IdA string | IdB string | labels int64 | mechanism string | effect string | score float64 | sentence string | signor_id string |
|---|---|---|---|---|---|---|---|
P11831 | Q09013 | 0 | phosphorylation | up-regulates | 0.289 | Myotonic dystrophy protein kinase (DMPK), a muscle- and neuron-restricted kinase, enhanced SRF-mediated promoter activity of the skeletal and cardiac alpha-actin genes in C2C12 myoblasts as well as in nonmyogenic cells. | Threonine 159 in the MADS box alphaI coil was a specific phosphorylation target in vitro as well a... | SIGNOR-236982 |
P07288 | Q02447 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | We characterized four Sp1/Sp3 binding sites in the proximal promoter of the PSA gene. In a luciferase assay, these sites contributed to the basal promoter activity in prostate cancer cells. In an electrophoretic mobility shift assay and chromatin immunoprecipitation assay, we confirmed that Sp1 and Sp3 bind to these si... | SIGNOR-253665 |
Q9UBE8 | P40763 | 1 | phosphorylation | up-regulates | 0.347 | Phosphorylation of s727 induces pin1 binding which increases transcription. Pin1 binding increases stat3 interaction with p300 and dna. | SIGNOR-155828 |
P24723 | P29474 | 1 | phosphorylation | down-regulates activity | 0.2 | The phosphorylation of both S617 and S635 have also been shown to promote increased eNOS-derived NO release (Michell et al., 2002). The phosphorylaiton of S617 can be induced by PKA or Akt activity, and may serve to sensitize eNOS to calmodulin binding and modulate the phosphorylation of other eNOS sites | SIGNOR-251634 |
P28482 | Q8IW41 | 1 | phosphorylation | up-regulates | 0.48 | Activated following phosphorylation at thr-182 by p38-alpha/mapk14, p38-beta/mapk11, erk2/mapk1, erk3/mapk6, and erk4/mapk4. | SIGNOR-58127 |
P17612 | Q12809 | 1 | phosphorylation | up-regulates | 0.307 | Deletion of protein kinase a phosphorylation sites in the herg potassium channel inhibits activation shift by protein kinase afour consensus pka phosphorylation sites (s283a, s890a, t895a, s1137a) | SIGNOR-70726 |
P49840 | P23246 | 1 | phosphorylation | down-regulates | 0.2 | Psf is directly phosphorylated by gsk3, thus promoting interaction of psf with trap150, which prevents psf from binding cd45 pre-mrna. / threonine phosphorylation of psf by gsk3 primarily occurs on residue t687 | SIGNOR-168385 |
P37840 | P46934 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.372 | Here we show that the ubiquitin ligase Nedd4, which functions in the endosomal-lysosomal pathway, robustly ubiquitinates alpha-synuclein, unlike ligases previously implicated in its degradation. | SIGNOR-278611 |
Q15746 | P12931 | 0 | phosphorylation | up-regulates | 0.417 | Ec mlck-1 is phosphorylated by p60(src) on tyr(464) and tyr(471), resulting in a 2- to 3-fold increase in ec mlck-1 enzymatic activity. | SIGNOR-85009 |
O15530 | Q02750 | 1 | phosphorylation | up-regulates activity | 0.27 | In vitro kinase assay revealed that the direct targets of pdk1 in the mapk pathway were the upstream mapk kinases mek1 and mek2. The identified pdk1 phosphorylation sites in mek1 and mek2 are ser222 and ser226, respectively, and are known to be essential for full activation | SIGNOR-236633 |
P31749 | P20749 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.494 | Here we show that Akt, Erk2, and IKK1/2 phosphorylate Bcl3. Phosphorylation of Ser33 by Akt induces switching of K48 ubiquitination to K63 ubiquitination and thus promotes nuclear localization and stabilization of Bcl3. Phosphorylation by Erk2 and IKK1/2 of Ser114 and Ser446 converts Bcl3 into a transcriptional coregul... | SIGNOR-277358 |
P78317 | P41229 | 1 | sumoylation | up-regulates activity | 0.2 | Hendriks and coworkers showed that, in response to alkylation damage by methyl methanesulfonate (MMS), SUMOylated JARID1B (KDM5B) is ubiquitylated by the SUMOtargeted ubiquitin ligase RNF4 and degraded by the proteasome, whereas JARID1C (KDM5C) is SUMOylated and recruited to the chromatin to demethylate histone H3K4 (H... | SIGNOR-271576 |
P51452 | P40763 | 1 | dephosphorylation | down-regulates activity | 0.2 | DUSP3 interacted with the C-terminal domain of STAT3 and dephosphorylated p-Y705 of STAT3.|In summary, DUSP3 downregulated the transcriptional activity of STAT3 via dephosphorylation at Y705 and also suppressed the migratory activity of cancer cells. | SIGNOR-277070 |
P12931 | P49279 | 1 | phosphorylation | up-regulates activity | 0.281 | In this study, we provide evidence that SLC11A1 is phosphorylated by Src family kinases at tyrosine 15 present in a conserved tyrosine-based motif (YGSI) among all species. | SIGNOR-278500 |
Q8NEZ5 | O75164 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.339 | SCF(FBXO22) regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation | SIGNOR-273442 |
P19634 | Q15418 | 0 | phosphorylation | up-regulates | 0.452 | The results indicate that p90rsk phosphorylates serine 703 of nhe-1, and this phosphorylation is required for growth factor stimulation of na+/h+ exchange. | SIGNOR-69171 |
Q14493 | P20671 | 1 | translation regulation | up-regulates quantity by expression | 0.2 | Synthesis of mature histone mRNA requires only a single processing reaction: an endonucleolytic cleavage between a conserved stem-loop and a purine-rich downstream element to form the 3' end. The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cy... | SIGNOR-265399 |
P60484 | Q9H4B4 | 0 | phosphorylation | down-regulates activity | 0.335 | Plk3 phosphorylates pten on thr-366 and ser-370. Plk3-mediated phosphorylation facilitates pten stabilization, thereby negatively regulating the pi3k/pdk1/akt1 signaling axis | SIGNOR-168473 |
Q01970 | Q13976 | 0 | phosphorylation | down-regulates activity | 0.539 | PKG can directly phosphorylate PLC-beta2 and PLC-beta3 in vitro with purified proteins and in vivo with metabolic labeling. Phosphorylation of PLC-beta leads to the inhibition of G-protein-activated PLC-beta3 activity by 50-70% in COS-7 cell transfection assays. By using phosphopeptide mapping and site-directed mutagen... | SIGNOR-249077 |
P28482 | P78347 | 1 | phosphorylation | up-regulates | 0.364 | Tfii-i can be phosphorylated in vitro by erk and mutation of consensus map kinase substrate sites at serines 627 and 633 impairs the phosphorylation of tfii-i by erk and its activity on the c-fos promoter. These results suggest that erk regulates the activity of tfii-i by direct phosphorylation. | SIGNOR-74296 |
P31749 | O75030 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.44 | We found that AKT phosphorylates MITF at S510. Phosphorylated MITF S510 enhances its affinity to TP53 and promotes CDKN1A expression. Phosphorylation of MITF by AKT induces its degradation | SIGNOR-277281 |
P50876 | P78527 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.568 | We show that RNF144A induces ubiquitination of DNA-PKcs in vitro and in vivo and promotes its degradation. | SIGNOR-272213 |
O43768 | Q96GX5 | 0 | phosphorylation | up-regulates activity | 0.732 | We identified cyclic adenosine monophosphateregulated phosphoprotein 19 (Arpp19) and -Endosulfine as two substrates of Gwl that, when phosphorylated by this kinase, associate with and inhibit PP2A, thus promoting mitotic entry. | SIGNOR-243690 |
P15289 | P68871 | 1 | acetylation | up-regulates activity | 0.2 | ASA acetylates hemoglobin. Purified acetylated hemoglobin had a slightly increased oxygen affinity and decreased heme-heme interaction. | SIGNOR-251772 |
O00501 | P11308 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.224 | ETS-related gene (ERG) controls endothelial cell permeability via transcriptional regulation of the claudin 5 (CLDN5) gene. | SIGNOR-261596 |
O96017 | Q15717 | 1 | phosphorylation | down-regulates activity | 0.55 | Given the fact that Chk2 phosphorylates HuR at residues S88, S100 and T118 and that each individual phosphorylation site by Chk2 plays a distinct role in regulating HuR- binding to different target mRNAs (22,42), we further tested HuR mutants with alanine substitutions at each of the Chk2 phosphorylation sites. | SIGNOR-278163 |
P60510 | Q9GZM8 | 1 | dephosphorylation | down-regulates activity | 0.395 | Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation|PP4c selectively dephosphorylates NDEL1 at Cdk1 sites. We also demonstrate that PP4c negatively regulates Cdk1 activity at the centrosome.|We next examined the ability of PP4c to dephosphorylate a Cd... | SIGNOR-248550 |
O14757 | O15151 | 1 | phosphorylation | down-regulates activity | 0.52 | MDMX is a direct substrate for Chk1 and Chk2 in vitro. Phosphorylation of MDMX leads to increased binding to MDM2 and more efficient ubiquitination, providing an explanation for the enhanced degradation of MDMX after DNA damage. | Western blot showed that Chk1 modified S342 and S367, but with strong preference for S342... | SIGNOR-250770 |
Q9Y297 | P08151 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.664 | Here we show that Gli is rapidly destroyed by the proteasome and that mouse basal cell carcinoma induction correlates with Gli protein accumulation. We identify two independent destruction signals in Gli1, D(N) and D(C), and show that removal of these signals stabilizes Gli1 protein and rapidly accelerates tumor format... | SIGNOR-235631 |
Q9H2G2 | Q99683 | 1 | phosphorylation | up-regulates | 0.253 | Induction of apoptosis by the ste20-like kinase slk, a germinal center kinase that activates apoptosis signal-regulating kinase and p38 | SIGNOR-142665 |
P50613 | Q01094 | 1 | phosphorylation | down-regulates | 0.493 | These results suggest that tfiih-mediated phosphorylation of e2f-1 plays a role in triggering e2f-1 degradation during s phase. here we show that the e2f-1 activation domain interacts with a kinase activity which phosphorylates two sites, ser403 and thr433, within the activation domain. | SIGNOR-69776 |
Q8IYK4 | P02452 | 1 | glycosylation | up-regulates activity | 0.442 | Recombinant GLT25D1 and GLT25D2 enzymes showed a strong galactosyltransferase activity toward various types of collagen and toward the serum mannose-binding lectin MBL, which contains a collagen domain. Amino acid analysis of the products of GLT25D1 and GLT25D2 reactions confirmed the transfer of galactose to hydroxyly... | SIGNOR-261156 |
P09601 | P69905 | 1 | null | down-regulates activity | 0.253 | Heme oxygenase (HO), by catabolizing heme to bile pigments, down-regulates cellular hemoprotein, hemoglobin, and heme | SIGNOR-251813 |
P21860 | P00533 | 0 | phosphorylation | up-regulates | 0.67 | The erbb3 protein which possesses little or no intrinsic protein tyrosine kinase activiity is phosphorylated by the activated egf receptor protein tyrosine kinase on tyrosine residues within the yxxm sequence motif. These phosphorylated tyrosine residues interact with the p85 regulatory subunit of pi 3-kinase, which co... | SIGNOR-34748 |
O75030 | Q9HAZ1 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.2 | Mechanistically, wild type CLK4 (WT-CLK4) but not kinase-dead CLK4-K189R mutant phosphorylated MITF at Y360. This modification promoted its interaction with E3 ligase COP1 and its K63-linked ubiquitination at K308/K372, leading to sequestosome 1 recognition and autophagic degradation. | SIGNOR-274116 |
P06493 | Q13541 | 1 | phosphorylation | down-regulates activity | 0.397 | Phosphorylation of 4e-bp1 is critical in causing its dissociation from eif-4e, leaving 4e available to form translationally active eif-4f complexes, switching on mrna translation. We show that the cyclin-dependent kinase, cdc2, phosphorylates 4e-bp1 at thr-70 and that phosphorylation of this site is permissive for ser-... | SIGNOR-110416 |
Q13188 | P40763 | 1 | phosphorylation | down-regulates activity | 0.2 | Hippo pathway component MST2 kinase phosphorylates STAT3 at T622, which is located in the SH2 domain of STAT3. This phosphorylation blocks the SH2 domain in one STAT3 molecule to bind with the phosphorylated Y705 site in another STAT3 molecule, which further counteracts IL6-induced STAT3 dimerization and activation. | SIGNOR-277599 |
Q2Q1W2 | P04637 | 1 | ubiquitination | down-regulates quantity | 0.272 | LIN41 promotes ubiquitination of p53 in response to RA.|Loss of LIN41 elevates p53 steady-state levels and reduces p53 ubiquitination. | SIGNOR-278679 |
P15407 | P15408 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.403 | Members of the AP1 family distinctly regulated the fra-1 promoter. In particular, coexpression of c-Jun, Jun-D, and Fra-2 up-regulated fra-1 transcription. | SIGNOR-261602 |
P12931 | Q9BXK1 | 1 | phosphorylation | up-regulates activity | 0.245 | We further confirmed that the Tyr-10 residue of KLF16 is phosphorylated in uterine cells (Fig. 7c). Additional experiments using both pharmacological and dominant negative inhibitors of Src further supported a role for this tyrosine kinase in modulating the activity of KLF16 (Fig. 7, d and f). | SIGNOR-276398 |
P00519 | O14746 | 1 | phosphorylation | down-regulates activity | 0.66 | These findings indicate that phosphorylation of hTERT by c-Abl is associated with inhibition of telomerase activity.|We also found that c-Abl phosphorylates hTERT and inhibits hTERT activity. | SIGNOR-279354 |
P17987 | P36508 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.347 | The transcription from the minimalCcta promoter was up-regulated 3-fold by ZNF143 and 6-fold by ZNF76 when full-length proteins were co-expressed, indicating that both ZNF143 and ZNF76 can enhance Ccta transcription. | SIGNOR-266221 |
Q71U36 | Q8NG68 | 0 | tyrosination | down-regulates | 0.533 | Tubulin tyrosine ligase (ttl) adds a c-terminal tyr to __tubulin as part of a tyrosination/detyrosination cycle present in most eukaryotic cells. / ttl inhibits spontaneous tubulin polymerization | SIGNOR-176912 |
Q15652 | P84243 | 1 | demethylation | down-regulates activity | 0.2 | We now determine that JMJD1C is recruited by USF-1 to various lipogenic genes for H3K9 demethylation to enhance chromatin accessibility in the fed state. | SIGNOR-265169 |
Q8N752 | O75581 | 1 | phosphorylation | up-regulates | 0.254 | Ck1 also phosphorylates lrp6 at the second ser residue in the pppspxs motif ck1_ in the lrp5/e-cadherin/p120-catenin complex temporally coincides with p120-catenin phosphorylation in ser268. moreover, and considering the close similarity between the catalytic domains of ck1_ and ck1_, it is possible that ck1_ is inde... | SIGNOR-173853 |
P42229 | P24394 | 0 | null | up-regulates | 0.556 | Several cytokine receptors share subchains and targets. For example, the common gamma chain (CGC) is shared by IL2, IL4, IL7, IL9 and IL15 receptors that lead to the activation of STAT5 | SIGNOR-254298 |
Q13873 | Q9HAU4 | 0 | ubiquitination | down-regulates | 0.503 | Smurf1 and smurf2 are e3 ubiquitin ligases known to suppress tgf-beta signaling through degra-dation of smads and receptors for tgf-beta and bmps. | SIGNOR-193119 |
P55017 | O95747 | 0 | phosphorylation | up-regulates | 0.388 | We demonstrate that the spak and osr1 kinases that are activated by wnk1 phosphorylate human ncc at three conserved residues (thr46, thr55 and thr60) / our results also indicate that phosphorylation of thr60 plays the most crucial role in triggering the activation of ncc in hek293 cells and its mutation also inhibits p... | SIGNOR-160833 |
Q12913 | P08581 | 1 | dephosphorylation | down-regulates activity | 0.608 | When co-expressed in 293 cells, the full-length substrate-trapping mutant form of DEP-1 formed a stable complex with the chimeric receptor colony stimulating factor 1 (CSF)-Met and wild type DEP-1 dephosphorylated CSF-Met. Furthermore, we observed that DEP-1 preferentially dephosphorylated a Gab1 binding site (Tyr(1349... | SIGNOR-248702 |
Q13224 | O15409 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.318 | By interacting with CASK, TBR1 regulates several ASD candidate genes, such as GRIN2B, AUTS2 and RELN—all of which are recurrently mutated in ASD. In areas of the brain with overlapping expression patterns, such as in glutamatergic layer 6 neurons, the TBR1–FOXP2 interaction may result in co-ordinated regulation of comm... | SIGNOR-266834 |
P04637 | P48730 | 0 | phosphorylation | up-regulates | 0.578 | Here we show that the direct association between a p53 n-terminal peptide and mdm2 is disrupted by phosphorylation of the peptide on thr(18) but not by phosphorylation at other n-terminal sites, including ser(15) and ser(37). Thr(18) was phosphorylated in vitro by casein kinase (ck1). | SIGNOR-75889 |
P17252 | P17844 | 1 | phosphorylation | down-regulates activity | 0.335 | We report that p68 is phosphorylated by protein kinase C in vitro and binds calmodulin in a Ca(2+)-dependent manner. Both phosphorylation and calmodulin binding inhibited p68 ATPase activity | In addition, a 20-amino acid peptide corresponding to residues 549-568 of p68 was phosphorylated in a Ca- and phospholipid-dep... | SIGNOR-248896 |
Q06124 | P32927 | 1 | dephosphorylation | up-regulates | 0.511 | Shp2 is thought to act as a positive mediator of growth factor signals.. Hp2 could act as an adaptor between the activated c and grb2, thus leading to activation of the ras/mitogen-activated protein kinase pathway, known to be activated by il-3 | SIGNOR-48557 |
O60313 | Q96TA2 | 0 | cleavage | up-regulates activity | 0.455 | YME1L cleaves OPA1 at S2 and S3 site to transform into L-OPA1 to induce fusion when cells are faced with increased oxidative phosphorylation, whereas OMA1 cleaves OPA1 at an S1 site to transform into S-OPA1, resulting in the fragmented response to cellular stress, mitochondrial dysfunction, or deletion of YME1L | SIGNOR-274140 |
P17612 | Q00613 | 1 | phosphorylation | up-regulates | 0.314 | Protein kinase a binds and activates heat shock factor 1hsf1 binds avidly to the catalytic subunit of pka, (pkac_) and becomes phosphorylated on a novel serine phosphorylation site within its central regulatory domain (serine 320 or s320), both in vitro and in vivo. Intracellular pkac_ levels and phosphorylation of hsf... | SIGNOR-169853 |
P04798 | P27540 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.646 | Kaempferol proved to be capable of inhibiting binding of agonist and agonist-induced formation of the AHR/ARNT DNA-binding complex and upregulation of the AHR target gene, CYP1A1. | SIGNOR-259910 |
O60928 | P17612 | 0 | phosphorylation | up-regulates | 0.2 | Pka activation induced an increase of kir7.1 currents. This effect was absent in mutant kir7.1 channels lacking pka consensus site (287)s | SIGNOR-181859 |
P62834 | Q9Y4G8 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.789 | Our data are consistent with a pathway involving the cAMP-mediated activation of Rapgef2, which then stimulates Rap1, leading to increases in B-Raf, MEK, and ERK activity.Increased intracellular concentrations of cAMP enhanced the Rapgef2-dependent activation of Rap1, which in turn associated with B-Raf to enable the a... | SIGNOR-276609 |
Q9NX47 | Q07820 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.2 | MARCH5 promotes ubiquitination of MCL1 and NOXA.|Together, this suggests that degradation of MCL1 by MARCH5 depends on binding to NOXA, but degradation of NOXA may be promoted by additional E3-ligases if MCL1 levels become limited, or can simply no longer be degraded. | SIGNOR-278700 |
Q12778 | Q13237 | 0 | phosphorylation | up-regulates activity | 0.356 | Biochemical assays using mammalian cGKII and FoxO1 reveal that cGKII enhances the transcriptional activity of FoxO1 through phosphorylation of the FoxO1 S319 site in the same manner as LRRK2. | SIGNOR-279564 |
Q9NRW1 | O43896 | 0 | relocalization | up-regulates quantity | 0.2 | Here, we identify Bicaudal-D-related protein 1 (BICDR-1) as an effector of the small GTPase Rab6 and key component of the molecular machinery that controls secretory vesicle transport in developing neurons. BICDR-1 interacts with kinesin motor Kif1C, the dynein/dynactin retrograde motor complex, regulates the pericentr... | SIGNOR-266878 |
Q96RR4 | P53355 | 0 | phosphorylation | down-regulates | 0.283 | Dapk phosphorylates camkk. S511 was identified as the phosphorylation site . a potential mechanism of action was identified on the basis of the location of s511 near the cam recognition domain of camkk and demonstrated by attenuation of cam-stimulated camkk autophosphorylation after dapk phosphorylation. | SIGNOR-126241 |
Q14195 | Q92630 | 0 | phosphorylation | up-regulates activity | 0.364 | Together, these results suggest that crmp4 is able to increase neurite formation and elongation in neurons, although not as potently as crmp2, and that this process is regulated by ser522/ser518/thr514/thr509 phosphorylation in both cases. We demonstrate that cdk5 primes crmp2 and crmp4 for subsequent phosphorylation b... | SIGNOR-145987 |
O60502 | P11413 | 1 | deglycosylation | down-regulates activity | 0.2 | O-GlcNAcylation of G6PD promotes the pentose phosphate pathway and tumor growth|O-GlcNAcylation of G6PD activates enzyme activity|G6PD is dynamically modified by O-GlcNAc at serine 84|In cells, a single set of antagonistic enzymes-O-GlcNAc transferase (OGT) and O-GlcNAc hydrolase are responsible for the addition and re... | SIGNOR-267605 |
P68431 | Q9NRC8 | 0 | deacetylation | up-regulates activity | 0.2 | SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation.|Genome-wide binding studies reveal that SIRT7 binds to promoters of a specific set of gene targets, where it deacetylates H3K18Ac and promotes transcriptional repression. | SIGNOR-275874 |
P37173 | P12931 | 0 | phosphorylation | up-regulates | 0.281 | Tbetarii can also be phosphorylated by src, a non-rtk, on y284, which can serve as a docking site for the recruitment of grb2 and shc, thereby bridging tbetarii to mapk activation. | SIGNOR-182963 |
P45985 | Q13233 | 0 | phosphorylation | up-regulates activity | 0.729 | The gck-ctd-mekk1 interaction is sufficiently stable to support mekk1 s phosphorylation of its substrate, sek1 | SIGNOR-236380 |
Q14469 | Q9UM73 | 0 | phosphorylation | up-regulates activity | 0.266 | NPM-ALK also directly phosphorylates HES1 protein. | SIGNOR-280181 |
P08123 | Q8NBJ5 | 0 | glycosylation | up-regulates activity | 0.429 | Recombinant GLT25D1 and GLT25D2 enzymes showed a strong galactosyltransferase activity toward various types of collagen and toward the serum mannose-binding lectin MBL, which contains a collagen domain. Amino acid analysis of the products of GLT25D1 and GLT25D2 reactions confirmed the transfer of galactose to hydroxyly... | SIGNOR-261153 |
O95600 | P68871 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.2 | These results establish KLF8 as a CACCC-box binding protein that associates with CtBP and represses transcription. | SIGNOR-266052 |
O00327 | P11387 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.342 | We examined the mechanism of topoisomerase I (Top1) to understand the role of the unique chromatin structure in Bmal1 gene regulation. Promoter assays showed that the Top1-binding site is required for transcriptional suppression and that it functions cooperatively with the distal RORE, supporting that Bmal1 transcript... | SIGNOR-277354 |
Q16539 | Q9UK80 | 1 | phosphorylation | up-regulates activity | 0.253 | In this study, we found that USP21 is an important deubiquitinating enzyme for STING and that it negatively regulates the DNA virus-induced production of type I interferons by hydrolyzing K27/63-linked polyubiquitin chain on STING. HSV-1 infection recruited USP21 to STING at late stage by p38-mediated phosphorylation o... | SIGNOR-273670 |
Q16566 | P16949 | 1 | phosphorylation | down-regulates | 0.49 | Serine 16 of oncoprotein 18 is a major cytosolic target for the ca2+/calmodulin-dependent kinase-gr. | SIGNOR-34743 |
O75385 | Q8IVP5 | 1 | phosphorylation | up-regulates activity | 0.595 | Here, we show that ULK1 is upregulated and translocates to fragmented mitochondria upon mitophagy induction by either hypoxia or mitochondrial uncouplers. At mitochondria, ULK1 interacts with FUNDC1, phosphorylating it at serine 17, which enhances FUNDC1 binding to LC3. | SIGNOR-273606 |
P16066 | P52961 | 1 | phosphorylation | down-regulates activity | 0.2 | Art1 is a substrate for the kinase Npr1, which phosphorylates Art1 and, thereby, causes its inactivation by limiting its plasma membrane association. | SIGNOR-279239 |
Q15910 | O60674 | 0 | phosphorylation | down-regulates | 0.534 | Oncogenic y641 mutations in ezh2 prevent jak2/beta-trcp-mediated degradationbeta-trcp ubiquitinates ezh2 and jak2-mediated phosphorylation on y641 directs beta-trcp-mediated ezh2 degradation. | SIGNOR-202711 |
Q99708 | Q13535 | 0 | phosphorylation | up-regulates | 0.615 | Characterization of this site using phospho-specific antibodies and mutational analysis reveals that it is phosphorylated by atr and is required for binding of ctip to chromatin and subsequent processive resection. | SIGNOR-200245 |
P26358 | Q13131 | 0 | phosphorylation | down-regulates activity | 0.2 | Together, these results indicate that AMPK phosphorylated DNMT1-Ser730, RBBP7-Ser314, and HAT1-Ser190|AMPK decreased DNMT1 activity | SIGNOR-264783 |
P53350 | P47736 | 1 | phosphorylation | down-regulates | 0.452 | Plk1 phosphorylates ser525 in conserved 524dsghvs529 degron of rap1gap and promotes its interaction with _-trcp. Together, these results further support a model in which plk1, but not cdk1 or gsk-3_-mediated phosphorylation of rap1gap is a prerequisite for mitotic degradation. | SIGNOR-205577 |
Q07817 | P45983 | 0 | phosphorylation | down-regulates | 0.775 | By site-directed mutagenesis studies, we have identified that serine 62 is the necessary site for taxol- or 2-me-induced bcl-xl phosphorylation in prostate cancer cells. Further studies with the inhibitor of jun kinase (jnk) and phosphorylation mutant of bcl-xl reveal the augmentative role of jnk-mediated bcl-xl phosph... | SIGNOR-99219 |
Q6PIY7 | P22694 | 0 | phosphorylation | down-regulates activity | 0.2 | We found that Gld2 activity is regulated by site-specific phosphorylation in its disordered N-terminal domain. We identified two phosphorylation sites (S62, S110) where phosphomimetic substitutions increased Gld2 activity and one site (S116) that markedly reduced activity. Using mass spectrometry, we confirmed that HEK... | SIGNOR-259403 |
Q05086 | P17612 | 0 | phosphorylation | down-regulates activity | 0.328 | These data suggest that PKA phosphorylation at T485 inhibits UBE3A ubiquitin ligase activity in cells. | SIGNOR-236899 |
P02545 | Q9UH99 | 1 | relocalization | up-regulates activity | 0.622 | In the case of Sun2, there is some evidence that A-type lamins might contribute to Sun2 localization in the INM. We report that an interaction between subunits of the HOPS complex and the ERM (ezrin, radixin, moesin) proteins is required for the delivery of EGF receptor (EGFR) to lysosomes. Inhibiting either ERM protei... | SIGNOR-261310 |
Q15831 | Q96EB6 | 1 | phosphorylation | up-regulates activity | 0.573 | Resveratrol promotes the binding between LKB1 and Sirt1, which we first reported, and this binding leads to LKB1-mediated phosphorylation of Sirt1 at three different serine residues in the C terminus of Sirt1. Mechanistically, LKB1-mediated phosphorylation increases intramolecular interactions in Sirt1, such as the bi... | SIGNOR-277323 |
O94988 | P63000 | 1 | gtpase-activating protein | down-regulates activity | 0.435 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260502 |
Q9Y6E0 | Q9Y2H1 | 1 | phosphorylation | up-regulates | 0.441 | Ndr1/ndr2 protein kinase is activated by phosphorylation on the activation loop phosphorylation site ser281/ser282 and the hydrophobic motif phosphorylation site thr444/thr442. Autophosphorylation of ndr is responsible for phosphorylation on ser281/ser282, whereas thr444/thr442 is targeted by an upstream kinase. Here w... | SIGNOR-142510 |
Q96PU5 | Q15796 | 1 | ubiquitination | down-regulates activity | 0.781 | Through its ww domain, nedd4l specifically recognizes a tgf-beta-induced phosphothr-protyr motif in the linker region, resulting in smad2/3 polyubiquitination and degradation | SIGNOR-217622 |
Q00987 | Q13547 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.468 | MDM2 induces ubiquitination of HDAC1 in VSMCs.|Under calcification inducing conditions, proteasomal degradation of HDAC1 precedes VC and it is mediated by MDM2 E3 ubiquitin ligase that initiates HDAC1 K74 ubiquitination. | SIGNOR-278761 |
P00533 | P17252 | 0 | phosphorylation | down-regulates activity | 0.609 | Biochemical and morphological analyses indicate that threonine-phosphorylated EGFR molecules undergo normal internalization, but instead of sorting to lysosomal degradation, they recycle back to the cell surfaceThe inhibitory effects of pkc are mediated by a single threonine residue (threonine 654) of egfr | SIGNOR-77421 |
P03372 | O00170 | 0 | transcriptional regulation | down-regulates activity | 0.291 | The immunophilin-like protein XAP2 is a negative regulator of estrogen signaling through interaction with estrogen receptor α. | SIGNOR-253644 |
P42575 | P62136 | 0 | dephosphorylation | up-regulates activity | 0.2 | nutrient-replete oocytes inhibit C2 via S135 phosphorylation catalyzed by calcium/calmodulin-dependent protein kinase II. We now show that C2 phosphorylated at S135 binds 14-3-3zeta, thus preventing C2 dephosphorylation. Moreover, we determined that S135 dephosphorylation is catalyzed by protein phosphatase-1 (PP1), wh... | SIGNOR-248564 |
P51812 | P18848 | 1 | phosphorylation | up-regulates | 0.633 | Here, we show that rsk2 is required for osteoblast differentiation and function. We identify the transcription factor atf4 as a critical substrate of rsk2 that is required for the timely onset of osteoblast differentiation, for terminal differentiation of osteoblasts, and for osteoblast-specific gene expression | SIGNOR-124436 |
A6ND36 | Q15139 | 0 | phosphorylation | up-regulates activity | 0.2 | Taken together, these data demonstrate that FAM83G S356 phosphorylation modulates HSP27 phosphorylation and apoptosis regulation and that HSP27 is a counterpart of FAM83G.|an active form of PKD1/PKCm could phosphorylate the FAM83G peptide, including the S356 portion.|We also demonstrated that the phosphorylation of the... | SIGNOR-264764 |
P31751 | O00327 | 1 | phosphorylation | down-regulates activity | 0.358 | Consistent with mass spectrometry results, constitutive active Akt2 (Akt2-CA) induced wild-type (WT) Bmal1 protein phosphorylation, which was abolished by a serine to alanine mutation at Ser42 residue (S42A) but not a S422A/S513A double mutation, as shown by immunoblot assay with phospho-Akt substrate antiserum ( xref ... | SIGNOR-280177 |
Q12857 | P41221 | 1 | transcriptional regulation | down-regulates quantity | 0.2 | By integrating transcriptomic profiling (RNA-seq) of Nfia- and Nfix-deficient GNPs with epigenomic profiling (ChIP-seq against NFIA, NFIB and NFIX, and DNase I hypersensitivity assays), we reveal that these transcription factors share a large set of potential transcriptional targets, suggestive of complementary roles f... | SIGNOR-268877 |
P28482 | Q15746 | 1 | phosphorylation | up-regulates activity | 0.478 | Inhibition of ERK2 impaired phosphorylation of MLCK and insulin stimulated glucose uptake.|These findings suggest that ERK2 activates MLCK which then mediates the phosphorylation of RLC of MyoIIA. | SIGNOR-279226 |
Q13469 | Q00987 | 0 | ubiquitination | down-regulates quantity | 0.306 | MDM2 negatively regulates NFATc2 and T cell activation.|The E3 ubiquitin ligase MDM2 is known to induce NFATc2 ubiquitination in a breast cancer cell line 24. | SIGNOR-278657 |
O75676 | Q16539 | 0 | phosphorylation | up-regulates | 0.604 | Rskb, a 90-kda ribosomal s6 protein kinase family (rsk) member with two complete catalytic domains connected by a linker, is activated through p38- and erk-mitogen-activated protein kinases. unlike other rsks, the activation loop phosphorylation sites of both catalytic domains of rskb, ser(196) and thr(568), were requ... | SIGNOR-77212 |
P78527 | P15927 | 1 | phosphorylation | down-regulates activity | 0.579 | We showed previously that UV irradiation increases phosphorylation of the p34 subunit of human replication protein A (RPA) and that this hyperphosphorylation correlated with loss of activity of the DNA replication complex. | we detected phosphorylation of the RPA complex by DNA-PK on RPA-p34 sites Ser-23, Ser-29, and ... | SIGNOR-248981 |
Q01538 | P46937 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.2 | Myt1 and Myt1l transcription factors limit proliferation in GBM cells by repressing YAP1 expression. Examination of the gene expression changes in cells expressing Myt1 or Myt1l suggests that both repress expression of the YAP1 transcriptional coactivator, which functions primarily in the Hippo signaling pathway. Expre... | SIGNOR-266777 |
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