inflammasome activation. | SIGNOR-278566 |
P78352 | Q12879 | 1 | relocalization | up-regulates activity | 0.811 | The PDZ domains of PSD-95 and related proteins interact with the COOH-terminal sequences of K+channels and NMDA2 receptors (3). By these interactions, PSD-95 may mediate the clustering of K+ channels and NMDA receptors at synapses. | SIGNOR-264194 |
P19544 | P49841 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.284 | Glycogen synthase kinase 3β promoted phosphorylation of cugWT1 at S64, resulting in ubiquitination and degradation of the cugWT1 associated with the F-box-/- WD repeat-containing protein 8. | SIGNOR-277540 |
P11308 | P30291 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.2 | Here, we demonstrate that DNA damage induces proteasomal degradation of wild-type ERG and TMPRSS2-ERG oncoprotein through ERG threonine-187 and tyrosine-190 phosphorylation mediated by GSK3β and WEE1, respectively. | SIGNOR-277529 |
Q9Y3D6 | Q9NX47 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | MITOL associates with and ubiquitinates mitochondrial fission protein hFis1. (A) Ubiquitination of hFis1 by MITOL. Thus, MITOL may control the protein expression level of hFis1 through the ubiquitin–proteasome pathway. | SIGNOR-274141 |
Q13363 | Q9H2X6 | 0 | phosphorylation | down-regulates | 0.47 | Homeodomain-interacting protein kinase-2 mediates ctbp phosphorylation and degradation in uv-triggered apoptosishipk2 phosphorylates ctbp at ser-422 | SIGNOR-134040 |
Q13882 | Q99704 | 1 | phosphorylation | down-regulates activity | 0.494 | BRK downregulates Dok1 via proteasomal degradation.|BRK phosphorylates Dok1 at tyrosine 362. | SIGNOR-278301 |
P41143 | P25098 | 0 | phosphorylation | down-regulates activity | 0.2 | Taken together, we have demonstrated that agonist-induced opioid receptor phosphorylation occurs exclusively at two phosphate acceptor sites (T358 and S363) of GRK2 at the DOR carboxyl terminus. | SIGNOR-249660 |
P01222 | P01137 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.2 | TGF-β inhibits thyroid-stimulated hormone (TSH)-induced NIS mRNA and protein levels in a dose-dependent manner. This effect takes place at the transcriptional level, as TGF-β inhibits TSH-induced transcription | SIGNOR-251991 |
Q92858 | Q7Z6Z7 | 0 | ubiquitination | down-regulates quantity | 0.304 | Huwe1 ubiquitinates and degrades Atoh1, and robustly affects development of GNPs that express this transcription factor [ xref ].|This provides further evidence that phosphorylation of Atoh1 affects Huwe1-mediated degradation, and demonstrates that Huwe1 inhibits Atoh1 to affect cellular differentiation in multiple cel... | SIGNOR-278693 |
Q9BUB5 | Q16539 | 0 | phosphorylation | up-regulates | 0.672 | Mnk1, but not mnk2, also binds strongly to the stress-activated kinase, p38. | SIGNOR-48346 |
Q05655 | P00519 | 0 | phosphorylation | up-regulates activity | 0.384 | Specifically, we have shown that nuclear targeting of PKCdelta is necessary and sufficient for epithelial cell apoptosis, and that nuclear translocation requires phosphorylation of PKCdelta at Y155 and Y64 by c-Abl and c-Src, respectively. | SIGNOR-279436 |
Q9NQG5 | Q96GD4 | 0 | phosphorylation | up-regulates activity | 0.2 | Mechanistically, we revealed that CREPT/RPRD1B interacted with Aurora B to regulate the expression of Cyclin B1 in gastric cancer cells. Interestingly, Aurora B phosphorylates S145 in a well-conserved motif of CREPT/RPRD1B. We proposed that phosphorylation of CREPT/RPRD1B by Aurora B is required for promoting the trans... | SIGNOR-265499 |
Q15139 | P12830 | 1 | phosphorylation | up-regulates | 0.451 | Our study has identified e-cadherin as a novel substrate of pkd1, and phosphorylation of e-cadherin by pkd1 is associated with increased cellular aggregation and decreased cellular motility in prostate cancer. | SIGNOR-133856 |
P46531 | Q96EB6 | 0 | deacetylation | down-regulates | 0.423 | The acetylation marks on notch1-icd are removed by the deacetylase sirt1, suggesting that both deacetylation of notch1-icd and of histones inhibit notch signaling. | SIGNOR-195333 |
P68400 | Q13541 | 1 | phosphorylation | down-regulates | 0.341 | Phosphorylation at s112 directly affects binding of 4e-bp1 to eif4e without influencing phosphorylation of other sites. | SIGNOR-98280 |
Q15796 | Q96J02 | 0 | ubiquitination | up-regulates | 0.453 | Itch promotes ubiquitination of smad2 and augments smad2 phosphorylation that requires an intact ligase activity of itch. Moreover, itch facilitates complex formation between tgf-beta receptor and smad2 and enhances tgf-beta-induced transcription. | SIGNOR-128647 |
P19367 | O75385 | 0 | phosphorylation | up-regulates activity | 0.257 | Here, we demonstrate that, during deprivation of amino acid and growth factors, ULK1/2 directly phosphorylate key glycolytic enzymes including hexokinase (HK), phosphofructokinase 1 (PFK1), enolase 1 (ENO1), and the gluconeogenic enzyme fructose-1,6-bisphosphatase (FBP1).Phosphorylation of these enzymes leads to enhanc... | SIGNOR-274033 |
P17612 | P35222 | 1 | phosphorylation | up-regulates activity | 0.478 | Although pka did not affect the formation of a complex between glycogen synthase kinase 3beta (gsk-3beta), beta-catenin, and axin, phosphorylation of beta-catenin by pka inhibited ubiquitination of beta-catenin in intact cells and in vitro. | SIGNOR-140902 |
P27986 | P68400 | 0 | phosphorylation | up-regulates activity | 0.246 | Protein kinase CK2 phosphorylates p85α on Ser608 when p85α is free but not when it is complexed with p110α. | SIGNOR-276005 |
P68400 | Q14940 | 1 | phosphorylation | down-regulates activity | 0.2 | CK2 phosphorylation of an acidic Ser/Thr di-isoleucine motif in the Na+/H+ exchanger NHE5 isoform promotes association with beta-arrestin2 and endocytosis | SIGNOR-276250 |
P54274 | P53350 | 0 | phosphorylation | up-regulates | 0.373 | Plk1 phosphorylation of trf1 is essential for its binding to telomeres | SIGNOR-179461 |
Q7L523 | Q8N8N0 | 0 | polyubiquitination | down-regulates activity | 0.74 | Here, we identified the lysosome-anchored E3 ubiquitin ligase RNF152 as an essential negative regulator of the mTORC1 pathway by targeting RagA for K63-linked ubiquitination. RNF152 interacts with and ubiquitinates RagA in an amino-acid-sensitive manner. The mutation of RagA ubiquitination sites abolishes this effect ... | SIGNOR-272222 |
O95721 | P51956 | 0 | phosphorylation | up-regulates activity | 0.2 | In the present study, we show that NEK3 (NIMA-never in mitosis gene A-related kinase 3)-mediated serine 105 (S105) phosphorylation of SNAP29 directs its membrane association, without which cells present defective focal adhesion formation, impaired Golgi structure and attenuated cellular recycling. Our results highlight... | SIGNOR-273708 |
P54253 | Q86Y13 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.483 | HOTAIR associates with E3 ubiquitin ligases bearing RNA-binding domains, Dzip3 and Mex3b, as well as with their respective ubiquitination substrates, Ataxin-1 and Snurportin-1. In this manner, HOTAIR facilitates the ubiquitination of Ataxin-1 by Dzip3 and Snurportin-1 by Mex3b in cells and in vitro, and accelerates the... | SIGNOR-272078 |
P29375 | Q99814 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.265 | To this end, we confirm that KDM3A, KDM4B, KDM4C, KDM5B, KDM5C, and KDM62 are direct targets of HIF-1a while extent the list of known targets to KDM2A, KDM2B, KDM4D, KDM5A, and KDM6A. The results demonstrated that majority of the KDMs were similarly induced (KDM2A, KDM2B, KDM3A, KDM4B, KDM4C, KDM4D, KDM5A, KDM5B, KDM5C... | SIGNOR-271580 |
Q8TF76 | Q96GD4 | 0 | phosphorylation | up-regulates activity | 0.2 | Phosphorylation by Aurora B is required for full Haspin activity toward H3T3 in mitosis | SIGNOR-262657 |
P17252 | O43526 | 1 | phosphorylation | up-regulates activity | 0.324 | Phosphorylation of KCNQ2 channels was increased by muscarinic stimulation; this was prevented either by coexpression with AKAP(DeltaA) or pretreatment with PKC inhibitors that compete with diacylglycerol. These inhibitors also reduced muscarinic inhibition of M-current. | These results suggest that Ser534 and 541 are k... | SIGNOR-249209 |
Q13422 | Q06187 | 0 | phosphorylation | up-regulates activity | 0.432 | We demonstrate that BTK phosphorylates Ikaros at unique phosphorylation sites S214 and S215 in the close vicinity of its zinc finger 4 (ZF4) within the DNA binding domain, thereby augmenting its nuclear localization and sequence-specific DNA binding activity. | SIGNOR-279442 |
P38936 | Q9H0Z9 | 0 | post transcriptional regulation | up-regulates quantity by stabilization | 0.318 | Here, we found that RNPC1, an RNA-binding protein and a target of the p53 family, is required for maintaining the stability of the basal and stress-induced p21 transcript. | SIGNOR-275391 |
Q969H0 | Q9UHV7 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.371 | The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator. We show that Fbw7, a tumor suppressor and ubiquitin ligase, binds to CDK8-Mediator and targets MED13/13L for degradation. MED13/13L physically link the CDK8 module to Mediator, and Fbw7 loss increases CDK8 modul... | SIGNOR-266690 |
P18031 | P11274 | 1 | dephosphorylation | down-regulates | 0.33 | These results illustrate selectivity in the effects of ptps in a cellular context and suggest that ptp1b may function as a specific, negative regulator of p210 bcr-abl signalling in vivo. | SIGNOR-56818 |
P62140 | O15169 | 1 | dephosphorylation | down-regulates activity | 0.2 | The data suggest that PP1 controls Wnt signaling through interaction with, and regulated dephosphorylation of, axin| Axin phosphorylation markedly enhances the binding of glycogen synthase kinase 3, leading to a more active beta-catenin destruction complex. Wnt-regulated changes in axin phosphorylation, mediated by PP1... | SIGNOR-248567 |
Q9BZS1 | P13501 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.434 | Given its role as a potent chemoattractant for T cells, CCL5 can be utilized to attract Tregs to malignant epithelial cells. Wang et al. demonstrated that Forkheadbox protein 3 (FOXP3), a key transcription factor for Tregs, was highly ex- pressed in pancreatic cancer cell lines, which, in turn, upregulated CCL5 express... | SIGNOR-277727 |
P62979 | Q93009 | 0 | cleavage | up-regulates quantity | 0.654 | Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, ... | SIGNOR-270824 |
P31749 | Q13418 | 0 | phosphorylation | up-regulates | 0.779 | Ilk can phosphorylate pkb-akt on serine-473, whereas kinase-deficient ilk severely inhibits endogenous phosphorylation of pkb-akt on serine-473, demonstrating that ilk is involved in agonist stimulated, pi(3)k-dependent, pkb-akt activation. | SIGNOR-252597 |
Q9UBF6 | P05412 | 1 | ubiquitination | down-regulates activity | 0.324 | SAG (Sensitive to Apoptosis Gene), also known as RBX2 (RING box protein 2), ROC2 (Regulator of Cullins 2), or RNF7 (RING Finger Protein 7), was originally cloned in our laboratory as a redox inducible antioxidant protein and later characterized as the second member of the RBX/ROC RING component of the SCF (SKP1-CUL-F-b... | SIGNOR-271452 |
Q8IY84 | P30291 | 1 | phosphorylation | down-regulates activity | 0.48 | Furthermore, purified bacterially produced Nim1 kinase directly phosphorylates and inactivates Wee1 in vitro.|Phosphorylation and inactivation of the mitotic inhibitor Wee1 by the nim1 and cdr1 kinase. | SIGNOR-279238 |
Q15796 | Q6ZNA4 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.685 | Arkadia represses the expression of myoblast differentiation markers through degradation of ski and the ski-bound smad complex in c2c12 myoblastsarkadia bound smad2/3 via ski to induce the ubiquitination of smad2/3. These results suggest that arkadia targets ski-bound, inactive phospho-smad2/3 to regulate positively my... | SIGNOR-236873 |
Q12857 | Q9Y6N7 | 1 | transcriptional regulation | up-regulates quantity | 0.2 | For example, within the NFI targetome, we identified 6 collagen genes, 13 genes encoding potassium channel or glutamate receptor subunits and a range of factors related to axon guidance (e.g. Slit1, Robo1, Epha4, Epha5, Epha8) | SIGNOR-268893 |
P46940 | P08581 | 0 | phosphorylation | up-regulates activity | 0.272 | IQGAP1 was phosphorylated exclusively on Tyr-1510 under conditions with enhanced MET or c-Src signaling, including in human lung cancer cell lines. This phosphorylation was significantly reduced by chemical inhibitors of MET or c-Src or by siRNA-mediated knockdown of MET. | SIGNOR-277532 |
Q16665 | Q9Y2N7 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.524 | None of the long HIF-3α variants was capable of efficient induction of an HRE reporter in overexpression experiments, but instead inhibited the transcriptional activation of the reporter by HIF-1 and HIF-2. | SIGNOR-261615 |
O15013 | P60953 | 1 | guanine nucleotide exchange factor | up-regulates activity | 0.499 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260537 |
P17612 | Q68EM7 | 1 | phosphorylation | down-regulates activity | 0.2 | Screening for potential mediators of this effect resulted in the identification of the Rac1-specific GTPase-activating protein ARHGAP17 and the guanine nucleotide exchange factor ARHGEF6 as new PKA and PKG substrates in platelets. We mapped the PKA/PKG phosphorylation sites to serine 702 on ARHGAP17 using Phos-tag gels... | SIGNOR-272155 |
P54578 | P61073 | 1 | deubiquitination | up-regulates quantity by stabilization | 0.448 | The physical interaction of CXCR4 and USP14 is paralleled by USP14-catalyzed deubiquitination of the receptor|We also observed that ubiquitination of CXCR4 facilitated receptor degradation, whereas overexpression of USP14 or RNAi-induced knockdown of USP14 blocked CXCL12-mediated CXCR4 degradation | SIGNOR-265057 |
P04637 | P09874 | 0 | relocalization | up-regulates activity | 0.559 | We identify the major poly(ADP-ribosyl)ated sites of p53 by PARP-1 and find that PARP-1-mediated poly(ADP-ribosyl)ation blocks the interaction between p53 and the nuclear export receptor Crm1, resulting in nuclear accumulation of p53. These findings molecularly link PARP-1 and p53 in the DNA-damage response, providing ... | SIGNOR-261321 |
Q9UGP5 | P78527 | 0 | phosphorylation | up-regulates activity | 0.467 | We show that Polλ is efficiently phosphorylated by DNA-PKcs in vitro and predominantly by ATM after DSB induction with ionizing radiation (IR) in vivo. We identify threonine 204 (T204) as a main target for ATM/DNA-PKcs phosphorylation on human Polλ, and establish that its phosphorylation may facilitate the repair of a... | SIGNOR-273835 |
P68400 | Q92688 | 1 | phosphorylation | up-regulates | 0.234 | Here, we are able to report that casein kinase 2 (ck2) phosphorylates april on residue threonine244 (thr(244)) and demonstrate that the ck2-specific inhibitor 4,5,6,7-tetrabromo-2-azabenzimidazole abolishes cd83 expression in activated jurkat t cells by interfering with the nucleocytoplasmic translocation of cd83 mrna | SIGNOR-183158 |
Q8WZ64 | P63000 | 1 | gtpase-activating protein | down-regulates activity | 0.463 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260454 |
Q12899 | Q96FI4 | 1 | ubiquitination | down-regulates quantity | 0.247 | Mule and TRIM26 ubiquitylate NEIL1 in vitro within C-terminal lysine residues.|Similar to these previous results, we again demonstrate that a knockdown of Mule or TRIM26 causes an elevation in the protein stability of NEIL1 in comparison to non-targeting siRNA, unirradiated control (Figure and ; compare lanes 1 and 2). | SIGNOR-278647 |
P13693 | P53350 | 0 | phosphorylation | down-regulates | 0.716 | Plk phosphorylates tctp on two serine residues. These results suggest that phosphorylation decreases the microtubule-stabilizing activity of tctp and promotes the increase in microtubule dynamics that occurs after metaphase | SIGNOR-91348 |
P11309 | Q96T88 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.2 | Here we report that UHRF1 is a novel substrate of PIM1 kinase, which could be phosphorylated at Ser311 and therefore promoted to degradation. | SIGNOR-277349 |
Q5S007 | Q9NPP4 | 1 | phosphorylation | up-regulates activity | 0.359 | LRRK2 phosphorylates NLRC4 at Ser533 upon inflammasome activation.|These data suggest that LRRK2 promotes NLRC4 inflammasome activation through its kinase activity. | SIGNOR-279338 |
O00399 | P06493 | 0 | phosphorylation | up-regulates activity | 0.307 | Here, we show that the p27/p25 heterodimer undergoes mitotic phosphorylation by cyclin‐dependent kinase 1 (Cdk1) at a single site, p27 Thr186, to generate an anchoring site for polo‐like kinase 1 (Plk1) at kinetochores. | SIGNOR-264777 |
P49840 | P20807 | 0 | cleavage | up-regulates activity | 0.2 | Thus, it has been shown that calpain cleaves the inhibitory domain of GSK3 generating two fragments of 40 and 30 kDa. This cleavage enhanced activity of the kinase | SIGNOR-251606 |
P27361 | O60674 | 1 | phosphorylation | down-regulates | 0.523 | We hypothesize that phosphorylation of ser523 in jak2 by erks 1 and/or 2 or other as-yet-unidentified kinases acts in a negative feedback manner | SIGNOR-146747 |
P05556 | P23470 | 0 | dephosphorylation | down-regulates activity | 0.265 | PTPRG activation by the P1-WD peptide affected the tyrosine phosphorylation of several signaling molecules. Data analysis identified 31 molecules whose phosphorylation was modified in a statistically significant manner (Table I). inhibition of ABL1, BMX, BTK, DAB1, ITGB1, JAK2, KDR, KIT, LIMK1, MET, PDGFRB, SHC1, and V... | SIGNOR-254706 |
P55895 | P42345 | 1 | relocalization | up-regulates | 0.267 | Rag gtpases, together with a multi-protein complex called ragulator, mediate amino acid-mediated mtor recruitment to the lysosome surface where mtor becomes activated. | SIGNOR-198245 |
P48050 | P17252 | 0 | phosphorylation | down-regulates activity | 0.2 | These results therefore indicate that Kir2.3 is directly modulated by PKC phosphorylation of its channel protein and threonine 53 is the PKC phosphorylation site in Kir2.3. | SIGNOR-275965 |
Q96J02 | P55957 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.352 | The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid | SIGNOR-271415 |
Q9Y4H2 | P46934 | 0 | ubiquitination | up-regulates activity | 0.374 | Nedd4 monoubiquitinates IRS-2, which promotes its association with Epsin1, a ubiquitin binding protein. | SIGNOR-278659 |
O94761 | P24941 | 0 | phosphorylation | up-regulates activity | 0.329 | During S/G2 phases, CDK1 and CDK2 (CDK1/2) phosphorylate RECQL4 on serines 89 and 251, enhancing MRE11/RECQL4 interaction and RECQL4 recruitment to DSBs. | SIGNOR-277374 |
P01241 | O60281 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | Rat Zn-15 is a transcription factor activating GH gene expression by synergistic interactions with Pit-1, named for 15 DNA-binding zinc fingers, including fingers IX, X, and XI that are responsible for GH promoter binding. | SIGNOR-268969 |
P06493 | Q07820 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.461 | Mcl-1 is phosphorylated at two sites in mitosis, ser64 and thr92. Phosphorylation of thr92 by cyclin-dependent kinase 1 (cdk1)-cyclin b1 initiates degradation of mcl-1 in cells arrested in mitosis by microtubule poisons. | SIGNOR-165867 |
P41250 | Q2TAL8 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | QRICH1 promotes the expression of translation-related genes. our combined ChIP-seq and RNA-seq analyses identified that QRICH1 and ATF4 were enriched at the promoters of these specific tRNA synthetases, and that ER stress positively regulated their transcription (Fig. 4I). Together, these findings suggest that QRICH1 a... | SIGNOR-269405 |
Q99717 | Q9UPW6 | 1 | transcriptional regulation | up-regulates quantity | 0.259 | Chromatin immunoprecipitation (ChIP) revealed a subset of the BIG (BMP4 induced genes) signature, including Satb2, Smad6, Hand1, Gadd45γ and Gata3, that was bound by Smad1/5 in the developing mandible, revealing direct Smad-mediated regulation | SIGNOR-268939 |
P04637 | P34947 | 0 | phosphorylation | down-regulates | 0.37 | Grk5, but not grk2 or grk6, phosphorylates p53 at thr-55, which promotes the degradation of p53, leading to inhibition of p53-dependent apoptotic response to genotoxic damage. | SIGNOR-163707 |
P06213 | Q07666 | 1 | phosphorylation | up-regulates activity | 0.363 | Thus, Tyr phosphorylation of Sam68 by IR could modulate its association with the splicing machinery in a similar way to that described for p59 fyn, and this way, it could influence splice site selection. | SIGNOR-278946 |
P07948 | P41240 | 0 | phosphorylation | down-regulates | 0.538 | Lyn tyr507 kinase, csk, is recruited by pag, which targets lipid rafts by palmitoylation.Thus, our data suggest that il-6 treatment induces the translocation of cd45 to lipid rafts sequentially, followed by the association of cd45 with lyn and pag;dephosphorylation of lyn tyr507 and pag tyr314;lyn activation;and csk re... | SIGNOR-132912 |
Q13976 | P11831 | 1 | phosphorylation | up-regulates | 0.275 | Myotonic dystrophy protein kinase (DMPK), a muscle- and neuron-restricted kinase, enhanced SRF-mediated promoter activity of the skeletal and cardiac alpha-actin genes in C2C12 myoblasts as well as in nonmyogenic cells. | Threonine 159 in the MADS box alphaI coil was a specific phosphorylation target in vitro as well a... | SIGNOR-188185 |
P51790 | Q9UQM7 | 0 | phosphorylation | up-regulates activity | 0.337 | Identification of an N-terminal amino acid of the CLC-3 chloride channel critical in phosphorylation-dependent activation of a CaMKII-activated chloride current|The N-terminus of CLC-3, which contains a CaMKII consensus sequence, was phosphorylated by CaMKII in vitro, and mutation of the serine at position 109 (S109A) ... | SIGNOR-275863 |
P13497 | P02452 | 1 | cleavage | up-regulates activity | 0.681 | BMP-1myc Expressed in COS-7 Cells Exhibits Procollagen C-proteinase Activity. Bone morphogenetic protein (BMP)-1, which belongs to the tolloid subgroup of astacin-like zinc metalloproteinases, cleaves the C-propeptides of procollagen at the physiologic site and is, therefore, a procollagen C-proteinase (PCP). Cleavage ... | SIGNOR-256342 |
Q99759 | P46734 | 1 | phosphorylation | up-regulates activity | 0.558 | These data indicate that mkk3 is preferentially activated by mekk3, whereas mkk4 is activated both by mekk2 and mekk3. | SIGNOR-48625 |
P84243 | Q96GD4 | 0 | phosphorylation | up-regulates activity | 0.2 | Phosphorylation at ser-11 (h3s10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. Phosphorylation at ser-11 (h3s10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. | SIGNOR-118890 |
Q14493 | O60814 | 1 | translation regulation | up-regulates quantity by expression | 0.2 | Synthesis of mature histone mRNA requires only a single processing reaction: an endonucleolytic cleavage between a conserved stem-loop and a purine-rich downstream element to form the 3' end. The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cy... | SIGNOR-265383 |
Q9H4B4 | P37840 | 1 | phosphorylation | down-regulates activity | 0.319 | Polo-like kinase (plk) family (plk1, plk2, and plk3) phosphorylate alpha-syn and beta-syn specifically at ser-129 and ser-118, respectively. Polo-like kinase 2 (plk2) phosphorylates alpha-synuclein at serine 129 in central nervous system. The membrane association of pd-linked mutant alpha -synuclein, but not wild-type ... | SIGNOR-189053 |
Q13526 | P53350 | 0 | phosphorylation | up-regulates | 0.424 | Here we demonstrate that ser-65 in pin1 is the major site for plk1-specific phosphorylation, and the polo-box domain of plk1 is required for this phosphorylation. Interestingly, the phosphorylation of pin1 by plk1 does not affect its isomerase activity but rather is linked to its protein stability. pin1 is ubiquitinat... | SIGNOR-139919 |
Q92945 | Q16549 | 0 | phosphorylation | down-regulates | 0.2 | Ksrp phosphorylated by p38 displays compromised binding to are-containing transcripts and fails to promote their rapid decay,although it retains the ability to interact with the mrna degradation machinery. | SIGNOR-143167 |
P05091 | Q13131 | 0 | phosphorylation | up-regulates activity | 0.2 | Further studies demonstrate that in the absence of LDLR, AMPK phosphorylates ALDH2 at threonine 356 and enables its nuclear translocation. Nuclear ALDH2 interacts with HDAC3 and represses transcription of a lysosomal proton pump protein ATP6V0E2, critical for maintaining lysosomal function, autophagy, and degradation o... | SIGNOR-271863 |
P17252 | Q92888 | 1 | phosphorylation | up-regulates activity | 0.439 | We showed that the first and second phase of RhoA activity are dependent on p63 and Ca2+/PKC, respectively, and further identified phosphorylation of serine 240 on p115 RhoGEF by PKC to be the mechanistic link between PKC and RhoA. | SIGNOR-277530 |
P14859 | Q13131 | 0 | phosphorylation | down-regulates | 0.2 | Mitosis-specific phosphorylation site in the homeodomain of oct-1 was phosphorylated in vitro by protein kinase a. Pka-mediated phosphorylation event was identified in the cns-specific pou domain protein brn-2/n-oct-3/pou3f2 (nieto et al. 2007). In this case, the modification, at a position homologous to oct1 s385, was... | SIGNOR-53254 |
Q86U44 | Q9BZX2 | 1 | post transcriptional regulation | up-regulates quantity by stabilization | 0.2 | Furthermore, the m6A modification regulated by METTL3 led to UCK2 increased messenger RNA (mRNA) stability in melanoma cancer. Functional and mechanistic experiments indicated that UCK2 enhanced the metastasis of melanoma cancer cells through the WNT/β-catenin pathway. | SIGNOR-275862 |
Q16236 | P48507 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.439 | NFE2L2 is stabilized and translocates to the nucleus, where it dimerizes with sMAF proteins. This complex binds to AREs to mediate the transcription of genes involved in iron metabolism, GSH metabolism, and ROS detoxification.Importantly, GCLC, GCLM, GSS, and GSR are transcriptional targets of NFE2L2. Their upregulatio... | SIGNOR-279869 |
O95999 | O14920 | 0 | phosphorylation | up-regulates activity | 0.772 | Here we show that the putative downstream kinase IKKbeta is required for initial CBM complex formation. Further, upon engagement of IKKbeta/Malt1/Bcl10 with Carma1, IKKbeta phosphorylates Bcl10 in the C terminus and thereby interferes with Bcl10/Malt1 association and Bcl10-mediated IKKgamma ubiquitination. Since only m... | SIGNOR-276292 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.